Digital Commons Network^™

Anti-Predator Behavior In Response To Conspecific Visual, Olfactory, And Damage Cues In Three-Spined Sticklebacks, Claire E. Vanmeter

Honors Theses

Predation is a major source of mortality for prey, which creates a selective pressure to avoid predators whenever possible. By using alarm cues produced by conspecifics, individuals can be alerted of nearby predators without coming into direct contact with them. However, whether individuals can distinguish between different conspecific cues or whether some cues might indicate a more severe predation threat than others is not known. Studied was the three-spined stickleback’s ability to distinguish between environmental cues by exposing conspecifics to four different treatments in a randomized order: 1) Control (control olfactory cues with an unexposed demonstrator), 2) Visual Only (control …

Differential Gene Expressions Patterns In Diabetes In Relation To Cognitive Declines Associated With Diabetes, Dylan Downs

Honors Theses

The chronic metabolic disorder classified as diabetes, is growing at an alarming rate in many countries all across the globe. Diabetes is characterized by an above average blood glucose measurement, due to insulin production and insulin response abnormalities within the body. This increase in blood glucose has detrimental effects on all physiological systems, commonly associated with organs such as the heart, kidneys, eyes, and nerves. One of the less understood and commonly disregarded side effects of diabetes is related to the cognitive declines associated with the disease. Cognitive declines associated with diabetes include memory loss, speech impairments, and decreased motor …

Improving Fertility While Synchronizing Estrus In Beef Heifers When Feeding Mga, Anisa Olavarria

Honors Theses

Melengestrol Acetate (MGA) is used to suppress estrus in cattle and is used to synchronize estrus. However, when fed to beef cattle during the absence of a corpus luteum, a transient progesterone producing organ after ovulation, the dominant follicle is unable to regress becoming persistent resulting in decreased fertility of the oocyte. In this study, two treatment protocols were designed to test if administering GnRH, a hormone used to induce ovulation resulting in the formation of a corpus luteum at the beginning of the MGA feeding will prevent fewer persistent follicles and improve the fertility of the ovulation immediately following …

Features Selection In Regression Models Using Variance-Based Sensitivity Analysis, Jakob Spiller

Honors Theses

Variance-based sensitivity analysis serves as a crucial tool for assessing the variability of inputs on the output of complex mathematical models. In this thesis, we study Sobol indices, a class of variance-based sensitivity analysis, to quantify the importance of each input variable on the overall variability of the model output. We initially discuss Sobol’s first and total order indices. This includes a brief demonstration through two examples: the Sobol G-function and a polynomial function each with six input variables. These examples serve to highlight the theoretical foundations and practical applications of Sobol’s indices in analyzing model sensitivities. Mainly, we apply …

The Pussification Of Man: Evangelical Pastor Mark Driscoll And The Construction Of An “Ideal” Evangelical Masculinity, Phillip E. Cicero

Honors Theses

Scandals involving evangelical churches seem to appear daily in the news. Whether the scandals involve a church leader engaging in bullying, sexual harassment, sexual abuse or something else there seems to be no end in sight. One might imagine that people would flee the churches where these leaders have or continue to serve. But, in general, they do not. A good question to ask is why. Why do people continue to follow someone who has been proven through their discourse that they are aggressive, sexist, and sometimes even violent?

To answer this question, this project focuses on the rhetoric utilized …

Behavioral Responses Of Two Color Morphs Of The Eastern Red-Backed Salamander (Plethodon Cinereus) To Novel Urban Environments, Amy Q. Friemoth

Honors Theses

Human modified landscapes can provide challenging new environments that can lead to rapid changes in species traits. In temperate forest ecosystems, salamanders play a critical role in forest floor dynamics, but populations are now faced with rapid habitat change, which can lead to local extinction events unless species can adapt behaviorally. The Eastern Red-backed Salamander, Plethodon cinereus, is the most common salamander species in the northeastern United States and can serve as a model species for examining the effects of anthropogenic change. Further, the Eastern Red-backed Salamander poses two common color morphs (striped and unstriped) that appear to differ in …

Hippo, Wnt, And Jnk Pathway Interactions In A Drosophila Colorectal Cancer Model, Michael K. Gruhot

