Digital Commons Network^™

3d Printed Microfluidic Devices For Advanced Fluid Manipulation In Biomedical Applications, Kathrine Curtin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microfluidics are valuable devices in the biomedical field because of their remarkable ability to manipulate small volumes of fluid and facilitate reactions. Microfluidics have several significant advantages, including their portability, low cost, fast reaction times, and high surface area-to-volume ratios. Microfluidics be used for a multitude of applications, including bioanalysis, cellular assays, organ-on-a-chip, and separations. Microfluidics have great potential to overcome many challenges in conventional chemical and biological applications. However, complex fabrication procedures in silicon, glass, thermoplastics, and (polydimethylsiloxane) PDMS devices make rapidly optimizing and prototyping devices challenging. Microfluidic fabrication techniques have been a long-standing challenge in successfully translating these …

Fife And Drum As A Secondary Ensemble Within The Public Schools, Travis Lee Nestor

Graduate Theses, Dissertations, and Problem Reports (ETD)

Acknowledging the framework of music education within the American public school system, this research will develop a process for creating and integrating the traditional fife and drum ensemble into the public school schedule as a secondary performance ensemble, specifically as applied to the public school system within the state of West Virginia. The research will provide a template that educators can follow that will aid them in designing the course; building student interest and participation; then finally to creating an official course that students can register to take within the school schedule.

Ultimately, this research looks to provide a process …

Modeling And Simulation Of A Process That Converts Ethane To Ethylene And Ethylene To Low Density Polyethylene, Ernest Bosire Mokaya

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ethylene is a critical feedstock and a major building block in the petrochemical industry that is used in synthesizing important products like polyethylene, ethanol, ethylene oxide, ethylene dichloride and ethylbenzene. With increasing demand of plastics, production of ethylene and subsequently polyethylene has increased globally. This thesis conducts the modeling and simulation of an integrated process that utilizes ethane as the primary feedstock to produce ethylene and the subsequent polymerization of ethylene to low-density polyethylene (LDPE). The process combines two different processes into one integrated process: (1) conversion of ethane to ethylene and (2) conversion of ethylene to LDPE. First, a …

Machine Learning Assisted Framework For Advanced Subsurface Fracture Mapping And Well Interference Quantification, Mohammad Faiq Adenan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The oil and gas industry has historically spent significant amount of capital to acquire large volumes of analog and digital data often left unused due to lack of digital awareness. It has instead relied on individual expertise and numerical modelling for reservoir development, characterization, and simulation, which is extremely time consuming and expensive and inevitably invites significant human bias and error into the equation. One of the major questions that has significant impact in unconventional reservoir development (e.g., completion design, production, and well spacing optimization), CO2 sequestration in geological formations (e.g., well and reservoir integrity), and engineered geothermal systems (e.g., …

Analysis Of The Effect Of Rate Of Fire On The Reproducibility Of Breech Face Impressions, Kayla Ann Trimble

Graduate Theses, Dissertations, and Problem Reports (ETD)

A major activity in firearms examination is the comparison of cartridge cases. In a crime scene where a firearm was discharged, it is very common to find cartridge cases littering the scene. Firearms examiners examine these cartridge cases along with test fired cartridge cases from the suspected firearm. They inspect the firearm to ensure that it is safe and in working condition before conducting test fires. These test fires are then compared to the submitted evidence. Comparison microscopes are used to visualize the impressions left on the cartridge case from the firing process. When comparing evidence to a known test …

A Comparative Analysis Of Coastdown Testing Methods From An Electric Drive Unit Engagement Perspective Using A Student-Designed Parallel Hybrid Electric Vehicle, Dawson Everett Dunnuck

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coastdown testing and road load determination are pivotal parts of the automotive design process. Vehicle manufacturers and independent companies perform and analyze road loads determined through a coastdown or similar method to determine a vehicle’s road load for modeling and EPA certification. For a traditional coastdown, the vehicle’s drivetrain must be disconnected through a clutch between the engine and the transmission while traveling at a high rate of speed to place the vehicle in neutral. This changes for hybrid and electric vehicles. Some hybrid, and most electric, vehicles delivered to customers do not have this clutch action to grant the …

