Digital Commons Network^™

Gait Asymmetry, And Bilateral Coordination Of Gait During A Six‑Minute Walk Test In Persons With Multiple Sclerosis, Meir Plotnik, Joanne M. Wagner, Gautam Adusumilli, Amihai Gottlieb, Robert T. Naismith

Open Access Publications

No abstract provided.

Federated Learning In Medicine: Facilitating Multi‑Institutional Collaborations Without Sharing Patient Data, Micah J. Sheller, Brandon Edwards, G. Anthony Reina, Jason Martin, Sarthak Pati, Aikaterini Kotrotsou, Mikhail Milchenko, Weilin Xu, Daniel Marcus, Rivka R. Colen, Spyridon Bakas

Open Access Publications

No abstract provided.

The Role Of Ct-Quantified Body Composition On Longitudinal Health-Related Quality Of Life In Colorectal Cancer Patients: The Colocare Study, Biljana Gigic, Graham A Colditz, Adetunji T Toriola, Et Al

Open Access Publications

BACKGROUND: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients.

METHODS: A total of 138 …

Multi-System Factors Associated With Metatarsophalangeal Joint Deformity In Individuals With Type 2 Diabetes, Jennifer A Zellers, Michael J Mueller, Paul K Commean, Ling Chen, Hyo-Jung Jeong, Mary K Hastings

Open Access Publications

The underlying factors contributing to metatarsophalangeal joint deformity, a known precursor to skin breakdown in individuals with diabetes mellitus (DM), is likely to involve multiple body systems. The purpose of this cross-sectional study was to identify multi-system factors associated with metatarsophalangeal joint deformity in individuals with type 2 DM and peripheral neuropathy (

Applying Dimensional Psychopathology: Transdiagnostic Associations Among Regional Homogeneity, Leptin And Depressive Symptoms, Yan-Ge Wei, Jia Duan, Fay Y. Womer, Yue Zhu, Zhiyang Yin, Lingling Cui, Chao Li, Zhuang Liu, Shengnan Wei, Xiaowei Jiang, Yanbo Zhang, Xizhe Zhang, Yanqing Tang, Fei Wang

Open Access Publications

No abstract provided.

Structural Mechanism For Gating Of A Eukaryotic Mechanosensitive Channel Of Small Conductance, Zengqin Deng, Grigory Maksaev, Angela M. Schlegel, Jingying Zhang, Michael Rau, James A. J. Fitzpatrick, Elizabeth S. Haswell, Peng Yuan

Open Access Publications

No abstract provided.

Orbitofrontal-Striatal Potentiation Underlies Cocaine-Induced Hyperactivity, Sebastiano Bariselli, Nanami L. Miyazaki, Meaghan C. Creed, Alexxai V. Kravitz

Open Access Publications

No abstract provided.

Competitive Tight-Binding Inhibition Of Vkorc1 Underlies Warfarin Dosage Variation And Antidotal Efficacy, Shuang Li, Shixuan Liu, Xiaoran Roger Liu, Mengru Mira Zhang, Weikai Li

Open Access Publications

No abstract provided.

Nanotherapy Delivery Of C-Myc Inhibitor Targets Protumor Macrophages And Preserves Antitumor Macrophages In Breast Cancer, Alison K. Esser, Michael H. Ross, Francesca Fontana, Xinming Su, Ariel Gabay, Gregory C. Fox, Yalin Xu, Jingyu Xiang, Anne H. Schmieder, Xiaoxia Yang, Grace Cui, Michael Scott, Samuel Achilefu, Jay Chauhan, Steven Fletcher, Gregory M. Lanza, Katherine N. Weilbaecher

Open Access Publications

No abstract provided.

Use Of The Theory Of Planned Behavior Framework To Understand Breastfeeding Decision-Making Among Mothers Of Preterm Infants, Margaret G. Parker, Sunah S. Hwang, Emma S. Forbes, Bryanne N. Colvin, Kyria R. Brown, Eve R. Colson

Open Access Publications

No abstract provided.

