Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Engineering (783)
- Social and Behavioral Sciences (648)
- Life Sciences (513)
- Physical Sciences and Mathematics (501)
- Medicine and Health Sciences (458)
-
- Arts and Humanities (334)
- Psychology (253)
- Education (211)
- Mechanical Engineering (161)
- Civil and Environmental Engineering (142)
- Chemistry (128)
- Music (115)
- Chemical Engineering (113)
- Electrical and Computer Engineering (110)
- Business (94)
- Environmental Sciences (92)
- Earth Sciences (90)
- Civil Engineering (84)
- Materials Science and Engineering (83)
- Public Health (81)
- Music Performance (80)
- Communication (79)
- Computer Sciences (79)
- Nursing (79)
- Computer Engineering (77)
- Animal Sciences (75)
- History (75)
- Operations Research, Systems Engineering and Industrial Engineering (75)
- Neuroscience and Neurobiology (73)
- Ecology and Evolutionary Biology (67)
- Keyword
-
- Mechanical engineering (476)
- Electrical engineering (282)
- Civil engineering (254)
- Computer science (249)
- Forestry (156)
-
- Chemical engineering (152)
- Clinical psychology (152)
- Ecology (130)
- Behavioral psychology (116)
- Petroleum engineering (113)
- Aerospace engineering (112)
- Industrial engineering (112)
- Higher education (108)
- Economics (103)
- Environmental engineering (99)
- Geology (99)
- Animal sciences (97)
- Materials science (95)
- Molecular biology (94)
- Public health (90)
- Aquatic sciences (88)
- Mining engineering (88)
- Educational technology (86)
- Energy (84)
- Environmental science (84)
- Developmental psychology (83)
- Educational psychology (82)
- Dentistry (78)
- Machine Learning (75)
- Social psychology (71)
- Publication Year
- File Type
Articles 211 - 240 of 11969
Full-Text Articles in Entire DC Network
Microwave Calcination Techniques For Electrode And Electrolyte Powders In Fuel Cells, Logan Scott Proud
Microwave Calcination Techniques For Electrode And Electrolyte Powders In Fuel Cells, Logan Scott Proud
Graduate Theses, Dissertations, and Problem Reports (ETD)
This work investigates microwave-assisted calcination as a rapid, energy-efficient alternative to conventional resistive heating for the synthesis of complex oxide powders used in solid oxide electrochemical cells. Ce₀.₉Gd₀.₁O₁.₉₅ (GDC10) and La₀.₆Sr₀.₄Co₀.₂Fe₀.₈O₃–δ (LSCF6428) were synthesized via solid-state and co-precipitation routes to evaluate the influence of precursor chemistry and dielectric behavior on microwave coupling, reaction kinetics, and powder characteristics. Calcination was performed in single-mode and multimode microwave systems using a silicon carbide/alumina susceptor–insulation package to ensure controlled high-temperature processing. A parametric study examining ramp rate, sample size, and temperature revealed that microwave processing reduced calcination time to ~1 hour compared to >21 …
Simulation Optimization Of Intermodal Freight Transportation Under Disruptions, Israt Humayra
Simulation Optimization Of Intermodal Freight Transportation Under Disruptions, Israt Humayra
Graduate Theses, Dissertations, and Problem Reports (ETD)
Rapid growth in freight transportation in modern supply chains has led to increased operational costs, congestion, and severe environmental impacts, especially greenhouse gas emissions. Combining different modes, such as highway, railway, and waterway, intermodal transportation could thus offer considerable benefit to improve efficiency, sustainability, and resilience. However, most existing planning approaches rely on simplified assumptions, fixed schedules, and average cost estimates, making them less relevant to dealing with real-world uncertainties and disruptions. This study develops a simulation-optimization framework for intermodal freight transportation under disruption. We develop a mixed-integer programming model to represent an intermodal logistics planning framework on a multi-layered …
Public Perception Of Using Public Lands For Climate Change Mitigation, Casey Marie Zaitzew
Public Perception Of Using Public Lands For Climate Change Mitigation, Casey Marie Zaitzew
Graduate Theses, Dissertations, and Problem Reports (ETD)
Biological carbon sequestration provides a way to integrate carbon initiatives while meeting sustainable forestry management needs. In the United States, woody plants capture about 13% of annual carbon emissions, highlighting the importance of forests and other ecosystems in national climate strategies.With over 640 million acres of public land, management strategies that incorporate carbon sequestration could significantly influence national carbon storage. Because public lands are taxpayer-funded, public acceptance is critical in carbon-focused policies. While prior studies have examined public attitudes toward carbon capture and storage techniques, fewer studies have focused on biological sequestration within federally managed lands.
