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Monitoring Aerosols With Time Resolution With A Rotating Drum Sampler Using La-Icpms For Elemental Analysis, John V. Piorkowski

Honors Theses

This thesis presents a comprehensive study on the characterization and application of a rotating drum sampler for air quality monitoring, with a focus on aerosol composition analysis using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICPMS). The study aimed to determine (1) the cut-off points of the drum sampler to better understand its performance characteristics and (2) to investigate indoor air quality, specifically within makerspaces on Bucknell University’s campus. The research highlighted the novelty of applying LA-ICPMS for time-resolved aerosol composition analysis, demonstrating the potential for low-cost pollution concentration studies. The characterization experiments did not yield expected results, but the …

Experimental Evaluation Of Mesh Size In Physically Crosslinked Polymer Gels Using Dynamic Light Scattering, Duncan M. Hill

Honors Theses

Block copolymer gels are under consideration as drug delivery patches. Controlling and modeling the transport inside the gel is an important contribution to the successful delivery of pharmaceuticals. The diffusive transport of a solute – such as a therapeutic compound – within the gel can be described by the mesh size of the gel, which is defined as the distance between polymer chains. Existing experimental evaluations of mesh size do not work for block copolymer gels due to differences in the fundamental gel structure. As such, an experimental method of measuring mesh size of block copolymer gels using dynamic light …

Associations Between Loneliness And Social Anxiety: Predictors Of Life-Satisfaction In Young Adults, Desiree Groce

Honors Theses

This research builds upon current findings pertaining to life-satisfaction. Loneliness, related to inadequate well-being, has been shown to negatively affect various domains of one's life. Moreover, Social Anxiety Disorder (SAD) has negative consequences that have been shown to affect the quality of one's well-being. The present research conducted two studies to elucidate the connection between loneliness and SAD as potential predictors of life-satisfaction. The first study sought to clarify the relationship between social and emotional loneliness and life-satisfaction. It was predicted that lower social loneliness scores will predict higher life-satisfaction scores, and lower emotional loneliness scores will predict higher life-satisfaction …

A Comparison Of Symptom Profiles In Probands With 16p11.2 Deletion And Duplication Syndromes: Repetitive Behavior And Psychosis Proneness, Adrianna Rakauskas

Honors Theses

The present study examines two classes of behavior in probands with the 16p11.2 duplication and deletion: repetitive behavior and psychosis spectrum behavior. It was hypothesized that 1.) deletion and duplication cases will differ significantly in the means and profiles of repetitive behaviors across five subscales and 2.)16p11.2 duplication cases will exhibit more schizotypal traits than the deletion cases. Data on 94 total participants was obtained from the Simmons Variation Individuals Project. Three scales were used to measure behavior: the Childhood Routines Inventory-Revised, the Childhood Oxford-Liverpool Inventory of Feelings and Experiences, and the Child Behavior Checklist. Data analysis was conducted using …

Curriculum, Knowledge, And Power: A Critical Race Approach To Content Analysis Of Social Studies Textbooks, Eliza G. Ray

Honors Theses

This study uses Critical Race Theory (CRT) as a theoretical framework to examine the portrayal of the U.S. Revolutionary War in three 5th grade social studies textbooks approved by the state of Florida’s curriculum standards. Textbooks have been a focal point for political debate, most recently influenced more by politicians than by educators. A qualitative rubric was developed to evaluate the textbooks, examining the extent to which they include a CRT telling of the Revolutionary War. This rubric was informed by the tenets of CRT in educational research as described by Solorzano and Yosso (2002). Consistent themes arose from the …

Examining The Relationship Between Subclinical Borderline Personality Disorder And Social Support Networks, Gabriella D'Alicandro

Honors Theses

The purpose of my study was to investigate the relationship between subclinical Borderline Personality Disorder and social support in situational measures such as social provisions, network size, and network satisfaction as well as dispositional measures such as support seeking and socially supportive behaviors. I hypothesized that BPD scores would be negatively correlated with all dispositional support measures. I also predicted that in situational support measures, BPD would have a negative correlation. I hypothesized when confronted with romantic stressors participants would receive more support when confounded with the workplace stressors. Participants (N= 178; 146 women 28 men, 3 nonbinary individuals, and …

