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Preventive Health Care Among Immigrant Sudanese Women In The Greater Hartford Area Of Connecticut, Fawatih Y. Mohamed-Abouh

Master's Theses

No abstract provided.

The Effects Of Nicotine On Conditioning, Extinction, And Reinstatement In Humans Using A Virtual Reality Conditioned Place Preference Paradigm, Alexandra N. Palmisano

Master's Theses

Despite an abundance of evidence illustrating the harmful effects of nicotine use, only a small percentage of users successfully quit (Messer et al., 2008). Moreover, current treatments for nicotine cessation produce only a slight increase in the likelihood of successfully quitting, which emphasizes the need for more effective strategies that facilitate smoking cessation (Hopkins et al., 2001). Several studies suggest that difficulty in controlling nicotine use behaviors results from nicotine’s ability to enhance the motivating function of cues associated with obtaining rewards. These studies indicate that it is of value to understand the behavioral and neuropharmacological mechanisms by which nicotine …

Assessment Of Micronutrient Status In Pregnant Malawian Women Before And After Treatment For Moderate Malnutrition, Cambria M. Glosz

Master's Theses

Background: Multiple micronutrient deficiencies are prevalent in pregnant women in developing countries and can result in adverse effects to both the mother and infant. Multiple micronutrient supplements or supplementary foods may be a way to combat micronutrient deficiencies.

Objective: To assess change in micronutrient and protein levels in moderately malnourished pregnant Malawian women after receiving one of three nutritional interventions.

Methods: Serum retinol, 25-hydroxyvitamin D, ferritin, vitamin B₁₂, folate, zinc, albumin and C-reactive protein concentrations were measured in pregnant women with MUAC >20.6 cm and

Results: Baseline micronutrient concentrations indicated high rates of deficiency …

Internalized Stigma Among Hiv-Positive Men On Antiretroviral Therapy In Urban India, Mitchell L. Irving

Master's Theses

No abstract provided.

Physicians’ Perceived Roles In And Barriers To Identifying, Evaluating, And Managing Intimate Partner Violence, Adam F. Pennarola

Master's Theses

No abstract provided.

Long-Term Feeding Ecology Of Early-Stage Striped Bass (Morone Saxatilis) And American Shad (Alosa Sapidissima) In The Hudson River Estuary, Michael G. Smircich

Master's Theses

No abstract provided.

Fluid Flow Characterization In Rapid Prototyped Common Iliac Artery Aneurysm Molds, Daniel Cole Greinke

Master's Theses

The goal of this project was to determine whether i) fused deposition modeling could be employed to manufacture molds for vascular constructs, ii) whether vascular constructs could be created from these molds, and iii) to verify practical equivalence between observed fluid velocities. Dye tracking was to be employed to characterize fluid velocity profiles through the in vitro vascular constructs, including a half-vessel model and a full vessel model of an iliac artery aneurysm. A PDMS half-vessel construct was manufactured, and the movement of dye through the construct was tracked by a cellphone camera. Thresholds were applied to each video in …

Predicting Suitable Habitat Decline Of Midwestern United States Amphibians And Quantifying The Consequence Of Declines Using Pond-Breeding Salamanders, Brock Struecker

Master's Theses

With current declines of vertebrate taxa meeting or exceeding those of historic mass extinction events, there is a growing need to investigate the main drivers of declines. Amphibians are perhaps at greatest risk of global climate change and land-use changes than most other vertebrate classes and also have significant roles in ecosystem processes – combined, this creates a cause for concern. I designed a study that would investigate the effects of current and predicted climate change and land-use changes on amphibians using species distribution models and a field study to identify the potential consequences of amphibian species declines by investigating …

A Study Of Immune-Regulation Of Microbiota Supernatant On Macrophage Function, An N. Nguyen

Master's Theses

The diverse human microbial ecosystem colonizes many different body sites. The gastrointestinal (GI) tract, especially, is a major region that that harbors a complex microbial community composed of trillions of commensal bacteria. Interactions between the commensal bacteria and the host immune system begin at birth and continue through the human lifespan. In the gut, commensal bacteria help the host to ensure the maintenance of intestinal homeostasis as well as the mucosal barrier structure through host stimulation of mucus and antimicrobial molecules. The secretion of these host factors functions to inhibit pathogenic invasion and maintain the population of commensal bacteria. The …

