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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Selected Piano Etudes From The Mid-20th To 21st Centuries: A Catalogue, Min Ji Baek Jan 2024

Selected Piano Etudes From The Mid-20th To 21st Centuries: A Catalogue, Min Ji Baek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Etudes, which initially appeared in the seventeenth century as small collections of exercises, have evolved into significant concert pieces, showcasing the development of virtuosity over time. This study compiles a selected catalog of piano etudes from the mid-20th century to the 21st century, accompanied by brief biographies of each composer. Beginning with a historical overview of piano etudes, this paper catalogs etudes by 50 composers, divided into two chapters that respectively present etudes from the 1940s–1980s and the 1980s–2020s, listed alphabetically by the composer's last name. The final chapter provides a concise summary of the catalogue’s contents, highlighting its potential …


Modeling The Dynamics Of Radiation Belt Electrons And Ring Current Protons, Xingzhi Lyu Jan 2024

Modeling The Dynamics Of Radiation Belt Electrons And Ring Current Protons, Xingzhi Lyu

Graduate Theses, Dissertations, and Problem Reports (ETD)

Earth’s inner magnetosphere is a highly dynamic region with various charged particle populations and current systems. The radiation belts, composed of relativistic electrons and protons, is an environment that can pose significant risks to both spacecraft and humans in space; while the fluctuations of ring current, an electric current flowing around the earth consisting of energetic electrons and ions, can lead to severe disruptions in ground-based electrical systems. In this dissertation, we first modeled the long-term evolution of ring current protons based on the measurements of Van Allen Probes. By implementing a 1D radial diffusion model with charge exchange loss, …


Machine Learning And Rna Bioinformatics, Jason Rafe Miller Jan 2024

Machine Learning And Rna Bioinformatics, Jason Rafe Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

The applied science of bioinformatics encompasses computational analysis of molecular biology data. Advances in genomics and DNA sequencing technology have enabled computational analysis of ribonucleic acids (RNAs), which play diverse and critical roles in most cells. To assist the study of human RNA, we trained machine learning models on RNA nucleotide sequences, devoid of domain knowledge. We built models that distinguish long non-coding lncRNA from protein-coding mRNA, and models that predict the cytoplasmic vs. nuclear preferences of lncRNAs. In a review of published lncRNA subcellular localization classifiers, we show that the commonly used validation protocol generates optimistic performance measures, and …


Exploring Crystal Polymorphism In Additive-Assisted Chemical Vapor-Deposited Transition Metal Chalcogenides And Oxides, Lawrence Kirimi Mubwika Jan 2024

Exploring Crystal Polymorphism In Additive-Assisted Chemical Vapor-Deposited Transition Metal Chalcogenides And Oxides, Lawrence Kirimi Mubwika

Graduate Theses, Dissertations, and Problem Reports (ETD)

Crystal polymorphism is a phenomenon in which compounds with the same chemical formula can be crystallized into different crystal structures. This phenomenon can be observed in elemental materials, such as diamond and graphite, as well as in compounds, such as the trigonal (1H) or octahedral (1T) prismatic MoS2. Crystals can also exhibit polytypism by stacking different polymorphs in a certain order, with the stacking sequence determining the variation between polytypes. Although all polymorphs and polytypes have the same chemical composition, each polymorph and polytype possesses unique electronic and physical properties.

This study explores the additive-assisted chemical vapor deposition …


Reformed-Based Approaches To The Teaching And Learning Of Science, Sahar Vali Jan 2024

Reformed-Based Approaches To The Teaching And Learning Of Science, Sahar Vali

Graduate Theses, Dissertations, and Problem Reports (ETD)

This qualitative practice-based study explores the efficacy of reformed-based science teaching approaches in fostering meaningful student engagement within elementary science classrooms, framed within the science-as-practice paradigm. Utilizing three theoretical frameworks, the Next Generation Science Standards (NGSS) and Ambitious Science Teaching (AST), and the Teacher Noticing, this research investigates how these frameworks influence student engagement in scientific disciplinary practices. The study draws on data from an NSF-funded project on teacher noticing in fifth-grade classrooms in West Virginia. Through a practice-based research approach, the relationship between teachers’ pedagogical practices and student engagement in science and engineering practices as outlined by NGSS and …


Contracture Management For Acute Burn Injury Patients, Brianna Paige Pestrosky Jan 2024

Contracture Management For Acute Burn Injury Patients, Brianna Paige Pestrosky

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: The Occupational Therapists working within the burn unit at West Penn Hospital assess and treat patients utilizing the biomechanical approach FOR, as well as the support from MOHO and PEOP. The patients seen within the burn unit encompass a variety of injuries and occupational deficits that require an individualized and holistic approach to care.

