Digital Commons Network^™

A Multidisciplinary Approach To Identify Postoperative Delirium In Geriatric Patients Using A Brain Health Screening Tool, Ashlyn Mccartney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Postoperative delirium (POD) is a common occurrence, effecting nearly 61% of the surgical population recovering from anesthesia. POD increases risk of morbidity and mortality leading to prolonged hospital length of stay by 0.8 to 7.3 days and increased costs by $1,551 to $23,698 (Masharaf et al., 2022; Sethi, 2021). An academic medical center in northern West Virginia (WV) lacks a structured practice/protocol to identify high risk patients and assess POD. An evidence-based solution was developed based on the PICO question: Does a multidisciplinary approach to perianesthetic care utilizing a brain health screening tool, compared to lack of a screening tool, …

Multidisciplinary Approach To Injury Rehabilitation: The D1 College Athlete Perspective, Lindsey Leatherman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sport injuries continue to be unavoidable disruptions in student-athletes’ athletic careers with over 200,000 injuries estimated to be reported each year in college sport (Kerr et al., 2015). Researchers continue to emphasize the importance of an interprofessional approach to rehabilitation to help athletes manage the adverse psychological and emotional reactions to injury (Appaneal et al., 2009; Gervis et al., 2020; Putukian, 2016). The purpose of this study was to extend and replicate the research of Clement and Arvinen-Barrow (2021) by incorporating perspectives of Division I US student-athletes. The current study describes 321 NCAA Division I collegiate athletes’ experiences of receiving …

Investigating The Role Of Spinal Motoneuron Organization In Human Motor Control, Rachel I. Taitano

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mechanisms of voluntary motor control are complex and require inputs via cortical centers, peripheral sensory systems, and spinal inputs such as central pattern generators. It is hypothesized that control is simplified via utilization of motor primitives, which may rely on structures within the spinal cord, however this remains unknown in both human and non-human primates. The goal of this dissertation is to characterize muscle activity in the upper extremity in relation to the corresponding anatomical organization of spinal motoneurons to provide insight into how primitives are both organized and activated to produce movement.

The first aim of this work was …

Making Home Here: Young Refugee-Migrant Women And The Work Of Emplacement In A Rural Appalachian Town, Valentina Muraleedharan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation centres young refugee-migrant women’s voices, perspectives, concerns, and actions living in a small, rural Appalachian town called Easton, exploring their social, cultural, and economic experiences. It infers that through their critical participation in family life and labour in making a home in a new place, young refugee-migrant women’s relations to family and place impact how they negotiate their aspirations and future im/mobilities to create pathways to emplacement. Emplacement is an ongoing process that hinges on the efforts of individuals, families, and communities to find a way in a new place by giving meaning to their surroundings. This research …

Project Quiet: A Quality Improvement Initiative To Reduce Noise Pollution During Anesthesia Induction And Emergence, James Christopher Woods

Graduate Theses, Dissertations, and Problem Reports (ETD)

Problem: Excessive intraoperative noise puts anesthesia providers at risk for errors that could negatively impact patient morbidity and mortality. Distractions from excessive noise experienced during the “critical phases” of anesthesia present a risk to patient safety and need to be reduced or eliminated. Anecdotally, reports from anesthesia staff at a large academic medical center confirmed that noise pollution during induction and emergence significantly impacted the performance of critical anesthesia tasks. Objective: The goal of this quality improvement (QI) project was to implement a series of interventions designed to reduce noise pollution during induction and emergence, and to reduce …

Commonplace, Heather Lepp

Graduate Theses, Dissertations, and Problem Reports (ETD)

The paper as follows will explore the conceptual and aesthetic decisions behind my MFA thesis exhibition titled Commonplace. It will outline my personal history, philosophical outlook, and conceptual framework behind making utilitarian pottery to elevate daily experiences. It will also investigate my individual exploration into beauty in relation to the process of making my work. Formal considerations such as visual, tactile, and functional aspects of the work will be addressed. Sharing, gathering, and preparing food influences me as a maker, and being attentive inspires me to create utilitarian wares that are used as cherished tools to enrich daily life.

Between Wages And Wellbeing: Examining The Role Of Employers In Increasing Covid-19 Vaccine Uptake In The State Of West Virginia, Nathaniel Udoh Godwin

Graduate Theses, Dissertations, and Problem Reports (ETD)

The novel coronavirus disease 2019 (COVID-19) stretched public health systems globally, with millions of cases confirmed across all continents of the world. The United States health systems struggled as the country grappled with emerging variants of the virus, differing levels of vaccine acceptance, misinformation, and disparity in health outcomes. As COVID-19 vaccines emerged, the U.S. Government sought to bolster uptake through myriad measures, including announcing vaccine requirements for federal employees, which was met with mixed reactions. Accordingly, some employers and businesses adopted a “no jab, no job” policy, while others stopped short of mandates but encouraged and incentivized vaccine uptake …