Characterization Of Il-22-Producing Cells In The Human Thymus And The Mechanism By Which Il-22 Expression Is Modulated By Thymic Epithelial Cells., Nadine N. Morgan

Master's Theses

Thymic epithelial cells (TECs) are indispensable for T cell development and maturation. Therefore, damages to the thymic epithelial cells are detrimental to thymic function and immune response. In young healthy individuals, TECs have a high regenerative potential and are capable of renewal from serious damage; however, the molecular mechanism of this recovery is unclear. A recent study has shown that IL-22-producing ILCs are present in the mouse thymus and can regenerate thymic epithelial cells following radiation induced injuries. However, it is unknown whether IL-22-producing cells are also found in the human thymus. Thus, the goal of this study is to …

Defining The Role Of A Putative Peptidase In Staphylococcus Aureus Quorum Sensing And Pathogenesis, Chelsea Rose White

Master's Theses

The pathogenic bacterium Staphylococcus aureus encounters a variety of immune cells that restrict bacterial growth and dissemination during infection. However, S. aureus counters these immune cell functions by producing myriad virulence factors that facilitate evasion of host defenses. Therefore, it is important to understand S. aureus-immune cell interactions and the virulence factors that perturb normal immune function to promote pathogenesis. In a genetic screen designed to identify S. aureus secreted factors that modulate macrophage activity our lab identified a transposon insertion mutant in the gene SAUSA300_1984, encoding a putative membrane spanning peptidase. To investigate the role of 1984 in pathogenesis, …

Europe’S Refugee Crisis: Assessing The Factors Preventing A Coordinated Eu Response, Ali Albassam

Master's Theses

In order to escape increasing political violence in the Middle East and Africa, many refugees are fleeing by sea to seek asylum in Europe. As a result, Europe has witnessed the highest influx of refugees since World War Two. European Union member states have scrambled for a solution, seemingly unable to form a collective response. The reemergence of nationalism amid the arrival of thousands of refugees not only clouds Europe’s moral compass, but also weakens the EU and its founding principles. In an effort to contribute to the protection of refugees and the EU and its values, this thesis aims …

Bioarchaeological Analysis Of Oak View Landing (40dr1): An Archaic Population In The Kentucky Lake Reservior, Katy D. Grant-Mclemore

Master's Theses

The biocultural examination of the Archaic population recovered at Oak View Landing (40DR1) investigates the lifeways and adaptations of prehistoric people as they reflect sociopolitical and subsistence strategies.

A comprehensive bioarchaeological analysis was conducted on the adult individuals (18 males, 16 females, 16 of indeterminate sex) excavated from a multiple occupation site located along the Tennessee River in Decatur County, Tennessee. Skeletal indicators used to understand biocultural phenomena were assessed macroscopically on cranial and postcranial elements. Furthermore, mortuary data, for adults and subadults, were used to determine any patterns of preferential treatment at death.

Results from this study indicate that …

Paleopathology At The Shady Grove Site (22qu525): A Study Of Health In The Upper Yazoo Basin During The Middle Mississippian Period, Christopher Brady Davis

Master's Theses

The Mississippian Period (AD 1000-1539) is characterized by increasingly sedentary populations, mound building, ranked societies, and intensified agriculture. As agriculture spread throughout the Eastern Woodlands, it led to widespread health consequences, including poor nutrition and increased levels of infection. Also, environmental shifts during the Mississippian Period (AD 1000-1539) caused drier conditions, potentially leading to crop failures further exacerbating nutritional problems.

This thesis focuses on the health of the Shady Grove site in the Upper Yazoo Basin, a Middle to Late Mississippian medium sized mound center where an ossuary containing up to 100 individuals was excavated in 2010. Focusing only on …

Predicting Invasive Range Of Eucalyptus Globulus In California, Anthony J. Lopez

Master's Theses

Eucalyptus globulus is the subject of intense debate in California. Its invasive potential, aggressive growth, reproductive biology, and association with fire make the prediction of spread important in California. Two modeling simulations, Climex and Maxent, will illustrate the distribution and potential growth range of E. globulus in California based on climate and presence. Modeling the potential range of growth will predict invasive spread. The anticipated result is the continued spread of E. globulus in coastal regions with adequate moisture and suitable climate. Predicting the range of E. globulus in California dictates management strategy and is key for preventing further introduction, …

