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Structural Changes In The Forefoot Of Individuals With Diabetes And A Prior Plantar Ulcer, Douglas D. Robertson, Michael J. Mueller, Kirk E. Smith, Paul K. Commean, Thomas Pilgrim, Jeffrey E. Johnson Aug 2002

Structural Changes In The Forefoot Of Individuals With Diabetes And A Prior Plantar Ulcer, Douglas D. Robertson, Michael J. Mueller, Kirk E. Smith, Paul K. Commean, Thomas Pilgrim, Jeffrey E. Johnson

Open Access Publications

No abstract provided.


Assessing Allele Frequencies Of Single Nucleotide Polymorphisms In Dna Pools By Pyrosequencing Technology, Jon Wasson, Gary Skolnick, Latisha Love-Gregory, M. Alan Permutt May 2002

Assessing Allele Frequencies Of Single Nucleotide Polymorphisms In Dna Pools By Pyrosequencing Technology, Jon Wasson, Gary Skolnick, Latisha Love-Gregory, M. Alan Permutt

Open Access Publications

Single nucleotide polymorphism (SNP) association studies searching for differences in allele frequencies between cases and controls have been widely used for genetic analysis. Individual genotyping is prohibitively expensive in large sample sizes. Pooling of samples provides the obvious advantage of higher throughput and lower cost. Here we report our results with the analysis of SNP allele frequencies in DNA pools using Pyrosequencing technology. For seven different SNPs, we observed a mean difference of 1.1 +/- 0.6% between allele frequencies determined in two different DNA pools (n = 150 cases and 150 controls) compared to individually genotyped samples.


Neural Systems For Visual Orienting And Their Relationships To Spatial Working Memory, Maurizio Corbetta, J. Michelle Kincade, Gordon Shulman Apr 2002

Neural Systems For Visual Orienting And Their Relationships To Spatial Working Memory, Maurizio Corbetta, J. Michelle Kincade, Gordon Shulman

Open Access Publications

We investigated neural correlates of human visual orienting using event-related functional magnetic resonance imaging (fMRI). When subjects voluntarily directed attention to a peripheral location, we recorded robust and sustained signals uniquely from the intraparietal sulcus (IPs) and superior frontal cortex (near the frontal eye field, FEF). In the ventral IPs and FEF only, the blood oxygen level dependent signal was modulated by the direction of attention. The IPs and FEF also maintained the most sustained level of activation during a 7-sec delay, when subjects maintained attention at the peripheral cued location (working memory). Therefore, the IPs and FEF form a …


Surgical Correction Of The Snapping Iliopsoas Tendon In Adolescents, Matthew B. Dobbs, J. Eric Gordon, Scott J. Luhmann, Deborah A. Szymanski, Perry L. Schoenecker Mar 2002

Surgical Correction Of The Snapping Iliopsoas Tendon In Adolescents, Matthew B. Dobbs, J. Eric Gordon, Scott J. Luhmann, Deborah A. Szymanski, Perry L. Schoenecker

Open Access Publications

No abstract provided.


Proteasome Regulates The Delivery Of Ldl Receptor-Related Protein Into The Degradation Pathway, Lora Melman, Hans J. Geuze, Yonghe Li, Lynn M. Mccormick, Peter Van Kerkhof, Ger J. Strous, Alan L. Schwartz, Guojun Bu Jan 2002

Proteasome Regulates The Delivery Of Ldl Receptor-Related Protein Into The Degradation Pathway, Lora Melman, Hans J. Geuze, Yonghe Li, Lynn M. Mccormick, Peter Van Kerkhof, Ger J. Strous, Alan L. Schwartz, Guojun Bu

Open Access Publications

No abstract provided.


Discrimination Between Paralogs Using Microarray Analysis: Application To The Yap1p And Yap2p Transcriptional Networks, Barak A. Cohen, Yitzhak Pilpel, Robi D. Mitra, George M. Church Jan 2002

Discrimination Between Paralogs Using Microarray Analysis: Application To The Yap1p And Yap2p Transcriptional Networks, Barak A. Cohen, Yitzhak Pilpel, Robi D. Mitra, George M. Church

Open Access Publications

No abstract provided.


Clinical Decision Making Based On Data From Gdx: One Year Observations, James C. Bobrow Jan 2002

Clinical Decision Making Based On Data From Gdx: One Year Observations, James C. Bobrow

Open Access Publications

No abstract provided.


Bacterial Infectious Disease Control By Vaccine Development, Roy Curtiss Iii Jan 2002

Bacterial Infectious Disease Control By Vaccine Development, Roy Curtiss Iii

Open Access Publications

No abstract provided.


