Digital Commons Network^™

Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor

Graduate Theses, Dissertations, and Problem Reports (ETD)

The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge …

A Short Film That Addresses Substance Use Disorders In Rural Communities And Strategies In Prevention And Treatment Of Addiction, Sarah R. Poteracki

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research paper and accompanying video (link to the short film is here: https://drive.google.com/drive/folders/1etDnUmEvkOds8J0EKnq1gnFO79-GggjY) offer insight into the current state of research collaboration surrounding substance use disorders in West Virginia. This professional project explores the importance of collaboration both in a research and clinical setting and in the social realm. The film was shown at the 2nd annual meeting for the Appalachian Node of the National Institute on Drug Abuse Clinical Trials Network on February 25, 2021. I interviewed 14 researchers and experts from a diverse range of disciplines who shared insights and strategies in the prevention and treatment of …

Staying Power: Examining Resistance In West Virginia, Beth Nardella

Graduate Theses, Dissertations, and Problem Reports (ETD)

West Virginia has been plagued with high unemployment rates, high rates of addiction and poverty, and some of the worst health outcomes in the country. Outmigration has been the paradigm for many, but why do some people choose to stay? Numerous scholars have written about outmigration, but there is little information on why people stay. After decades of people leaving, many who remain have made a choice to stay. This choice can be seen as an act of resistance against the problematic discourses surrounding the Appalachian region and the economic disparities found within rural communities. West Virginians are often dependent …

The Impacts Of An Entrepreneurial Course On Secondary Students' Entrepreneurial Self-Efficacy And Entrepreneurial Intentions, Toi E. Hershman

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is considerable agreement that promoting entrepreneurship stimulates economic development and job creation, which helps maintain a country’s economic competitiveness. Entrepreneurship education is a key to increasing the likelihood of potential entrepreneurs. While substantial research has documented strategies for enhancing students' entrepreneurial mindset and building entrepreneurial skills in higher education, entrepreneurship is rarely incorporated into or studied in secondary education. This mixed-method study examined the impact of an online ten-lesson entrepreneurship course on secondary students' entrepreneurial self-efficacy and entrepreneurial intentions. Students took a pre-survey that measured their entrepreneurial self-efficacy and intentions before the course and a post-survey upon completing the …

Deep Fingerprint Matching From Contactless To Contact Fingerprints For Increased Interoperability, Alexander James Wilson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Contactless fingerprint matching is a common form of biometric security today. Most smartphones and associated apps now let users opt into using this form of biometric security. However, it’s difficult to match a finger-photo to a fingerprint because of perspective distortion occurring at the edges of the finger-photo, so direct matching using conventional methods will not be as accurate due to a lack of sufficient matching minutiae points. To address this issue, we propose a deep model, Perspective Distortion Rectification Model (PDRM), to estimate the fingerprint correspondence for finger-photo images in order to recover more minutiae points. Not only do …

Design Of Bending Moment And Load Capacity Test For Frp Sheet Piles, Joshua Larry Wilt Mr.

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sheet piles consist of numerous interlocked segments that form temporary or permanent support walls and serve as the primary foundational component across a variety of civil infrastructural applications, such as below-grade parking structures or sea walls. The installation of sheet piles is particularly advantageous in coastal areas, as dewatering of the site is unnecessary. Steel is commonly used for sheet piles due to its strength and ease of manufacturing; however, in the presence of saltwater steel begins to rust. Contrary to steel and concrete, fiber reinforced polymer (FRP) composite sheet piles are resistant to chlorides and have considerably higher corrosion …

Remediation Of Spatial Skills In First Semester Calculus Using Haptics-Based Applications, Kristen L. Murphy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Spatial reasoning is required for many topics in undergraduate mathematics as well as other STEM fields. In calculus specifically, there are few interventions that assess students’ spatial skills and provide remediation. Haptic technology is a novel approach to spatial skills remediation due to its unfamiliarity to students and its flexibility with regard to models. The purpose of this dissertation is two-fold: first, to determine what level of spatial abilities students possess upon entering an undergraduate calculus course, and second, to determine whether haptic feedback will enhance an intervention for improving spatial skills.

