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Articles 3421 - 3450 of 4253
Full-Text Articles in Entire DC Network
Xenotransplantation Of Embryonic Pig Kidney Or Pancreas To Replace The Function Of Mature Organs, Marc R. Hammerman
Xenotransplantation Of Embryonic Pig Kidney Or Pancreas To Replace The Function Of Mature Organs, Marc R. Hammerman
Open Access Publications
No abstract provided.
The Development And Characterization Of A 60k Snp Chip For Chicken, Martin Am Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C. Warren, Ladeana W. Hillier, Richard Pma Crooijmans, Addie Vereijken, Ron Okimoto, Williams M. Muir, Hans H. Cheng
The Development And Characterization Of A 60k Snp Chip For Chicken, Martin Am Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C. Warren, Ladeana W. Hillier, Richard Pma Crooijmans, Addie Vereijken, Ron Okimoto, Williams M. Muir, Hans H. Cheng
Open Access Publications
No abstract provided.
Lineage-Specific Evolution Of The Vertebrate Otopetrin Gene Family Revealed By Comparative Genomic Analyses, Belen Hurle, Tomas Marques-Bonet, Francesca Antonacci, Inna Hughes, Joseph F. Ryan, Nisc Comparative Sequencing Program, Evan E. Eichler, David M. Ornitz, Eric D. Green
Lineage-Specific Evolution Of The Vertebrate Otopetrin Gene Family Revealed By Comparative Genomic Analyses, Belen Hurle, Tomas Marques-Bonet, Francesca Antonacci, Inna Hughes, Joseph F. Ryan, Nisc Comparative Sequencing Program, Evan E. Eichler, David M. Ornitz, Eric D. Green
Open Access Publications
No abstract provided.
Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng
Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng
Open Access Publications
No abstract provided.
Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue
Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue
Open Access Publications
Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in rheumatoid arthritis, where they serve as a diagnostic indicator. We show here that processing of the protein hen egg-white lysozyme (HEL) resulted in citrullination of peptides presented on class II MHC molecules by antigen-presenting cells. The presentation of the citrullinated peptides but not of the unmodified peptides was associated with autophagy. Dendritic cells (DCs), macrophages, and thymic DCs presented citrullinated peptides constitutively. Their treatment with 3-methyladenine (3MA) blocked presentation of citrullinated HEL peptides, but presentation of unmodified peptides was not affected. Presentation of citrullinated peptides was not detected on …
Type I Interferon Is Selectively Required By Dendritic Cells For Immune Rejection Of Tumors, Mark S. Diamond, Michelle Kinder, Hirokazu Matsushita, Mona Mashayekhi, Gavin P. Dunn, Jessica M. Archambault, Hsiaoju Lee, Cora D. Arthur, J Michael White, Ulrich Kalinke, Kenneth M. Murphy, Robert D. Schreiber
Type I Interferon Is Selectively Required By Dendritic Cells For Immune Rejection Of Tumors, Mark S. Diamond, Michelle Kinder, Hirokazu Matsushita, Mona Mashayekhi, Gavin P. Dunn, Jessica M. Archambault, Hsiaoju Lee, Cora D. Arthur, J Michael White, Ulrich Kalinke, Kenneth M. Murphy, Robert D. Schreiber
Open Access Publications
Cancer immunoediting is the process whereby the immune system suppresses neoplastic growth and shapes tumor immunogenicity. We previously reported that type I interferon (IFN-α/β) plays a central role in this process and that hematopoietic cells represent critical targets of type I IFN's actions. However, the specific cells affected by IFN-α/β and the functional processes that type I IFN induces remain undefined. Herein, we show that type I IFN is required to initiate the antitumor response and that its actions are temporally distinct from IFN-γ during cancer immunoediting. Using mixed bone marrow chimeric mice, we demonstrate that type I IFN sensitivity …
Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick
Cd103+ Pulmonary Dendritic Cells Preferentially Acquire And Present Apoptotic Cell-Associated Antigen, A Nicole Desch, Gwendalyn J. Randolph, Kenneth Murphy, Emmanuel L. Gautier, Ross M. Kedl, Mireille H. Lahoud, Irina Caminschi, Ken Shortman, Peter M. Henson, Claudia V. Jakubzick
Open Access Publications
