Digital Commons Network^™

Bridging The Lab-To-Clinic Gap In Intranasal Nanomaterial-Based Chemotherapy For Glioblastoma, Sophia Leslie, Stella Rios, Hana Elnahas, Megan E. Keniry

School of Integrative Biological & Chemical Sciences Faculty Publications

Clinical outcomes for brain cancer are often poor because the blood–brain/tumor barrier hinders effective drug delivery to malignant tissue. Glioblastoma, the most common primary brain malignancy in adults, has an average survival of approximately fourteen months. Here, we discuss novel strategies that our research group and others are developing to deliver chemotherapy to the brain via the nasal cavity. Although significant hurdles remain, intranasal delivery holds substantial promise for improving outcomes for patients with brain cancer. Intranasal delivery is noninvasive, permits repeated dosing, and has been shown to enable direct nose-to-brain transport that bypasses the blood–brain barrier. Challenges such as …

Metabolomic Characterization Reveals Organ-Specific Accumulation Of Secondary Metabolites In Petiole Glands Of Idesia Polycarpa, Fangming Liu, Xingyue Xiong, Yanmei Wang, Li Dai, Zhi Li, Xiaodong Geng, Juan Wang, Yongyu Ren, Qifei Cai, Zhen Liu

Michigan Tech Publications

Background/Objectives: Idesia polycarpa Maxim. possesses conspicuous glandular protuberances on its petioles, but the chemical composition and potential biological significance of these structures remain largely unexplored. This study aimed to characterize the metabolic profile of I. polycarpa petiole glands and to determine their organ-specific accumulation patterns of secondary metabolites compared with leaves and shoot tips. Methods: A widely targeted metabolomics approach based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was applied to analyze petiole glands, leaves, and shoot tips collected from the same I. polycarpa individuals. Multivariate statistical analyses and differential metabolite profiling were performed to compare metabolic characteristics among …

Biallelic Variants In Kmo Cause A Novel Form Of Congenital Nad Deficiency, Seema R Lalani, Jill A Rosenfeld, Varduhi Petrosyan, Aleksandar Milosavljevic, Angelina Gaspero, Denise G Lanza, Audrey E Christiansen, Amrit Koirala, Abu Hena Mostafa Kamal, Nagireddy Putluri, Cristian Coarfa, Bao Tran, Philip L Lorenzi, Lin Tan, Charul Gijavanekar, Sarah H Elsea, Emily Lawrence, Hartmut Cuny, Sally L Dunwoodie, Pengfei Liu, Haonan Zhouyao, Tara L Rasmussen, Mary E Dickinson, Carlos A Bacino, Brendan Lee, Ronit Marom, Undiagnosed Diseases Network, Bcm Center For Precision Medicine Models, Jason D Heaney, Chih-Wei Hsu, Lindsay C Burrage

Faculty, Staff and Students Publications

Congenital NAD deficiency disorder (CNDD) is a gene × environment disorder caused by disruptions of the kynurenine pathway. To date, CNDD has been associated with biallelic variants in three kynurenine pathway genes: KYNU, HAAO, and NADSYN1 . We identified two sisters with congenital anomalies overlapping with CNDD who have biallelic variants in a gene encoding a different kynurenine pathway enzyme, KMO . The surviving child also has elevated levels of metabolites upstream of KMO with low NAD + levels in plasma, suggesting that KMO deficiency is a novel CNDD. To explore the pathogenicity of KMO deficiency, we generated a global …

Two New Species Of Liodessus Diving Beetles From Costa Rica (Coleoptera, Dytiscidae, Bidessini), Michael Balke, David Bilton, Monika Springer, Adrián Villastrigo, Katja Neven, Lars Hendrich

School of Biological and Marine Sciences

Two new species of the diving beetle genus Liodessus Guignot, 1939 are described from Costa Rica: Liodessus quetzalicus sp. nov. (central valley as well as the high-mountain Páramo region, 1,380–2,800 m) and L. cerrodelamuerte sp. nov. (> 3,000 m). The species are delineated based on morphological characters, including male genitalia as well as beetle size, shape and colour pattern. The habitats are described in detail. Altogether 18 species and 10 additional subspecies of Liodessus are now recorded from higher mountain regions in Central and South America.

