Digital Commons Network^™

Beyond Satisfaction: Predictors And Correlates Of Marital Health, Erin C. Smalley

Doctor of Education (Ed.D)

This quantitative, nonexperimental, cross-sectional study evaluated factors associated with and predictive of marital health. Marital health was identified as a more holistic evaluator of marital connection and commitment, moving beyond individual satisfaction. The original sample was taken from the archived Marriage Health in America survey data. The sample included 3,808 United States adults. Participants completed a marital satisfaction index and a marital health measure, while simultaneously ranking 32 identified factors of marital health. The results found that love for each other was the strongest predictor of marital health, followed by communication through listening, respect, trust, and sexual intimacy. These findings …

The Dean's Edit - October 2026, Faculty Of Arts And Sciences

Faculty of Arts and Sciences Archives

• Beyond Academics, With the Dean
• Admissions Are Open, and We're on the Road
• Students Launch the AKU Consulting Group
• FAS Research on the Move
• Karibu Café Is Back
• Learning Biodiversity, Out in the Field
• Honouring Our High Achievers
• Faculty Recruitment and Onboarding in Full Swing

Arcadia Magazine

Alumni Magazine

No abstract provided.

Streamlining Diagnosis Of Bardet-Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria., Jeremy J. Pomeroy, Jesse Richards, Brooke Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma Mcgibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales

Manuscripts, Articles, Book Chapters and Other Papers

Considerable advances have been made in our understanding of Bardet-Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence-based, and consensus-driven process, a multidisciplinary group of international experts and patient-led organizations developed an updated diagnostic algorithm. This algorithm provides practical, updated guidance for clinicians, including a pathway for accurately incorporating genetic findings into the diagnostic process. We recommend that a clinical diagnosis requires either 4 major criteria or 3 major and 2 minor criteria. Revised major criteria are retinal dystrophy, obesity (or overweight in individuals <  2 years old), congenital anomalies of the kidney and urinary tract or chronic kidney disease, hypogonadism/genital anomalies, neurodevelopmental/neurocognitive manifestations, and postaxial polydactyly. The diagnosis can also be established with a positive genetic testing result in patients exhibiting ≥ 1 major criterion, provided that genetic findings should be interpreted in the context of the patient's clinical presentation, age, family history, and overlap with related ciliopathies. These consensus criteria offer a simple algorithm incorporating updated definitions for major and minor criteria and genetic testing to support a timely and accurate diagnosis of patients with BBS, inform genetic counseling, and potentially facilitate earlier access to treatment. Trial Registration: CRIBBS Registry; ClinicalTrials.gov: NCT02329210.

Clinical Function Assignment Of Nat2 Alleles By The Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel., Bailey M. Tibben, David W. Hein, Michelle Whirl-Carrillo, Andrea Gaedigk, Michael T. Eadon, Rodney F. Minchin, Sotiria Boukouvala, Adalberto Rezende Santos, Roseann S. Donnelly, José A G Agúndez, Kelly E. Caudle

Manuscripts, Articles, Book Chapters and Other Papers

NAT2 encodes arylamine N-acetyltransferase 2, a key enzyme in the phase II metabolism of arylamines and arylhydrazines. NAT2 is highly polymorphic, resulting in variable distributions of rapid and poor metabolizers across global populations. Here, we detail the process undertaken by the Clinical Pharmacogenetics Implementation Consortium (CPIC) NAT2 Pharmacogene Curation Expert Panel (PCEP) to assign clinical function to NAT2 star (*) alleles using CPIC's standard terminology. Given the observed impact of NAT2 genetic variability on drug response, CPIC convened the NAT2-PCEP to standardize clinical allele function assignments. The NAT2-PCEP is comprised of multidisciplinary and international members, including researchers, clinicians, and implementers …

Ewsr1-Fli1 Expression Combined With Monoallelic Ewsr1 Depletion Is Associated With Mitotic Spindle Damage And Nocodazole Sensitivity., Evan T. Schulz, Alejandro Parrales, Tomoo Iwakuma, Mizuki Azuma

