Digital Commons Network^™

Evaluation Of The Neonatal Sequential Organ Failure Assessment And Mortality Risk In Preterm Infants With Late-Onset Infection, Noa Fleiss, Angela N. Lewis, Krista E. Cooksey, Ameena N. Husain, Misty Good, Et Al

Open Access Publications

Importance: Infection in neonates remains a substantial problem. Advances for this population are hindered by the absence of a consensus definition for sepsis. In adults, the Sequential Organ Failure Assessment (SOFA) operationalizes mortality risk with infection and defines sepsis. The generalizability of the neonatal SOFA (nSOFA) for neonatal late-onset infection-related mortality remains unknown.

Objective: To determine the generalizability of the nSOFA for neonatal late-onset infection-related mortality across multiple sites.

Design, Setting, and Participants: A multicenter retrospective cohort study was conducted at 7 academic neonatal intensive care units between January 1, 2010, and December 31, 2019. Participants included 653 preterm ( …

Best Practices For Fnirs Publications, Meryem A. Yücel, Joseph Culver, Adam Eggebrecht, Et Al.

Open Access Publications

No abstract provided.

The Catalytic Mechanism Of Vitamin K Epoxide Reduction In Acellular Environment, Guomin Shen, Weidong Cui, Qing Cao, Meng Gao, Hongli Liu, Gaigai Su, Michael L. Gross, Weikai Li

Open Access Publications

No abstract provided.

Sex, Apoe4 And Alzheimer’S Disease: Rethinking Drug Discovery In The Era Of Precision Medicine, Manish D. Paranjpe, Jason K. Wang, Yun Zhou

Open Access Publications

No abstract provided.

Inhibition Of The Nlrp3 Inflammasome Prevents Ovarian Aging, José M Navarro-Pando, Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Elena Navarro-Villarán, Mónica Condés-Hervás, María Mundi-Roldan, Jordi Muntané, Antonio J Pérez-Pulido, Pedro Bullon, Chun Wang, Hal M Hoffman, Alberto Sanz, Gabriel Mbalaviele, Bernhard Ryffel, Mario D Cordero

Open Access Publications

Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 …

Intracranial Delivery Of Aav9 Gene Therapy Partially Prevents Retinal Degeneration And Visual Deficits In Cln6-Batten Disease Mice, Katherine A. White, Hemanth R. Nelvagal, Timothy A. Poole, Bin Lu, Tyler B. Johnson, Samantha Davis, Melissa A. Pratt, Jon Brudvig, Ana B. Assis, Shibi Likhite, Kathrin Meyer, Brian K. Kaspar, Jonathan D. Cooper, Shaomei Wang, Jill M. Weimer

Open Access Publications

No abstract provided.

Immunotherapy And Immunotherapy Combinations In Metastatic Castration-Resistant Prostate Cancer, Dhruv Bansal, Melissa A Reimers, Eric M Knoche, Russell K Pachynski

Open Access Publications

Although most prostate cancers are localized, and the majority are curable, recurrences occur in approximately 35% of men. Among patients with prostate-specific antigen (PSA) recurrence and PSA doubling time (PSADT) less than 15 months after radical prostatectomy, prostate cancer accounted for approximately 90% of the deaths by 15 years after recurrence. An immunosuppressive tumor microenvironment (TME) and impaired cellular immunity are likely largely responsible for the limited utility of checkpoint inhibitors (CPIs) in advanced prostate cancer compared with other tumor types. Thus, for immunologically "cold" malignancies such as prostate cancer, clinical trial development has pivoted towards novel approaches to enhance …

Effects Of Dietary Restriction On Neuroinflammation In Neurodegenerative Diseases, Luigi Fontana, Laura Ghezzi, Anne H. Cross, Laura Piccio

Open Access Publications

Recent and accumulating work in experimental animal models and humans shows that diet has a much more pervasive and prominent role than previously thought in modulating neuroinflammatory and neurodegenerative mechanisms leading to some of the most common chronic central nervous system (CNS) diseases. Chronic or intermittent food restriction has profound effects in shaping brain and peripheral metabolism, immunity, and gut microbiome biology. Interactions among calorie intake, meal frequency, diet quality, and the gut microbiome modulate specific metabolic and molecular pathways that regulate cellular, tissue, and organ homeostasis as well as inflammation during normal brain aging and CNS neurodegenerative diseases, including …

An Integrated Approach To Identify New Anti-Filarial Leads To Treat River Blindness, A Neglected Tropical Disease, Rahul Tyagi, Christina A Bulman, Fidelis Cho-Ngwa, Chelsea Fischer, Chris Marcellino, Michelle R Arkin, James H Mckerrow, Case W Mcnamara, Matthew Mahoney, Nancy Tricoche, Shabnam Jawahar, James W Janetka, Sara Lustigman, Judy Sakanari, Makedonka Mitreva

Open Access Publications

Filarial worms cause multiple debilitating diseases in millions of people worldwide, including river blindness. Currently available drugs reduce transmission by killing larvae (microfilariae), but there are no effective cures targeting the adult parasites (macrofilaricides) which survive and reproduce in the host for very long periods. To identify effective macrofilaricides, we carried out phenotypic screening of a library of 2121 approved drugs for clinical use against adult

