Digital Commons Network^™

Regulation Of Weak Acid-Dependent Cell Death By The Msaabcr Operon During Biofilm Formation Of Staphylococcus Aureus, Sarah-Elizabeth M. Polley

Honors Theses

Staphylococcus aureus is a dangerous human pathogen and a leading cause of both nosocomial and community-associated infections. Infection by S. aureus is a growing health concern due to the emergence of antibiotic resistance and the capability to form robust biofilms. Major constituents of the biofilm extracellular matrix are demonstrated to be released via controlled autolysis of a subpopulation of the biofilm. As indicated in past studies, the programmed cell death (PCD) of S. aureus grown in a biofilm microenvironment is potentiated by the buildup of acetate, a byproduct of glucose metabolism, which causes cytoplasmic acidification. Furthermore, it has been shown …

Examining School Safety And Security: A Situational Crime Perspective, Jessica A. Barnett

Honors Theses

In recent years, an interest in focus of research addressing school safety and security has increased; however, this literature lacks a cohesive theoretical perspective for addressing solutions to school crime and violence. The purpose of this study was to perform a systematic review of the literature on school safety and security. Then, analyze this literature in light of the situational crime prevention perspective. A literature search using Web of Science yielded 45 eligible studies. Results indicated that each of the 45 articles could be organized into one of the five mechanisms of Situational Crime Prevention: increasing effort, increasing risk, removing …

The Cultural Influence On Sharing Economy Services: The Case Of Airbnb, Lacey K. Wallace

Honors Theses

The sharing economy offers consumers an alternative to ownership by exchanging value through technology-based services. As sharing economy practices continue to emerge, business scholars have only recently begun to study how cultural differences impact the sharing economy. Specifically, few studies have examined individual cultural values. Therefore, this study explores whether differences in cultural values, using Hofstede’s cultural dimensions, account for consumers’ attitudes and participation in sharing economy services (SES). Utilizing a survey, data was gathered from a total of 276 consumers from Amazon’s Mechanical Turk (MTurk) who had previous experience with Airbnb, a popular peer-to-peer accommodation SES. Multiple regression was …

Perturbation Of Lagrange Points In Effective Potential Simulations, Swapnil Bhatta

Honors Theses

Lagrange points are analytically proven to exist at certain positions in a two-body gravitational system, simply as a function of the gravitational force governing the motion of the bodies and the centrifugal potential due to rotation, providing regions of varying effective potentials. In a system involving interactions between the gravitational forces of multiple bodies however, the position of the Lagrange points ought to change. The purpose of this research project is to verify that the change does indeed occur when a new body is introduced, and compute the perturbation in the position of these points given various parameters.

Ptsd Symptoms And Alcohol-Related Outcomes In College Students: The Mediating Role Of Positive And Negative Coping Styles, Tatum Freeman

Honors Theses

This study evaluated the mediating role of coping styles (problem-solving and avoidance coping) on the relationship between posttraumatic stress disorder (PTSD) symptoms and alcohol outcomes (i.e. hazardous drinking and alcohol-related negative consequences [ARNC]). A national sample of 672 traditional age (i.e. 18-25 years old; M = 22.35, SD = 1.97) college students who reported alcohol consumption in the past month were recruited via Amazon’s Mechanical Turk website. Participants were 55.1% male and 60.9% White, and they completed measures of PTSD symptoms, coping styles, hazardous drinking, and ARNC. Problem-solving coping (an adaptive form of coping) mediated the positive relationship between PTSD …

Discriminating Azo Dyes: Conjugated Polymers, The Inner Filter Effect, And Array Sensors, Erin Crater

Honors Theses

Azo dyes are abundant pollutants that contaminate water supplies and threaten humans, biota, and ecosystem health. Their detection and discrimination are an incredible challenge due to the structural, chemical, and optical similarities between dyes, the complexity of the wastewater environment in which they are found, and their low environmental concentrations. In this work, the inner filter effect (IFE), combined with conjugated polymer array-based sensing, is utilized for the quantitative profiling of these pollutants. The array was constructed using three fluorescent, anionic conjugated polyelectrolytes whose varying spectroscopic properties led to distinct IFE patterns in the presence of the dyes. The unique …

