Digital Commons Network^™

Albinism In Africa: Examining Identity Formulation, Corinne Tinkham

Honors Theses

Albinism is a genetic condition that often intersects at disability and perceived notions of race; this double-stigmatization has proved problematic for people with albinism living in Africa, who not only appear physically different from others in their community but are also commonly regarded as ontologically different. Individuals with albinism in Africa undergo frequent challenges throughout their lifetime that significantly shape their identities. This process of identity formation begins in early childhood and is greatly impacted by unequal access to healthcare and schooling, harmful rumors and mythologies surrounding the condition’s origins, violence, workplace discrimination, income inequality, and many other factors. In …

Understanding Shear Thinning Using Brownian Dynamics Simulation, Mackenzie Nicole Wall

Honors Theses

In this work, we study the changes in structure during the shear thinning regime using Brownian Dynamics with a simple steady-state shear flow of binary charged colloidal suspension. Previous research has analyzed the viscosity, radial distribution, elasticity and plasticity of materials with rheo-SANS experimentation; however, less research has been conducted to replicate the experiment through computer simulations. With Brownian Dynamic Simulation, this study was able to reproduce the results obtained in a recent rheo-SANS experiment and it also explored the viscosity, radial distribution, elastic and plastic behavior of a system under different parameters. The comparison of simulated data with experimental …

The Effect Of The Apolipoprotein A1 (Apoa1): The Stability And Folding In Potassium Chloride Environment, Alexandra Paladian

Honors Theses

Healthy levels of potassium chloride (KCl) can significantly affect the workings of the cholesterol level of the human body and how they pertain to an individual person. The search for a better salt additive for the human diet can provide a better option for people who experience high cholesterol levels and heart disease. The study focuses on the experimental design of the Molecular Dynamic (MD) simulation of the Apolipoprotein A1 (APOA1) in the potassium ion solution environment to determine the stability and folding of the protein. The study also compares its data to the previous experimental design of chloride ions …

Troglofauna Of Van Buren And White County: A Survey Of Four Caves In The Mideastern Cumberland Plateau, Gavin Page

Honors Theses

The Cumberland Plateau in Tennessee has the highest cave-obligate biodiversity in North America. Cave-obligate species are entirely restricted to subterranean habitat and demonstrate unique troglomorphy. These species are categorized as troglobionts. However, because of their isolated occurrences, theses species are vulnerable to a variety of disturbances. This issue is furthered in the fact that only approximately 7% of the caves in this region have been surveyed. Of these caves that have been surveyed, only a small portion were professional entomological surveys, while almost no cave has ever been extensively repeat sampled. This study involved newly sampling one cave and repeat …

Increasing Stress Tolerance In Saccharomyces Cerevisiae Using Lipocalin Genes, Ximena Leon

Honors Theses

Saccharomyces cerevisiae is a microorganism that is commonly used in industries, but its productivity is significantly hindered by its inability to resist high stress levels found in industrial processes. By increasing stress tolerance in S. cerevisiae, its role in industrial processes could be maximized. The objective of this study is to determine if complementation of lipocalin genes into the wildtype and knockout strains of S. cerevisiae can increase stress tolerance against a variety of stressors. We identified the knockout yeast strains, ALD3, ALD4, PDX3, and ILV1, as being sensitive to various stressors including salinity, heat, oxidative, and osmotic stresses. Arabidopsis …

Molecular Dynamic Simulation Of The Complex Folding Patterns Of Apolipoprotein A1 In Various Concentrations Of Potassium Chloride, Hannah Holmberg

Honors Theses

Apopliprotein or ApoA-1 is a complex lipoprotein that functions in the removal of cholesterol from the blood, removing cholesterol from the area around white blood cells and promoting the excretion of lipids through the lymphatic system. Previous research has found that ApoA-1 shows both folded and unfolded conformations depending on the concentration of NaCl in solution in the water around it. The protein was studied using molecular dynamics simulations. Once this state of equilibrium was reached, various structural properties of the protein were measured including the radius of gyration and the radial distribution function. The goal of the project was …

