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Cerebrovascular Dysfunction And Degeneration In Alzheimer’S Disease Pathophysiology, Dominic Dimitri Quintana

Graduate Theses, Dissertations, and Problem Reports (ETD)

Alzheimer’s disease (AD) is a terminal illness and the most common form of dementia, which disproportionately affects the aged population. The pathophysiology of AD is characterized by neurodegeneration that slowly progresses, affecting regions of the brain that are involved in learning, memory, language, and executive function. In patients with the disease, early symptoms include non-disruptive forgetfulness that evolves into the inability to form new memories and ultimately the loss of autonomy at late stages. Histopathological hallmarks in the brain from patients with AD is the presence of amyloid-β (Aβ)-plaques and neurofibrillary tangles (NFT) deposited in the parenchyma. Since the discovery …

Avian And Salamander Response To Young Forest Management In West Virginia, Eric L. Margenau

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation focuses on the effects of various young forest habitat management techniques on the avian and salamander community in West Virginia. Wildlife species associated with the nascent stage of forest succession are experiencing precipitous population declines throughout much of the eastern United States due to decreases in the amount of young forest area which have been brought on by changes in disturbance regimes over the past century. As a result, the need to find novel approaches for creating young forest habitats to sustain young forest wildlife populations is necessary. However, young forest habitat creation often negatively affects species that …

Alluvial Fans, Loess Plains, Lakes, And Distributive Fluvial Systems: Depositional Systems Of The Permian-Triassic Red Beds And Evaporites Of Wyoming (Usa), Jonathan Knapp

Graduate Theses, Dissertations, and Problem Reports (ETD)

The end-Permian ecological crisis was a period of warming and aridity reaching extreme levels by the end Permian and not recovering before the Middle Triassic. The Permian Goose Egg Formation and the Chugwater Group’s Early Triassic Red Peak Formation and Middle Triassic Alcova Limestone are a continuous or nearly continuous succession of rocks deposited during this warm, arid time in Wyoming. Comprised of red beds, evaporites, and rare carbonates, these rocks have not been subjected to detailed sedimentological investigations in the modern era. Previous interpretations of marine and marginal marine deposition have largely been based on the laterally extensive nature …

Solutions To Some Mine Subsidence Research Challenges, Jian Yang

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this work is to address three challenging topics, (1) effects of overburden key strata on subsurface subsidence; (2) effects of longwall subsidence on interstate highways and highway bridges; and (3) effects of dewatering mine water on surface subsidence over inactive room-and-pillar mines, in mine subsidence and to continue improvement of mine safety and health by reducing mine-subsidence related hazards.

Surface and subsurface subsidence events induced by underground mining activities are often capable of causing significant disturbances not only to surface structures, but also to subsurface structures. In this work, models and techniques to study three challenging topics …

"Treading On The Footprints Of History": American Catholic Pilgrimage As Public History, Charlotte Vester

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis, I demonstrate how Catholic pilgrimage is a public history phenomenon. I define public history as public engagement, understanding, and use of the past. While I assert that pilgrimage is a public history phenomenon both in the past and in the present, my thesis will focus on American Catholic pilgrimage at the turn of the twentieth century. Each individual chapter will demonstrate that through pilgrimage, the faithful are engaged in public history in its various forms. Catholics actively took part in past-making and identity-construction in their roles as pilgrims. Through pilgrimage, Catholics were involved in the preservation and …

Design And Development Of A Multi-Nodal Methane Detection System For Longwall Coal Mining, Amber P. Barr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Methane (CH4) explosions pose significant dangers in longwall mining that may lead to injuries and fatalities. Safety is improved through diligent monitoring of CH4 concentration. Currently, regulations require a CH4 monitor be placed on the shearer, downwind of the cutting head. Portable monitor measurements must be taken at various times and locations. If any CH4 monitor measures a concentration greater than 1%, a warning signal must be given. Based on previous research and the location of the CH4 monitor mounted on the shearer (closest monitor to the face), if 1% methane is measured, the concentration at the face may be …

Evaluating The Use Of The M-Vac® Wet Vacuum System To Recover Dna From Cotton Fabric, Phillip Reilly Irion

Graduate Theses, Dissertations, and Problem Reports (ETD)

With the current state of the field of forensic biology, collecting DNA from evidence samples may pose some difficulty. Traditional methods for collection of DNA from biological fluids and touch samples include cuttings, scrapings, and the double swab method. While all of these methods have benefits, they also have their drawbacks. In order to more efficiently collect DNA from an evidence sample, novel approaches need to be explored. This novel approach is the microbial vacuum (M-Vac®) Wet Vacuum System.