The dissertation research was a mixed-methods study using …

A Parametric Study Of Lateral-Torsional Buckling In Pultruded Frp Beams Using Abaqus, Robert Nathaniel Baylor

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fiber Reinforced Polymer (FRP) composites continue to gain popularity in civil and mechanical infrastructure due to a high strength-to-weight ratio, corrosion-resistance, and low maintenance requirements. FRP can also fulfill niche roles requiring non-conductivity and magnetic transparency. The longitudinal forming of pultruded FRP makes it a natural choice for lightweight beams. Although FRP composites have a high strength for their weight, the elastic and shear moduli for glass FRP may only be 1/7 and 1/30 that of steel, respectively. These low stiffnesses make FRP composite beams particularly susceptible to lateral-torsional buckling (LTB). In addition, the low shear to elastic stiffness amplifies …

Sevoflurane: Practice Change Integration Quality Improvement For Pharmacoeconomic Accountability, Kelly Moore Meyers

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Pharmacoeconomic accountability is increasingly of concern to patients, institutions, and healthcare payors alike. Annual sevoflurane expenditure at a large university hospital exceeds $300,000 (personal communication, Eric Likar). Sevoflurane is a liquid, volatile anesthetic delivered from a vaporizer, through a breathing circuit to a patient. Multiple studies focused on reducing sevoflurane use note significant cost savings were attained with a variety of techniques. Moreover, using less sevoflurane reduces the environmental impact of volatile agents which are potent greenhouse gases. Through simple interventions, such as a brief staff education and reminders, Lethbridge et al. (2007) demonstrated over a fifty-percent reduction in …

Improving Performance And Durability Of Intermediate Temperature Proton‐Conducting Solid Oxide Electrolysis Cells Via Materials Design And Catalyst Surface Engineering, Hanchen Tian

Graduate Theses, Dissertations, and Problem Reports (ETD)

Solid oxide steam electrolysis cell, a promising electrical-chemical conversion device for the next generation efficient hydrogen production and energy storage, has been actively studied because of their high energy conversion efficiencies and prospective applications as electrochemical reactors. After decades of research on protonic ceramic materials, remarkable advances have been made in the protonic ceramic electrochemical cells (PCECs) air electrode and electrolyte. However, the existing air electrodes are far from satisfying the requirements of practical applications, a series of issues, including the lack of active and durable electrodes, greatly limit the commercialization. To date, the systematic development of triple conducting catalysts …

Understanding Visitor Use At Florida Keys National Marine Sanctuary, Melissa Maria Hurtado Alvarez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Effective management and monitoring of visitor recreational use is fundamental in marine protected areas. It is common to hear that tourism and outdoor recreation are often qualified as double-edged activities, making valuable socioeconomic contributions but also causing degradation of the environment. The convergence of social and natural resource research and practices can help managers to create better policies that will maximize human benefits from, and minimize human pressures on, ocean and coastal environments. For this study online surveys were sent via Qualtrics to email addresses obtained from the state of Florida during the summer of 2020. The first paper assessed …

Re-Design Of Precision Signal Conditioning Circuit For Detecting Schumann Resonance, Rohith Bikkina

Graduate Theses, Dissertations, and Problem Reports (ETD)

Extremely low frequencies signals are waves between 3 to 30Hz and corresponding wavelengths between 10,000 to 100,000 kilometers. The specific signals used here are generated from lightning and are excited at frequencies around 8Hz, 14Hz, 20Hz. These are often called Schumann Resonance frequencies. Several stations have been built around the world for identifying ELF waves. All of those required a sparsely populated area that was far away from electric power lines because of interference from electric noise at 50 Hz and 60Hz. This project develops and tests an amplifier and filter circuit that should assist in identifying the Schumann Resonance …

Development Of Eccentric Black Hole Binary Searches In The Ligo And Pta Regimes, Belinda D. Cheeseboro

