Digital Commons Network^™

Long-Term Employment Outcomes Among Female Cancer Survivors, Christine C Ekenga, Eunsun Kwon, Borin Kim, Sojung Park

Open Access Publications

Advances in early detection and treatment have led to a growing population of female cancer survivors, many of whom are of working age. We examined the relationship between cancer and long-term (>5 years) employment outcomes in a nationally representative sample of working-age women in the United States. Data from nine waves of the Health and Retirement Study were used to examine employment status and weekly hours worked among cancer survivors (

Dna Double-Strand Breaks Induce H2ax Phosphorylation Domains In A Contact-Dependent Manner, Patrick L. Collins, Caitlin Purman, Sofia I. Porter, Vincent Nganga, Ankita Saini, Katharina E. Hayer, Greer L. Gurewitz, Barry P. Sleckman, Jeffrey J. Bednarski, Craig H. Bassing, Eugene M. Oltz

Open Access Publications

No abstract provided.

Enhancing The Anti-Tumour Activity Of 177lu-Dota-Octreotate Radionuclide Therapy In Somatostatin Receptor-2 Expressing Tumour Models By Targeting Parp, Carleen Cullinane, Kelly Waldeck, Laura Kirby, Buck E. Rogers, Peter Eu, Richard W. Tothill, Rodney J. Hicks

Open Access Publications

No abstract provided.

Hippocampal Volume In Provisional Tic Disorder Predicts Tic Severity At 12-Month Follow-Up, Soyoung Kim, Deanna J Greene, Carolina Badke D'Andrea, Emily C Bihun, Jonathan M Koller, Bridget O'Reilly, Bradley L Schlaggar, Kevin J Black

Open Access Publications

Previous studies have investigated differences in the volumes of subcortical structures (e.g., caudate nucleus, putamen, thalamus, amygdala, and hippocampus) between individuals with and without Tourette syndrome (TS), as well as the relationships between these volumes and tic symptom severity. These volumes may also predict clinical outcome in Provisional Tic Disorder (PTD), but that hypothesis has never been tested. This study aimed to examine whether the volumes of subcortical structures measured shortly after tic onset can predict tic symptom severity at one-year post-tic onset, when TS can first be diagnosed. We obtained T1-weighted structural MRI scans from 41 children with PTD …

Genetic Aetiology Of Self-Harm Ideation And Behaviour, Adrian I. Campos, Karin J. H. Verweij, Dixie J. Statham, Pamela A. F. Madden, Dominique F. Maciejewski, Katrina A. S. Davis, Ann John, Matthew Hotopf, Andrew C. Heath, Nicholas G. Martin, Miguel E. Rentería

Open Access Publications

No abstract provided.

A Mobile Health App For The Collection Of Functional Outcomes After Inpatient Stroke Rehabilitation: Pilot Randomized Controlled Trial, Li Li, Jia Huang, Jingsong Wu, Cai Jiang, Shanjia Chen, Guanli Xie, Jinxin Ren, Jing Tao, Chetwyn C H Chan, Lidian Chen, Alex W K Wong

Open Access Publications

BACKGROUND: Monitoring the functional status of poststroke patients after they transition home is significant for rehabilitation. Mobile health (mHealth) technologies may provide an opportunity to reach and follow patients post discharge. However, the feasibility and validity of functional assessments administered by mHealth technologies are unknown.

OBJECTIVE: This study aimed to evaluate the feasibility, validity, and reliability of functional assessments administered through the videoconference function of a mobile phone-based app compared with administration through the telephone function in poststroke patients after rehabilitation hospitalization.

METHODS: A randomized controlled trial was conducted in a rehabilitation hospital in Southeast China. Participants were randomly assigned …

End Of An Era Of Administering Erythropoiesis Stimulating Agents Among Veterans Administration Cancer Patients With Chemotherapy-Induced Anemia, Shamia Hoque, Brian J. Chen, Martin W. Schoen, Kenneth R. Carson, Jesse Keller, Bartlett J. Witherspoon, Kevin B. Knopf, Y Tony Yang, Benjamin Schooley, Chadi Nabhan, Oliver Sartor, Paul R. Yarnold, Paul Ray, Laura Bobolts, William J. Hrushesky, Michael Dickson, Charles L. Bennett

Open Access Publications

Erythropoisis stimulating agent (ESA) use was addressed in Food and Drug Administration (FDA) Oncology Drug Advisory Committee (ODAC) meetings between 2004 and 2008. FDA safety-focused regulatory actions occurred in 2007 and 2008. In 2007, black box warnings advised of early death and venous thromboembolism (VTE) risks with ESAs in oncology. In 2010, a Risk Evaluation Strategies (REMS) was initiated, with cancer patient consent that mortality and VTE risks were noted with ESAs. We report warnings and REMS impacts on ESA utilization among Veterans Administration (VA) cancer patients with chemotherapy-induced anemia (CIA). Data were from Veterans Affairs database (2003-2012). Epoetin and …

