Digital Commons Network^™

Game Night! Assessment Of Playability And Learning Effectiveness Of Active Learning Games In Human Anatomy And Physiology Students, Hannah Brady

Honors Theses

Human Anatomy and Physiology (HAP) courses are a requirement for many students pursuing an education in healthcare. Students tend to dread these courses for their abundance of information in such a short amount of time. These courses tend to have a low success rate because students are not adequately prepared for this upper-level class that requires intense dedication and studying. This problem for students is extreme as these courses are required for most pre-health undergraduate students, and these courses may predict their success in their future education. HAP professors are constantly trying to figure out better ways to get students …

Reproductive Justice In Mississippi: A Call For Reform And Acknowledgement, Andie Udziela

Honors Theses

In this thesis, I apply the values of the Reproductive Justice Movement to reproductive healthcare resources in Mississippi to advocate for reproductive policy reform. I begin by navigating the historic racial discrimination in gynecology and how it manifested in Mississippi. Dr Sim’s abusive experimentation on Anarcha, Betsy, and Lucy depict how Anti-Black racism took root in gynecology and obstetrics and was later expanded on by the eugenic goals of white supremacy and the feminist movement through Margaret Sanger and the Mississippi Appendectomy. Then I discuss the current availability of reproductive care in Mississippi to low-income individuals to emphasize socioeconomic and …

An Investigation Of Bone Preservation As A Result Of Environmental And Cultural Variables In Mortuary Contexts, Adyn Hallahan

Honors Theses

Stable isotope analysis in bioarchaeology of human bone is generally used to reconstruct diet or migratory patterns of certain populations. Although this type of analysis is now standard practice, little research has been done regarding how cultural and mortuary practices may affect chemical composition of bone. This study aims to determine whether different simulated mortuary contexts have an effect on stable isotope levels in bone, using seven pig rib bone samples as proxy for human bone. In addition, macroscopic and microscopic observations are used to assess preservation and taphonomic processes. One of the samples served as a control, not being …

Perseverative Thinking And Thought Suppression: Links To Medication Non-Adherence Among Adults With Type 2 Diabetes, Aswin Arunachalam, Aaron Lee

Honors Theses

Medication nonadherence in patients with type 2 diabetes contributes to poor glycemic control which often results in the development of serious and irreversible diabetes-related complications. This study examines the role of the maladaptive cognitive processes of rumination and thought suppression on medication nonadherence in patients with type 2 diabetes. The sample for this study (N = 343) consisted of adults (mean: 55, range: 19 – 85) with type 2 diabetes enlisted through a web-based platform. Participants completed a series of validated questionnaires including the Perseverative Thinking Questionnaire, White Bear Suppression Inventory, and Difficulties in Emotion Regulation Scale. Binary logistic regression …

Andrews University Pre-Professional Students Preparedness For A Future With Artificial Intelligence, Zachary Alignay

Honors Theses

Artificial Intelligence technology has advanced considerably over the past four years. With such rapid technological development, the question has to be asked if students are adequately educated on the implications and abilities of artificial intelligence. Are Andrews University pre-professional students prepared for future careers with artificial intelligence? To approach this question, a survey of students across multiple perspectives was conducted to sample if there was a consensus, or lack thereof, on the perception of ethics regarding artificial intelligence, to ask students how using artificial intelligence has changed their education, what purposes it can be used or cannot be used, personal …

Investigating A Family Of Fungal Pseudopeptidases With Bioinformatics Tools, Andy Zhao

Honors Theses

Enzymes catalyze chemical reactions; however, some proteins related to enzymes lack enzyme activity. To investigate changes that occur as enzymes becomes pseudoenzymes, I studied a unique family of fungal carboxypeptidases. I identified all fungal carboxypeptidase protein sequences in the NCBI database, constructed an alignment and phylogenetic tree for sequence comparison, and used Alphafold2 for 3D modeling of representative proteins. Fourteen unique groups were identified. All fungal proteins selected are separated into 3 categories, predicted to be active, intermediate, and inactive, respectively. Proteins predicted to be pseudoenzymes contained additional loops in mutation hotspots not found in predicted active enzymes. This research …