Heparin Cofactor Ii Inhibits Arterial Thrombosis After Endothelial Injury, Li He, Cristina P. Vicente, Randal J. Westrick, Daniel T. Eitzman, Douglas M. Tollefsen Jan 2002

Heparin Cofactor Ii Inhibits Arterial Thrombosis After Endothelial Injury, Li He, Cristina P. Vicente, Randal J. Westrick, Daniel T. Eitzman, Douglas M. Tollefsen

Open Access Publications

No abstract provided.


Astrocyte-Specific Inactivation Of The Neurofibromatosis 1 Gene (Nf1) Is Insufficient For Astrocytoma Formation, Michaela Livia Bajenaru, Yuan Zhu, Nicole M. Hedrick, Jessica Donahoe, Luis F. Parada, David H. Gutmann Jan 2002

Astrocyte-Specific Inactivation Of The Neurofibromatosis 1 Gene (Nf1) Is Insufficient For Astrocytoma Formation, Michaela Livia Bajenaru, Yuan Zhu, Nicole M. Hedrick, Jessica Donahoe, Luis F. Parada, David H. Gutmann

Open Access Publications

No abstract provided.


The Role Of Nh2-Terminal Positive Charges In The Activity Of Inward Rectifier Katp Channels, Catherine A. Cukras, Iana Jeliazkova, Colin G. Nichols Jan 2002

The Role Of Nh2-Terminal Positive Charges In The Activity Of Inward Rectifier Katp Channels, Catherine A. Cukras, Iana Jeliazkova, Colin G. Nichols

Open Access Publications

No abstract provided.


Structural And Functional Determinants Of Conserved Lipid Interaction Domains Of Inward Rectifying Kir6.2 Channels, Catherine A. Cukras, Iana Jeliazkova, Colin G. Nichols Jan 2002

Structural And Functional Determinants Of Conserved Lipid Interaction Domains Of Inward Rectifying Kir6.2 Channels, Catherine A. Cukras, Iana Jeliazkova, Colin G. Nichols

Open Access Publications

No abstract provided.


The Sur7p Family Defines Novel Cortical Domains In Saccharomyces Cerevisiae, Affects Sphingolipid Metabolism, And Is Involved In Sporulation, Michael E. Young, Tatiana S. Karpova, Britta Brugger, Darcy M. Moschenross, Georgeann K. Wang, Roger Schneiter, Felix T. Wieland, John A. Cooper Jan 2002

The Sur7p Family Defines Novel Cortical Domains In Saccharomyces Cerevisiae, Affects Sphingolipid Metabolism, And Is Involved In Sporulation, Michael E. Young, Tatiana S. Karpova, Britta Brugger, Darcy M. Moschenross, Georgeann K. Wang, Roger Schneiter, Felix T. Wieland, John A. Cooper

Open Access Publications

No abstract provided.


Dynamic Interplay Between Adhesive And Lateral E-Cadherin Dimers, Jorg Klingelhofer, Oscar Y. Laur, Regina B. Troyanovsky, Sergey M. Troyanovsky Jan 2002

Dynamic Interplay Between Adhesive And Lateral E-Cadherin Dimers, Jorg Klingelhofer, Oscar Y. Laur, Regina B. Troyanovsky, Sergey M. Troyanovsky

Open Access Publications

No abstract provided.


Regulation Of Lutropin Circulatory Half-Life By The Mannose/N-Acetylgalactosamine-4-So4 Receptor Is Critical For Implantation In Vivo, Yiling Mi, Steven D. Shapiro, Jacques U. Baenziger Jan 2002

Regulation Of Lutropin Circulatory Half-Life By The Mannose/N-Acetylgalactosamine-4-So4 Receptor Is Critical For Implantation In Vivo, Yiling Mi, Steven D. Shapiro, Jacques U. Baenziger

Open Access Publications

No abstract provided.


The Cardiac Phenotype Induced By Pparα Overexpression Mimics That Caused By Diabetes Mellitus, Brian N. Finck, John J. Lehman, Teresa C. Leone, Michael J. Welch, Michael J. Bennett, Attila Kovacs, Xianlin Han, Richard W. Gross, Ray Kozak, Gary D. Lopaschuk, Daniel P. Kelly Jan 2002

The Cardiac Phenotype Induced By Pparα Overexpression Mimics That Caused By Diabetes Mellitus, Brian N. Finck, John J. Lehman, Teresa C. Leone, Michael J. Welch, Michael J. Bennett, Attila Kovacs, Xianlin Han, Richard W. Gross, Ray Kozak, Gary D. Lopaschuk, Daniel P. Kelly

Open Access Publications

No abstract provided.


Cytoskeleton Of Apicomplexan Parasites, Naomi S. Morrissette, L. David Sibley Jan 2002

Cytoskeleton Of Apicomplexan Parasites, Naomi S. Morrissette, L. David Sibley

Open Access Publications

No abstract provided.


