Digital Commons Network^™

Increase In Superficial Dose In Whole-Breast Irradiation With Halcyon Straight-Through Linac Compared With Traditional C-Arm Linac With Flattening Filter: In Vivo Dosimetry And Planning Study, Fionnbarr O'Grady, Andrew R. Barsky, Shibu Anamalayil, Gary M. Freedman, Christopher Kennedy, Bin Cai, Eric Laugeman, Lei Dong, Geoffrey D. Hugo, James M. Metz, Sasa Mutic, Neil K. Taunk, Taoran Li

Open Access Publications

No abstract provided.

Evaluation Of A New Secondary Dose Calculation Software For Gamma Knife Radiosurgery, Michael T Prusator, Tianyu Zhao, James A Kavanaugh, Lakshmi Santanam, Joe Dise, S Murty Goddu, Timothy J Mitchell, Jacqueline E Zoberi, Taeho Kim, Sasa Mutic, Nels C Knutson

Open Access Publications

Current available secondary dose calculation software for Gamma Knife radiosurgery falls short in situations where the target is shallow in depth or when the patient is positioned with a gamma angle other than 90°. In this work, we evaluate a new secondary calculation software which utilizes an innovative method to handle nonstandard gamma angles and image thresholding to render the skull for dose calculation. 800 treatment targets previously treated with our GammaKnife Icon system were imported from our treatment planning system (GammaPlan 11.0.3) and a secondary dose calculation was conducted. The agreement between the new calculations and the TPS were …

Protective And Pathogenic Effects Of Interferon Signaling During Pregnancy, Rebecca L. Casazza, Helen M. Lazear, Jonathan J. Miner

Open Access Publications

No abstract provided.

Uterine Natural Killer Cell Heterogeneity: Lessons From Mouse Models, Dorothy K Sojka

Open Access Publications

Natural killer (NK) cells are the most abundant lymphocytes at the maternal-fetal interface. Epidemiological data implicate NK cells in human pregnancy outcomes. Discoveries using mouse NK cells have guided subsequent advances in human NK cell biology. However, it remains challenging to identify mouse and human uterine NK (uNK) cell function(s) because of the dynamic changes in the systemic-endocrinological and local uterine structural microenvironments during pregnancy. This review discusses functional similarities and differences between mouse and human NK cells at the maternal-fetal interface.

Trends In Postrelapse Survival In Classic Hodgkin Lymphoma Patients After Experiencing Therapy Failure Following Auto-Hct, Talha Badar, Narendranath Epperla, Aniko Szabo, Steven Borson, John Vaughn, Gemlyn George, Neeraj Saini, Abdul Rashid Shah, Romil D. Patel, Sairah Ahmed, Nirav N. Shah, Amanda F. Cashen, Mehdi Hamadani, Timothy S. Fenske

Open Access Publications

No abstract provided.

Predictive Value Of Midtrimester Universal Cervical Length Screening Based On Parity, Joshua I. Rosenbloom, Nandini Raghuraman, Lorene A. Temming, Molly J. Stout, Methodius G. Tuuli, Jeffery M. Dicke, George A. Macones, Alison G. Cahill

Open Access Publications

OBJECTIVES: To evaluate the effect of parity on performance characteristics of midtrimester cervical length (CL) in predicting spontaneous preterm birth (sPTB) before 37 weeks.

METHODS: This was a retrospective cohort study of 13,508 women with no history of sPTB undergoing universal transvaginal CL screening at 17 to 23 weeks' gestation from 2011 to 2016. Patients who declined screening or with unknown delivery outcomes were excluded. Areas under the receiver operator characteristic curves were used to assess and compare the predictive ability of CL screening for sPTB. The sensitivity, specificity, and positive and negative predictive values were estimated for specific CL …

Melanin Deposition In Two Cryptococcus Species Depends On Cell-Wall Composition And Flexibility, Christine Chrissian, Emma Comacho, Man Shun Fu, Rafael Prados-Rosales, Subhasish Chatterjee, Radames J.B. Cordero, Jennifer K. Lodge, Arturo Casadevall, Ruth E. Stark

Open Access Publications

No abstract provided.