Manuscripts, Articles, Book Chapters and Other Papers

Microtubule-destabilizing agents (MDAs) and microtubule-stabilizing agents (MSAs) are commonly used chemotherapeutic agents due to their ability to induce cell death by compromising the dynamics of spindles during mitosis. Ewing sarcoma, the second most common pediatric bone cancer, is known to selectively respond to MDAs as a first-line treatment, but not to MSAs. Ewing sarcoma cells carry an aberrant EWSR1-FLI1 fusion gene and only one wild-type EWSR1 allele. To investigate the origin of this MDA sensitivity, we used an isogenic cell line carrying a (AID-EWSR1/wt;EWSR1-FLI1-mCherry/wt) genotype that enables conditional induction of EWSR1-FLI1 expression (Tet-On system) and EWSR1 knockdown derived from one …

An Eco-Inspired Emulsion Membrane Harnessed With Waste Vegetable Oil For Effective Separation Of Ibuprofen: Insights Into Stability, Performance, And Kinetics, Huma Warsi Khan, A. Vijaya Bhaskar Reddy, Parvez Alam Khan, Samsur Akm Rahman, Muhammad Moniruzzaman

Publications and Research

Emulsion liquid membranes (ELMs) have emerged as excellent alternatives for the separation and recovery of biologically active drugs (BADs) from industrial waste at trace concentrations. Conventional ELMs generally utilize toxic petroleum-based solvents (PBS) that pose environmental and health risks. Although virgin vegetable oils have been appeared as sustainable alternatives to PBS, their widespread application is limited by economic constraints, resource sustainability, and competition with the food supply. In contrast, waste vegetable oil (WVO) represents an abundant, low-cost, and eco-friendly alternative, yet its potential as a green diluent for ELMs remains largely unexplored. To address this challenge, present study investigated the …

Legalist Verses Realist Accounts Of United States V. Skrmetti, Neil S. Siegel

Faculty Scholarship

Although the Supreme Court is increasingly adopting an understanding of sex discrimination that is biologically focused and/or formalistic, this Article argues that the Court does not consistently apply that conception when doing so benefits transgender Americans. The Court’s conclusion in United States v. Skrmetti that no facial sex classification exists in Tennessee’s law banning gender-affirming care for transgender—but not cisgender—minors is irreconcilable with its conclusion five years earlier in Bostock v. Clayton County that Title VII’s prohibition on sex discrimination prohibits employers from firing employees just because they are transgender. Perhaps tellingly, only Justice Gorsuch, Bostock’s author, and Chief Justice …

Exploring The Risk Factors Associated With Poor Maternal Health And Mortality In Bangladesh, Sheikh Sarahzin Ahmed

Graduate Research - Health Sciences

Background

Poor maternal health and mortality remain a major public health concern in Bangladesh. Being a lower-middle-income country, Bangladesh is struggling to decrease maternal mortality ratio (MMR). 115 women die per 100,000 live births in 2023 due to pregnancy-related causes in Bangladesh. (World Bank Group, 2025). It is found that 73% of maternal deaths occur during postnatal period and 56% die within 24 hours of delivery, indicating the importance of early postnatal care (PNC) to reduce maternal mortality. (Bangladesh National Strategy for Maternal Health (2019–2030). Besides this, food insecurity, maternal nutrition, child marriage, patriarchal influence, decision making role, limited access …

From Homes To Classrooms: Cultural Wisdom As A Guide For Stem Lesson Planning, Miriam Ortiz, Uma Ganesan, Angela Chapman, William Medina-Jerez, Ruby Lynch Arroyo, Mourat Tchoshanov

Teaching and Learning Faculty Publications

This article describes innovative elementary science instructional approaches based on cultural wisdom developed by preservice teachers enrolled in a teacher preparation program at a university in the U.S.-Mexico border region. As a part of a larger study, three Latina preservice elementary teachers were a part of a teacher residency in conducting community interviews and reflection activities to uncover cultural backgrounds that could inform culturally relevant STEM lesson planning, centering on family and home knowledge. This project began with family interviews during winter break and culminated in lesson planning and implementation during their science methods course in the spring semester. The …

The Case For And Against Keeping Complete Denture Fabrication In The Uk Undergraduate Curriculum, James Puryer

Peninsula Dental School

As complete edentulism becomes less common, should complete denture fabrication remain at the heart of undergraduate dental training?