The Effects Of Urbanization On Insect Morphology: A Meta-Analysis, Evann L. Bailey

Honors Theses

Urbanization has been shown to create a rapid change in the environment as you move from rural areas to urban areas. It can create a multitude of effects on the environment. Some examples include, land disturbance, pollution, increasing temperatures and a disturbance in vegetation and biodiversity. Insects are useful organisms that provide maintenance and upkeep for ecosystem functioning. The rapid development of urbanization and how it is changing the environment may impact insect morphology. Measuring morphological change in organisms have been used successfully as indicators of environmental and ecological disturbance. Changes that take place in an insect’s morphology may indicate …

Hippocampal Connectivity In Parkinson's Disease, Landis Llewelyn

Honors Theses

Background: This thesis was conducted in order to investigate possible connections between functional connectivity of the hippocampus in individuals who have Parkinson’s disease.

Methods: The MRI images, the clinical data, and the demographic data of 93 individuals with PD and 18 individuals without PD were obtained from the Parkinson's Progression Markers Initiative. Resting-state fMRI data from a group of PD patients was compared to a control group of non-PD patients by using previously published methods with FMRIB Software Library (FSL) as well as Analysis of Functional Neuroimages (AFNI).

Results: Compared to the control (non-PD) group, results bilaterally showed lesser connectivity …

Repurposing Antiplatelet Drugs To Treat Platelet Mediated Metastasis, Brianna Chambers

Honors Theses

By applying cardiovascular drugs, which already have been proven effective and safe, to other diseases we can speed the drug discovery process, specifically to translate them into treatments for platelet-mediated metastasis. Each cardiovascular drug within antiplatelet drugs, targets one of the four following pathways: COX-1, thromboxane, P2Y12, or thrombin. There has been varying levels of success with treating adenocarcinomas like breast and colorectal cancer. Continued success in treatment could be the result of pharmacogenetics and further evaluation of dosage levels. By isolating mutation rates in various adenocarcinomas there is the possibility of a targeted treatment based on the mutated gene.

Incorporating Demographic Structure And Variable Interaction Types Into Community Assembly Models, Akhil Reddy Alasandagutti, Nayan Chawla

Honors Theses

Theoretical studies of ecological food webs have allowed ecologists to remove the constraints of specific location and timescales from their study of ecological communities; food webs are generally complex and thus empirical study is difficult. Further, this theoretical approach allows ecologists to compare ecological processes and outcomes across any possible food web structures. However, these simulated communities are only as useful as the model from which they were constructed. Modifying existing considerations in these models, and generating new ones, are the jobs of theoretical ecologists that seek to achieve the shared goal of a majority of simulations: representation of real …

A Systematic Review Of The Correlation Between Dyslexia And The Axon Guidance Receptor Gene, Robo1, Catherine Day

Honors Theses

This thesis was conducted to investigate further the correlation between the ROBO1 gene and Developmental Dyslexia (DD). DD is when a person is deficient in acquiring literary proficiency even though there is not an intellectual deficit or lack of opportunity to obtain literary skills in an educational environment. Persons with DD are characterized as having difficulties with word recognition, reading fluency, poor spelling, and basic decoding skills. There are several genes that have been evaluated in previous studies as indicators of DD: KIAA0319, DCDC2, DIP2A, and ROBO1. This study is focused on identifying previous published studies that examined specifically the …

Mental Health Stigma Among Pharmacy Professionals And The Need For Continuing Education, Victoria Dale

Honors Theses

Background. The mental health stigma of pharmacists, the most accessible health professional, can have a significant impact on not only how these patients seek treatment, but also their quality of life (Mey et al., 2013). This study intends to explore mental health stigma among pharmacists and also examine the need for continuing education focused on mental health.