The Gut Microbiome Defines Social Group Membership In Honey Bee Colonies, Cassondra L Vernier, Iris M Chin, Boahemaa Adu-Oppong, Joshua J Krupp, Joel Levine, Gautam Dantas, Yehuda Ben-Shahar

Open Access Publications

In the honey bee, genetically related colony members innately develop colony-specific cuticular hydrocarbon profiles, which serve as pheromonal nestmate recognition cues. Yet, despite high intracolony relatedness, the innate development of colony-specific chemical signatures by individual colony members is largely determined by the colony environment, rather than solely relying on genetic variants shared by nestmates. Therefore, it is puzzling how a nongenic factor could drive the innate development of a quantitative trait that is shared by members of the same colony. Here, we provide one solution to this conundrum by showing that nestmate recognition cues in honey bees are defined, at …

Canonical Signaling By Tgf Family Members In Mesenchymal Stromal Cells Is Dispensable For Hematopoietic Niche Maintenance Under Basal And Stress Conditions, Joseph Ryan Krambs, Grazia Abou Ezzi, Juo-Chin Yao, Daniel C. Link

Open Access Publications

Mesenchymal stromal cells are an important component of the bone marrow hematopoietic niche. Prior studies showed that signaling from members of the transforming growth factor (TGF) superfamily in mesenchymal stromal cells is required for normal niche development. Here, we assessed the impact of TGF family signaling on niche maintenance and stress responses by deleting Smad4 in mesenchymal stromal cells at birth, thereby abrogating canonical TGF signaling. No alteration in the number or spatial organization of CXCL12-abundant reticular (CAR) cells, osteoblasts, or adipocytes was observed in Osx-Cre, Smad4fl/fl mice, and expression of key niche factors was normal. Basal hematopoiesis and stress …

Diet-Induced Metabolic Dysregulation In Female Mice Causes Osteopenia In Adult Offspring, Yu Shi, Jessica L. Saben, Guangxu He, Kelle H. Moley, Fanxin Long

Open Access Publications

Bone mass and quality in humans are controlled by numerous genetic and environmental factors that are not fully understood. Increasing evidence has indicated that maternal metabolic dysregulation impairs multiple physiological processes in the adult offspring, but a similar effect on bone health is yet to be established. Here, we have analyzed the bones of first-generation offspring from murine dams that present metabolic syndrome due to a high-fat and high-sugar (HF/HS) diet. Micro-CT analyses show that the long bones of HF/HS offspring possess lower cortical bone mass and weaker mechanical strength than normal, even though the trabecular bone is not affected. …

Functional Profiling Of Fsh And Estradiol In Ovarian Granulosa Cell Tumors, Ulla-Maija Haltia, Marjut Pihlajoki, Noora Andersson, Lotta Mäkinen, Johanna Tapper, Alejandra Cervera, Hugo M. Horlings, Ursula Turpeinen, Mikko Anttonen, Ralf Bützow, Leila Unkila-Kallio, Olli Carpén, David B. Wilson, Markku Heikinheimo, Anniina Färkkilä

Open Access Publications

Adult-type granulosa cell tumors (AGCTs) are sex-cord derived neoplasms with a propensity for late relapse. Hormonal modulators have been used empirically in the treatment of recurrent AGCT, albeit with limited success. To provide a more rigorous foundation for hormonal therapy in AGCT, we used a multimodal approach to characterize the expressions of key hormone biomarkers in 175 tumor specimens and 51 serum samples using RNA sequencing, immunohistochemistry, RNA

Prehospital Use Of A Modified Heart Pathway And Point-Of-Care Troponin To Predict Cardiovascular Events, Jason P. Stopyra, Louis Fornage, Et Al.

Open Access Publications

CLINICAL TRIAL REGISTRATION: clinicaltrials.gov (NCT02709135).

Quantitative Definition Of Neurobehavior, Vision, Hearing And Brain Volumes In Macaques Congenitally Exposed To Zika Virus, Michelle R. Koenig, Kevin Noguchi, Et Al.