Honors Theses

Colorectal cancer (CRC) will be the leading cause of cancer-related deaths for people under the age of 50 by 2030. Due to increased efforts to spread awareness for regular screenings, the five-year relative survival rate for those diagnosed with colon cancer is 64.4% (www.fightcolorectalcancer.org). Treatment for CRC consists primarily of the excision of the tumor paired with regular doses of chemotherapy and radiation therapy. These treatments cause systemic stress, damaging both cancerous and healthy cells alike. In order to create more efficient treatments, first, we must better understand the biology underlying changes in cells that lead to tumors in the …

Selective Evolution Of Lithium Ions By Shewanella Loihica, Gabrielle A. Kozurek

Honors Theses

The prevalent use of lithium-ion batteries in consumer electronics poses a significant sustainability challenge to both manufacturing and source availability over the next 50 years. There are several methods to extract lithium from salt water that are commercially available but require caustic reagents and environmental hazards. However, several lithium-resistant bacteria can precipitate or mineralize lithium ions into a reduced form of lithium that can be processed readily into a lithium source material for batteries. The goal of this project was to culture, characterize, and selectively evolve Shewanlla loihica using lithium-ion concentration changes both aerobically and anaerobically. This strain has published …

Development Of A Machine Learning-Based Program To Measure Cell Proliferation, Adam J. Jones

Honors Theses

Many tools have emerged to investigate the functioning of biological systems, especially when in contact with foreign substances. In vitro procedures are often used due to their cost effectiveness and suitability for high-throughput experiments. These procedures collect basic measurements, such as toxicity and biocompatibility, that provide insight into the compatibility and safety of a substance. In vitro toxicity tests are favored for their expediency, affordability, and consistent outcomes. Quantitative methodologies, like colorimetric and fluorometric assays, offer objectivity and high-throughput analysis. However, they require lengthy incubation times and only provide a single metric. Microscopy-based methods provide more information in terms of …

Identifying The Effects Of Environmental Conditions On Listeria Monocytogenes Fitness And Pathogenesis Modified By Transcription Factor Cody, Elizabeth K. Herr

Honors Theses

Listeria monocytogenes is a pathogen with the capability of causing severe illness in individuals who consume contaminated foods. Many foods have been found to harbor the bacterium, but dairy products, produce, and other prepackaged foods are particularly susceptible to contamination. Contaminated foods are exposed to a variety of environmental conditions during packaging, processing, consumption, and digestion, all of which play an essential role in modulating the survival and pathogenesis of L. monocytogenes. Conditions of particular interest include cold storage, presence of food additives, and activity of antimicrobial enzymes such as lysozyme. My honors thesis research has focused on elucidating how …

Unhappy Endings: Queer Time In Evelyn Waugh’S Brideshead Revisited, Caitlin G. Spicer

Honors Theses

This thesis examines Evelyn Waugh’s 1945 Catholic novel, Brideshead Revisited, through the lens of queer theory. My work focuses on reproductive heteronormativity and queer time and how these concepts can be used to analyze Waugh’s text. I argue that Charles and Sebastian, among other characters, step out of the traditional—or heterosexual—timeline in a way that queers temporality. I examine Sebastian, Charles, and Julia to understand how their lonely yet holy lives contribute to a larger tradition of unhappy endings in queer and Catholic fiction. In this thesis, I define reproductive heteronormativity as the assumption that people will follow a heterosexual …

Dispelling Delusion And Seeing Nature: A Comparative Analysis Of Lucretius’ _De Rerum Natura_ And Hui-Neng’S _Platform Sutra_, Isaac Raymond

Honors Theses

Lucretius’ De Rerum Natura and Hui-neng’s Platform Sutra have never been compared in a scholarly context; as such, this paper builds a new bridge between Western and Eastern philosophical literature, examining language, narrative, ethics, teleology, theology, and departures from orthodox philosophies in order to synthesize a clear and complete view of the two works in dialogue. De Rerum Natura, or On the Nature of Things, is a first-century BC epic poem composed in Latin by Titus Lucretius Carus which explains Epicurean philosophy in great detail through verse. The Platform Sutra is an eighth-century AD Chinese Zen (Ch’an) Buddhist sermon, …

