Digital Commons Network^™

Change In Age At Diagnosis Of Oropharyngeal Cancer In The United States, 1975-2016, Brittany J Cline, Matthew C Simpson, Matthew Gropler, Aleksandr R Bukatko, Eric Adjei Boakye, Kahee A Mohammed, Nosayaba Osazuwa-Peters

Open Access Publications

The emergence of the human papillomavirus (HPV) as the primary etiology of oropharyngeal cancer has changed head and neck cancer (HNC) epidemiology. This study described change in the age at diagnosis of oropharyngeal and non-oropharyngeal HNC in the United States in the last four decades. Using a retrospective cohort analysis, the Surveillance, Epidemiology, and End Results dataset from 1975 to 2016 was queried for eligible adult cases of HNC, grouped as oropharyngeal (

A Smartphone-Based Technique To Detect Dynamic User Preferences For Tailoring Behavioral Interventions: Observational Utility Study Of Ecological Daily Needs Assessment, Ginger E Nicol, Amanda R Ricchio, Christopher L Metts, Michael D Yingling, Alex T Ramsey, Julia A Schweiger, J Philip Miller, Eric J Lenze

Open Access Publications

BACKGROUND: Mobile health apps are promising vehicles for delivering scalable health behavior change interventions to populations that are otherwise difficult to reach and engage, such as young adults with psychiatric conditions. To improve uptake and sustain consumer engagement, mobile health interventions need to be responsive to individuals' needs and preferences, which may change over time. We previously created an ecological daily needs assessment to capture microprocesses influencing user needs and preferences for mobile health treatment adaptation.

OBJECTIVE: The objective of our study was to test the utility of a needs assessment anchored within a mobile app to capture individualized, contextually …

Depression And Nicotine Withdrawal Associations With Combustible And Electronic Cigarette Use, Michele L Pergadia, John W Newcomer, David G Gilbert

Open Access Publications

Depression is a risk factor for nicotine use and withdrawal. Population level epidemiologic studies that include users of either combustible or electronic cigarette (NICUSER) could inform interventions to reduce nicotine dependence in vulnerable populations. The current study examined the relationship between depression diagnosis (DEPDX), NICUSER, and lifetime rates of DSM-V nicotine withdrawal (NW) symptoms in a nationally representative sample of US adults (

Pd-L1 Blockade In Combination With Inhibition Of Mapk Oncogenic Signaling In Patients With Advanced Melanoma, Antoni Ribas, Alain Algazi, Paolo A. Ascierto, Marcus O. Butler, Sunandana Chandra, Michael Gordon, Leonel Hernandez-Aya, Donald Lawrence, Jose Lutzky, Wilson H. Miller Jr., Katie M. Campbell, Bruno Delafont, Shannon Marshall, Nancy Mueller, Caroline Robert

Open Access Publications

No abstract provided.

Histone H3.3 Beyond Cancer: Germline Mutations In Histone 3 Family 3a And 3b Cause A Previously Unidentified Neurodegenerative Disorder In 46 Patients, Laura Bryant, Marcia C Willing, Linda Manwaring, Et Al

Open Access Publications

Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyze 46 patients bearing de novo germline mutations in histone 3 family 3A (

A Matricellular Protein Fibulin-4 Is Essential For The Activation Of Lysyl Oxidase, Kazuo Noda, Kaori Kitagawa, Takao Miki, Masahito Horiguchi, Tomoya O Akama, Takako Taniguchi, Hisaaki Taniguchi, Kazuaki Takahashi, Yasumitsu Ogra, Robert P Mecham, Masahiko Terajima, Mitsuo Yamauchi, Tomoyuki Nakamura

Open Access Publications

Fibulin-4 is a matricellular protein required for extracellular matrix (ECM) assembly. Mice deficient in fibulin-4 (

Adolescent Alcohol, Nuts, And Fiber: Combined Effects On Benign Breast Disease Risk In Young Women, Catherine S. Berkey, Rulla M. Tamimi, Walter C. Willett, Bernard Rosner, Martha Hickey, Adetunji T. Toriola, A. Lindsay Frazier, Graham A. Colditz

Open Access Publications

No abstract provided.

Natural Bladder Flling Alters Resting Brain Function At Multiple Spatial Scales: A Proof‑Of‑Concept Mapp Network Neuroimaging Study, Ishtiaq Mawla, Henry Lai, Gerald Andriole, Et Al.

Open Access Publications

No abstract provided.

