Digital Commons Network^™

Clinical And Functional Significance Of Circular Rnas In Cytogenetically Normal Aml, Dimitrios Papaioannou, Geoffrey L. Uy, Et Al.

Open Access Publications

No abstract provided.

Gene-By-Gene Interactions Associated With The Risk Of Conotruncal Heart Defects, Chen Lyu, Daniel M Webber, Stewart L Macleod, Charlotte A Hobbs, Ming Li, National Birth Defects Prevention Study

Open Access Publications

BACKGROUND: The development of conotruncal heart defects (CTDs) involves a complex relationship among genetic variants and maternal lifestyle factors. In this article, we focused on the interactions between 13 candidate genes within folate, homocysteine, and transsulfuration pathways for potential association with CTD risk.

METHODS: Targeted sequencing was used for 328 case-parental triads enrolled in the National Birth Defects Prevention Study (NBDPS). To evaluate the interaction of two genes, we applied a conditional logistic regression model for all possible SNP pairs within two respective genes by contrasting the affected infants with their pseudo-controls. The findings were replicated in an independent sample …

Integrative Analysis Identifies Candidate Tumor Microenvironment And Intracellular Signaling Pathways That Define Tumor Heterogeneity In Nf1, Jineta Banerjee, Robert J Allaway, Jaclyn N Taroni, Aaron Baker, Xiaochun Zhang, Chang In Moon, Christine A Pratilas, Jaishri O Blakeley, Justin Guinney, Angela Hirbe, Casey S Greene, Sara Jc Gosline

Open Access Publications

Neurofibromatosis type 1 (NF1) is a monogenic syndrome that gives rise to numerous symptoms including cognitive impairment, skeletal abnormalities, and growth of benign nerve sheath tumors. Nearly all NF1 patients develop cutaneous neurofibromas (cNFs), which occur on the skin surface, whereas 40-60% of patients develop plexiform neurofibromas (pNFs), which are deeply embedded in the peripheral nerves. Patients with pNFs have a ~10% lifetime chance of these tumors becoming malignant peripheral nerve sheath tumors (MPNSTs). These tumors have a severe prognosis and few treatment options other than surgery. Given the lack of therapeutic options available to patients with these tumors, identification …

Use Of Neuroimaging To Inform Optimal Neurocognitive Criteria For Detecting Hiv-Associated Brain Abnormalities, Laura M Campbell, David B Clifford, Et Al, Charter Group

Open Access Publications

OBJECTIVE: Frascati international research criteria for HIV-associated neurocognitive disorders (HAND) are controversial; some investigators have argued that Frascati criteria are too liberal, resulting in a high false positive rate. Meyer et al. recommended more conservative revisions to HAND criteria, including exploring other commonly used methodologies for neurocognitive impairment (NCI) in HIV including the global deficit score (GDS). This study compares NCI classifications by Frascati, Meyer, and GDS methods, in relation to neuroimaging markers of brain integrity in HIV.

METHOD: Two hundred forty-one people living with HIV (PLWH) without current substance use disorder or severe (confounding) comorbid conditions underwent comprehensive neurocognitive …

Professional Decision-Making In Medicine: Development Of A New Measure And Preliminary Evidence Of Validity, Alison L. Antes, Kelly K. Dineen, Erin Bakanas, Tyler Zahrli, Jason D. Keune, Matthew J. Schuelke, James M. Dubois

Open Access Publications

INTRODUCTION: This study developed a new Professional Decision-Making in Medicine Measure that assesses the use of effective decision-making strategies: seek help, manage emotions, recognize consequences and rules, and test assumptions and motives. The aim was to develop a content valid measure and obtain initial evidence for construct validity so that the measure could be used in future research or educational assessment.

METHODS: Clinical scenario-based items were developed based on a review of the literature and interviews with physicians. For each item, respondents are tasked with selecting two responses (out of six plausible options) that they would choose in that situation. …

Insulin Resistance Drives Hepatic De Novo Lipogenesis In Nonalcoholic Fatty Liver Disease, Gordon I Smith, Mahalakshmi Shankaran, Mihoko Yoshino, George G Schweitzer, Maria Chondronikola, Joseph W Beals, Adewole L Okunade, Bruce W Patterson, Edna Nyangau, Tyler Field, Claude B Sirlin, Saswata Talukdar, Marc K Hellerstein, Samuel Klein

Open Access Publications

BACKGROUNDAn increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in individuals with NAFLD. The physiological factors that stimulate hepatic DNL and the effect of weight loss on hepatic DNL are not clear.METHODSHepatic DNL, 24-hour integrated plasma insulin and glucose concentrations, and both liver and whole-body insulin sensitivity were determined in individuals who were lean (n = 14), obese with normal IHTG content (n = 26), or obese with NAFLD (n = 27). Hepatic DNL was assessed using the deuterated …

Human Brain Functional Network Organization Is Disrupted After Whole-Brain Radiation Therapy, Timothy J. Mitchell, Benjamin A. Seitzman, Nicholas Ballard, Steven E. Petersen, Joshua S. Shimony, Eric C. Leuthardt

Open Access Publications

No abstract provided.