Purpose: The purpose of the contracture management project is to provide an interdisciplinary approach to improve carryover and patient care within and out of the hospital.

Theoretical framework: The contracture management project is guided using the biomechanical frame of reference as well as supporting constructs …


Data-Driven Approaches For Achieving Carbon Neutrality: Predictive Models For Reducing Co2 Emissions And Enhancing Industrial Sustainability, Farzana Islam Jan 2024

Data-Driven Approaches For Achieving Carbon Neutrality: Predictive Models For Reducing Co2 Emissions And Enhancing Industrial Sustainability, Farzana Islam

Graduate Theses, Dissertations, and Problem Reports (ETD)

In response to the escalating challenges posed by climate change and industrial inefficiency, this thesis presents a comprehensive investigation aimed at advancing the predictive modeling of global CO2 emissions and enhancing operational efficiency in steel manufacturing through Electric Arc Furnace (EAF) temperature optimization. Leveraging a rich dataset sourced from the World Development Indicators database alongside a meticulously curated dataset specific to EAF operations, our study applies an innovative blend of econometric and machine learning techniques, including Pooled Ordinary Least Squares (Pooled OLS), Random Effects (RE), Fixed Effects (FE), and Seasonal Autoregressive Integrated Moving Average with Exogenous Variables (SARIMAX) models. The …


Developmentally Appropriate Care In The Neonatal Intensive Care Unit (Nicu), Ashten Cenkus Jan 2024

Developmentally Appropriate Care In The Neonatal Intensive Care Unit (Nicu), Ashten Cenkus

Graduate Theses, Dissertations, and Problem Reports (ETD)

As specialized healthcare professionals educated in developmental care, occupational therapy practitioners (OTPs) have a role in educating, coaching, and assessing the needs of infants, their families, and the staff in the NICU. These high-risk and medically fragile infants require specialized care that considers the incorporation of neurodevelopment, neurobehavioral regulation, sensory stimulation, and motor development through supportive and appropriate interventions. A project addressing these needs across 14 weeks was implemented as part of an Occupational Therapy Doctoral (OTD) capstone experience at WVU Medicine Children’s in Morgantown, West Virginia. This project examined the results of the NICU staff's confidence, knowledge, and awareness …


A Multi-Wavelength Determination Of The Total Luminosity And Star Formation Rate Of The Milky Way, Joshua L. Mascoop Jan 2024

A Multi-Wavelength Determination Of The Total Luminosity And Star Formation Rate Of The Milky Way, Joshua L. Mascoop

Graduate Theses, Dissertations, and Problem Reports (ETD)

The star formation rate (SFR) of the Milky Way is poorly understood in comparison to the SFR of other galaxies. In order to better find the Galaxy's place in the universe, it is imperative to understand the star formation activity occurring within it. We characterize the Galactic \hii\ region luminosity function (LF) at multiple infrared and radio wavelengths using a sample of 797 first Galactic quadrant \hii regions compiled from the WISE Catalog of Galactic \hii Regions. This sample is statistically complete for all regions powered by single stars of type O9.5V and earlier.

We find that neither a single …


Assessment Of Instrument Exploring Underwear Preferences Of Incontinent Geriatric Women In Assisted Living, Cassandra M. Stewart Jan 2024

Assessment Of Instrument Exploring Underwear Preferences Of Incontinent Geriatric Women In Assisted Living, Cassandra M. Stewart

Graduate Theses, Dissertations, and Problem Reports (ETD)

Urinary incontinence is a urologic condition commonly occurring in geriatric individuals and often results in disability. This affects not only physical functioning, but also psychological and emotional implications. Prior research focused on prevention and using smart technology to improve the current products available to help manage urinary incontinence. Little research has been completed to examine the preferences of geriatric individuals and assess what they are looking for in incontinence products. The purpose of the study was to create an instrument to assess the individual preferences of older adults for these products in a community living environment. Research questions included: (1) …