Carpal Tunnel Syndrome And Exposure To Work-Related Biomechanical Stressors And Chemicals: Findings From The Constances Cohort, Yves Roquelaure, Ronan Garlantézec, Vincent Rousseau, Alexis Descatha, Bradley Evanoff, Stefano Mattioli, Marcel Goldberg, Marie Zins, Julie Bodin

Open Access Publications

OBJECTIVE: To investigate the effects of co-exposure to biomechanical wrist stressors and chemicals on the risk of CTS in a large cohort of French workers.

METHODS: Prospective study using the data collected at baseline and at the first 12 month-follow-up for the 18,018 participants included in the population-based Constances cohort between 2012 and 2015. CTS at follow-up and exposure to biomechanical wrist stressors and chemicals at baseline were assessed using a self-administered questionnaire. Associations between CTS and co-exposure to biomechanical wrist stressors and chemicals were studied using multivariate logistic regression models, adjusted for personal/medical factors.

RESULTS: 184 men (2.1%, 95%CI …

Combined Abdominal Heterotopic Heart And Aorta Transplant Model In Mice, Hao Dun, Li Ye, Yuehui Zhu, Brian W Wong

Open Access Publications

BACKGROUND: Allograft vasculopathy (AV) remains a major obstacle to long-term allograft survival. While the mouse aortic transplantation model has been proven as a useful tool for study of the pathogenesis of AV, simultaneous transplantation of the aorta alongside the transplantation of another organ may reveal more clinically relevant mechanisms that contribute to the pathogenesis of chronic allograft rejection. Therefore, we developed a combined abdominal heart and aorta transplantation model in mice which benefits from reducing animal and drug utilization, while providing an improved model to study the progressive nature of AV.

METHODS: The middle of the infrarenal aorta of the …

Mental Health And Weather Extremes In A Southeastern U.S. City: Exploring Group Differences By Race, Lisa Reyes Mason, Bonita B Sharma, Jayme E Walters, Christine C Ekenga

Open Access Publications

The connection between mental health and weather extremes is a public health concern, but less studied to date than physical health. This exploratory study examines the mental health impacts of two kinds of weather extremes increasingly linked to climate change-summer heat waves and extreme winter weather-in a low- to middle-income population in the Southeastern U.S. The distribution of mental health impacts, and potential pathways to them, are examined with a focus on race. Data are from a random-sample survey of 426 participants and are analyzed with bivariate statistics and path analysis. Self-reported mental health impacts, in both seasons, were common …

Improved Ecg Watermarking Technique Using Curvelet Transform, Lalit Mohan Goyal, Mamta Mittal, Ranjeeta Kaushik, Amit Verma, Iqbaldeep Kaur, Sudipta Roy, Tai-Hoon Kim

Open Access Publications

Hiding data in electrocardiogram signals are a big challenge due to the embedded information that can hamper the accuracy of disease detection. On the other hand, hiding data into ECG signals provides more security for, and authenticity of, the patient's data. Some recent studies used non-blind watermarking techniques to embed patient information and data of a patient into ECG signals. However, these techniques are not robust against attacks with noise and show a low performance in terms of parameters such as peak signal to noise ratio (PSNR), normalized correlation (NC), mean square error (MSE), percentage residual difference (PRD), bit error …

The Transcription Factor Eb Reduces The Intraneuronal Accumulation Of The Beta-Secretase-Derived App Fragment C99 In Cellular And Mouse Alzheimer’S Disease Models, Anaïs Bécot, Raphaëlle Pardossi-Piquard, Alexandre Bourgeois, Eric Duplan, Qingli Xiao, Abhinav Diwan, Jin-Moo Lee, Inger Lauritzen, Frédéric Checler

Open Access Publications

No abstract provided.

Feasibility And Validity Of A Low-Cost Racing Simulator In Driving Assessment After Stroke, Jonathan Tiu, Annie C Harmon, James D Stowe, Amen Zwa, Marc Kinnear, Latch Dimitrov, Tina Nolte, David B Carr

Open Access Publications

There is a myriad of methodologies to assess driving performance after a stroke. These include psychometric tests, driving simulation, questionnaires, and/or road tests. Research-based driving simulators have emerged as a safe, convenient way to assess driving performance after a stroke. Such traditional research simulators are useful in recreating street traffic scenarios, but are often expensive, with limited physics models and graphics rendering. In contrast, racing simulators developed for motorsport professionals and enthusiasts offer high levels of realism, run on consumer-grade hardware, and can provide rich telemetric data. However, most offer limited simulation of traffic scenarios. This pilot study compares the …

Malaria Parasite Plasmepsins: More Than Just Plain Old Degradative Pepsins, Armiyaw S. Nasamu, Alexander J. Polino, Eva S. Istvan, Daniel E. Goldberg

Open Access Publications

No abstract provided.