Critical Response To Ab Interno Versus Ab Externo Surgical Approach On Outflow Resistance Of A Subconjunctival Drainage Device, Arsham Sheybani, Davinder S. Grover, Ronald L. Fellman

Open Access Publications

No abstract provided.

Use Of Neuroimaging To Inform Optimal Neurocognitive Criteria For Detecting Hiv-Associated Brain Abnormalities, Laura M Campbell, David B Clifford, Et Al, Charter Group

Open Access Publications

OBJECTIVE: Frascati international research criteria for HIV-associated neurocognitive disorders (HAND) are controversial; some investigators have argued that Frascati criteria are too liberal, resulting in a high false positive rate. Meyer et al. recommended more conservative revisions to HAND criteria, including exploring other commonly used methodologies for neurocognitive impairment (NCI) in HIV including the global deficit score (GDS). This study compares NCI classifications by Frascati, Meyer, and GDS methods, in relation to neuroimaging markers of brain integrity in HIV.

METHOD: Two hundred forty-one people living with HIV (PLWH) without current substance use disorder or severe (confounding) comorbid conditions underwent comprehensive neurocognitive …

A Framework For Applying Natural Language Processing In Digital Health Interventions, Burkhardt Funk, Shiri Sadeh-Sharvit, Ellen E Fitzsimmons-Craft, Mickey Todd Trockel, Grace E Monterubio, Neha J Goel, Katherine N Balantekin, Dawn M Eichen, Rachael E Flatt, Marie-Laure Firebaugh, Corinna Jacobi, Andrea K Graham, Mark Hoogendoorn, Denise E Wilfley, C Barr Taylor

Open Access Publications

BACKGROUND: Digital health interventions (DHIs) are poised to reduce target symptoms in a scalable, affordable, and empirically supported way. DHIs that involve coaching or clinical support often collect text data from 2 sources: (1) open correspondence between users and the trained practitioners supporting them through a messaging system and (2) text data recorded during the intervention by users, such as diary entries. Natural language processing (NLP) offers methods for analyzing text, augmenting the understanding of intervention effects, and informing therapeutic decision making.

OBJECTIVE: This study aimed to present a technical framework that supports the automated analysis of both types of …

The Mycl And Mxd1 Transcription Factors Regulate The Fitness Of Murine Dendritic Cells, David A. Anderson Iii, Theresa L. Murphy, Robert N. Eisenman, Kenneth M. Murphy

Open Access Publications

No abstract provided.

Hematopoietic Cell Transplantation In Patients With Primary Immune Regulatory Disorders (Pird): A Primary Immune Deficiency Treatment Consortium (Pidtc) Survey, Alice Y. Chan, Jeffrey J. Bednarski, Megan A. Cooper, Shalini Shenoy, Et Al

Open Access Publications

No abstract provided.

In Vivo Assessment Of Supra-Cervical Fetal Membrane By Mri 3d Ciss: A Preliminary Study, Wenxu Qi, Peinan Zhao, Wei Wang, Zhexian Sun, Xiao Ma, Hui Wang, Wenjie Wu, Zichao Wen, Zulfia Kisrieva-Ware, Pamela K Woodard, Qing Wang, Robert C Mckinstry, Yong Wang

Open Access Publications

In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery.

Fhir Genomics: Enabling Standardization For Precision Medicine Use Cases, Gil Alterovitz, Bret Heale, James Jones, David Kreda, Fan Lin, Lei Liu, Xin Liu, Kenneth D. Mandl, David W. Poloway, Rachel Ramoni, Alex Wagner, Jeremy L. Warner

Open Access Publications

No abstract provided.