Induction And Modulation Of Apoptosis In Breast Cancer Cells Mda-Mb-157 And 93b By Chinese Medicinal Herbs Oldenlandia Diffusa And Bryophyllum Pinnatum, Sarah Wolf

Honors Theses

Chinese medicinal herbs have been found to contain bioactive phytochemicals with anti-cancer properties. Herbal extracts induce apoptosis in cancer cells by modulating levels of pro- and anti-apoptotic proteins. A previous study showed that a commonly used herb, Scutellaria barbata, significantly induced apoptosis in the breast cancer cell line MDA-MB-157 and the therapy-resistant breast cancer cell line 93B. However, the effects of two different Chinese herbs, Oldenlandia diffusa (OD) and Bryophyllum pinnatum (BP) on these breast cancer cells are not known. This project indicates the influence of the herbs OD and BP on apoptosis of breast cancer cell line MDA-MB-157 in …

Bone Marrow Donor Recruitment Drive And Registry, Elizabeth R. Dovich

Honors Theses

Bone marrow transplants are vital for those with blood cancers and disorders, but not every ethnic group has an equal chance of finding a match. Some of the human leukocyte antigen (HLA) cell markers used to match donors and recipients are unique to certain ethnic groups, making it harder for members of those groups to find a match. This project worked to address this inequality by organizing a bone marrow registry recruitment drive on the campus of Andrews University in partnership with the NMDP registry. It encompassed the planning, promotion, and execution of the drive which took place March 5-7, …

Induction And Modulation Of Apoptosis In Breast Cancer Cells 93a And Mda-Mb-157 By Chinese Medicinal Herbs Oldenlandia Diffusa And Bryophyllum Pinnatum, Rekha Isaac

Honors Theses

Chinese medicinal herbs, such as Oldenlandia diffusa, contain phytochemicals that exhibit antitumor, chemopreventive, and antiangiogenic effects in cancer cells. In this study, both Oldenlandia diffusa and Bryophyllum pinnatum (a lesser-studied herb) were tested on breast cancer cell lines MDA-MB-157 and 93A by administering an aqueous extract. The effectiveness between cell lines was also compared. The apoptotic effect both herbs showed was quantified by the levels of pro and anti-apoptotic proteins expressed in each cell line. Both cell lines treated with Oldenlandia diffusa and Bryophyllum pinnatum showed significant differences in their levels of both pro and anti-apoptotic proteins when compared to …

Synthesis Of Novel Temozolomide Amides As Potential Anti-Glioblastoma Agents, Sion Kim

Honors Theses

Glioblastoma is treated with Temozolomide (TMZ), a lipophilic alkylating drug that can cross the brain-blood barrier. To confront drug resistance, this research aimed to synthesize novel TMZ amide hybrids by using the acid chloride method, replacing an amino group with a primary amine. These novel hybrids were tested on U87-MG cells to determine if the primary amines with greater anticancer properties and lipophilicity have enhanced the drug's anticancer activity and bioavailability. The calculated lethal concentration 50 (LC50) of the hybrids ranged from 0.005 mg/mL to 0.2258 mg/mL, with some demonstrating greater anticancer effects than TMZ itself.

Migratory And Non-Migratory Yellow Perch Differ In Locomotor Traits, Wade Poling

Honors Theses

Yellow Perch (Perca flavescens) are widely distributed throughout the Midwest and are popular game fish and table fare. Seasonally, some eastern Lake Michigan Yellow Perch migrate into drowned river mouth lakes. Drowned river mouths are highly productive environments that also hold non-migratory resident Yellow Perch. Migration requires substantial energy expenditure; therefore, we expected migratory Yellow Perch to evolve locomotory traits that optimize energy efficiency for swimming long distances. We expected drowned river mouth lake resident Yellow Perch to evolve locomotory traits that enhance maneuverability, which are beneficial in avoiding predators, capturing prey, and moving through the structurally complex littoral …

