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Investigation Of The Expression Of The Haesa Receptor-Like Kinase As Regulated By The Stm And Ath1 Homeodomain Transcription Factors In Arabidopsis Thaliana, Darby Raybourn

Honors Theses

Abscission, the shedding of plant organs, is a key process in plant development. Abscission takes place in highly regulated regions called abscission zones (AZ). ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1) and SHOOT MERISTEMLESS (STM) are organ boundary transcription factors that have previously been observed to play a role in sepal-stem boundary formation. Plants carrying mutations in both genes have flowers in which the sepal-stem boundary is abolished. The double mutant flowers are also observed to retain all floral organs. Because abscission zones in Arabidopsis form at organ boundary regions, we hypothesized that the STM and ATH1 transcription factors play a role …

The White-Nose Syndrome Transcriptome: Exploring The Putative Fungal Virulence Genes Of Pseudogymnoascus Destructans., Sophia Marie Reeder

Honors Theses

White-nose syndrome (WNS) in North American bats is caused by an invasive cutaneous infection by the psychrophilic fungus Pseudogymnoascus destructans (P. destructans). In a previous study, we used a dual RNA-Seq approach, which allowed us to gain insight into the gene expression of both the host and the pathogen simultaneously, and we observed differences in P. destructans gene expression that suggest host-pathogen interactions that might determine WNS progression. More recently we compared transcriptome-wide changes in gene expression levels in P. destructans grown on and actively infecting the wing of a bat (infecting pathogen) with P. destructans grown in culture (free …

Beautiful Minds : Exploring The Healing Potentional Of Self-Refexive Art In Facing A Campus Mental Health Crisis, Molly Chapman Rossi

Honors Theses

This interdisciplinary study of mental health seeks to do three things:

1. Identify and investigate the issue of mental health among students within the University of Richmond campus community, through both statistical and ethnographic data,

2. Apply trauma theory to redefine the crisis as a community trauma with unique aspects, and

3. Make a case for hope by proposing a plan that uses self-reflexive art, specifically theatre, to address the individualized community trauma and second-wave trauma.

I explicate new theories in this work, among them the notions of “individualized community trauma,” “second-wave trauma,” and “traumatic fusion.” Another critical concept is …

How Does One Child Policy Influence Chinese Household Saving Behavior, Yueyang Cao

Honors Theses

This paper investigates the influence the decline in the family size on household size through a Chinese family planning policy, the One-Child Policy (OCP). I find the evidence of the negative effect at the micro level using Chinese household survey data. I also study the aggregated effect using Chinese provincial level data. With the concern of endogeneity, I use a two-stage least square regression with financial punishments for having more than one child and share of population that were exempted from the restriction as instruments for the fertility variable. This regression shows a positive impact of the implementation of the …

Food Insecurity In Nepal : A Cross-Sectional Analysis From 75 Districts, Aarti Reddy

Honors Theses

There are a number of studies regarding food insecurity, but not many that investigate the simultaneous relationships between food insecurity and the measures of well-being (health, education and gender equality). This paper conducts a district-level cross-sectional analysis of the relationship between food insecurity and the measures of well-being in Nepal using an ordered probit model. Instrument variables are used in a two-stage analysis to address the problem of endogeneity. The study finds that health deprivation levels significantly affect levels of food insecurity in a district but education and gender literacy disparity are less significant. Addressing issues of endogeneity and multicolinearity …

Synthetic Flexibility Of A Bromopyrrole Ester Intermediate : Toward Novel Biologically Active Compounds, Scott Cameron Yeudall

Honors Theses

Compounds containing the pyrrole ring as a core structural motif continue to show significant biological activity, and both natural product derivatives and novel chemical scaffolds show potential for use as pharmaceuticals in treating a variety of cancers, infections, and inflammation. Given the widespread and important applications of compounds containing this motif, novel, rapid, and selective methods for the synthesis of multifunctional pyrroles is of some importance. Previous work in our group has utilized palladium-mediated Suzuki cross-coupling as a powerful tool for functionalizing activated bromopyrrole esters, generating structural analogues of bioactive natural products. We have also used a similar approach to …

Computational Studies Of Paradifluorobenzene Cations And Hydrogen Cyanide Molecule, John C. Rowe Iv

Honors Theses

Polycyclic aromatic hydrocarbons (PAHs) are hypothesized to comprise a significant portion of interstellar carbon identified from the Diffuse Interstellar Bands (DIBs). Gas phase cation-molecule reactions between compounds that previously existed as weakly bound species provides the best explanation for the emergence of PAHs in the interstellar medium (ISM). In this work, we use computational methods to characterize one of these weakly-bound systems. We discovered that intramolecular charge distribution (calculated using the Natural Population Analysis) dictate the complexes formed between a paradifluorobenzene cation and either one or two HCN molecules. Additionally, the relative stabilities of the complexes and the binding energies …

Characterization Of Catecholamine Receptors And Transporters In Murine Macrophages, Elizabeth Gonye

Honors Theses

Macrophages are a critical part of the immune response. When circulating monocytes move into tissues they differentiate int macrophages to mount the first line of defense against pathogens.

