Digital Commons Network^™

Incidence Of Acute Kidney Injury In Critically Ill Patients Receiving Vancomycin With Concomitant Piperacillin-Tazobactam, Cefepime, Or Meropenem, Adam M. Blevins, Jennifer N. Lashinsky, Craig Mccammon, Marin Kollef, Scott Micek, Paul Juang

Open Access Publications

No abstract provided.

The Natural Cytotoxicity Receptors In Health And Disease, Alexander David Barrow, Claudia Jane Martin, Marco Colonna

Open Access Publications

No abstract provided.

Pigment Visibility On Rectal Swabs Used To Detect Enteropathogens: A Prospective Cohort Study, Jianling Xie, Gillian A.M. Tarr, Samina Ali, Linda Chui, Xiao-Li Pang, Bonita E. Lee, Otto G. Vanderkooi, Phillip I. Tarr, Ran Zhuo, Brendon Parsons, Byron M. Berenger, Kelly Kim, Stephen B. Freedman, Alberta Provincial Pediatric Enteric Infection Team (Appetite) And Pediatric Emergency Research Canada (Perc)

Open Access Publications

No abstract provided.

Culture Of Rectal Swab Specimens For Enteric Bacterial Pathogens Decreases Time To Test Result While Preserving Assay Sensitivity Compared To Bulk Fecal Specimens, Sophonie Jean, Melanie L. Yarbrough, Neil W. Anderson, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

Effect Of Changing Urine Testing Orderables And Clinician Order Sets On Inpatient Urine Culture Testing: Analysis From A Large Academic Medical Center, Satish Munigala, Rebecca Rojek, Helen Wood, Melanie L. Yarbrough, Ronald R. Jackups, Carey-Ann D. Burnham, David K. Warren

Open Access Publications

No abstract provided.

Methods Of Estimating Vancomycin Use In An Inpatient Setting: Days Of Therapy Versus Therapeutic Drug Monitoring–Based Exposure Days, Shutaro Murakami, Junko Hiroi, Yasuharu Tokuda, Ed Casabar, Hitoshi Honda

Open Access Publications

No abstract provided.

Going Beyond The Individual: How State-Level Characteristics Relate To Hpv Vaccine Rates In The United States, Melissa Franco, Stephanie Mazzucca, Margaret Padek, Ross C. Brownson

Open Access Publications

No abstract provided.

Combining Procalcitonin With The Qsofa And Sepsis Mortality Prediction, Hua Yu, Lu Nie, Aibo Liu, Kuihai Wu, Yenh-Chen Hsein, Debra W. Yen, Meng-Tse G. Lee, Chien-Chang Lee

Open Access Publications

No abstract provided.

2019 Update Of The Wses Guidelines For Management Of Clostridioides (Clostridium) Difficile Infection In Surgical Patients, John E. Mazuski, Et Al

Open Access Publications

No abstract provided.

Identifcation Of Small Molecule Enzyme Inhibitors As Broad-Spectrum Anthelmintics, Rahul Tyagi, Mostafa A. Elfawal, Scott A. Wildman, Jon Helander, Christina A. Bulman, Judy Sakanari, Bruce A. Rosa, Paul J. Brindley, James W. Janetka, Raffi V. Aroian, Makedonka Mitreva

Open Access Publications

No abstract provided.

Phages And Human Health: More Than Idle Hitchhikers, Dylan Lawrence, Megan T. Baldridge, Scott A. Handley

Open Access Publications

No abstract provided.

Outcomes Of Haploidentical Vs Matched Sibling Transplantation For Acute Myeloid Leukemia In First Complete Remission, Keith Stockerl-Goldstein, Et Al.

Open Access Publications

No abstract provided.

Bioresorbable Optical Sensor Systems For Monitoring Of Intracranial Pressure And Temperature, Jiho Shin, Zhonghe Liu, Wubin Bai, Yonghao Liu, Ying Yang, Yeguang Xue, Irawati Kandela, Maryam Pezhouh, Matthew R. Macewan, Yonggang Huang, Wilson Z. Ray, Weidong Zhou, John A. Rogers

Open Access Publications

No abstract provided.