The French Divorcee And Her Evolution, Mackenzie Bialzik

Honors Theses

This thesis serves to explore the greater questions concerning patterns of divorce in France and how women, through divorce, experienced greater liberties within the law. The evidence used in this paper stems mainly from demographic data, opinion pieces on divorce, and legal journals. While I had hoped to access specific divorce hearings, privacy laws in France and the language barrier prevented me from this type of research. Through my research I have found that divorce did not follow typical trends in feminist movements as expected in France. Instead, divorce was reactionary of the social perceptions of marriage and gender. Additionally, …

How Social Movements Have Influenced Child Custody Standards Over Time, Victoria Miller

Honors Theses

Child custody standards have evolved over time due to societal attitude shifts regarding gender roles. The stereotypes present within the decision-making process of child custody laws have been challenged repeatedly in order to attack sexism within the laws. Child custody decisions are important for the child and family in question, because whichever parental guardian has custody over the child has the legal authority to make life changing choices for the child. These choices can include education, religion, and the environment the child grows and develops in. Parental choices can affect a child's mental and physical well-being, which makes it crucial …

Production Of Mrna Vaccine For Influenza, Christina Miller

Honors Theses

The objective of this project is to design a process to produce an mRNA influenza vaccine that serves as an alternative to conventional influenza vaccines, replacing current options with innovative mRNA technologies. Given that older populations are most likely to follow up on immunizations consistently, and the increasing average age worldwide, the market for this project appears to be expanding in the next 80 years. Additionally, experts predict more frequent mutations and outbreaks of viral disease from a variety of factors including globalization and global temperature trends. Rapid response to these viral outbreaks will continue to be as, or even …

How Does Childhood Exposure To Toys And Video Games Relate To Young Adult’S View On Gun Control?, Shelby Wilmot

Honors Theses

The present study investigated the factors influencing support for gun control and attitudes toward gun control restrictions on individuals, specifically violent video games and toys. From the 119 total responses collected, 78 (65.5%) of the participants identified as female, 34 (28.6%) of the participants identified as male, and 7 (5.9%) of the participants identified as nonbinary. Regression analyses were conducted to examine the relationships between various independent variables and the dependent variables representing these attitudes. For the dependent variable measuring support for gun control, the model summary revealed a moderate correlation

(r = .610), with approximately 37.2% of the variability …

Veterinarian Perception Of The Impact Of Covid-19 On The Mortality Of Pets, Jason Bainbridge

Honors Theses

The pandemic led to many changes in society, changes that may have affected pets either directly or indirectly from the new way people had to live life. The primary variable of investigation is if the changes were significant enough to affect pets enough to see a trend in mortality. This thesis used a survey, sent out to veterinarians for their perspective, to see the effects the pandemic had on the mortality of pets, as well as any secondary variables. This survey had 38 responses, with 34 being eligible to complete the survey. The survey did not obtain the information of …

Evaluation Of Seizure Recognition And First Aid Training Course And Improving Self-Efficacy Related To Medical Emergencies In Mississippi, Anna Katherine Herrington, Collin Earl Wayne Crawson, Daniel Robert Zuckerman

Honors Theses

Within recent years, there has been increased attention to the growing physician shortage across the United States. This shortage has placed substantial strain upon regions of lower healthcare access, particularly those of rural regions such as much of the state of Mississippi. As rural healthcare providers are placed under more strenuous conditions, they encounter issues of increased patient volume, lack of a trauma team, or adequate transportation to higher-level care facilities. These issues may exacerbate the present inequities in cost of living, access to adequate healthcare, and the distress caused by these concerns. Individuals with epilepsy are one cohort with …

Understanding The Mechanism Behind Hfip's Effect On Diastereomeric Separation Of Oligonucleotides, Ian Neidigh

Honors Theses

The goal of this research was to determine the mechanism behind 1,1,1,3,3,3-hexafluoroisopropanol's (HFIP0 ability to suppress the separation of oligonucleotide diastereomers. This was accomplished by selecting different molecules that were like HFIP but differed in specific ways such as polarity, number and type of halogen(s), alcohol group location, carbon chain length, hydrophobicity, and chao/kosmotropicity. These molecules replaced HFIP in an IPRP chromatography method to determine if splitting of the diastereomers was observed and then they would becompared to HFIP's effect. Viscosity tests were to run to acquire quantitative data to determine chao/kosmotropicity. No decisive trend among a single factor was …