Calcium (Ii) Catalyzed Nitrone Additions, Elizabeth A. Congdon

Honors Theses

Calcium(II) complexes have be shown to be successful catalysts for nitrone reactions. The addition of n-­‐methyl and n-­‐phenyl nitrones to donor-­‐acceptor cyclopropanes was achieved with calcium triflate (Ca(OTf). Differentially substituted tetrahydro-­‐1,2-­‐oxazines were synthesized in good to excellent yields. Calcium triflate was also found to catalyze the addition of silyl enol ethers to n-­‐phenyl nitrones along the Mukaiyama-­‐Mannich addition pathway. B-­‐amino carbonyls were synthesized from a variety of substituted nitrones. Bulky and cyclic silyl enol ethers were also found to be reactive, the products of which were isolated in good to excellent yields.

Impact Of Vector Range Expansion On Pathogen Transmission Dynamics Of Lyme Disease In Southwestern Virginia, Bishan Bhattarai

Honors Theses

Blacklegged ticks, Ixodes scapularis is the primary vector of Lyme disease in eastern United States. Borrelia Burgdorfei, the etiological agent of Lyme disease is transferred by ticks of Ixodes species. In recent years, its congener, Ixodes affinis has been expanding its range northwards from its southern population. We were interested in studying how the introduction of this new vector affected the interaction between the pathogen genotype and the host. We hypothesized that differential host use by I. affinis and I. scapularis would partly explain observed differences in B. burgdorferi infection prevalence and genotypic structure in southeastern Virginia. The result …

A More Perfect Union? An Analysis Of Schuette V. The Coalition To Defend Affirmative Action And Minority Group Rights In Multicultural Democracies, Robert Barber

Honors Theses

In 2006, the State of Michigan passed Proposal 2, an amendment to the Michigan Constitution which effectively banned affirmative action and race-conscious admissions policies at Michigan's public universities. Despite arguments that this policy placed an undue burden on certain ethnic and racial minorities by suppressing their participation in the American political process, the U.S. Supreme Court upheld Proposal 2 as constitutional in the 2014 case Schuette v. Coalition to Defend Affirmative Action. This thesis seeks to argue for the necessity of restoring the access to political participation removed with the passage of Proposal 2, as well as present a convincing …

The Application Of Rna Interference To Knock Out Groucho Expression In Drosophila S2 Cells, Savannah Mitchell

Honors Theses

The development of a complex nervous system requires the actions of intricate genetic mechanisms that influence and maintain the differentiation of common nervous system progenitor cells into neurons and glial cells. In Drosophila melanogaster, the gene glial cells missing (gcm) encodes the transcription factor Gcm that, when active, causes early nervous system cells to preferentially differentiate into glial cells by activating the reversed polarity (repo) gene, as well as others. However, the Gcm protein also plays a role in the differentiation of both macrophages and tendon cells. This suggests that there are other transcription factors or cofactors that interact with …

Terpenes And Flavonoids From Salvia Apiana And Their Affinities To Cannabinoid And Opioid Receptors, Taylor Hayes

Honors Theses

Salvia apiana (white sage, Lamiacae family) plant is native to southern California and parts of Mexico. Some Native American tribes local to this region consider S. apiana to be sacred and burn the leaves as incense for purification ceremonies. The plant has been used to treat sore throats, coughs, chest colds, upper respiratory infections, and poison oak rashes. Native Americans widely used this plant in traditional Chumash healing. Infusion of the leaves is used as a diaphoretic and diuretic. The aqueous ethanolic extract of S. apiana showed moderate activity towards the CB1 receptor (58.3% displacement). The extract was fractionated on …

Anatomical Locality On Haptic Feedback To Attenuate Stuttering, Travis Fortin

Honors Theses

Purpose The purpose of this study was to investigate whether a change in the location of the tactile stimulator would alter the instances of stuttering. Method Each subject was required to read a randomly assigned 300-syllable passage in each of the five assigned speaking conditions, which includes the control, fingers, chest, wrist, and foot. Results The stuttering count for each condition was analyzed by two trained research assistants. The median for the control was 44 syllables, the fingers were 41 syllables, the chest was 35 syllables, the wrist was 44 syllables, and the foot was 23 syllables. An RM-ANOVA was …

