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Articles 2611 - 2640 of 11655
Full-Text Articles in Entire DC Network
A Framework For Advancing Our Understanding Of Cancer-Associated Fibroblasts, Erik Sahai, David G. Denardo, Sheila Stewart, Et Al.
A Framework For Advancing Our Understanding Of Cancer-Associated Fibroblasts, Erik Sahai, David G. Denardo, Sheila Stewart, Et Al.
Open Access Publications
No abstract provided.
Platelet Α-Granules Are Required For Occlusive High-Shear-Rate Thrombosis, Dongjune A. Kim, Katrina J. Ashworth, Jorge Di Paola, David N. Ku
Platelet Α-Granules Are Required For Occlusive High-Shear-Rate Thrombosis, Dongjune A. Kim, Katrina J. Ashworth, Jorge Di Paola, David N. Ku
Open Access Publications
No abstract provided.
A Phase Ii Study Of Glembatumumab Vedotin For Metastatic Uveal Melanoma, Merve Hasanov, Matthew J Rioth, Kari Kendra, Leonel Hernandez-Aya, Richard W Joseph, Stephen Williamson, Sunandana Chandra, Keisuke Shirai, Christopher D Turner, Karl Lewis, Elizabeth Crowley, Jeffrey Moscow, Brett Carter, Sapna Patel
A Phase Ii Study Of Glembatumumab Vedotin For Metastatic Uveal Melanoma, Merve Hasanov, Matthew J Rioth, Kari Kendra, Leonel Hernandez-Aya, Richard W Joseph, Stephen Williamson, Sunandana Chandra, Keisuke Shirai, Christopher D Turner, Karl Lewis, Elizabeth Crowley, Jeffrey Moscow, Brett Carter, Sapna Patel
Open Access Publications
Glembatumumab vedotin (CDX-011, GV) is a fully human Immunoglobulin G2 monoclonal antibody directed against glycoprotein NMB coupled via a peptide linker to monomethyl auristatin E (MMAE), a potent cytotoxic microtubule inhibitor. This phase II study evaluated the overall response rate and safety of GV, glycoprotein NMB (GPNMB) expression, and survival in patients with metastatic uveal melanoma. Eligible patients with metastatic uveal melanoma who had not previously been treated with chemotherapy received GV 1.9 mg/kg every three weeks. The primary endpoint was the objective response rate (ORR). Secondary endpoints included GPNMB expression, progression-free survival (PFS), overall survival (OS), and toxicity analysis. …
Macrophage Secretion Of Mir-106b-5p Causes Renin-Dependent Hypertension, J. Oh, S. J. Matkovich, A. E. Riek, S. M. Bindom, J. S. Shao, R.D. Head, R. A. Barve, M. S. Sands, G. Carmeliet, P. Osei-Owusu, R.H. Knutsen, H. Zhang, K. J. Blumer, C. G. Nichols, R. P. Mecham, Á Baldán, B. A. Benitez, M. L. Sequeira-Lopez, R. A. Gomez, C. Bernal-Mizrachi
Macrophage Secretion Of Mir-106b-5p Causes Renin-Dependent Hypertension, J. Oh, S. J. Matkovich, A. E. Riek, S. M. Bindom, J. S. Shao, R.D. Head, R. A. Barve, M. S. Sands, G. Carmeliet, P. Osei-Owusu, R.H. Knutsen, H. Zhang, K. J. Blumer, C. G. Nichols, R. P. Mecham, Á Baldán, B. A. Benitez, M. L. Sequeira-Lopez, R. A. Gomez, C. Bernal-Mizrachi
Open Access Publications
No abstract provided.
Retrospective Evaluation Of Whole Exome And Genome Mutation Calls In 746 Cancer Samples, Matthew H. Bailey, William U. Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Sean Kelso, Mc3 Working Group, Pcawg Novel Somatic Mutation Calling Methods Working Group, Gordon Saksena, Kyle Ellrott, Michael C. Wendl, David A. Wheeler, Gad Getz, Jared T. Simpson, Mark B. Gerstein, Li Ding, Pcawg Consortium
Retrospective Evaluation Of Whole Exome And Genome Mutation Calls In 746 Cancer Samples, Matthew H. Bailey, William U. Meyerson, Lewis Jonathan Dursi, Liang-Bo Wang, Guanlan Dong, Wen-Wei Liang, Amila Weerasinghe, Shantao Li, Sean Kelso, Mc3 Working Group, Pcawg Novel Somatic Mutation Calling Methods Working Group, Gordon Saksena, Kyle Ellrott, Michael C. Wendl, David A. Wheeler, Gad Getz, Jared T. Simpson, Mark B. Gerstein, Li Ding, Pcawg Consortium
Open Access Publications
No abstract provided.