Insights Into The Microbiome Of Breast Implants And Periprosthetic Tissue In Breast Implant-Associated Anaplastic Large Cell Lymphoma, Jennifer N. Walker, Blake M. Hanson, Chloe L. Pinkner, Shelby R. Simar, Jerome S. Pinkner, Rajiv Parikh, Mark W. Clemens, Scott J. Hultgren, Terence M. Myckatyn

Open Access Publications

No abstract provided.

A National Survey Of Testing And Management Of Asymptomatic Carriage Of C. Difficile, Preeta K. Kutty, Susan E. Beekmann, Ronda L. Sinkowitz-Cochran, Erik R. Dubberke, David T. Kuhar, L. C. Mcdonald, Philip M. Polgreen

Open Access Publications

No abstract provided.

Implementation Science For The Bedside, Elvin H. Geng

Open Access Publications

No abstract provided.

(P)Ppgpp And Cody Promote Enterococcus Faecalis Virulence In A Murine Model Of Catheter-Associated Urinary Tract Infection, C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos

Open Access Publications

No abstract provided.

Genotypic And Phenotypic Characterization Of Antimicrobial Resistance In Neisseria Gonorrhoeae: A Cross-Sectional Study Of Isolates Recovered From Routine Urine Cultures In A High-Incidence Setting, Adam L. Bailey, Robert F. Potter, Meghan A. Wallace, Caitlin Johnson, Gautam Dantas, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

Clinical Impact Of An Antimicrobial Stewardship Program On High-Risk Pediatric Patients, Jennifer L. Goldman, Jason G. Newland, Michael Prince, Diana Yu, Brian R. Lee

Open Access Publications

No abstract provided.

Inhaled Gm-Csf In Neonatal Mice Provides Durable Protection Against Bacterial Pneumonia, Elizabeth M. Todd, Rashmi Ramani, Taylor P. Szasz, S. Celeste Morley

Open Access Publications

No abstract provided.

Allogeneic Transplantation In Elderly Patients ≥65 Years With Non-Hodgkin Lymphoma: A Time-Trend Analysis, Nirav N. Shah, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

Open Access Publications

No abstract provided.

Reported Variability In Healthcare Facility Policies Regarding Healthcare Personnel Working While Experiencing Influenza-Like Illnesses: An Emerging Infections Network Survey, Hilary M Babcock, Susan E Beekmann, Satish K Pillai, Scott Santibanez, Leslie Lee, David T Kuhar, Angela P Campbell, Anita Patel, Philip M Polgreen

Open Access Publications

BACKGROUND: Presenteeism, or working while ill, by healthcare personnel (HCP) experiencing influenza-like illness (ILI) puts patients and coworkers at risk. However, hospital policies and practices may not consistently facilitate HCP staying home when ill.

OBJECTIVE AND METHODS: We conducted a mixed-methods survey in March 2018 of Emerging Infections Network infectious diseases physicians, describing institutional experiences with and policies for HCP working with ILI.

RESULTS: Of 715 physicians, 367 (51%) responded. Of 367, 135 (37%) were unaware of institutional policies. Of the remaining 232 respondents, 206 (89%) reported institutional policies regarding work restrictions for HCP with influenza or ILI, but only …

A Broad Spectrum Protein Glycosylation System Influences Type Ii Protein Secretion And Associated Phenotypes In Vibrio Cholerae, Dina Vorkapic, Mario F Feldman, Et Al

Open Access Publications

Protein secretion plays a crucial role for bacterial pathogens, exemplified by facultative human-pathogen

Antibiotic Stewardship Teams And Clostridioides Difficile Practices In United States Hospitals: A National Survey In The Joint Commission Antibiotic Stewardship Standard Era, Valerie M Vaughn, M Todd Greene, David Ratz, Karen E Fowler, Sarah L Krein, Scott A Flanders, Erik R Dubberke, Sanjay Saint, Payal K Patel

Open Access Publications

OBJECTIVE: Clostridioides difficile infection (CDI) can be prevented through infection prevention practices and antibiotic stewardship. Diagnostic stewardship (ie, strategies to improve use of microbiological testing) can also improve antibiotic use. However, little is known about the use of such practices in US hospitals, especially after multidisciplinary stewardship programs became a requirement for US hospital accreditation in 2017. Thus, we surveyed US hospitals to assess antibiotic stewardship program composition, practices related to CDI, and diagnostic stewardship.