Cultural Implications Of Starbucks Consumption In China: Why Do Chinese Have A Latte On Their Mind?, Garrett Hersh

Honors Theses

The aim of this thesis was gain a more comprehensive understanding concerning the Chinese consumers understanding of coffee and Starbucks in China as a luxury good. Considering China's recent history, as well as the introduction of a capitalist, consumer economy, examining the Chinese consumers' consumption pattern of this foreign, arguably luxury, good, is reflective of Chinese consumer ideals. A literature review analyzing the relationship between Chinese consumer ideals and the introduction of global consumerism, in addition to a set of interviews and surveys were conducted in attempts to understand the current Chinese consumption patterns of Starbucks coffee. After conducting the …

3d Systems: An In-Depth Look Into The Past, Present, And Future Of 3d Printing, John Lars Ely

Honors Theses

This thesis revolves around the 3D printing industry. I focused the majority of my research on the company, 3D Systems. I looked into the various factors that are holding the company back and what it can do to overcome then. I concluded that 3D Systems needs to focus more on developing and marketing printers for the domestic market. I also found that the company has to gain a stronger foothold in the Asian market if it wants to emerge as the leader of the industry.

The Technician Behind The Artist: Where Science Meets Art, Joella Vaughnn

Honors Theses

The thesis has two purposes: to evaluate the difference between oil, acrylic, gouache, and encaustic paint for the purpose of glazing and to integrate engineering and artistic principles into this thesis. My final evaluation across the four paints is that oil has the highest performing glaze. I believe it is the best glazer because time is not a constraint for me as an artist. If an artist has a time constraint on their painting, I recommend using acrylic mixed with an acrylic polymer medium as a glaze because the drying time is much faster than oil. I discovered that gouache …

The Evolution Of The Vampire Other: Symbols Of Difference From Folklore To Millennial Literature, Kate Buckley

Honors Theses

With its roots in Eastern Europe and rapidly spreading to Western society in the past few hundred years, the vampire has served as a double for humanity, with the division of self between monstrosity and the human ideal. Vampires in folklore and literature have been a means by which human cultures have identified concepts of human subjectivity (identity), particularly with regard to what various societies have defined as monstrous (being Othered) within human nature. This study examines how the vampire character evolves throughout the centuries, with a specific focus on the less monstrous contemporary vampires who form hybrid communities with …

The Impact Of Survival Processing And Collaborative Inhibition On Memory Performance, Lindsey Hardin

Honors Theses

This study examines the effects of survival processing and collaborative inhibition on memory performance. The purpose of this research is to determine whether survival processing produced more accurate memory recall than pleasantness processing, as well as determine the impact of collaborative inhibition when compared to nominal groups. In this experiment, participants were given the instructions to rate a given list of words based on survival or pleasantness depending on which scenario they were assigned to. Then, the participants recalled the list of words in either collaborative groups or nominal groups. The results indicated that the survival condition did produce better …

The Synthesis Of Substituted Pentadentate Ligand Scaffolds And Their Future Application In Ruthenium-Catalyzed Water Oxidation, Manpreet Singh

Honors Theses

Rising global energy demands coupled with depleting natural resources have led to a strong emphasis on finding new sources of energy that are renewable and which limit the negative impact on the environment. One of the strongest candidates is utilizing solar energy to drive water oxidation to produce hydrogen as a fuel source. In order to do this, a better understanding of the mechanism involved in this process must be revealed. Homogenous molecular catalysts allow mechanistic studies and can be also used in Photoelectrochemical Cells (PECs) and other systems to produce chemical fuels. In this work, the new syntheses of …

Methods Of Quantification And Characterization Of Coccidian Oocysts, Mariam Abunemeh

Honors Theses

Coccidiosis is a major economic and health risk in the poultry industry. The oocysts of the causative agent of coccidiosis are excreted in animal feces and must be ingested by a new host for a new infection to begin. These oocysts are microscopic and very similar between species. The ability to quantify and identify the oocysts that are causing the illness is important to controlling this disease. My research first compares methods of quantifying oocysts of domestic turkeys for their ease of use and accuracy. Next, I attempt to identifying novel oocysts from a different turkey species by morphological and …

The Evolution Of The Sugarcoated American Food Market And The Paradox Of Artificial Sweeteners, Mary Moses Hitt

Honors Theses

Living in present-day America makes it hard to imagine an era when sugar was not as inexpensive and readily available as it is now. It is in little colorful packets on restaurant tables, filled to the brim in jars at coffee shops, or mixed into candy products located at the beginning of every cash register. Today, sugar is one of, if not, the most widely consumed food products in the world, but our love for sugar is nothing new. Humans have been experiencing the bliss triggered by sweet-tasting foods since their earliest diets, which included fruits and honey. Our diets …