Cells undergoing programmed cell death (apoptosis) are removed in situ by macrophages and dendritic cells (DCs) through a specialized form of phagocytosis (efferocytosis). In the lung, there are two primary DC subsets with the potential to migrate to the local lymph nodes (LNs) and initiate adaptive immune responses. In this study, we show that only CD103(+) DCs were able to acquire and transport apoptotic cells to the draining LNs and cross present apoptotic cell-associated antigen to CD8 T cells. In contrast, both the CD11b(hi) and the CD103(+) DCs were able to ingest and traffic latex beads or soluble antigen. CD103(+) …
Innate And Cytokine-Driven Signals, Rather Than Microbial Antigens, Dominate In Natural Killer T Cell Activation During Microbial Infection, Manfred Brigl, Raju V.V. Tatituri, Gerald F.M. Watts, Veemal Bhowruth, Elizabeth A. Leadbetter, Nathaniel Barton, Nadia R. Cohen, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner
Innate And Cytokine-Driven Signals, Rather Than Microbial Antigens, Dominate In Natural Killer T Cell Activation During Microbial Infection, Manfred Brigl, Raju V.V. Tatituri, Gerald F.M. Watts, Veemal Bhowruth, Elizabeth A. Leadbetter, Nathaniel Barton, Nadia R. Cohen, Fong-Fu Hsu, Gurdyal S. Besra, Michael B. Brenner
Open Access Publications
Invariant natural killer T cells (iNKT cells) are critical for host defense against a variety of microbial pathogens. However, the central question of how iNKT cells are activated by microbes has not been fully explained. The example of adaptive MHC-restricted T cells, studies using synthetic pharmacological α-galactosylceramides, and the recent discovery of microbial iNKT cell ligands have all suggested that recognition of foreign lipid antigens is the main driver for iNKT cell activation during infection. However, when we compared the role of microbial antigens versus innate cytokine-driven mechanisms, we found that iNKT cell interferon-γ production after in vitro stimulation or …
Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler
Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler
Open Access Publications
Deficits in mitochondrial function result in many human diseases. The X-linked disease Barth syndrome (BTHS) is caused by mutations in the tafazzin gene TAZ1. Its product, Taz1p, participates in the metabolism of cardiolipin, the signature phospholipid of mitochondria. In this paper, a yeast BTHS mutant tafazzin panel is established, and 18 of the 21 tested BTHS missense mutations cannot functionally replace endogenous tafazzin. Four BTHS mutant tafazzins expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting misfolding of the mutant polypeptides. Paradoxically, each of these mutant tafazzins assembles in normal protein complexes. Furthermore, in the …
Genome-Wide Identification And Quantification Of Cis- And Trans-Regulated Genes Responding To Marek’S Disease Virus Infection Via Analysis Of Allele-Specific Expression, Sean Maceachern, William M. Muir, Seth D. Crosby, Hans H. Cheng
Genome-Wide Identification And Quantification Of Cis- And Trans-Regulated Genes Responding To Marek’S Disease Virus Infection Via Analysis Of Allele-Specific Expression, Sean Maceachern, William M. Muir, Seth D. Crosby, Hans H. Cheng
Open Access Publications
No abstract provided.
The Tumor Suppressor Gene Trp53 Protects The Mouse Lens Against Posterior Subcapsular Cataracts And The Bmp Receptor Acvr1 Acts As A Tumor Suppressor In The Lens, Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe
The Tumor Suppressor Gene Trp53 Protects The Mouse Lens Against Posterior Subcapsular Cataracts And The Bmp Receptor Acvr1 Acts As A Tumor Suppressor In The Lens, Luke A. Wiley, Ramya Rajagopal, Lisa K. Dattilo, David C. Beebe
Open Access Publications
No abstract provided.
Effect Of Supplementation During Pregnancy With L-Arginine And Antioxidant Vitamins In Medicalfood On Pre-Eclampsia In High Risk Population: Randomised Controlled Trial, Felipe Vadillo-Ortega, Otilia Perichant-Perera, Salvador Espino, Marco Antonio Avila-Vergara, Isabel Ibarra, Roberto Ahued, Myrna Godines, Samuel Parry, George Macones, Jerome F. Strauss
Effect Of Supplementation During Pregnancy With L-Arginine And Antioxidant Vitamins In Medicalfood On Pre-Eclampsia In High Risk Population: Randomised Controlled Trial, Felipe Vadillo-Ortega, Otilia Perichant-Perera, Salvador Espino, Marco Antonio Avila-Vergara, Isabel Ibarra, Roberto Ahued, Myrna Godines, Samuel Parry, George Macones, Jerome F. Strauss
Open Access Publications
No abstract provided.
