Digital Commons Network^™

Intracranial Glioma Xenograft Model Rapidly Reestablishes Blood–Brain Barrier Integrity For Longitudinal Imaging Of Tumor Progression Using Fluorescence Molecular Tomography And Contrast Agents, Lemoyne Habimana-Griffin, Dezhuang Ye, Julia Carpenter, Julie Prior, Gail Sudlow, Lynne Marsala, Matthew Mixdorf, Joshua B. Rubin, Hong Chen, Samuel Achilefu

Open Access Publications

No abstract provided.

Postdischarge Antibiotic Use For Prophylaxis Following Spinal Fusion, David K Warren, Katelin B Nickel, Jennifer H Han, Pam Tolomeo, Christopher J Hostler, Katherine Foy, Ian R Banks, Victoria J Fraser, Margaret A Olsen, Cdc Prevention Epicenter Program

Open Access Publications

OBJECTIVE: Despite recommendations to discontinue prophylactic antibiotics after incision closure or <24 hours after surgery, prophylactic antibiotics are continued after discharge by some clinicians. The objective of this study was to determine the prevalence and factors associated with postdischarge prophylactic antibiotic use after spinal fusion.

DESIGN: Multicenter retrospective cohort study.

PATIENTS: This study included patients aged ≥18 years undergoing spinal fusion or refusion between July 2011 and June 2015 at 3 sites. Patients with an infection during the surgical admission were excluded.

METHODS: Prophylactic antibiotics were identified at discharge. Factors associated with postdischarge prophylactic antibiotic use were identified using hierarchical generalized linear models.

RESULTS: In total, 8,652 spinal fusion admissions were included. Antibiotics were prescribed at discharge in 289 admissions (3.3%). The most commonly prescribed antibiotics were trimethoprim/sulfamethoxazole (22.1%), cephalexin (18.8%), and ciprofloxacin (17.1%). …

Induced Remission Of Metastatic Squamous Cell Carcinoma With An Immune Checkpoint Inhibitor In A Patient With Recessive Dystrophic Epidermolysis Bullosa, Karam Khaddour, Emily S. Gorell, Farrokh Dehdashti, Jean Y. Tang, George Ansstas

Open Access Publications

No abstract provided.

Ischemia Reperfusion Injury Provokes Adverse Left Ventricular Remodeling In Dysferlin‑Deficient Hearts Through A Pathway That Involves Tirap Dependent Signaling, Sarah Evans, Carla J. Weinheimer, Attila Kovacs, Jesse W. Williams, Gwendalyn J. Randolph, Wenlong Jiang, Philip M. Barger, Douglas L. Mann

Open Access Publications

No abstract provided.

Contribution Of Immune Cells To Glucocorticoid Receptor Expression In Breast Cancer, Shipra Gandhi, Ahmed Elkhanany, Masanori Oshi, Tao Dai, Mateusz Opyrchal, Hemn Mohammadpour, Elizabeth A Repasky, Kazuaki Takabe

Open Access Publications

Breast cancer (BC) patients experience increased stress with elevated cortisol levels, increasing risk of cancer recurrence. Cortisol binds to a cytoplasmic receptor, glucocorticoid receptor (GR) encoded by GR gene (

Long Non-Coding Rna Rams11 Promotes Metastatic Colorectal Cancer Progression, Jessica M. Silva-Fisher, Ha X. Dang, Nicole M. White, Matthew S. Strand, Bradley A. Krasnick, Emily B. Rozycki, Gejae G. L. Jeffers, Julie G. Grossman, Maureen K. Highkin, Cynthia Tang, Christopher R. Cabanski, Abdallah Eteleeb, Jacqueline Mudd, S. Peter Goedegebuure, Jingqin Luo, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Albert C. Lockhart, Ryan C. Fields, Christopher A. Maher

Open Access Publications

No abstract provided.

Gastrointestinal Neuroendocrine Tumors In Fontan Patients, Corey Vural, Priya Skaria, Louis P. Dehner, Geetika Khanna

Open Access Publications

No abstract provided.