Advances In Machine Learning Aided Seismic Interpretation And Inversion For Subsurface Characterization, Tobi Micheal Ore Jan 2024

Advances In Machine Learning Aided Seismic Interpretation And Inversion For Subsurface Characterization, Tobi Micheal Ore

Graduate Theses, Dissertations, and Problem Reports (ETD)

Geophysical data are used to “remotely sense” the subsurface to illuminate structures, stratigraphy, and features that are of interest in the exploration for energy, suitable storage for carbon dioxide, geothermal development, and environmental considerations. The interpretations of these data typically are regarded as partially an art, as it depends on the experience of the interpreter. This is further exacerbated with the big data era as this data is large and takes several days, even longer, to manually interpret. To bridge this gap of speed and subjective bias, machine learning has been successfully applied to automate the geophysical interpretation process. This …


Examining Invalid Brief Child Abuse Potential Inventory Profiles Within A Randomized Controlled Trial For Toddler-Aged Children And Their Parents, Lindsay Rebecca Druskin Jan 2024

Examining Invalid Brief Child Abuse Potential Inventory Profiles Within A Randomized Controlled Trial For Toddler-Aged Children And Their Parents, Lindsay Rebecca Druskin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Child abuse is a significant public health concern that impacts children worldwide. Efforts to connect at-risk parents with prevention and intervention programs require the use of high-quality measures that evaluate child abuse potential. Researchers frequently use the Child Abuse Potential Inventory (Milner, 1986) and the Brief Child Abuse Potential Inventory (BCAP; Ondersma et al., 2005) which contain Validity indices that evaluate response patterns such as social desirability responding. The measure developers recommended that abuse risk scores from invalid profiles be disregarded in clinical and research settings; however, little is known about factors that may relate to invalid responses and whether …


S(+)-Propylnorapomorphine Hydrochloride Alters Mutant Huntingtin Aggregation And Membrane Interactions, Gabriella M. Pettipas Jan 2024

S(+)-Propylnorapomorphine Hydrochloride Alters Mutant Huntingtin Aggregation And Membrane Interactions, Gabriella M. Pettipas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder resulting from an abnormally long CAG repeat in the huntingtin gene. This results in an expanded polyglutamine (polyQ) domain in the huntingtin protein (htt) that directly leads to self-assembly of huntingtin (htt) into a variety of aggregate species that underlie cellular toxicity. Interaction of protein aggregates with a variety of lipid membranes has been linked to disease pathology. Here, the ability of a small molecule S(+)-propylnorapomorphine (NM) hydrochloride to modulate htt-exon1(46Q) aggregation and interactions with lipid membranes was determined. ThT assays were performed to quantify fibril formation of htt in the …


Formulation, Sensory Evaluation, And Physicochemical Assessment Of And Consumer Behavior Toward Novel Energy Bars, Ian Phillip Israelsen Jan 2024

Formulation, Sensory Evaluation, And Physicochemical Assessment Of And Consumer Behavior Toward Novel Energy Bars, Ian Phillip Israelsen

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objectives of this study were to 1) formulate a novel energy bar containing significant macronutrients and calories per serving with favorable ratings from consumers; 2) analyze responses to a consumer preference survey and sensory evaluation of novel energy bars compared to a commercially available energy bar. For the first study, fourteen iterations of an energy bar were synthesized with differing protein sources (whey, soy, pea, hemp), and characteristic variations (nougat, chocolate truffle, peanut butter, double-date caramel). A shortbread base, date caramel, and chocolate coating were included in every bar. Sensory evaluations determined that the most liked variation overall was …


Kinetic Study Of Oh Radical Reactions With Cyclopentenone Derivatives, Patrick Kipkoech Rutto Jan 2024

Kinetic Study Of Oh Radical Reactions With Cyclopentenone Derivatives, Patrick Kipkoech Rutto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Conjugated a, b-unsaturated carbonyl compounds like cyclopentenone play a significant role in various environmental processes. These compounds are formed in combustion and Earth’s atmosphere from the oxidation of cyclic ketones such as cyclopentanone. Once formed under oxidative conditions, cyclopentenone may react with presence of free radicals like OH in the atmosphere molecules to form vinoxy type resonantly stabilized radicals. The presence of free radicals species like OH, O2 in the atmosphere can react with these molecules resulting into intermediate products that dissociate to give final products. Experimental and theoretical investigations in the reactions of cyclopentenone derivatives with these small free …


Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi Jan 2024

Estimating Home Range Size And Density Of White-Tailed Deer (Odocoileus Virginianus) In West Virginia, Sarah M. Pesi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Big game hunting is an important source of revenue and recreation in the United States. Of big game species, white-tailed deer (Odocileus virginianus) are the most heavily pursued. White-tailed deer are a widespread generalist species, capable of existing at high densities. Hunting is often used as the primary method of managing deer populations, particularly in the eastern United States, where there is a lack of large predators. When populations reach high densities, there can be negative effects on the environment and conflicts with humans. Managers must consider both creating adequate hunting opportunities and reducing negative impacts when managing …


The Impact Of Low-Skew On The Ultimate Capacity Of Press-Brake-Formed Tub Girders, Madison Lynn Morgan Jan 2024

The Impact Of Low-Skew On The Ultimate Capacity Of Press-Brake-Formed Tub Girders, Madison Lynn Morgan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The development of press-brake-formed tub girders (PBFTGs) has offered innovative solutions for short-span steel bridge applications and helps meet the demand for rapid infrastructure replacement solutions. The Short Span Steel Bridge Alliance (SSSBA) comprises bridge and buried soil structure industry leaders who aim to provide essential educational information to bridge and highway professionals on the design and construction of short-span steel bridge installations (SSSBA, 2020). The American Association of State and Highway Transportation Officials (AASHTO) provides design standards, specifications, and guidance for the analysis and construction of PBFTGs. Currently, the AASHTO Load Resistance and Factor Design Bridge Design Specifications (AASHTO …


Making Something Out Of Nothing: Immobility As An Operant, KaʻAla K. Bajo Jan 2024

Making Something Out Of Nothing: Immobility As An Operant, KaʻAla K. Bajo

Graduate Theses, Dissertations, and Problem Reports (ETD)

The tradition of research in the experimental analysis of behavior generally emphasizes the analysis of overt, discrete responses such as lever presses or key pecks. Reflecting this emphasis, definitions of behavior involve the observable action or movement of an organism through space. Although continuous responses involving little to no movement, such as “holding still” or “immobility”, fall outside these definitions, immobility is a form of continuous, operant responding that can be learned and experimentally controlled. Three experiments were conducted to investigate parameters surrounding immobility as an operant. In Experiment 1, immobility in the form of platform-standing bouts was shaped and …


Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey Jan 2024

Electronic Symptom Management Using Pros In A Rural, Appalachian Medical Oncologic Population, Andrea Ray Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Systemic chemotherapy is a cornerstone of cancer treatment, but it often leads to significant side effects, which may impact patients' quality of life and lead to increased acute healthcare utilization. Although patients are typically informed of potential symptoms and advised to seek care as needed, many struggle to understand and manage symptoms effectively. Patient-reported outcomes (PROs) have been shown to improve symptom monitoring, decrease symptom burden, and reduce emergency department visits and hospital admissions. Electronic patient-reported outcomes (ePROs), in particular, offer timely and accessible symptom tracking, though their effectiveness has largely been evaluated within urban clinical trial settings and …


A Hyperbolic Relaxation Solver For Numerical Relativity, Thiago Assumpcao Jan 2024

A Hyperbolic Relaxation Solver For Numerical Relativity, Thiago Assumpcao

Graduate Theses, Dissertations, and Problem Reports (ETD)

Numerical relativity (NR) simulations are essential for self-consistently modeling compact binary mergers, whose observations form the heart of gravitational-wave science. Stable NR simulations are the result of mathematical and computational breakthroughs spanning several decades: early attempts to numerically solve the two-body problem in General Relativity (GR) date back to the 1960s, while the first successful black-hole binary merger simulations were performed in 2005 with the generalized harmonic coordinates, and in 2006 using the moving-puncture gauge.

