Digital Commons Network^™

Yellow Jack's Wrath: The 1878 Yellow Fever Epidemic And Public Health In Mississippi, Kyle Winston

Honors Theses

No abstract provided.

Characterizing Borrelia Burgdorferi In Virginia : Lyme Disease Prevalence As A Matter Of Bacterial Genetic Variation, Hannah Cornman

Honors Theses

yme Disease (LD) incidence and spatial distribution has grown dramatically in the past 20 years. In Virginia, the growth has been especially drastic, primarily in the Western part of the state. This research project investigates how genetic variability of the Lyme Disease causing bacteria, Borrelia burgdorferi, might be contributing to this increase in LD incidence in western Virginia. To do this, B. burgdorferi samples were isolated from ticks found across the state and were characterized by multilocus sequence typing (MLST). Phylogenetic and minimum spanning tree analyses were also performed. It was hypothesized that the increasing number of Lyme disease infections …

Interactions Between Two Key Amphibian Defenses To Batrachochytrium Dendrobatidis In Panamanian Glass Frogs (Espadarana Prosoblepon), Andi Levorse

Honors Theses

Research on the amphibian pathogen Batrachochytrium dendrobatidis (Bd), the causative agent of the lethal disease chytridiomycosis, has advanced from assessments of pathogenicity and species susceptibility to more specialized questions concerning the complex interactions between the pathogen, species-specific immune responses, and the environment. Our work examines the potential for interactions between the two most important innate immune defenses of frogs against Bd: secretions of antimicrobial peptides and communities of commensal cutaneous bacteria. While both defenses have been studied individually, little data are available to examine interactions between these defenses. We conducted our study with field captured Panamanian glass frogs …

Community Structure Of The Microbiome Of Ixodes Scapularis In Relation To Sex, Stage, Lineage, And Geography, Christopher Lee Clark

Honors Theses

This study sought to fill these gaps of knowledge ticks as a model species. Based on the known information on the microbiome of vectors, and ticks more specifically, I sought to answer two prominent questions: are there relationships between the microbiome of individual ticks and do ticks from different sexes or life stages have variance in their microbiomes? In reference to my first question, I hypothesized that ticks coming from the same lineage, being the males, 7 Community Structure of the Microbiome of Ixodes scapularis females, and resulting eggs, would have a more similar microbiome to each other than to …

Method Development And Pharmacokinetic Study Of Jy08, A Dual Opioid-Npff Receptor Ligand, Sydney Harrison

Honors Theses

Within the United States and worldwide, a rapidly developing public health crisis is at hand due to the abuse of opioids. With high percentages of Americans experiencing both acute and chronic pain and limited treatment routes, opioid analgesics are highly prescribed in clinical practice. These drugs act on central nervous system to activate opioid receptors in regions of the brain regulating pain and reward. However, these compounds are associated with many unwanted adverse effects including tolerance, dependence, hyperalgesia, and addiction. Thus, there is a need to for the development of new drug candidates that can serve as analgesics for long-term …

The County-Level Impact Of Telemedicine: A Difference-In-Differences Analysis Of The University Of Mississippi Medical Center's Telemedicine Initiatives, Megan Elise Mcleod

Honors Theses

Mississippi has the fewest active physicians per capita of any state, consistently struggles with high rates of acute and chronic illness, and over half of its residents live in rural areas lacking specialty medical care. In an effort to bridge the state's geographical gap in access to healthcare, the University of Mississippi Medical Center (UMMC) has introduced telemedicine. This study conducts an analysis of some of the societal benefits of UMMC's telemedicine initiatives using a difference-in-differences identification strategy. This model attempts to obtain the county-level causal effects of implementing telemedicine by evaluating the resulting changes in length of life, quality …

