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Articles 181 - 210 of 330
Full-Text Articles in Entire DC Network
The Underlying Determinants And Impacts Of The Substance Abuse Crisis In Knox, Whitley, And Laurel Counties, Mikaela B. Rhodes
The Underlying Determinants And Impacts Of The Substance Abuse Crisis In Knox, Whitley, And Laurel Counties, Mikaela B. Rhodes
Honors Theses
Substance use has become a growing problem on a national, statewide, and local level. While the commonwealth of Kentucky has astonishing rates of substance use and abuse, the areas of Knox, Whitley, and Laurel counties of Kentucky are observing similar results within county lines. There are many social determinants that could potentially lead an individual to substance use or abuse which can often be unique to an area as well as the adverse effects of substance abuse on a community. Interviews were conducted with individuals in professions that directly relate to the substance abuse crisis in Knox, Whitley, and Laurel …
How Non-Centrist Parties Gain Electoral Success In German Politics: An Analysis Of The Alternative Für Deutschland’S Success In The 2017 Federal Election., Madison B. Bickert
How Non-Centrist Parties Gain Electoral Success In German Politics: An Analysis Of The Alternative Für Deutschland’S Success In The 2017 Federal Election., Madison B. Bickert
Honors Theses
[No Abstract was provided]
Contagious Or Not Contagious: Is That The Question? Evaluating The Effects Of Disease Contagion On Memory For Word Lists, Laura Pazos
Honors Theses
Researchers have suggested that individuals possess a disease-avoidance system designed to detect and remember potential sources of harmful pathogens, a system termed the behavioral immune system. Recently, Fernandes, Pandeirada, Soares, and Nairne (2017) reported an increase in memory for objects associated with individuals that are contaminated with a disease. My thesis extends this finding by examining whether disease-related memory benefits are due to the mere presence of a disease or whether the disease needs to be perceived as contagious and thereby threatening to facilitate memory. Two experiments, one between- and one within-subjects, were designed to test memory performance in the …
Age-Related Tick Infestation Patterns In Springtime Migratory Passerines, Matthew Dunning
Age-Related Tick Infestation Patterns In Springtime Migratory Passerines, Matthew Dunning
Honors Theses
To test the hypothesis that younger migrants are more prone to arrive at stopover sites on the northern coast of the Gulf of Mexico with ticks than adult migrants, 2177 migratory passerines were screened for ticks at Gulf Coast sites in Texas and Louisiana. Fifty eight (2.7%) were infested with ticks with 28 (1.3%) being young birds and 30 (1.4%) being adult birds. The body condition of the birds was assessed to determine if tick infestation had negative consequences and if the severity of consequences varied between ages. I found no relationship of age with the prevalence of a tick …
The Dna Damage Response Gene Ddr48 Regulates Sterol Synthesis Genes To Confer Antifungal Resistance To The Pathogenic Fungus Histoplasma Capsulatum, Gabriella Reyes
The Dna Damage Response Gene Ddr48 Regulates Sterol Synthesis Genes To Confer Antifungal Resistance To The Pathogenic Fungus Histoplasma Capsulatum, Gabriella Reyes
Honors Theses
Histoplasma capsulatum is a dimorphic fungal pathogen that is endemic to the Ohio, Missouri, and Mississippi river valley regions. The fungus grows as a mold at environmental temperatures (25C) and transforms into a unicellular yeast upon inhalation by a mammalian host (37C). The mold to yeast shift is required for pathogenicity in host organisms, where the potentially fatal disease, histoplasmosis, can present. This study aims to characterize the DNA damage response protein DDR48 and the role that it plays in combating cellular stressors in H. capsulatum. We found that DDR48 is expressed strongly in the mold phase but expressed only …
Influence Of Environmental Conditions On Fatty Acid-Induced Changes In Vibrio Cholerae Persistence And Pathogenicity, Abigail Doyle
Influence Of Environmental Conditions On Fatty Acid-Induced Changes In Vibrio Cholerae Persistence And Pathogenicity, Abigail Doyle
Honors Theses
Vibrio cholerae, a Gram-negative bacterium, is responsible for the acute intestinal infection known as cholera. This illness is due in part to V. cholerae’s ability to sense and adapt to changing environments as it is ingested into the human body from brackish environments. It was shown in recent studies that this bacteria has the ability to uptake exogenous fatty acids, resulting in changes to V. cholerae persistence and pathogenicity. The aim of this research is to determine the extent to which these additional exogenous UFAs influence the persistence and pathogenicity of V. cholerae throughout its transitional period from brackish environments …
Propionate Enhances The Antimicrobial Defenses In Macrophages Against Listeria Monocytogenes, John Weis
Propionate Enhances The Antimicrobial Defenses In Macrophages Against Listeria Monocytogenes, John Weis