This system utilizes a sterile collection solution and a vacuum to collect DNA material from evidence samples. While it is similar …

Effect Of Western Diet And Caloric Substitution With Apple Pomace On Fatty Acid Composition And Gene Expression In The Hypothalamus Of Growing Female Sprague-Dawley Rats, Ayad Abdulhamid Alawadi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The hypothalamus plays a major role in regulating food-intake and energy-expenditure. Hypothalamic dysfunction implicated in neurodegenerative diseases is characterized by diet-induced neuroinflammation and energy dysregulation. Apple pomace, a waste byproduct of processing, is rich in polyphenols and soluble fibers, has the potential to ameliorate diet-inducing inflammation. The objective of this study was to determine the effects of Western diet and caloric substitution of Western diet with 10% apple pomace on brain fatty acid composition and gene expression related to hypothalamic function and health in growing female rats. Growing female Sprague-Dawley rats (age 22-29 days) were randomly assigned (n=8 rats/group) to …

Terrain Aware Traverse Planning For Mars Rovers, Gabrielle Hedrick

Graduate Theses, Dissertations, and Problem Reports (ETD)

NASA is proposing a Mars Sample Return mission, to be completed within one Martian year, that will require enhanced autonomy to perform its duties faster, safer, and more efficiently. With its main purpose being to retrieve samples possibly tens of kilometers away, it will need to drive beyond line-of-sight to get to its target more quickly than any rovers before. This research proposes a new methodology to support a sample return mission and is divided into three compo-nents: map preparation (map of traversability, i.e., ability of a terrain to sustain the traversal of a vehicle), path planning (pre-planning and replanning), …

A Study Of Impact Protection Of Metacarpal Gloves, Faisal Mohammed Alessa

Graduate Theses, Dissertations, and Problem Reports (ETD)

Work-related wrist, hand, and finger injuries are highly prevalent in manufacturing and extractive industries. An analysis of mining-related hand injury data from over the past two decades (Alessa et al., 2020) showed that hand injuries caused by insufficient protection against impact loads (e.g. struck by accidents) were categorized with high severity. Existing literature lacks clear classification and quantification methods for the protection provided by impact-resistant gloves (i.e. metacarpal gloves). A new method to establish a quantitative measure of performance for commonly used metacarpal gloves was developed and evaluated.

In the first specific aim, an experimental study using cadaveric hand specimens …

Spawning Characteristics Of Yellow Perch During Periods Of Water Level Fluctuations In A Hydropower Reservoir, Kyle J. Matt

Graduate Theses, Dissertations, and Problem Reports (ETD)

Water level fluctuations alter reservoir ecosystems causing direct and indirect effects on fish populations. The dewatering of eggs, a direct impact of lake level drawdowns, can affect reproductive success of species that spawn in littoral zones, such as Yellow Perch. I examined relationships between water level fluctuations and spawning characteristics of Yellow Perch in a Central Appalachian hydropower reservoir, where water levels were permitted to be drawn down to 4 m and 2.1 m below the full pool elevation in March and April, respectively. Daily presences of egg masses were recorded on artificial spawning structures at two sites for the …

Protein/Peptide Characterization Using Mass Spectrometry And Molecular Dynamics Simulations, Ahmad Kiani Karanji

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mass spectrometry (MS) based-techniques and molecular dynamics (MD) simulations have been used to characterize protein/peptide structure as well as their interactions with lipid vesicles and detergents. Chapter 1 introduces an introduction to the concepts and tools that were used in this work. In Chapter 2, the dominant gas-phase conformer of [M+3H]3+ ions of the model peptide Acetyl-PSSSSKSSSSKSSSSKSSSSK are examined with ion mobility spectrometry (IMS), gas-phase hydrogen deuterium exchange (HDX), and mass spectrometry (MS) techniques. This section furthers the development of a protein structural prediction tool by providing information about gas-phase ion conformers of two model peptides having different solution conformational …