Development Of A Mass Transfer Correction Factor In A Thermodynamic Model To Explain The Weathering Patterns Of Ignitable Liquids On Household Substrates At Elevated Temperatures, Max T. Denn

Graduate Theses, Dissertations, and Problem Reports (ETD)

To determine whether a questioned fire is the result of arson or not, forensic chemists will often attempt to extract and identify any ignitable liquid residues present in the fire debris. Forensic chemists use gas chromatography-mass spectrometry (GC-MS) to identify ignitable liquids based on similarities between chromatograms of fire debris extracts and those of reference ignitable liquids that have been evaporated (weathered) to different extents. Casework samples often appear to be relatively unweathered (e.g., 40-60%) and conventional wisdom is that the apparent lack of weathering is the result of entrapment; a process by which liquid residues are absorbed into the …

Understanding Emerging Travel Behavior In New York City, Md Amdad Hossen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Many large cities face significant challenges in providing safe, economical, equitable, reliable, and efficient mobility services. Moreover, mobility service options have been changing unprecedentedly due to the advent of emerging mobility services. Understanding the impacts of emerging mobility services (e.g., for-hire vehicles, bike sharing) on other travel modes (e.g., transit, non-motorized modes, personal car) and evolving travel behavior is critical to promote sustainable modes for urban residents and reduce auto-dependency. New York City (NYC) has been conducting annual mobility survey since 2017 to understand the emerging travel behavior and mode choice characteristics. This dataset presents a unique opportunity for conducting …

Parametric Energy Efficiency Impact Analysis For Industrial Process Heating Furnaces Using Measur, Prakash Singh Bisht

Graduate Theses, Dissertations, and Problem Reports (ETD)

Industrial process heating furnace operations consume considerable energy in the U.S. manufacturing sector, making it crucial to identify energy efficiency strategies due to the growing need to minimize energy usage and emissions. It is paramount that engineers and owners focus their resources on maintaining the parameters with the most significant impact on energy efficiency since it is not always feasible to oversee all the parameters. This study represents a comprehensive parametric analysis using MEASUR (Manufacturing Energy Assessment Software for Utility Reduction) to evaluate the impact of various key factors on energy efficiency for industrial process heating furnaces. The data for …

Scene Representation And Matching For Visual Localization In Hybrid Camera Scenarios, Marcela A. Mera Trujillo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Scene representation and matching are crucial steps in a variety of tasks ranging from 3D reconstruction to virtual/augmented/mixed reality applications, to robotics, and others. While approaches exist that tackle these tasks, they mostly overlook the issue of efficiency in the scene representation, which is fundamental in resource-constrained systems and for increasing computing speed. Also, they normally assume the use of projective cameras, while performance on systems based on other camera geometries remains suboptimal. This dissertation contributes with a new efficient scene representation method that dramatically reduces the number of 3D points. The approach sets up an optimization problem for the …

Accelerating Manufacturing Decisions Using Bayesian Optimization: An Optimization And Prediction Perspective, Taofeeq Olajire

Graduate Theses, Dissertations, and Problem Reports (ETD)

Manufacturing is a promising technique for producing complex and custom-made parts with a high degree of precision. It can also provide us with desired materials and products with specified properties. To achieve that, it is crucial to find out the optimum point of process parameters that have a significant impact on the properties and quality of the final product. Unfortunately, optimizing these parameters can be challenging due to the complex and nonlinear nature of the underlying process, which becomes more complicated when there are conflicting objectives, sometimes with multiple goals. Furthermore, experiments are usually costly, time-consuming, and require expensive materials, …

Losing My Religion: Contextualizing Continental Catholic Seminaries In The Elizabethan Reformation, 1558-1603, Cole Volman

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation examines the impact and influence of a portion of the early modern Jesuit seminary network within the narrative of the Counter Reformation. Following the rise of Elizabeth I, a significant number of Catholic recusants fled England to take up residence in a series of schools spread across Europe with the intention of completing their education and later contributing to the efforts to preserve Catholicism in their homeland. This dissertation argues that these schools played a significant role in the course of the “English Mission,” contributing to its conception, escalation, and eventual collapse in the late sixteenth century. Despite …

Enabling Cybersecure And Resilient Smart Distribution Grid With Edge Devices, Partha Sarathi Sarker