Concern Of Photosensitive Seizures Evoked By 3d Video Displays Or Virtual Reality Headsets In Children: Current Perspective, Lawrence Tychsen, Liu Lin Thio
Concern Of Photosensitive Seizures Evoked By 3d Video Displays Or Virtual Reality Headsets In Children: Current Perspective, Lawrence Tychsen, Liu Lin Thio
Open Access Publications
This review assesses the risk of a photic-induced seizure in a child during viewing of 3D (binocular 3 dimensional, stereoscopic) movies or games, either on standard video displays or when wearing a virtual reality (VR) headset. Studies published by pediatric epilepsy experts emphasize the low risk of 3D viewing even for children with known photosensitive epilepsy (PSE). The low incidence of PSE is noteworthy because the number of hours devoted to 2D or 3D screen viewing and/or VR headset use by children worldwide has increased markedly over the last decade. The medical literature does not support the notion that VR …
The Nemp Family Supports Metazoan Fertility And Nuclear Envelope Stiffness, Yonit Tsatskis, Ariz Mohammad, Karen Krchma, Jun Wu, Didier Hodzic, Daniel Potter, Tim Schedl, Kyunghee Choi, Helen Mcneill, Et Al
The Nemp Family Supports Metazoan Fertility And Nuclear Envelope Stiffness, Yonit Tsatskis, Ariz Mohammad, Karen Krchma, Jun Wu, Didier Hodzic, Daniel Potter, Tim Schedl, Kyunghee Choi, Helen Mcneill, Et Al
Open Access Publications
Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in
Esophageal Baseline Impedance From High-Resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From Ph-Impedance Monitoring, Anthony Horton, Brian Sullivan, Katie Charles, Thasha Mcintosh, Andrea Davis, Ziad Gellad, Rahul Shimpi, C Prakash Gyawali, Amit Patel
Esophageal Baseline Impedance From High-Resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From Ph-Impedance Monitoring, Anthony Horton, Brian Sullivan, Katie Charles, Thasha Mcintosh, Andrea Davis, Ziad Gellad, Rahul Shimpi, C Prakash Gyawali, Amit Patel
Open Access Publications
No abstract provided.
Unique Growth Pathway In Solution−Solid−Solid Nanowires: Cubic To Hexagonal Phase Transformation, Yi-Hsin Liu, Ho-Ying Chen, Hsiu-Fang Fan, Yu-Hsien Chen, Fudong Wang
Unique Growth Pathway In Solution−Solid−Solid Nanowires: Cubic To Hexagonal Phase Transformation, Yi-Hsin Liu, Ho-Ying Chen, Hsiu-Fang Fan, Yu-Hsien Chen, Fudong Wang
Open Access Publications
No abstract provided.