Palmprint Gender Classification Using Deep Learning Methods, Minou Khayami

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gender identification is an important technique that can improve the performance of authentication systems by reducing searching space and speeding up the matching process. Several biometric traits have been used to ascertain human gender. Among them, the human palmprint possesses several discriminating features such as principal-lines, wrinkles, ridges, and minutiae features and that offer cues for gender identification. The goal of this work is to develop novel deep-learning techniques to determine gender from palmprint images. PolyU and CASIA palmprint databases with 90,000 and 5502 images respectively were used for training and testing purposes in this research. After ROI extraction and …

Fracture Resistance Of Simulated External Cervical Resorption In Anterior Teeth Restored With And Without A Fiber Post., Michelle M. Romeo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: External cervical resorption (ECR) is a destructive type of external resorption that can be difficult to treat. ECR usually begins subgingival at the cementoenamel junction of teeth and continues apically and circumferentially. This substantial loss of tooth structure may make these teeth more prone to fracture and should be addressed when treatment planning teeth with ECR. The aim of this in vitro study was to evaluate the fracture resistance of treated and non-treated teeth with simulated ECR using two different treatment modalities.

Materials and Methods: Forty-eight extracted human permanent mandibular central incisors were selected. Teeth were randomly divided into …

Global Existence And Asymptotic Behavior Of The Solutions To Models For Chemotaxis Systems With Chemo Attractants And Repellents, Aesha Lagha

Graduate Theses, Dissertations, and Problem Reports (ETD)

We study global existence and asymptotic behavior of the solutions to models for chemotaxis systems with chemo attractants and repellents in three dimensions. Chemo attractants and repellents may be called chemo agents. For Part I, we use the logistic model for the mass. The interactions between chemo agents and the mass are taken into account. For Part II, we consider the case when mass is conserved and we use the Lotka-Volterra type model for chemo agents. To accomplish this, we use the Fourier transform and energy method. We show the existence of global solutions by the energy method. Also, we …

The Dark Tetrad, Social Dominance Orientation, And Online Political Discussion, Cory D. Taylor

Graduate Theses, Dissertations, and Problem Reports (ETD)

Previous literature into online trolling behavior has focused upon the role of the Dark Tetrad and political measures separately. This study extended the existing body of research by examining the relationship between the Dark Tetrad personality traits, social dominance orientation (SDO) and online political trolling in the United States of America. The data was collected using an online questionnaire from American users of Facebook and Reddit in the summer of 2020, during the COVID-19 pandemic, Black Lives Matter movement, and in the runup to a hotly contested national election. Positive correlations were found between all of the Dark Tetrad traits, …

Process Modeling And Techno-Economic Analysis Of Thermo-Catalytic Dimethyl Ether Synthesis And Microwave-Based Aromatics Production Technologies From Shale Gas, Chirag Mevawala

Graduate Theses, Dissertations, and Problem Reports (ETD)

Production of dimethyl ether (DME) and direct non-oxidative methane dehydroaromatization (DHA) to aromatics via conventional and microwave (MW)-assisted processes are investigated in this research. Plant-wide models of the shale gas to DME process with integrated CO₂ capture via direct and indirect synthesis routes have been developed. Optimal parameter estimation, and model validation are undertaken for various sections of the process including the pre-reforming reactor, auto-thermal reforming reactor, DME synthesis reactors, CO₂ capture units and separation sections. A novel DME separation process has been developed for efficient separation of DME, syngas, and CO₂. Plant-wide techno-economic optimization is …

Comparison Of The Batch And Individual Log Study Methods For Use In Determining Log Breakeven Pricing, Levi Eric Sisler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding log yields and overrun is critical to a profitable sawmill operation. Lumber yield and overrun data can be gathered through one of two types of sawmill studies: batch studies or individual log studies. Little to no research has previously been conducted to determine if one method provides more reliable results than the other method. For this effort, 16 batch studies were conducted. Individual log studies were also conducted on the same logs, allowing a direct comparison of the results from both study types. A breakeven analysis was conducted for each study type, which determined the amount of variability in …

The Pattern Of Odontogenic Referred Pain, James J. Poulos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Referred odontogenic pain (RP) is a phenomenon that is seen regularly in dentistry and it is not extensively understood. It can make formulating a proper diagnosis difficult and its presence can lead to inappropriate treatment.

