Digital Commons Network^™

Evolutionary Genomics Of Dynamic Sex Chromosomes In The Salicaceae, Ran Zhou

Graduate Theses, Dissertations, and Problem Reports (ETD)

Identifying the sex-determination region (SDR) and other genomic features of sex chromosomes are of great importance in the studies of the evolution of sex. However, the process of accurately identifying the size and location of the SDR is often difficult, even when a genomic sequence is available. This usually is hindered by large repetitive elements and a lack of recombination in the SDR. In this thesis, I assemble sex chromosomes with whole genomic sequencing data, identify SDRs and explore their genomic features in two sister species from the Salicaceae family. I also develop an interpretation of the lability of the …

Neuroimaging Of Real-World Audio-Visual Sensory Integration In High-Functioning Autism, Paula J. Webster

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sensory processing differences are a prevalent aspect of autism spectrum disorder (ASD) that may contribute to core deficits of ASD such as repetitive behaviors as well as comorbidities including anxiety disorders. The ability to integrate information among our senses is required to comprehend the world around us and is crucial for the development of language, motor skills, and social communication. Prior studies have shown that individuals with autism differ from individuals without autism when presented with simple, non-natural audio-visual stimuli such as basic shapes accompanied by pure tones. Because the human brain processes non-natural and natural stimuli differently, more recent …

Interpretations Of Bicoherence In Space & Lab Plasma Dynamics, Gregory Allen Riggs

Graduate Theses, Dissertations, and Problem Reports (ETD)

The application of bicoherence analysis to plasma research, particularly in non-linear, coupled-wave regimes, has thus far been significantly belied by poor resolution in time, and/or outright destruction of frequency information. Though the typical power spectrum cloaks the phase-coherency between frequencies, Fourier transforms of higher-order convolutions provide an n-dimensional spectrum which is adept at elucidating n-wave phase coherence. As such, this investigation focuses on the utility of the normalized bispectrum for detection of wave-wave coupling in general, with emphasis on distinct implications within the scope of non-linear plasma physics. Interpretations of bicoherent features are given for time series from …

A Survey Of Selected Classical Chinese Art Songs For Solo Voice And Piano From 1920 To 1950, Tingting Chang

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study aims to provide a repertoire guide of Chinese art songs for the pedagogical and research needs of musicians and scholars. Chinese art songs are derived from Western art songs. This work provides a valuable resource outside the scope of the standard art song repertoire. There are very limited studies with annotated lists of Chinese art song repertoire in English. Therefore, it is difficult for teachers to search for specific Chinese art songs to utilize with students who have different voice types and learning levels. This study will provide a practical tool that will meet these pedagogical needs.

All …

Oxygen Transport Kinetics Of Surface Modified Mixed Conductor (La0.60sr0.40)0.95co0.20fe0.80o3-X As Solid Oxide Fuel Cell Cathode, Manuel Serrano Laguna

Graduate Theses, Dissertations, and Problem Reports (ETD)

The oxygen transport kinetics of the electrodes of Solid Oxide Fuel Cells (SOFC) are critical properties to achieve higher efficiencies in the cell. (La0.60Sr0.40)0.95Co0.20Fe0.80O3-x (LSCF) is a mixed ion-electron conductor material that is expected to be optimized and utilized as the cathode of the SOFC’s. The reason for LSCF to be considered as the next cathode material for SOFC is due to its high ionic and electronic conductivities, and high oxygen transport kinetics. Additionally, to the excellent properties that this material offers, it has been seen that the kinetic properties of the material can be further optimized by adding a …

Behavioral Functions Of Stimuli Correlated With Transitions Between Rich And Lean Schedules Of Reinforcement, Cory Whirtley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Disruptions in operant behavior in the form of extended pausing reliably occur when there is a discriminable transition from a relatively rich schedule of reinforcement to a relatively lean schedule (i.e., a rich-lean transition). The present experiments assessed the reinforcing and aversive functions of the stimuli correlated with the transitions between rich and lean schedules using observing and escape procedures. In both experiments, pigeons’ key pecks were reinforced with food on a compound schedule with two FR components. Completing the FR in the rich component produced a large reinforcer; completing the FR in the lean component produced a small reinforcer. …

The Effects Of Internal Physiology On Polyphenic Horn Development In The Dung Beetle Onthophagus Taurus, Naomi Garrett Williamson