Comparing Cortical Signatures Of Atrophy Between Late-Onset And Autosomal Dominant Alzheimer Disease, Aylin Dincer, Brian A Gordon, Sarah J Keefe, Shaney Flores, Nicole S Mckay, Angela M Paulick, Rebecca L Feldman, Russ C Hornbeck, Beau M Ances, Nelly Joseph-Mathurin, Celeste M Karch, Eric M Mcdade, Richard J Perrin, Cyrus Raji, Qing Wang, Chengjie Xiong, John C Morris, Randall J Bateman, Tammie L S Benzinger, Et Al

Open Access Publications

Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since late-onset Alzheimer disease (LOAD) participants tend to have age-related comorbidities, the younger-onset age in autosomal dominant AD (ADAD) may provide a more idealized model of cortical thinning in AD. To test this, the goals of this study were to compare the degree of overlap between the ADAD and LOAD cortical thinning maps and to evaluate the ability of the ADAD cortical signature regions to predict early pathological changes …

Pathophysiological Consequences Of Katp Channel Overactivity And Pharmacological Response To Glibenclamide In Skeletal Muscle Of A Murine Model Of Cantù Syndrome, Rosa Scala, Fatima Maqoud, Nicola Zizzo, Antonietta Mele, Giulia Maria Camerino, Francesco Alfredo Zito, Girolamo Ranieri, Conor Mcclenaghan, Theresa M Harter, Colin G Nichols, Domenico Tricarico

Open Access Publications

Cantù syndrome (CS) arises from mutations in

Robot Assisted Mri-Guided Litt Of The Anterior, Lateral, And Medial Temporal Lobe For Temporal Lobe Epilepsy, Kunal Gupta, Adam S Dickey, Ranliang Hu, Edward Faught, Jon T Willie

Open Access Publications

Robotic systems have fundamentally altered the landscape of functional neurosurgery. These allow automated stereotaxy with high accuracy and reliability, and are rapidly becoming a mainstay in stereotactic surgeries such as deep brain stimulation (DBS), stereoelectroencephalography (SEEG), and stereotactic laser ablation/MRI guided laser interstitial thermal therapy (MRgLITT). Robotic systems have been effectively applied to create a minimally invasive approach for diagnostics and therapeutics in the treatment of epilepsy, utilizing robots for expeditious and accurate stereotaxy for SEEG and MRgLITT. MRgLITT has been shown to approach open surgical techniques in efficacy of seizure control while minimizing collateral injury. We describe the use …

Exploring Differences In The Role Of Hospitalization On Weight Gain Based On Treatment Type From Randomized Clinical Trials For Adolescent Anorexia Nervosa, Nandini Datta, Brittany E Matheson, Daniel Le Grange, Harry A Brandt, Blake Woodside, Katherine A Halmi, Denise E Wilfley, James D Lock

Open Access Publications

No abstract provided.

Utilization Of The Sharing Antimicrobial Reports For Pediatric Stewardship (Sharps) Collaborative Electronic Mailing List (Listserv) By Healthcare Professionals, Christopher C Mcpherson, Zachary A Vesoulis, Talene A Metjian, Mirela Grabic, Summer Reyes, Sydney Reyes, Christina Krucylak, Cindy Terrill, Jason G Newland

Open Access Publications

Optimizing pediatric antimicrobial stewardship is challenging. In this retrospective study, we evaluated 515 original e-mails to 482 members of the Sharing Antimicrobial Reports for Pediatric Stewardship (SHARPS) Collaborative electronic mailing list ([email protected]). The plurality of threads discussed clinical practice guidelines, and pharmacists were most likely to initiate and respond. Representation was geographically diverse within and outside the United States.

Clinical Implications Of Restrictions In Criteria For Defining Surgical Site Infections After Mastectomy, Antoinette A A Bediako-Bowan, David K Warren, Katelin B Nickel, Victoria J Fraser, Margaret A Olsen

Open Access Publications

More than 50% of women with clinically apparent infection after mastectomy did not meet the 2020 National Healthcare Safety Network (NHSN) definition for surgical site infection (SSI). Implant loss was similar whether the 2020 NHSN SSI definition was met or not, suggesting equivalent adverse outcomes regardless of restriction to the surveillance definition.

Pediatric Research Priorities In Healthcare-Associated Infections And Antimicrobial Stewardship, Susan E Coffin, Stephanie Fritz, Jason Newland, Et Al

Open Access Publications

OBJECTIVE: To develop a pediatric research agenda focused on pediatric healthcare-associated infections and antimicrobial stewardship topics that will yield the highest impact on child health.

PARTICIPANTS: The study included 26 geographically diverse adult and pediatric infectious diseases clinicians with expertise in healthcare-associated infection prevention and/or antimicrobial stewardship (topic identification and ranking of priorities), as well as members of the Division of Healthcare Quality and Promotion at the Centers for Disease Control and Prevention (topic identification).