An Investigation Of The Correlation Between Polymer Solution Entanglement And Electrospun Polycaprolactone Fiber Mechanics, Manasa Sujatha Rajeev

Honors Theses

The aim of this study was to determine the role of entanglement in the mechanical properties of electrospun polycaprolactone (PCL) fibers. PCL is a useful polyester due to its favorable properties such as its biocompatibility and biodegradability. Multiple concentrations of PCL were dissolved in a 3:1 acetic to formic acid solvent. Fibers were formed using an electrospinning technique. Entanglement is a required parameter to produce fibers, thus the number of entanglements per polymer (ne) was calculated, as well as the corresponding concentrations. Smooth continuous fibers were found to form between 13 w/v% and 17 w/v%. Mechanical analysis, such as three-point …

Trading Perspectives: The Impact Of Gender In Shaping National Trade Policies, Katherine Kwiatkowski

Honors Theses

Economic and political factors have been shown to influence the trade policy decisions of national leaders. The impact of a national leader’s gender on their trade policy preferences remains an underexplored area of research. The increasing share of female national leaders raises the question of whether their policy preferences vary from those of male leaders because of their gender. In this study, I utilize the gender of a nation’s leader to implement a two-way fixed effects regression that analyzes the impact of gender on a leader’s trade policy preferences. Controlling for factors that could also impact a leader’s trade policy …

Functionalized Gold Nanoparticles And Halogen Bond Interactions With Neonicotinoid Pesticides, Molly Mccuen “Mackey” Sherard

Honors Theses

Neonicotinoid (NN) pesticides have emerged globally as one of the most widely used agricultural tools for protecting crops from pest damage and boosting food production. Unfortunately, some NN compounds, such as extensively employed imidacloprid-based pesticides, have also been identified as likely endangering critical pollinating insects like honey bees. To this end, NN pesticides pose a potential threat to world food supplies. As more countries restrict or prohibit the use of NN pesticides, tools are needed to effectively and quickly identify the presence of NN compounds like imidacloprid on site (e.g., in storage areas on farms or pesticide distribution warehouses). This …

Black And Blue All Over: Whose Lives Matter?, Bella Purvis

Honors Theses

This study investigated the influence of beliefs about race on support for the Black Lives Matter (BLM) and Blue Lives Matter (BluLM) movements, mediated by attitudes towards police and beliefs about white privilege. Utilizing a sample of undergraduate university students, data were obtained through a survey measuring beliefs in the biological and social constructs of race, support for police, belief in white privilege, and attitudes toward BLM and BluLM. Results indicated that individuals who perceive race as a biological construct are less likely to support BLM and more likely to support BluLM, while beliefs in white privilege and attitudes towards …

The Effects Of Parasitoid Wasps On The Intra- And Interspecific Competition Of Zaprionus Indianus, Camille R. Walsh-Antzak

Honors Theses

Understanding the mechanisms underlying the success of biological invasions is essential to employ effective prediction and management strategies. The release of natural enemies in invaded regions (enemy release hypothesis) and increased competitive ability are major hallmarks of invasive species, however, these two processes are rarely studied within the same context. Here, we examined the role of ERH in influencing the competitive outcomes of an invasive insect pest, the African fig fly (Zaprionus indianus). In Virginia orchards, Z. indianus repeatedly outcompetes co-occurring drosophilid species. However, the mechanisms underlying the success of Z. indianus are poorly understood. Parasitoid wasps specializing in Camill …

Cd46 Interaction With Adenovirus Type 64, A Causative Agent For Viral Pink Eye, Hanglin (Henry) Zhu