American Society Of Hematology 2020 Guidelines For Sickle Cell Disease: Prevention, Diagnosis, And Treatment Of Cerebrovascular Disease In Children And Adults, M.R. Debaun, L.C. Jordan, A.A. King, J. Schatz, E. Vichinsky, C.K. Fox, R.C. Mckinstry, P. Telfer, M.A. Kraut, L. Daraz, F.J. Kirkham, M.H. Murad

Open Access Publications

No abstract provided.

Self-Reported Sleep Disturbance In Crohn’S Disease Is Not Confrmed By Objective Sleep Measures, Heba N. Iskandar, Emily E. Linan, Ami Patel, Renee Moore, Yi Lasanajak, C. Prakash Gyawali, Gregory S. Sayuk, Matthew A. Ciorba

Open Access Publications

No abstract provided.

Evidence-Based Guidelines For Managing Patients With Primary Er+ Her2− Breast Cancer Deferred From Surgery Due To The Covid-19 Pandemic, Mitch Dowsett, Cynthia X. Ma, Et Al.

Open Access Publications

No abstract provided.

Oncologists’ Communication And Decision-Making Behaviors Affect Perceptions Of Sensitive Information Exchange For Adolescent And Young Adult Patients, Bryan A. Sisk, Karen Fasciano, Susan D. Block, Jennifer W. Mack

Open Access Publications

No abstract provided.

Blood Pressure Profiles In Infants With Hypoxic Ischemic Encephalopathy (Hie), Response To Dopamine, And Association With Brain Injury, Christine Pazandak, Christopher Mcpherson, Maryam Abubakar, Santina Zanelli, Karen Fairchild, Zachary Vesoulis

Open Access Publications

No abstract provided.

Enteric Viral Co-Infections: Pathogenesis And Perspective, Heyde Makimaa, Harshad Ingle, Megan T Baldridge

Open Access Publications

Enteric viral co-infections, infections involving more than one virus, have been reported for a diverse group of etiological agents, including rotavirus, norovirus, astrovirus, adenovirus, and enteroviruses. These pathogens are causative agents for acute gastroenteritis and diarrheal disease in immunocompetent and immunocompromised individuals of all ages globally. Despite virus-virus co-infection events in the intestine being increasingly detected, little is known about their impact on disease outcomes or human health. Here, we review what is currently known about the clinical prevalence of virus-virus co-infections and how co-infections may influence vaccine responses. While experimental investigations into enteric virus co-infections have been limited, we …

Reassessing Rabbit Antithymocyte Globulin Induction In Kidney Transplantation (Rethink): An Analysis Of The North American Pediatric Renal Trials And Collaborative Studies (Naprtcs) Registry, Isa F. Ashoor, Karen Martz, Shirley Galbiati, Robbie A. Beyl, Vikas R. Dharnidharka, Naprtcs Investigators

Open Access Publications

No abstract provided.

Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury And Preserves Left Ventricular Systolic Function In Rats, As Evaluated By 7t Cardiovascular Magnetic Resonance Imaging, Ziqian Xu, Wei Chen, Ruzhi Zhang, Lei Wang, Ridong Chen, Jie Zheng, Fabao Gao

Open Access Publications

No abstract provided.

Wirelessly Controlled, Bioresorbable Drug Delivery Device With Active Valves That Exploit Electrochemically Triggered Crevice Corrosion, Jahyun Koo, Jawad Khalifeh, Ying Yan, Wilson Z Ray, Matthew Macewan, Et Al

Open Access Publications

Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable …

Cell Profiling Of Mouse Acute Kidney Injury Reveals Conserved Cellular Responses To Injury, Yuhei Kirita, Haojia Wu, Kohei Uchimura, Parker C. Wilson, Benjamin D. Humphreys

Open Access Publications

No abstract provided.