19f Nmr Reveals The Conformational Properties Of Free Thrombin And Its Zymogen Precursor Prethrombin-2, Eliza A. Ruben, Prafull S. Gandhi, Zhiwei Chen, Sarah K. Koester, Gregory T. Dekoster, Carl Frieden, Enrico Di Cera

Open Access Publications

No abstract provided.

Using Polygenic Scores For Identifying Individuals At Increased Risk Of Substance Use Disorders In Clinical And Population Samples, Peter B. Barr, Emma C. Johnson, Andrey Anokhin, Arpana Agrawal, Et Al.

Open Access Publications

No abstract provided.

The Chromatin Remodeling Enzyme Chd4 Regulates Genome Architecture In The Mouse Brain, Jared V. Goodman, Tomoko Yamada, Yue Yang, Lingchun Kong, Dennis Y. Wu, Guoyan Zhao, Harrison W. Gabel, Azad Bonni

Open Access Publications

No abstract provided.

Safety And Efficacy Outcomes Of The Xen45 Gel Stent Use For Refractory Glaucoma: A Surgery Series From Surgeon Trainees At A Tertiary Teaching Hospital, Karen Hong, John Lind, Arsham Sheybani

Open Access Publications

Background: To study the effect of an ab interno gelatin stent (XEN45 Gel Stent, Allergan Inc., Irvine, California, USA) on intraocular pressure (IOP) as placed by glaucoma fellowship trainees in eyes with refractory glaucoma.

Methods: A prospective noncomparative study at a tertiary training center on 28 unique eyes undergoing ab interno gelatin stent implantation by glaucoma fellowship trainees. Data was collected at baseline and postoperatively at day 1, week 1, and months 1, 3, 5, and 12. Primary outcome was mean IOP change. Secondary outcomes included change in number of glaucoma medication classes and visual acuity. Safety outcomes included needling …

Single-Cell Rna-Seq Analysis Of Human Csf Microglia And Myeloid Cells In Neuroinflammation, Ekaterina Esaulova, Claudia Cantoni, Irina Shchukina, Konstantin Zaitsev, Robert C. Bucelli, Gregory F. Wu, Maxim N. Artyomov, Anne H. Cross, Brian T. Edelson

Open Access Publications

No abstract provided.

Challenges And Solutions For The Implementation Of Shared Decision-Making In Breast Reconstruction, Terence M. Myckatyn, Rajiv P. Parikh, Clara Lee, Mary C. Politi

Open Access Publications

No abstract provided.

Foot Salvage With Selective Arterialization Of Pedal Venosomes, Maleeh Effendi, Austin Y. Ha, John M. Felder Iii

Open Access Publications

No abstract provided.

Combination Of Dasatinib With Chemotherapy In Previously Untreated Core Binding Factor Acute Myeloid Leukemia: Calgb 10801, Guido Marcucci, Geoffrey L. Uy, Et Al.

Open Access Publications

No abstract provided.

A Phase 1 Trial Of Itacitinib, A Selective Jak1 Inhibitor, In Patients With Acute Graft-Versus-Host Disease, Mark A. Schroeder, Karl Staser, Jaebok Choi, Leah Gehrs, John F. Dipersio, Et Al.

Open Access Publications

No abstract provided.

Influence Of Adiposity, Insulin Resistance, And Intrahepatic Triglyceride Content On Insulin Kinetics, Gordon I Smith, David C Polidori, Mihoko Yoshino, Monica L Kearney, Bruce W Patterson, Bettina Mittendorfer, Samuel Klein

Open Access Publications

BACKGROUNDInsulin is a key regulator of metabolic function. The effects of excess adiposity, insulin resistance, and hepatic steatosis on the complex integration of insulin secretion and hepatic and extrahepatic tissue extraction are not clear.METHODSA hyperinsulinemic-euglycemic clamp and a 3-hour oral glucose tolerance test were performed to evaluate insulin sensitivity and insulin kinetics after glucose ingestion in 3 groups: (a) lean subjects with normal intrahepatic triglyceride (IHTG) and glucose tolerance (lean-NL; n = 14), (b) obese subjects with normal IHTG and glucose tolerance (obese-NL; n = 24), and (c) obese subjects with nonalcoholic fatty liver disease (NAFLD) and prediabetes (obese-NAFLD; n …