This study analyzes public …
Hyperglycemia Detection From Single-Lead Ecg Using A Hybrid Cnn & Transformer Model, Adam Ayomikun Ogunjembola
Hyperglycemia Detection From Single-Lead Ecg Using A Hybrid Cnn & Transformer Model, Adam Ayomikun Ogunjembola
Graduate Theses, Dissertations, and Problem Reports (ETD)
Diabetes Mellitus is known as high blood glucose. This high blood glucose level happens when the body has a problem with producing or using insulin. Insulin is a very important hormone that the pancreas makes to control how much glucose gets into the bloodstream and cells. Diabetes Mellitus has an effect on the body if it is not treated, such as damaging the blood vessels and nerves which can lead to stroke, kidney failure, heart attack and permanent loss of vision. Since people with diabetes need to measure their glucose levels in order to determine how much insulin or medicine …
Do You Walk On By? The Effects Of Donor Fatigue On Willingness To Donate, Shawn Michael Henry
Do You Walk On By? The Effects Of Donor Fatigue On Willingness To Donate, Shawn Michael Henry
Graduate Theses, Dissertations, and Problem Reports (ETD)
Donation solicitation literature validates the successful usage of various solicitation tactics that lead to achieving set donation goals for their associated cause. Yet, while the financial success of “checkout charity” is well-documented, a significant gap remains regarding the impact of high-frequency solicitations on long-term consumer-brand relationship. This research addresses this gap. Over the span of three surveys, this study finds that donation request frequency overall erodes donation likelihood through donor fatigue when donation frequency changes (occasional vs. always). However, this relationship is moderated by the perceived consumer base, with a larger perceived consumer base exacerbating the “diffusion of responsibility.” Further, …
How Regulatory Focus Shapes Adjustment And Performance In The Return-To-Office Era: The Roles Of Change Appraisal, Perceived Organizational Support, And Psychological Safety, Karen Jean Morris
Graduate Theses, Dissertations, and Problem Reports (ETD)
Abstract
The COVID-19 pandemic has significantly transformed workplace norms and employee expectations, marking a notable shift towards remote work. As organizations increasingly encourage a return to physical offices, understanding employee adaptation during this transition has become essential. This dissertation leverages Regulatory Focus Theory to explore how employees' promotion and prevention focus influences their adjustment and performance upon re-entering traditional office settings.
A parallel mediation model is proposed, in which Change Appraisal, Perceived Organizational Support (POS), and Psychological Safety (PS) are identified as key mechanisms linking regulatory focus to employee outcomes. The findings may provide evidence that individuals who exhibit a …
Congolese Journalists: Professional Identity And Legitimacy, Hannah L. Heiskell
Congolese Journalists: Professional Identity And Legitimacy, Hannah L. Heiskell
Graduate Theses, Dissertations, and Problem Reports (ETD)
This paper examines how Congolese journalists construct their professional identity
and legitimacy while working under conditions of conflict and state pressure, and how
international media outlets discursively represent them through Western journalistic norms.