Socioeconomic Determinants Of Malaria Infection Among Pregnant Women In Cameroon, Sub-Saharan Africa, Arnold Akosah Muluh

Walden Dissertations and Doctoral Studies

Malaria during pregnancy is a significant public health issue in Cameroon, affecting maternal health and birth outcomes. Despite preventive measures, disparities exist among socioeconomic groups and between urban and rural areas. The study was guided by the social-ecological model and explored how socioeconomic factors and geographic location influence malaria infection in pregnant women. Specifically, the impact of wealth index, maternal education, and healthcare access on infection rates, considering maternal age, parity, and residence, was examined. Quantitative data from the Cameroon DHS Phase 8 were used (N=1204). The sample included pregnant women with valid malaria test results. Chi-Square tests and binary …

Staff Education To Strengthen Patient Counseling For Recurrent Uti Prevention In Middle-Aged And Older Women In A Low-Income Community Clinic, Linda Osamede Isidienu

Walden Dissertations and Doctoral Studies

This doctor of nursing practice (DNP) project was a practice-focused quality improvement (QI) staff education initiative designed to address recurrent urinary tract infections (UTIs) among middle-aged and older women receiving care in a low-income community clinic. Recurrent UTIs are associated with increased antibiotic use, antimicrobial resistance, and reduced quality of life. The purpose of this project was to evaluate whether a structured staff education program could improve provider knowledge related to patient counseling on UTI prevention. Twenty nurses and medical assistants participated in the intervention, which included education on evidence-based prevention strategies, counseling techniques for low health literacy populations, and …

The Relative Strength Of Compulsive Reward-Driven Eating, Weight Self-Efficacy, And Physical Appearance Comparison In Predicting Feelings Of Self-Worth, Kathleen Rowe

Walden Dissertations and Doctoral Studies

Walden University College of Psychology and Community Services This is to certify that the doctoral dissertation by Kathleen Rowe has been found to be complete and satisfactory in all respects, and that any and all revisions required by the review committee have been made. Review Committee Dr. Hedy Dexter, Committee Chairperson, Psychology Faculty Dr. Medha Talpade, Committee Member, Psychology Faculty Chief Academic Officer and Provost Sue Subocz, Ph.D. Walden University 2026

Guided Tissue Regeneration Of Localized Deep Combined 2-To-3- Wall Angular Defects: A Clinical Case Report With 15-Month Follow-Up

Journal IDA

Periodontitis is a chronic inflammatory disease affecting nearly 50 percent of U.S. adults. It is characterized by the irreversible destruction of the alveolar bone, periodontal ligament, and gingival tissues supporting the teeth. Periodontal breakdown results from a dysbiotic relationship between the plaque bacteria and host-immune response. Initiated by the bacterial plaque biofilm, the once normal and homeostatic host defenses intended to contain the subgingival inflammation become dysregulated and hyperactive. A diagnosis of an infrabony defect, also known as intrabony, vertical, or angular defects, is made when the base of the pocket is apical to the alveolar crest. It has been …

Diagnostic Challenge: Oral Pathology

Journal IDA

The challenge: We present a case of a 27-year-old female patient who presented to the Fritts Screening Clinic at Indiana University School of Dentistry. She takes metformin for pre-diabetes and levothyroxine for hypothyroidism. Her extraoral exam reveals no pathologies. The intraoral clinical examination reveals a non-wipeable unifocal hyperkeratotic papillary lesion measuring 0.8 x 0.5 cm on the left lateral border of the tongue (Figure 1). The patient reports noticing it approximately a month before the screening appointment; however, she did not experience any pain or other symptoms in the area. An excisional biopsy is performed to obtain a definite diagnosis …

Role Of Microsurgery In The Evolution Of Periodontal Surgery

Journal IDA

Microscopes and microsurgery techniques have revolutionized the field of periodontology, offering enhanced visualization, precision, and improved clinical outcomes. This review explores the role of magnification in periodontal treatments, the benefits of microsurgical techniques, and their impact on patient recovery and procedural success. It examines how these advancements align with evolving surgical principles and addresses their implications for clinical practice and patient outcomes. By integrating microsurgery into periodontics, clinicians can achieve minimally invasive procedures with superior aesthetic and functional results. This paper also discusses the challenges and future directions of microsurgical applications in periodontics, emphasizing the importance of continual advancements and …

Recent Advances In Periodontology

Journal IDA

Periodontology is a dynamic discipline focused on the prevention, diagnosis, and treatment of diseases affecting the supporting structures of the teeth and dental implants. Given the complex and multifactorial pathogenesis of periodontal and peri-implant diseases, the field continually evolves to address diverse clinical needs through evidence-based innovations. Recent years have witnessed significant advances in biomaterials, biologics, diagnostic tools, and minimally invasive therapies that have transformed the clinical management of periodontal conditions. These developments aim not only to improve treatment efficacy and patient outcomes but also to expand the scope of regenerative and patient-centered care. The purpose of this paper is …

Meet Dr. Rebecca De La Rosa, 2025-26 Ida President

Journal IDA

The News & Features column brings the latest information impacting members of the Indiana Dental Association.

