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Articles 241 - 270 of 330
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Healthcare Professionals Knowledge And Attitudes Regarding Biosimilars In Northern Mississippi, Amanda Seals
Healthcare Professionals Knowledge And Attitudes Regarding Biosimilars In Northern Mississippi, Amanda Seals
Honors Theses
The emergence of biologics over the past the past few decades has led to a new interest in the production of a classification of drugs known as biosimilars. The vast complexity involved in the discovery, development, and manufacturing of biologics and biosimilars has made researching the knowledge and perceptions among healthcare professionals important. Healthcare professionals must have an understanding of biologics, as these medications are used for some of the most rare diseases. Healthcare professionals in northern Mississippi were surveyed on their knowledge of and attitudes towards biologics and biosimilars in order to gain insight on the current status of …
A 2-Part Study Examining; Hepatitis B Vaccination Rates Among High-Risk Adults And The Influence Of Education On Knowledge And Awareness Of Hepatitis B And The Use Of Vaccines As A Safe, Preventative Measure Among University Of Ms Students, Ariel Wilson
Honors Theses
Background: Hepatitis B virus (HBV) can be prevented and controlled through vaccination. However, vaccination among high-risks adults in the U.S. is still low (50%). This poses serious threats for HBV transmission between infected individuals and high-risk individuals. Objective: The specific aims of this research were to (a) explore the prevalence of hepatitis B vaccination uptake from 2011-2014 (b) to examine intrapersonal, interpersonal, and organizational level factors associated with receiving hepatitis B vaccination among high-risk adults. Methods: Data were analyzed from the National Health and Nutrition Examination Survey (NHANES) from 2011-2014 to (1) assess the prevalence of hepatitis B vaccination and …
Utilizing The Zebrafish Model To Determine Anti-Epileptic Properties Of Mistletoe And Cannabis, Collin Dietrich
Utilizing The Zebrafish Model To Determine Anti-Epileptic Properties Of Mistletoe And Cannabis, Collin Dietrich
Honors Theses
Epilepsy affects around 50 million people in the world, therefore improving treatment efficacy and safety for epileptics is imperative. In this study we sought to screen the effectiveness and safety of cannabis constituents (delta-9-tetrahydrocannabinol and cannabidiol) and Tapinanthus globiferus extracts in treating epilepsy. We used a zebrafish model wherein seizures were induced by treatment with pentylenetetrazol. Our results showed that Tapinanthus globiferus dose-dependently reduced seizure activity, and no toxicities were seen at the concentrations used. In contrast delta-9-tetrahydrocannabinol and cannabidiol did not significantly reduce seizure activity and some toxicities were seen at the higher concentrations tested. We conclude that extracts …
Pharmacists' Perceptions Of Rapid Diagnostic Testing In Community Pharmacies In Mississippi: A Diffusion Of Innovations Approach, Erin Ann Hoevelmann
Pharmacists' Perceptions Of Rapid Diagnostic Testing In Community Pharmacies In Mississippi: A Diffusion Of Innovations Approach, Erin Ann Hoevelmann
Honors Theses
Objectives: The broad purpose of this study is to describe community pharmacists' perceptions of rapid diagnostic tests (RDTs) in community pharmacies in Mississippi. The focused goal of this study is to determine the correlation between Everett M. Rogers' attributes of the diffusion of innovations (including relative advantage, compatibility, complexity, trialability, and observability) and the willingness of community pharmacists to offer RDTs in community pharmacies in Mississippi. Methods: This study was approved by the University of Mississippi IRB. A list of licensed pharmacists was obtained from the Mississippi Board of Pharmacy. An email with study details and a link to the …
Expression Of Glycine-Rich Proteins Found In Salivary Glands Of The Lone Star Tick (Amblyomma Americanum) Using A Mammalian Cell Line, Annabelle Clark
Expression Of Glycine-Rich Proteins Found In Salivary Glands Of The Lone Star Tick (Amblyomma Americanum) Using A Mammalian Cell Line, Annabelle Clark
Honors Theses
Ticks play an important ecological role as well as a growing role in human health and veterinary care. Ticks are hosts to a plethora of microbial pathogens that can be transferred during feeding to cause tick-borne diseases in humans and many animals. Ticks may in large part owe the success of the transfer of these pathogens between hosts to their complex saliva. The saliva secreted upon a tick’s attachment to a host serves the following, among other, functions: anti-hemostasis of the blood pool, preventing an inflammatory response at the bite site, and serving as a natural anti-microbial substance. An important …
Efficacy Of Benzimidazole Anthelmintics In A Managed Equine Herd In Northeast Texas-- Strategies For An Evidence-Based Targeted Parasite Control Program, Cortney Stewart
Efficacy Of Benzimidazole Anthelmintics In A Managed Equine Herd In Northeast Texas-- Strategies For An Evidence-Based Targeted Parasite Control Program, Cortney Stewart
Honors Theses
No abstract provided.