Open Access Publications

Congenital Zika virus (ZIKV) exposure results in a spectrum of disease ranging from severe birth defects to delayed onset neurodevelopmental deficits. ZIKV-related neuropathogenesis, predictors of birth defects, and neurodevelopmental deficits are not well defined in people. Here we assess the methodological and statistical feasibility of a congenital ZIKV exposure macaque model for identifying infant neurobehavior and brain abnormalities that may underlie neurodevelopmental deficits. We inoculated five pregnant macaques with ZIKV and mock-inoculated one macaque in the first trimester. Following birth, growth, ocular structure/function, brain structure, hearing, histopathology, and neurobehavior were quantitatively assessed during the first week of life. We identified …

Relationship Of Amyloid Beta And Neurofibrillary Tau Deposition In Neurodegeneration In Aging Down Syndrome (Niad) Study At Baseline, D L Tudorascu, C M Laymon, M Zammit, D S Minhas, S J Anderson, P A Ellison, S Zaman, B M Ances, M Sabbagh, S C Johnson, C A Mathis, W E Klunk, B L Handen, B T Christian, A D Cohen

Open Access Publications

Importance: Adults with Down syndrome (DS) are at high-risk of revealing Alzheimer's disease (AD) pathology, in part due to the triplication of chromosome 21 encoding the amyloid precursor protein. Adults with DS are uniformly affected by AD pathology by their 30's and have a 70% to 80% chance of clinical dementia by their 60's. Our previous studies have assessed longitudinal changes in amyloid beta (Aβ) accumulation in DS.

Objective: The goal of the present study was to assess the presence of brain tau using [

Design: Cohort study.

Setting: Multi-center study.

Participants: Participants consisted of a sample of individuals with …

Effects Of Personality On The Developmental Trajectories Of Academic Burnout Among Korean Medical Students, Han Chae, C. Robert Cloninger, Soon Jin Lee

Open Access Publications

No abstract provided.

Evaluation Of Naturalistic Driving Behavior Using In-Vehicle Monitoring Technology In Preclinical And Early Alzheimer's Disease, Jennifer D Davis, Ganesh M Babulal, George D Papandonatos, Erin M Burke, Christopher B Rosnick, Brian R Ott, Catherine M Roe

Open Access Publications

Cognitive impairment is a significant risk factor for hazardous driving among older drivers with Alzheimer's dementia, but little is known about how the driving behavior of mildly symptomatic compares with those in the preclinical, asymptomatic phase of Alzheimer's disease (AD). This study utilized two in-car technologies to characterize driving behavior in symptomatic and preclinical AD. The goals of this pilot study were to (1) describe unsafe driving behaviors in individuals with symptomatic early AD using G-force triggered video capture and (2) compare the driving habits of these symptomatic AD drivers to two groups of cognitively normal drivers, those with and …

High-Throughput Analysis Of Adaptation Using Barcoded Strains Of Saccharomyces Cerevisiae, Vincent J Fasanello, Ping Liu, Carlos A Botero, Justin C Fay

Open Access Publications

Background: Experimental evolution of microbes can be used to empirically address a wide range of questions about evolution and is increasingly employed to study complex phenomena ranging from genetic evolution to evolutionary rescue. Regardless of experimental aims, fitness assays are a central component of this type of research, and low-throughput often limits the scope and complexity of experimental evolution studies. We created an experimental evolution system in

Results: We first confirm that barcode insertions do not alter fitness and that barcode sequencing can be used to efficiently detect fitness differences via pooled competition-based fitness assays. Next, we examine the effects …

Fenofibrate Prevents Iron Induced Activation Of Canonical Wnt/Β-Catenin And Oxidative Stress Signaling In The Retina, Ashok Mandala, Austin Armstrong, Becky Girresch, Jiyao Zhu, Aruna Chilakala, Sanmathi Chavalmane, Kapil Chaudhary, Pratim Biswas, Judith Ogilvie, Jaya P. Gnana-Prakasam

Open Access Publications

No abstract provided.

Discovery Of Driver Non-Coding Splice-Site-Creating Mutations In Cancer, Song Cao, Daniel Cui Zhou, Clara Oh, Reyka G. Jayasinghe, Yanyan Zhao, Christopher J. Yoon, Matthew A. Wyczalkowski, Matthew H. Bailey, Terrence Tsou, Qingsong Gao, Andrew Malone, Sheila Reynolds, Ilya Shmulevich, Michael C. Wendl, Feng Chen, Li Ding

Open Access Publications

No abstract provided.