The Pain In Beauty, Kededra C. Brown

Honors Theses

Conducting research in a creative field is different from that of an academic field such as a biological science or history. Instead of constructing a thesis topic and question, then conducting research to answer said question, one has to come up with a concept and then expound upon that basic idea. This is done through the use of information on the subject and the setting of the given idea. This thesis is a production book for a screenplay titled The Pain in Beauty (2020). A production book is a series of documents that contain all the details of the pre-production …

Assessing The Effect Of Bile And Oxygen Availability On The Redox Status Of Listeria Monocytogenes Strain F2365, Sukriti Bhattarai

Honors Theses

Although bile is a bactericidal agent able to disrupt membrane structure and cellular homeostasis, including the induction of oxidative stress, Listeria can tolerate bile and also utilize it as a signal to enhance infection and virulence. Preliminary findings showed that under anaerobic conditions, exposure to bile significantly lowered the amount of oxidative damage present in bile-resistant strain F2365 cells. Similarly, Listeria further elicits an adaptive immune response, wherein pre-exposure of the bacterium to stress during food processing or in the host prior to entry into the intestine increases bile tolerance. Based on these previous studies, we hypothesized that bile induces …

‘I Want It, I Got It’: Cultural Appropriation, White Privilege, And Power In Ariana Grande’S “7, Alyssa T. Bass

Honors Theses

Black women often suffer from not receiving recognition for their work. Still, nonblack people continue to use black women’s contributions to pop culture to rebrand themselves. This is especially relevant in the music industry. Cultural appropriation is the act of a dominant group taking cultural elements from a minority group without acknowledging the cultural significance of those elements. The counterpublic Black Twitter gives black Twitter users the space to hold appropriators accountable. I used Grounded Theory to analyze tweets about Ariana Grande’s “7 Rings” to explore how Black Twitter responded to Grande allegedly appropriating black women for financial gain. Critical …

Generating Zika Vaccine Candidates Using Nhumirim Virus As A Backbone, Mariam A. Atobiloye

Honors Theses

Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is causing significant world-wide health concern. There are currently no treatments or vaccines available for this virus, thus, there is an urgent need to develop a safe and effective vaccine to combat ZIKV infection. Nhumirim virus (NHUV) is also a mosquito-transmitted flavivirus, but it is unable to infect humans and other vertebrate animals, making it an ideal candidate to develop chimeric viral vaccines against other disease-causing flaviviruses, such as ZIKV. In this study, we generated chimeric viruses by replacing envelope (E) gene in the genome of NHUV with ZIKV E gene, which …

Co-Assembly Behavior Of Neutral And Zwitterionic Amphiphilic Block Copolymers In The Fabrication Of Glassy Polymer Vesicles, Elina Ghimire

Honors Theses

Polymersomes, also known as polymer vesicles, are hollow capsules fabricated through the solution assembly of amphiphilic block copolymers. Polymer vesicles have garnered a great deal of interest in materials science because of their potential application in areas such as drug delivery, diagnostics and imaging, gene therapy, and as nanoreactors. The goal of this project is to understand the factors that affect the arrangement of triblocks in vesicle membrane via the study of the co-assembly behavior of linear amphiphilic triblocks with different hydrophilic blocks. We investigated the self- and co-assembly behavior of amphiphilic triblock copolymers with neutral hydrophilic blocks. Moreover, we …

The Effect Of Truncated Complement Constructs On Biofilm Formation, Protease Production, And Pigmentation, Cara L. Cothern

Honors Theses

The msaABCR operon regulates virulence factors in Staphylococcus aureus, a Gram-positive commensal organism that colonizes healthy individuals but can also be a human pathogen. These virulence factors include biofilm development, pigmentation, and extracellular protease production. The operon consists of the msaB gene, which produces a coding transcript, the msaA gene and the msaC gene, which produce noncoding RNAs, and msaR, which produces an antisense RNA. The latter three transcript regions of the operon are referred to as untranslated regions (UTRs) and are essential for the function of the operon, but only msaB encodes a protein. The mechanism of …