Methods. This study was a descriptive cross-sectional study that employed a self-administered online survey. The subjects were pharmacist members of the Mississippi Pharmacists Association (MPhA). Demographic characteristics were collected. The level of mental health stigma among the respondents was examined using the Community …

A Comprehensive Examination Of Pharmacy Technician Requirements And Pharmacists’ Perceptions Of The Role Of Technicians, Courtney Hahs

Honors Theses

Pharmacy technicians play a crucial role in assisting pharmacists and allowing a pharmacy to function properly and provide care to patients. While technicians take on many tasks in a pharmacy, their role has started to evolve and expand. The first purpose of this study was to determine how states differ regarding the following pharmacy technician roles and requirements: whether or not technicians are licensed and/or certified, mandated technician-to-pharmacist ratio, whether or not technicians are allowed to take or give verbal prescriptions, verify filled prescriptions, and provide immunizations. The second purpose was to analyze how pharmacists across the United States viewed …

Chickens In Texas: A Farce In One Act, Lawson Marchetti

Honors Theses

Herein lies a one-act farce written by Lawson David Marchetti, an English major in the Sally McDonnell Barksdale Honors College at the University of Mississippi. His emphasis is in Creative Writing, and his minors are in Theatre Arts and in Music. This farce was written as his senior thesis, for the completion of requirements of the Honors College. The play was conceived in August of 2020, and completed in April of 2021. The play itself is set in modern times, sans pandemic, and is highly whimsical in style. It requires a cast of twelve comedic actors, and several complicated technical …

Dissipation In The 1920s: Disparate Presentations Of Alcohol Consumption In Selected Works Of Hemingway And Fitzgerald, Amanda Wilson

Honors Theses

The objective of this thesis is to explore the ways in which Ernest Hemingway and F. Scott Fitzgerald define the 1920s and, in particular, the American expatriate culture in Europe. Each author describes the culture of the “Lost Generation” in large part through alcohol consumption and dissipation. In their literary works, alcohol is portrayed as glamorous as well as destructive, as both curing and exacerbating post-WWI anomie. Through their chronicling of this era in fiction and nonfiction, each author memorializes their own participation in the culture along with their legendary consumption of alcohol. This study will concentrate upon selected short …

Experimental Evolution And Local Adaptation In Pseudomonas Fluorescens, Alexander England

Honors Theses

Local adaptation occurs in populations when multiple subsets of the same population are exposed to different environmental conditions causing the beneficial evolution of each species in its respective environment (Delph 2018). PURPOSE: Using Pseudomonas fluorescens as a model organism, this project sought to understand how an individual’s relative fitness will be affected after undergoing local adaptation in three different environments. METHODOLOGY: To conduct this experiment, three identical strains of SBW25 and three identical strains of lacZ were grown up in three separate environments. Each environment contained an M9 minimal salt media supplemented with either dextrose, xylose, or a 50/50 mixture …

An Analysis Of The Effects Of Covid-19 On Students At The University Of Mississippi: Family, Careers, Mental Health, Hannah Newbold

Honors Theses

This study analyzes the effects of COVID-19 on students at the University of Mississippi. For students, COVID-19 changed the landscape of education, with classes and jobs going online. Students who graduated in May 2020 entered a poor job market and many ended up going to graduate school instead of finding a job. Access to medical and professional help was limited at the very beginning, with offices not taking patients or moving appointments to virtual only. This would require that each student needing help had to have access to quality internet service, which wasn’t always guaranteed, thus producing additional challenges.

These …

Process Design And Optimization Of A Once-Through Dimethyl Ether Process Using Aveva Process Simulation, Jerrod Scott

Honors Theses

The primary purpose of the project on which I wrote this thesis was to design an optimize a once-through dimethyl ether process utilizing a software called AVEVA Process Simulation. The process was initially modeled and optimized to minimize the EAOC of the distillation column. The result of that effort was an optimized column with six stages with the feed entering the column at stage six. It had a height of 3 m, diameter of 0.44 m, and an EAOC of $65,100. This optimized solution was submitted to a Toller. The Toller provided available equipment to model the plant. From here, …

A Study Of Deep Reinforcement Learning In Autonomous Racing Using Deepracer Car, Mukesh Ghimire