Honors Theses
Propionate is a short chain fatty acid produced by the bacteria in the human gut. It has a wide range of nutritional functions in the human body. Several studies have also reported the effects of propionate on immune cell activation. In this study, we used Listeria monocytogenes as a model pathogen to determine how and what the effects of propionate on immune cells influence cell susceptibility to infections. Listeria is a dangerous intracellular pathogen that can replicate inside immune cells such as macrophages. Therefore, we can assess the impact of propionate on infection susceptibility by performing cell culture infections. We …
Character And Water Quality Of Sandpiper Pond: A Coastal Pond Assessment, Fifteen Years After Restoration, Nicholas E. Workman
Character And Water Quality Of Sandpiper Pond: A Coastal Pond Assessment, Fifteen Years After Restoration, Nicholas E. Workman
Honors Theses
Sandpiper Pond is a coastal pond at Huntington Beach State Park, South Carolina. Originally a tidal inlet surrounded by marshland, it was isolated in 1989 and rechanneled in 2004-2005 under a community-based wetland restoration project. The project was designed to restore the pond to a tidal inlet to improve water quality and biodiversity. Since then, the tidal connection with the ocean has been severed once more and the main influx of seawater occurs from the marsh during spring high tides. In this three-month study, the current state of Sandpiper Pond is evaluated using fundamental biogeochemical indicators that are indicative of …
Pathogenic Differences In Listeria Monocytogenes 10403s And Cardiotropic Strains Grown Under Aerobic And Anaerobic Conditions, Alexander Hayes
Pathogenic Differences In Listeria Monocytogenes 10403s And Cardiotropic Strains Grown Under Aerobic And Anaerobic Conditions, Alexander Hayes
Honors Theses
Listeria monocytogenes is a gram-positive bacillus that is commonly associated with foodborne illness. It is a facultative intracellular pathogen responsible for causing the listeriosis infection in humans which is particularly dangerous to immunocompromised individuals. L. monocytogenes pathogenesis occurs through a series of complex interactions between host and bacterial cellular machinery. The wild-type strain as well as a cardiotropic strain with high affinity for infecting cardiac tissue were used to investigate pathogenesis in L. monocytogenes. Specifically, the Listeriolysin O protein that is critical for virulence was investigated. Aerobic and anaerobic growth environments as well as short-chain fatty acid supplementation were utilized …
Analysis And Review Of The Effects Of Bacterial Competition On Efflux Pump Inhibition, Robert Leszcynski
Analysis And Review Of The Effects Of Bacterial Competition On Efflux Pump Inhibition, Robert Leszcynski
Honors Theses
Multidrug resistant antibacterial strains are a dangerous problem for modern medical professionals. When cells of two different strains are grown together, they must compete with each other for nutrients. This competition can lead to the production of harmful compounds that are toxic to the competing strain. One such compound may be a compound that inhibits the efflux of antibiotics from the cell. When the cells compete with one another, one or both of the cells will produce compounds that are harmful to the competing strain.
Establishing The Effect Of Ethanol On Listeria Infection, Ryan Evan Restrepo
Establishing The Effect Of Ethanol On Listeria Infection, Ryan Evan Restrepo
Honors Theses
Excessive alcohol consumption is common in the United States, particularly among college campuses. Previous studies have shown that excessive drinking increases the risk of drug dependency, sexual assault and liver damage. Heavy drinking has also proven to impact immune capabilities. Immune cell function and numbers have been shown to be negatively impacted by alcohol treatment. This research project used different cell cultures to model human cells and investigated how exposure to alcohol affects susceptibility to bacterial infection. Listeria monocytogenes, a common foodborne bacterium, was used as a model pathogen. A high alcohol preferring mouse model was also used to examine …
Predator Diet Affects Perceived Oviposition Site Quality For Mosquitoes, Brandon Mcdaniel
Predator Diet Affects Perceived Oviposition Site Quality For Mosquitoes, Brandon Mcdaniel
Honors Theses
Ovipositing freshwater organisms rely primarily on cues to determine site quality (Silberbush and Blaustein 2008) and to select an ideal habitat for their offspring (Resetarits 2014). Characteristics of high quality oviposition sites that yield the greatest fitness for offspring include the absence of predators and high resource availability that allows for optimal growth and development (Kershenbaum et al. 2012). It has been shown that predator presence is a large deterrent of oviposition due to threats of offspring survival, however, there is a little information about the predatory cues mosquitoes experience before ovipositing (Angelon and Petranka 2002). One hypothesis is that …