The Effect Of Increased Exposure Of Uvc Light On Human Skin Microbiota, T'Kylia S. Moss
The Effect Of Increased Exposure Of Uvc Light On Human Skin Microbiota, T'Kylia S. Moss
Honors Theses
Many methods have been employed to prevent infections from opportunistic pathogens in immunocompromised individuals. Among these are the use of ultraviolet light (UV). In this study, UVC light, was found to have a deleterious effect on specific skin flora. Organisms tested included Acinetobacter baumanii, Candida albicans, Candida kefyr, Corynebacterium renale, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus pyogenes. Nutrient agar was used to cultivate most organisms. Blood agar was used for the cultivation of Streptococcus pyogenes and Enterococcus faecalis. Bacterial suspensions were made and utilized to plate each organism onto a set of 7 nutrient agar or …
Computational And Experimental Investigations Towards Improving Organic And Dye-Sensitized Semiconductor Solar Cells, Nathan D. Colley
Computational And Experimental Investigations Towards Improving Organic And Dye-Sensitized Semiconductor Solar Cells, Nathan D. Colley
Honors Theses
The global energy consumption is expected to double by 2050. Therefore, alternative energy sources such as solar power will have to be utilized. This work seeks to improve next generation solar cells, namely organic solar cells (OSCs) and dye-sensitized semiconductor solar cells (DSSCs), using theoretical and experimental approaches. Computational studies were done on electron acceptor and electron donor molecules that have potential use in OSCs and DSSCs. An improved Density Functional Theory (DFT) method that better represents experimental cyclic voltammetry was developed to predict the electronic properties of these molecules. The electronic data of the electron acceptor molecules were used …
The Transfer Of Commensal And Transient Bacteria Into Deep Tissue Using Dry Needling Needles Through Agar Media Designed To Mimic The Elasticity Of Human Skin, Denisse N. Breton Guerrero
The Transfer Of Commensal And Transient Bacteria Into Deep Tissue Using Dry Needling Needles Through Agar Media Designed To Mimic The Elasticity Of Human Skin, Denisse N. Breton Guerrero
Honors Theses
Needle insertion into skin for the purpose of alleviating muscle pain began with the emergence of traditional Chinese medicinal (TCM) acupuncture. “Dry needling”, a recent alternative to acupuncture, involves inserting a monofilament needle down into the deep tissue of a patient’s skin in order to reach the affected muscle. Despite its effectiveness and low risk of infection, dry needling remains questionable with respect to its safety and the lack of research to confirm the low risk of bacterial transmission via the dry needling needles. In this microbiological study, highly concentrated Tryptic Soy Agar was utilized to simulate the elasticity of …
Painless Hematophagy: The Functional Role Of Novel Tick Metalloproteases In Pain Suppression, Joseph W. Jelinski
Painless Hematophagy: The Functional Role Of Novel Tick Metalloproteases In Pain Suppression, Joseph W. Jelinski
Honors Theses
Ticks secrete a plethora of pharmacologically active molecules in their saliva while feeding. These allow the tick to feed upon a host over prolonged periods of time in an itch free and painless attachment. The exact mechanism of pain suppression by the tick has barely been investigated. In this study, two angiotensin converting enzymes (ACEs), members of the metalloprotease family, are identified as potentially responsible for the degradation of pro-inflammatory peptides. It is hypothesized that these tick ACEs block the function of bradykinin through degradation of the peptide, contributing to the tick’s ability to conduct a pain and itch-free host …
Improving The State Of Health Literacy Among American Adults: Why Community Outreach Methods Are More Effective Than Literacy-Level Screenings, Lydia Simpson
Honors Theses
Health literacy refers to an individual’s ability to access and process health information to make important decisions about their health. Unfortunately, millions of American adults have inadequate health literacy skills and are not able to navigate their way through the world of health care. This may lead to disastrous consequences and poor health outcomes. To improve health literacy, nationwide health education programs are imperative. Despite this, low health literacy is often ignored, or only considered for individuals suspected of having low health literacy who might then be administered a screening instrument. A better model for the American health care system …