METHODS: Surveys were mailed to infection preventionists at 900 randomly sampled US hospitals between May and October 2017. Hospitals were surveyed on antibiotic stewardship programs; …

Top 10 Research Priorities In Spatial Lifecourse Epidemiology, Peng Jia, Ross C. Brownson, Et Al.

Open Access Publications

No abstract provided.

Genomic Characterization Of Antibiotic Resistant Escherichia Coli Isolated From Domestic Chickens In Pakistan, Muhammad Rafique, Robert F Potter, Aura Ferreiro, Meghan A Wallace, Abdul Rahim, Akbar Ali Malik, Naila Siddique, Muhammad Athar Abbas, Alaric W D'Souza, Carey-Ann D Burnham, Naeem Ali, Gautam Dantas

Open Access Publications

Poultry husbandry is important for the economic health of Pakistan, but the Pakistani poultry industry is negatively impacted by infections from

The Interplay Between Viral-Derived Mirnas And Host Immunity During Infection, Richa Mishra, Ashish Kumar, Harshad Ingle, Himanshu Kumar

Open Access Publications

MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection. In the last decade, multiple DNA and RNA viruses have been shown to produce miRNAs known as viral miRNAs (v-miRNAs) so as to evade the host immune response. In this review, we highlight the origin and biogenesis of viral miRNAs during the viral lifecycle. We also explore the role of viral miRNAs in immune evasion and hence in maintaining chronic infection and disease. Finally, we offer insights into …

Visualization Of Positive And Negative Sense Viral Rna For Probing The Mechanism Of Direct-Acting Antivirals Against Hepatitis C Virus, Dandan Liu, Philip R Tedbury, Shuiyun Lan, Andrew D Huber, Maritza N Puray-Chavez, Juan Ji, Eleftherios Michailidis, Mohsan Saeed, Tanyaradzwa P Ndongwe, Leda C Bassit, Raymond F Schinazi, Robert Ralston, Charles M Rice, Stefan G Sarafianos

Open Access Publications

RNA viruses are highly successful pathogens and are the causative agents for many important diseases. To fully understand the replication of these viruses it is necessary to address the roles of both positive-strand RNA ((+)RNA) and negative-strand RNA ((-)RNA), and their interplay with viral and host proteins. Here we used branched DNA (bDNA) fluorescence in situ hybridization (FISH) to stain both the abundant (+)RNA and the far less abundant (-)RNA in both hepatitis C virus (HCV)- and Zika virus-infected cells, and combined these analyses with visualization of viral proteins through confocal imaging. We were able to phenotypically examine HCV-infected cells …

A Herpesvirus Encoded Qa-1 Mimic Inhibits Natural Killer Cell Cytotoxicity Through Cd94/Nkg2a Receptor Engagement, Xiaoli Wang, Sytse J. Piersma, Christopher A. Nelson, Ya-Nan Dai, Ted Christensen, Eric Lazear, Liping Yang, Marjolein Sluijter, Thorbald Van Hall, Ted H. Hansen, Wayne M. Yokoyama, Daved H. Fremont

Open Access Publications

A recurrent theme in viral immune evasion is the sabotage of MHC-I antigen presentation, which brings virus the concomitant issue of 'missing-self' recognition by NK cells that use inhibitory receptors to detect surface MHC-I proteins. Here, we report that rodent herpesvirus Peru (RHVP) encodes a Qa-1 like protein (pQa-1) via RNA splicing to counteract NK activation. While pQa-1 surface expression is stabilized by the same canonical peptides presented by murine Qa-1, pQa-1 is GPI-anchored and resistant to the activity of RHVP pK3, a ubiquitin ligase that targets MHC-I for degradation. pQa-1 tetramer staining indicates that it recognizes CD94/NKG2A receptors. Consistently, …