Microbial Communities Associated With Dragonfly Nymphs Raised In Varying Concentrations Of Amoxicillin, Michelle Basha
Microbial Communities Associated With Dragonfly Nymphs Raised In Varying Concentrations Of Amoxicillin, Michelle Basha
Honors Theses
The bacteria on and within an organism make up that organism’s microbiome. Given interest in the use of antibiotics in agriculture and the effect of microbes on human health, more studies are needed on the microbial community composition of different organisms and how it responds to antibiotic use. This study investigated changes in the amount of antibiotic resistant bacteria present in dragonfly nymphs exposed to differing concentrations of amoxicillin. Next generation sequencing of the 16S rRNA gene was used to identify cultures of these antibiotic resistant bacteria. Increasing the concentration of antibiotics the dragonfly nymphs were exposed to resulted in …
Examining The Impact Of Meaning And Resilience On Survivors' Life Satisfaction After Hurricane Harvey, Emily A. Gawlik
Examining The Impact Of Meaning And Resilience On Survivors' Life Satisfaction After Hurricane Harvey, Emily A. Gawlik
Honors Theses
The experience of a traumatic event such as a natural disaster can often lead individuals to suffer a variety of negative sequelae, including the development of posttraumatic stress symptoms. However, certain positive psychological constructs like meaning and resilience have been shown to mitigate these consequences. The purpose of this study was to explore the contributions of meaning and resilience to the life satisfaction of individuals (N = 55) impacted by 2017’s Hurricane Harvey. It was hypothesized that not only would meaning and resilience be significantly and positively related to life satisfaction but that meaning would contribute more to the prediction …
Effects Of Vertical Transmission Of Maternal Antibodies To Mycoplasma Gallisepticum On Growth And Condition Of Eastern Bluebird Nestlings (Sialia Sialis), Mckenzie Xiang Denton
Effects Of Vertical Transmission Of Maternal Antibodies To Mycoplasma Gallisepticum On Growth And Condition Of Eastern Bluebird Nestlings (Sialia Sialis), Mckenzie Xiang Denton
Honors Theses
Mothers display maternal effects to influence the development and success of offspring through processes such as resource allocation. In birds, this occurs largely through the egg yolk with the vertical transmission of antibodies to offspring to protect the vulnerable young from disease. Specifically, poultry and eastern bluebirds across the eastern United States are commonly infected by the bacteria Mycoplasma gallisepticum (MG), for which mothers may produce antibodies against. To test for the vertical transmission of MG-specific antibodies from mothers to nestlings in eastern bluebirds and the associated fitness effects, bluebird boxes were set up and monitored during the field season. …
State And Regional Comparisons Of Breastfeeding Policies And Rates: A National Study, Erin Johnson
State And Regional Comparisons Of Breastfeeding Policies And Rates: A National Study, Erin Johnson
Honors Theses
State legislation focused on promoting and supporting breastfeeding is relatively new, beginning in the 1990s. The purpose of this study is to determine if there is an association between state breastfeeding rates and state breastfeeding legislation and other institutional policies. The Centers for Disease Control and Prevention releases breastfeeding report cards with the most up-to-date state breastfeeding rates. These reports are used to examine the relationship between state breastfeeding rates and number of breastfeeding policies passed by a state. Government initiatives, such as Healthy People Initiative, and organizational practices, such as Baby-Friendly USA Inc., are also studied to determine their …
Evaluation Of The Efficacy Of A Recombinant Simian Varicella Virus Vaccine Expressing Simian Immunodeficiency Virus Envelope And Capsid Proteins, Thomas G. Wichman
Evaluation Of The Efficacy Of A Recombinant Simian Varicella Virus Vaccine Expressing Simian Immunodeficiency Virus Envelope And Capsid Proteins, Thomas G. Wichman
Honors Theses
Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T-lymphocytes, which when left untreated, later develops into Acquired Immunodeficiency Syndrome (AIDS). Up to 25,000 people die every week from AIDS infection, making HIV and AIDS research a very high priority for virologists. While highly researched by scholars around the world, no person has been able to develop a successful vaccine, as the retroviral nature of the virus and its high mutation rate make vaccine development incredibly difficult. However, recombinant genetic technology will hopefully allow the revolutionization of vaccines which have already proven effective in immunization. The already developed varicella-zoster …
Hit Me With Your Best Shot: A Critical Analysis Of The Resistance To Vaccine Utilization, Katherine Coleman Sistrunk
Hit Me With Your Best Shot: A Critical Analysis Of The Resistance To Vaccine Utilization, Katherine Coleman Sistrunk
Honors Theses