Viral-Immune Cell Interactions At The Maternal-Fetal Interface In Human Pregnancy, Elaine L Parker, Rachel B Silverstein, Sonam Verma, Indira U Mysorekar

Open Access Publications

The human decidua and placenta form a distinct environment distinguished for its promotion of immunotolerance to infiltrating semiallogeneic trophoblast cells to enable successful pregnancy. The maternal-fetal interface also successfully precludes transmission of most pathogens. This barrier function occurs in conjunction with a diverse influx of decidual immune cells including natural killer cells, macrophages and T cells. However, several viruses, among other microorganisms, manage to escape destruction by the host adaptive and innate immune system, leading to congenital infection and adverse pregnancy outcomes. In this review, we describe mechanisms of pathogenicity of two such viral pathogens, Human cytomegalovirus (HCMV) and Zika …

Preclinical Single Photon Emission Computed Tomography Of Alpha Particle-Emitting Radium-223, Diane S. Abou, Andrew Rittenbach, Ryan E. Tomlinson, Paige A. Finley, Benjamin Tsui, Brian W. Simons, Abhinav K. Jha, David Ulmert, Ryan C. Riddle, Daniel L. J. Thorek

Open Access Publications

No abstract provided.

Site-Specific Effects Of Neurosteroids On Gaba(A) Receptor Activation And Desensitization, Yusuke Sugasawa, Wayland W.L. Cheng, John R. Bracamontes, Zi-Wei Chen, Lei Wang, Allison L. Germann, Spencer R. Pierce, Thomas C. Senneff, Kathiresan Krishnan, David E. Reichert, Douglas F. Covey, Gustav Akk, Alex S. Evers

Open Access Publications

This study examines how site-specific binding to three identified neurosteroid-binding sites in the α

Affinity-Restricted Memory B Cells Dominate Recall Responses To Heterologous Flaviviruses, Rachel Wong, Julia A. Belk, Jennifer Govero, Jennifer L. Uhrlaub, Dakota Reinartz, Haiyan Zhao, John M. Errico, Lucas D'Souza, Tyler J. Ripperger, Janko Nikolich-Zugich, Mark J. Shlomchik, Ansuman T. Satpathy, Daved H. Fremont, Michael S. Diamond, Deepta Bhattacharya

Open Access Publications

No abstract provided.

Identifying Determinants Of Bacterial Fitness In A Model Of Human Gut Microbial Succession, Lihui Feng, Arjun S. Raman, Matthew C. Hibberd, Jiye Cheng, Nicholas W. Griffin, Yangqing Peng, Semen A. Leyn, Dmitry A. Rodionov, Andrei L. Osterman, Jeffrey I. Gordon

Open Access Publications

No abstract provided.

Integrative Analysis Identifies Candidate Tumor Microenvironment And Intracellular Signaling Pathways That Define Tumor Heterogeneity In Nf1, Jineta Banerjee, Robert J Allaway, Jaclyn N Taroni, Aaron Baker, Xiaochun Zhang, Chang In Moon, Christine A Pratilas, Jaishri O Blakeley, Justin Guinney, Angela Hirbe, Casey S Greene, Sara Jc Gosline

Open Access Publications

Neurofibromatosis type 1 (NF1) is a monogenic syndrome that gives rise to numerous symptoms including cognitive impairment, skeletal abnormalities, and growth of benign nerve sheath tumors. Nearly all NF1 patients develop cutaneous neurofibromas (cNFs), which occur on the skin surface, whereas 40-60% of patients develop plexiform neurofibromas (pNFs), which are deeply embedded in the peripheral nerves. Patients with pNFs have a ~10% lifetime chance of these tumors becoming malignant peripheral nerve sheath tumors (MPNSTs). These tumors have a severe prognosis and few treatment options other than surgery. Given the lack of therapeutic options available to patients with these tumors, identification …

Contacting Domains Segregate A Lipid Transporter From A Solute Transporter In The Malarial Host–Parasite Interface, Matthias Garten, Josh R. Beck, Robyn Roth, Tatyana Tenkova-Heuser, John Heuser, Eva S. Istvan, Christopher K.E. Bleck, Daniel E. Goldberg, Joshua Zimmerberg

Open Access Publications

No abstract provided.

