Digital Commons Network^™

Expression Profiling And Bioinformatic Characterization Of Depalmitoylation-Associated Genes During Sh-Sy5y Neuronal Differentiation, Ayesha Lodhi

Seton Hall University Dissertations and Theses (ETDs)

Palmitoylation is a reversible post-translational modification involving covalent attachment of palmitoyl groups to cysteine residues. Till date, 23 members of this family have been identified in mammals, located in Golgi apparatus and endoplasmic reticulum and nearly 40% of synaptic proteins are estimated undergo palmitoylation. These proteins include vesicle fusion proteins (SNARE), signaling molecules, ion channels and neurotransmitter receptors such as gamma-aminobutyric acidreceptors, kainate receptors and glutamate receptors. While its role in neuronal function has been widely recognized, comparatively little is known about how depalmitoylation-associated enzymes are regulated during neuronal differentiation. The present study aimed to characterize changes in depalmitoylation-associated gene …

Integrative Rna-Seq Analysis Reveals Stress Type-Dependent Lncrna-Centered Co-Expression Networks Across Human Cellular Stress Contexts, Christina Anastasiadi, Aggeliki Kasapi, Ioannis Sentementes, Vasileios Gouzouasis, Margaritis Tsifintaris, Antonis Giannakakis

Computational Medicine Center Faculty Papers

Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular adaptation to environmental and molecular stress, but the extent to which their responses remain reproducible and stress-type-dependent across human stress conditions remains unclear. Here, we performed an integrative transcriptomic meta-analysis of human stress-response datasets from ASTRA and GEO, focusing on normal, non-cancerous, wild-type human cell lines exposed to oxidative stress (H2O2), hypoxia, heat stress, or UV-induced DNA damage. Gene Ontology (GO) enrichment analysis of differentially expressed (DE) protein-coding mRNAs confirmed that the resulting stress-stratified comparison captured biologically coherent transcriptional programmes to oxidative stress signaling, hypoxic and metabolic adaptation, heat-induced …

Host-Pathogen Dynamics Underpinning Staphylococcus Aureus Growth During Intracellular Osteoclast Infection, Luke D. O'Connor

WUSM Theses and Dissertations – All Programs

Bone infection is most commonly caused by the gram-positive bacterium Staphylococcus aureus. It has myriad ways in which it can circumvent or subvert killing by the host or antibiotics. Intracellular infection is one such niche that is protective from immune and antibiotic attack. In 2019, Krauss and colleagues discovered that infected osteoclasts (OCs) allow S. aureus to replicate intracellularly. There they found that the ability of S. aureus to grow inside the cell was tied to OC differentiation. The magnitude of overnight bacterial expansion positively correlated with OC maturity and duration cultured with the osteoclastogenic factor RANK ligand (RANKL). Bacterial …

“Something Else To Focus On”: Perinatal Havening And Stress Coping In Pregnant Black Women, Brittany L. Ferrell Young

WUSM Theses and Dissertations – All Programs

Black women in the United States experience maternal mortality at more than three times the rate of white women, a disparity driven by chronic stress rooted in structural racism rather than individual behavior or biology. Accessible, culturally responsive tools for managing stress during pregnancy remain scarce. This mixed-methods pilot feasibility study examined Perinatal Havening, a self-administered psychosensory technique, as a stress management intervention for pregnant Black women. Guided by Lazarus and Folkman's Transactional Theory of Stress and Coping, the study addressed three questions: how Black women experience acute and chronic stress during pregnancy, the acceptability and preliminary influence of Perinatal …

Artificial Intelligence And The Rediscovery Of The Human: An Islamic Reflection On Magnifica Humanitas, Mazhar Ali Bari, Biliana Popova

The Journal of Social Encounters

No abstract provided.

Patterns Of Age At First Birth And Child Spacing Behaviour Among Women In Ilorin Metropolis, Nigeria, Ismaila O. Orire

The Journal of Social Encounters

Age at first birth influences the length of a woman's reproductive years and affects fertility behavior including choices of child spacing which have profound influence on future population structure and dynamics. This study examines women’s demographic and social characteristics; identified their ages at first birth and relationship with status of marriage; their child spacing behavior; contraceptive usage; and duration of breastfeeding after child birth. Primary source of data was questionnaire administered to women of reproductive age representing three age cohorts whose ages range between 35-44, 25-34 and 15-24 years respectively. Systematic random sampling technique was adopted to ensure representativeness and …

Pax Christi International’S Representation Within International Governmental Organisations, Fr. Paul Lansu, Giulia Bordin

The Journal of Social Encounters

Pax Christi International (PCI) has used its consultative status at the United Nations since 1979 to connect grassroots peacebuilding with international policymaking. Initially focused on disarmament and human rights, PCI contributed to key international treaties and advocated against human rights violations worldwide. Over time, its advocacy expanded to include active nonviolence, ecological justice, sustainable development, and the accompaniment of local peacebuilders. By strengthening collaboration across its global network and enabling partners from conflict-affected regions to engage directly with international institutions, PCI continues to promote human dignity, international law, and a just and lasting peace through inclusive multilateral advocacy.