Influences Of Sex, Morph, And Weather On Roosting Distributions In Overwintering White-Throated Sparrows (_Zonotrichia Albicollis_), Rebecca Stephens

Honors Theses

Habitat choice influences survival by affecting access to resources, shelter from predators, mating opportunities, and numerous other costs and benefits. As such, habitat conservation is crucial, especially for migratory songbirds which are declining primarily due to habitat destruction. White-throated Sparrows (Zonotrichia albicollis) are a well-studied migratory songbird, but little is known about their roosting behaviors or how those behaviors are affected by sex, color morph, or weather. To determine this, we tracked White-throated Sparrows to their roosts, determined core home ranges, and analyzed the average distances of roost sites to the home range centroids according to these factors. …

Policy Brief: Decreasing Unintended Pregnancy Rates In Mississippi, Jaycee S. Pilcher

Honors Theses

On June 24th, 2022, the U.S. Supreme Court’s decision to reverse Roe v. Wade marked a pivotal moment, eliminating the federal right to pregnancy termination. This thesis examines the challenges of restricted abortion access and emphasizes preventative strategies for unintended pregnancies. Analyzing both pre- and post-pregnancy interventions, such as enhanced sex education, hormonal contraceptives, insurance coverage, prescribers, and post-pregnancy policies, this thesis urges Mississippi residents and legislators to consider policy adjustments for reducing the occurrence of unintended pregnancies.

This research includes an analysis of literature, legislative records, and statistical data. It takes a comparative approach to evaluate the effectiveness of …

The Power Of Polish: Exploring The Impact Of Nail Adornments On Perceptions Of Attraction, Sara Demichele

Honors Theses

Understanding the significance of nail adornments in shaping perceptions of attractiveness and mate value provides insights into human behavior and preferences. In the current investigation, participants rated human nail length and color on physical attractiveness and partner desirability measures. Results revealed significant effects of nail length and color across different demographic groups. Medium-length nails consistently received higher ratings for physical attractiveness, cuteness, and partner desirability compared to short and long nails. White-colored nails were generally rated most attractive, while blue and black nails received the lowest ratings. Additionally, participants reported a moderate association between having manicured nails and feelings of …

Modeling The Opioid Crisis In Virginia: A Differential Equations Model Assessing The Impact Of Medication-Assisted Treatment On The Addicted Population, Maniha Zehra Akram

Honors Theses

The opioid epidemic is prevalent in countless communities throughout the United States and has yet to be mitigated. Treatments for OUD (opioid use disorder) include Medication-Assisted Treatment (MAT) and treatment without medication (non-MAT), with the former being judged as more effective in terms of lower relapse rates, death rates, and criminal activity (U.S. Food & Drug Administration, 2023; SAMHSA, 2024). Motivated by the promising research on MAT, this paper models the relationship

between the treatment and addicted populations using a system of ordinary differential equations. In addition to producing closed-form equilibrium solutions, the model leads to the conclusion that expanding …

Music And Healing In Aotearoa New Zealand: The Harmony Of The Land, Placehood, And Community In Māori And Pākehā Experiences Of Healing, Katherine Elise Callahan

Honors Theses

I explore the relationship between music and healing in Aotearoa New Zealand, and how healing is administered through the triadic relationship of the land, placehood, and community, using music as a vehicle for the carriage of this healing. In January of 2024, I traveled to Aotearoa New Zealand to gain a first-hand experience and account of this relationship through my own observations, and conducting interviews with Māori (the Indigenous people of Aotearoa New Zealand) individuals, and Pākehā (non-Māori) music therapists. Within this paper, I begin by providing context for this research within the fields of medical ethnomusicology, Indigenous studies, Māori …

Characterization Of Serx: A Putative Periplasmic Binding Protein In A Selenate Respiring Bacteria, Henry Jacques, Susan E. Childers