Impact Of Vector Range Expansion On Pathogen Transmission Dynamics Of Lyme Disease In Southwestern Virginia, Bishan Bhattarai
Impact Of Vector Range Expansion On Pathogen Transmission Dynamics Of Lyme Disease In Southwestern Virginia, Bishan Bhattarai
Honors Theses
Blacklegged ticks, Ixodes scapularis is the primary vector of Lyme disease in eastern United States. Borrelia Burgdorfei, the etiological agent of Lyme disease is transferred by ticks of Ixodes species. In recent years, its congener, Ixodes affinis has been expanding its range northwards from its southern population. We were interested in studying how the introduction of this new vector affected the interaction between the pathogen genotype and the host. We hypothesized that differential host use by I. affinis and I. scapularis would partly explain observed differences in B. burgdorferi infection prevalence and genotypic structure in southeastern Virginia. The result …
Vaccination Situation: A History Of Vaccine Refusal In The United States And Vaccine Beliefs At The University Of Mississippi, Austin Vitale
Vaccination Situation: A History Of Vaccine Refusal In The United States And Vaccine Beliefs At The University Of Mississippi, Austin Vitale
Honors Theses
The goals of this research were to trace a narrative of vaccine refusal in the United States from the nation's inception to the present day and identify any impact or influence from refusal ideology on vaccine beliefs of University of Mississippi undergraduates. A review of historical literature regarding vaccine refusal in the United States developed a historical narrative, and a quantitative survey was utilized to identify the vaccine beliefs of a University of Mississippi sample. Three distinct eras of vaccine refusal were detailed, with the third (present) era distinguished by the use of the internet to spread anti-vaccine ideologies. The …
Perceptions And Attitudes Regarding Preparedness For Campus Crises: A Focus Group Study Of Undergraduates At A Southern University, Christal Davis
Perceptions And Attitudes Regarding Preparedness For Campus Crises: A Focus Group Study Of Undergraduates At A Southern University, Christal Davis
Honors Theses
Objective: To explore student perceptions and attitudes toward disaster preparedness and university readiness for various disasters in order to promote future development of effective strategies to change the culture of preparedness on campuses. Methods: A total of 10 focus groups were conducted with 54 students. Participants completed general demographic information before discussing topics related to preparedness. Results: Findings revealed complacency and lack of preparedness among students for many of the disaster types discussed. Participants reported feeling most prepared for pandemic outbreaks, citing various campus preparedness efforts, while they showed the least amount of confidence in their preparedness for incidents of …
The Evolution Of The Sugarcoated American Food Market And The Paradox Of Artificial Sweeteners, Mary Moses Hitt
The Evolution Of The Sugarcoated American Food Market And The Paradox Of Artificial Sweeteners, Mary Moses Hitt
Honors Theses
Living in present-day America makes it hard to imagine an era when sugar was not as inexpensive and readily available as it is now. It is in little colorful packets on restaurant tables, filled to the brim in jars at coffee shops, or mixed into candy products located at the beginning of every cash register. Today, sugar is one of, if not, the most widely consumed food products in the world, but our love for sugar is nothing new. Humans have been experiencing the bliss triggered by sweet-tasting foods since their earliest diets, which included fruits and honey. Our diets …
Variability In Antibacterial Chemical Defenses In Caribbean Sponges Of The Genus Aplysina, Savannah Stockton
Variability In Antibacterial Chemical Defenses In Caribbean Sponges Of The Genus Aplysina, Savannah Stockton
Honors Theses