Impact Of Salt Deduction Cap On Individual Tax Liability, Mahum Chaudhry

Honors Theses

The Tax Cuts and Jobs Act of 2017 placed a cap of $10,000 on the State and Local Tax deduction. A survey was carried out to compare individuals' tax liability in 2017 (before the cap) with their tax liability in 2018 (after the cap). The results suggest that fewer people itemized in 2018, and most belonged to the high-income group. Many individuals who itemized in 2018 also saw an increase in their federal tax liability. Most individuals with less than $100,000 yearly income opted for the standard deduction and saw a decrease in their federal tax liability in 2018 (in …

The Typewriter And The Literary Sphere: An Analysis Of Turn-Of-The-Century Literature, Emma K. Holdbrooks

Honors Theses

My thesis explores the typewriter’s impact on early 20^th century American literature. By providing authors with the means to produce work accurately and effectively, the typewriter changed the process of writing. Typewriters also created job opportunities for women, who often served as typists. The typist became the foothold position that changed America’s perception of women in the work force and helped usher in a new social concept, “the New Woman.” To illustrate my claim, I show how the typewriter allowed poets like E. E. Cummings to experiment with spacing. Cummings made the typewriter’s standardization of text and spacing into …

Alpha-Gal Syndrome: Molecular Characterization Of Amblyomma Americanum Α-D-Galactosidase In Α-Gal Metabolism And Onset Of Red Meat Allergy, Ahmed A. Mohamed

Honors Theses

Tick-borne red meat allergy is an IgE-mediated delayed hypersensitivity reaction, increasingly widespread in tick endemic areas in the United States of America, and worldwide. Bites from the lone-star tick (Amblyomma americanum) are believed to be involved as the source of the sensitization of humans to the oligosaccharide galactose-⍺-1,3-galactose (α-gal), which is found in most mammal-derived food products, including gelatin, broths, and red meat. The purpose of this study is to functionally characterize the lone-star tick α-D-galactosidase (AGS) enzyme and assess its role in α-gal metabolism. This enzyme cleaves terminal α-galactose moieties from glycoproteins and glycolipids. Hence, I hypothesized …

“Part Of That (Man’S) World”: Analyzing “Cinderella” And “The Little Mermaid” Fairy Tale Variants Through A Feminist Lens, K. Morgan Mitchell

Honors Theses

Fairy tales are often reduced to nothing more than the moral lesson that can be taught to children. However, when we move past the impulse to search for the simplified moral of the story, we can begin to ascertain the impact of fairy tales on different audiences. This thesis uses both impact theory, which yields a close reading of the textual and cinematic evidence, and reception research, which provides an opportunity to discuss the significance of the material by speculating about the message that readers receive. Under consideration are four variants each of the “Cinderella” and “The Little Mermaid” fairy …

Learning To Love Bats, Bethany J. Lawson

Honors Theses

Throughout history, bats have often become entangled in various myths and legends that have negatively influenced human perceptions of bats. Media outlets often sensationalize the relationship of bats to novel diseases, which also creates negative perceptions of bats in the human imagination. Bats are beneficial to our ecosystems and provide pollination services, seed dispersal, and insect control. However, bats are currently facing a variety of life-threatening issues, such as habitat destruction, fatalities at wind energy sites, climate change, and most notably, white-nose syndrome – a disease that has killed millions of North American bats in the past decade. With bats …

An External Expression Of The Inner Spirit: Dance, Religion, And Taboos In Christianity, Erin E. Ingram

Honors Theses

Dance, religion, and the presence of taboos have each been recognized as what is known throughout the social sciences as “cultural universals.” For example, though not every individual dances, dance can be found in all societies (Brown, 2004). Furthermore, many cultures use dance as part of religious or ritual worship. The following thesis explores possible answers to these three intertwined questions: “Many cultures across the world have developed dances for the purpose of religious or spiritual rituals and celebrations. Does dance as a form of expression stem from a biological, spiritual, or cultural need? Why do cultures turn to dance …