Vaccines have provided humans protection from infectious diseases for centuries, yet the vaccination rate in the United States fails to come near one-hundred percent, allowing vaccine-preventable diseases to re-emerge in communities across the nation. Vaccines have proven to be a safe and effective method in preventing the spread of infectious disease, but vaccine resistance remains high due to false information perpetuated by anti-vaxxers, greatly impacting the vaccination rate in our country. This thesis, by means of a literature review, provides a critical analysis the resistance to vaccine utilization in the United States to determine what policy recommendations and interventions can …
The Protective Role Of Estrogen On Hiv-1 Mediated Neurotoxicity, Macklin Licamied
The Protective Role Of Estrogen On Hiv-1 Mediated Neurotoxicity, Macklin Licamied
Honors Theses
The prevalence of HIV among men have been in a steady inclination over the last several decades, yet the accelerated infection rate among older women is considerably concerning. Not only does the HIV virus affect the immune system but it also affects the central nervous system. One of its viral proteins, Tat, acts as an excitotoxin and disrupts the cell’s membrane potential by increasing the concentration of Ca2+ inside the cell. This influx of calcium ions leads to apoptosis and secretion of the cell’s contents into the surrounding area. Macrophages, along with other innate immune components, gather and induce the …
Drawing The Line: Ancient Hominins And The Species Question, Erin Hurley, Carolyn Dillian
Drawing The Line: Ancient Hominins And The Species Question, Erin Hurley, Carolyn Dillian
Honors Theses
he present paper asserts that groups such as Neandertals and Denisovans should be considered subspecies of H. sapiens. This contention is based upon the biological species concept and the fact that these groups interbred to create viable offspring. It is also stated that introgression from these groups made several positive contributions to the evolution of H. sapiens and their genome that may have served to promote the persistence of H. sapiens in Eurasia.
Vertical Transmission Of Zika Virus In Aedes Aegypti And Aedes Albopictus, Stephanie Cantu
Vertical Transmission Of Zika Virus In Aedes Aegypti And Aedes Albopictus, Stephanie Cantu
Honors Theses
Arboviruses such as Zika (ZIKV), dengue, chikungunya are responsible causing over 4 million people to live with debilitating conditions and may produce long-term health consequences. Zika virus, a newly emerging arbovirus, has potentially severe neurological complications and a potential to cause severe birth defects. There are no current vaccines for Zika virus, and the primary method for control the spread of this disease is through early detection and vector control. Assessing and quantifying viral transmission patterns is critical for successful control efforts. Zika virus shows some unique (among arboviruses) transmission patterns, notably the ability to be sexually transmitted. One aspect …
Evaluation Of A Natural Challenge Model Of Zebrafish With Influenza A Virus, Kelvin Blade
Evaluation Of A Natural Challenge Model Of Zebrafish With Influenza A Virus, Kelvin Blade
Honors Theses
Influenza A virus (IAV) presents as a global public health concern, resulting in an extensive burden on morbidity and mortality rates in humans. IAV has high mutation rates, influencing emergence of new virus strains, which could lead to increased antiviral resistivity and altered virulence. Although prevention and treatment of influenza infections have been improved, animal models still play a major role in understanding of host responses and the pathogenesis of IAV infection. Zebrafish are useful host models for evaluating infectious diseases processes, especially with the ability to manipulate the genome of zebrafish. Research by others have shown that parenteral applied …
An In Vitro Analysis Of The Relative Efficacies Of Antibiotic Solutions Vs. Antiseptics In Breast Augmentation And Reconstruction Surgery, Victoria Noyes
An In Vitro Analysis Of The Relative Efficacies Of Antibiotic Solutions Vs. Antiseptics In Breast Augmentation And Reconstruction Surgery, Victoria Noyes
Honors Theses
Breast augmentation and reconstruction procedures are among the most popular plastic surgeries in the U.S. Opportunistic bacterial pathogens introduced during surgery can lead to surgical site infections, capsular contractures, biofilm formation, and lymphoma. To prevent these infections, an antibiotic solution containing Cefazolin, Gentamicin, and Bacitracin (Adams’ Antibiotic Solution - AS) has traditionally been used for irrigation. Due to antibiotic resistant pathogens and a debate over the efficacy of irrigation by AS to reduce infections, alternatives must be found. This study considers the use of the antiseptic chlorhexidine gluconate (CHG) as an alternative irrigation solution. In vitro, we exposed pure cultures …
Increasing Awareness Of International Adoption Through Literature, Romy Newberry
Increasing Awareness Of International Adoption Through Literature, Romy Newberry
Honors Theses
No abstract provided.