Coral reefs represent one of the most diverse ecosystems on earth, providing habitat for at least 25% of all marine species. Coral ecosystems are faced with many stressors, both physical and biological, that are causing their continuing decline. Understanding the impacts of these stressors, and the resilience of coral reefs, is important to the long-term survival of these critical ecosystems. As a major constituent of marine communities, sponges are an important phylum contributing to the ecology of coral reefs. Like other components of coral reef habitats, sponges also face a wide variety of biological stressors including pathogens, predators, and competitors. …
Paleolithic Protection In A Western World: A Look Into Preagricultural Nutrition As A Remedy For The Diseases Of Civilization, Emilie R. Caron
Paleolithic Protection In A Western World: A Look Into Preagricultural Nutrition As A Remedy For The Diseases Of Civilization, Emilie R. Caron
Honors Theses
The aim of this investigation is to discover the associations of the Western diet to noncommunicable diseases and to determine if a reversion to a Paleolithic diet will provide treatment and prevention of these diseases. Noncommunicable diseases, otherwise known as Diseases of Civilization, are lifestyle influenced diseases and encompass obesity, diabetes mellitus, cardiovascular disease, and associated cancers. Incidences of these diseases have skyrocketed in the past century and show no signs of decline. Since 1900, the death rates due to heart disease and cancer have risen to account for 47% of total deaths in the United States in 2010. (Tippett, …
Recommendations For The Development Of New Hospital Guidelines Due To The Effects Of Antibiotics On Clostridium Difficile Colitis, Megan Kohsel
Honors Theses
Clostridium difficile colitis is an infection that causes inflammation of the colon and diarrhea. This can even lead to death in some cases. The incidence of this infection and its overall effects have been on the rise throughout the last twenty years as antibiotics have been prescribed more frequently. Therefore, it is necessary that the rate of C. difficile infection is lowered by improved guidelines for hospitals, so that fewer people are infected and also that fewer antibiotics are prescribed to avoid the infection with C. difficle.
A Comparison Of Gastrointestinal Bacterial Population Between Indoor Cats And Outdoor Cats, Farhana Binti Ikmal Hisham
A Comparison Of Gastrointestinal Bacterial Population Between Indoor Cats And Outdoor Cats, Farhana Binti Ikmal Hisham
Honors Theses
This study used fecal samples from four indoor cats and four indoor-outdoor cats in order to identify the microbial communities in the gut of cats. This information was then used to compare the microbial phyla between both groups for any differences. Total microbial DNA was isolated from each fecal sample, and the 16S rRNA gene was sequenced using Illumina MiSeq high throughput method. The sequences were identified using the bioinformatics program mothur. The results show that indoor cats had a more diverse microbial community as compared to outdoor cats. Indoor cat samples had 26% more microbial species, and eight more …
Plague Inc: Distribution Of Health Resources In The Modern World, Allison Rump
Plague Inc: Distribution Of Health Resources In The Modern World, Allison Rump
Honors Theses
Due to the ever increasing connectedness of our world, disease can spread faster than ever before. Therefore global health care is a pressing issue in the modern world. The Ebola epidemic of 2014, which infected an unprecedented number of people, was reminder of not only of human fragility but of the state modern medicine, especially when deployed in economically developing areas. Not only is medicine about the science and treatment of disease, it also is about economics and the ability to pay for treatment. This can manifest in many forms, for the Ebola epidemic there often were not enough equipment …
Southern Illinois Ticks: An Ecological And Medical Overview, Madeleine A. Pfaff
Southern Illinois Ticks: An Ecological And Medical Overview, Madeleine A. Pfaff
Honors Theses
Ticks are of concern to southern Illinois residents because they are common in the forested landscapes of the region and have the capability to cause disease in humans and pets. There are several tick-borne illnesses of concern to southern Illinois residents. Prescribed burning is a potential method of tick control, but no significant results were found in the correlation of tick density with time since burn.