Assessing The Role Personality Plays In Puppy Raisers And Guide Dogs In Training, Cassidy D. Wood

Honors Theses

Several factors affect how guide dogs in training fare during the period before the dogs are paired with their future handler. One factor that has not been researched in the past is personality compatibility between the puppy raiser and the dog in training. For the needs of the visually impaired community to be met, guide dog schools need to efficiently train and match dogs to handlers without the dogs failing. To help reduce the number of dogs that fail guide dog training, this study suggests the assessment and comparison of personality for the dog and potential puppy raisers to better …

Evolving Crisis Communication In Social Media Era: Analysis Of Tweets And News Stories Of The Manchester Arena Bombing, Allyson R. Staton

Honors Theses

The purpose of this research study was to better understand the evolving crisis communication methods used on traditional media and social media following organizational crises such as the Manchester Arena bombing. The research was primarily conducted by analyzing the British Broadcasting Corporation (BBC) online article archives and stakeholder Twitter accounts, including @ManchesterArena, @ManCityCouncil, @ArianaGrande and @GMPolice. Tweets under the hashtags #ManchesterBombing, #Manchester, #OneLoveManchester as well as the Manchester Bombing Twitter Moment were also analyzed for crisis communication responses to understand how traditional media and social media were used to communicate with the public following this crisis.

The results of this …

Determining The Association Between Religious Participation And Spirituality And Diet And Physical Activity Behaviors In African Americans Of Mississippi, Nidhi Shrestha

Honors Theses

According to CDC, African Americans experience higher rates of chronic diseases when compared to other ethnic groups. Focusing on religiosity and spirituality may benefit the health status of this minority group where advanced healthcare facilities are not easily assessable. The purpose of this research is to 1. Examine demographic factors related to religiosity/spirituality factors among a sample of African American Mississippians; and 2. Determine the correlation between their religiosity, spirituality, and health behaviors. The study uses the data collected by the Mississippi INBRE Telenutrition Center at The University of Southern Mississippi (USM). Participants for this study were recruited from May …

Crime Television Viewership And Perceived Vulnerability To Crime Among College Students, Madison S. Seymour

Honors Theses

This study focused on college students’ viewership of the crime drama television shows NCIS, Law and Order, Criminal Minds, and CSI as well as students’ perceived vulnerability to crime. The aim of the study was to determine if there is a relationship between the viewing of crime dramas and perceived vulnerability, based on the theories of mean world syndrome and cultivation. The study also examined the platform viewers used to watch crime dramas, whether that was streaming services or other options such as cable or satellite television. The chosen platform was also compared with perceived vulnerability to crime.

To collect …

Tailoring Photodegradation Rates Of Acetal-Containing Polymer Networks, Michael Sandoz

Honors Theses

In this thesis, we explore the degradation of poly (thioether acetal) thermosets via a photoinduced thiol-catalyzed ß-scission of acetal linkages incorporated as network crosslink junctions. Specifically, a library of bis-allyl acetal-containing monomers derived from para-substituted benzaldehydes was synthesized and formulated into photopolymerizable thiol-ene resins with commercially available thiol monomers. By varying the electron donating or withdrawing nature of the monomer substituent, we explored the impact of substituent effects on the rate of polymer degradation. Furthermore, we compare the results to those expected from a classical Hammett-type relationship of substituent electronic effects. FTIR was employed to track the appearance of the …

Cloning And Expression Of Human Synaptosome Associated Protein 29 In E. Coli, Logan M. Ryals

Honors Theses

Acting as the chief mediators of vesicular fusion, soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) play a role in many intracellular trafficking events by moving opposing membranes into close proximity. One such event takes place in the process of autophagy. A key SNARE involved in autophagy is Synaptosome Associated Protein 29 (SNAP-29), which acts on the autophagosome membrane to promote autophagosome and lysosome fusion. Kaposi’s Sarcoma Herpesvirus (KSHV) proteins ORF33 and ORF38 were demonstrated to interact with SNAP-29. The exact mechanism of this interaction is yet to be elucidated but it is hypothesized that these interactions allow KSHV to modulate …