Diet Quality, Food Groups And Nutrients Associated With The Gut Microbiota In A Nonwestern Population, Ángela S García-Vega, Vanessa Corrales-Agudelo, Alejandro Reyes, Juan S Escobar
Diet Quality, Food Groups And Nutrients Associated With The Gut Microbiota In A Nonwestern Population, Ángela S García-Vega, Vanessa Corrales-Agudelo, Alejandro Reyes, Juan S Escobar
Open Access Publications
Diet plays an important role in shaping gut microbiota. However, much remains to be learned regarding this association. We analyzed dietary intake and gut microbiota in a community-dwelling cohort of 441 Colombians. Diet quality, intake of food groups and nutrient consumption were paired with microbial diversity and composition using linear regressions, Procrustes analyses and a random-forest machine-learning algorithm. Analyses were adjusted for potential confounders, including the five cities from where the participants originated, sex (male, female), age group (18-40 and 41-62 years), BMI (lean, overweight, obese) and socioeconomic status. Microbial diversity was higher in individuals with increased intake of nutrients …
Hearing Loss In Mucopolysaccharidoses: Current Knowledge And Future Directions, Jeremy Wolfberg, Keerthana Chintalapati, Shunji Tomatsu, Kyoko Nagao
Hearing Loss In Mucopolysaccharidoses: Current Knowledge And Future Directions, Jeremy Wolfberg, Keerthana Chintalapati, Shunji Tomatsu, Kyoko Nagao
Open Access Publications
Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by a deficiency of one of the enzymes involved in the degradation of glycosaminoglycans. Hearing loss is a common clinical presentation in MPS. This paper reviews the literature on hearing loss for each of the seven recognized subtypes of MPS. Hearing loss was found to be common in MPS I, II, III, IVA, VI, and VII, and absent from MPS IVB and MPS IX. MPS VI presents primarily with conductive hearing loss, while the other subtypes (MPS I, MPS II, MPS III, MPS IVA, and MPS VII) can present with …
Development And Evaluation Of A Computerized Clinical Outcome Assessment Tool For Head And Neck Cancer Patients, Ching-Rong Lin, Kang-Hsing Fan, Chien-Yu Lin, Tsung-Min Hung, Bing-Shen Huang, Eric Yen-Chao Chen, Chung-Jan Kang, Shiang-Fu Huang, Joseph Tung-Chieh Chang, Chih-Hung Chang
Development And Evaluation Of A Computerized Clinical Outcome Assessment Tool For Head And Neck Cancer Patients, Ching-Rong Lin, Kang-Hsing Fan, Chien-Yu Lin, Tsung-Min Hung, Bing-Shen Huang, Eric Yen-Chao Chen, Chung-Jan Kang, Shiang-Fu Huang, Joseph Tung-Chieh Chang, Chih-Hung Chang
Open Access Publications
No abstract provided.
Tert, A Promoter Of Cns Malignancies, Bhuvic Patel, Rukayat Taiwo, Albert H. Kim, Gavin P. Dunn
Tert, A Promoter Of Cns Malignancies, Bhuvic Patel, Rukayat Taiwo, Albert H. Kim, Gavin P. Dunn
Open Access Publications
As cells replicate their DNA during mitosis, telomeres are shortened due to the inherent limitations of the DNA replication process. Maintenance of telomere length is critical for cancer cells to overcome cellular senescence induced by telomere shortening. Telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of telomerase, an RNA-dependent DNA polymerase that lengthens telomeric DNA to maintain telomere homeostasis.
Biased Opioid Ligands, Abdelfattah Faouzi, Balazs R Varga, Susruta Majumdar
Biased Opioid Ligands, Abdelfattah Faouzi, Balazs R Varga, Susruta Majumdar
Open Access Publications
Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities. Opioids act through the opioid receptors, the family of G-protein coupled receptors (GPCRs) that mediate pain relief through both the central and peripheral nervous systems. Four types of opioid receptors have been described, including the μ-opioid receptor (MOR), κ-opioid receptor (KOR), δ-opioid receptor (DOR), and the nociceptin opioid peptide receptor (NOP receptor). Despite the proven success of opioids in treating pain, there are still some …
When (Almost) Everyone Is Above Average: A Critical Analysis Of American Orthopaedic Association Committee Of Residency Directors Standardized Letters Of Recommendation, Paul M. Inclan, Alisa A. Cooperstein, Alexa Powers, Christopher J. Dy, Sandra E. Klein
When (Almost) Everyone Is Above Average: A Critical Analysis Of American Orthopaedic Association Committee Of Residency Directors Standardized Letters Of Recommendation, Paul M. Inclan, Alisa A. Cooperstein, Alexa Powers, Christopher J. Dy, Sandra E. Klein
Open Access Publications
No abstract provided.