Honors Theses

A selenate respiring bacterium, Dechloromonas sp. A34, was isolated from a seleniferous mining site in southeastern Idaho. A34 was of interest due to its ability to respire up to 20 mM selenate, the highest concentration tested. The strain has been proposed to represent a new species of bacteria within the Dechloromonas genera, with the prospective name Dechloromonas selenatirespirans (manuscript in preparation). Our research presents characterization of a putative periplasmic binding protein found within an operon that contains genes encoding a putative selenate reductase. The gene, named serX (selenate reductase gene X), is 855 base pairs and encodes a putative …

The Social Implications Of Assisted Reproductive Technologies: An Analysis Of Feminist Discourse And Popular Media, Charlotte S. Buswick

Honors Theses

Assisted reproductive technologies (ARTs) have been a valuable tool in allowing many people to have children who previously struggled with infertility. However, feminists have raised the question: what impact do these new reproductive technologies have on women? This thesis investigates the discourse around the social implications of ARTs from the seventies to the present day. Looking at both feminist literature and portrayals of ARTs in women’s magazines, I performed a discourse analysis to track how the perception of the social implications of ARTs has changed over time. I also use a science, technology, and society (STS) studies lens to look …

Northern Shrimp In The Gulf Of Maine And The Impacts Of Climate Change, Alicia Hober

Honors Theses

Northern Shrimp (Pandalus borealis) populations within the Gulf of Maine collapsed in 2011 following the first year that sea surface temperature surpassed 10ºC. The population collapse resulting in a moratorium in 2014. The waters of the Gulf of Maine have been rising at a rate of 0.045ºC per year, changing predator distribution, prey distribution, as well as Northern Shrimp biological variables. There has been very little recovery to the Northern Shrimp stock despite the fishing moratorium and the answers behind the collapse and lack of recovery remains enigmatic. Therefore, this two-chapter study includes a literature review and a …

Black Rhino Conservation And Ranger Wellness In Namibia, Terra Gallo

Honors Theses

Wildlife rangers play an essential role in conserving biodiversity worldwide. Until recently, little was known about ranger working conditions and welfare. In 2019 the World Wildlife Fund (WWF) released a report that summarized survey results about ranger wellness from 7,110 rangers across multiple continents. However, the WWF study had geographic gaps and did not survey rangers from southern Africa, including the Republic of Namibia. In Namibia, rangers in the Kunene region are central to the conservation of the desert-adapted black rhino. Save the Rhino Trust (SRT) is a Namibian organization that supports rhino rangers and black rhino conservation. The aim …

Reviving Caribbean Scleractinian Corals: Medication In Ex-Situ Care, Christopher E. Cho

Honors Theses

The Caribbean basin is facing an unprecedented decline in coral reef health, with factors such as coral disease, climate change, and algal overgrowth contributing to the deterioration of these vital ecosystems. In response, land-based facilities have emerged to aid in coral conservation and restoration efforts. One aspect of these conservation efforts involves the treatment of coral ailments, which is still an emerging field within coral conservation. By medicating corals, researchers aim to combat diseases and alleviate stressors that threaten coral health. This practice holds promise for preserving genetic diversity and supporting future repopulation initiatives. This study evaluates the effectiveness of …

Interactional Queerscapes: Representations Of Men Attracted To Men In South Korea, Tegh Khosla

Honors Theses

This thesis explores the representations of men attracted to men (MAM) in South Korean media through the theoretical lens of queerscapes. Queerscapes refer to the physical and metaphorical spaces alternative queer existences occupy amidst dominant heteronormative environments. By analyzing a queer independent film, a bestselling novel, and a subversive boys’ love (BL) drama, this study examines how characters in these media actively carve out alternative spaces of existence. The first chapter delves into the concept of queerscaping as a verb to articulate direct conflict with intolerant institutions and dominant ideologies that seek to suppress non-normative sexualities. This precarious balancing act …

Sprtn Metalloprotease As A Target To Sensitize Cancer Cells To Crosslinking Chemotherapy, Cole J. Turner

Honors Theses

Bifunctional alkylating agents have demonstrated high clinical utility as a chemotherapeutic strategy against cancer. These compounds have been well-characterized for their capacity to exert cytotoxicity via interstrand DNA crosslinking. However, the same electrophilic chemistry can also form DNA-protein crosslinks (DPCs) whose contributions to these drugs’ antitumor effects have been less well-defined. Recently, the metalloprotease SPRTN has been implicated as a predominant mediator of DPC repair in mammalian cells. Previous work has demonstrated that SPRTN deficiency increases the sensitivity of cancer cells to DPC-inducing agents such as formaldehyde and cisplatin, but these findings have yet to be translated more broadly across …