Graduate Theses, Dissertations, and Problem Reports (ETD)

An organism’s phenotype can be affected in development by alterations to gene expression based on environmental inputs. Nutrition is one such environmental input and the central regulator of development of large horn or small horn phenotypes in the dung beetle species, Onthophagus taurus. However, little is known about the nature of chemical compounds that are critical to this plastic horn development. To better understand these compounds, we are utilizing an untargeted metabolomic approach as well as a targeted gene approach. Through the metabolomic approach, it was uncovered that environmental conditions tend to have a greater impact on metabolomic composition …

Top-Down Model Development Using Data Generated From A Complex Numerical Reservoir Simulation With Water Injection, Yvon Andrea Martinez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Numerical simulation and data-driven modeling are two current approaches in engineering reservoir modeling. Numerical reservoir simulation attempts to match past production history by modifying reservoir properties of the model. After multiple computationally intensive trial and error efforts, accurate history matches are identified. These history matches are used by project management for production forecasting purposes. Data-driven reservoir modeling utilizes measured data and is, therefore, free of assumptions that are often included in numerical reservoir simulations. Artificial intelligence and machine learning algorithms are technologies implemented in the development of a data-driven reservoir model with efforts to learn fluid flow through porous media …

Evaluating Inorganic Feed Phosphate Type And Further Potential Of Phytase Supplementation Using A Commercial Broiler Model, Angela Elsie Lamp

Graduate Theses, Dissertations, and Problem Reports (ETD)

Optimizing feed formulation of poultry diets may be achieved by proper utilization of nutrients and feed additives. This will provide a less expensive and nutrient efficient diet to the bird. An experiment was conducted to evaluate early broiler performance, tibia mineralization, and mineral digestibility of broilers fed diets that differed in inorganic feed phosphates (IFP) but that were formulated to be either similar in dietary non-phytate phosphorus (nPP) and calcium to phosphorus ratio (Ca:P), total mineral content, or calculated prececal digestible phosphorus (CPDP). Dicalcium phosphate (DCP), monodicalcium phosphate (MDP), monocalcium phosphate (MCP), and defluorinated phosphate were used in formulations with …

Changing Dynamics Of Opioid Overdoses In West Virginia And Impact Of Medication For Opioid Use Disorder And Recurrence Of Overdose On Reducing Mortality Among West Virginia Medicaid Beneficiaries, Zheng Dai

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background

With increasing number of opioid overdoses in West Virginia (WV) in recent years and limited number of people receiving treatment, the dissertation study aims to better understand fatal overdose problems in WV and the impact of medication for opioid use disorder (MOUD) in preventing overdose deaths.

Method

WV drug-related deaths from 2005 to 2018 was used to describe the involvement of fentanyl and FAs. WV Medicaid claim data was analyzed to describe the recurrent opioid overdose and the changes in receipt of MOUD. Further, a Medicaid opioid overdose cohort was created to evaluate the effect of occurrence of recurrent …

Voices Of PłaszóW: The Impact Of Schindler's List On A Former Concentration Camp, Jordan L. Riggs

Graduate Theses, Dissertations, and Problem Reports (ETD)

Steven Spielberg’s Schindler’s List drew international attention to the site of Płaszów, a former Nazi concentration camp in Poland near the city of Kraków. This increased attention on the site impacted the area, leading to an increase in film-tourism, shown both in organized tours and published guidebooks. The site and film also held a personal connection to two sets of individuals, the descendants of Nazi commandant Amon Goeth and Holocaust survivors, which often prompted them to return to the site and push for more interpretation. This thesis addresses the lasting impact of the film on the site and the site’s …

Development Of An Activity-Based Windowing Approach To Evaluate Real-World Nox Emissions From Modern Medium And Heavy-Duty Diesel Trucks, Rasik Pondicherry

Graduate Theses, Dissertations, and Problem Reports (ETD)

The introduction of in-use emissions regulations by the United States Environmental Protection Agency (U.S.EPA) requires medium-duty (MD) and heavy-duty (HD) engine manufacturers to demonstrate emissions compliance during in-fleet operation. In the United States (U.S.), the Not-to-Exceed (NTE) method is used to evaluate real-world emissions compliance from on-highway MD and HD trucks. Regulatory agencies, engine manufacturers and research entities have identified that the NTE method incorporates numerous exclusions and evaluates emissions compliance only under selective operating conditions that are favorable for the selective catalytic reduction (SCR) system to reduce oxides of nitrogen (NOx) emissions efficiently. Such operation is typically encountered only …