Factors Affecting Child Mortality, Lisa Wheatley
Factors Affecting Child Mortality, Lisa Wheatley
Honors Theses
This study examines the factors that contribute to the rate of child mortality within a country. Through regression analysis, this model attempts to explain the rate of child mortality for a country as a function of factors including the adult female literacy rate, fertility rates, adult female labor force participation, rate of immunization for tuberculosis, access to safe water, income per capita, and prevalence of human immunodeficiency virus. This paper surveys a range of low-income countries from different regions including Sub-Saharan Africa, Middle East and North Africa, East Asia and the Pacific, Europe and Central Asia, South Asia, and Latin …
Moving The Plague: The Movement Of People And The Spread Of Bubonic Plague In Fourteenth Century Through Eighteenth Century Europe, Gillian R. Fowler
Moving The Plague: The Movement Of People And The Spread Of Bubonic Plague In Fourteenth Century Through Eighteenth Century Europe, Gillian R. Fowler
Honors Theses
Research regarding the Yersinia Pestis (bubonic plague) in later medieval and early modern Europe has focused mainly on rat fleas and their role in transmitting the bacteria. This research focuses on people and their day to day movements and how that relates to the spread of bubonic plague across the following three areas of Europe, England, France and northern Italy during the time period between the fourteenth and eighteenth centuries. The changing belief system regarding the cause of these outbreaks emerges within these medieval Europeans which helps to facilitate the growing response to plague outbreaks and the affirmative actions taken …
The Uptake And Incorporation Of Exogenous Fatty Acids Confer Phenotypic Advantages To Acinetobacter Baumannii, Saba A. Munir
The Uptake And Incorporation Of Exogenous Fatty Acids Confer Phenotypic Advantages To Acinetobacter Baumannii, Saba A. Munir
Honors Theses
AIM: Acinetobacter baumannii is a ubiquitous gram-negative bacterium found on a variety of surfaces that include skin, hair, and soil. Some gram-negative bacteria like A. baumannii have the ability to acquire and incorporate fatty acids into their phospholipid membranes. Known as ‘Iraqibacter,’ A. baumannii has emerged as a significant cause of nosocomial infections in the United States and abroad. This study was designed to determine whether structural alterations occur in A. baumannii upon exposure to a wide range of polyunsaturated fatty acids (PUFAs) as well as the significance of this phenomenon in terms of survival and resistance to stress. Thin …
A Comparison Of Cyfra 21-1, Nse, And Cea For The Serodiagnosis Of Lung Cancer, A Alexandra Knopp
A Comparison Of Cyfra 21-1, Nse, And Cea For The Serodiagnosis Of Lung Cancer, A Alexandra Knopp
Honors Theses
There were 224,210 new cases of lung cancer in the US during 2014, and of those cases, there 159,260 that died from lung cancer during 2014. Since early diagnosis and treatment leads to a better prognosis, the medical community is actively looking for new, noninvasive tests for the disease. This includes the search for new and effective tumor markers. Tumor markers are used in combination with other tests to diagnose cancer. After the diagnosis, they are used to follow a patient’s case. The three tumor markers studied were neuron specific enolase (NSE), carcinoembryonic antigen (CEA), and CYFRA 21-1. In this …
Access To Healthcare: Understanding Disparities Among Lgbt & Black Communities, Taylor Jones
Access To Healthcare: Understanding Disparities Among Lgbt & Black Communities, Taylor Jones
Honors Theses
This paper aims to explain and improve the disparities that intersect the Black and LGBT communities of Berrien County as it relates to access to healthcare, specifically those at risk for HIV. This paper identifies the various resources used to highlight these including the Kalamazoo Community AIDS Resource Education Services (CARES). There are many factors that put these populations at risk. The LGBT and Black communities are at risk due to factors such as STIs, multiple sex partners, unprotected sex, use of drugs during sex, low socioeconomic status, inadequate data on race, ethnicity, and language lowers the likelihood of effective …