Graduate Theses, Dissertations, and Problem Reports (ETD)

The smart distribution grid achieves enhanced efficiency and flexibility through the utilization of advanced communication infrastructure, digital devices, and robust computation and control capabilities. Grid-edge devices including distributed energy resources (DERs) like solar photovoltaics (PV), battery storage systems, and intelligent electric loads like electric vehicles and smart appliances, are contributing to the growth of the smart distribution grid. This evolution is transforming the grid into a multifaceted network of interconnected devices and systems, enabling bidirectional data communication and power flows. However, these new layers of data integration and control in the smart grid introduce vulnerabilities to cyberattacks and accidental failures, …

Essays On Public Policy, Justin Craig Heflin

Graduate Theses, Dissertations, and Problem Reports (ETD)

The first chapter examines the impact of Red Flag Laws on homicide rates and suicide rates. Red Flag Laws seek to implement gun control measures by allowing the removal of firearms from individuals who pose a danger to themselves or others. Using a two-way fixed effects (TWFE) difference-in-differences (DiD) estimations, I demonstrate a negative and plausibly causal relationship between a state implementing a Red Flag Law and homicide rates. While there is also a reduction in suicide rates, I am unable to make causal claims. This study is the first to empirically examine Red Flag Laws, with an eye towards …

Study Of Capillary Channel Fiber Augmented Geobags For Accelerated Dewatering Of High Moisture Content Fine-Grained Acid Mine Drainage Precipitate, Luke William Daugherty

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study was to investigate techniques to accelerate filtration and dewatering of Acid Mine Drainage precipitate using geobags augmented with Capillary Chanel Fibers and internal lateral drainage structures. Laboratory and field research investigated increasing the total solids retention of Acid Mine Drainage precipitate in geobag storage systems. Current geobag design and field application of treated AMD precipitate exhibits limited filtration and drainage efficiency due to the high moisture content (2500%) polymer amended AMD flocculated solids. Capillary channel fibers (CCFs) are geosynthetic yarns formed with microgrooves and set into bundled arrangements capable of wicking water, via capillary action, …

Dietary Supplementation And Functional Foods: From Development To Clinical And Public Health Implications, Rachel Grace Newman

Graduate Theses, Dissertations, and Problem Reports (ETD)

A rigorous research process is the foundation for the development and ultimate recommendation for use of dietary supplements and functional foods. This dissertation uses three seemingly disparate studies to explore the diverse research methodologies used in dietary supplement and functional food development and use. The first study focuses on primary research on the development of microgreen lemon balm herbal tea, employing experimental methodologies to assess its nutritional and bioactive properties compared to adult lemon balm herbal tea. Results showed that adult lemon balm tea contained higher total phenolics, total flavonoids, rosmarinic acid, and antioxidant capacity than microgreen teas, with hot …

Computerized Trajectory Analysis For Firearms Examiners, Baillie E. Poulton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Trajectory determination is a very important part of understanding and reconstructing a shooting scene. Conditions for the scene vary for each crime committed, but the evidence left at the scene required to make a reconstruction remains similar. The job of the examiner is to collect the evidence left at the scene and use that evidence to establish what may have happened during the commission of the crime. There is also important information that an examiner may not be privy to, e.g., the firearm and cartridge used. In this case, the evidence that is present, and other gathered information can …

A Study Of Six Selected Piano Variations By Czerny, Hao Zhang

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research paper is focused on the piano variations by Carl Czerny (1791-1857), with discussion and analysis of six among his 180 sets of piano variations. These six sets of variations include: Les charmes de l'amitié (Charms of Friendship), Op. 55; Variations on a Theme from Oberon, Op. 134; Introduction and Variations on La muette de Portici, Op. 208; Variations brillantes sur un thème favori de l'opéra Hans Heiling de Henri Marschner, Op. 341; Variations on a Motif by Ch. L. Hoffmann, “Souvenir de Boieldieu,” Op. 352; and Eisenbahn Variationen (Variations on a Waltz by Strauss), Op. 431. These …

Localized Delivery Of Gm-Csf In The Regulation Of Breast Tumor Oxygen And Anti-Tumor Immunity Through Macrophages, Nicole E. Mihalik

Graduate Theses, Dissertations, and Problem Reports (ETD)