Modification Of Marine Snail Microhabitats By Canopy-Forming Algae, Eleanor Mcgrath

Honors Theses

Brown algae, including the canopy-forming macroalgae Fucus distichus, are declining in abundance around the world due to stressors associated with climate change. Local extinction of Fucus impacts the intertidal community through cascading effects as the ecosystem loses a dominant primary producer at the base of the food web. However, Fucus is not only a resource species; it is also an ecosystem engineer. This thesis investigates the effect of Fucus extinction on the abundance of two herbivorous marine snails, L. saxatilis and L. obtusata, with a focus on the role of Fucus as a habitat- modifier. Specifically, I explored: …

The Physicians' Crusade: A Forgotten War On Abortion, Feminism, And The Diversification Of The United States, Lucinda B. Harden

Honors Theses

Abortion in the United States was accessible and widely practiced until the mid- nineteenth century. In 1857 the physicians’ crusade, an anti-abortion political movement led by prominent medical doctors around the country, instigated the widespread criminalization of abortion by the end of the century. I argue that physicians wielded their scientific authority to validate increasingly conservative attitudes about race and gender. They appealed to national xenophobic and sexist backlash that accompanied progressive changes like industrialization and the abolition of slavery, amplifying those fears and offering politicians a source of control over female sexuality and a growing immigrant population: the criminalization …

Measuring Nature’S Contributions To People Provided By Species In The Gulf Of Maine Rocky Intertidal Ecosystem, Madelyn L. Eippert

Honors Theses

Ecosystem services aim to quantify the value of nature provided to humans. However, Ecosystem services are typically measured at the level of the ecosystem as a whole and do not consider interactions between species in an ecosystem. Ultimately, the species in an ecosystem determine the services that are provided. Measuring ecosystem services at the landscape level misses the complex interactions and changing biodiversity of ecosystems. Currently, there is no accepted framework to link ecosystem services to species. In this thesis, I developed a framework to link Nature’s Contributions to People (NCP) to species. NCP includes 18 specific contributions (i.e. 18 …

Computational Study Of Proton Transfer At Transition Metal Hydrides, Megan Ford

Honors Theses

Energy storage in the bonds of common chemical feedstocks is an attractive solution to the unreliability of wind and solar power due to its long term efficiency and easy recoverability. Energy is stored by reducing chemicals like ammonia, formic acid, and hydrogen, the reaction of which is dependent on a catalyst. To catalyze the reaction, the catalyst undergoes a slow proton transfer (PT) step to form what is known as a metal hydride. The sluggish kinetics of this step lower the effectiveness of the catalyst, and therefore must be better understood in order to improve the efficiency of energy storage …

Development Of A Diaryl Oxazole-Based Cleavable Linker For Peptides, Evan Wolff

Honors Theses

The development of new cleavable linkers increases the diversity of compatible conditions for peptide discovery platforms. Potential applications for these linkers include high-throughput pharmaceutical candidate screening when utilized in Peptide Encoded Libraries (PELs). This thesis describes the development of a bifunctional diaryl oxazole-based cleavable linker that may be incorporated into compounds through Solid-Phase Peptide Synthesis (SPPS). This oxazole-based linker may be rapidly cleaved by cerium ammonium nitrate in aqueous conditions and is compatible with most natural amino acids and a variety of unnatural amino acids. This linker represents the first single-electron oxidant labile linker described to our knowledge and it …

Opioid Policy Solutions: Administrative Law, Legislation, And Constitutional Reform, Trevin Stevens

Honors Theses

I have written three separate policy briefs addressing issues in the pharmaceutical industry that allowed for the opioid epidemic to reach the magnitude that it has in the last three decades. I examined public policy regarding labeling, drug diversion, and misuse, as well as marketing. By studying existing policies, I was able to provide insight into possible reforms, while accounting for potential obstacles to systematic reform, such as constitutional concerns regarding free speech.