Addressing previous research and centering local perspectives, this study uses critical
discourse analysis to compare language, framing, and narratives across Congolese and
international media texts, and the works in which they produce. Attention is given to how
agency, professionalism, and constraint are represented within each discourse. The analysis
focuses on metajournalistic discourse, or journalism talking about journalism, to examine
how professional norms and boundaries are articulated and …
Bi-Level Optimization Of Peer-To-Peer Trading In A Decentralized Energy Market, Marshal Miezah
Bi-Level Optimization Of Peer-To-Peer Trading In A Decentralized Energy Market, Marshal Miezah
Graduate Theses, Dissertations, and Problem Reports (ETD)
Distributed power generation based on rooftop photovoltaic (PV) systems integrated with battery storage emerges as a promising pathway for reducing greenhouse gas emissions and im- proving flexibility in modern power systems. This study develops a bi-level optimization model to examine how prosumers maximize profit through peer-to-peer (P2P) energy trading with consumers and the grid, and how consumers minimize cost by leveraging P2P trading. The bi-level problem is reformulated as a single-level mixed-integer programming (MIP) model using Karush- Kuhn-Tucker (KKT) conditions to improve tractability and preserve market-clearing behavior. For the model validation and case study development, prosumer and consumer data are …
Caring For The Caregiver: Implementing An Occupational Therapy-Tailored Educational Program To Alleviate Caregiver Burden, Lura Elizabeth Simons
Caring For The Caregiver: Implementing An Occupational Therapy-Tailored Educational Program To Alleviate Caregiver Burden, Lura Elizabeth Simons
Graduate Theses, Dissertations, and Problem Reports (ETD)
Caregivers of traumatic brain injury (TBI) survivors experience caregiver burden, which is a prevalent issue. The most significant concern is for symptoms of burden affecting mental health and sleep quality. This doctoral capstone project addressed the knowledge gap regarding programs that alleviate these signs and symptoms through evidence-based interventions. The objective was to create an educational program with modules that demonstrated improvement in satisfaction and content understanding through in-person sessions and individualized interviews with staff members. This project aimed to reduce perceived burden by conducting in-person sessions to implement interventions through an occupational therapy (OT) lens and by using educational …
Three Essays In Cpi Bias And Health Economics, Auderta Amoako-Nuamah
Three Essays In Cpi Bias And Health Economics, Auderta Amoako-Nuamah
Graduate Theses, Dissertations, and Problem Reports (ETD)
The first essay estimates bias in the Consumer Price Index (CPI) for elderly individuals in the United States using Engel curve methodology and household-level data from the Panel Study of Income Dynamics (1999–2023). The analysis focuses on how well the CPI reflects changes in the cost of living for older Americans, with particular attention to differences by gender and marital status. Results show that from 1999–2011, the CPI overstated the increase in the cost of living for both elderly and non-elderly households. In contrast, from 1999–2023, the CPI understated cost increases, with the bias generally larger for non-elderly households. Within …
Enhancing Occupational Engagement And Wellness In Middle-Aged And Retired Adults Through Movement And Mindfulness Program Development, Erin J. Harvey
Enhancing Occupational Engagement And Wellness In Middle-Aged And Retired Adults Through Movement And Mindfulness Program Development, Erin J. Harvey
Graduate Theses, Dissertations, and Problem Reports (ETD)
Occupational imbalance and a diminished sense of purpose are common challenges faced during middle age and the transition into retirement. These issues can contribute to increased burnout, decreased participation in meaningful activities, and an overall decline in health and well-being. Occupational therapy is well-equipped to address these concerns through comprehensive and holistic, occupation-based wellness programs that promote healthy routines and engagement in meaningful roles. This doctoral capstone project involved developing and implementing two community-based wellness programs tailored to different populations. The first program included self-paced wellness modules for middle-aged adults, aiming to encourage healthy lifestyle habits, enhance coping skills, and …
A Quality Improvement Initiative To Improve Central Line Insertion Care Using An Evidence- Based Practice Checklist, Jonathan Andre Barbour
A Quality Improvement Initiative To Improve Central Line Insertion Care Using An Evidence- Based Practice Checklist, Jonathan Andre Barbour
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Central line infections in a 33-bed Cardiovascular Intensive Care Unit (CVICU) at a large academic medical center located in the northeastern United States were increasing for patients after cardiovascular surgery. These infections could, potentially, lead to longer hospital stays and lost revenues for the health system. A project explored the implementation of an evidence-based practice (EBP) sterile procedure standardized checklist during central line insertions
Purpose: A quality improvement (QI) initiative project sought to improve central line insertion compliance while monitoring the bedside implementation of an EBP checklist.