Shaping Urban Spaces To Fit Into Religious Boundaries Through Landscape, Niharika Alahari

Graduate Theses, Dissertations, and Problem Reports (ETD)

In India, rivers are considered a sacred entity for Hindus and temples on the banks of rivers are a common sight in Indian architectural character. Devotees come to worship and perform small ceremonies on ghats, banks of the river, to the gods and ancestors. This is considered a part of an important ritual prior to entering the temple associated with the river. One such river in South India where this practice occurs, is the Krishna river in Vijayawada, an important pilgrimage center for devotees and the location for this study. Although this practice is a daily occurrence and one hundred …

The Roman Catholic Ordinary Mass From Circa 1750 To Circa 1820: A Selected Bibliography, Letícia Gabriele Grützmann Januario

Graduate Theses, Dissertations, and Problem Reports (ETD)

Orchestrated masses from the 18th century and early years of the 19th century provide a valuable source of repertoire for contemporary choral conductors. This project will explore composers and works from circa 1750 to 1820 to provide choral conductors with a list of works suitable for programming based on the practical size of vocal and instrumental forces.

Western choral music was born in a church setting. Among all choral genres, the mass is the only genre composed throughout all eras, from medieval until the 20th century. The mass remained a prominent genre during the 18th century despite the secularizing influence …

Evaluation Of The Performance Of Probabilistic Genotyping Software On Complex Mixture Samples, Kristen Newland

Graduate Theses, Dissertations, and Problem Reports (ETD)

Probabilistic genotyping systems use sophisticated algorithms to aid DNA analysts with complex mixture interpretation. These systems are used to generate a likelihood ration (LR) which is used to provide the analyst with the statistical weight of the match between an evidence profile and a known contributor. Complex mixtures occur from samples consisting of more than two contributors and samples that have experienced degradation or consist of low template quantity.

This study was performed to compare the performance of three mixture analysis software tools on the same set of samples to determine the capabilities of each software, false inclusions, and false …

Dendroclimatic Analysis And Site Index Modeling Of Central Appalachian Red Spruce, Eric L. Yetter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Red spruce (Picea rubens) was historically an important and dominant timber species in the central Appalachian mountain range. The tree species is now found in a small fraction of its original home range. Threatened and endangered organisms such as the Cheat Mountain Salamander (Plethodon nettingi) rely on red spruce associated forests for survival. Recent concerns including air pollution and climate change may threaten the health of remaining red spruce populations.

I used dendrochronology data to conduct historic dendroclimatic analyses and construct future growth projections for red spruce throughout the central Appalachians. My research involves the use of tree core data …

Comprehensively Improved Electrochemical Performance Of Lithium-Sulfur Batteries By “Chemical Anchors” And Lithium Anode Modification, Zhipeng Zeng

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lithium-sulfur battery is considered to be one of the most promising contenders for the next generation high-energy storages due to their high theoretical energy density (~2600 W h kg^-1). However, a series of issues, especially for the dissolution of lithium polysulfides (LiPSs) with their “shuttle effect” and dendrite formation on the lithium anode, greatly limit their widely commercial applications. Starting from a brief overview of conventional methods to solve these problems, the achievements spotlighted in this research work mainly focus on the structure design of cathode materials by employing “chemical anchors” to effectively suppress the diffusion of LiPSs, …

Associations Between The Adult Adhd Self-Report Rating Scale And The Test Of Differential Inhibition And Attention, Andrew Benton Darling

Graduate Theses, Dissertations, and Problem Reports (ETD)

Attention-Deficit/Hyperactivity Disorder (ADHD) ranks among the most common mental health disorders in adults (APA, 2013). ADHD assessment is complicated by heterogenous symptoms, gender and age differences in diagnosis, variability in symptom manifestation across the lifespan, and comorbidity with other psychiatric disorders and medical conditions (Asherson, 2016; Willcut, 2012; Williamson & Johnston, 2015). The stop-signal task (SST) identifies ADHD clinical groups in children and adults (Lifffijt et al., 2005), yet it remains unclear whether SST performance reflects general deficits in attention (Alderson et al., 2007) or a selective deficit in motor response inhibition (Aron & Poldrack, 2005). Studies of SST often …