Real-Time Colorectal Cancer Diagnosis Using Pr-Oct With Deep Learning, Yifeng Zeng, Shiqi Xu, William C. Chapman Jr., Shuying Li, Zahra Alipour, Heba Abdelal, Deyali Chatterjee, Matthew Mutch, Quing Zhu

Open Access Publications

No abstract provided.

Intracranial Glioma Xenograft Model Rapidly Reestablishes Blood–Brain Barrier Integrity For Longitudinal Imaging Of Tumor Progression Using Fluorescence Molecular Tomography And Contrast Agents, Lemoyne Habimana-Griffin, Dezhuang Ye, Julia Carpenter, Julie Prior, Gail Sudlow, Lynne Marsala, Matthew Mixdorf, Joshua B. Rubin, Hong Chen, Samuel Achilefu

Open Access Publications

No abstract provided.

Strong Concordance Between Rna Structural And Single Nucleotide Variants Identified Via Next Generation Sequencing Techniques In Primary Pediatric Leukemia And Patient-Derived Xenograft Samples, Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey

Open Access Publications

No abstract provided.

Wikidata As A Knowledge Graph For The Life Sciences, Andra Waagmeester, Malachi Griffith, Obi L. Griffith, Et Al.

Open Access Publications

No abstract provided.

Metabolic And Addiction Indices In Patients On Opioid Agonist Medication-Assisted Treatment: A Comparison Of Buprenorphine And Methadone, Igor Elman, Margaret Howard, Jacob T. Borodovsky, David Mysels, David Rott, David Borsook, Mark Albanese

Open Access Publications

No abstract provided.

Anti-Angiogenic Effects Of Vegf Stimulation On Endothelium Deficient In Phosphoinositide Recycling, Amber N. Stratman, Olivia M. Farrelly, Constantinos M. Mikelis, Mayumi F. Miller, Zhiyong Wang, Van N. Pham, Andrew E. Davis, Margaret C. Burns, Sofia A. Pezoa, Daniel Castranova, Joseph J. Yano, Tina M. Kilts, George E. Davis, J. Silvio Gutkind, Brant M. Weinstein

Open Access Publications

No abstract provided.

Activity-Dependent Isomerization Of Kv4.2 By Pin1 Regulates Cognitive Flexibility, Jia-Hua Hu, Cole Malloy, G. Travis Tabor, Jakob J. Gutzmann, Ying Liu, Daniel Abebe, Rose-Marie Karlsson, Stewart Durell, Heather A. Cameron, Dax A. Hoffman

Open Access Publications

No abstract provided.

Exploration Of Sensory And Spinal Neurons Expressing Gastrin-Releasing Peptide In Itch And Pain Related Behaviors, Devin M. Barry, Xue-Ting Liu, Benlong Liu, Xian-Yu Liu, Fang Gao, Xiansi Zeng, Juan Liu, Qianyi Yang, Steven Wilhelm, Jun Yin, Ailin Tao, Zhou-Feng Chen

Open Access Publications

No abstract provided.

Redox Systems Biology: Harnessing The Sentinels Of The Cysteine Redoxome, Jason M. Held

Open Access Publications

No abstract provided.

Investigating The Effect Of Thyroid Nodule Location On The Risk Of Thyroid Cancer, Sina Jasim, Thomas J. Baranski, Sharlene A. Teefey, William D. Middleton

Open Access Publications

No abstract provided.

Identification Of The Growth Factor-Binding Sequence In The Extracellular Matrix Protein Magp-1, Thomas J. Broekelmann, Nicholas K. Bodmer, Robert P. Mecham

Open Access Publications

No abstract provided.

Monitoring The Itinerary Of Lysosomal Cholesterol In Niemann-Pick Type C1-Deficient Cells After Cyclodextrin Treatment, Mckenna Feltes, Sarah E. Gale, Samantha Moores, Daniel S. Ory, Jean E. Schaffer

Open Access Publications

No abstract provided.

Movement Pattern Training Compared With Standard Strengthening And Flexibility Among Patients With Hip-Related Groin Pain: Results Of A Pilot Multicentre Randomised Clinical Trial, Marcie Harris-Hayes, Karen Steger-May, Allyn M. Bove, Stefanie N. Foster, Michael J. Mueller, John C. Clohisy, G. Kelley Fitzgerald

Open Access Publications

No abstract provided.