Intervention: The Agency for Healthcare Research and Quality’s (AHRQ) Central line-associated bloodstream …
Disaster Exposure, The Perception Of Physiological Pain, And Psychological Distress Across Adulthood, Esha Azhar
Disaster Exposure, The Perception Of Physiological Pain, And Psychological Distress Across Adulthood, Esha Azhar
Graduate Theses, Dissertations, and Problem Reports (ETD)
Climate change brings with it an increase in the occurrence of natural disasters, such as hurricanes, wildfires, severe storms, etc. In the aftermath, afflicted individuals may suffer adversely, especially in their physical and mental health. Previous research has found older adults to be faring better after experiencing a disaster compared to younger adults, which has been attributed to their better mental health associated with aging and gaining experience with adversities (Strough et al., 2023; 2025). The current study examined the psychological distress and physiological pain of individuals across the adult lifespan after experiencing a disaster. Participants were part of the …
Development Of A Protocol To Improve The Use Of Diabetes-Specific Formula, Lauren Nicole Sanetrik
Development Of A Protocol To Improve The Use Of Diabetes-Specific Formula, Lauren Nicole Sanetrik
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: Enteral nutrition (EN) is often necessary for hospitalized patients who are unable to meet their nutritional needs orally. Patients with diabetes mellitus (DM) receiving EN are at risk of hyperglycemia, which contributes to poor wound healing, infection, and prolonged hospitalization. Diabetes-specific formulas (DSFs) are designed to optimize glycemic control compared with standard formulas (SFs); however, their use is inconsistent due to the absence of standardized protocols.
Purpose: The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to implement and evaluate a protocol to increase DSF utilization among patients with DM receiving EN, with the goal …
An Evidence-Based Practice Initiative To Promote Debriefing Within The Obstetrics Surgical Team, Rachel Lynn Runatz
An Evidence-Based Practice Initiative To Promote Debriefing Within The Obstetrics Surgical Team, Rachel Lynn Runatz
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: Operating room debriefing is an evidence-based strategy shown to improve communication, efficiency, patient safety, and safety culture; however, debriefing is inconsistently performed in obstetric operating rooms due to workflow, cultural, and time-related barriers.
Purpose: The purpose of this Doctor of Nursing Practice (DNP) project was to increase the frequency of debriefings in the Birthing Center operating rooms at WVU Medicine Children’s Hospital through implementation of a nurse-driven, evidence-based debriefing initiative.
Intervention: A nurse-driven debriefing protocol was implemented using the Iowa Implementation for Sustainability Framework. Interventions included staff education, accessible laminated debriefing documents, identification of nurse champions, leadership support, and …
The Effects Of Music Therapy On Anxiety And Sedation Requirements For Total Knee Arthroplasty Patients Undergoing Regional Anesthesia: An Evidence-Based Practice Pilot Initiative, Kyra Marie Savrese
The Effects Of Music Therapy On Anxiety And Sedation Requirements For Total Knee Arthroplasty Patients Undergoing Regional Anesthesia: An Evidence-Based Practice Pilot Initiative, Kyra Marie Savrese
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: Excessive noise in the operating room negatively impacts patient comfort and outcomes, particularly in patients undergoing spinal anesthesia who have the potential for awareness.
Background: Research demonstrates that music therapy is a low-cost, low-risk intervention that reduces perioperative anxiety and sedative requirements. Literature supports the use of music as an adjunct to anesthesia care, especially in orthopedic populations.
Purpose: At J.W. Ruby Memorial Hospital, orthopedic procedures with regional anesthesia expose patients to high noise levels, often leading to increased anxiety, sedation use, and longer recovery times. Addressing this problem aligns with institution goals for safe, patient-centered care.