An Integrated Framework For Establishing Long-Term Transportation Management Strategies Promoting Sustainable Urban Growth, M Imtiaz Rahman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Urban land areas are experiencing a more rapid expansion compared to their population growth on a global scale. This phenomenon, known as urban sprawl, is characterized by low-density development in the outskirts of cities. This unplanned urban growth leads to changing urban transportation patterns, posing a threat to sustainable development. In response, government agencies implement growth management practices, with transportation management strategies playing a crucial role in achieving sustainable urban growth. However, developing effective growth management strategies is difficult because of several challenges, including limited understanding of the key influencing factors, the complex interdependencies among these factors, and the uncertainties …

Interactions Between Myeloid Cells And Neutrophil Extracellular Traps In Pancreatic Ductal Adenocarcinoma, Hillary Gabrielle Pratt

Graduate Theses, Dissertations, and Problem Reports (ETD)

The 5-year-survival rate for pancreatic ductal adenocarcinoma (PDAC) is only 12% due in part to a lack of therapeutic strategies that target the pathophysiology of the disease. The only known curative therapy is surgical resection of the PDAC tumor, but only 20% of patients are eligible at the time of presentation. To improve outcomes for patients, new therapeutic options are needed. The PDAC tumor microenvironment (TME) is uniquely fibrotic and hypoxic, which is in part driven by the immune cell composition in the TME. Myeloid cells are a prominent immune infiltrate within the PDAC TME, so these cells have been …

Engineering Applications Of Artificial Intelligence To Forecast Production Of Shale Wells, Yasir Jassim Alkalby

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examines the application of artificial intelligence (AI) and supervised machine learning techniques to forecast production from unconventional shale wells, utilizing actual field measurement data over a period of two years. Traditional methods, such as decline curve analysis, offer valuable insights but often fail to fully capture the complex nuances affecting productivity and tend to rely excessively on empirical equations.

In this research, the AI-based Shale Analytics approach, introduced by Mohaghegh in 2017, is employed. This method leverages Big Data Analytics to identify unique patterns from actual field observations, enhancing the evaluation and quantification of various productivity factors, facilitating …

Defining Success For An Introductory Mathematics Non-Stem Pathway Course, Clark D. Metz

Graduate Theses, Dissertations, and Problem Reports (ETD)

The enduring debate surrounding college algebra, traditionally a gateway for STEM pathways, underscores the necessity for curricular evolution in response to the rising popularity of non-STEM majors. This dissertation explores the success of an applied college algebra course designed for non-STEM students. The study aimed to determine whether this alternative course could meet diverse student needs while promoting academic achievement and fostering positive attitudes towards mathematics. Findings revealed through a novel approach of a difference-in-differences analysis that students enrolled in the applied college algebra course exhibited higher pass rates due to the introduction of the new course. The lower failure …

The Role Of Synaptic Zinc Signaling In Excitatory Circuits Of The Mouse Auditory Cortex, Philip T R Bender

Graduate Theses, Dissertations, and Problem Reports (ETD)

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical synaptic microcircuits and their functional specificity. The pool of chelatable synaptic zinc is controlled by the zinc transport protein ZnT3, a protein which functions by moving free zinc into glutamatergic presynaptic vesicles, from which it is co-released with glutamate during synaptic transmission. Once synaptic zinc is released within the synaptic cleft, it acts on glutamate receptors on the post-synaptic spine, including ionotropic NMDA and AMPA receptors. While the inhibitory function of zinc on NMDA receptors …

Life Cycle Impacts Of Hardwood Forest Resources For Sustainable Bioenergy And Bioproducts In The Eastern United States, Jinghan Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

A life-cycle impact assessment of hardwood resources across the eastern United States was conducted based on the life-cycle inventory data for hardwood forest resource management and was integrated with the Forest Vegetation Simulator (FVS). This integration allowed for the analysis of forest carbon dynamics in the four subregions: northeast (NE), mid-Atlantic (MA), southeast (SE), and northcentral (NC). The system boundary was selected to be consistent with the A1 module (extraction and upstream production) required by an Environmental Product Declaration (EPD) for wood products. The results indicated that uneven-aged management (UA) yielded higher carbon stocks than even-aged management (EA) across all …

The Impact Stress On The Fracture Conductivity And The Productivity Of The Marcellus Shale Horizontal Well, Simon Hanna Menhem

Graduate Theses, Dissertations, and Problem Reports (ETD)

The increase in effective stress during depletion adversely impacts the productivity of the multi-stage fractured Marcellus shale horizontal well. The geomechanical properties and proppant size influence the degree of shale compaction, the fracture conductivity, and the well productivity. This study seeks to assess the impact of net stress increase during depletion on the productivity of multi-stage fractured Marcellus shale horizontal wells. To investigate the impact of the net stress increase, a model for Bogges-5H well was developed based on the petrophysical and geomechanical properties of the shale obtained from the core plugs and well logs measurements from the pilot (Bogges …

Pepperoni Roll Studios: Prototype Design For Creating And Operating A Podcast And Audio Production Student Organization At West Virginia University, Nicholas Kirk Kratsas