GM-CSF has been employed as an adjuvant to cancer immunotherapies in solid tumors due to its ability to drive immune stimulatory macrophages and other myeloid cells that promote anti-tumor responses. However, GM-CSF does not always exert immune stimulatory effects on myeloid cells, and sometimes even drives immune suppressive phenotypes. GM-CSF effects on myeloid cells and the tumor microenvironment (TME) appear to vary across dosages and even cancer types. However, an optimal dosing regimen for GM-CSF has yet to be determined to-date, and this is further complicated by the fact that GM-CSF is often administered via oncolytic viruses or tumor vaccines …

Component Optimization Of A Parallel P4 Hybrid Electric Vehicle Utilizing An Equivalent Consumption Minimization Strategy, Holden Ryan Fraser

Graduate Theses, Dissertations, and Problem Reports (ETD)

Advancements in battery and electric motor technology have driven the development of hybrid electric vehicles to improve fuel economy. Hybrid electric vehicles can utilize an internal combustion engine and an electric motor in many configurations, requiring the development of advanced energy management strategies for a range of component configurations. The Equivalent Consumption Minimization Strategy (ECMS) is an advanced energy management strategy that can be calculated in-vehicle in real-time operation. This energy management strategy uses an equivalence factor to equate electrical to mechanical power when performing the torque split determination between the internal combustion engine and electric motor. This equivalence factor …

Advancing Assessments Of Climate Change Vulnerability Of West Virginia Watersheds, Joseph T. Molina

Graduate Theses, Dissertations, and Problem Reports (ETD)

As climate change is becoming increasingly recognized as a threat to aquatic ecosystems, climate adaptation planning, in both the long- and short-term, is becoming more common in natural resource management. There is a need within conservation agencies to develop methodologies and assessments that support adaptation planning to efficiently disperse conservation dollars and effectively strengthen ecological and community resilience as climate changes continue. My thesis aims to provide West Virginia natural resources managers with climate vulnerability assessments that can be used to determine where and how conservation efforts should be administered. Additionally, I demonstrate a methodology that can be built upon …

An Empirical Analysis Of Approximation Algorithms For The Unweighted Tree Augmentation Problem, Jacob Thomas Restanio

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis, we perform an experimental study of approximation algorithms for the tree augmentation problem (TAP). TAP is a fundamental problem in network design. The goal of TAP is to add the minimum number of edges from a given edge set to a tree so that it becomes 2-edge connected. Formally, given a tree T = (V, E), where V denotes the set of vertices and E denotes the set of edges in the tree, and a set of edges (or links) L ⊆ V × V disjoint from E, the objective is to find a set of edges …

Design And Validation Of An Aerodynamic System For A Formula Sae® Vehicle Using Vehicle Dynamic Simulation And Experimentation, Evan S. Cole

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis presents the design, simulation, and experimental validation for the aerodynamic system for a Formula SAE® vehicle. The Society of Automotive Engineers ® (SAE) hosts a collegiate competition annually called Formula SAE® where students design, fabricate, and test a small “formula style” vehicle. The vehicle performs in relatively slow maneuvers, around different courses and tests to evaluate the vehicle’s overall performance. Over the years, collegiate teams have put significant research into the design and manufacturing of the aerodynamics of these vehicles. In order to justify this undertaking for future teams at West Virginia University’s Formula SAE® program, a comprehensive …

The Uncertain Future Of Landscapes Subjected To Mountaintop Removal Mining, Samuel James Bower

Graduate Theses, Dissertations, and Problem Reports (ETD)

Increased erosion following human land disturbance is a global issue for ecosystem health and land management. Mountaintop removal (MTR) mining – a type of surface mining predominately found in the Central Appalachian Coalfields region – is one of the most significant examples of human perturbation to a natural landscape. A post-MTR landscape, when compared to its natural state, has significantly different erosive potential due to the rearrangement of topography from mining and reclamation practices. Removal of vegetation and alterations to soil further influence erosion by raising the effective erodibility of substrate subjected to MTR. We quantify the changes in erosion …