American Society Of Hematology 2020 Guidelines For Management Of Venous Thromboembolism: Treatment Of Deep Vein Thrombosis And Pulmonary Embolism, Thomas L. Ortel, Suresh Vedantham, Et Al.

Open Access Publications

No abstract provided.

The At(N) Framework For Alzheimer's Disease In Adults With Down Syndrome, Michael S Rafii, Beau M Ances, Et Al

Open Access Publications

The National Institute on Aging in conjunction with the Alzheimer's Association (NIA-AA) recently proposed a biological framework for defining the Alzheimer's disease (AD) continuum. This new framework is based upon the key AD biomarkers (amyloid, tau, neurodegeneration, AT[N]) instead of clinical symptoms and represents the latest understanding that the pathological processes underlying AD begin decades before the manifestation of symptoms. By using these same biomarkers, individuals with Down syndrome (DS), who are genetically predisposed to developing AD, can also be placed more precisely along the AD continuum. The A/T(N) framework is therefore thought to provide an objective manner by which …

Chemical Inhibition Of Papd5/7 Rescues Telomerase Function And Hematopoiesis In Dyskeratosis Congenita, Siddharth Shukla, Ho-Chang Jeong, Christopher M. Sturgeon, Roy Parker, Luis Francisco Zirnberger Batista

Open Access Publications

No abstract provided.

Structural Characterization Of Tssl From Acinetobacter Baumannii: A Key Component Of The Type Vi Secretion System, Federico M Ruiz, Juvenal Lopez, C Gastón Ferrara, Elena Santillana, Yanis R Espinosa, Mario F Feldman, Antonio Romero

Open Access Publications

The type VI secretion system (T6SS) is a complex molecular nanomachine used by Gram-negative bacteria to deliver diverse effectors into adjacent cells. A membrane complex (MC) anchors this transport system to the bacterial cell wall. One of the proteins forming the MC is TssL, a cytoplasmic protein bound to the inner membrane through a single transmembrane helix. Here, we report the structure of the cytoplasmic N-terminal region of TssL from

Relationships Between Big-Five Personality Factors And Alzheimer's Disease Pathology In Autosomal Dominant Alzheimer's Disease, Andrew J Aschenbrenner, Jennifer Petros, Eric Mcdade, Guoqiao Wang, David A Balota, Tammie Ls Benzinger, Carlos Cruchaga, Chengjie Xiong, Richard Perrin, Anne M Fagan, John C Morris, Randall Bateman, Jason Hassenstab, Et Al

Open Access Publications

Introduction: Changes in personality characteristics are associated with the onset of symptoms in Alzheimer's disease (AD) and may even precede clinical diagnosis. However, personality changes caused by disease progression can be difficult to separate from changes that occur with normal aging. The Dominantly Inherited Alzheimer Network (DIAN) provides a unique cohort in which to relate measures of personality traits to in vivo markers of disease in a much younger sample than in typical late onset AD.

Methods: Personality traits measured with the International Personality Item Pool at baseline from DIAN participants were analyzed as a function of estimated years to …

Glibenclamide Reverses Cardiovascular Abnormalities Of Cantu Syndrome Driven By Katp Channel Overactivity, Conor Mcclenaghan, Yan Huang, Zihan Yan, Theresa M Harter, Carmen M Halabi, Rod Chalk, Attila Kovacs, Gijs Van Haaften, Maria S Remedi, Colin G Nichols

Open Access Publications

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) KATP channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abnormalities. There is currently no targeted therapy, and it is unknown whether cardiovascular features can be reversed once manifest. Using combined transgenic and pharmacological approaches in a knockin mouse model of CS, we have shown that reversal of vascular and cardiac phenotypes can be achieved by genetic downregulation of KATP channel activity specifically in VSM, and by chronic administration …