Evaluating Circadian Dysfunction In Mouse Models Of Alzheimer's Disease: Where Do We Stand?, Patrick W Sheehan, Erik S Musiek

Open Access Publications

Circadian dysfunction has been described in patients with symptomatic Alzheimer's disease (AD), as well as in presymptomatic phases of the disease. Modeling this circadian dysfunction in mouse models would provide an optimal platform for understanding mechanisms and developing therapies. While numerous studies have examined behavioral circadian function, and in some cases clock gene oscillation, in mouse models of AD, the results are variable and inconsistent across models, ages, and conditions. Ultimately, circadian changes observed in APP/PS1 models are inconsistent across studies and do not always replicate circadian phenotypes observed in human AD. Other models, including the 3xTG mouse, tau transgenic …

Cns Microrna Profles: A Database For Cell Type Enriched Microrna Expression Across The Mouse Central Nervous System, Nathan Pomper, Yating Liu, Mariah L. Hoye, Joseph D. Dougherty, Timothy M. Miller

Open Access Publications

No abstract provided.

Label-Free High-Throughput Photoacoustic Tomography Of Suspected Circulating Melanoma Tumor Cells In Patients In Vivo, Pengfei Hai, Yuan Qu, Yang Li, Liren Zhu, Leonid Shmuylovich, Lynn A. Cornelius, Lihong V. Wang

Open Access Publications

No abstract provided.

Gastric Cancer With Radiographically Occult Metastatic Disease: Biology, Challenges, And Diagnostic Approaches, Aravind Sanjeevaiah, Haeseong Park, Benjamin Fangman, Matthew Porembka

Open Access Publications

Gastric adenocarcinoma is an aggressive cancer that demonstrates heterogeneous biology depending on patient ethnicity, tumor location, tumor type, and genetic profile. It remains the third leading cause of cancer deaths worldwide and was estimated to result in 782,000 deaths in 2018. Challenges exist in accurately assessing the disease burden, as available radiological staging often underestimates metastatic disease. This diagnostic handicap, along with the poor understanding of the heterogeneous biology of gastric cancer, has hindered the development of effective therapeutic solutions and thus halted improvement in patient outcomes over the last few decades. The management of occult peritoneal disease is complicated, …

The Global And National Burden Of Chronic Kidney Disease Attributable To Ambient Fine Particulate Matter Air Pollution: A Modelling Study, Benjamin Bowe, Elena Artimovich, Yan Xie, Yan Yan, Miao Cai, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Identification Of The Growth Factor-Binding Sequence In The Extracellular Matrix Protein Magp-1, Thomas J. Broekelmann, Nicholas K. Bodmer, Robert P. Mecham

Open Access Publications

No abstract provided.

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived Β Cells, Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Jeffrey R Millman

Open Access Publications

Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first

Androgen-Influenced Polarization Of Activin A-Producing Macrophages Accompanies Post-Pyelonephritic Renal Scarring, Teri N. Hreha, Christina A. Collins, Allyssa L. Daugherty, Jessie M. Griffith, Keith A. Hruska, David A. Hunstad

Open Access Publications

No abstract provided.

Low Burden Strategies Are Needed To Reduce Smoking In Rural Healthcare Settings: A Lesson From Cancer Clinics, Alex T Ramsey, Timothy B Baker, Giang Pham, Faith Stoneking, Nina Smock, Graham A Colditz, Aimee S James, Jingxia Liu, Laura J Bierut, Li-Shiun Chen

Open Access Publications

Rural populations face significant smoking-related health disparities, such as a higher prevalence of lung cancer and cancer mortality, higher prevalence of smoking, and lower likelihood of receiving cessation treatment than urban counterparts. A significant proportion of health disparities in rural populations could be eliminated with low-barrier, easy-access treatment delivery methods for smoking cessation. In this study, we assessed treatment engagement among patients in rural and urban settings. Then, we examined the effect of an electronic health record-based smoking cessation module on patient receipt of evidence-based cessation care. As part of a quality improvement project, we retrospectively observed 479,798 unique patients …

Dual Threshold Optimization And Network Inference Reveal Convergent Evidence From Tf Binding Locations And Tf Perturbation Responses, Yiming Kang, Nikhil R Patel, Christian Shively, Pamela Samantha Recio, Xuhua Chen, Bernd J Wranik, Griffin Kim, R Scott Mcisaac, Robi Mitra, Michael R Brent