Honors Theses

Human adenovirus type 64 (Ad64) is a causative agent of contagious viral pink eye. We do not understand why Ad64 causes eye infections. One likely reason is the presence of a receptor molecule on the exposed surface of eye cells, but not other cells. Ad64 binds to a protein called CD46 on the cell surface. We aim to visualize how CD46 binds to the surface of Ad64. I mixed the extracellular portion of CD46 with purified Ad64 virus, then visualized it using negative stain transmission electron microscopy. In order to gain insight into how the virus binds CD46, we used …

Cd46 Isoforms And Viral Receptor For Adenovirus Type 64d, Corina Stasiak

Honors Theses

Adenovirus Type 64 (Ad.64) belongs to the adenovirus subgroup D, which causes epidemic keratoconjunctivitis (EKC), otherwise known as viral pink eye. There is currently no known effective treatment for EKC. Membrane Cofactor Protein (CD46) is an integral membrane glycoprotein that, in previous studies, has been identified as a protein receptor for the closely related Ad.37. It has been determined that Ad.64 uses CD46 as a receptor on the cell surface in HeLa cells. CD46 is alternatively spliced when expressed to have different isoforms of interest, including the BC and C isoforms. Certain cell types, like A549 lung carcinoma cells, express …

Cd46 Is A Protein Receptor For Human Adenovirus Type 64, Alexander Michael Robertson

Honors Theses

Adenoviruses are important gene delivery vectors and causative agents for a variety of human diseases such as the common cold and gastrointestinal infections. Human adenovirus type 64 (Ad64; formerly 19c) and type 37 are associated with epidemic keratoconjunctivitis. Based upon its high homology and similar disease tropism to Ad37, we hypothesized that Ad64 would have the same protein receptor, CD46 (membrane cofactor protein), as Ad37. We show that a recombinant Ad64 containing an enhanced Green Fluorescent Protein transgene (Ad64.eGFP) enters Chinese hamster ovary cells expressing human CD46 (CHO-CD46) on the surface. Entry into human cervical carcinoma (HeLa) cells is increased …

Exploration Of Sulfonamides And Benzothiazoles As Peptide-Based Cleavable Linkers, Abigail Dalton

Honors Theses

Cleavable linkers have demonstrated great potential in various applications of medicinal organic chemistry, such as in modern therapeutic development. Linkers are stable compounds that cleave in specific conditions to release molecular cargo. We have developed cleavable linkers based on nucleophilic aromatic substitution reactions on sulfonamide and benzothiazole substrates in small molecule and in peptide studies. Sulfonamides, commonly with an electron-withdrawing group, reacted in high conversion of starting material to the sulfide product in small molecule studies, but was unable to successfully cleave the sulfonamide linker on peptide in mild conditions. Next, a benzothiazole sulfone substrate was analyzed and optimized in …

Unpredictable Positive Experience Response (Uper) Training In Male And Female Rats: Effects On Cognition, Emotional Resilience, And Neuroplasticity Markers, Eve M. Barringer

Honors Theses

This study investigated the effects of positive anticipation on depression-like symptoms in Long Evans male and female rats, using Unpredictable Positive Experience Response (UPER) training. Rats that received UPER training (UPER group) were exposed to cues followed by a positive reward at random times, fostering anticipation of three different positive experiences. Along with the UPER rats, there was a group of rats that received positive rewards without anticipation (ENR group) and a group that received no positive reward or anticipation (CTRL group). After 7 weeks of behavioral… training, we examined how training impacted the animal’s cognition, emotional resilience, and neurobiological …

(Re)Constructing Race: How Essentialist Beliefs Shape Social Justice Support, Abbey Alvarado

Honors Theses

The political climate and social discourse around social justice has grown increasingly tense and hostile in recent years. The current study investigated potential predictors of the opposition to support for racial equity and social justice reforms. Research illustrates that a biological conceptualization of race (“essentialism”) has powerful implications on information processing and social-psychological outcomes regarding issues of race and racism. In the current study, we conducted a survey of 164 University of Richmond undergraduate students. The survey examined the interplay of essentialism and beliefs about systemic racism and white privilege on social justice support. The results showed that essentialist beliefs …