How The Field Of Infectious Diseases Can Leverage Digital Strategy And Social Media Use During A Pandemic, Jasmine R. Marcelin, Nicolás Cortés-Penfield, Carlos Del Rio, Angel Desai, Ignacio Echenique, Bruno Granwehr, Folake Lawal, Kevin Kuriakose, Dong Heun Lee, Maricar Malinis, Diandra Ruidera, Javeed Siddiqui, Andrej Spec, Talia H. Swartz

Open Access Publications

Rapid information dissemination is critical in a world changing rapidly due to global threats. Ubiquitous internet access has created new methods of information dissemination that are rapid, far-reaching, and universally accessible. However, inaccuracies may accompany rapid information dissemination, and rigorous evaluation of primary data through various forms of peer review is crucial. In an era in which high-quality information can save lives, it is critical that infectious diseases specialists are well versed in digital strategy to effectively disseminate information to colleagues and the community and diminish voices spreading misinformation. In this study, we review how social media can be used …

Ash Isth Nhf Wfh 2021 Guidelines On The Diagnosis Of Von Willebrand Disease, Paula D. James, Jorge Di Paola, Et Al.

Open Access Publications

No abstract provided.

Nav1.3 And Fgf14 Are Primary Determinants Of The Ttx-Sensitive Sodium Current In Mouse Adrenal Chromaffin Cells, Pedro L. Martinez-Espinosa, Chengtao Yang, Xiao-Ming Xia, Christopher J. Lingle

Open Access Publications

Adrenal chromaffin cells (CCs) in rodents express rapidly inactivating, tetrodotoxin (TTX)-sensitive sodium channels. The resulting current has generally been attributed to Nav1.7, although a possible role for Nav1.3 has also been suggested. Nav channels in rat CCs rapidly inactivate via two independent pathways which differ in their time course of recovery. One subpopulation recovers with time constants similar to traditional fast inactivation and the other ∼10-fold slower, but both pathways can act within a single homogenous population of channels. Here, we use Nav1.3 KO mice to probe the properties and molecular components of Nav current in CCs. We find that …

American Society Of Hematology 2021 Guidelines On The Use Of Anticoagulation For Thromboprophylaxis In Patients With Covid-19, Adam Cuker, Kristen M. Sanfilippo, Et Al.

Open Access Publications

No abstract provided.

Impaired Eif5a Function Causes A Mendelian Disorder That Is Partially Rescued In Model Systems By Spermidine, Victor Faundes, Jorge L. Granadillo, Et Al.

Open Access Publications

No abstract provided.

Diffusion Histology Imaging Differentiates Distinct Pediatric Brain Tumor Histology, Zezhong Ye, Komal Srinivasa, Ashely Meyer, Peng Sun, Joshua Lin, Jeffrey D. Viox, Chunyu Song, Anthony T. Wu, Sheng-Kwei Song, Sonika Dahiya, Joshua B. Rubin

Open Access Publications

No abstract provided.

Targeting Primary And Metastatic Uveal Melanoma With A G Protein Inhibitor, Michael D. Onken, Carol M. Makepeace, Kevin M. Kaltenbronn, Joelle Choi, Leonel Hernandez-Aya, Katherine N. Weilbaecher, Kisha D. Piggott, P. Kumar Rao, Carla M. Yuede, Alethia J. Dixon, Patrick Osei-Owusu, John A. Cooper, Kendall J. Blumer

Open Access Publications

No abstract provided.

Brain Network Motifs Are Markers Of Loss And Recovery Of Consciousness, Catherine Duclos, Danielle Nadin, Yacine Mahdid, Vijay Tarnal, Paul Picton, Giancarlo Vanini, Goodarz Golmirzaie, Ellen Janke, Michael S. Avidan, Max B. Kelz, George A. Mashour, Stefanie Blain-Moraes

Open Access Publications

No abstract provided.

The Ideological Divide In Confidence In Science And Participation In Medical Research, Matthew Gabel, Jonathan Gooblar, Catherine M. Roe, John C. Morris

Open Access Publications

No abstract provided.

Targeting E-Selectin To Tackle Cancer Using Uproleselan, Barbara Muz, Anas Abdelghafer, Matea Markovic, Jessica Yavner, Anupama Melam, Noha Nabil Salama, Abdel Kareem Azab

Open Access Publications

E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins. E-selectin gained a new role since it was demonstrated to be involved in cancer cell trafficking, stem-like properties and therapy resistance. Therefore, being expressed in the tumor microenvironment, E-selectin can potentially be used to eradicate cancer. Uproleselan (also known as GMI-1271), a specific E-selectin antagonist, has been tested on leukemia, myeloma, pancreatic, colon and breast cancer cells, most of which involve the bone marrow as a primary or as a metastatic tumor site. This novel …

Glucosamine And Chondroitin Use In Relation To C-Reactive Protein Concentration: Results By Supplement Form, Formulation, And Dose, Elizabeth D. Kantor, Kelli O'Connell, Mengmeng Du, Chao Cao, Xuehong Zhang, Dong Hoon Lee, Yin Cao, Edward L. Giovannucci

Open Access Publications

No abstract provided.