Examining Confidence In Scientific Literacy Amongst General Biology And General Chemistry Students, Amy Sullivan

Honors Theses

Scientific literacy is a term used to describe a person’s ability to understand scientific concepts, read and write those concepts, and link those concepts to situations outside of the classroom in order to make informed decisions in their daily lives. This research paper details a study observing how scientific literacy confidence varies among general biology and chemistry students at the University of Mississippi. The goal of this research is to determine if students in general biology and chemistry classes will have similar self-reported confidence in their science literacy. This research took place at the University of Mississippi amongst Biology 160/161 …

Princess Proportions & Perceptions: Disney’S Deterioration Of Young Girls’ Self-Esteem, Marah Krick

Honors Theses

Animated children’s media is becoming increasingly thinner, particularly as society demands continually smaller waists in the ideal female body size. The present study is focused on analyzing the origin and effects of abnormally small waist-to-hip ratios in animated Disney Princesses on a younger, primarily female audience. Exposure to these unrealistic body standards may result in internalization that leads to body dissatisfaction, as well as a drive for impossible thinness that results in disordered eating, mental health concerns, and suicide ideation. Adolescents and preadolescents are particularly at risk, due to daily entertainment screen time nearly tripling since 1999. While the risks …

In The Garden Of Skincare: Exploring The Benefits And Regulations Of Botanical Ingredients, Sara L. Cook

Honors Theses

With the rising consumer demand for more natural skincare products, botanical ingredients have become more prevalent in skincare products. Skincare products with botanical properties are being preferred over those with chemical properties due to their biological origins. However, there are debates as to why botanical products are being used widespread and if they are safe to use. The safety of ingredients within cosmetics is observed by multiple regulatory systems throughout the world. These regulatory systems oversee making sure that each ingredient is extracted and purified before being incorporated into a cosmetic or skincare product. One goal of this project was …

The Effects Of A Mindfulness Intervention On Ameliorating Premenstrual Hedonic Eating Patterns In College-Aged Females, Nicole R. Palmieri

Honors Theses

Background: Young women in college are susceptible to weight gain from a myriad of factors to include environmental and hormonal influences.

Objective: The aim of this study was to determine the impact of a mindfulness intervention on food craving behaviors in women in the luteal and follicular phases of the menstrual cycle.

Methods: This was a quasi-experimental study using repeated samples one-way ANOVA and qualitative data to examine pre-intervention and post-intervention changes in cravings and mindfulness.

Results: 23 participants completed the intervention and study-related requirements pre-intervention and post-intervention. There was a trend of mean decrease in FCQ-T scores (124.83 ± …

Exploration Of Cytotoxicity Of _Rabidosa Rabida_ Venom On Invertebrate And Vertebrate Cell Cultures, Martina Gooden

Honors Theses

Venom has been observed in thousands of species across different taxa. It can be adapted for different purposes, including prey capture or predator defense. Venom is found almost universally in spiders, but there has been little exploration of spiders that are not medically significant. Rabidosa rabida, the rabid wolf spider, is a common species whose venom has not been adequately investigated. Previous studies indicate that they do not require venom to apprehend easy prey in a laboratory setting, raising a question as to what their venom is adapted to do. To evaluate its effect on mammalian cells, L929 murine fibroblasts …

“You Just Haven’T Found The Right Person Yet.”: A Study Of The Relationship Differences Between Asexual And Allosexual Individuals, Faith M. Conway

Honors Theses

Asexuality is an underreported and scarcely researched group. This study aimed to determine relationship and relationship goal differences between asexual and allosexual individuals. Using 134 responses to a Qualtrics survey, the current research found only one self-identified asexual individual and five total Asexuality Identification Scale identified individuals. Results showed little difference between Allosexual and Asexual relationships and relationship goals. There was a significant difference between the realization of an identity different from heterosexual and the self-claiming of an identity name.