Operationalising Equity In Ecosystem-Based Fisheries Management, Riley Bibaud, Tom Mullier, Matthew Ashley, Holly Niner, Lauren Stewart, Siân Rees

School of Biological and Marine Sciences

Equity is increasingly recognised as a critical dimension of sustainable ocean governance, yet operational frameworks for incorporating equity considerations into marine governance remain limited. Fisheries management practices have traditionally concentrated on stock sustainability and commercial extraction, often without fully addressing the broader ecosystem dynamics that underpin fish populations throughout key life stages. This study explores how Ecosystem-Based Fisheries Management (EBFM) can support more equitable outcomes by applying a beneficiary-centric natural capital framework to the Celtic Sea and Western Channel Pelagic Fisheries Management Plan. A typology of beneficiaries was developed to assess the distribution of ecosystem service benefits, followed by a …

Supporting Socialization & Expression In Ltc: A Scoping Review Of Language Barriers & Older Adults, Christina Oleynikov, Amanda Mcintyre

International Nursing Research Congress (INRC)

Communication is central to socialization and the expression of cultural identity [7]. In multilingual societies such as Canada, language barriers can hinder full integration, affecting social participation and overall quality of life [6,7,9]. The proposed study focuses on language barriers faced by minority older adults in long-term care settings. Non-English speaking residents who face barriers in communication and lack the adequate support necessary to overcome them, become vulnerable to impaired meaningful interactions and social isolation [3,11]. This study plans to gather and review existing scientific literature on how these barriers affect older adults and impact their socialization needs. A scoping …

Recanalisation Quality, Not First-Pass Effect, Drives Outcomes In Paediatric Mechanical Thrombectomy: A Multicentre Prospective Study, Adam A. Dmytriw, Iman Kiani, Kartik Bhatia, Todd Abruzzo, Lisa Pabst, Stuart Fraser, Melissa Chung, Warren Lo, Ahmed Othmann, Ameer E. Hassan

School of Medicine Publications

Introduction: In adult endovascular thrombectomy (EVT), first-pass success is associated with better outcomes, but whether this "first-pass effect" also holds true in childhood stroke remains unknown. We investigated the association of thrombectomy pass counts with 90-day outcomes after paediatric EVT.

Patients and methods: We analysed prospectively collected data from the international Save ChildS Pro registry (ages 0-17 years). All EVT-treated patients were included irrespective of the reperfusion grade achieved. Successful reperfusion was defined as expanded thrombolysis in cerebral infarction (eTICI) ≥ 2b and complete/near-complete reperfusion as eTICI 2c-3. The primary outcome was ordinal 90-day mRS in a proportional odds model. …

A Prospective Natural History Study Protocol For Clinical Trial Readiness In Synaptic Disorders, Joeylynn Coyne, Ian Mcsalley, Michael C Kaufman, Bintou Bane, Torrey Chisari, Jonathan Toib, Carlyn Glatts, Sarah Tefft, Julie M Orlando, Viveknarayanan Padmanabhan, Alexander K Gonzalez, Alicia Harrison, Charlene Woo, Stephanie A Zbikowski, Rency Dhaduk, Johanna Mercurio, Macie Mccarthy, Jan H Magielski, Zachary Grinspan, Megan Abbott, Juliet Knowles, Hsiao-Tuan Chao, Katherine Xiong, Elizabeth Berry-Kravis, Sepideh Tabarestani, J Michael Graglia, Kathryn Helde, Virginie Mcnamar, Charlene Son Rigby, James Goss, Scott Demarest, Andrea Miele, Benjamin Prosser, Michael J Boland, Samuel R Pierce, Ingo Helbig

Faculty, Staff and Students Publications

Objective: STXBP1-related disorder (STXBP1-RD) and SYNGAP1-related disorder (SYNGAP1-RD) are two common genetic synaptopathies that are associated with epilepsy, developmental delay, intellectual developmental disorder, and behavioral problems. Both STXBP1-RD and SYNGAP1-RD are potential targets for disease-modifying therapies, but there is limited information in the literature describing the natural history of either disorder, which impedes outcome selection for future clinical trials. The objective of this study is to develop a framework to better define and outline the clinical spectrum and longitudinal trajectories of STXBP1-RD and SYNGAP1-RD natural history, including development, behavior, seizure histories, and electrophysiology.