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past several years, a plethora of gravitational wave events have been detected leading to better understanding of binary black holes, binary neutron stars, and neutron star black hole binaries. All of these transient detections have helped us better understand the dynamics of these systems as well as the populations of these objects, but each of these sources was detected with models that neglected eccentricity. Eccentricity is one of several potential markers for determining the formation of binary systems. Detecting gravitational waves from eccentric sources can better our understanding of such systems and help constrain theories about their formation. …

Essays In Spatial And Regional Economics, Mohamed Shabani Kariburyo

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation consists of three essays in spatial and regional economics. In the first essay, high rates of chronic diseases and increasing nutritional polarization between different income groups in the United States are shown to be issues that should concern policymakers and public health officials. Spatial differences in access to food are evaluated as the cause of these nutritional inequalities. In this essay, hot and cold spots for food providers are determined throughout the state of West Virginia and then those places are used in a quasi-experimental method (entropy balancing) to study the effects of hot and cold spots on …

Quantitation Of Fentanyl And Metabolites From Blow Fly Tissue And Development Effects Of Fentanyl On Lucilia Sericata, Joseph Allen Cox

Graduate Theses, Dissertations, and Problem Reports (ETD)

Death investigations often involve collaborative work between different forensic disciplines, especially with regards to pathology, toxicology, and entomology. This dissertation investigates the effects of designer opioids on the development of blow fly (Lucilia sericata) larvae and the ability to detect and quantify the drugs and/or metabolites present in each stage of the fly’s life cycle. Therefore, we evaluated human tissue fortified with fentanyl at four treatment concentrations, and blow fly larvae were placed to feed on the drug infused tissue. A quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction method was developed, validated, and applied to extract …

Planning Algorithms Under Uncertainty For A Team Of A Uav And A Ugv For Underground Exploration, Matteo De Petrillo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Robots’ autonomy has been studied for decades in different environments, but only recently, thanks to the advance in technology and interests, robots for underground exploration gained more attention. Due to the many challenges that any robot must face in such harsh environments, this remains an challenging and complex problem to solve.

As technology became cheaper and more accessible, the use of robots for underground ex- ploration increased. One of the main challenges is concerned with robot localization, which is not easily provided by any Global Navigation Services System (GNSS). Many developments have been achieved for indoor mobile ground robots, making …

The Effect Of Bilingual Proficiency In Indian English On Bilabial Plosive, Taniya Chawla

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Bilingual speech production studies have highlighted that level of proficiency influences the acoustic-phonetic representation of phonemes in both languages (MacKay, Flege, Piske, & Schirru 2001; Zárate-Sández, 2015). The results for bilingual speech production reveal that proficient/early bilinguals produce distinct acoustic properties for the same phoneme in each language, whereas less proficient/late bilinguals produce acoustic properties for a phoneme that is closer to the native language (Flege et al., 2003; Fowler et al., 2008). Acoustic-phonetic studies for Hindi (L1) and Indian English (L2) for bilingual speakers have been understudied, and the level of proficiency has not been considered in Hindi …

Development Of Multi-Catchment Rating Curves For Streams Of Appalachian Mixed-Land-Use Watersheds: Preliminary Results, Zachary A. Heck

Graduate Theses, Dissertations, and Problem Reports (ETD)

Anthropogenic activities can alter the quantity and quality of water. Traditional monitoring of streamflow involves measurements of stage (mm), or water height, and discharge (i.e., streamflow) (m3 s -1 ) above a local datum. However, while stage is relatively easily monitored, continuous streamflow measurement is often impractical and prohibitively expensive. To address this challenge, rating curve equations can be developed to convert stage to flow. To establish a series of rating curves for flow estimations in Appalachia, an investigation was conducted in a representative urbanizing, mixed-land-use watershed in north-central West Virginia consisting of 21 nested stream gauge sites. At each …

Variations In Produced Water Chemistry And Relation To Regional Geology And Production In The Marcellus Shale, Northcentral West Virginia, Jonathan M. Brady

Graduate Theses, Dissertations, and Problem Reports (ETD)