Today, NR continues to drive progress in gravity research, with ongoing efforts focused on increasing physical realism in simulations containing matter, exploring alternative theories of …


Evaluating The Efficacy Of The Archaeal Proteasome To Alleviate Protein-Misfolding Retinopathy, Celine Brooks Jan 2024

Evaluating The Efficacy Of The Archaeal Proteasome To Alleviate Protein-Misfolding Retinopathy, Celine Brooks

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nearly all neurodegenerative diseases (NDs) and some eye diseases are characterized by the presence of misfolded and aggregated proteins. The ubiquitin proteasome system (UPS) is responsible for degrading the majority of proteins including misfolded and aggregated proteins. However, in NDs the performance of the UPS is impaired, and this impairment partially comes from these protein aggregates inhibiting the proteasome. This inhibition leads to an accumulation of protein aggregates, more proteasomal inhibition, and fewer chaperones for newly synthesized proteins, triggering a collapse in proteostasis, which is thought to contribute to the pathogenesis of NDs. Consequently, stimulating proteasome function is being investigated …


Policy Dynamics In Young Democracies: Attention, Electoral Change, And Responsiveness In Ghana And South Africa, Christiana Bugri Jan 2024

Policy Dynamics In Young Democracies: Attention, Electoral Change, And Responsiveness In Ghana And South Africa, Christiana Bugri

Graduate Theses, Dissertations, and Problem Reports (ETD)

My dissertation is a collection of three essays that assess the nature of government attention in young democracies. Theories of the policy process focus on policy dynamics in Western democracies with little application to non-Western democracies. This dissertation bridges this gap by studying policy dynamics in the neopatrimonial democracies of Ghana and South Africa. The dissertation sheds light on how the unique features of young democracies (centralization, clientelism, and powerful executives) shape government attention, responsiveness to public opinion, and the importance of elections in policy change. The first essay examines the dynamics of government attention and how the neopatrimonial nature …


Laser Deposition Additive Manufacturing Of Multi-Material And Metal-Ceramic Composite Structures, Manikanta Grandhi Jan 2024

Laser Deposition Additive Manufacturing Of Multi-Material And Metal-Ceramic Composite Structures, Manikanta Grandhi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increasing performance requirements of modern industrial systems, coupled with the imperative for decarbonization, necessitate a fundamental rethinking of metallic component design and manufacturing. Traditional materials, with their inherent limitations in property optimization, susceptibility to degradation, and weight constraints, are proving insufficient. Multi-material joining offers a potential solution, enabling designers to strategically integrate diverse materials with specific, tailored properties into single component. Functionally graded materials (FGMs) and oxide dispersion strengthened (ODS) materials are prime examples of this approach, delivering substantial improvements in wear resistance, thermal regulation, high-temperature resilience, and overall weight efficiency. However, conventional manufacturing approaches further exacerbate the limitations …


Triggered Online System Re-Identification Applied To Model Predictive Control Using Gaussian Processes, Daniel Augusto Kestering Jan 2024

Triggered Online System Re-Identification Applied To Model Predictive Control Using Gaussian Processes, Daniel Augusto Kestering

Graduate Theses, Dissertations, and Problem Reports (ETD)

Safety, product quality, enhanced performance, and increased profit all depend on the control of chemical and energy processes. However, operational issues can lead to control challenges, especially when processes are subject to disturbances during their operation. Process control methods work best when processes operate close to their designed operat- ing conditions, but lack of performance or other issues may occur when the process is far from such conditions. To overcome these challenges, in this dissertation, online model re- identification is proposed for Model Predictive Control (MPC). This involves reassessing the predictive model of an advanced controller, namely MPC, when re-identification …


Piano Wisdom From Two Great Masters: Heinrich Neuhaus And Walter Gieseking, Xiaohan Hu Jan 2024

Piano Wisdom From Two Great Masters: Heinrich Neuhaus And Walter Gieseking, Xiaohan Hu

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the pedagogical insights and piano techniques of Heinrich Neuhaus (1888-1964) and Walter Gieseking (1895-1956), two iconic figures in 20th-century piano performance and education. Through a detailed analysis of their writings and teaching methods, the research highlights their shared focus on the foundational principles of piano technique, as well as their unique contributions to interpretation and musical expression.