Methods: Here, we describe a protocol, regulatory …

Chronic Pain And Mobile Health: Are The Apps That Occupational Therapists Recommend Of High Quality?, Jessica Smith, Thuy Tran, Jacqui Hunt, Katrina Liddiard

Research outputs 2022 to 2026

Introduction: Chronic pain is a biopsychosocial experience that can impact peoples' ability to participate in everyday occupations. Mobile health applications, or apps, have the potential to make chronic pain services more effective and accessible. However, the quality of many health apps is not known, which creates a critical challenge for occupational therapists who aim to deliver evidence-informed intervention. This study rated the quality of apps available for Australian occupational therapists to use with clients who have chronic pain.

Consumer and Community Involvement: No consumer and community involvement.

Methods: This study used a cross-sectional descriptive design to (1) identify chronic pain-relevant …

Structural Attributes Of Dominant Seagrass Species Modulate Invertebrate Assemblages Within The Shark Bay World Heritage Area, Inês Leal, Daniel Gorman, Lauren Mukheibir, Keisha Desmond, Simone Strydom

Research outputs 2022 to 2026

The structural complexity of seagrass meadows plays a central role in shaping the diversity and composition of associated invertebrate assemblages. In the Shark Bay World Heritage Area of Western Australia, the dominant species Amphibolis antarctica and Posidonia australis differ markedly in their above- and below-ground morphology, yet the invertebrate assemblages they support remain poorly characterised. This study provides the first contemporary assessment of these habitat–invertebrate relationships, a timely contribution given the region’s increasing exposure to frequent and extreme climatic events. We identified 13,124 invertebrates from 7 phyla, 16 classes and 55 orders/families and highlight marked differences between epifaunal assemblage structure …

A Geothermal Amoeba Sets A New Upper Temperature Limit For Eukaryotes, H. Beryl Rappaport, Natalie A. Petek-Seoane, Tomas Tyml, Jessica K. Niblo, Felix Mikus, Naomi E. Gilbert, Kurt Labutti, Godwin Ani, Ethan Macvicar, Rachel M. Shepherd, Kenneth M. Stedman, Multiple Additional Authors

Biology Faculty Publications and Presentations

The study of temperature limits has transformed our understanding of life’s boundaries but has focused on bacteria and archaea. For decades after their discovery, no eukaryote was shown to replicate above 60◦C. We isolated a geothermal amoeba, Incendiamoeba cascadensis, that divides at 63◦C and is motile up to 64◦C. We identified an enrichment of genes related to proteostasis and environmental sensing relative to mesophilic amoebae. Comparative RNA sequencing of I. cascadensis revealed upregulation of pathways related to proteostasis, DNA repair, and membrane trafficking at high temperatures. Predicted proteins of I. cascadensis have distinct biophysical properties, including enrichment of positively charged …

Expanding The Global Diversity Of From Deep-Sea Hydrothermal Vents, Anna-Louise Reysenbach, Emily St John, Ryan Catchpole

Biology Faculty Publications and Presentations

The archaeal symbiotic have been isolated with their hosts from a shallow hot marine vent off Iceland and from terrestrial hot springs in Yellowstone National Park and Japan. They have highly reduced genomes and rely on their archaeal hosts for most of their metabolic needs. Here, to provide further insights into the ecology and evolution of this order, we greatly expand their phylogenomic distribution using metagenome-assembled genomes from deep-sea hydrothermal vents in the Atlantic, Pacific and Indian Oceans, and the Gulf of California. We show that at least 11 novel genus-level lineages occur at deep-sea vents. We conservatively propose two …

Spatial Bias In Quality Of Estimated Delivery Date Records In The Electronic Health Record, Abigail Lewis, Randi Foraker, Min Lian, Min Zhao, Inez Oh, Aditi Gupta, Antonina Frolova, Philip R O Payne

2020-Current year OA Pubs

OBJECTIVES: This study evaluates the quality of estimated delivery dates (EDD) captured in electronic health record (EHR) systems, focusing on identifying and quantifying bias in these estimates for patients seeking prenatal care.