METHODS: Using a modified Delphi approach, expert recommendations were generated through an iterative process for identifying pediatric research priorities in healthcare associated infection prevention and …

Deep Brain Stimulation Of The Subthalamic Nucleus Modulates Reward-Related Behavior: A Systematic Review, Yvan M Vachez, Meaghan C Creed

Open Access Publications

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an effective treatment for the motor symptoms of movement disorders including Parkinson's Disease (PD). Despite its therapeutic benefits, STN-DBS has been associated with adverse effects on mood and cognition. Specifically, apathy, which is defined as a loss of motivation, has been reported to emerge or to worsen following STN-DBS. However, it is often challenging to disentangle the effects of STN-DBS

Documenting Social Media Engagement As Scholarship: A New Model For Assessing Academic Accomplishment For The Health Professions, Kimberly D Acquaviva, Rakhee K Bhayani, Et Al

Open Access Publications

BACKGROUND: The traditional model of promotion and tenure in the health professions relies heavily on formal scholarship through teaching, research, and service. Institutions consider how much weight to give activities in each of these areas and determine a threshold for advancement. With the emergence of social media, scholars can engage wider audiences in creative ways and have a broader impact. Conventional metrics like the h-index do not account for social media impact. Social media engagement is poorly represented in most curricula vitae (CV) and therefore is undervalued in promotion and tenure reviews.

OBJECTIVE: The objective was to develop crowdsourced guidelines …

Fetal Cortical Plate Segmentation Using Fully Convolutional Networks With Multiple Plane Aggregation, Jinwoo Hong, Hyuk Jin Yun, Gilsoon Park, Seonggyu Kim, Cynthia T Laurentys, Leticia C Siqueira, Tomo Tarui, Caitlin K Rollins, Cynthia M Ortinau, P Ellen Grant, Jong-Min Lee, Kiho Im

Open Access Publications

Fetal magnetic resonance imaging (MRI) has the potential to advance our understanding of human brain development by providing quantitative information of cortical plate (CP) development

Comparison Of Smartphone Photography, Single-Lens Reflex Photography, And Field-Grading For Trachoma, John M Nesemann, Michael I Seider, Blake M Snyder, Robi N Maamari, Daniel A Fletcher, Berhan A Haile, Zerihun Tadesse, Nicole E Varnado, Sun Y Cotter, Elizabeth Kelly Callahan, Paul M Emerson, Todd P Margolis, Thomas M Lietman, Jeremy D Keenan

Open Access Publications

Conjunctival examination for trachomatous inflammation-follicular (TF) guides public health decisions for trachoma. Smartphone cameras may allow remote conjunctival grading, but previous studies have found low sensitivity. A random sample of 412 children aged 1-9 years received an in-person conjunctival examination and then had conjunctival photographs taken with 1) a single-lens reflex (SLR) camera and 2) a smartphone coupled to a 3D-printed magnifying attachment. Three masked graders assessed the conjunctival photographs for TF. Latent class analysis was used to determine the sensitivity and specificity of each grading method for TF. Single-lens reflex photo-grading was 95.0% sensitive and 93.6% specific, and smartphone …

Biomarkers May Predict Unfavorable Neurological Outcome After Mild Traumatic Brain Injury, Lawrence M. Lewis, Linda Papa, Jeffrey J. Bazarian, Art Weber, Rob Howard, Robert D. Welch

Open Access Publications

No abstract provided.

Differences In Electronic Personal Health Information Tool Use Between Rural And Urban Cancer Patients In The United States: Secondary Data Analysis, Alexandra Greenberg-Worisek, Liaa Ferede, Joyce Balls-Berry, Ian Marigi, Emily Valentin Mendez, Numra Bajwa, Melody Ouk, Minerva Orellana, Felicity Enders

Open Access Publications

BACKGROUND: Studies have previously shown that rural cancer patients are diagnosed at later stages of disease. This delay is felt throughout treatment and follow-up, reflected in the fact that rural patients often have poorer clinical outcomes compared with their urban counterparts.

OBJECTIVE: Few studies have explored whether there is a difference in cancer patients' current use of health information technology tools by residential location.

METHODS: Data from 7 cycles of the Health Information National Trends Survey (HINTS, 2003-2017) were merged and analyzed to examine whether differences exist in managing electronic personal health information (ePHI) and emailing health care providers among …

From Stigma To Validation: A Qualitative Assessment Of A Novel National Program To Improve Retention Of Physician-Scientists With Caregiving Responsibilities, Rochelle D. Jones, Victoria J. Fraser, Et Al.

Open Access Publications

No abstract provided.