Co-Occurrence Of Campylobacter Species In Children From Eastern Ethiopia, And Their Association With Environmental Enteric Dysfunction, Diarrhea, And Host Microbiome, Yitagele Terefe, Mark J Manary, Maria Isabel Ordiz, Et Al
Co-Occurrence Of Campylobacter Species In Children From Eastern Ethiopia, And Their Association With Environmental Enteric Dysfunction, Diarrhea, And Host Microbiome, Yitagele Terefe, Mark J Manary, Maria Isabel Ordiz, Et Al
Open Access Publications
High
Multi-System Factors Associated With Metatarsophalangeal Joint Deformity In Individuals With Type 2 Diabetes, Jennifer A Zellers, Michael J Mueller, Paul K Commean, Ling Chen, Hyo-Jung Jeong, Mary K Hastings
Multi-System Factors Associated With Metatarsophalangeal Joint Deformity In Individuals With Type 2 Diabetes, Jennifer A Zellers, Michael J Mueller, Paul K Commean, Ling Chen, Hyo-Jung Jeong, Mary K Hastings
Open Access Publications
The underlying factors contributing to metatarsophalangeal joint deformity, a known precursor to skin breakdown in individuals with diabetes mellitus (DM), is likely to involve multiple body systems. The purpose of this cross-sectional study was to identify multi-system factors associated with metatarsophalangeal joint deformity in individuals with type 2 DM and peripheral neuropathy (
Maternal Activation Of The Egfr Prevents Translocation Of Gut-Residing Pathogenic Escherichia Coli In A Model Of Late-Onset Neonatal Sepsis, Kathryn A. Knoop, Paige E. Coughlin, Alexandria N. Floyd, I. Malick Ndao, Carla Hall-Moore, Nurmohammad Shaikh, Andrew J. Gasparrini, Brigida Rusconi, Marilyn Escobedo, Misty Good, Barbara B. Warner, Phillip I. Tarr, Rodney D. Newberry
Maternal Activation Of The Egfr Prevents Translocation Of Gut-Residing Pathogenic Escherichia Coli In A Model Of Late-Onset Neonatal Sepsis, Kathryn A. Knoop, Paige E. Coughlin, Alexandria N. Floyd, I. Malick Ndao, Carla Hall-Moore, Nurmohammad Shaikh, Andrew J. Gasparrini, Brigida Rusconi, Marilyn Escobedo, Misty Good, Barbara B. Warner, Phillip I. Tarr, Rodney D. Newberry
Open Access Publications
No abstract provided.
Genomics Of Mpnst (Gem) Consortium: Rationale And Study Design For Multi-Omic Characterization Of Nf1-Associated And Sporadic Mpnsts, David T Miller, Angela C Hirbe, Et Al
Genomics Of Mpnst (Gem) Consortium: Rationale And Study Design For Multi-Omic Characterization Of Nf1-Associated And Sporadic Mpnsts, David T Miller, Angela C Hirbe, Et Al
Open Access Publications
The Genomics of Malignant Peripheral Nerve Sheath Tumor (GeM) Consortium is an international collaboration focusing on multi-omic analysis of malignant peripheral nerve sheath tumors (MPNSTs), the most aggressive tumor associated with neurofibromatosis type 1 (NF1). Here we present a summary of current knowledge gaps, a description of our consortium and the cohort we have assembled, and an overview of our plans for multi-omic analysis of these tumors. We propose that our analysis will lead to a better understanding of the order and timing of genetic events related to MPNST initiation and progression. Our ten institutions have assembled 96 fresh frozen …
Applying Dimensional Psychopathology: Transdiagnostic Associations Among Regional Homogeneity, Leptin And Depressive Symptoms, Yan-Ge Wei, Jia Duan, Fay Y. Womer, Yue Zhu, Zhiyang Yin, Lingling Cui, Chao Li, Zhuang Liu, Shengnan Wei, Xiaowei Jiang, Yanbo Zhang, Xizhe Zhang, Yanqing Tang, Fei Wang
Applying Dimensional Psychopathology: Transdiagnostic Associations Among Regional Homogeneity, Leptin And Depressive Symptoms, Yan-Ge Wei, Jia Duan, Fay Y. Womer, Yue Zhu, Zhiyang Yin, Lingling Cui, Chao Li, Zhuang Liu, Shengnan Wei, Xiaowei Jiang, Yanbo Zhang, Xizhe Zhang, Yanqing Tang, Fei Wang
Open Access Publications
No abstract provided.
Gait Asymmetry, And Bilateral Coordination Of Gait During A Six‑Minute Walk Test In Persons With Multiple Sclerosis, Meir Plotnik, Joanne M. Wagner, Gautam Adusumilli, Amihai Gottlieb, Robert T. Naismith
Gait Asymmetry, And Bilateral Coordination Of Gait During A Six‑Minute Walk Test In Persons With Multiple Sclerosis, Meir Plotnik, Joanne M. Wagner, Gautam Adusumilli, Amihai Gottlieb, Robert T. Naismith
Open Access Publications
No abstract provided.
