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Haptoglobin Improves Shock, Lung Injury, And Survival In Canine Pneumonia, Kenneth E. Remy, Irene Cortés-Puch, Steven B. Solomon, Junfeng Sun, Benjamin M. Pockros, Jing Feng, Juan J. Lertora, Roy R. Hantgan, Xiaohua Liu, Andreas Perlegas, H. Shaw Warren, Mark T. Gladwin, Daniel B. Kim-Shapiro, Harvey G. Klein, Charles Natanson

Open Access Publications

During the last half-century, numerous antiinflammatory agents were tested in dozens of clinical trials and have proven ineffective for treating septic shock. The observation in multiple studies that cell-free hemoglobin (CFH) levels are elevated during clinical sepsis and that the degree of increase correlates with higher mortality suggests an alternative approach. Human haptoglobin binds CFH with high affinity and, therefore, can potentially reduce iron availability and oxidative activity. CFH levels are elevated over approximately 24-48 hours in our antibiotic-treated canine model of S. aureus pneumonia that simulates the cardiovascular abnormalities of human septic shock. In this 96-hour model, resuscitative treatments, …

Letting Go: Conceptualizing Intervention De-Implementation In Public Health And Social Service Settings, Virginia R Mckay, Alexandra B Morshed, Ross C Brownson, Enola K Proctor, Beth Prusaczyk

Open Access Publications

The discontinuation of interventions that should be stopped, or de-implementation, has emerged as a novel line of inquiry within dissemination and implementation science. As this area grows in human services research, like public health and social work, theory is needed to help guide scientific endeavors. Given the infancy of de-implementation, this conceptual narrative provides a definition and criteria for determining if an intervention should be de-implemented. We identify three criteria for identifying interventions appropriate for de-implementation: (a) interventions that are not effective or harmful, (b) interventions that are not the most effective or efficient to provide, and (c) interventions that …

Bezlotoxumab For Prevention Of Recurrent Clostridium Difficile Infection In Patients At Increased Risk For Recurrence, Dale N. Gerding, Ciaran P. Kelly, Galia Rahav, Christine Lee, Erik R. Dubberke, Princy N. Kumar, Bruce Yacyshyn, Dina Kao, Karen Eves, Misoo C. Ellison, Mary E. Hanson, Dalya Guris, Mary Beth Dorr

Open Access Publications

Background: Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B indicated to prevent C. difficile infection (CDI) recurrence (rCDI) in adults at high risk for rCDI. This post hoc analysis of pooled monocolonal antibodies for C.difficile therapy (MODIFY) I/II data assessed bezlotoxumab efficacy in participants with characteristics associated with increased risk for rCDI.

Methods: The analysis population was the modified intent-to-treat population who received bezlotoxumab or placebo (n = 1554) by risk factors for rCDI that were prespecified in the statistical analysis plan: age ≥65 years, history of CDI, compromised immunity, severe CDI, and ribotype 027/078/244. The proportion …

International Volunteerism And Urethral Stricture Disease: A Review, Jason K. Frankel, Gregory P. Murphy

Open Access Publications

Global health is an ever-expanding area of interest for many healthcare workers around the world. In recent years, it has become apparent that much of the global disease burden is surgical. Urologic disease is no exception-many international organizations send volunteers around the world to support Urologic services in countries that lack capacity and resources. Urethral stricture represents a unique opportunity for specialized surgical management that vastly improves long term morbidity. Here we review the prevalence, etiology, and management of urethral stricture from a global perspective while highlighting impact of international urologic volunteer efforts.

Association Of Inferior Vena Cava Filter Placement For Venous Thromboembolic Disease And A Contraindication To Anticoagulation With 30-Day Mortality, Tyson E. Turner, Mohammed J. Saeed, Eric Novak, David L. Brown

Open Access Publications

Importance: Despite the absence of data from randomized clinical trials, professional societies recommend inferior vena cava (IVC) filters for patients with venous thromboembolic disease (VTE) and a contraindication to anticoagulation therapy. Prior observational studies of IVC filters have suggested a mortality benefit associated with IVC filter insertion but have often failed to adjust for immortal time bias, which is the time before IVC filter insertion, during which death can only occur in the control group.

Objective: To determine the association of IVC filter placement with 30-day mortality after adjustment for immortal time bias.