Efficacy Of Plant-Derived Antimicrobials In Reducing Foodborne Pathogens In Agricultural Soil And Their Effect On Soil Nutrients And Microbiome, Samantha M. Fancher

Master's Theses

Bacterial pathogens, such as Salmonella and Listeria monocytogenes, can contaminate agricultural soil thereby increasing the risk of produce-associated foodborne outbreaks. In this study three plant-derived antimicrobials (PDAs), carvacrol (CR), thymol (TY), and β-resorcylic acid (BR) were analyzed for their efficacy in reducing Salmonella and L. monocytogenes in agricultural soil. The effect of the PDAs on the soil pH, nutrients, and microbiome was also determined.

Sandy loam soil was inoculated with either Salmonella or L. monocytogenes followed by the addition of 0.25 or 0.5% CR, TY, and BR. The treated samples were analyzed up to 21 days for surviving pathogens. …

Characterization Of Electrophorectic Separations On A Cellulose Paper-Microfluidic Chip, Kyle Robert Fast

Master's Theses

The purpose of this thesis project is to demonstrate the ability to utilize electrophoresis in a cellulose paper microfluidic chip to manipulate charged particles. Materials were selected and a manufacturing protocol was created to successfully apply the electric field onto the paper chip. Experiments were performed to characterize the separation rates for charged, colorimetric dye, Orange G in the membrane as a function of an applied electric field, dye concentration, and distance traveled. The experiments confirmed that the electric field can be applied to the chip and particle separation rates were characterized. Next, the determined rates results were used to …

Degradation And Removal Of Porphyromonas Gingivalis Lipid 654 By Common Endodontic Intracanal Irrigants And Medicaments, Michelle A. Hack

Master's Theses

No abstract provided.

Biofilm Accumulation And Immune Response During Experimental Peri-Implant Mucositis., Amy Rosania

Master's Theses

No abstract provided.

Public Diplomacy For A Global World: The United States And Iran, Sarah A. Aghazadeh

Master's Theses

Complex global challenges – including environmental, economic, diplomatic, and health-related – span national boundaries and increasingly necessitate international cooperation. As a result, diplomacy has broadened from government-to-government relations to include government-to-public relations in an extended constituency of the global whole. Public diplomacy is a process by which governments attempt to attract and persuade various external publics to maintain relationships and encourage an environment for the approval of policies. Examining globalization, diplomacy, and power provides the foundation to assess a specific case of US public diplomacy with Iran. Systems theory provides a focus on the critical interactions, feedback processes, and relationships …

Physiological Factors Affecting The Bactericidal Activity Of The Western Fence Lizard (Sceloporus Occidentalis) For The Lyme Disease Spirochete, Borrelia Burgdorferi, Kyle Russell Weichert

Master's Theses

The Western Fence Lizard (Sceloporus occidentalis) is a major host of juvenile stages of the Western Black-legged Tick (Ixodes pacificus), which is the vector for the Lyme disease causative spirochete bacterium Borrelia burgdorferi in the western United States. Because S. occidentalis is reservoir incompetent and capable of eliminating spirochetes from infected ticks, it has been implicated as a major factor in the ecology of Lyme disease in the West. Although complement proteins in lizard blood have been established as the borreliacidal factor, no studies have examined intraspecific variability in host lizard borreliacidal capacity. In Chapter 1 …

Investigations Of Thioether Generation For S-D-Ribosyl-L-Homocysteine Synthesis, Brendan Corcoran

Master's Theses

Creation of the thioether linkage is a fundamental step for the chemical preparation of the bacterial quorum sensing molecule S-D-ribosyl-L-homocysteine (SRH). Although previous preparations of SRH and its analogues have been reported in the literature, they employ assorted methods with varied results. Therefore, a reassessment of the methodology used for synthetic preparation of the thioether bond in SRH-like molecules is here considered. This work examines four methods of thioether generation following two mechanisms, bimolecular nucleophilic substitution (S_N2) and radical-initiated thiol-ene coupling, in an attempt to generate SRH in a more efficient and reproducible manner. Both mechanisms address …