In Situ Detection Of Endogenous Hiv Activation By Dynamic Nuclear Polarization Nmr And Flow Cytometry, Sarah A Overall, Lauren E Price, Brice J Albert, Chukun Gao, Nicholas Alaniva, Patrick T Judge, Erika L Sesti, Paul A Wender, George B Kyei, Alexander B Barnes
In Situ Detection Of Endogenous Hiv Activation By Dynamic Nuclear Polarization Nmr And Flow Cytometry, Sarah A Overall, Lauren E Price, Brice J Albert, Chukun Gao, Nicholas Alaniva, Patrick T Judge, Erika L Sesti, Paul A Wender, George B Kyei, Alexander B Barnes
Open Access Publications
We demonstrate for the first time in-cell dynamic nuclear polarization (DNP) in conjunction with flow cytometry sorting to address the cellular heterogeneity of in-cell samples. Utilizing a green fluorescent protein (GFP) reporter of HIV reactivation, we correlate increased
Non-Conventional Treatments For Conventional Chondrosarcoma, Varun Monga, Hariharasudan Mani, Angela Hirbe, Mohammed Milhem
Non-Conventional Treatments For Conventional Chondrosarcoma, Varun Monga, Hariharasudan Mani, Angela Hirbe, Mohammed Milhem
Open Access Publications
Chondrosarcomas are the most common malignant tumors of the cartilage, are seen predominantly in adults, and have varied clinical behavior. The majority of them affect the medullary canal of long bones and pelvic bones. The prognosis of chondrosarcoma is closely related to histological grading; however, the grading is subject to interobserver variability. Conventional chondrosarcomas are overall considered to be chemotherapy- and radiation-resistant, resulting in limited treatment options. The majority of advanced conventional chondrosarcomas are treated with chemotherapy without any survival benefit. Recent studies have evaluated molecular genetic findings which have improved the understanding of chondrosarcoma biology. Newer therapeutic targets are …
Individualization Of Attention-Deficit/Hyperactivity Disorder Treatment: Pharmacotherapy Considerations By Age And Co-Occurring Conditions, Greg W Mattingly, Joshua Wilson, Leticia Ugarte, Paul Glaser
Individualization Of Attention-Deficit/Hyperactivity Disorder Treatment: Pharmacotherapy Considerations By Age And Co-Occurring Conditions, Greg W Mattingly, Joshua Wilson, Leticia Ugarte, Paul Glaser
Open Access Publications
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that manifests in childhood and can persist into adolescence and adulthood. Impairments associated with ADHD can impact quality of life, social interactions, and increase the risk of morbidity and mortality; however, for many patients, effective treatment can lessen these effects. Pharmacotherapy with stimulants or nonstimulants is recommended in conjunction with psychosocial therapy for most patients. Determining the optimal pharmacotherapy can be complex, and the clinician needs to consider many factors such as the patient's age, comorbidities, and lifestyle. Furthermore, the needs of the patient with ADHD will change over time, with specific challenges …
Methylation-Directed Glycosylation Of Chromatin Factors Represses Retrotransposon Promoters, Mathieu Boulard, Sofia Rucli, John R. Edwards, Timothy H. Bestor
Methylation-Directed Glycosylation Of Chromatin Factors Represses Retrotransposon Promoters, Mathieu Boulard, Sofia Rucli, John R. Edwards, Timothy H. Bestor
Open Access Publications
No abstract provided.
Nanotherapy Delivery Of C-Myc Inhibitor Targets Protumor Macrophages And Preserves Antitumor Macrophages In Breast Cancer, Alison K. Esser, Michael H. Ross, Francesca Fontana, Xinming Su, Ariel Gabay, Gregory C. Fox, Yalin Xu, Jingyu Xiang, Anne H. Schmieder, Xiaoxia Yang, Grace Cui, Michael Scott, Samuel Achilefu, Jay Chauhan, Steven Fletcher, Gregory M. Lanza, Katherine N. Weilbaecher
Nanotherapy Delivery Of C-Myc Inhibitor Targets Protumor Macrophages And Preserves Antitumor Macrophages In Breast Cancer, Alison K. Esser, Michael H. Ross, Francesca Fontana, Xinming Su, Ariel Gabay, Gregory C. Fox, Yalin Xu, Jingyu Xiang, Anne H. Schmieder, Xiaoxia Yang, Grace Cui, Michael Scott, Samuel Achilefu, Jay Chauhan, Steven Fletcher, Gregory M. Lanza, Katherine N. Weilbaecher
Open Access Publications
No abstract provided.