Alkaline Phosphatase Reporter Transposon For Identification Of Genes Encoding Secreted Proteins In Gram-Positive Microorganisms, Carmela M. Gibson, Michael G. Caparon Jan 2002

Alkaline Phosphatase Reporter Transposon For Identification Of Genes Encoding Secreted Proteins In Gram-Positive Microorganisms, Carmela M. Gibson, Michael G. Caparon

Open Access Publications

No abstract provided.


Myeloperoxidase Produces Nitrating Oxidants In Vivo, Joseph P. Gaut, Jaeman Byun, Hung D. Tran, Wendy M. Lauber, James A. Carroll, Richard S. Hotchkiss, Abderrazzaq Belaaouaj, Jay W. Heinecke Jan 2002

Myeloperoxidase Produces Nitrating Oxidants In Vivo, Joseph P. Gaut, Jaeman Byun, Hung D. Tran, Wendy M. Lauber, James A. Carroll, Richard S. Hotchkiss, Abderrazzaq Belaaouaj, Jay W. Heinecke

Open Access Publications

No abstract provided.


1,25-Dihydroxyvitamin D3 Is A Negative Endocrine Regulator Of The Renin-Angiotensin System, Yan Chun Li, Juan Kong, Minjie Wei, Zhou-Feng Chen, Shu Q. Liu, Li-Ping Cao Jan 2002

1,25-Dihydroxyvitamin D3 Is A Negative Endocrine Regulator Of The Renin-Angiotensin System, Yan Chun Li, Juan Kong, Minjie Wei, Zhou-Feng Chen, Shu Q. Liu, Li-Ping Cao

Open Access Publications

No abstract provided.


Viral Induction Of A Chronic Asthma Phenotype And Genetic Segregation From The Acute Response, Michael J. Walter, Jeffrey D. Morton, Naohiro Kajiwara, Eugene Agapov, Michael J. Holtzman Jan 2002

Viral Induction Of A Chronic Asthma Phenotype And Genetic Segregation From The Acute Response, Michael J. Walter, Jeffrey D. Morton, Naohiro Kajiwara, Eugene Agapov, Michael J. Holtzman

Open Access Publications

No abstract provided.


Universal Snp Genotyping Assay With Fluorescence Polarization Detection, T. M. Hsu, X. Chen, S. Duan, R. D. Miller, P. Y. Kwok Sep 2001

Universal Snp Genotyping Assay With Fluorescence Polarization Detection, T. M. Hsu, X. Chen, S. Duan, R. D. Miller, P. Y. Kwok

Open Access Publications

The degree of fluorescence polarization (FP) of a fluorescent molecule is a reflection of its molecular weight (Mr). FP is therefore a useful detection methodfor homogeneous assays in which the starting reagents and products differ significantly in Mr. We have previously shown that FP is a good detection method for the single-base extension and the 5'-nuclease assays. In this report, we describe a universal, optimized single-base extension assay for genotyping single nucleotide polymorphisms (SNPs). This assay, which we named the template-directed dye-terminator incorporation assay with fluorescence polarization detection (FP-TDI), uses four spectrally distinct dye terminators to achieve universal assay conditions. …


Noncoding Rna Gene Detection Using Comparative Sequence Analysis, Elena Rivas, Sean R. Eddy Jan 2001

Noncoding Rna Gene Detection Using Comparative Sequence Analysis, Elena Rivas, Sean R. Eddy

Open Access Publications

No abstract provided.


Gray Scale Sonography Of Breast Masses In Adolescent Girls, Keith A. Kronemer, Kyung Rhee, Marilyn J. Siegel, Laura Sievert, Charles F. Hildebolt Jan 2001

Gray Scale Sonography Of Breast Masses In Adolescent Girls, Keith A. Kronemer, Kyung Rhee, Marilyn J. Siegel, Laura Sievert, Charles F. Hildebolt

Open Access Publications

No abstract provided.


Childhood Sexual Abuse And Pathogenic Parenting In The Childhood Recollections Of Adult Twin Pairs, Tara L. Mclaughlin, Andrew C. Heath, Kathleen K. Bucholz, Pamela A F Madden, Laura J. Bierut, Wendy S. Slutske, Stephen H. Dinwiddie, Dixie J. Statham, Michael P. Dunne, Nicholas G. Martin Jan 2000

Childhood Sexual Abuse And Pathogenic Parenting In The Childhood Recollections Of Adult Twin Pairs, Tara L. Mclaughlin, Andrew C. Heath, Kathleen K. Bucholz, Pamela A F Madden, Laura J. Bierut, Wendy S. Slutske, Stephen H. Dinwiddie, Dixie J. Statham, Michael P. Dunne, Nicholas G. Martin

Open Access Publications

No abstract provided.