Methods: 250 patients experiencing odontogenic pain within the dental clinics of West Virginia University were surveyed. The survey inquired about the patient’s biographical information, medical history, characteristics of the pain, the presence and location of RP, and the psychosocial effects of the pain. Additionally, the endodontic diagnosis of the offending tooth was determined by a member of the endodontic department. The collected …

Development Of New Synthetic Methods For Carbon Nanohoops, Merfat Aljhdli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Carbon nanotubes have received much attention from the material chemists after the synthesis and structure analysis by Iijima in 1991. It was envisioned that cycloparaphenylenes (CPPs), which comprise a sequence of benzene units connected at para position to make a cyclic ring structure, are possible templates for growing carbon nanotubes of a single chirality and single diameter for nanotechnology application. Recently, chemists turned their attention to synthesizing aromatic carbon nanobelts proposed as a general term for carbon molecules composed of fused benzene rings in cylindrical structure shape. Cyclophenacenes (CPAs) as carbon nanobelts are expected to be more suitable candidates for …

Behavior Coaching In Pennsylvania Schools Implementing School-Wide Positive Behavior Interventions And Supports At The Universal Tier One Level, Lisa Anderson

Graduate Theses, Dissertations, and Problem Reports (ETD)

School-Wide Positive Behavior Interventions and Supports (SWPBIS) is a multi-tiered system of student support that emphasizes the use of positive behavior strategies for a school’s students. Schools are adopting SWPBIS because it gives staff the opportunity to teach desired behaviors to students and emphasizes the enhancement of instructional time by minimizing disruptions. SWPBIS uses a support framework that includes a building-level behavior coach and a core team made up of an administrator, parent(s), and professional school staff. Staff and student training is bridged with implementation efforts to sustain a positive school climate and prevent student behavior problems. The SWPBIS coach …

Exploring The Relationship Between Hardiness And Performance In Collegiate Baseball Players, Kevin R. Lou

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to explore the influence of the individual personality characteristic of hardiness on trait anxiety and objective performance within NCAA Division I collegiate baseball players. An updated version of the PVS III-R was used to measure hardiness after a confirmatory factor analysis (CFA) was conducted. Of the total 389 players that participated, 171 met inclusion criteria requirements and were split into two groups – hitters (N=94) and pitchers (N=80) – to identify differences in skills and how sub-constructs of hardiness affected performance through a descriptive correlational prospective design. The results show …

The Effects Of Membrane Physicochemical Properties On Huntingtin Membrane Association And Downstream Aggregation, Maryssa Beasley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by an expanded glutamine repeat region (polyQ) within the huntingtin protein (htt). As a result of the expanded polyQ domain, htt associates into a variety of toxic aggregate species. The polyQ domain of htt is flanked at the N-terminal end by 17 amino acids (Nt17) that adopt an amphipathic α-helical structure in the presence of binding partners such as lipid membranes. In addition to comprising a lipid binding domain, the Nt17 amphipathic α -helix has been directly implicated in htt aggregation initiation via self-association with other Nt17 α -helices. Due to …

The Interplay Of Progestins, Matrix Metalloproteinases, And The Aging Brain, Keyana Nicole Porter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Progestins are synthetic hormones that are designed to mimic the biological actions of progesterone. They, however, possess other pharmacological actions and properties, in addition to their progestational activities. Medroxyprogesterone Acetate (MPA) is a progestin used globally in the hormonal contraceptive, Depo Provera®, by women in their reproductive prime and is a major compound found in hormone therapy (HT) formulations used by menopausal women. MPA is used by approximately 1 in 5 adolescents and adult women in the United States who are sexually active. Globally, nearly 48 million women utilize injectable contraceptives to prevent pregnancy, with most users utilizing MPA as …