Diversification Of Ergot Alkaloid Biosynthesis In Natural And Engineered Fungi, Kyle Austin Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ergot alkaloids are a complex family of tryptophan-derived mycotoxins produced by a diverse range of fungi that occupy a wide variety of ecological niches including soil saprotrophs, plant endophytes, pathogens of plants or insects, and opportunistic pathogens of humans and other mammals. Ergot alkaloids are a similarly diverse family of chemicals that elicit a variety of pharmacological activities in animals due to their resemblance to neurotransmitters and high binding affinity for neurological receptors, including those that bind adrenaline, dopamine, and 5-hydroxytryptamine receptors. These structural similarities allow us to create medicines aimed at treating a range of neurological diseases and disorders …

Evaluation Of Emerging Screening Technologies For The On-Site Detection And Identification Of Methamphetamine And Its Precursors In Simulated Clandestine Lab Operations, Alexis Nicole Wilcox

Graduate Theses, Dissertations, and Problem Reports (ETD)

Stimulant drugs comprise one of the top drug categories abused in the United States. Due to its accessibility, low price, and manufacturing simplicity, methamphetamine is frequently placed within the top 10 seized drugs in the country. As of March 2023, methamphetamine is the most seized controlled substance in the United States, with 34,291 kg. In 2022, the United States seized over 79,000 kg of methamphetamine. One reason for the proliferation of methamphetamine is related to the production itself, which does not require large warehouses but can be manufactured in houses using relatively accessible materials and small containers. When a clandestine …

Investigating The Effects Of Flotation Restricted Environment Stimulation Therapy On Neural Networks In Chronic Pain Patients Via Functional Magnetic Resonance Imaging And Other Modalities, Tyler Austin Mcgaughey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic lower back pain (CLBP) is one of the leading causes of disability worldwide, with an estimated direct cost of over 600 billion dollars in the US alone. CLBP profoundly impacts the patient, their support team, and the healthcare system. Widespread changes to the patient's well-being, including mental health, are seen in CLBP and contribute to a downward spiral that often leads to disability. Chronic pain is poorly understood and is difficult to treat because of its subjective nature. Recent improvements in pain assessment in the clinic and in biomedical research have had a profoundly impacted the field. More than …

Program Evaluation Of A Type 1 Diabetes Transition Process For Emerging Adults, Anna J. Shashura

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: To evaluate a structured transition program, Preparing Emerging Adults with Knowledge and Skills (PEAKS), for pediatric patients with type 1 diabetes (T1D) in an outpatient pediatric endocrinology center.

Design and Methods: Program evaluation was completed following the Centers for Disease Control and Prevention Framework for Program Evaluation in Public Health, focusing on implementation adherence, glycosylated hemoglobin (HbA1C), and provider satisfaction for the first three visits of the PEAKS program. Satisfaction was assessed using the Got Transition Sample Health Care Transition Feedback Survey for Clinicians. Implementation adherence and HbA1C were gathered using retrospective chart review.

Results: Less than half …

Finite Element Modeling And Analysis Of Breech Face Impressions, James A. Hamilton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Finite element analysis (FEA) is a technique which has not been widely used in Forensic Science in general and firearms examination in particular. The general utility of FEA was assessed by the simulation of scenarios commonly encountered during the investigation of firearm related crimes. As a test, simulations included the perforation of a windshield and sheet metal with a 9 mm projectile, the development of pseudo subclass characteristics during the manufacturing of a breech face, and the impact of a projectile with another projectile in air and with a solid body. Results from the simulations were compared to projectiles and …

Elucidating Mechanisms Of Proteasome Modulation By Small Molecules To Treat Neurodegenerative Diseases And Cancer, Janelle Joo Yee Chuah

Graduate Theses, Dissertations, and Problem Reports (ETD)

Maintaining protein homeostasis, or proteostasis, is crucial for cellular function, and protein degradation through the proteasome plays a pivotal role in this process. Dysregulation of the proteasome can lead to proteostasis collapse and has been linked to the development of neurodegenerative diseases and cancers. Neurodegenerative diseases often exhibit proteasome impairment, whereas proteasome upregulation is frequently observed in cancer. Although the use of proteasome inhibitors as a pharmaceutical approach has shown success in certain cancers, it has yet to demonstrate efficacy in neurodegenerative diseases due to the absence of drug-like small molecules capable of effectively reversing proteasome impairment and/or activating the …