Journal Ida 2025 104 2

Journal IDA

In the Spring 2025 issue, the reader will find the following feature articles:

• Teaching the Next Generation: Challenging the Narrative and Shifting Perspectives
• Recent Advances in Periodontolgy
• Role of Microsurgery in the Evolution of Periodontal Surgery
• Diagnostic ChallengeL Oral Pathology
• Factor V Lieden Heterozygosity and Hypertriglyceridemia in 88 Patients with Chronic Jaw Pain and Alveolar Osteonecrosis
• Guided Tissue Regeneration of Localized Deep Combined 3-to-3 Wall Angular Defects: A Clinical Case Report with 15-Month Follow-up

This issue also includes regular columns from the editor, the executive director as well as membership news.

Journal Ida 2025 104 1

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2024 103 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2024 103 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2021 100 2

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2020 99 4

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2020 99 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Journal Ida 2019 98 3

Journal IDA

The Journal IDA is a peer-reviewed, scientific periodical owned and published by the Indiana Dental Association, a constituent of the American Dental Association.

Journal IDA concentrates on the clinical aspects of dentistry, including case studies and research; practice management and business aspects of dentistry, from start up to transition; and also includes special and regular feature articles.

Distribution Of Urinary Calculi And Its Association With Clinical And Laboratory Findings In Dogs And Cats With Stone Analysis At Chulalongkorn Animal Teaching Hospital, Thailand (2020-2024), Tanattha Ladabornvidhaya, Natkrita Baikloy, Theaparak Thipjaroen, Parapond Kongrakchang, Warisara Kaechaiya, Sumonwan Chamsuwan, Monkon Trisiriroj, Chollada Buranakarl

The Thai Journal of Veterinary Medicine

Urinary calculi are commonly encountered in veterinary practice; however, information regarding their distribution of stone that underwent analysis and associated clinical findings remains limited. This study investigated the distribution of urolithiasis and the associations between stone types and clinical and laboratory findings in dogs and cats presented to the Chulalongkorn Small Animal Teaching Hospital between 2020 and 2024. The three most common stone types in both species were calcium oxalate (CaOx), struvite, and urate, with relatively stable trends over the 5-year period. Small-breed dogs had a higher risk of developing CaOx urolithiasis than medium-breed dogs (OR = 10.4, 95% CI …

A Review On Traditional And Modern Aspects Of Vitex Negundo L.: Ethnomedicine, Phytochemistry, And Pharmacology, Tathagata Khanra, Suvasish Mitra, Subham Saha, Maitryee Mondal, Subhash C. Mandal

International Journal of Traditional Knowledge

Vitex negundo L., or five-leaved chaste tree, is a medicinally significant plant widely distributed in Asia and other tropical regions, frequently utilized in traditional healing systems for a spectrum of ailments. This comprehensive review consolidates current knowledge on the botany, traditional uses, phytochemical constituents, and pharmacological potentials of Vitex negundo L. The plant is rich in diverse bioactive compounds such as flavonoids, alkaloids, glycosides, and terpenoids, which are primarily responsible for its multidimensional therapeutic actions. Scientific investigations have substantiated its role in exerting anti-inflammatory, analgesic, antimicrobial, antioxidant, hepatoprotective, nephroprotective, insecticidal, anticancer, and antidiabetic effects, among others. Research reveals promising enzyme-inhibitory, …

Siddha Formulations: A Traditional Reservoir Of Valuable Medicines For The Contemporary World, Agnes Preethy

International Journal of Traditional Knowledge

Traditional Medicine had been practised for many centuries in different parts of the world. However, the deep insights drawn from the traditional knowledge have remained highly localized as it had been privy only to the generations of traditional medicine practitioners. This, combined with lack of scientific evidence of their therapeutic action, had limited access, acceptance and awareness of these preparations to the larger segment of the community. The emergence of new lifestyle disorders and drug-resistant diseases in recent years has fuelled the search for alternate treatment strategies and has revived interest in traditional medicines. Concerted efforts to decipher the molecular …

Ayurvedic Herbs In The Management Of Benign Prostatic Hyperplasia: A Comprehensive Narrative Review, Latha Damle, Chandrasekhar C

International Journal of Traditional Knowledge

Benign Prostatic Hyperplasia (BPH) is a common, non-cancerous enlargement of the prostate gland, primarily affecting older men. It frequently leads to lower urinary tract symptoms (LUTS) such as increased urinary frequency, urgency, nocturia, and weak urine flow, which can significantly impair quality of life. Standard treatments for BPH include alpha-blockers, 5-alpha reductase inhibitors, and surgical interventions. However, limitations in efficacy and potential adverse effects have driven interest in complementary and traditional therapies, including Ayurveda. In Ayurvedic medicine, BPH is described as Mutraghata and Vatashthila, conditions attributed to an imbalance of Vata and Kapha doshas that disrupt normal prostate and …