Methods: Using …
Behavioral Adaptation To Systematically Changing Local Conditions Of Reinforcement, Kento Yasukawa
Behavioral Adaptation To Systematically Changing Local Conditions Of Reinforcement, Kento Yasukawa
Graduate Theses, Dissertations, and Problem Reports (ETD)
Adaptation is the continual process of behavioral change in response to changes in environmental contingencies. One example of adaptation is to track the temporal distribution of reinforcers. The present dissertation investigated how responding tracked cyclically changing reinforcement schedules (i.e., cyclic interval [CI]) and how such tracking was influenced by concurrently available alternative reinforcement schedules. Across two experiments, four pigeons responded under a CI 60-s schedule in which the interreinforcer intervals (IRIs) changed systematically according to a sinusoidal function. The primary dependent variable was postreinforcement pauses (PRPs), with local response rates (response rates per IRI) examined as a secondary measure of …
Resilience And Reactivity: The Relation Between John Henryism And Cardiovascular Responses To Laboratory Stressors In An Appalachian Sample, Emma Raycher Thompson
Resilience And Reactivity: The Relation Between John Henryism And Cardiovascular Responses To Laboratory Stressors In An Appalachian Sample, Emma Raycher Thompson
Graduate Theses, Dissertations, and Problem Reports (ETD)
John Henryism active coping (JHAC), named for folk hero John Henry, is defined as the perception that one can overcome stressors through hard work (James et al., 1983). This construct has been tied to numerous health outcomes, showing a negative influence on cardiovascular health (Bennett et al., 2004). Many researchers have examined the relation between JHAC and cardiovascular reactivity to stress, though findings are mixed. Further, despite the legend of John Henry occurring in Appalachia, and traits associated with John Henryism, such as resilience, being prominent within this region, no study has examined the relation between JHAC and reactivity in …
Elucidating Structure–Reactivity Relationships In Ni-Catalyzed Co2 Methanation, Majed Alam Abir
Elucidating Structure–Reactivity Relationships In Ni-Catalyzed Co2 Methanation, Majed Alam Abir
Graduate Theses, Dissertations, and Problem Reports (ETD)
The catalytic hydrogenation of carbon dioxide (CO2) to methane represents a promising strategy for carbon utilization and renewable energy storage within power-to-gas systems. When coupled with hydrogen derived from renewable electricity, CO2 methanation enables the conversion of intermittent energy sources into storable and transportable chemical fuels compatible with existing natural gas infrastructure. Nickel-based catalysts have emerged as leading candidates for this reaction due to their high activity towards CO2 methanation, abundance, and cost. However, the performance and long-term stability of Ni catalysts are strongly influenced by catalyst support properties, Ni nanoparticle size, and promoter effect, and …
Posttraumatic Growth In Appalachian Youth: Findings From An Outpatient Pediatric Trauma Specialty Clinic, Marinne M. Morgan
Posttraumatic Growth In Appalachian Youth: Findings From An Outpatient Pediatric Trauma Specialty Clinic, Marinne M. Morgan
Graduate Theses, Dissertations, and Problem Reports (ETD)
Childhood traumatic event exposure (CTE) involves exposure to extreme events that overwhelm one’s ability to cope. Childhood traumatic event exposure has been linked to a wide range of adverse mental and physical health consequences, including posttraumatic stress symptoms (PTSS). Fewer studies have examined positive trajectories following childhood traumatic event exposure, such as posttraumatic growth (PTG), especially in understudied regions such as Appalachia. The current study used a cross-sectional design to examine posttraumatic growth in 14 youths aged 9 to 15 years seeking trauma-focused therapeutic services at an outpatient pediatric trauma specialty clinic in West Virginia. In line with previous research, …
Evaluation Of Potential Factors Limiting The Expansion Of Invasive Carp (Hypophthalmichthys Spp.) In The Ohio River Basin, Erin Shepta
Graduate Theses, Dissertations, and Problem Reports (ETD)