“The Rubber Lung” - An Original Instrument Design, San Gonzalez

2026 Symposium

This project presents an experimental sensor-based instrument designed to produce unconventional sound textures for horror media. The device uses a flex sensor on a balloon that is then connected to an Arduino, which responds to bending and movement, sending data to a Max/MSP patch where the input controls sound processing such as filters and frequency. The physical motion of flexing the sensor on the balloon mimics the expansion and contraction of lungs, creating a breathing like interaction between performer and instrument. This design allows subtle gestures to alter the sound in real time. By using a bodily, breathing motion into …

Eat, Rot, Repeat: Consumption And Decomposition In Poe’S Pym, Darcy Zobel '26

Furman Humanities Review

No abstract provided.

To Read An Anti-Oedipa? Visions Of Postmodern Sexuality In The Crying Of Lot 49 And The Potential For Sexual Liberation, Eric Neumann '26

Furman Humanities Review

No abstract provided.

Table Of Contents, And Introductory Information, Gretchen Braun Editor

Furman Humanities Review

No abstract provided.

Furman Humanities Review. Volume 37, July 2026, Gretchen Braun Editor

Furman Humanities Review

No abstract provided.

Determinants Of Ai Adoption In Banking: Evidence From Tunisia, Rahma Khattab, Sami Bacha

Arab Economic and Business Journal

This study investigates the factors influencing customers’ intentions to adopt Artificial Intelligence (AI) banking services in Tunisa. Building on an integrated framework combining the Technology Acceptance Model, Unified Theory of Acceptance and Use of Technology, Theory of Planned Behavior, Perceived Risk Theory, and Diffusion of Innovation Theory, the study investigates how perceived usefulness, perceived ease of use (, awareness, knowledge, attitude, subjective norms, trust, and perceived risk influence AI adoption intentions. Using survey data from 400 Tunisian retail banking customers and applying regression analysis, the findings show that perceived usefulness, perceived ease of use, subjective norms, and trust positively and …

Imsa Summer Symposium 2026, Student Inquiry And Research (Sir)

Summer Symposium

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program. For the first time, we are also excited to welcome IMSA Research, Inquiry Skills, and Experimentation (RISE) students to present at the Summer Symposium.

Cover Design

Luke Berryman

Ppt-1 Regulates Lipid Droplet Homeostasis And Promotes Oxidative-Stress Resilience In C. Elegans., Chukwuadinula Deborah Ashiedu

Master’s Theses and Projects

No abstract provided.

Profiling Arbutin As A Potent Cholinesterase And Gsk-3Β Inhibitor And Evaluating Its Cytotoxicity In Sh-Sy5y Cells For Alzheimer’S Disease Therapy, Shirin Tarbiat, Tuğba Bal, Deni̇z Gülmez

Turkish Journal of Biology

Background/aim: Alzheimer’s disease (AD) is a neurodegenerative disorder linked to cognitive decline and memory loss, marked by hyperphosphorylated tau tangles and decreased acetylcholine levels, which are affected by acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activity. Glycogen synthase kinase-3 beta (GSK-3β) also plays a role in AD through abnormal activation. In this study, the potential of β-arbutin to inhibit cholinesterases and GSK-3β was investigated, utilizing in vitro assays, cytotoxicity analysis, and molecular docking simulations to explore its therapeutic implications.

Materials and methods: Ellman’s technique was used to test the inhibitory effects of arbutin on cholinesterase enzymes. An ATP-Glo luminescent assay kit was …

Probiotic Intervention In Colorectal Cancer: The Cytotoxic And Apoptotic Potential Of Lactobacillus Cell-Free Supernatants, Bahar Yilmaz, Berna Erdal

Turkish Journal of Biology

Background/aim: Failures in the treatment of colorectal cancer (CRC) have increased scientific interest in the potential of the bioactive compounds contained in cell-free supernatants (CFSs) obtained from probiotic bacteria for cancer treatment. The aim in this study was to investigate the effects of CFSs obtained from Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) and Lactobacillus paracasei subsp. paracasei (L. paracasei) on colorectal cancer cell lines (HT-29 and Caco-2) and a healthy colon epithelial cell line (CCD841 CoN).