Genomic Profiling Of Circulating Tumor Dna From Cerebrospinal Fluid To Guide Clinical Decision Making For Patients With Primary And Metastatic Brain Tumors, Lori A Ramkissoon, Sonika Dahiya, Et Al.

Open Access Publications

Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished …

Cd19 Antibody-Drug Conjugate Therapy In Dlbcl Does Not Preclude Subsequent Responses To Cd19-Directed Car T-Cell Therapy, Bicky Thapa, Paolo F. Caimi, Kirit M. Ardeshna, Melhem Solh, Carmelo Carlo-Stella, Brad S. Kahl, Mehdi Hamadani

Open Access Publications

No abstract provided.

Hitting The Target: Natural History Of The Hip Based On Achieving An Acetabular Safe Zone Following Periacetabular Osteotomy, Cody C Wyles, Juan S Vargas, Mark J Heidenreich, Kristin C Mara, Christopher L Peters, John C Clohisy, Robert T Trousdale, Rafael J Sierra

Open Access Publications

BACKGROUND: Periacetabular osteotomy (PAO) remains the gold-standard treatment for acetabular dysplasia in skeletally mature patients with preserved cartilage. The purpose of this multicenter cohort study was to delineate the long-term radiographic natural history of the dysplastic hip following PAO based on the final position of the acetabular fragment.

METHODS: We evaluated patients who underwent PAO performed by 4 hip preservation surgeons to treat acetabular dysplasia with or without concomitant retroversion from 1996 to 2012 at 3 academic institutions. There were 288 patients with a mean clinical and radiographic follow-up of 9 years (range, 5 to 21 years). Postoperative radiographs made …

A Harmonized Meta-Knowledgebase Of Clinical Interpretations Of Somatic Genomic Variants In Cancer, Alex H. Wagner, Kilannin Krysiak, Malachi Griffith, Obi L. Griffith, Et Al.

Open Access Publications

No abstract provided.

Chikungunya Virus Strains From Each Genetic Clade Bind Sulfated Glycosaminoglycans As Attachment Factors, Nicole Mcallister, Michael S. Diamond, Et Al

Open Access Publications

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes debilitating musculoskeletal disease. CHIKV displays broad cell, tissue, and species tropism, which may correlate with the attachment factors and entry receptors used by the virus. Cell surface glycosaminoglycans (GAGs) have been identified as CHIKV attachment factors. However, the specific types of GAGs and potentially other glycans to which CHIKV binds and whether there are strain-specific differences in GAG binding are not fully understood. To identify the types of glycans bound by CHIKV, we conducted glycan microarray analyses and discovered that CHIKV preferentially binds GAGs. Microarray results also indicate that sulfate groups …

Expanding The Genetic Architecture Of Nicotine Dependence And Its Shared Genetics With Multiple Traits, Bryan C. Quach, Michael J. Bray, Pamela Madden, Laura J. Bierut, Nancy L. Saccone, Et Al.

Open Access Publications

No abstract provided.

Tumor Microenvironment-Targeted Nanoparticles Loaded With Bortezomib And Rock Inhibitor Improve Efficacy In Multiple Myeloma, Cinzia Federico, Kinan Alhallak, Jennifer Sun, Kathleen Duncan, Feda Azab, Gail P. Sudlow, Pilar De La Puente, Barbara Muz, Vaishali Kapoor, Luna Zhang, Fangzheng Yuan, Matea Markovic, Joseph Kotsybar, Katherine Wasden, Nicole Guenthner, Shannon Gurley, Justin King, Daniel Kohnen, Noha N. Salama, Dinesh Thotala, Dennis E. Hallahan, Ravi Vij, John F. Dipersio, Samuel Achilefu, Abdel Kareem Azab

Open Access Publications

No abstract provided.

Stretchable, Dynamic Covalent Polymers For Soft, Long-Lived Bioresorbable Electronic Stimulators Designed To Facilitate Neuromuscular Regeneration, Yeon Sik Choi, Ying Yan, Matthew R. Macewan, Wilson Z. Ray, Et Al.

Open Access Publications

No abstract provided.