Detection Of Hcmv Viral Il-10 (Vil-10) In Healthy Blood Donors, Vivian P. Young

Master's Theses

Human cytomegalovirus (HCMV) is widespread in the general population and can establish lifelong latency with expression of a limited subset of viral genes. The UL111A gene is expressed during both lytic and latent infection, and at least two protein isoforms are produced. During lytic infection, the full length transcript yields cmvIL-10, a potent immunosuppressive viral ortholog of human IL-10 (hIL-10). Alternative splicing of the UL111A transcript yields a truncated protein, LAcmvIL-10, which is expressed during both lytic and latent infection but with a limited range of immunosuppressive functions. The two viral cytokines, collectively termed viral IL-10 (vIL-10), are identical in …

Non-Ost Route Transition Interventions Among Injecting Drug Users In Kabul, Afghanistan: A Qualitative Feasibility Assessment Based On Institutional Stakeholders’ Views, William P. Tootle Jr

Master's Theses

An HIV epidemic threatens injecting drug users in Kabul, Afghanistan. Although opioid substitution therapy (OST) has been proven to reduce the spread of HIV and decrease injecting drug use in many parts of the world, including on a small scale in Afghanistan, political obstacles suggest that at this time it may not be a viable intervention there. In this thesis, therefore, I assess the feasibility of implementing an alternative to OST as an HIV-prevention strategy, namely, a non-OST route-transition intervention (RTI) designed to encourage and enable opiate users to switch from injecting to smoking (also called chasing). Based on semi-structured …

A Ten Year Retrospective Study Of Pediatric Pneumonia Cases In Haiti, Talia A. Savic

Master's Theses

No abstract provided.

“Un Pueblo Tan Dulce”: Diabetes, Depression, And Obesity Syndemics In Puerto Rico, Shir Lerman

Master's Theses

No abstract provided.

Seasonal Variation In Corticosterone, Stress Responses, And Physiology In The Northern Cardinal Cardinalis Cardinalis, Benjamin Matthew Duckworth

Master's Theses

Seasonal regulation of the adrenocortical response (e.g., ‘stress response’) appears to be ubiquitous in mid- to high-latitude vertebrates. Northern Cardinals (Cardinalis cardinalis) are a Temperate dwelling passerine of Tropical-descent with a wide species range (tropics to Northern Temperate zones). This species encounters a wide variety of environmental conditions and strong seasonality, however corticosterone (CORT, the main adrenal stress hormone) has not been studied with regards to changes in seasonal levels. I initially analyzed samples from cardinals collected between 2007-2011 from the Lake Thoreau Environmental Research and Educational Center (Hattiesburg, Mississippi, USA). The data suggested seasonal differences of CORT, with higher …

Improved Detection Of Gold Nanoparticle Labels For Paper-Based Analytics, Brian Taylor Daugherty

Master's Theses

Point-of-care diagnostic devices are well-suited, and typically designed, for remote and/or resource-limited environments. The obvious application is for healthcare in the developing world; however, other additional important uses exist, including for security (biothreat agent detection) and human health and research during future manned deep space exploration missions.

The objective of this thesis was to develop, and experimentally validate, techniques for improved quantified detection of labels used in lateral flow assays. Limits of detection were characterized for: (a) optical approaches, i.e., unaided eye, mobile electronic device camera images and microscope images with image analysis software developed through this thesis, and (b) …

Experimental Evolution Of Specialism In A Wild Virus, Alexander Kula

Master's Theses

A pathogen's ability to successfully replicate and persist within a new host population is fraught with obstacles. While an expanded host-range allows for a greater chance at successful replication, such generalists are typically outcompeted by species which have specialized and adapted host-specific features. Although the most ubiquitous species on earth, very few bacteria-infecting viral species (bacteriophages) with truly broad host-ranges have been identified; this is partially due to the fact that only a small fraction of bacteria (and thus likely hosts) are amenable to laboratory conditions. Nevertheless, the processes of expanding as well as narrowing host-range are not well understood …

Sustainable Chicago 2015: A Political Analysis, Zachary A. Brown

Master's Theses

Over the last decade, many of America's urban areas have developed "sustainability plans" focusing on the long-term viability of their communities. Although many local governments have concentrated on environmental issues, others have incorporated economic and social policies. A new subset of literature has emerged highlighting equity and social justice within the sustainability dialogue. Scholars and practitioners alike argue that true sustainability requires equal access to all three pillars of sustainability for all groups.

Through interviews with public and private actors, as well as content analysis of the plan, this study investigates the structure of the governance network responsible for the …