Endothelial Cell Cd36 Deficiency Prevents Normal Angiogenesis And Vascular Repair, Lara Bou Khzam, Ni-Huiping Son, Adam E Mullick, Nada A Abumrad, Ira J Goldberg

Open Access Publications

Endothelial cells (ECs) maintain vascular integrity and mediate vascular repair and angiogenesis, by which new blood vessels are formed from pre-existing blood vessels. Hyperglycemia has been shown to increase EC angiogenic potential. However, few studies have investigated effects of fatty acids (FAs) on EC angiogenesis. Cluster of differentiation 36 (CD36) is a FA transporter expressed by ECs, but its role in EC proliferation, migration, and angiogenesis is unknown. We sought to determine if circulating FAs regulate angiogenic function in a CD36-dependent manner. CD36-dependent effects of FAs on EC proliferation and migration of mouse heart ECs (MHECs) and lung ECs (MLECs) …

Approach To The Pan-Brachial Plexus Injury: Variation In Surgical Strategies Among Surgeons, Steven T. Lanier, J. Ryan Hill, Aimee S. James, Liz Rolf, David M. Brogan, Christopher J. Dy

Open Access Publications

No abstract provided.

A Multi-Mrna Host-Response Molecular Blood Test For The Diagnosis And Prognosis Of Acute Infections And Sepsis: Proceedings From A Clinical Advisory Panel, James Ducharme, Wesley H Self, Tiffany M Osborn, Nathan A Ledeboer, Jonathan Romanowsky, Timothy E Sweeney, Oliver Liesenfeld, Richard E Rothman

Open Access Publications

Current diagnostics are insufficient for diagnosis and prognosis of acute infections and sepsis. Clinical decisions including prescription and timing of antibiotics, ordering of additional diagnostics and level-of-care decisions rely on understanding etiology and implications of a clinical presentation. Host mRNA signatures can differentiate infectious from noninfectious etiologies, bacterial from viral infections, and predict 30-day mortality. The 29-host-mRNA blood-based InSep

Fenofibrate Reduces The Severity Of Neuroretinopathy In A Type 2 Model Of Diabetes Without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression, Jennifer M Enright, Sheng Zhang, Christina Thebeau, Emily Siebert, Alexander Jin, Veda Gadiraju, Xiaodong Zhang, Shiming Chen, Clay F Semenkovich, Rithwick Rajagopal

Open Access Publications

Fenofibrate slows the progression of clinical diabetic retinopathy (DR), but its mechanism of action in the retina remains unclear. Fenofibrate is a known agonist of peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor critical for regulating metabolism, inflammation and oxidative stress. Using a DR mouse model,

Food Addiction And Psychosocial Adversity: Biological Embedding, Contextual Factors, And Public Health Implications, David A Wiss, Nicole Avena, Mark Gold

Open Access Publications

The role of stress, trauma, and adversity particularly early in life has been identified as a contributing factor in both drug and food addictions. While links between traumatic stress and substance use disorders are well documented, the pathways to food addiction and obesity are less established. This review focuses on psychosocial and neurobiological factors that may increase risk for addiction-like behaviors and ultimately increase BMI over the lifespan. Early childhood and adolescent adversity can induce long-lasting alterations in the glucocorticoid and dopamine systems that lead to increased addiction vulnerability later in life. Allostatic load, the hypothalamic-pituitary-adrenal axis, and emerging data …

Roles Of The Vagina And The Vaginal Microbiota In Urinary Tract Infection: Evidence From Clinical Correlations And Experimental Models, Amanda L Lewis, Nicole M Gilbert

Open Access Publications

Mounting evidence indicates that the vagina can harbor uropathogenic bacteria. Here, we consider three roles played by the vagina and its bacterial inhabitants in urinary tract infection (UTI) and urinary health. First, the vagina can serve as a reservoir for

A Framework For Advancing Our Understanding Of Cancer-Associated Fibroblasts, Erik Sahai, David G. Denardo, Sheila Stewart, Et Al.

Open Access Publications

No abstract provided.

Neutrophil L-Plastin Controls Ocular Paucibacteriality And Susceptibility To Keratitis, Xiaoxiao Lu, Abirami Kugadas, Kirsten Smith-Page, Jeffrey Lamb, Tiffany Lin, Yusha Ru, Sharon Celeste Morley, Raina Fichorova, Sharad K Mittal, Sunil K Chauhan, Sejiro Littleton, Daniel Saban, Mihaela Gadjeva

Open Access Publications

Why ocular mucosa is paucibacterial is unknown. Many different mechanisms have been suggested but the comprehensive experimental studies are sparse. We found that a deficiency in L-plastin (LCP1), an actin bundling protein, resulted in an ocular commensal overgrowth, characterized with increased presence of conjunctival