Bcl3 Prevents Acute Inflammatory Lung Injury In Mice By Restraining Emergency Granulopoiesis, Daniel Kreisel, Seiichiro Sugimoto, Jeremy Tietjens, Jihong Zhu, Sumiharu Yamamoto, Alexander S. Krupnick, Ruaidhri J. Carmody, Andrew E. Gelman
Bcl3 Prevents Acute Inflammatory Lung Injury In Mice By Restraining Emergency Granulopoiesis, Daniel Kreisel, Seiichiro Sugimoto, Jeremy Tietjens, Jihong Zhu, Sumiharu Yamamoto, Alexander S. Krupnick, Ruaidhri J. Carmody, Andrew E. Gelman
Open Access Publications
No abstract provided.
Rna Sensor-Induced Type I Ifn Prevents Diabetes Caused By A Β Cell-Tropic Virus In Mice, Stephen A. Mccartney, William Vermi, Silvia Lonardi, Cristina Rossini, Karel Otero, Boris Calderon, Susan Gilfillan, Michael S. Diamond, Emil R. Unanue, Marco Colonna
Rna Sensor-Induced Type I Ifn Prevents Diabetes Caused By A Β Cell-Tropic Virus In Mice, Stephen A. Mccartney, William Vermi, Silvia Lonardi, Cristina Rossini, Karel Otero, Boris Calderon, Susan Gilfillan, Michael S. Diamond, Emil R. Unanue, Marco Colonna
Open Access Publications
No abstract provided.
Notch1 Loss Of Heterozygosity Causes Vascular Tumors And Lethal Hemorrhage In Mice, Zhenyi Liu, Ahu Turkoz, Erin N. Jackson, Joseph C. Corbo, John A. Engelbach, Joel R. Garbow, David R. Piwnica-Worms, Raphael Kopan
Notch1 Loss Of Heterozygosity Causes Vascular Tumors And Lethal Hemorrhage In Mice, Zhenyi Liu, Ahu Turkoz, Erin N. Jackson, Joseph C. Corbo, John A. Engelbach, Joel R. Garbow, David R. Piwnica-Worms, Raphael Kopan
Open Access Publications
No abstract provided.
Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al.
Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al.
Open Access Publications
No abstract provided.
Rhoa Protects The Mouse Heart Against Ischemia/Reperfusion Injury, Sunny Yang Xiang, Davy Vanhoutte, Dominic P. Del Re, Nicole H. Purcell, Haiyun Ling, Indroneal Banerjee, Julie Bossuyt, Richard A. Lang, Yi Zheng, Scot J. Matkovich, Shigeki Miyamoto, Jeffrey D. Molkentin, Gerald W. Dorn Ii, Joan Heller Brown
Rhoa Protects The Mouse Heart Against Ischemia/Reperfusion Injury, Sunny Yang Xiang, Davy Vanhoutte, Dominic P. Del Re, Nicole H. Purcell, Haiyun Ling, Indroneal Banerjee, Julie Bossuyt, Richard A. Lang, Yi Zheng, Scot J. Matkovich, Shigeki Miyamoto, Jeffrey D. Molkentin, Gerald W. Dorn Ii, Joan Heller Brown
Open Access Publications
No abstract provided.
Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al.
Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al.
Open Access Publications
No abstract provided.
Arhgap24 Inactivates Rac1 In Mouse Podocytes, And A Mutant Form Is Associated With Familial Focal Segmental Glomerulosclerosis, Shreeram Akilesh, Hani Suleiman, Christine Stander, Haiyang Yu, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollack, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw
Arhgap24 Inactivates Rac1 In Mouse Podocytes, And A Mutant Form Is Associated With Familial Focal Segmental Glomerulosclerosis, Shreeram Akilesh, Hani Suleiman, Christine Stander, Haiyang Yu, Peter Lavin, Rasheed Gbadegesin, Corinne Antignac, Martin Pollack, Jeffrey B. Kopp, Michelle P. Winn, Andrey S. Shaw
Open Access Publications
No abstract provided.