Evaluation Of New Antimalarial Drug Combinations, Robert Tyrone Higginbotham

Honors Theses

Malaria is a disease that has affected people throughout the world for centuries and is still responsible for over 200 million clinical cases per year. While a number of developed countries have eradicated the disease, its prevalence in tropical regions poses a significant global health challenge. The disease is caused by the Plasmodium genus, an obligate, intracellular parasite that is carried by the female Anopheles mosquito. While there are effective antimalarial drugs in clinical use, Plasmodium's resilient nature has allowed it to develop resistance to multiple drugs. This fact makes it imperative to seek out novel drugs to combat resistant …

Social Evils + Stigma: A Cumulative Study Of Hiv And The Moral Model Of Disease In Vietnam, Argentina And Mississippi, Sarah Thornby Stroup

Honors Theses

How can studying such diverse contexts as Vietnam, Argentina, and Mississippi—three cases from opposite corners of the world — provide remediation for the global HIV epidemic? By targeting specific populations of high-risk groups (e.g. injection drug users, females sex workers, and men who have sex with men), analysis of my ethnographic fieldwork in Vietnam, Argentina, and Mississippi, revealed a common denominator of stigma, though manifesting in varying ways, which laid the foundation for this thesis. Building from Erving Goffman's (1993) foundational text on stigma in collaboration with Link and Phelan's (2001) expansion thereof, I define stigma as the differentiation and …

Development Of A Scn1a Null Zebrafish Model For Screening Potential Anti-Epileptic Natural Products, Patricia Ann Lipson

Honors Theses

Epilepsy affects around 50 million people in the world. Thus, it is imperative that new more effective and safe treatments be found. This study was designed to use zebrafish to screen potential anti-epileptic natural products. We utilized two scn1Lab null zebrafish models (morpholino-injected fish where scn1Lab was transiently knocked down and a transgenic scn1Lab -/- fish line). Alternatively, we used AB wildtype fish to test compounds in a chemically-induced seizure model. Natural compounds including cannabidiol, CBD, and Tapinanthus globiferous, TG, extracts were screened for their anti-seizure activity. When scn1Lab -/- fish were treated with CBD (0.075 and 0.3 mg/L) from …

Elder Care In Chile And The Us: Two Models Of Culture Change, Sarah Jane Robinson

Honors Theses

This project examines two long-term care models: the Green House Project model and the Little Sisters of the Poor Home for the Aged in Viña del Mar, Chile, under the lens of the long-term care culture change movement to explore what can be learned from each of these models to allow elders to grow in dignity and autonomy. The research methods used were primarily participant and non-participant observation, informal interviews, and review of social scientific and gerontological literature. Elements of culture change were found to be present in each model, both of which aim to provide person-centered care to elders. …

Housing Policy Alternatives For The Lafayette-Oxford, Mississippi Community, Alice C. Norman

Honors Theses

This thesis explores housing policy alternatives to address housing insecurity in the Lafayette-Oxford, Mississippi community and similar non-metropolitan communities which are experiencing accelerated growth. Policy alternatives were collected through a systematic literature review of the University of Mississippi's One Search database. Findings reveal that there are a number of housing dynamics in U.S. cities which require different considerations in regards to policy alternatives. Policy alternatives discussed range from subsidized affordable housing, the removal of regulations on new developments, social housing, voucher programs, rent control, creating city connections, unemployment insurance, community land trusts, shifting responsibility to a higher level of government, …

Vibrio Vulnificus Monitoring Along The Coastal Bend And The Rio Grande Valley, Texas, Louay Bachnak

Honors Theses

Vibrio vulnificus is a common opportunistic pathogen found in marine, coastal, and estuarine waters. This one micrometer microorganism is the leading cause of deaths in the United States due to food poisoning after consumption of raw or undercooked seafood. The optimal temperature for survival is between 15.6°C and 35.0°C with moderate salinities – conditions frequently found in the Gulf of Mexico (Lin, Payne, & Schwarz, 2003).