A Comparison Of Warm-Up Modalities On Upper Body Force Production Measures, Mary G. Langford

Honors Theses

Warm-ups are often initiated before an athletic event in order to prepare the athlete's body for competition by increasing blood flow to the working muscles. When a warm-up also activates nerve-muscle function, producing a level of high-intensity power even after the muscle contraction occurs, it is known as post-activation potentiation (PAP). Most PAP warm-ups include high-load, low-velocity conditioning contractions whereas a low-load, high-velocity conditioning contraction may be a more user-friendly warm-up. Therefore, the purpose of this study was to investigate the effects of PAP after low-load, high-velocity conditioning contractions on subsequent upper body power exercises. Ten recreationally trained males (age: …

Restraining Order, Michael Martella

Honors Theses

This thesis is a collection of poetry and creative non-fiction that examines the intersection of place and environment with personal identity. Here are pieces written about sex, anxiety, beauty, death, masculinity, violence. But ultimately, this is a collection derived from and dependent on love.

In Six Days: The Creation Study Committee And The Pca's Struggle For Consensus On Anti-Darwinism, Michael Calhoun Wilkerson

Honors Theses

This thesis explores the historic struggle and development of the American Evangelical community to form a unified front against naturalistic evolution during the twentieth century: focusing on the Presbyterian Church in America (PCA) as a microcosm in the battle for a general consensus. Conservative six-day creationists who felt threatened by more liberal views within the denomination over the issue pressured the 1998 PCA General Assembly to appoint a special Creation Study Committee. The outcome of the work of the committee only broadened acceptable views within the denomination, much to the chagrin of the conservative elders who pushed for the Committee's …

The Effect Of Level Of Democracy In Importing States On Global Arms Transfers, Including A Case Study On France, Cody R. Bradford

Honors Theses

Cody R. Bradford: The Effects of Level of Democracy in Importing States on Global Anns Transfers, including a Case Study on France (Under the direction of Michèle Alexandre)

The Roles Of Introduced Eucalyptus In The Conservation And Expansion Of Ethiopian Orthodox Church Forests In The Northern Ethiopian Highlands, Janice Liang

Honors Theses

Species of the genus Eucalyptus (common name eucalyptus) are widely planted all across Ethiopia – including on large areas of land previously allocated to food production. In recent decades eucalyptus has also increasingly been planted on lands around and within “church forests,” sacred groves of old-aged Afromontane trees surrounding Ethiopian Orthodox Tewahido churches. These revered holy sites have long been recognized for their cultural values and also for their ecosystem services – including their potential to support species conservation and restoration, as church forests are some of the only remaining sanctuaries for many of Ethiopia’s indigenous and endemic plant and …

Redox-Sensitive Block Copolymer Nanoparticle Preparation And Characterization, Mary Virginia Portera

Honors Theses

The purpose of the research conducted in this project was to add to a wealth of knowledge concerning chemotherapy. Although chemotherapy has been used since Paul Ehrlich's discover of Salvarsan's ability to kill Treponema pallidum (the bacterium that causes syphilis), today the term chemotherapy is mostly used in conjunction with cancer treatment. There have been many successful chemotherapy drugs produced throughout the years, but a constant problem with chemotherapy is the fact that it also affects noncancerous cells. The topic of this research investigated targeted drug delivery systems that incorporate paclitaxel, a hydrophobic chemotherapy drug. This research mainly focused on …

Personality Correlates Of Cardiovascular Reactivity, Sara Bolen

Honors Theses

Neuroticism is a personality trait characterized by one's susceptibility to experience negative emotions, such as loneliness, self-consciousness, sadness, and worry. Neuroticism also has been found to be linked to blunted cardiovascular reactivity, which in turn has been shown to be associated with negative health outcomes, such as stroke or heart disease. The present study examined 50 undergraduate females at the University of Mississippi in order to examine the relationship of neuroticism and cardiovascular reactivity rates during a stressful speech task. Heart rate (HR) and blood pressure (BP) levels were recorded during rest and the stress periods, and neuroticism levels were …

A Neural Network Approach To Handwriting Recognition In The Codex A, Eleanor C. Anthony

Honors Theses

In this research, an attempt to create a neural network classifier for the Latin uncial alphabet found in the Codex A, a late fourth century manuscript held by the Archivo Capitolare in Vercelli, Italy and the oldest of the Latin Gospels, is outlined. Training data collection methods, as well as image processing and artificial data creation methods used for expanding the training set, are discussed, as is their contribution to the success of the neural networks. While successful results are achieved for the testing sets, classification of new image data is largely unsuccessful. Potential improvement and avenues for expanding the …