Open Access Publications

A high-confidence map of the direct, functional targets of each transcription factor (TF) requires convergent evidence from independent sources. Two significant sources of evidence are TF binding locations and the transcriptional responses to direct TF perturbations. Systematic data sets of both types exist for yeast and human, but they rarely converge on a common set of direct, functional targets for a TF. Even the few genes that are both bound and responsive may not be direct functional targets. Our analysis shows that when there are many nonfunctional binding sites and many indirect targets, nonfunctional sites are expected to occur in …

Cryptococcus Neoformans Evades Pulmonary Immunity By Modulating Xylose Precursor Transport, Lucy X. Li, Camaron R. Hole, Javier Rangel-Moreno, Shabaana A. Khader, Tamara L. Doering

Open Access Publications

No abstract provided.

A Mobile Health App For The Collection Of Functional Outcomes After Inpatient Stroke Rehabilitation: Pilot Randomized Controlled Trial, Li Li, Jia Huang, Jingsong Wu, Cai Jiang, Shanjia Chen, Guanli Xie, Jinxin Ren, Jing Tao, Chetwyn C H Chan, Lidian Chen, Alex W K Wong

Open Access Publications

BACKGROUND: Monitoring the functional status of poststroke patients after they transition home is significant for rehabilitation. Mobile health (mHealth) technologies may provide an opportunity to reach and follow patients post discharge. However, the feasibility and validity of functional assessments administered by mHealth technologies are unknown.

OBJECTIVE: This study aimed to evaluate the feasibility, validity, and reliability of functional assessments administered through the videoconference function of a mobile phone-based app compared with administration through the telephone function in poststroke patients after rehabilitation hospitalization.

METHODS: A randomized controlled trial was conducted in a rehabilitation hospital in Southeast China. Participants were randomly assigned …

Environmental Remodeling Of Human Gut Microbiota And Antibiotic Resistome In Livestock Farms, Jian Sun, Alaric W. D'Souza, Manish Boolchandani, Gautam Dantas, Et Al.

Open Access Publications

No abstract provided.

Genetic Aetiology Of Self-Harm Ideation And Behaviour, Adrian I. Campos, Karin J. H. Verweij, Dixie J. Statham, Pamela A. F. Madden, Dominique F. Maciejewski, Katrina A. S. Davis, Ann John, Matthew Hotopf, Andrew C. Heath, Nicholas G. Martin, Miguel E. Rentería

Open Access Publications

No abstract provided.

Long-Term Employment Outcomes Among Female Cancer Survivors, Christine C Ekenga, Eunsun Kwon, Borin Kim, Sojung Park

Open Access Publications

Advances in early detection and treatment have led to a growing population of female cancer survivors, many of whom are of working age. We examined the relationship between cancer and long-term (>5 years) employment outcomes in a nationally representative sample of working-age women in the United States. Data from nine waves of the Health and Retirement Study were used to examine employment status and weekly hours worked among cancer survivors (

Inhibition Of Dnaj-Hsp70 Interaction Improves Strength In Muscular Dystrophy, Rocio Bengoechea, Andrew R Findlay, Ankan K Bhadra, Hao Shao, Kevin C Stein, Sara K Pittman, Jil Aw Daw, Jason E Gestwicki, Heather L True, Conrad C Weihl

Open Access Publications

Dominant mutations in the HSP70 cochaperone DNAJB6 cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. Disease mutations reside within the G/F domain of DNAJB6, but the molecular mechanisms underlying dysfunction are not well understood. Using yeast, cell culture, and mouse models of LGMDD1, we found that the toxicity associated with disease-associated DNAJB6 required its interaction with HSP70 and that abrogating this interaction genetically or with small molecules was protective. In skeletal muscle, DNAJB6 localizes to the Z-disc with HSP70. Whereas HSP70 normally diffused rapidly between the Z-disc …