In the United States, V. vulnificus infections are more common in states bordering the Gulf of Mexico, including Texas. However, infections can still occur in individuals consuming infected food more inland or sustain wounds …

An Analysis Of Prevalence Of Chytrid Fungus In An Amphibian Assemblage In Middle Tennessee, Cameron Brocco

Honors Theses

Chytridiomycosis is an infectious, fungal disease largely seen in amphibians, which is caused by the highly virulent, zoosporic, pathogenic, single-celled fungus Batrachochytrium dendrobatidis (Bd). It is known to cause epidermal hyperplasia, hyperkeratosis, skin ulcerations, and fatalities by asystolic cardiac arrest either from shifts in electrolytes or increased acidity in the blood plasma. Previous research has demonstrated that urban water bodies have a higher prevalence of chytrid fungus than rural water bodies. Researchers have also found that chytrid is more prevalent in open canopy habitats than closed canopy habitats. Furthermore, it is implicated in global population declines and local extinctions in …

Symptoms, Infectious Pathway, Treatment, And History Of Rabies In The United States, Paul Beckman-Ellenwood

Honors Theses

Rabies is a virus of the Lyssavirus family that is endemic to almost all parts of the world and claims over 55,000 lives every year. The virus is capable of being vectored through any warm-blooded animal and has a variable incubation time in its hosts. Once the disease finishes incubating and symptoms appear in the host, the disease is always fatal to humans. To prevent this there are several treatments available, but they can be expensive or difficult to obtain in parts of the world that have the most problems with rabies. To solve this vaccines have been created to …

My Journey To Better Medicine: Healing The Mind-Body Split Through An Integrated Cross-Cultural Model, Harsh Ilapakurthi

Honors Theses

As a future medical doctor, I will always see the process of healing through the hybrid consciousness of my Eastern-Hindu upbringing and Western academic and scientific training. The Eastern philosophy of healing has been linked to consciousness and how the powers of human consciousness can affect the body’s healing. The Western perspective of medicine, which has developed as a result of the industrial and scientific revolutions, generally treats the human body as an object. However, this is not to say that Western medicine is flawed. In fact, Western medicine is incredibly effective in certain specialties, but is limited by the …

A Retro Development In Education: Evaluating The Feasibility Of Integrating Place-Based Education Into Mississippi Curriculum Standards, Colby K. Mcclain

Honors Theses

This thesis evaluates the feasibility of integrating place-based environmental education activities from Think Green, Take Action: Books and Activities for Kids into the Mississippi Department of Education’s (MDE) Frameworks for Science and Social Studies for K-5. As children develop and experience the world, their ability to understand and interpret the surrounding environments expand; however, Mississippi schools are not focused on experiential environmental education, even though experiencing and understanding the surrounding environment is vital in fostering eagerness to learn. Due to a growing disconnect between humans and the natural world, this thesis examined 37 place- and environment-based activities for children, sixteen …

The Regulatory Relationship Of Transcriptional Regulators Msab And Cody In Capsule Production In Staphylococcus Aureus, Brittany L. Trunell

Honors Theses

There are many transcriptional regulators found in pathogenic Staphylococcus aureus. Many of these regulators are essential for the organism’s ability to switch from commensal form to the virulent pathogenic form. One of these main regulators is CodY. This regulator has been shown to be responsive to nutrient availability during phases of growth. Additionally, we have recently found that MsaB, the only protein coding ORF of the msaABCR operon, is a putative co-regulator of capsule along with CodY. To explore these regulator interactions, we produced mutations of codY and msaABCR individually and a double mutation of msaABCR/ codY. We have observed …

Nurse Knowledge, Attitude, And Compliance Related To Methicillin Resistant Staphylococcus Aureus, Ellen A. Suss

Honors Theses

The purpose of this study is to determine nurses’ knowledge of Methicillin Resistant Staphylococcus aureus (MRSA), the attitude they have towards patients with MRSA, and how well they comply with MRSA protocols. Forty-six nurses participated in this study. A questionnaire assessing knowledge, attitude, and compliance was distributed via email to graduates of the University of Southern Mississippi. The survey had three sections to assess each variable, with 17 true/false questions about knowledge, 10 questions about attitude, and 6 questions about compliance. Overall, nurses in this study had adequate knowledge of MRSA, aside from overt lack of knowledge regarding antibiotic treatment. …

The Legal Context Of Medicine: Looking At Healthcare Through A Bicultural Lens, Annamarie Beckmeyer

Honors Theses

No abstract provided.