Materials and methods: Cytotoxic effects on the cell lines were determined by MTT assay. In line with the IC50 values obtained, morphological changes were …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Antiatopic Dermatitis Activity Of Lissachatina Fulica Mucin: Network Pharmacology Analysis And Experimental Validation, Atin Supiyani, Wasmen Manalu, Lina Noviyanti Sutardi, Mawar Subangkit, Andriyanto Andriyanto

Turkish Journal of Biology

Background/aim: Lissachatina fulica mucin (LFM) has been used as a nutraceutical, therapeutic agent, and cosmetic ingredient. The bioactivity of mucin depends on bioactive compounds whose composition is strongly influenced by the snail’s diet. This study investigated the bioactive compounds in L. fulica mucin as potential therapeutic agents for atopic dermatitis (AD).

Materials and methods: LFM was collected from snails fed long beans and melon rinds for 4 weeks, freeze-dried, and analyzed using liquid chromatography–mass spectrometry followed by network pharmacology (NP) analysis to identify its bioactive compounds. A total of 60 BALB/c mice were sensitized on the dorsal skin with 1% …

The N-Terminal, Wd40, And C-Terminal Domains Of Wdr-31 Control Ciliary Localization And Cooperate With Elmod/Rp2 Gaps To Maintain Membrane Compartmentalization, Sebi̇ha Çevi̇k, Fatma Güzel

Turkish Journal of Biology

Background/aim: WD40 repeats are found in many ciliary proteins. Although the WD40 repeat-containing WD repeat-containing protein 31 (WDR-31) is known to regulate ciliary protein trafficking and morphology, the specific contributions of its N-terminal, WD40, and C-terminal domains to protein localization and ciliary gate integrity remain unclear. Aim of this study is to dissect the functional roles of WDR-31 domains by investigating their contributions to ciliary localization, ciliary protein trafficking, and gate integrity.

Materials and methods: Using CRISPR/Cas9 technology, we generated Caenorhabditis elegans strains with in-frame deletions that removed the N-terminus (WDR-31(ΔN)), WD40 (WDR-31(ΔWD)), and C-terminus (WDR-31(ΔC)). We next examined the …

Discovery And Functional Characterization Of Novel Programmed Death-Ligand 1 Monoclonal Antibodies, Nurşah Ersezen, Mai̇de Şeker, Arzu Aysan, Durmuş Akdoğan, Mehmet Ender Avci, Asli Kurden Pekmezci̇, Si̇bel Kalyoncu Uzunlar, Mehmet İnan, Tamer Yağci

Turkish Journal of Biology

Background/aim: Targeted therapies with monoclonal antibodies provide cancer patients with better prognosis and diseasefree survival. The blockade of immune checkpoints, including programmed cell death protein-1 (PD-1) and its ligand PD-L1, with monoclonal antibodies may boost immune responses against tumors and is regarded as an effective strategy in cancer immunotherapy. We describe the generation of anti-PD-L1 monoclonal antibodies with high affinity and specificity, and we assess their potential for therapeutic use in cancer.

Materials and methods: Hybridomas were selected for PD-L1 specificity and cross-reactivity with other immune checkpoint proteins and PD-L1 orthologs using indirect ELISA. Immunofluorescence and Western blotting assays were …

Church Tape Collection, Approximately 1969-2008, Ministers

Center for Restoration Studies Archives, Manuscripts and Personal Papers Finding Aids

No abstract provided.

Imsa Summer Symposium 2026, Student Inquiry And Research(Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program. For the first time, we are also excited to welcome IMSA Research, Inquiry Skills, and Experimentation (RISE) students to present at the Summer Symposium.

What Do We Do At The End Of A World?: Cultivating Emergent Leadership In A Time Of Collapse, Brent Godfrey

Journal of Legal Education

No abstract provided.