The introduction of aquatic invasive species is one of the greatest threats to freshwater biodiversity around the world. Two species of invasive carp, bighead carp (Hypophthalmichthys nobilis) and silver carp (H. molitrix) have spread throughout much of the Mississippi River Basin, resulting in serious ecological impacts to native communities. Their spread in the Ohio River, a major tributary of the Mississippi River, appears to have slowed, with limited evidence of upstream advancements. Here, we investigated abiotic and biotic factors that may be contributing to the reduced spread of invasive carp in the Ohio River Basin. Generally, …
Exploring The Intersectionality Of Sociodemographic Factors And Adverse Childhood Experiences That Impact College Performance, Taylor June Brown
Exploring The Intersectionality Of Sociodemographic Factors And Adverse Childhood Experiences That Impact College Performance, Taylor June Brown
Graduate Theses, Dissertations, and Problem Reports (ETD)
Success in higher education is influenced by a range of social and economic factors that do not affect all students equally. This thesis examined how Adverse Childhood Experiences (ACEs), socioeconomic status (SES), first-generation college status, minority status, and geographic isolation independently and multiplicatively relate to academic outcomes. Using data from 775 first-year students at a large public university in rural Appalachia, this study assessed whether these factors independently and/or multiplicatively predicted first-year GPA and odds of dropping out. ACEs linearly predicted first-year cumulative GPA and odds of dropping out. A significant ACE x Race interaction emerged for predicting first-year cumulative …
Feasibility Of Parent-Child Interaction Therapy-Toddler In Community Clinics In The United States And Japan, Sharon T. Phillips
Feasibility Of Parent-Child Interaction Therapy-Toddler In Community Clinics In The United States And Japan, Sharon T. Phillips
Graduate Theses, Dissertations, and Problem Reports (ETD)
The toddler age (12-36 months) is characterized by a toddler’s increasing desire for autonomy, which can result in caregiver-child conflict and toddler externalizing problems (Kohlhoff & Morgan, 2014). Clinical levels of disruptive behavior in toddlerhood can be predictive of a host of negative outcomes, including problems with academic achievement and delinquency (Copeland et al., 2007; Milledge et al., 2019). High levels of toddler behavior problems also are associated with poor caregiver-child relationships and poor toddler emotion regulation skills (Beijers et al., 2013; Umemura et al., 2022). Thus, interventions targeting toddler behavior problems need to focus on strengthening the caregiver-child relationship …
Do Transdiagnostic Factors Predict Emotion Recognition?, Grace L. Wheeler
Do Transdiagnostic Factors Predict Emotion Recognition?, Grace L. Wheeler
Graduate Theses, Dissertations, and Problem Reports (ETD)
While emotion recognition deficits have been found in several anxiety and related disorders (e.g., social anxiety, obsessive-compulsive), consistent results have not been established. To clarify the relationship between emotion recognition abilities and anxiety, the current study tested if transdiagnostic factors related to anxiety are predictors of emotion recognition abilities. Data was analyzed from participants (N = 188) recruited via CloudResearch; they completed measures of three transdiagnostic factors related to anxiety (e.g., anxiety sensitivity, intolerance of uncertainty, and rumination), followed by an emotion recognition task. Multiple regression analyses revealed higher levels of anxiety sensitivity predicted worse recognition for anger, disgust, …
Swarm Of One: Self-Organization In Multicellular Robots, Trevor Riley Smith
Swarm Of One: Self-Organization In Multicellular Robots, Trevor Riley Smith
Graduate Theses, Dissertations, and Problem Reports (ETD)
Designing robots traditionally relies on centralized, top-down methods that constrain adaptability and resiliency, producing systems optimized for specific tasks. However, such systems often fail in complex environments, such as extraterrestrial, disaster, or natural settings, where designers cannot foresee every scenario a robot may encounter. Achieving autonomy in these contexts requires robots that are resilient and capable of adapting to the unknown. Multicellular organisms exhibit this adaptability through self-organization, where complex structures and behaviors emerge from local interactions among their cells. Such organisms can be viewed simultaneously as a single entity and a swarm of cooperating cells, i.e., a Swarm-of-One.