Pulmonary Immune Responses To Respirable Elongate Mineral Particles Of Asbestiform And Non-Asbestiform Morphologies, Timur Khaliullin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inhalation exposure to asbestiform elongate mineral particles (EMPs) may cause pulmonary fibrosis, lung and pleural cancer. At the same time, epidemiological evidence for non-asbestiform EMP pathogenicity is scarce, with little if any risk of cancer, but consistent findings of pneumoconiosis and increased mortality. Globally, conditions caused by asbestos exposures contribute most to the occupational cancer burden and are responsible for the increasing mortality for occupational respiratory diseases. Immunological components of the fiber-induced lesions are extremely understudied, partly due to the lack of comparable test articles. In this study I utilized respirable preparations of asbestiform and non-asbestiform riebeckite and tremolite to …

Large-Scale Modeling And Assessments Of Climate, Land Cover, And Sea Level Change Impacts On Stormwater Runoff In Coastal Urban-Natural Environments, Erfanul Huq

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation investigated the potential impacts of changing climate, land cover, and sea level on the future stormwater budget and extreme runoff in coastal urban-natural environments. Two large-scale basins, namely Florida Southeast Coasts Basin (7117 km2) and Saint Johns River Basin (24928 km2), were selected for this study. The basins represented gradients in climate, land cover, and hydrology across the Atlantic coasts of Florida and the southeast U.S. Two mechanistic hydrologic models were developed for the basins using U.S. Environmental Protection Agency (U.S. EPA)’s Storm Water Management Model (SWMM) 5.1. The models were calibrated and validated with observed historical streamflow …

Central Appalachian Understory Red Spruce (Picea Rubens Sarg.) Growth Rates And Allometric Relationships, Joseph M. Gray

Graduate Theses, Dissertations, and Problem Reports (ETD)

Red spruce (Picea rubens) was a prized timber species in West Virginia during the era of resource exploitation in the late 1800s and early 1900s. Consequently, Central Appalachian red spruce has faced large reductions in range and changes in stand composition. This region is relatively underrepresented in literature partially due to these constrictions. Investigating how stem growth occurs in young individuals can fill in some of our gaps in understanding the species and aid in restoration efforts. We sampled an array of high elevation sites on federal and state lands in West Virginia to analyze understory spruce growth …

Development Of Software-Only Simulation Test Beds (Sost) For Spacecraft And Smallsats, Scott Alan Zemerick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Software-only-Simulation Test Beds (SoST) are beginning to become more popular among aircraft, spacecraft, and smallsat embedded system developers due to the high cost of duplicating hardware test beds.

SoSTs provide a software-only, or virtual test bed, that creates a “digital twin” that contains software models of the ETUs and often includes modeled components such as flight computers, busses (e.g., MIL-STD-1553, SPI, I2C), compact PCI (cPCI) backplane cards, sensors, and actuators. The ultimate goal of a SoST is for it to run the native system software compiled-binary on its native CPU architecture (e.g., PowerPC, LEON3/4, ARM) on a standard X86 personal …

The Effects Of Punctuation Events On The Oil Policy Network: A Network Analysis Of Rulemaking Outputs, Fadi M. Mugheirbi

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this dissertation, I display the effect of punctuating events on the oil policy subsystem and network and, in turn, on the rulemaking process. Here I examine whether, and to what extent, the changes in the dynamics of the policy network and the composition of the subsystem caused by the punctuation could alter rulemaking outputs and whether these changes occur simultaneously or sequentially across the policy subsystem and network.

Building upon Punctuation-Equilibrium Theory (PET), Advocacy Coalition Framework (ACF), and the Policy Network Approach (PNA) alongside the political control literature, I provide explanations for the routines and outputs of rulemaking. Accordingly, …

Nitrogen Fertilization Decouples Roots And Microbes In Temperate Forests: Impacts On Soil Carbon And Nitrogen Cycling, Joseph E. Carrara

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the start of the industrial revolution the burning of fossil fuels has resulted in enhanced nitrogen (N) inputs into temperate forests through atmospheric deposition. As N is the limiting nutrient for tree growth across most forests, these inputs have generally enhanced above-ground biomass accumulation. However, the impacts of added N on soil carbon storage (C) are less straightforward. While the mean N response across studies is an enhancement of soil C, these results are variable with some studies reporting net C losses. The classic paradigm posits that N enhances soil C through negative effects on fungal decomposers. However, some …