Rail-To-Rail Operational In Low-Power Reconfigurable Analog Circuitry, Jared Dale Baker

Graduate Theses, Dissertations, and Problem Reports (ETD)

Analog signal processing (ASP) can be used to decrease energy consumption by several orders of magnitude over completely digital applications. Low-power field programmable analog arrays (FPAA) have been previously used by analog designers to decrease energy consumption. Combining ASP with an FPAA, energy consumption of these systems can be further reduced. For ASP to be most functional, it must achieve rail-to-rail operation to maintain a high dynamic range. This work strives to further reduce power consumption in reconfigurable analog circuitry by presenting a novel data converter that utilizes ASP and rail-to-rail operation. Rail-to-Rail operation is achieved in the data converter …

International Students’ Adjustment Challenges In The United States: A Case Study Of West Virginia University, Lawrencia Baaba Okai

Graduate Theses, Dissertations, and Problem Reports (ETD)

International students face challenges as they endeavor to study abroad ranging from host government policies to the host country’s attitudes vis-à-vis foreign students and immigration. In some instances, they also face obstacles leaving their country of origin. The United States is the largest destination country with 24% of all international students worldwide, followed by the United Kingdom, Australia, France, and Germany. In the United States, international students make up about 6% of all college students. They make significant contributions to the United States economy and bring several benefits, particularly to federal and state governments. They contribute to the federal government’s …

Green Completion As A Mitigation For Btex Exposure In Gas Flaring: Nigeria Case Study (Exposure Assessment And Cost Model), Akintunde S. Akinyemi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gas flaring is an essential part of the oil and gas industry safety and waste management procedures; however, it presents a potential exposure to BTEX compounds, a group of Non-Methane Volatile Organic Compounds (NMVOC), within up to a 10-mile radius of the flare point. The physical and the psychological cost of the journey to work, make employees live close to the workplace. This study examined the perceived exposure of oil and gas industry workers to possible carcinogenic emissions outside the workplace. It looked at the outcomes of the exposure to BTEX through gas flaring drawing on archival data and using …

Mapping Surficial Geology In The New River Gorge National River And Bluestone National Scenic River, West Virginia, Using Lidar-Derived Digital Elevation Data, Marla K. Denicola

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this thesis was to determine if the surficial geology of Bluestone National Scenic River (BLUE) and New River Gorge National River (NERI), two areas of similar geology, can be mapped using visual interpretation methods applied to digital elevation models (DEMs) derived from light detection and ranging (LiDAR) data. Surficial geology in BLUE was field mapped using GPS, following definitions and characterizations for surficial geology units established with the guidance of Dr. J. Steven Kite. A 2m x 2m LiDAR-derived DEM was used for BLUE and most of NERI using US Army Corps of Engineers (USCOE) LiDAR data, …

Light And Shadow In Kaija Saariaho's Maan Varjot, Benjamin M. Cornelius-Bates

Graduate Theses, Dissertations, and Problem Reports (ETD)

Kaija Saariaho’s work Maan Varjot is a relatively new addition to a set of repertoire that includes the organ as a part of the orchestra. This commission from the Orchestre Symphonique de Montréal, Orchestre National de Lyon, Southbank Centre, and the Philharmonia Orchestra, was premiered in 2014 and features the organ as a timbral enhancement and contrast to the orchestra. The 52nd Stanza from the poem Adonais, written by Percy Shelley and dedicated to John Keats, provide an important insight into the analysis and interpretation of the work. Two lines in particular are important: “The One remains, the many change …

Applications Of Machine Learning Methods In Health Outcomes Research: Heart Failure In Women, Khalid Abdullah Alhussain

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is robust evidence that heart failure (HF) is associated with substantial mortality, morbidity, poor health-related quality of life, healthcare utilization, and economic burden. Previous research has revealed that there are sex differences in the epidemiology, etiology, and disease burden of HF. However, research on HF among women, especially postmenopausal women, is limited. To fill the knowledge gap, the three related aims of this dissertation were to: (1) identify knowledge gaps in HF research among women, especially postmenopausal women, using unsupervised machine learning methods and big data (i.e., articles published in PubMed); (2) identify emerging predictors (i.e., polypharmacy and some …