Digital Commons Network^™

Diabetes Minimally Mediated The Association Between Pm2.5 Air Pollution And Kidney Outcomes, Benjamin Bowe, Yan Xie, Yan Yan, Hong Xian, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Pharmacological Inhibition Of Ataxia-Telangiectasia Mutated Exacerbates Acute Kidney Injury By Activating P53 Signaling In Mice, Masahiro Uehara, Tetsuro Kusaba, Tomoharu Ida, Kunihiro Nakai, Tomohiro Nakata, Aya Tomita, Noriko Watanabe-Uehara, Kisho Ikeda, Takashi Kitani, Noriyuki Yamashita, Yuhei Kirita, Satoaki Matoba, Benjamin D. Humphreys, Keiichi Tamagaki

Open Access Publications

No abstract provided.

Wikidata As A Knowledge Graph For The Life Sciences, Andra Waagmeester, Malachi Griffith, Obi L. Griffith, Et Al.

Open Access Publications

No abstract provided.

Metabolic And Addiction Indices In Patients On Opioid Agonist Medication-Assisted Treatment: A Comparison Of Buprenorphine And Methadone, Igor Elman, Margaret Howard, Jacob T. Borodovsky, David Mysels, David Rott, David Borsook, Mark Albanese

Open Access Publications

No abstract provided.

Fhir Genomics: Enabling Standardization For Precision Medicine Use Cases, Gil Alterovitz, Bret Heale, James Jones, David Kreda, Fan Lin, Lei Liu, Xin Liu, Kenneth D. Mandl, David W. Poloway, Rachel Ramoni, Alex Wagner, Jeremy L. Warner

Open Access Publications

No abstract provided.

Cns Microrna Profles: A Database For Cell Type Enriched Microrna Expression Across The Mouse Central Nervous System, Nathan Pomper, Yating Liu, Mariah L. Hoye, Joseph D. Dougherty, Timothy M. Miller

Open Access Publications

No abstract provided.

Anti-Angiogenic Effects Of Vegf Stimulation On Endothelium Deficient In Phosphoinositide Recycling, Amber N. Stratman, Olivia M. Farrelly, Constantinos M. Mikelis, Mayumi F. Miller, Zhiyong Wang, Van N. Pham, Andrew E. Davis, Margaret C. Burns, Sofia A. Pezoa, Daniel Castranova, Joseph J. Yano, Tina M. Kilts, George E. Davis, J. Silvio Gutkind, Brant M. Weinstein

Open Access Publications

No abstract provided.

Investigating The Effect Of Thyroid Nodule Location On The Risk Of Thyroid Cancer, Sina Jasim, Thomas J. Baranski, Sharlene A. Teefey, William D. Middleton

Open Access Publications

No abstract provided.

Low Burden Strategies Are Needed To Reduce Smoking In Rural Healthcare Settings: A Lesson From Cancer Clinics, Alex T Ramsey, Timothy B Baker, Giang Pham, Faith Stoneking, Nina Smock, Graham A Colditz, Aimee S James, Jingxia Liu, Laura J Bierut, Li-Shiun Chen

Open Access Publications

Rural populations face significant smoking-related health disparities, such as a higher prevalence of lung cancer and cancer mortality, higher prevalence of smoking, and lower likelihood of receiving cessation treatment than urban counterparts. A significant proportion of health disparities in rural populations could be eliminated with low-barrier, easy-access treatment delivery methods for smoking cessation. In this study, we assessed treatment engagement among patients in rural and urban settings. Then, we examined the effect of an electronic health record-based smoking cessation module on patient receipt of evidence-based cessation care. As part of a quality improvement project, we retrospectively observed 479,798 unique patients …

Family Encouragement Of Healthy Eating Predicts Child Dietary Intake And Weight Loss In Family-Based Behavioral Weight-Loss Treatment, Sophia A. Rotman, Lauren A. Fowler, Mary Katherine Ray, Richard I. Stein, Jacqueline F. Hayes, Rachel P. Kolko, Katherine N. Balantekin, Alexis Engel, Brian E. Saelens, R. Robinson Welch, Michael G. Perri, Leonard H. Epstein, Denise E. Wilfley

Open Access Publications

No abstract provided.

Advances In Vaporisation: A Narrative Review, Pankaj Kundra, Shreya Goswami, Aruna Parameswari

Open Access Publications

No abstract provided.

Identification Of The Growth Factor-Binding Sequence In The Extracellular Matrix Protein Magp-1, Thomas J. Broekelmann, Nicholas K. Bodmer, Robert P. Mecham

Open Access Publications

No abstract provided.

The Global And National Burden Of Chronic Kidney Disease Attributable To Ambient Fine Particulate Matter Air Pollution: A Modelling Study, Benjamin Bowe, Elena Artimovich, Yan Xie, Yan Yan, Miao Cai, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Movement Pattern Training Compared With Standard Strengthening And Flexibility Among Patients With Hip-Related Groin Pain: Results Of A Pilot Multicentre Randomised Clinical Trial, Marcie Harris-Hayes, Karen Steger-May, Allyn M. Bove, Stefanie N. Foster, Michael J. Mueller, John C. Clohisy, G. Kelley Fitzgerald

Open Access Publications

No abstract provided.

Reporting Guidelines, Review Of Methodological Standards, And Challenges Toward Harmonization In Bone Marrow Adiposity Research. Report Of The Methodologies Working Group Of The International Bone Marrow Adiposity Society, Josefine Tratwal, Erica L Scheller, Et Al

Open Access Publications

The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer) as well as treatments (corticosteroid, radiation, chemotherapy, thiazolidinediones). However, to advance the field of BMA research, standardization of methods is desirable to increase comparability of study outcomes and foster collaboration. Therefore, at the 2017 annual BMA meeting, the International Bone Marrow Adiposity Society (BMAS) founded a working group to evaluate methodologies in BMA research. All BMAS members could volunteer to participate. The working group members, who are all active preclinical …

Phase 1–2 Trial Of Antisense Oligonucleotide Tofersen For Sod1 Als, Timothy Miller, Robert C. Bucelli, Alan Pestronk, Et Al.

Open Access Publications

No abstract provided.

In Vivo Assessment Of Supra-Cervical Fetal Membrane By Mri 3d Ciss: A Preliminary Study, Wenxu Qi, Peinan Zhao, Wei Wang, Zhexian Sun, Xiao Ma, Hui Wang, Wenjie Wu, Zichao Wen, Zulfia Kisrieva-Ware, Pamela K Woodard, Qing Wang, Robert C Mckinstry, Yong Wang

Open Access Publications

In approximately 8% of term births and 33% of pre-term births, the fetal membrane (FM) ruptures before delivery.

Self-Perception Of Physical Function Contributes To Participation In Cognitively- And Physically-Demanding Activities After Stroke, Marjorie L Nicholas, Kari Burch, Julianne R Mitchell, Annie B Fox, Carolyn M Baum, Lisa Tabor Connor

Open Access Publications

No abstract provided.

Androgen-Influenced Polarization Of Activin A-Producing Macrophages Accompanies Post-Pyelonephritic Renal Scarring, Teri N. Hreha, Christina A. Collins, Allyssa L. Daugherty, Jessie M. Griffith, Keith A. Hruska, David A. Hunstad

Open Access Publications

No abstract provided.

The Road To Recovery: A Pilot Study Of Driving Behaviors Following Antibody-Mediated Encephalitis, Gregory S. Day, Ganesh M. Babulal, Ganesh Rajasekar, Sarah Stout, Catherine M. Roe

Open Access Publications

No abstract provided.

Targeting Unconventional Host Components For Vaccination-Induced Protection Against Tb, Elisa Nemes, Shabaana A Khader, Rosemary V Swanson, Willem A Hanekom

Open Access Publications

The current tuberculosis (TB) vaccine, Bacille Calmette-Guerin (BCG), is effective in preventing TB in young children but was developed without a basic understanding of human immunology. Most modern TB vaccine candidates have targeted CD4

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived Β Cells, Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Jeffrey R Millman

Open Access Publications

Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first

A Rare Complex Braf Mutation Involving Codon V600 And K601 In Primary Cutaneous Melanoma: Case Report, Francesca Consoli, Gianluca Barbieri, Matteo Picciolini, Daniela Medicina, Mattia Bugatti, Valeria Tovazzi, Barbara Liserre, Claudia Zambelli, Fausto Zorzi, Alfredo Berruti, Emanuele Giurisato, William Vermi

Open Access Publications

BRAF is one of the most common mutated kinases detected in human cancer, particularly in cases of primary cutaneous melanomas (PCM). Mutations of the BRAF proto-oncogene, at the p.V600 codon, has been detected in more than 50% of primary and metastatic melanoma cells in clinical samples. In addition to the most frequent BRAF p.V600E mutation, corresponding to the single base pair substitution c.1799T>A, rarer mutations, within and outside the V600 codon, have been described. Expectedly, BRAF and MEK inhibitors (or their combination) have been poorly explored as potential therapeutic strategies in metastatic melanomas harboring this rare mutation. By using …

Mitofusin 2 Dysfunction And Disease In Mice And Men, Gerald W Dorn Ii

Open Access Publications

A causal relationship between Mitofusin (MFN) 2 gene mutations and the hereditary axonal neuropathy Charcot-Marie-Tooth disease type 2A (CMT2A) was described over 15 years ago. During the intervening period much has been learned about MFN2 functioning in mitochondrial fusion, calcium signaling, and quality control, and the consequences of these MFN2 activities on cell metabolism, fitness, and development. Nevertheless, the challenge of defining the central underlying mechanism(s) linking mitochondrial abnormalities to progressive dying-back of peripheral arm and leg nerves in CMT2A is largely unmet. Here, a different perspective of why, in humans, MFN2 dysfunction preferentially impacts peripheral nerves is provided based …

Actual Causes Of Death In Relation To Media, Policy, And Funding Attention: Examining Public Health Priorities, Meagan R Pilar, Amy A Eyler, Sarah Moreland-Russell, Ross C Brownson

Open Access Publications

Despite numerous public health advancements over the last century, we continue to under-invest in prevention and public health efforts. As a result, one of the most challenging aspects of public health is prioritizing the use of limited resources. Building on the foundation of previous researchers, the goal of this exploratory study was to provide current estimates for the actual causes of death, media attention, policy focus, and research funding in the United States. In addition, we sought to calculate and compare media attention, policy attention, and research funding trends to better assess the nation's prioritization of health issues. Using a …

Outcome Of Everolimus-Based Therapy In Hormone-Receptor-Positive Metastatic Breast Cancer Patients After Progression On Palbociclib, Ajay Dhakal, Roby Antony Thomas, Ellis G. Levine, Adam Brufsky, Kazuaki Takabe, Matthew G. Hanna, Kristopher Attwood, Austin Miller, Thaer Khoury, Amy P. Early, Saif Soniwala, Tracy O'Connor, Matuesz Opyrchal

Open Access Publications

No abstract provided.

Cryptococcus Neoformans Evades Pulmonary Immunity By Modulating Xylose Precursor Transport, Lucy X. Li, Camaron R. Hole, Javier Rangel-Moreno, Shabaana A. Khader, Tamara L. Doering

Open Access Publications

No abstract provided.

Global Proteomics Analysis Of Circulating Extracellular Vesicles Isolated From Lung Transplant Recipients, Sandhya Bansal, Marissa Mcgilvrey, Krystine Garcia-Mansfield, Ritin Sharma, Ross M. Bremner, Michael A. Smith, Ramsey Hachem, Patrick Pirrotte, Thalachallour Mohanakumar

Open Access Publications

No abstract provided.

Mitigating Disruptions, And Scalability Of Radiation Oncology Physics Work During The Covid-19 Pandemic, Arash Darafsheh, Hossein Lavvafi, Reza Taleei, Rao Khan

Open Access Publications

PURPOSE: The COVID-19 pandemic has led to disorder in work and livelihood of a majority of the modern world. In this work, we review its major impacts on procedures and workflow of clinical physics tasks, and suggest alternate pathways to avoid major disruption or discontinuity of physics tasks in the context of small, medium, and large radiation oncology clinics. We also evaluate scalability of medical physics under the stress of "social distancing".

METHODS: Three models of facilities characterized by the number of clinical physicists, daily patient throughput, and equipment were identified for this purpose. For identical objectives of continuity of …

Il-17-Producing Γδ T Cells Protect Against Clostridium Difficile Infection, Yee-Shiuan Chen, Iuan-Bor Chen, Giang Pham, Tzu-Yu Shao, Hansraj Bangar, Sing Sing Way, David B Haslam

Open Access Publications

Colitis caused by Clostridium difficile infection is a growing cause of human morbidity and mortality, especially after antibiotic use in health care settings. The natural immunity of newborn infants and protective host immune mediators against C. difficile infection are not fully understood, with data suggesting that inflammation can be either protective or pathogenic. Here, we show an essential role for IL-17A produced by γδ T cells in host defense against C. difficile infection. Fecal extracts from children with C. difficile infection showed increased IL-17A and T cell receptor γ chain expression, and IL-17 production by intestinal γδ T cells was …