Structural Phylogenetics Of A Family Dna Polymerases, Yagmur Bingul

Honors Theses

The transition from the RNA to the DNA world stands as an important event, demanding the emergence of enzymatic activities for DNA precursor synthesis, retro-transcription of RNA templates, and replication of single and double-stranded DNA molecules. The distribution of protein families associated with these activities across the three domains of life—Archaea, Eukarya, and Bacteria—adds layers of complexity to the narrative. While Archaea and Eukarya often share similar protein structures, structural biology shows homologous, but distinct, structures in Bacteria. On the other hand, viral polymerases emerge as a crucial part of genome replication and transcription. Their versatility, including RNA-dependent RNA polymerase, …

Taylor, Genealogy, History, Peter Hawes

Honors Theses

In this paper I compare two different genealogies of the idea of the ‘self’: Charles Taylor’s and Michel Foucault’s. I begin by arguing that Taylor’s focus on combating what he calls “subtraction stories” places him in the genealogical tradition with Foucault. I then engage with Foucault's genealogy of the self, which illuminates how the notion of the ‘self’ was constructed as a means of control, which leads him to say we should do away with trying to understand it outside of relations of power. This call for the rejection of the self, I suggest, presents a problem for us, who …

Assessing Evolution Of Reproduction Traits Along Seasonal Transitions And Latitudinal Gradients In An Invasive Species Of Fruit Fly, Zaprionus Indianus, Ansleigh Gunter

Honors Theses

This thesis examines the reproductive traits of Zaprionus indianus, an invasive species to the United States, to assess the possibility of rapid evolution. Significant differences in fecundity and diapause incidence have been seen in other Drosophilid fly species across the seasonal transition, from early to late season, and across the latitudinal gradient, from north to south. For this reason, fecundity, the reproductive ability of a female fly, and diapause incidence, a stress-induced reproductive arrest, were selected as variables of choice. Field collections and experiments revealed unexpected patterns in fecundity and diapause incidence, challenging initial hypotheses. While no significant differences in …

Heterocycles As Peptide-Based Cleavable Linkers, John Blobe

Honors Theses

As cancer cases continue to rise, the need for advancing the treatment options for cancer is ever increasing. Current cancer therapeutics, while effective at treating localized cancers and a fraction of advanced cancers, generally lack the specificity needed to target more advanced cancers. Recent advancements in cancer treatments have leveraged antibodies to target certain cancers. A class of drugs that utilize antibodies to deliver anti-cancer therapy preferentially to cancer cells, termed antibody-drug conjugates (ADCs), have been quite effective in treating certain advanced forms of certain cancers. These ADCs could be more effective if they could allow for the facile release …

Investigation Of Zinc And Iron In Wildflower Honey, Savannah Simpson

Honors Theses

Honey acts as a valuable food source for both animals and humans. When found in contaminated environments, there is an increased likelihood that honey samples will have high metal concentrations. It has been discovered that honey concentrations in metals can be different based on location. This experiment aims to determine the amount of two valuable metals, zinc, and iron, in various honey sources. These metals can be important to the human body because they help boost immunity and allow the body to carry out the functions required for survival. However, if these elements are present in copious quantities, then it …

Cannabis-Induced Psychotic Disorder And Schizophrenia Diagnostic Comparison, Tyanna Brodhagen

Honors Theses

Recent changes in cannabis legalization will have broad societal impacts for decades to come, not the least of which are the unknown consequences to neuropsychiatric health, particularly for adolescents and young adults. Cannabis-induced psychotic disorder (CIPD) is a controversial and poorly understood neuropsychiatric condition characterized by a psychotic experience brought on by excessive cannabis intoxication and/or withdrawal. Although CIPD is currently an uncommon diagnosis, the overlapping symptomology and comorbidity with schizophrenia indicates CIPD may be underdiagnosed. Some authors suggest the under diagnosis of CIPD may be correlated to physician diagnostic practices. This honors thesis constitutes a scholarly literature review and …