Measuring The Presence Of The Amphibian Pathogen Batrachochytrium Dendrobatidis In East Tennessee, Erin A. Schrenker

Honors Theses

I examined the presence and absence of the amphibian pathogen Batrachochytrium dendrobatidis in three survey areas in Eastern Tennessee. Amphibians were swabbed to assess for Bd and other ecological qualities like canopy cover, and air and water temperature are a few of the measurements evaluated. DNA was extracted from the swabs using a Qiagen DNeasy Blood and Tissue Kit and samples were PCRed in triplicate to confirm presence or absence. All 48 animals that were swabbed in the field were negative for Bd. These results parallel other findings that few Bd positive assays have been conducted in East Tennessee from …

The Msaabcr Operon Mutant Staphylococcus Aureus Is Deficient In Persister Cells, Aaliyah D. Cole

Honors Theses

Persister cells comprise a phenotypic variant that shows extreme antibiotic tolerance resulting in chronic infections. While this phenomenon has posed a great threat in public health, mechanism underlying their formation in Staphylococcus aureus remains largely unknown. Increasing evidence of the presence of persister cells in recalcitrant infections underscores the great urgency to unravel the mechanism by which these cells are developed. The Elasri Research group characterized msaABCR operon that plays roles in regulation of virulence, biofilm development and antibiotic resistance. It was hypothesized that the operon also plays a role in persister cell formation. In this study, the persister cell …

Improving Access To Communication For Adults With Aphasia Using "Aphasia-Friendly" Accommodations, Chandler Hodgkin

Honors Theses

Accessing written health information is vital to any health visit (Blackstone, Beukelman, & Yorkston, 2015). People who have difficulty comprehending written text have difficulty understanding health-related information because it is usually written at a complex levels (Kanj & Mitic, 2009). If health information contains complicated content and is not easily accessible, people may not receive the health care needed (Blackstone et al., 2015). Many populations are considered communication vulnerable relative to health care which means they may not have access to understanding health information documents (Hallowell, 2016). These populations include people who are blind or visually impaired; people who are …

Science And Literature: An Exploration Through A Shared Language, Maura D. Stovall

Honors Theses

Science and fiction are often deemed opposing forces, incompatible “languages” and “cultures.” Science is the realm of fact and reality while fiction is mere fantasy, useless to the rational mind. Yet, the works of Jules Verne, Mary Shelley, Aldous Huxley, H.G. Wells, and numerous others continue to stand the test of time even as scientific knowledge and understanding broaden. Science and fiction, science and literature, are so often thought of as separate, irreconcilable entities and yet science fiction enraptures and intrigues. Science fiction is the playground of science. Where science has not yet or cannot dare to go, science fiction …

Understanding The Patterns Of Distribution And Abundance Of Lyme Disease Carrying Ticks And Their Hosts, Julio Ruiz

Honors Theses

Lyme disease is caused by the bacteria Borrelia burgodorferi and spreads to their hosts by the bites of infected Ixodes scapularis ticks. In the United States, Lyme disease is typically found in the northeast but in recent years the disease has begun to be found further south and west than previously before. Yet, today, little information can be found about the patters of distribution and abundance of ticks and their host. The main goal of this research work was to expand the knowledge of the abundance and distribution of ticks and host. Based on tick collection data obtained from Maikis …

Effectiveness Of A Novel Porphyrin Exhibiting Dark Toxicity Against The Model Organism Mycobacterium Smegmatis, Marissa C. Jama