Honors Theses

Reinforcement learning is thought to be a promising branch of machine learning that has the potential to help us develop an Artificial General Intelligence (AGI) machine. Among the machine learning algorithms, primarily, supervised, semi supervised, unsupervised and reinforcement learning, reinforcement learning is different in a sense that it explores the environment without prior knowledge, and determines the optimal action. This study attempts to understand the concept behind reinforcement learning, the mathematics behind it and see it in action by deploying the trained model in Amazon's DeepRacer car. DeepRacer, a 1/18^th scaled autonomous car, is the agent which is trained …

An Analysis Of Teacher Placement And Retention In The Mississippi Excellence In Teaching Program, Abby Johnston

Honors Theses

The Mississippi Excellence in Teaching Program (METP) was created in 2013 by a privately-funded grant from the Hearin Foundation of Jackson, Mississippi. In exchange for a full cost-of-attendance scholarship, undergraduate participants in the program at both the University of Mississippi and Mississippi State University commit to teaching at a public school in Mississippi for five years after graduation. The purpose of this study is to analyze the teacher placement and retention rates of METP in order to draw conclusions on its effectiveness at retaining high-performing high school students to become teachers in the state of Mississippi.

This study was conducted …

Effectiveness Of Visual Representations In Undergraduate Human Anatomy And Physiology I & Ii, Mary Agnes Mestayer

Honors Theses

The objective of this project was to explore intersections between student preferences and student performance on anatomical visual representations in Human Anatomy and Physiology I and II. Visual representations are a critical resource for the formation of relationships between function and structure furthermore; students interpret these representations uniquely based on specific factors (learning objective, prior knowledge, the diagram studied, etc.). Phase I of this project gathered undergraduate responses to ten Likert-style questions on their opinions on diagrams and their use in the A&P classroom. Phase II of this project presented participants with twelve manipulated diagrams sourced from three diagram with …

Examining Construction And Reproduction Of The Educational Opportunity Gap: The Nation’S School Board Members Respond, Hallet Demouy

Honors Theses

This thesis explores opportunity gaps, often related to achievement gaps, in education via the analysis of school board members’ responses regarding challenges that face future education, students, and the public school system. The perceptions of these school board members serve to address the sources, prevalence, and effects of inequities that exist in widening (perpetuating) this gap between students. After discussing and elaborating upon the perceived challenges and barriers located in the institution of education, school board member responses will again be used to present potential ways and opportunities through which the achievement gaps, relating to the success rates and testing …

Pain Management Approaches & Experiences: A Systematic Review Of Racial & Gender Differentials, Ann Hoover

Honors Theses

Health care disparities and the social determinants of health (SDOH) are beginning to integrate into public and political narratives of systemic inequities. Pain management is a wide-reaching domain of health care, with complexities arising from the subjectivity of pain and the implications for clinical care. In this thesis, I conduct a systematic literature review to explore the effects of race and gender on pain assessment, diagnosis, and treatment through a health equity lens. While much of health care disparity research emphasizes the effects on population health outcomes, these findings redirect attention to the tangible impacts of discriminatory encounters and experiences …

Gay Identity In The Gdr: The Homosexuelle Interessengemeinschaft Berlin Between Self-Expression And State Control, Susanna Cassisa

Honors Theses

This thesis examines the Homosexuelle Interessengemeinschaft Berlin (HIB), the

first gay liberation group in the German Democratic Republic (GDR). Specifically, it analyzes the demands and tactics of the HIB alongside London Gay Liberation Front activist Peter Tatchell at the tenth World Festival of Youth and Students (WFYS) in 1973. This study analyzes four primary sources: 1) the HIB’s banner from the WFYS, 2) the leaflet Tatchell distributed at the WFYS, 3) Tatchell’s placard from the WFYS, and 4) a 1978 letter from the HIB to the People’s Chamber arguing for a socialist information center geared toward a homosexual patronage. I …

The Role Of Cannabinoid Receptor 2 In Zebrafish Toxicities Following Developmental Exposure To Thc Or Cbd, Haley Watts