An investigation of 74 Marcellus Shale wells across northcentral West Virginia indicates changes in produced water chemistry and quantity can be related to geologic conditions based on well logs and core data. These changes are determined by reviewing multiple produced water analyses for individual wells for periods up to ten years. Results show variations among the areas in this study. From west to east across central Harrison County to central Taylor County, then north into Monongalia County, gamma-ray logs show increasing intensity, especially in the middle and lower Marcellus. XRD mineralogy from core data shows increasing clay content from west …

Environmental Controls On The Terrestrial Water Cycle In Forested Mountain Ecosystems., Luis Andrés Guillén

Graduate Theses, Dissertations, and Problem Reports (ETD)

Water is a key resource to natural ecosystems and human societies alike, and the water cycle is fundamentally linked to the climate and the characteristics of catchments. However, the challenges posed by environmental change makes it imperative to understand how the water cycle is affected by biotic and abiotic factors, in particular, in areas that are crucial sources of water like forested headwater catchments. Therefore, this doctoral dissertation aims to advance the knowledge on the dynamics between climate, vegetation and landscape that determine the water balance of forested mountain ecosystems. This document presents five chapters, an introductory chapter, three standalone …

Doctors, Miners, And Black Lung: A Transatlantic Comparison Of Organized Medicine's Role In The Fight For Black Lung Recognition In West Virginia And Wales, Mollie M. Cecil Md

Graduate Theses, Dissertations, and Problem Reports (ETD)

Black lung disease is a crippling occupational lung disease experienced by coal miners throughout the world. However, this disease was not always recognized by the medical profession and required significant efforts on the part of miners’ unions to force mainstream recognition. The historiography on the subject is limited, especially with respect to the relationship between organized medicine and organized labor. This work further explores this relationship, particularly how this relationship differed between the parties in Wales and in West Virginia. In doing so, it portrays a more detailed picture of the fight for black lung recognition as well as highlights …

Soil Response Of Helicopter Liming In The Monongahela National Forest, Jarrett Douglas Fowler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Soils in the Monongahela National Forest (MNF) are acidic due to sandstone parent material, acid deposition, uptake of base cations by vegetation, and release of organic acids by organic matter (OM) decomposition. Increases in soil acidity have caused declines in forest health and changed species composition and nutrient status. Liming can neutralize soil acidity, but no large-scale liming projects have been done on acid forest soils in the USA. In anticipation of acquiring funding for a proposed liming project in the MNF, in 2007 and 2009 10 sites were selected to sample and analyze soils before lime was applied. In …

Manipulating The Perineuronal Net In The Deep Cerebellar Nucleus, Deidre E. O'Dell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Perineuronal nets (PNN) are a type of specialized extracellular matrix in the central nervous system. The PNN forms during postnatal development but the ontogeny of the PNN has yet to be elucidated. Studying the PNN in the rat brain may allow us to further understand the PNN’s role in development, learning, and memory. The PNN is fully developed in the deep cerebellar nuclei (DCN) of rats by post-natal day 18. By using enzymatic digestion of the PNN with chondroitinase ABC (ChABC), we studied how digestion of the PNN affects cerebellar-dependent eyeblink conditioning (EBC) and performed electrophysiological recordings from DCN neurons. …

Bravery In The Delicate: An Actor's Exploration Of Thea Elvsted In Henrik Ibsen's Hedda Gabler, Mary Catherine Goff

Graduate Theses, Dissertations, and Problem Reports (ETD)

This purpose of this document is twofold: to examine the process of character creation over the course of my experiences performing the role of Thea Elvsted in West Virginia University’s spring 2020 production of Henrik Ibsen’s Hedda Gabler, and to define Thea’s dramatic significance to Hedda Gabler as a whole. The following text will provide a detailed look at the research I collected in the interest of building a cohesive view of the world of the play. Additionally, it will describe the various techniques I employed throughout the rehearsal and performance process of the production, with specific attention paid to …

Equilibrium And Non-Equilibrium Ultrafast Carrier Transport And Dynamics In Chalcopyrite Semiconductors, Rishmali Thanuja Sooriyagoda

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chalcopyrite crystals in the II-IV-V₂ family have received significant interest due to their high nonlinearity, composition-tunable bandgaps, wide transparency windows, and high damage threshold. These semiconductors have been explored for electromagnetic (EM) screening, spintronic and photovoltaic applications, making them good optical and optoelectronic materials. This thesis uses terahertz spectroscopy to understand optical, electronic, and vibrational dynamical processes in CdGeP₂, ZnGeP₂ and CdSiP₂ chalcopyrite semiconductors.