Acid Attack: How Escherichia Coli Strains Resist Acid Stress, Lindsey Miller

Honors Theses

The systems used by Escherichia coli to combat heightened levels of acidity within their environment are varied and complex. Four distinct systems used by E. coli to resist acid-induced stress were identified in 2004 by Foster (1), though six now are known today. These systems include the glucose-repressed, glutamate-dependent, arginine-dependent, lysine-dependent, ornithine-dependent, and serine-dependent acid resistance systems. Each system is also known by its corresponding abbreviation, AR1-AR6. What is known about each system varies due to identification date, complexity of the pathway, and amount of research completed. Within this paper, each system will be identified and the pathway defined, combining …

Biophysical Study Of The Von Willebrand Factor Via Optical Tweezers—Investigating The Collagen Binding Force Profile To Distinguish Types Of Von Willebrand Disease, Leigh Hardin

Honors Theses

von Willebrand disease (vWD) is a genetic disorder due to quantitative or qualitative abnormalities of the von Willebrand factor (vWF). There are three main types of vWD in addition to acquired von Willebrand syndrome. Type 1 is due to a deficiency of vWF, while Type 3 is due to a complete absence of vWF. Type 2 is due to malformed factors and broken into four subtypes: 2A, 2B, 2M, and 2N. Each subtype corresponds to different abnormalities of the protein that affect its binding to other proteins such as collagen, Factor VIII, platelets, etc. Therefore, determining a patient’s type and …

Hazards And Perceptions Of Cigarette And E-Cigarette Waste, Jossalyn Rogalski

Honors Theses

No abstract provided.

Violence Against Healthcare Workers, Nichole Osgood

Honors Theses

Workplace violence is any act or threat of physical violence, harassment, intimidation, or other threatening disruptive behavior that occurs at work (US Department of Labor, 2023). There are a handful of different types of workplace violence that include but are not limited to physical violence, verbal abuse and threats, sexual harassment, and psychological trauma (US Department of Labor, 2023). Workplace violence, a multifaceted phenomenon, is not a new concern, but its pervasiveness and intensity in healthcare settings have reached alarming proportions in recent years. In a meta-analysis, it was noted that workplace violence against healthcare workers of any kind was …

The Unexpected Significance Of Myosin A In Organization Of M-Line Protein Unc-89/Obscurin Within Striated Muscle Cells Of Caenorhabditis Elegans, Kar Men Lee

Honors Theses

This research investigates the unexpected significance of Myosin A in the organization of M-line protein UNC-89/obscurin within striated muscle cells of the nematode Caenorhabditis elegans (C. elegans). The study employs immunofluorescence techniques to examine the spatial and temporal dynamics of UNC-89/obscurin and Myosin A during embryonic development. The sarcomere, a fundamental unit in muscle cells, is governed by the 'sliding filament model,' where the M-line serves as a crucial anchor for Myosin A. This research seeks to understand the relationship between muscle function in humans and C. elegans, utilizing the latter's simple anatomy and genetic tractability. The …

Associations Between Internalization Of The Model Minority Myth And Burnout Among Asian College Students, Tu Truong

Honors Theses

Background. Burnout has become increasingly prevalent among college students in recent years. A potential risk factor for burnout among Asian and Asian American college students is internalization of the Model Minority Myth, for it may cause psychological distress within Asians. This study has two aims: 1) to examine the association between internalization of the Model Minority Myth (i.e., achievement orientation, unrestricted mobility) and burnout (i.e., exhaustion, cynicism, and efficacy) among Asian college students; and 2) to assess whether the association between internalization of the Model Minority Myth and burnout among Asian college students differs by international student status.

Methods. A …

We Are The Reason We Stand Still In The Face Of Climate Change., Sydney Hemp

Honors Theses

Many different factors can impact the way any information is received but it is especially important to see how scientific information is received because it is often backed up by a great deal of evidence, especially in the case of global climate change. Many of these factors have nothing to do with science and everything to do with social influences, political parties, and other demographic measures. Discussion of these relationships is important when discussing communication in a broad sense, but it can be even more important when bringing up things like global climate change, which has become a political topic …