Evaluation Of Naturalistic Driving Behavior Using In-Vehicle Monitoring Technology In Preclinical And Early Alzheimer's Disease, Jennifer D Davis, Ganesh M Babulal, George D Papandonatos, Erin M Burke, Christopher B Rosnick, Brian R Ott, Catherine M Roe
Evaluation Of Naturalistic Driving Behavior Using In-Vehicle Monitoring Technology In Preclinical And Early Alzheimer's Disease, Jennifer D Davis, Ganesh M Babulal, George D Papandonatos, Erin M Burke, Christopher B Rosnick, Brian R Ott, Catherine M Roe
Open Access Publications
Cognitive impairment is a significant risk factor for hazardous driving among older drivers with Alzheimer's dementia, but little is known about how the driving behavior of mildly symptomatic compares with those in the preclinical, asymptomatic phase of Alzheimer's disease (AD). This study utilized two in-car technologies to characterize driving behavior in symptomatic and preclinical AD. The goals of this pilot study were to (1) describe unsafe driving behaviors in individuals with symptomatic early AD using G-force triggered video capture and (2) compare the driving habits of these symptomatic AD drivers to two groups of cognitively normal drivers, those with and …
Genotype-Phenotype Correlations In Children With Hht, Alexandra Kilian, Andrew J White, Murali M Chakinala, Et Al
Genotype-Phenotype Correlations In Children With Hht, Alexandra Kilian, Andrew J White, Murali M Chakinala, Et Al
Open Access Publications
Hereditary hemorrhagic telangiectasia (HHT), a rare autosomal dominant disease mostly caused by mutations in three known genes (
Considerations In Preparative Regimen Selection To Minimize Rejection In Pediatric Hematopoietic Transplantation In Non-Malignant Diseases, Robert J Hayashi
Considerations In Preparative Regimen Selection To Minimize Rejection In Pediatric Hematopoietic Transplantation In Non-Malignant Diseases, Robert J Hayashi
Open Access Publications
The variables that influence the selection of a preparative regimen for a pediatric hematopoietic stem cell transplant procedure encompasses many issues. When one considers this procedure for non-malignant diseases, components in a preparative regimen that were historically developed to reduce malignant tumor burden may be unnecessary. The primary goal of the procedure in this instance becomes engraftment with the establishment of normal hematopoiesis and a normal immune system. Overcoming rejection becomes the primary priority, but pursuit of this goal cannot neglect organ toxicity, or post-transplant morbidity such as graft-versus-host disease or life threatening infections. With the improvements in supportive care, …
Myeloid-Specific Asxl2 Deletion Limits Diet-Induced Obesity By Regulating Energy Expenditure, Wei Zou, Nidhi Rohatgi, Jonathan R Brestoff, John R Moley, Yongjia Li, Jesse W Williams, Yael Alippe, Hua Pan, Terri A Pietka, Gabriel Mbalaviele, Elizabeth P Newberry, Nicholas O Davidson, Anwesha Dey, Kooresh I Shoghi, Richard D Head, Samuel A Wickline, Gwendalyn J Randolph, Nada A Abumrad, Steven L Teitelbaum
Myeloid-Specific Asxl2 Deletion Limits Diet-Induced Obesity By Regulating Energy Expenditure, Wei Zou, Nidhi Rohatgi, Jonathan R Brestoff, John R Moley, Yongjia Li, Jesse W Williams, Yael Alippe, Hua Pan, Terri A Pietka, Gabriel Mbalaviele, Elizabeth P Newberry, Nicholas O Davidson, Anwesha Dey, Kooresh I Shoghi, Richard D Head, Samuel A Wickline, Gwendalyn J Randolph, Nada A Abumrad, Steven L Teitelbaum
Open Access Publications
We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the …