We have employed Terahertz time-domain spectroscopy to investigate temperature-dependent ground-state properties of bulk chalcopyrite crystals that can be related to electronic transport and electron-lattice interactions. The complex spectra provide refraction and …

Effect Of Oxidative Breakers On Organic Matter Degradation, Contaminant Mobility And Critical Mineral Release During Shale-Fracturing Fluid Interactions In The Marcellus Shale, Shaun Donmoyer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Production of oil and gas from organic-rich shale formations has become viable through advancements in multi-stage hydraulic fracturing. The decline of shale gas production after the initial days of fracturing operations coupled with falling oil and gas prices, has pushed industry operators to use new chemical additives as an attempt to increase hydrocarbon production. The implementation of highly reactive fracturing fluids that include strong oxidizing agents, pose as a potential solution to increase well productivity. Strong oxidizing chemicals commonly known in fracturing operations as breakers, are used to improve the viscosity of gel-based fluids after the proppant is transported into …

Dynamic Optimization Algorithms For Baseload Power Plant Cycling Under Variable Renewable Energy, Rebecca Hyen Hae Kim

Graduate Theses, Dissertations, and Problem Reports (ETD)

The growing deployment of variable renewable energy (VRE) sources, such as wind and solar, is mainly due to the decline in the cost of renewable technologies and the increase of societal and cultural pressures. Solar and wind power generation are also known to have zero marginal costs and fuel emissions during dispatch. Thereby, the VRE from these sources should be prioritized when available. However, the rapid deployment of VRE has heightened concerns regarding the challenges in the integration between fossil-fueled and renewable energy systems. The high variability introduced by the VRE as well as the limited alignment between demand and …

Weed Recognition In Agriculture: A Mask R-Cnn Approach, Sruthi Keerthi Valicharla

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent interdisciplinary collaboration on deep learning has led to a growing interest in its application in the agriculture domain. Weed control and management are some of the crucial tasks in agriculture to maintain high crop productivity. The inception phase of weed control and management is to successfully recognize the weed plants, followed by providing a suitable management plan. Due to the complexities in agriculture images, such as similar colour and texture, we need to incorporate a deep neural network that uses pixel-wise grouping for identifying the plant species. In this thesis, we analysed the performance of one of the most …

Innovations In Money And Banking Markets, Eduardo Guimaraes Minuci

Graduate Theses, Dissertations, and Problem Reports (ETD)

The U.S. banking industry has experienced several technological and banking regulatory changes in the past two decades. This dissertation is composed of three papers that review and investigate how these banking and technological innovations have impacted depositors, bank provision of monetary assets, and bank performance. The order in which the papers are presented follows the order in which they were produced as the production of one paper helped spark ideas that led to the next.

Motivated by the fact that money has become more heterogeneous in terms of its returns, Chapter 1 focus on innovations in money markets by focusing …

Effects Of Changes In Land Use Land Cover And Climate On Long-Term Total Dissolved Solids Trends In The Mid-Atlantic Region Of The United States, Melaine Edouard Kolimedje

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Mid-Atlantic region (MAR) of the U.S. is subjected to a variety of stressors that affect the headwaters of the major rivers. Some of these stressors are abandoned mine drainage, agriculture, municipal point sources, urban areas, out-of-basin diversions, competing water uses, rapid population growths in the lowlands, alterations in water availability due to climate change and habitat alteration. In addition to these regional stressors, the rapid population growths and energy sources shifting have resulted in changes in land use and land cover (LULC) over the last few decades. The interactive effects of LULC and interannual/long-term climate changes have resulted in …