Effects Of Synthetic Blood Plasma On Calcium Dependent Dimerization Of Ncad12, Brent Treadway
Effects Of Synthetic Blood Plasma On Calcium Dependent Dimerization Of Ncad12, Brent Treadway
Honors Theses
Neural Cadherin (NCAD) is one of three Type 1 vertebral classical cadherins that function as the primary transmembrane component in cell-to-cell interactions at adherens junctions. Adhesive interactions mediated by this protein are calcium dependent with three calcium-binding sites between each of its five extracellular domains. NCAD is very important in many cell-to-cell interactions because of its function in development and in immune and neurological synapses. Generally, in vitro studies of calcium dependent dimerization of NCAD are conducted in a nonphysiological buffer (NaCl + HEPES: SEC buffer). In order to study dimerization in more physiologically relevant conditions, I created a synthetic …
Variations In Microbiota Of Culex (Melanoconion) Ocossa And Culex (Culex) Declarator Across Peri-Urban And Rural Environments, M. Nelson Starkey
Variations In Microbiota Of Culex (Melanoconion) Ocossa And Culex (Culex) Declarator Across Peri-Urban And Rural Environments, M. Nelson Starkey
Honors Theses
Mosquitoes serve as the primary mode of transmission for many tropical infections such as Venezuelan equine encephalitis virus, dengue virus, and malaria. Therefore, mosquitoes are an important area of study for disease control. This study is part of a larger goal to examine the differences in gut microbiota of Culex melanoconion species across two different habitats: periuban and rural. Mosquitoes were collected from locations around Iquitos, Peru and their gut bacterial DNA was extracted and analyzed. Based on previous studies, it is believed that the bacterial flora will differ among mosquitoes reared in different locations.
Regime Type And Healthcare Systems: A Global Quantitative Analysis, R. L. Barr
Regime Type And Healthcare Systems: A Global Quantitative Analysis, R. L. Barr
Honors Theses
This thesis examines the link between regime type and healthcare systems. After reviewing literature that examines regime type, social spending, and healthcare, as well as a more specific example of regime change in Chile, it undertakes a multivariate regression analysis of 183 countries. It concludes that democracies have significantly better healthcare-system indicators, but that environmental variables, such as Latitude and Percentage of Rural Population, are more significant predictors of healthcare. It concludes that, while regime type is an important factor, dealing with ecological and locational problems of a country, such as combating tropical diseases and expanding access to infrastructure, are …
Discovery Of Resistance-Reversing Agents In Antibiotic Resistant Strains Of Escherichia Coli And Klebsiella Pneumoniae From Natural Product Libraries, Andrew B. Watkins
Discovery Of Resistance-Reversing Agents In Antibiotic Resistant Strains Of Escherichia Coli And Klebsiella Pneumoniae From Natural Product Libraries, Andrew B. Watkins
Honors Theses
Objective: The objective of this exploratory research is to discover compounds, particularly from natural products, that inhibit ESBL, KPC, and NDM-1 mechanisms of antibiotic resistance in the Gram negative bacteria Escherichia coli and Klebsiella pneumoniae. Methods: This objective will be accomplished utilizing a high-volume bioassay testing natural product samples from the National Center for Natural Products Research. This assay tests samples against 6 different strains of bacteria known to express β-lactamases in the presence and absence of sub-inhibitory concentrations of the test antibiotic. By structuring the assay in this way, differentiation may be made between the inherent antibacterial activity of …