Hab Cyanobacteria In Northeastern Sc Retention Ponds: Time Trends In Abundance And Relationship To Water Quality, Kathryn I. Hanson

Honors Theses

The accumulation of polluted runoff in retention ponds can create water quality conditions that favor development of harmful algal blooms, including toxin-producing cyanobacteria. This can present a health risk to pedestrians and nearby residents, as many such ponds are surrounded by walkways or housing complexes. Blooms can also cause harm to natural ecosystems, periodically causing hypoxic conditions and toxin buildups. This study aims to form a more complete understanding of the population dynamics of certain potentially harmful phytoplankton genera, in relation to water quality parameters in retention ponds. Sampling was performed in five ponds chosen to reflect a variety of …

Validation Of A Passive Sampler For Tracking Harmful Algal Toxins In Natural Waters, Hailee Eiker

Honors Theses

Algal blooms that produce toxins that are harmful to the health of people, animals, and the environment are known as harmful algal blooms (HABs). Recently, rising global temperatures, nutrient pollution, and an increase in the frequency of extreme hydrologic events have made HABs a bigger problem. This has all led to greater cultural eutrophication which is a major contributor to the spread of HABs. Cyanobacteria make up the bulk of HABs in freshwater systems, microcystins being among the cyanotoxins that are most frequently reported and studied. Taking grab samples of water is the current standard procedure for sampling cyanotoxins, however, …

Effect Of Downregulating Lactate Dehydrogenase In Alzheimer’S Disease Using A Drosophila Model, Hannah Higgins

Honors Theses

According to the CDC, approximately 5.8 million Americans suffered from Alzheimer’s disease (AD) in 2020. AD is characterized by progressive memory loss and typically develops after the age of 60. There are many studies that suggest different causes of Alzheimer’s such as oxidative damage, amyloid plaque buildup, and metabolic dysfunction. Lactate Dehydrogenase (LDH) is an enzyme that is found in many tissues within the body and functions within cellular metabolism. The enzyme catalyzes the reversible reaction that converts lactate to pyruvate coupled with the reduction of NAD+ to NADH. Pyruvate is then used in the Krebs cycle to create ATP. …

Computational Study Of Substituent Effects On The Diels-Alder Reaction Involving Furan And Maleimide For Hydrogel Synthesis, Matthew Phillips

Honors Theses

This research utilized a computational study with SPARTAN’20 software to analyze the energetics of the Diels-Alder (DA) reaction between substituted furan and maleimide. The products of this type of reaction can lead to the production of hydrogels. Hydrogels are used in multiple biomedical applications, such as controlled drug delivery systems, wound dressings (liquid bandages), contact lenses, and more. The DA reaction involves a diene (a hydrocarbon with two conjugated π bonds) and a dienophile (a hydrocarbon with one π bond). Research on the placement of electron withdrawing and electron donating groups onto the dienophile and diene has been completed in …

Effects Of Paternal Heat Exposure And Parental Care On Development Of Offsring In Gasterosteus Aculeatus, Emma R. Borgert

Honors Theses

Humans are profoundly altering the abundance and distribution of organisms via climate change. Warming temperatures are affecting marine and freshwater ecosystems by increasing physiological stress, limiting growth, and decreasing dissolved oxygen. With all this change occurring, an understanding of how organisms are going to cope is crucial. Transgenerational plasticity – when parental experiences alter offspring traits - can allow organisms to rapidly adapt to environmental change. Previous literature has focused on the role of maternal experiences on offspring traits, but paternal experiences are just as important. Fathers can influence their offspring in multiple ways, including changes via both sperm and …

Improving Methods For Enantioselective Organophosphorus Synthesis By A Chiral Nucleophile-Metal Bifunctional Catalytic System, Jackson T. Shuman

Honors Theses

The use of benzotetramisole (BTM) as a catalyst is a promising strategy for enantioselective organophosphorus synthesis since the reaction has been previously reported by Numan and Brichacek and has been tested in Dr. Erb’s research laboratory. However, the yields are only moderate (46-58%) and the enantiomeric excess (ee) of the purified product are poor, with 62% being the highest reported ee. Preliminary computational data performed in the Erb lab has revealed that the cause of the lower ee (and possibly yield) could be the ability of the intermediate to adopt different conformations that are similar in energy and would therefore …