Inhibition Of The Translesion Synthesis Polymerase Rev1 Exploits Replication Gaps As A Cancer Vulnerability, Sumeet Nayak, Jennifer A Calvo, Ke Cong, Min Peng, Emily Berthiaume, Jessica Jackson, Angela M Zaino, Alessandro Vindigni, M Kyle Hadden, Sharon B Cantor

Open Access Publications

The replication stress response, which serves as an anticancer barrier, is activated not only by DNA damage and replication obstacles but also oncogenes, thus obscuring how cancer evolves. Here, we identify that oncogene expression, similar to other replication stress-inducing agents, induces single-stranded DNA (ssDNA) gaps that reduce cell fitness. DNA fiber analysis and electron microscopy reveal that activation of translesion synthesis (TLS) polymerases restricts replication fork slowing, reversal, and fork degradation without inducing replication gaps despite the continuation of replication during stress. Consistent with gap suppression (GS) being fundamental to cancer, we demonstrate that a small-molecule inhibitor targeting the TLS …

Acceptance And Commitment Therapy Delivered Via A Mobile Phone Messaging Robot To Decrease Postoperative Opioid Use In Patients With Orthopedic Trauma: Randomized Controlled Trial, Chris A Anthony, Edward Octavio Rojas, Valerie Keffala, Natalie Ann Glass, Apurva S Shah, Benjamin J Miller, Matthew Hogue, Michael C Willey, Matthew Karam, John Lawrence Marsh

Open Access Publications

BACKGROUND: Acceptance and commitment therapy (ACT) is a pragmatic approach to help individuals decrease avoidable pain.

OBJECTIVE: This study aims to evaluate the effects of ACT delivered via an automated mobile messaging robot on postoperative opioid use and patient-reported outcomes (PROs) in patients with orthopedic trauma who underwent operative intervention for their injuries.

METHODS: Adult patients presenting to a level 1 trauma center who underwent operative fixation of a traumatic upper or lower extremity fracture and who used mobile phone text messaging were eligible for the study. Patients were randomized in a 1:1 ratio to either the intervention group, who …

Deployment Of Convalescent Plasma For The Prevention And Treatment Of Covid-19, Evan M Bloch, Brenda J Grossman, Jeffrey P Henderson, Et Al

Open Access Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has spurred a global health crisis. To date, there are no proven options for prophylaxis for those who have been exposed to SARS-CoV-2, nor therapy for those who develop COVID-19. Immune (i.e., "convalescent") plasma refers to plasma that is collected from individuals following resolution of infection and development of antibodies. Passive antibody administration through transfusion of convalescent plasma may offer the only short-term strategy for conferring immediate immunity to susceptible individuals. There are numerous examples in which convalescent plasma has been used successfully as postexposure prophylaxis …

Prevention And Management Of Dermatologic Adverse Events Associated With Tumor Treating Fields In Patients With Glioblastoma, Mario E Lacouture, Milan J Anadkat, Matthew T Ballo, Fabio Iwamoto, Suriya A Jeyapalan, Renato V La Rocca, Margaret Schwartz, Jennifer N Serventi, Martin Glas

Open Access Publications

No abstract provided.

Mapping Of The Language Network With Deep Learning, Patrick Luckett, John J Lee, Ki Yun Park, Donna Dierker, Andy G S Daniel, Benjamin A Seitzman, Carl D Hacker, Beau M Ances, Eric C Leuthardt, Abraham Z Snyder, Joshua S Shimony

Open Access Publications

No abstract provided.

Converging On Bladder Health Through Design Thinking: From An Ecology Of Influence To A Focused Set Of Research Questions, Jessica B Lewis, Sonya S Brady, Siobhan Sutcliffe, Ariana L Smith, Elizabeth R Mueller, Kyle Rudser, Alayne D Markland, Ann Stapleton, Sheila Gahagan, Shayna D Cunningham, Prevention Of Lower Urinary Tract Symptoms Plus Research Consortium

Open Access Publications

Lower urinary tract symptoms affect a substantial number of women in the United States (U.S.) and globally. In 2015, the Prevention of Lower Urinary tract Symptoms in women (PLUS) Research Consortium was funded to establish the scientific basis for prevention efforts by (1) understanding healthy bladder function and (2) identifying risk and protective factors for bladder health in women across the lifecourse. This transdisciplinary consortium generated a list of over 600 candidate risk and protective factors for bladder health in women and girls and refined and prioritized these into 29 focused research questions to inform a national longitudinal observational study …