C-Jun Nh2-Terminal Kinase Signaling Controls Cellular Mechanisms Of Guided Cortical Interneuron Migration, Skye Eleanor Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

The cerebral cortex is an intricately organized brain structure responsible for high-level functions including sensory perception, movement, memory, language, and cognition. During corticogenesis, cortical excitatory neurons and inhibitory interneurons migrate from their respective progenitor zones into the developing cerebral cortex, deposit in the correct cortical layer, and establish connections with their appropriate synaptic partners. The balance between excitation and inhibition is critical for cortical circuitry development and function. Aberrant migration of inhibitory interneurons can alter the formation of cortical circuitry and lead to several neurodevelopmental disorders including epilepsy, autism spectrum disorder, and schizophrenia. Therefore, elucidating the mechanisms responsible for inhibitory …

Obese Zucker Rats As A Reverse Translational Model Of Human Left Ventricular Hypertrophy, Mackenzie Shelby Newman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heart failure is a lifelong disability that for over half of those affected leads to mortality within five years after initial diagnosis. Left ventricular hypertrophy (LVH) is one of the most reliable independent predictors of heart failure. Pathological LVH is irreversible, but early diagnosis is often missed due to its asymptomatic nature. Obese Zucker rats (OZR), which develop obesity due to dysfunctional leptin signaling, naturally exhibit a LVH that mimics the obese human condition. Animal models are necessary because human donor tissue is scarce. The central hypothesis is that genes and proteins that are differentially expressed during development of LVH, …

An Examination Of The Impacts Of The Wvu Research Apprenticeship Program (Rap), Mostafa Hashemi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Finding solutions to the problem of high attrition rates among students has been widely discussed by policymakers. Many intervention programs have been introduced to address this issue. The current study uses the tripartite integration model of social influence (TIMSI), (Kelman 1958, 1961; Estrada et al., 2011) to investigate and evaluate the effects of the research apprenticeship program (RAP), an intervention program aimed at supporting student performance and persistence through research and mentorship implemented at West Virginia University. The mediation analysis revealed research identity as a significant mediator in the relationship between RAP status and STEM persistence. Furthermore, RAP participants were …

Procedure For Asphalt Mixture Friction Evaluation For Wvdoh, Danielle Marie Hoyer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Monitoring asphalt skid resistance in the laboratory could aid in improved friction prediction capabilities and provide insight for developing alternative asphalt mixture designs in the future. The West Virginia Department of Highways (WVDOH) sought the design of a laboratory accelerated asphalt polishing machine to further expand on current skid resistance measurement practices. The design is modeled after the North Carolina State University (NCSU) polishing machine detailed in ASTM E660. The purpose of this research was to develop a testing procedure for the polishing equipment. Friction was monitored with the British Pendulum Tester (BPT) according to ASTM E303.

Specimens were prepared …

Structural Characterization Of Emerging Synthetic Drugs, Jay Tyler Davidson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The identification of well-characterized seized drugs is performed thousands of times a day in the United States; however, the expanding use of emerging synthetic drugs is creating a growing problem for both toxicological and seized drug analyses. Two of the most rapidly growing areas of emerging synthetic drugs are synthetic cathinones and fentanyl-related compounds (FRCs). In this work we demonstrate the combination of multi-stage mass spectrometry (MSⁿ), accurate mass measurements with high-resolution mass spectrometry (HRMS), and isotopic labeling for the structural characterization of synthetic cathinones and fentanyl analogs. The deliverables of this research include the identification of conserved …

Gendered Access To Wetland Gardens (Dimba) In Northern Malawi, Rhoda Nyirenda

Graduate Theses, Dissertations, and Problem Reports (ETD)

Due to increasing degradation of upland fields and in the face of erratic rains and increasing occurrence of droughts and floods and increasing food prices, smallholder farmers in many places across sub Saharan Africa engage in wetland cultivation for livelihoods security (Mutambikwa et al., 2000). A cultivatable wetland area is considered prime land, and a desired opportunity that every rural family need for the purpose of food production. Studies have indicated that wetland cultivation significantly contributes to household’s income and food security. Wetland agriculture, however, in Malawi and most of the sub-Saharan African countries is marred with issues of access …