Molecular Monitoring Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) In A Hospital Setting, Jessica Ammon
Molecular Monitoring Of Methicillin-Resistant Staphylococcus Aureus (Mrsa) In A Hospital Setting, Jessica Ammon
Honors Theses
Methicillin resistant Staphylococcus aureus (MRSA) is a potentially pathogenic bacterium that poses a serious risk in healthcare settings. MRSA can be characterized by a genetic element, known as the staphylococcal cassette chromosome, which harbors the gene responsible for methicillin resistance, mecA. MRSA can be classified into two categories: community acquired (CA) and hospital acquired (HA). S. aureus strains represent a major health concern due to their prevalence in healthcare facilities and their rapidly evolving antibiotic resistance. The current study investigated the association between MRSA isolates obtained from patients and from the intensive care units in a local hospital. Among the …
Thiol–Ene Photopolymerization: A Simple Route To Pro-Antimicrobial Networks Via Degradable Acetals (Pandas), William Martin
Thiol–Ene Photopolymerization: A Simple Route To Pro-Antimicrobial Networks Via Degradable Acetals (Pandas), William Martin
Honors Theses
The World Health Organization (WHO) has brought the growing epidemic of antibiotic resistance bacteria to the attention of the public and has expressed the need for the development of new methods of defense. In this direction, bioactive aldehyde essential oils have been shown to effectively act as antibiotic and antifungal agents. These bioactive compounds, when used in their pure form, are volatile and lack environmental stability. In this thesis, we describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) using thiol-ene photopolymerization. PANDAs were used as a new model for the high loading and release of bioactive aldehyde-containing compounds …
The Subcloning And Expression Of Munc18a In Escherichia Coli For Antibody Production And Analysis In Mast Cell Degranulation Reactions, Brandi Goble
Honors Theses
Mast cells are secretory cells responsible for fighting off infection through the early recognition of pathogens. This process is completed through the secretion of proinflammatory mediators that are stored in secretory granules within the cytoplasm of the cell. The degranulation secretion process relies on regulated fusion of secretory granules to the cell membrane via membrane-bound SNARE proteins that bridges the two opposed membranes. The intricate regulation of SNARE-mediated mast cell degranulation is not well understood. However, Sec1/Munc18 (SM) proteins, specifically the Munc18 isoforms, are known to play a critical role in the process (Brochetta, et. al., 2014). The Xu lab …
Disruption Of Rna Metabolism By Zika Virus, Maggie Lea Dickerson
Disruption Of Rna Metabolism By Zika Virus, Maggie Lea Dickerson
Honors Theses
Flaviviruses are positive, single-stranded, enveloped RNA viruses that are a part of the family, Flaviviridae. West Nile virus, Dengue, Zika virus and more are a part of this family. Mosquitoes are the vectors for these viruses. In order for the virus to infect mosquitoes, it must evade the RNA interference (RNAi), which is the major antiviral immune mechanism of insects. One study found the 3’ untranslated region (UTR) of the West Nile virus that inhibited the RNAi (GP et al. 2016). The goal of this study is to investigate if the 3’ and 5’ UTR region of the Zika virus …
Vaccine Refusal Dilemmas, Yessica Garcia
Vaccine Refusal Dilemmas, Yessica Garcia
Honors Theses
The topic of the thesis is vaccine refusal dilemmas. The focus is on the current issue of the decreasing immunization rates in children. Children are a vulnerable population and rely on their parents to make healthcare decisions for them. This thesis will address the parents’ standpoint on immunizations, the providers’ standpoint on the situation, and the sources of vaccination information available, then determine vaccine refusal dilemmas that may result. The main population of focus will be pediatric patients including their families and their providers. Dilemmas associated with vaccine refusal and/or hesitancy will include present and existing issues as well as …
The Influence Of Self-Enhancement And Stress On Weight Gain: A Biopsychosocial Approach, Olivia G. Grondalski
The Influence Of Self-Enhancement And Stress On Weight Gain: A Biopsychosocial Approach, Olivia G. Grondalski
Honors Theses
The current longitudinal study was conducted to test if people perceive their physical body size to be smaller than it is, and if people do self-enhance their body size, then how do body self-enhancement and stress interact to predict subsequent Body Mass Index (BMI). This study toke a biopsychosocial approach to understanding why people make health decisions by measuring participants’ self-enhancement, perceived stress, cortisol baseline levels, and stress reactivity and observing their associations and interactions with subsequent weight gain. Self-enhancement is a type of positive illusion characterized by overly positive attitudes people have towards themselves, which is used for promotion …