Genetic Diversity And Rhizome Flesh Color Variation Among Indonesian Turmeric (Curcuma Longa L.) Accession Revealed By Ssr Markers, Suseno Amien, Marisa Anggraeni, Agung Karuniawan, Noladhi Wicaksana

Jurnal Kultivasi

Turmeric (Curcuma longa L.) is a rhizomatous plant widely cultivated in Indonesia. Although recent studies have demonstrated that simple sequence repeat (SSR) markers are highly effective for assessing genetic diversity in Curcuma longa germplasm, most investigations have focused either on molecular diversity or breeding-oriented germplasm characterization traits of agronomic without integrating phenotypic commercial importance, particularly rhizome flesh color. The study was conducted from February to May 2026. This study aimed to evaluate the genetic diversity, phylogenetic relationships, and rhizome flesh color variation among Indonesian turmeric accessions collected by Plant Breeding Laboratory at the Faculty of Agriculture, Universitas Padjadjaran, and was …

For Weight Loss: Why Do Glp-1 Agonists Work, And How Can We Make Them Work Better?, Charlise Giang, Jieyi Meng, Mahmoud Ali Mohammad, Zhenqi Liu, Xinle Wu, Yi Zhu

Children’s Nutrition Research Center Staff Publications

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have revolutionized the management of not only type 2 diabetes but also obesity. However, even with rapid therapeutic advances in GLP-1RAs, questions regarding the fundamental principles of GLP-1-mediated weight loss and the enhanced efficacy of next-generation therapies remain. In this comprehensive review article, we first examine the milestones of GLP-1, from its initial discovery and biological characterization to its successful translation into clinical therapy. Furthermore, this review highlights the latest clinical trial data, specifically HbA1c reduction, weight-loss efficacy, and safety profiles, while exploring current pipelines of major pharmaceutical companies. Additionally, we delineate the mechanistic …

Is Hanpp A Stressor Of Bird Species Richness?, Kaeli Mueller, Gustavo Ovando-Montejo, Christopher Lant

Environment and Society Student Research

One of the leading drivers of biodiversity loss is land use change due to the ever-increasing demand for food, livestock feed, biofiber, and biofuel. The concept of human appropriation of net primary production (HANPP) was developed to measure the impact that humans have on the environment by accounting for biomass removed from the environment in the form of crops, timber, and grazing. The species–energy hypothesis is an established ecological hypothesis postulating that greater species diversity is correlated with higher levels of energy from plant productivity; this can be measured as net primary production minus harvested HANPP or NPP_ecological. …

Enhancing Algae Biofilm Quantity And Value Through Controlled Light Intensity For Treatment Of Municipal Anaerobic Digestor Effluent, Joshua D. Wintch, Ronald C. Sims

Biological Engineering Student Research

Rotating algae biofilm reactors (RABRs) have been shown to remove nutrients from wastewater and to cultivate algae for bioproducts. Another key variable in RABR technology for cultivating microalgae biomass is light intensity. The goal of this study was to address a gap in the design and operation of algae biofilm reactors by analyzing the effects of light intensity on biomass quality and quantity, chemical precipitation of phosphorus, and phosphorus uptake into biomass. This study utilized a triplicate laboratory-scale experiment with PAR intensities from 10 to 2000 µmol m⁻²·s⁻¹. Municipal wastewater anaerobic digester effluent (ADE) was utilized …

Fall Risk In Community-Dwelling Adults: A Comparison Of English And Spanish-Speaking Individuals, Jesus D. Gomez

Dissertations, 2020-current

Falls are a leading cause of injury-related mortality among middle-aged and older adults. Although vestibular dysfunction, hearing loss, behavioral factors, and social determinants of health have been associated with increased fall risk, few studies have examined these relationships. Furthermore, limited research in audiology and vestibular science has investigated fall-risk vulnerability among Spanish-speaking individuals.

This study aimed to: (1) estimate the prevalence of fall risk among community-dwelling adults and compare prevalence between English-speaking and Spanish-speaking participants; (2) assess the prevalence of previously undiagnosed benign paroxysmal positional vertigo (BPPV) and compare prevalence between language groups; and (3) develop predictive models of fall …

Imsa Summer Symposium 2026, Student Inquiry And Reserach Reserach (Sir)

IMSAloquium Event Booklets

For nearly four decades, IMSA has worked to advance the human condition through educational innovation. The Summer Symposium is our annual showcase for the research projects that were conducted in IMSA’s experiential learning programs between May and August. These programs include Student Inquiry and Research (SIR), IN2 Business Internships, and the Student Research and Experiential Learning Opportunity (SRELO) program. For the first time, we are also excited to welcome IMSA Research, Inquiry Skills, and Experimentation (RISE) students to present at the Summer Symposium.

Cover Design

Luke Berryman