Unveiling The Night-Flowering Jasmine: A Comprehensive Review Of Nyctanthes Arbor-Tristis’ (Oleaceae) Phytochemistry, Ethnomedicine, And Therapeutic Potential, Subham Saha, Soumya Mitra, Tathagata Khanra, Saban Karmakar, Tamalica Hore, Subhash C. Mandal

International Journal of Traditional Knowledge

Nyctanthes arbor-tristis (NAT), typically known as Night-flowering Jasmine or Harsingar or Parijat, is one of the prominent medicinal plants indigenous to the Indian subcontinent. Its application dates back to ancient times, with substantial documentation in former religious texts. Native communities have traditionally used this for various human ailments and as an ornamental plant. Leaves, flowers, seeds and stems of this plant are rich in various primary and secondary metabolites, providing a wide range of pharmacological effects. The most abundantly found phytoconstituents belong to iridoid glycosides, such as arbortristosides. Comprehensive research has investigated its potential in anticancer, antiviral, and anti-inflammatory activities, …

Gaining From Captured Indian Traditional Knowledge Systems: Paths Taken And Way Forward, Ramasami T

International Journal of Traditional Knowledge

India’s scientific heritage is deeply reflected in Ayurveda, a tradition of integrative medicine documented for over two millennia. P.C. Ray, the father of modern chemistry in India, highlighted the depth of ancient chemical knowledge and early use of mercury compounds, while M.S. Valiathan later revived and analyzed the classical texts of Charaka, Sushruta, and Vagbhata to bridge Ayurveda with modern science. Building on this foundation, the Government of India launched initiatives linking Ayurveda with genomics, personalized medicine, and rasayana therapies, yielding promising insights such as the genetic basis of prakriti classifications and protective effects of Amalaki Rasayana. Efforts like the …

Advancing Clean Mobility: Hydrogen Fuel Cell Electric Bus Workforce Development For Transit Agencies, Manideep Tummalapudi, Shantanu Kumar, Jaskaran Singh

Mineta Transportation Institute

Hydrogen fuel cell electric buses (FCEBs) are rapidly transforming public transportation in the United States. However, while transit agencies are investing heavily in new zero-emission vehicles and fueling infrastructure, far less attention has been paid to the workforce needed to operate and maintain them. As agencies accelerate toward ambitious climate and fleet transition goals, they are also confronting a critical challenge: preparing workers for an entirely new set of technologies, safety requirements, and operational demands. This study addresses that gap by systematically identifying the knowledge, skills, and abilities (KSAs) required for FCEB vehicle operators and maintenance technicians, assessing current training …

Noyce Program Provides Iwu Stem Students With Mentorship And A National Teaching Community, Emily Bollinger

Press Releases 2020-2029

No abstract provided.

Connecting Families Through Cash Transfers And An Enabling Environment In Colombia, Mexico, And The Philippines: A Qualitative Study, Johanna K P Greeson, John Gyourko, Sarah Wasch, Kristin Mallory, Lory Fehlig, Cesar Jácome, Nestor David Lara Yanes, Fátima Areli Ruiz Gutiérrez, Dennis Guamos, Adele R. Lehman

Faculty Scholarship

Nearly 700 million people worldwide live in extreme poverty, and almost half of the world’s population lives below the poverty line. Cash transfer programs are increasingly used to address poverty’s effects on family well-being, yet less is known about how families experience programs that combine cash transfers with peer-driven mutual aid. Children International’s (CI) Community Independence Initiative (CII) provides conditional cash transfers and promotes family-led goal setting, mutual support, and shared learning. This qualitative study explored how families in Colombia, Mexico, and the Philippines experienced CII and made meaning of its material and relational components. We conducted focus groups with …

Long-Term Trends And Drivers Of Commercial Shrimp Fisheries Across The Southeastern U.S. Atlantic Coast, Trinity Assels

Electronic Theses and Dissertations

Long-term dynamics of southeastern U.S. Atlantic commercial shrimp fisheries reflect interacting environmental and socioeconomic processes rather than uniform regional decline. However, integrated, multi-state assessments linking these drivers to fishery-dependent indicators remain limited for the region. This study analyzed over four decades (1980–2023) of confidential fishery-dependent data from coastal South Carolina, Georgia, and northeastern Florida, focusing on the region where white and brown shrimp dominate commercial landings. Segmented regression analysis was used to identify structural shifts in long-term trends of landings, participation, and catch-per-unit-effort (CPUE), while multiple linear regression models identified seasonal temperature variables associated with interannual variation in shrimp CPUE. …