Design, Setting, and Participants: This comparative effectiveness, …

Decreasing Recurrent Bowel Obstructions, Improving Quality Of Life With Physiotherapy: Controlled Study, Amanda D Rice, Kimberley Patterson, Evette D Reed, Belinda F Wurn, Kristen Robles, Bernhard Klingenberg, Leonard B Weinstock, Janey S. A. Pratt, C. Richard King Iii, Lawrence J Wurn

Open Access Publications

AIM: To compare (1) quality of life and (2) rate of recurrent small bowel obstructions (SBO) for patients treated with novel manual physiotherapy

METHODS: One hundred and three subjects (age 19-89) with a history of recurrent adhesive SBO were treated with a manual physiotherapy called the Clear Passage Approach (CPA) which focused on decreasing adhesive crosslinking in abdominopelvic viscera. Pre- and post-therapy data measured recurring obstructions and quality of life, using a validated test sent 90 d after therapy. Results were compared to 136 untreated control subjects who underwent the same measurements for subjects who did not receive any therapy, …

A Systematic, Intensive Statistical Investigation Of Data From The Comprehensive Analysis Of Reported Drugs (Card) For Compliance And Illicit Opioid Abstinence In Substance Addiction Treatment With Buprenorphine/Naloxone, Kenneth Blum, David Han, Edward J Modestino, Scott Saunders, A Kennison Roy 3rd, W Jacobs, Darryl S Inaba, David Baron, Marlene Oscar-Berman, Mary Hauser, Rajendra D Badgaiyan, David E Smith, John Femino, Mark S Gold

Open Access Publications

BACKGROUND: Buprenorphine and naloxone (bup/nal), a combination partial mu receptor agonist and low-dose delta mu antagonist, is presently recommended and used to treat opioid-use disorder. However, a literature review revealed a paucity of research involving data from urine drug tests that looked at compliance and abstinence in one sample.

METHOD: Statistical analysis of data from the Comprehensive Analysis of Reported Drugs (CARD) was used to assess compliance and abstinence during treatment in a large cohort of bup/nal patients attending chemical-dependency programs from eastern USA in 2010 and 2011.

RESULTS: Part 1: Bup/nal was present in 93.4% of first (n = …

Diagnostic Performance Of Multiplex Nucleic Acid Testing Of Bronchoalveolar Lavage And Bronchial Wash Specimens For Respiratory Viral Pathogens, Satish Munigala, Carey-Ann D. Burnham, Neil W. Anderson, Stephen Y. Liang, Steven J. Lawrence, David K. Warren

Open Access Publications

No abstract provided.

Mycobacterium Tuberculosis Type Vii Secretion System Effectors Differentially Impact The Escrt Endomembrane Damage Response, Ekansh Mittal, Michael L. Skowyra, Grace Uwase, Emir Tinaztepe, Alka Mehra, Stefan Köster, Phyllis I. Hanson, Jennifer A. Philips

Open Access Publications

No abstract provided.

Synthesis And Evaluation Of Troponoids As A New Class Of Antibiotics, Feng Cao, Cari Orth, Maureen J. Donlin, Patrick Adegboyega, Marvin J. Meyers, Ryan P. Murelli, Mohamed Elagawany, Bahaa Elgendy, John E. Tavis

Open Access Publications

No abstract provided.

Geogenomic Segregation And Temporal Trends Of Human Pathogenic Escherichia Coli O157:H7, Washington, Usa, 2005-2014, Gillian A. M. Tarr, Smriti Shringi, Amanda I. Phipps, Thomas E. Besser, Jonathan Mayer, Hanna N. Oltean, Jon Wakefield, Phillip I. Tarr, Peter Rabinowitz

Open Access Publications

No abstract provided.

An Assessment Of Inappropriate Antibiotic Use And Guideline Adherence For Uncomplicated Urinary Tract Infections, Michael J. Durkin, Matthew Keller, Anne M. Butler, Jennie H. Kwon, Erik R. Dubberke, Aaron C. Miller, Phillip M. Polgreen, Margaret A. Olsen

Open Access Publications

No abstract provided.

A Knock-In Tristetraprolin (Ttp) Zinc Finger Point Mutation In Mice: Comparison With Complete Ttp Deficiency, Wi S. Lai, Deborah J. Stumpo, Lianqun Qiu, Roberta Faccio, Perry J. Blackshear

Open Access Publications

No abstract provided.

Importance Of Site Of Infection And Antibiotic Selection In The Treatment Of Carbapenem-Resistant Pseudomonas Aeruginosa Sepsis, Nicholas S. Britt, David J. Ritchie, Marin H. Kollef, Carey-Ann D. Burnham, Michael J. Durkin, Nicholas B. Hampton, Scott T. Micek

Open Access Publications

No abstract provided.

Enterovirus D68 Surveillance, St. Louis, Missouri, Usa, 2016, Mythili Srinivasan, Angela Niesen, Gregory A. Storch

Open Access Publications

No abstract provided.