MATERIALS AND METHODS: We measured spatial and racial biases in the completeness and concordance of EDDs recorded in the EHR for patients seeking prenatal care. Element presence and agreement were compared across the catchment area to identify spatial patterns of bias in EDD records.

RESULTS: We obtained 38 477 unique pregnancy episodes in the EHR representing 33 081 unique patients between 2018 and 2022. Clear spatial and racial …

A Deep-Learning Based Biomarker Of Systemic Cellular Senescence Burden To Predict Mortality And Health Outcomes, Shangshu Zhao, Chia-Ling Kuo, Eric J Lenze, Julie L Wetherell, Laura Haynes, Perla El-Ahmad, Richard Fortinsky, George Kuchel, Trevor Harris, Breno S Diniz

2020-Current year OA Pubs

The accumulation of senescent cells is a recognized hallmark of biological aging and is associated with the onset of multiple chronic medical conditions. Senescent cells exhibit a distinct secretory profile, known as the senescence-associated secretory phenotype (SASP), which can propagate cellular senescence to neighboring and distant tissues. Measuring SASP factors in blood serves as a practical proxy for cellular senescence burden and may help track disease states and intervention outcomes. We developed and validated a composite SASP Score by integrating large-scale population proteomics data with a semi-supervised deep learning framework. The analytical workflow included: (1) selection of biologically curated SASP …

Unveiling Functional-Metabolic Synergy In The Healthy Brain: Multivariate Integration Of Dynamic [18f]Fdg-Pet And Resting-State Fmri, Claudia Tarricone, Giulia Vallini, Giorgia Baron, Massimiliano Facca, Erica Silvestri, Tommaso Volpi, Andrei G Vlassenko, Manu S Goyal, Alessandra Bertoldo

2020-Current year OA Pubs

Despite accounting for only 2% of body weight, the human brain requires significant amounts of glucose, even at rest, underscoring the importance of functional-metabolic relationships. Previous studies revealed moderate associations between resting-state fMRI functional connectivity (FC) and local metabolism via [

Quaker Campus, October 1, 2026 (Vol. 25, Issue 3), Whittier College

Quaker Campus

No abstract provided.

What Controls The Spatial Variation In Thermal Sensitivity In A Cascades River Basin During An Extreme Heat Year?, Savannah Milburn, Michael Krochta, Heejun Chang

Geography Faculty Publications and Presentations

Increasing stream temperatures resulting from climate change and consequent detrimental impacts on temperature‐dependent aquatic species have signalled the need to better understand how different streams respond to changes in air temperature. This research generates a new assessment of thermal sensitivity in the Clackamas River Basin, Oregon, USA by analysing how underlying geology, climate, hydrology and land cover explain spatial variation in stream thermal sensitivity. Multiple linear regression analysis using spatially explicit landscape predictors across 72 sites identified upstream High Cascades geology, elevation, baseflow index, total upstream area and upstream shrubland area as the most significant and stable predictors determining thermal …

Ambulatory Blood Pressure Thresholds And Left Ventricular Hypertrophy In Children Aged 6-12 Years: A Pediatric Nephrology Research Consortium Study., Afsana Jahan, Matthew Schuchman, Mahie Abdullah, Meghan Mclaughlin, Emilia Maria Cadiz, Eshanika Manchanda, Aftab Chishti, Maggie Murphy, Sarah Twichell, Alexandra Mazo, Dmitry Samsonov, Aesha Maniar, Hannah Kim, Francis Lomanta, Ashok Chakravarthy Patibandla, Rachel Frank, Tarak Srivastava, Ikuyo Yamaguchi, Christine Sethna

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To evaluate the diagnostic performance of ambulatory blood pressure monitoring (ABPM) thresholds for predicting left ventricular hypertrophy (LVH) in children aged 6-12 years.