Graduate Theses, Dissertations, and Problem Reports (ETD)

As technology and audience demand change the traditional media landscape, student organizations at the university level, such as West Virginia University’s Student Media, are looking for ways to expand experiential learning opportunities for their students. This professional project seeks to address this need at West Virginia University by proposing and developing a prototype for a stand-alone community of practice for podcasting and audio editing as a student organization under the management of an advisor and professional staff. This project will not only justify the importance and timeliness of an experiential learning environment centered on podcasting but also culminate in generating …

Immunomodulation In Osteosarcoma: From Therapy To Diagnostics, Ryan Austin Lacinski

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteosarcoma (OS) is a rare pediatric bone malignancy. Those who develop advanced disease, often in the form of metastasis to the lung, experience poor five-year survival rates near approximately 25%. Considering minimal-to-no therapeutic breakthroughs have occurred for treatment of this disease since the 1980s, efforts to develop new therapeutics are underway. The goal of this dissertation was to initiate the preclinical efforts necessary to reinvigorate the use of immunostimulatory cytokine therapy for the treatment of OS and other solid tumors. This effort would not only include the development of the immunotherapeutic known as IL12ns, but also the clinical diagnostic tools …

Understanding Learners' Perception Of Virtual Reality-Assisted Learning In Engineering Education, Mohammad Samin Mansur

Graduate Theses, Dissertations, and Problem Reports (ETD)

Virtual reality (VR)-assisted learning may facilitate an immersive and interactive learning environment and enable learners to explore and interact with learning content at their own pace and interest. However, it is still unknown how well VR is received in engineering learning while empowering autonomy and personalization. The objective of this study is to investigate learners' perceptions of VR-assisted learning in engineering education while allowing learners to learn at their own pace, driven by their personal preference. To this end, experiments were conducted, in which thirty engineering students were recruited and immersed in a VR setting designed to deliver an interactive …

Traumatic Brain Injury Induces Cerebrovascular Dysfunction: Consequences For Ischemia And Cerebral Hypoperfusion, Bailey J. Whitehead

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic brain injury (TBI) is a significant health concern across the United States as well as the broader globe, affecting millions of individuals on an annual basis. While most recover from their TBI and resume their lives normally, some subsets of TBI survivors continue to experience impairments and increased risk for future diseases like cardiovascular disease, stroke, and aging related disease like Alzheimer’s Disease or VCID.

TBI remains a fundamentally difficult neurological injury to pin down mechanistically, due to the variability in severity, timing, and age of patient, among other factors. One significant factor in the pathology has consistently been …

Evaluation Of 50’ Frp Truss Bridges With Timber Decks, Maxwell Browning Carey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fiber-reinforced polymer (FRP) composites have become mainstream structural materials and are being utilized in many different structural applications because of their outstanding thermos-mechanical properties and other characteristics. These characteristics include exceptional corrosion resistance, energy absorption, durability, high strength-to-weight, stiffness-to-weight ratios, and others. Also, FRP composites are cost effective especially when accounting for the service life of such a material.

In this study, testing and analysis were performed at both the component as well as a structural system levels. Herein, two FRP truss bridges of different widths with 50 ft. spans underwent extensive testing and analysis in accordance with AASHTO specifications. …

Impact Of Tiered Implementation Of Clinical Decision Support System For Acute Kidney Injury And Nephrotoxin Exposure In Cardiac Surgery Patients, Christopher M. Justice Ii

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Nephrotoxin exposure may worsen kidney injury and impair kidney recovery if continued in patients with acute kidney injury (AKI).

Objective: To determine if tiered implementation of a clinical decision support system (CDSS) would reduce nephrotoxin use in cardiac surgery patients with AKI.

Methods: We assessed patients admitted to the cardiac surgery intensive care unit at a tertiary care center from January 2020 to December 2021, and August 2022 to September 2023. A passive electronic AKI alert was activated in Jul 2020, followed by an electronic nephrotoxin alert in March 2023. In this alert, active nephrotoxic medication orders resulted in …

Enhancing Reservoir Modeling And Simulation Through Artificial Intelligence And Machine Learning: A Smart Proxy Modeling Approach, Andrew Timothy Jenkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

The application of numerical reservoir simulation (NRS) has been a common approach within the oil and gas industry for decades, providing a means to model and forecast dynamic subsurface interactions, as a basis for reservoir management and development decisions. These techniques have expanded to application within carbon capture utilization and storage (CCUS) projects as domestic and global policy shift towards reducing carbon emissions while maintaining the energy needs of our modern society. NRS techniques have become a core process for permitting approval in Class VI (large-scale geological sequestration) wells due to the fundamental similarity of these types of subsurface processes. …

Improving Patient Self-Advocacy And Communication With Providers Through Diabetes Self-Management Education: Analyses From A Randomized Controlled Trial, Brenna Owens Kirk

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: West Virginia (WV), a rural state in Appalachia, has the highest type 2 diabetes mellitus (T2DM) prevalence in the United States. