Digital Commons Network^™

Phase 2 Study Of Ruxolitinib And Decitabine In Patients With Myeloproliferative Neoplasm In Accelerated And Blast Phase, John O. Mascarenhas, Camille N. Abboud, Et Al.

Open Access Publications

No abstract provided.

Determining The Recommended Dose Of Pacritinib: Results From The Pac203 Dose-Finding Trial In Advanced Myelofibrosis, Aaron T. Gerds, Stephen T. Oh, Et Al.

Open Access Publications

No abstract provided.

Tp53 Abnormalities Correlate With Immune Infiltration And Associate With Response To Flotetuzumab Immunotherapy In Aml, Jayakumar Vadakekolathu, Michael P. Rettig, John F. Dipersio, Et Al.

Open Access Publications

No abstract provided.

A Feasibility Study To Evaluate Early Treatment Response Of Brain Metastases One Week After Stereotactic Radiosurgery Using Perfusion Weighted Imaging, Jiayi Huang, Mikhail Milchenko, Yuan J. Rao, Pamela Lamontagne, Christopher Abraham, Clifford G. Robinson, Yi Huang, Joshua S. Shimony, Keith M. Rich, Tammie Benzinger

Open Access Publications

BACKGROUND: To explore if early perfusion-weighted magnetic resonance imaging (PWI) may be a promising imaging biomarker to predict local recurrence (LR) of brain metastases after stereotactic radiosurgery (SRS).

METHODS: This is a prospective pilot study of adult brain metastasis patients who were treated with SRS and imaged with PWI before and 1 week later. Relative cerebral blood volume (rCBV) parameter maps were calculated by normalizing to the mean value of the contralateral white matter on PWI. Cox regression was conducted to explore factors associated with time to LR, with Bonferroni adjusted p<0.0006 for multiple testing correction. LR rates were estimated with the Kaplan-Meier method and compared using the log-rank test.

RESULTS: Twenty-three patients were enrolled from 2013 through …

High-Resolution Manometry Determinants Of Refractoriness Of Reflux Symptoms To Proton Pump Inhibitor Therapy, Mentore Ribolsi, Edoardo Savarino, Benjamin Rogers, Arvind Rengarajan, Marco Della Coletta, Matteo Ghisa, Michele Cicala, C. Prakash Gyawali

Open Access Publications

No abstract provided.

Structural Basis Of Chikungunya Virus Inhibition By Monoclonal Antibodies, Qun Fei Zhou, Julie M. Fox, James T. Earnest, Thiam-Seng Ng, Arthur S. Kim, Guntur Fibriansah, Victor A. Kostyuchenko, Jian Shi, Bo Shu, Michael S. Diamond, Shee-Mei Lok

Open Access Publications

No abstract provided.

Distinct Neural Networks Associated With Obsession And Delusion: A Connectome-Wide Association Study, Tae Young Lee, Wi Hoon Jung, Yoo Bin Kwak, Youngwoo B Yoon, Junhee Lee, Minah Kim, Euitae Kim, Jun Soo Kwon

Open Access Publications

BACKGROUND: Obsession and delusion are theoretically distinct from each other in terms of reality testing. Despite such phenomenological distinction, no extant studies have examined the identification of common and distinct neural correlates of obsession and delusion by employing biologically grounded methods. Here, we investigated dimensional effects of obsession and delusion spanning across the traditional diagnostic boundaries reflected upon the resting-state functional connectivity (RSFC) using connectome-wide association studies (CWAS).

METHODS: Our study sample comprised of 96 patients with obsessive-compulsive disorder, 75 patients with schizophrenia, and 65 healthy controls. A connectome-wide analysis was conducted to examine the relationship between obsession and delusion …

Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury And Preserves Left Ventricular Systolic Function In Rats, As Evaluated By 7t Cardiovascular Magnetic Resonance Imaging, Ziqian Xu, Wei Chen, Ruzhi Zhang, Lei Wang, Ridong Chen, Jie Zheng, Fabao Gao

Open Access Publications

No abstract provided.

Structural Basis For Effector Protein Recognition By The Dot/Icm Type Ivb Coupling Protein Complex, Hyunmin Kim, Tomoko Kubori, Kohei Yamazaki, Mi-Jeong Kwak, Suk-Youl Park, Hiroki Nagai, Joseph P. Vogel, Byung-Ha Oh

Open Access Publications

No abstract provided.

Maturational Patterns Of Left Ventricular Rotational Mechanics In Pre-Term Infants Through 1 Year Of Age, Gloria C Lehmann, Philip T Levy, Meghna D Patel, Timothy Sekarski, Hongjie Gu, Swati Choudhry, Aaron Hamvas, Gautam K Singh

Open Access Publications

BACKGROUND: Pre-mature birth impacts left ventricular development, predisposing this population to long-term cardiovascular risk. The aims of this study were to investigate maturational changes in rotational properties from the neonatal period through 1 year of age and to discern the impact of cardiopulmonary complications of pre-maturity on these measures.

METHODS: Pre-term infants (<29 weeks at birth, n = 117) were prospectively enrolled and followed to 1-year corrected age. Left ventricular basal and apical rotation, twist, and torsion were measured by two-dimensional speckle-tracking echocardiography and analysed at 32 and 36 weeks post-menstrual age and 1-year corrected age. A mixed random effects model with repeated measures analysis was used to compare rotational mechanics over time. Torsion was compared in infants with and without complications of cardiopulmonary diseases of pre-maturity, specifically bronchopulmonary dysplasia, pulmonary hypertension, and patent ductus arteriosus.

RESULTS: Torsion decreased from 32 weeks post-menstrual age to 1-year corrected age in all pre-term infants (p < 0.001). The decline from 32 to 36 weeks post-menstrual age was more pronounced in infants with cardiopulmonary complications, but was similar to healthy pre-term infants from 36 weeks post-menstrual age to 1-year corrected age. The decline was due to directional and magnitude changes in apical rotation over time (p < 0.05).

CONCLUSION: This study tracks maturational patterns of rotational mechanics in pre-term infants and reveals torsion declines from the neonatal period through 1 year. Cardiopulmonary diseases of pre-maturity may negatively impact …

Cathepsin S And Protease-Activated Receptor-2 Drive Alloimmunity And Immune Regulation In Kidney Allograft Rejection, Yutian Lei, Benjamin Ehle, Santhosh V Kumar, Susanne Müller, Solange Moll, Andrew F Malone, Benjamin D Humphreys, Joachim Andrassy, Hans-Joachim Anders

Open Access Publications

Alloantigen presentation is an essential process in acute allorejection. In this context, we speculated on a pathogenic role of cathepsin S (Cat-S), a cysteine protease known to promote antigenic peptide loading into MHC class II and to activate protease-activated receptor (PAR)-2 on intrarenal microvascular endothelial and tubular epithelial cells. Single-cell RNA sequencing and immunostaining of human kidney allografts confirmed Cat-S expression in intrarenal mononuclear phagocytes.

Come Together: Protein Assemblies, Aggregates And The Sarcostat At The Heart Of Cardiac Myocyte Homeostasis, Moydul Islam, Abhinav Diwan, Kartik Mani

Open Access Publications

Homeostasis in vertebrate systems is contingent on normal cardiac function. This, in turn, depends on intricate protein-based cellular machinery, both for contractile function, as well as, durability of cardiac myocytes. The cardiac small heat shock protein (csHsp) chaperone system, highlighted by αB-crystallin (CRYAB), a small heat shock protein (sHsp) that forms ∼3-5% of total cardiac mass, plays critical roles in maintaining proteostatic function via formation of self-assembled multimeric chaperones. In this work, we review these ancient proteins, from the evolutionarily preserved role of homologs in protists, fungi and invertebrate systems, as well as, the role of sHsps and chaperones in …

Landscape Of Somatic Single Nucleotide Variants And Indels In Colorectal Cancer And Impact On Survival, Syed H. Zaidi, Yin Cao, Et Al.

Open Access Publications

No abstract provided.

Effects Of Early Life Exposure To Traffic-Related Air Pollution On Brain Development In Juvenile Sprague-Dawley Rats, Kelley T. Patten, Eduardo A. González, Anthony Valenzuela, Elizabeth Berg, Christopher Wallis, Joel R. Garbow, Jill L. Silverman, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein

Open Access Publications

No abstract provided.

Evolution And Structure Of Clinically Relevant Gene Fusions In Multiple Myeloma, Steven M. Foltz, Qingsong Gao, Christopher J. Yoon, Hua Sun, Lijun Yao, Yize Li, Reyka G. Jayasinghe, Song Cao, Justin King, Daniel R. Kohnen, Mark A. Fiala, Li Ding, Ravi Vij

Open Access Publications

No abstract provided.

Incipient Alcohol Use In Childhood: Early Alcohol Sipping And Its Relations With Psychopathology And Personality, Ashley L Watts, Phillip K Wood, Kristina M Jackson, Krista M Lisdahl, Mary M Heitzeg, Raul Gonzalez, Susan F Tapert, Deanna M Barch, Kenneth J Sher

Open Access Publications

Prior research has shown that sipping of alcohol begins to emerge during childhood and is potentially etiologically significant for later substance use problems. Using a large, community sample of 9- and 10-year-olds (N = 11,872; 53% female), we examined individual differences in precocious alcohol use in the form of alcohol sipping. We focused explicitly on features that are robust and well-demonstrated correlates of, and antecedents to, alcohol excess and related problems later in the lifespan, including youth- and parent-reported externalizing traits (i.e., impulsivity, behavioral inhibition and activation) and psychopathology. Seventeen percent of the sample reported sipping alcohol outside of a …

Preclinical Single Photon Emission Computed Tomography Of Alpha Particle-Emitting Radium-223, Diane S. Abou, Andrew Rittenbach, Ryan E. Tomlinson, Paige A. Finley, Benjamin Tsui, Brian W. Simons, Abhinav K. Jha, David Ulmert, Ryan C. Riddle, Daniel L. J. Thorek

Open Access Publications

No abstract provided.

Induced Remission Of Metastatic Squamous Cell Carcinoma With An Immune Checkpoint Inhibitor In A Patient With Recessive Dystrophic Epidermolysis Bullosa, Karam Khaddour, Emily S. Gorell, Farrokh Dehdashti, Jean Y. Tang, George Ansstas

Open Access Publications

No abstract provided.

Work-Related And Personal Factors Associated With Mental Well-Being During The Covid-19 Response: Survey Of Health Care And Other Workers, Bradley A Evanoff, Jaime R Strickland, Ann Marie Dale, Lisa Hayibor, Emily Page, Jennifer G Duncan, Thomas Kannampallil, Diana L Gray

Open Access Publications

BACKGROUND: The response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created an unprecedented disruption in work conditions. This study describes the mental health and well-being of workers both with and without clinical exposure to patients with coronavirus disease (COVID-19).

OBJECTIVE: The aim of this study is to measure the prevalence of stress, anxiety, depression, work exhaustion, burnout, and decreased well-being among faculty and staff at a university and academic medical center during the SARS-CoV-2 pandemic and describe work-related and personal factors associated with their mental health and well-being.

METHODS: All faculty, staff, and postdoctoral fellows of …

Single-Cell Transcriptomic Analysis Identifies The Conversion Of Zebrafish Etv2-Deficient Vascular Progenitors Into Skeletal Muscle, Brendan Chestnut, Satish Casie Chetty, Andrew L. Koenig, Saulius Sumanas

Open Access Publications

No abstract provided.

Ancestral Roles Of Atypical Cadherins In Planar Cell Polarity, Maria Brooun, Alexander Klimovich, Mikhail Bashkurov, Bret J. Pearson, Robert E. Steele, Helen Mcneill

Open Access Publications

No abstract provided.

Time-Series Cardiovascular Risk Factors And Receipt Of Screening For Breast, Cervical, And Colon Cancer: The Guideline Advantage, Aixia Guo, Bettina F. Drake, Yosef M. Khan, James R. Langabeer Ii, Randi E. Foraker

Open Access Publications

BACKGROUND: Cancer is the second leading cause of death in the United States. Cancer screenings can detect precancerous cells and allow for earlier diagnosis and treatment. Our purpose was to better understand risk factors for cancer screenings and assess the effect of cancer screenings on changes of Cardiovascular health (CVH) measures before and after cancer screenings among patients.

METHODS: We used The Guideline Advantage (TGA)-American Heart Association ambulatory quality clinical data registry of electronic health record data (n = 362,533 patients) to investigate associations between time-series CVH measures and receipt of breast, cervical, and colon cancer screenings. Long short-term memory …

Ischemia Reperfusion Injury Provokes Adverse Left Ventricular Remodeling In Dysferlin‑Deficient Hearts Through A Pathway That Involves Tirap Dependent Signaling, Sarah Evans, Carla J. Weinheimer, Attila Kovacs, Jesse W. Williams, Gwendalyn J. Randolph, Wenlong Jiang, Philip M. Barger, Douglas L. Mann

Open Access Publications

No abstract provided.

Lego‑Compatible Modular Mapping Phantom For Magnetic Resonance Imaging, Hyo-Min Cho, Cheolpyo Hong, Changwoo Lee, Huanjun Ding, Taeho Kim, Bongyoung Ahn

Open Access Publications

No abstract provided.

Comprehensive Identification Of Mrna Isoforms Reveals The Diversity Of Neural Cell-Surface Molecules With Roles In Retinal Development And Disease, Thomas A. Ray, Martha A. Cady, William J. Spencer, Philip A. Ruzycki, Brian S. Clark, Et Al.

Open Access Publications

No abstract provided.

Parcel-Guided Rtms For Depression, M. Moreno Ortega, A. Kangarlu, S. Lee, T. Perera, J. Kangarlu, T. Palomo, M.F. Glasser, D.C. Javitt

Open Access Publications

No abstract provided.

Knowledge Base And Perceptions Of Inpatient Providers And Parents About Influenza Vaccination In Hospitalized Children, Shakila Mathew, Mythili Srinivasan

Open Access Publications

No abstract provided.

The Genetic Architecture Of Human Brainstem Structures And Their Involvement In Common Brain Disorders, Torbjørn Elvsåshagen, Deanna M. Barch, Et Al.

Open Access Publications

No abstract provided.

Platelet Α-Granules Are Required For Occlusive High-Shear-Rate Thrombosis, Dongjune A. Kim, Katrina J. Ashworth, Jorge Di Paola, David N. Ku

Open Access Publications

No abstract provided.

Chimerism In The Realm Of Hematopoietic Stem Cell Transplantation For Non-Malignant Disorders-A Perspective, Clare Zimmerman, Shalini Shenoy

Open Access Publications

Hematopoietic stem cell transplantation (HCT) is a curative intervention in non-malignant disorders (NMD) that benefit from donor-derived hematopoiesis, immunity, and establishment of vital cells or enzyme systems. Stability or reversal of disease symptoms depends on adequacy and long-term stability of donor cell engraftment in the compartment of interest. Unlike hematologic malignancies where complete replacement with donor derived hematopoiesis is desirable for a cure, NMD manifestations can often be controlled in the presence of mixed chimerism. This allows for exploration of reduced intensity conditioning regimens that can limit organ toxicity, late effects, and increase tolerability especially in young recipients or those …