Environmental Remodeling Of Human Gut Microbiota And Antibiotic Resistome In Livestock Farms, Jian Sun, Alaric W. D'Souza, Manish Boolchandani, Gautam Dantas, Et Al.

Open Access Publications

No abstract provided.

Reporting Guidelines, Review Of Methodological Standards, And Challenges Toward Harmonization In Bone Marrow Adiposity Research. Report Of The Methodologies Working Group Of The International Bone Marrow Adiposity Society, Josefine Tratwal, Erica L Scheller, Et Al

Open Access Publications

The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer) as well as treatments (corticosteroid, radiation, chemotherapy, thiazolidinediones). However, to advance the field of BMA research, standardization of methods is desirable to increase comparability of study outcomes and foster collaboration. Therefore, at the 2017 annual BMA meeting, the International Bone Marrow Adiposity Society (BMAS) founded a working group to evaluate methodologies in BMA research. All BMAS members could volunteer to participate. The working group members, who are all active preclinical …

Self-Perception Of Physical Function Contributes To Participation In Cognitively- And Physically-Demanding Activities After Stroke, Marjorie L Nicholas, Kari Burch, Julianne R Mitchell, Annie B Fox, Carolyn M Baum, Lisa Tabor Connor

Open Access Publications

No abstract provided.

Targeting Unconventional Host Components For Vaccination-Induced Protection Against Tb, Elisa Nemes, Shabaana A Khader, Rosemary V Swanson, Willem A Hanekom

Open Access Publications

The current tuberculosis (TB) vaccine, Bacille Calmette-Guerin (BCG), is effective in preventing TB in young children but was developed without a basic understanding of human immunology. Most modern TB vaccine candidates have targeted CD4

Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived Β Cells, Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Jeffrey R Millman

Open Access Publications

Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are likely to represent an early clinical translation of differentiated human pluripotent stem cells (hPSC). In 2014, two groups generated the first

Mitofusin 2 Dysfunction And Disease In Mice And Men, Gerald W Dorn Ii

Open Access Publications

A causal relationship between Mitofusin (MFN) 2 gene mutations and the hereditary axonal neuropathy Charcot-Marie-Tooth disease type 2A (CMT2A) was described over 15 years ago. During the intervening period much has been learned about MFN2 functioning in mitochondrial fusion, calcium signaling, and quality control, and the consequences of these MFN2 activities on cell metabolism, fitness, and development. Nevertheless, the challenge of defining the central underlying mechanism(s) linking mitochondrial abnormalities to progressive dying-back of peripheral arm and leg nerves in CMT2A is largely unmet. Here, a different perspective of why, in humans, MFN2 dysfunction preferentially impacts peripheral nerves is provided based …

Global Proteomics Analysis Of Circulating Extracellular Vesicles Isolated From Lung Transplant Recipients, Sandhya Bansal, Marissa Mcgilvrey, Krystine Garcia-Mansfield, Ritin Sharma, Ross M. Bremner, Michael A. Smith, Ramsey Hachem, Patrick Pirrotte, Thalachallour Mohanakumar

Open Access Publications

No abstract provided.

Dna Double-Strand Breaks Induce H2ax Phosphorylation Domains In A Contact-Dependent Manner, Patrick L. Collins, Caitlin Purman, Sofia I. Porter, Vincent Nganga, Ankita Saini, Katharina E. Hayer, Greer L. Gurewitz, Barry P. Sleckman, Jeffrey J. Bednarski, Craig H. Bassing, Eugene M. Oltz

Open Access Publications

No abstract provided.

Hippocampal Volume In Provisional Tic Disorder Predicts Tic Severity At 12-Month Follow-Up, Soyoung Kim, Deanna J Greene, Carolina Badke D'Andrea, Emily C Bihun, Jonathan M Koller, Bridget O'Reilly, Bradley L Schlaggar, Kevin J Black

Open Access Publications

Previous studies have investigated differences in the volumes of subcortical structures (e.g., caudate nucleus, putamen, thalamus, amygdala, and hippocampus) between individuals with and without Tourette syndrome (TS), as well as the relationships between these volumes and tic symptom severity. These volumes may also predict clinical outcome in Provisional Tic Disorder (PTD), but that hypothesis has never been tested. This study aimed to examine whether the volumes of subcortical structures measured shortly after tic onset can predict tic symptom severity at one-year post-tic onset, when TS can first be diagnosed. We obtained T1-weighted structural MRI scans from 41 children with PTD …

Depletion Interactions Modulate The Binding Between Disordered Proteins In Crowded Environments, Franziska Zosel, Andrea Soranno, Karin J. Buholzer, Daniel Nettels, Benjamin Schuler

Open Access Publications

No abstract provided.