Honors Theses

Antimicrobial photodynamic therapy (PDT) utilizing porphyrins has emerged as a possible ancillary treatment against antibiotic resistant bacteria. Porphyrins, such a novel zinc containing porphyrin designated ZnP, create reactive oxygen species that are toxic to bacterial cells utilizing light by a mechanism that is not yet fully understood. Previous experiments have shown ZnP to be able to kill microorganisms in the dark which is unique to few porphyrins. The aim of this research is to understand the effect ZnP has on Mycobacterium smegmatis, a model organism for the pathogenic bacterium Mycobacterium tuburculosis which causes the lung infection tuberculosis. Further experimentation is …

The Process Of Reclaiming Tribal Sovereignty Through Healthcare Autonomy, Karolina A. Serhan

Honors Theses

This honors thesis explores the complex interplay between health status, healthcare, and tribal sovereignty among native communities in the United States. These relationships are explored through analyzing the paradoxical and condescending nature of the Federal Trust Responsibility in relation to government-organized healthcare programs for natives. In establishing this relationship, the thesis goes on to illustrate how native communities have effectively fought to regain sovereignty through reclaiming autonomy of their healthcare systems through the use of the 1975 Indian Self-Determination and Education Assistance Act. The impact of tribal-led healthcare systems is further explored through an in-depth case study conducted regarding the …

The Progression Of Lyme Disease In The State Of Virginia, Margaret Michel

Honors Theses

Lyme disease has spread in the United States from the northeast to more southern and western parts of the country. It has been shown that the tick which most often carries the Lyme disease pathogen (Borrelia burgdorferi) in North America, Ixodes scapularis, has also spread to these new areas of concern. In Virginia, the disease has progressed from the eastern shore to the western, more mountainous regions. Through obtaining historical museum specimens of mice from 11 locations in Virginia, we seek to determine whether the Lyme disease causing pathogen, B. burgdorferi, has always been present in …

Impacts Of Aplysina Red Band Syndrome On Secondary Metabolite Profiles And Antibacterial Activity Of The Caribbean Sponge Genus Aplysina, Mafie Claire Vickers

Honors Theses

Coral reef ecosystems continue to decline due to abiotic and biotic factors, including disease. Although much of the existing scientific literature has focused on coral diseases, reports of sponge diseases have been increasing. This is a cause for concern, as sponges are increasingly dominant components of coral reef communities, where they are responsible for a wide range of ecological functions. A sponge disease of particular interest is Aplysina Red Band Syndrome (ARBS), which impacts the Caribbean's most abundant genus of sponges, Aplysina. Three morphotypes of branching sponges within this genus are affected, including Aplysina fulva, and the thin and thick …

Platelet-Derived Microparticles And Their Role In Sepsis, Robert Tramel

Honors Theses

Causing at least 215,000 deaths in the U.S. annually- more than prostate cancer, breast cancer, and AIDS combined- and rising, sepsis is one of the most deadly medical conditions in America. Sepsis pathophysiology, however, is still incompletely understood, making it difficult for physicians to diagnosis and treat effectively. Given the time-sensitivity of treatment, researchers are now searching for new methods to identify sepsis early, developing more accurate prognostic markers, and developing new target therapeutic candidates. One biological component of interest in this research is the platelet-derived microparticle (PMP), a heterogeneous vesicle derived from the cell membrane of platelets found circulating …

On The 路(Lu) To The Loo: A Case Study Of Public Restrooms In China Since The Chinese Communist Revolution, Elizabeth S. Newsom

Honors Theses

This thesis is a case study of China's changing perceptions on privacy, hygiene and sanitation, as well as gender through public restrooms across the three different time periods of the 1950s, the early 2000s, and the 2010s. I analyze the situations, laws, civil codes, and perceptions that lead to different toilet styles. As toilets and defecation are taboo subjects, I use online anonymous resources like Zhihu to discover the modern perceptions of people on today's toilets as well as architecture and statistics. I in part find that I can analyze China's income disparity through toilets as the Coastal region of …