The Role Of Bpifa1 In Upper Airway Microbial Infections And Correlated Diseases, Yung-An Tsou, Min-Che Tung, Katherine A. Alexander, Wen-Dien Chang, Ming-Hsui Tsai, Hsiao-Ling Chen, Chuan-Mu Chen

Open Access Publications

No abstract provided.

Infectious Diseases Consultation Reduces 30-Day And 1-Year All-Cause Mortality For Multidrug-Resistant Organism Infections, Jason P. Burnham, Margaret A. Olsen, Dustin Stwalley, Jennie H. Kwon, Hilary M. Babcock, Marin H. Koller

Open Access Publications

No abstract provided.

Diagnostic Interpretation Guidance For Pediatric Enteric Pathogens: A Modified Delphi Consensus Process, Carey-Ann D. Burnham, Phillip I. Tarr

Open Access Publications

No abstract provided.

Epidemiology, Clinical Characteristics, And Antimicrobial Susceptibility Profiles Of Human Clinical Isolates Of Staphylococcus Intermedius Group, Melanie L. Yarbrough, William Lainhart, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

Functional Role Of The Type 1 Pilus Rod Structure In Mediating Host-Pathogen Interactions, Caitlin N. Spaulding, Henry Louis Schreiber Iv, Weili Zheng, Karen W. Dodson, Jennie E. Hazen, Matt S. Conover, Fengbin Wang, Pontus Svenmarker, Areli Luna-Rico, Olivera Francetic, Magnus Andersson, Scott Hultgren, Edward H. Egelman

Open Access Publications

No abstract provided.

Readmissions With Multidrug-Resistant Infection In Patients With Prior Multidrug Resistant Infection, Jason P. Burnham, Jennie H. Kwon, Margaret A. Olsen, Hilary M. Babcock, Marin H. Kollef

Open Access Publications

No abstract provided.

An Accord Of Nuclear Receptor Expression In M. Tuberculosis Infected Macrophages And Dendritic Cells, Ankita Saini, Sahil Mahajan, Nancy Ahuja, Ella Bhagyaraj, Rashi Kalra, Ashok Kumar Janmeja, Pawan Gupta

Open Access Publications

No abstract provided.

The Brief Case: Staphylococcus Intermedius Group—Look What The Dog Dragged In, William Lainhart, Melanie L. Yarbrough, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

Udp-Glucuronic Acid Transport Is Required For Virulence Of Cryptococcus Neoformans, Lucy X. Li, Carsten Rautengarten, Joshua L. Heazlewood, Tamara L. Doering

Open Access Publications

No abstract provided.

Stem Cell-Derived Models Of Viral Infections In The Gastrointestinal Tract, Wyatt E. Lanik, Madison A. Mara, Belgacem Mihi, Carolyn B. Coyne, Misty Good

Open Access Publications

No abstract provided.

Structure-Based Discovery Of Glycomimetic Fmlh Ligands As Inhibitors Of Bacterial Adhesion During Urinary Tract Infection, Vasilios Kalas, Michael E. Hibbing, Amarendar Reddy Maddirala, Ryan Chugani, Jerome S. Pinkner, Laurel K. Mydock-Mcgrane, Matt S. Conover, James W. Janetka, Scott J. Hultgren

Open Access Publications

No abstract provided.

Project Help: A Study Protocol To Pilot Test A Shared Decision-Making Tool About Treatment Options For Patients With Hepatitis C And Chronic Kidney Disease, M. C. Politi, N. George, T. Li, K. M. Korenblat, K. J. Fowler, C. Ho, A. Liapakis, D. Roth, J. Yee

Open Access Publications

No abstract provided.

Outpatient Antibiotic Prescription Trends In The United States: A National Cohort Study, Michael J. Durkin, S. Reza Jafarzadeh, Kevin Hsueh, Ya Haddy Sallah, Kiraat D. Munshi, Rochelle R. Henderson, Victoria J. Fraser

Open Access Publications

No abstract provided.

Heartland Virus And Hemophagocytic Lymphohistiocytosis In Immunocompromised Patient, Missouri, Usa, Abigail L. Carlson, Daniel M. Pastula, Amy J. Lambert, J. Erin Staples, Atis Muehlenbachs, George Turabelidze, Charles S. Eby, Jesse Keller, Brian Hess, Richard S. Buller, Gregory A. Storch, Kathleen Byrnes, Louis Dehner, Nigar Kirmani, F. Matthew Kuhlmann

Open Access Publications

No abstract provided.

Natural History Of Plasmodium Odocoilei Malaria Infection In Farmed White-Tailed Deer, Ann M. Guggisberg, Katherine A. Sayler, Samantha M. Wisely, Audrey R. Odom John

Open Access Publications

No abstract provided.