STUDY DESIGN: A retrospective, multicenter study was conducted across 11 Pediatric Nephrology Research Consortium sites and included children aged 6-12 years who underwent ABPM and 2-dimensional echocardiography for diagnostic assessment of elevated BP. The diagnostic accuracy of fixed ABPM thresholds and the current 95th percentile for sex and height were assessed using area under the receiver operating characteristic, sensitivity, specificity, and Youden index. Multivariable logistic regression models, adjusted for age, sex, and body mass index z-score, …

Characterization Of The Genotypic And Phenotypic Spectrum Of Tcf7l2-Related Neurodevelopmental Disorder (Trnd)., Sally Nijim, Mimi Kim, Melissa Denish, Michael V Gonzalez, Joseph Zinski, Claudine Rieubland, Dominique Braun, Elsebet Ostergaard, Amelle Shillington, Laurence Faivre, Julien Maraval, Aurore Garde, Christophe Philippe, Fréderic Tran-Mau-Them, Amy Crunk, Uci Gregor Site, Megan Hawley, Bert Callewaert, Maria Iascone, Anna Cereda, Cecilia Daolio, Tova Hershkovitz, Jean-Marc Good, Katharina Steindl, Tanja Frey, Anita Rauch, Alexandra Afenjar, Cyril Mignot, Jean-Madeleine De Sainte Agathe, Nicolette Den Hollander, Yvonne Hilhorst-Hofstee, Saskia Koene, Gijs Santen, Emilia K. Bijlsma, Sara Berger, Lakshmi Mehta, Radka Stoeva, Clara Houdayer, Paul Gueguen, Helene Faust, Sabine Specht, Annick Klabunde-Cherwon, Melik Malek Khelifa, Anke Bergmann, Carol J. Saunders, Magdalena Krygier, Diana Carrasco, Kay Metcalfe, Stephan J. Sanders, David Y. Zhang, Renae Judy, Wes Nijim, David Exposito-Alonso, Christine X. Deng, Jusung Kim, Jozef Gecz, Corrado Romano, Cindy Skinner, Angie Lichty, Ellen Linebaugh, Steven A. Skinner, Maria Chahrour, Tianyun Wang, Kun Xia, Hui Guo, Sien Van Daele, Gert Van Goethem, Christina Fagerberg, Jesper Graakjaer, Susanne Anders, Heike Fink, D Isum Ward, Dorothy K. Grange, Alanna Strong, Petra Zwijnenburg, Meghan Towne, René G. Feichtinger, Jennifer Morrison, Aditi Dagli, Jonathan Levy, Yline Capri, Rebecca C. Spillman, Sarah Hart, Vandana Shashi, Boris Keren, Tjitske Kleefstra, Rolph Pfundt, Christian Gilissen, Evan E. Eichler, Melanie Brugger, Michael Zech, Wendy K. Chung, Maria Fasolino, Holly C. Dow, Daniel J. Rader, Edward S. Brodkin, Maja Bucan, Eric D. Marsh, Caroline Dias, David C. Fajgenbaum

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: TCF7L2 (OMIM 602228; HGNC:11641) is a transcription factor and a critical effector of the Wnt/ β-Catenin pathway. In 2021, 11 pediatric patients with monoallelic predicted loss-of-function (pLOF) TCF7L2 variants and syndromic features were observed. Characterization of patients with pLOF TCF7L2 variants and neurodevelopmental features-herein referred to as TCF7L2-related neurodevelopmental disorder-is urgently needed.

METHODS: We leveraged multiple methods (eg, GeneMatcher, DECIPHER, literature review, and public/private repositories) to identify an international cohort of 76 patients with pLOF TCF7L2 variants and neurodevelopmental features and phenotypically characterized them. We also retrospectively searched for an independent cohort of adults with pLOF TCF7L2 variants (n …

High-Grade Astrocytoma With Piloid Features: A Clinical And Genomic Analysis Of Prognostic Factors Using A Large Cohort, Shuodan Zhang, Omar H Butt, Sonika Dahiya, Et Al.

2020-Current year OA Pubs

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well understood. Prognostic factors of clinical outcomes are not well established.