Neuhaus’s The Art of Piano Playing provides an in-depth discussion on the importance of artistic imagery, posture, sound production, and emotional depth in performance. Gieseking, along with his former teacher Karl Leimer, emphasizes ear training, mental visualization, and technical precision …


X-Ray Absorption And Related Studies In Superconducting Devices And Magnetic Thin Films, Ghadendra Bahadur Bhandari Jan 2024

X-Ray Absorption And Related Studies In Superconducting Devices And Magnetic Thin Films, Ghadendra Bahadur Bhandari

Graduate Theses, Dissertations, and Problem Reports (ETD)

Superconducting and magnetic thin films are commonly used in sensors for analytical detectors, especially those that operate at very low temperatures, often below 1 Kelvin. These highly sensitive detectors, capable of functioning across a broad range of wavelengths, have garnered significant interest in scientific research. The focus of this thesis is to address a material challenge associated with an emerging technology known as microwave kinetic inductance detectors (MKIDs). The research involves the study of Al/Si and Al-Mn/Si-based thin films, as well as an investigation into the magnetic properties of LaMnO₃ thin films. LaMnO₃, a perovskite thin film that plays a …


Conformational Investigation Of Biopolymers Through Molecular Dynamics (Md) Simulations And In-Droplet Hdx-Ms Utilizing Cvssi, Samira Hajian Foroushani Jan 2024

Conformational Investigation Of Biopolymers Through Molecular Dynamics (Md) Simulations And In-Droplet Hdx-Ms Utilizing Cvssi, Samira Hajian Foroushani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over the last two decades, mass spectrometry (MS) has received significant interest in biological study platforms, especially in the areas of proteomics and metabolomics. With the development of soft ionization methods like electrospray ionization (ESI), mass spectrometry has emerged as a potent method for directly characterizing proteins in their native state. The recent invention of capillary vibrating sharp-edge spray ionization has opened new avenues for the study of biopolymer native structure including the usage of droplet charge tuning and in-droplet hydrogen-deuterium exchange (HDX) labeling. With this new technique comes the opportunity to study biopolymer ion structure preservation with molecular dynamics …


A Floquet Solver For Time Periodic Open Quantum Systems, Fenton Ross Clawson Jan 2024

A Floquet Solver For Time Periodic Open Quantum Systems, Fenton Ross Clawson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Computational physics has been a backbone of experimental and theoretical physics since the 1940’s, when the first nuclear bomb and ballistic simulations were per- formed at Los Alamos Laboratory. Nowadays, however, simulation of open quan- tum systems has been formalized into coding packages and user-friendly functions, such as QuTiP or Qiskit, which allow users to simulate these systems without hav- ing the in-depth knowledge required to build the computational backbone from the ground-up. With the shift in modern quantum physics towards the realization of quantum computation, a strong computational background is still necessary to lend validity to theoretical results and …


Α-Hydroxy C–H Functionalization Of Alcohols Via Boronic Acid, Hat, Photoredox Triad Catalytic System, Seth Christopher Cowan Jan 2024

Α-Hydroxy C–H Functionalization Of Alcohols Via Boronic Acid, Hat, Photoredox Triad Catalytic System, Seth Christopher Cowan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the research that I have conducted in my time at West Virginia University. Most of my work has focused on the development of methods and studies to further understand the α-OH C–H functionalization of alcohols. This work involves a system of catalysts including photocatalysts, HAT catalysts, and boronic acid catalysts. Chapter 1 highlights a background for each of these areas. Photoredox catalysis has been an increasing area of chemistry over the past two decades as this technique can be used to design conditions to form new bonds in a selective manner through the utilization of light energy. …


The Role Of Uric Acid In Metabolic Abnormalities Of Obesity, Andrew P. Giromini Jan 2024

The Role Of Uric Acid In Metabolic Abnormalities Of Obesity, Andrew P. Giromini

Graduate Theses, Dissertations, and Problem Reports (ETD)

Uric acid (UA) is the single most tightly associated metabolite for obesity and type 2 diabetes. While the field varies on whether UA is causative or correlative of the metabolic dysfunction allied to obesity, these studies use different diets and animal models to make these claims. It is the goal of this dissertation to compare different diets commonly used in this research to delve deeper into the data and determine which diets induce elevated circulating UA levels as well as which diets also induce metabolic dysfunction. Early chapters of this dissertation examine the comparison of high fructose consumption, both in …