Assessing The Impact Of Factional Infighting Within Boko Haram, Paul Markos

Honors Theses

The emergence of Boko Haram in West Africa has resulted in severe disruption of the Lake Chad region and the displacement of millions. In 2015, Boko Haram pledged allegiance to ISIS, signaling a shift in the organization’s objectives and adopting a new strategy for influence over its region. Subsequent leadership changes led to the group’s splintering into multiple factions. Infighting between and within factions has raised new questions imperative to understanding the group’s outlook. This paper sought to examine the impact that deaths of ISIS and ISWAP leaders have on the outlook of Boko Haram and its factions (JAS, Ansaru, …

Why Families Flee: A Study Of Family Migration Patterns From The Northern Triangle Of Central America, Claire Williams

Honors Theses

The past decade has witnessed an unprecedented increase in migrant families from the Northern Triangle, the region of Central America comprised of El Salvador, Guatemala, and Honduras. The mass influx in family migration has important consequences for destination countries like the United States and Mexico as well as the countries which they leave behind. This study aims to answer the question of how family migration patterns in the Northern Triangle of Central America have changed in the past decade and why. I outline the migration decisions of families through a qualitative and quantitative lens. I use newspapers and NGO reports …

Brief Survey And Testbed Development For Blockchain Based Internet Of Things, Aishwant Ghimire

Honors Theses

Blockchain and the Internet of Things are uprising in today’s technology world. Internet of Things or IoT are the devices with unique identifiers that share data or information over the internet whereas, Blockchain is a peer to peer network with a distributed ledger that contains a list of blocks that are linked together by cryptography. Fascinated and motivated by blockchain and Internet of Things (IoT), this thesis provides a review on blockchain based internet of things and also introduces a working testbed that integrates the two together. It also uses IoT device to invoke transactions into the blockchain. The reasons …

Financial Accounting Case Studies, Paul Andress

Honors Theses

This thesis is a combination of twelve different accounting case studies. These cases represent a culmination of two semesters’ worth of research on various topics that will help my career as an accountant. The cases range from company case studies to in-class activities including an excel certification course. The cases caused me to think critically about topics that affect the accounting profession which are not typically covered in my accounting course work. For example, the cases investigated Brexit, the financial crisis of 2008, and universal basic income. Also, the cases provided me with advice through interviews with experienced people in …

Applying International Law To The Regulation Of Media Incited Genocide: Rwanda And Myanmar, Savannah Whittemore

Honors Theses

The goal of this thesis is to demonstrate the connection between word and action in relation to the media incited genocide. By employing the operational definitions of intent, incitement, genocide, and hate speech from legal texts such as the Genocide Convention and the International Covenant on Civil and Political Rights, this thesis shows that there is suitable jurisprudence on the crime of direct and public incitement to genocide with the legal bodies statute mirrors the language of the Genocide Convention. This in conjunction with the language gradient on the changing role of messages before and during genocide shows that regulation …

Raman Spectroscopic And Quantum Chemical Investigation Of The Effects Of Tri-Methylamine N-Oxide (Tmao) On Hydrated Urea, Hydrated Guanidinium, And Hydrogen Bonded Networks, Genevieve Verville

Honors Theses

Trimethylamine N-Oxide (TMAO), guanidinium, and urea are three important

osmolytes with their main significance to the biophysical field being in how they

uniquely interact with proteins. TMAO is known to stabilize and counteract the

destabilizing effects of both urea and guanidinium. The exact mechanisms by which

TMAO stabilizes and both guanidinium and urea destabilize folded proteins continue

to be debated in the literature. Some studies suggest that solvent interactions do not

play a large role in TMAO’s stabilizing effects and therefore advocate direct

stabilization, whereas others suggest that TMAO counteracts denaturation primarily

through an indirect effect of strong solvent interactions. …