METHODS: Methylation profiling was performed on tumor samples, many at the National Cancer Institute (NCI) Laboratory of Pathology, and others from publicly available sources. Methylation classifier scores of ≥0.90 to the HGAP class on the NCI-Bethesda classifier version 3 were included. Clinical features were collected from the medical record. Survival analyses were performed using the Kaplan-Meier and Cox-proportional hazards methods.

RESULTS: The cohort comprised 421 patients. There were high rates of ATRX alteration …

Efficacy And Safety Of Frail Patients Treated With Ciltacabtagene Autoleucel In The Real World: A Center For International Blood And Marrow Transplant Research Analysis., Hira Mian, Muhammad Salman Faisal, Tiening Chen, Ruta Brazauskas, Temitope Oloyede, Nausheen Ahmed, Aimaz Afrough, Larry D Anderson, Rahul Banerjee, Jesus Berdeja, Aram Bidikian, Jakob Devos, Binod Dhakal, Ajoy Dias, Danai Dima, Yvonne A Efebera, Lohith Gowda, Doris K Hansen, Hamza Hashmi, Heather J Landau, Lazaros Lekakis, Abu-Sayeef Mirza, Ravi Narra, Krina Patel, Ashley E Rosko, Mark Schroeder, Surbhi Sidana, Saad Usmani, Marcelo C Pasquini, Taiga Nishihori, Othman Salim Akhtar, Meera Mohan

Oncology Articles

Background: Ciltacabtagene autoleucel (cilta-cel), an anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR-T) therapy, is approved for relapsed/refractory multiple myeloma (RRMM).

Methods: Using the Center for International Blood and Marrow Transplant Research registry, this study evaluated outcomes of frail patients receiving commercial cilta-cel from March 2022 to December 2023. Frailty was defined by an adapted simplified score incorporating age, performance status, and comorbidities.

Results: Among 541 patients with available frailty status, 183 (33.8%) were frail and 358 (66.2%) were nonfrail. Overall response rates were comparable (frail 82.8% vs. nonfrail 88.5%). However, frail patients had inferior progression-free survival (PFS) (12-month …

Induced Membrane Reconstruction Of A 6-Cm Ulnar Defect With Concurrent Revision Bone Grafting Of Radial Nonunion Following Gustilo-Anderson Type Iiib Open Forearm Fracture: A Case Report., John N Manfredi, Abdullah B Chandasir, Mitchell Lomis, Brent Prenger, Humzah Ali, Kyra Urquhart-Foster, Caleb J Bischoff, Abrar Adil Ansari

Surgery Articles

The induced membrane technique (IMT) is a two-stage reconstructive procedure for critical-sized bone defects. We report a 31-year-old male who sustained a Gustilo-Anderson grade IIIB open fracture of the radius and ulna following a high-energy dirt bike injury, complicated by Serratia marcescens fracture-related infection and septic nonunion. Intraoperative debridement at Stage 1 revealed a 6-cm defect of the ulna, which was managed with an antibiotic-impregnated polymethylmethacrylate (PMMA) spacer. A concomitant radial nonunion, identified on postdebridement CT, was addressed at Stage 2 with concurrent revision open reduction and internal fixation (ORIF) and autogenous femoral bone grafting. Culture-directed oral antibiotic therapy was …

Clinical Decision Support For Fall Prevention In Primary Care: The Esteps Cluster Randomized Clinical Trial, Nancy K Latham, Erin Hommel, Mackenzie Kiesman, Stuart R Lipsitz, David W Bates, Diane L Carroll, Alexandra C Frost, Pamela M Garabedian, Julia V Loewenthal, Michael Sainlaire, Lipika Samal, Wenyu Song, Matthew Wien, Patricia C Dykes

Faculty, Staff and Students Publications

Importance: Falls are a leading cause of injury among older adults. Although exercise reduces fall risk, implementation in primary care remains limited.

Objective: To assess whether an electronic health record-integrated clinical decision support intervention, Electronic Strategies for Tailored Exercise to Prevent Falls (eSTEPS), reduces falls among older primary care patients at increased risk.

Design, setting, and participants: This matched-pair cluster randomized clinical trial was conducted from June 9, 2023, to May 8, 2025, with 12 to 23 months of follow-up at primary care practices within an integrated health system in the US. Adults aged 65 years or older with a …