Honors Theses

As the laws concerning the regulation of Cannabis Sativa change across the globe, maternal use of cannabinoid-containing products during pregnancy is a greater concern than ever before. Little research has been conducted on the consequences of maternal use and developmental exposure to ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD. In this study, larval zebrafish (Danio rerio) were used to measure CBD and THC-mediated adverse outcomes including effects on larval length, eye area, and behavior in the cnr^+/+ and cnr2^-/- zebrafish strains where we discovered that cannabinoid exposure results in a decrease in each of these endpoints. Adult …

The Importance Of A Multidisciplinary Approach To Public Health: Addressing Food Insecurity Through A Biological And Sociological Lens, Chloe Grant

Honors Theses

Plants can sense the change of 1 ^oC in their growth environment and thus global climate change has a great impact on plant growth and development. The phenomenon that warm non-stress temperatures promote stem and petiole elongation, as well as leaf hyponastic growth, is collectively known as thermomorphogenesis. While it is known that the basic helix-loop-helix (bHLH) transcription factor PIF4 is highly inducible by temperature elevations and controls thermomorphogenesis in dicots (e.g., Arabidopsis thaliana), the molecular mechanism underlying thermomorphogenetic growth in monocots is not clear. In this study, I identify PIF4 orthologs in several economically important monocotyledonous species and …

Responses To Fine Particulate Matter (Pm2.5) Exposures In Two Wild-Type Zebrafish Strains, Connor Necaise

Honors Theses

Atmospheric fine particulate matter (PM_2.5) exposure poses great health risks across the globe, causing both acute and chronic illnesses in humans. Therefore, a more complete understanding of the mechanisms in which PM_2.5 induces these adverse health effects is urgently needed. Oxidative stress due to PAHs and other common components of PM_2.5 is a proposed mechanism for its adverse health effects. However, little is known about the actual mechanisms of PM_2.5 damage in humans. This study aimed to distinguish behavioral differences in two lines of zebrafish (AB & 5D) as a result of developmental exposure to …

Spectroscopic Analysis Of Potential Astromolecules Via Quantum Chemical Quartic Force Fields, Mason Gardner

Honors Theses

Astrochemistry has been substantially aided by computational techniques, particularly through the use of Quartic Force Field (QFF) analysis. Several methods have proven useful at correlating computed spectroscopic data with experimental observations. The F12-TZ QFF correlated well with experimental data for silicon oxide compounds, particularly those potentially involved in development from rocky bodies to planetary masses [27]. Compared to argon matrix experimental data, the vibrational frequencies for the molecules SiO2, SiO3, Si2O3, and Si2O4 become less accurate as the complexity of the molecules increases but should still be predictive of infrared characteristics of silicon oxides as they form clusters in space …

Analyzing The Effects Of E-Hook Peptides On Kinesin-1, Ashton Ward Murrah, Baylee Hope Howard

Honors Theses

Cancer is the second leading cause of death in the United States. Cancerous growth is a result of oncogenes, or mutated genes that increase the rate of cell division in an uncontrolled manner. Cell division, which consists of mitosis and cytokinesis phases, is dependent upon the active movement of kinesin motor proteins along microtubules to rearrange the cytoskeleton for equitable distribution of genetic material to daughter cells. As kinesins are vital to this process, if we could prevent kinesin from binding to the microtubules, cell division would cease.

The goal of this study is to develop a method to prevent …

Determination Of Metals In Whey And Vegan Protein Supplements Using Inductively Coupled Plasma Mass Spectrometry, Megan Lofaso

Honors Theses

Driven by a demand for health and wellness products worldwide, the dietary supplement industry continues to expand with an economic impact >$100 billion in the USA alone. However, the industry is plagued by a lack of regulation and incidents of contamination, including with toxic heavy metals that can put consumers at potential risk. In this study, eight trace elements (Cd, Pb, Fe, Co, Mn, V, Cu, and Cr), including heavy metals (Cd and Pb), were determined in whey and vegan protein powder by inductively coupled plasma mass spectrometry (ICP-MS) after microwave-assisted digestion using nitric acid and hydrogen peroxide. Samples were …