Dynamic Patterns Of Yap1 Expression And Cellular Localization In The Developing And Injured Utricle, Vikrant Borse, Matthew Barton, Harry Arndt, Tejbeer Kaur, Mark E. Warchol

Open Access Publications

No abstract provided.

Single Cell Transcriptomic Analysis Of Human Pluripotent Stem Cell Chondrogenesis, Chia-Lung Wu, Amanda Dicks, Nancy Steward, Ruhang Tang, Dakota B. Katz, Yun-Rak Choi, Farshid Guilak

Open Access Publications

No abstract provided.

A Casz1–Nurd Complex Regulates Temporal Identity Transitions In Neural Progenitors, Pierre Mattar, Christine Jolicoeur, Thanh Dang, Sujay Shah, Brian S. Clark, Michel Cayouette

Open Access Publications

No abstract provided.

Pd‑L1 Expression In Angiomatoid Fbrous Histiocytoma, Joshua Byers, Hong Yin, Heather Rytting, Suzanna Logan, Mai He, Zhongxin Yu, Dehua Wang, Mikako Warren, Shamlal Mangray, Louis P. Dehner, Shengmei Zhou

Open Access Publications

No abstract provided.

Choroid Plexus Nkcc1 Mediates Cerebrospinal Fluid Clearance During Mouse Early Postnatal Development, Huixin Xu, Yong Zhang, Michael J. Holtzman, Et Al.

Open Access Publications

No abstract provided.

Cardiovascular Assessment Tool For Breast Cancer Survivors And Oncology Providers: Usability Study, Kathryn E Weaver, Heidi D Klepin, Brian J Wells, Emily V Dressler, Karen M Winkfield, Zanetta S Lamar, Tiffany P Avery, Nicholas M Pajewski, W Gregory Hundley, Aimee Johnson, Eleanor C Davidson, Marcelo Lopetegui, Randi E Foraker

Open Access Publications

BACKGROUND: Cardiovascular health is of increasing concern to breast cancer survivors and their health care providers, as many survivors are more likely to die from cardiovascular disease than cancer. Implementing clinical decision support tools to address cardiovascular risk factor awareness in the oncology setting may enhance survivors' attainment or maintenance of cardiovascular health.

OBJECTIVE: We sought to evaluate survivors' awareness of cardiovascular risk factors and examine the usability of a novel electronic health record enabled cardiovascular health tool from the perspective of both breast cancer survivors and oncology providers.

METHODS: Breast cancer survivors (n=49) recruited from a survivorship clinic interacted …

Disparities In Breastfeeding Among U.S. Black Mothers: Identification Of Mechanisms, Cara B. Safon, Timothy C. Heeren, Stephen M. Kerr, Daphney Clermont, Michael J. Corwin, Eve R. Colson, Rachel Y. Moon, Ann L. Kellams, Fern R. Hauck, Margaret G. Parker

Open Access Publications

No abstract provided.

Redox-Responsive Hyaluronic Acid-Based Nanogels For The Topical Delivery Of The Visual Chromophore To Retinal Photoreceptors, Amine M. Laradji, Alexander V. Kolesnikov, Bedia B. Karakoçak, Vladimir J. Kefalov, Nathan Ravi

Open Access Publications

No abstract provided.

A Priori Activation Of Apoptosis Pathways Of Tumor (Aaapt) Technology: Development Of Targeted Apoptosis Initiators For Cancer Treatment, Raghu S. Pandurangi, Marco Tomasetti, Sekar T. Verapazham, Ramasamy Paulmurugan, Cynthia Ma, Sandeep Rajput, Manjushree Anjanappa, Harikrishna Nakshatri

Open Access Publications

Cancer cells develop tactics to circumvent the interventions by desensitizing themselves to interventions. Amongst many, the principle routes of desensitization include a) activation of survival pathways (e.g. NF-kB, PARP) and b) downregulation of cell death pathways (e.g. CD95/CD95L). As a result, it requires high therapeutic dose to achieve tumor regression which, in turn damages normal cells through the collateral effects. Methods are needed to sensitize the low and non-responsive resistant tumor cells including cancer stem cells (CSCs) in order to evoke a better response from the current treatments. Current treatments including chemotherapy can induce cell death only in bulk cancer …

Endogenization Of A Prosimian Retrovirus During Lemur Evolution, Kathleen Apakupakul, Sharon L Deem, Rabia Maqsood, Peeti Sithiyopasakul, David Wang, Efrem S Lim

Open Access Publications

Studies of viruses that coevolved with lemurs provide an opportunity to understand the basal traits of primate viruses and provide an evolutionary context for host-virus interactions. Germline integration of endogenous retroviruses (ERVs) are fossil evidence of past infections. Hence, characterization of novel ERVs provides insight into the ancient precursors of extant viruses and the evolutionary history of their hosts. Here, we report the discovery of a novel endogenous retrovirus present in the genome of a lemur, Coquerel's sifaka (