This …
A New Parsimony-Based Method For Reconstructing Sequences Of Developmental Events And Estimating Rates Of Intraspecific Variation, With Applications To Trilobites, Alexander Benjamin Bradley
A New Parsimony-Based Method For Reconstructing Sequences Of Developmental Events And Estimating Rates Of Intraspecific Variation, With Applications To Trilobites, Alexander Benjamin Bradley
Graduate Theses, Dissertations, and Problem Reports (ETD)
Ontogenetic Sequence Analysis (OSA) is a method for reconstructing multiple sequences of abrupt phenotypic transformations (developmental events) for sampled populations of any kind of organism. It makes use of cladistic parsimony software to produce a network, or graph, whose vertices represent unique phenotypes at different stages of maturity (“semaphoronts”) and whose edges describe the developmental events occurring between semaphoronts. It is a powerful tool for constraining the range of developmental variation possible for a given species and generating sample statistics capable of identifying both the most common and the outlier ontogenetic sequences. However, OSA has seen little use since its …
Mechanisms Of Glyphosate Toxicity: Uptake, Mitochondrial Function, And Metabolism, Dionysios Patriarcheas
Mechanisms Of Glyphosate Toxicity: Uptake, Mitochondrial Function, And Metabolism, Dionysios Patriarcheas
Graduate Theses, Dissertations, and Problem Reports (ETD)
Glyphosate, the most widely used herbicide in the world, is an inhibitor of chorismate biosynthesis, the precursor of aromatic amino acids. The target of glyphosate is absent in animals, but findings reporting toxicity in model organisms without a known mechanism or target are increasing. Saccharomyces cerevisiae is a useful and versatile model for understanding molecular mechanisms of toxicity. In yeast, previous work has shown that the aspartate/glutamate permease Dip5 is the proposed transporter for glyphosate and that mitochondrial metabolism has been implicated in response to glyphosate toxicity. This dissertation aimed to identify the effects of glyphosate on mitochondrial function through …
Multi-Omic Characterization Of Immune And Metabolic Responses To Inflammatory Challenges In Sheep, Samanthia Raceine Johnson
Multi-Omic Characterization Of Immune And Metabolic Responses To Inflammatory Challenges In Sheep, Samanthia Raceine Johnson
Graduate Theses, Dissertations, and Problem Reports (ETD)
To meet the demands of the growing population, it is imperative to develop sustainable and applicable ways to improve animal health and productivity. The first step in doing so is understanding the mechanisms that govern health and immune response and find ways to appropriately modulate them to improve animal health and productivity. The objective of this study is to use multi-omic techniques to understand breed-specific immune responses in sheep that may contribute to their resistance and susceptibility to parasites and to a greater extent, immunocompetence. Known parasite-resistant breed, St. Croix (STC) were compared to parasite susceptible Suffolk (SUF) sheep for …
Development Of Novel Methods For Investigative Leads In Firearm And Explosive Related Incidents, Addio Joseph Fiordigigli Jr.
Development Of Novel Methods For Investigative Leads In Firearm And Explosive Related Incidents, Addio Joseph Fiordigigli Jr.
Graduate Theses, Dissertations, and Problem Reports (ETD)
Criminal outbreaks and gun violence persist as a multifaceted global crisis, marked by escalating rates of homicide, suicide, and terrorism that destabilize communities and strain public resources. The proliferation of illicit firearms and homemade explosive devices, along with the complexity of modern criminal networks, necessitates innovative scientific tools to strengthen preventive intelligence operations and ensure that the legal process is grounded in physical evidence. More efficient detection of traces left behind at a crime scene can help prevent further harm or injury from follow-up attacks. This study aims to develop and evaluate new triage methods for characterizing gunshot residues (GSR) …
Improving Sedative Administration In Patients Receiving Paralytics During Intubation: A Quality Improvement Initiative Within A Large Academic Medical Center In West Virginia, David Bryon Underwood
Improving Sedative Administration In Patients Receiving Paralytics During Intubation: A Quality Improvement Initiative Within A Large Academic Medical Center In West Virginia, David Bryon Underwood
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: Awake paralysis (AWP) occurs when long-acting neuromuscular blockers outlast short-acting sedatives during intubation, leaving patients chemically paralyzed but conscious. This highlights the critical need for timely post-intubation sedation.
Background: A 2024 review in the Neurological Critical Care Unit (NCCU) revealed that 72% of patients who received rocuronium were not given a post-intubation sedative. The difference in duration of action of paralyzing agents versus sedatives can result in patients being conscious while paralyzed, potentially resulting in hemodynamic instability and psychological harm.
Purpose: The quality improvement initiative aimed to reduce the number of patients receiving neuromuscular blocking agents without post-intubation sedation. …