Pml-Rara Can Increase Hematopoietic Self-Renewal Without Causing A Myeloproliferative Disease In Mice, John S. Welch, Wenlin Yuan, Timothy J. Ley
Pml-Rara Can Increase Hematopoietic Self-Renewal Without Causing A Myeloproliferative Disease In Mice, John S. Welch, Wenlin Yuan, Timothy J. Ley
Open Access Publications
No abstract provided.
Dna Repair And Synthetic Lethality, Gong-She Guo, Feng-Mei Zhang, Rui-Jie Gao, Robert Delsite, Zhi-Hui Feng, Simon N. Powell
Dna Repair And Synthetic Lethality, Gong-She Guo, Feng-Mei Zhang, Rui-Jie Gao, Robert Delsite, Zhi-Hui Feng, Simon N. Powell
Open Access Publications
No abstract provided.
Micrornas, An Active And Versatile Group In Cancers, Jeffrey Liu, Min Zheng, Ya-Ling Tang, Xin-Hua Liang, Qin Yang
Micrornas, An Active And Versatile Group In Cancers, Jeffrey Liu, Min Zheng, Ya-Ling Tang, Xin-Hua Liang, Qin Yang
Open Access Publications
No abstract provided.
Targeting Htlv-1 Activation Of Nfκb In Mouse Models And Atll Patients, Daniel A. Rauch, Lee Ratner
Targeting Htlv-1 Activation Of Nfκb In Mouse Models And Atll Patients, Daniel A. Rauch, Lee Ratner
Open Access Publications
No abstract provided.
Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green
Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green
Open Access Publications
No abstract provided.
Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal
Role Of Nadph Oxidase Versus Neutrophil Proteases In Antimicrobial Host Defense, R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal
Open Access Publications
No abstract provided.
In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva
In-Depth Analysis Of The Antibody Response Of Individuals Exposed To Primary Dengue Virus Infection, Ruklanthi De Alwis, Martina Beltramello, William B. Messer, Soila Sukupolvi-Petty, Wahala M. P. B. Wahala, Annette Kraus, Nicholas P. Olivarez, Quang Pham, James Brian, Wen-Yang Tsai, Wei-Kung Wang, Scott Halstead, Srisakul Kliks, Michael S. Diamond, Ralph Baric, Antonio Lanzavecchia, Federica Sallusto, Aravinda M. De Silva
Open Access Publications
No abstract provided.
Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang
Astrovirus Mlb1 Is Not Associated With Diarrhea In A Cohort Of Indian Children, Lori R. Holtz, Irma K. Bauer, Priya Rajendran, Gagandeep Kang, David Wang
Open Access Publications
No abstract provided.
Glucose And Fatty Acids Synergize To Promote B-Cell Apoptosis Through Activation Of Glycogen Synthase Kinase 3beta Independent Of Jnk Activation, Katsuya Tanabe, Yang Liu, Syed D. Hasan, Sara C. Martinez, Corentin Cras-Meneur, Cris M. Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J. Rhodes, Erik Zmuda, Tsonwin Hai, Nada A. Abumrad, M. Alan Permutt
Glucose And Fatty Acids Synergize To Promote B-Cell Apoptosis Through Activation Of Glycogen Synthase Kinase 3beta Independent Of Jnk Activation, Katsuya Tanabe, Yang Liu, Syed D. Hasan, Sara C. Martinez, Corentin Cras-Meneur, Cris M. Welling, Ernesto Bernal-Mizrachi, Yukio Tanizawa, Christopher J. Rhodes, Erik Zmuda, Tsonwin Hai, Nada A. Abumrad, M. Alan Permutt
Open Access Publications
No abstract provided.
Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock
Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock
Open Access Publications
No abstract provided.
Binocular Disparity Tuning And Visual–Vestibular Congruency Of Multisensory Neurons In Macaque Parietal Cortex, Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. Deangelis, Dora E. Angelaki
Binocular Disparity Tuning And Visual–Vestibular Congruency Of Multisensory Neurons In Macaque Parietal Cortex, Yun Yang, Sheng Liu, Syed A. Chowdhury, Gregory C. Deangelis, Dora E. Angelaki
Open Access Publications
No abstract provided.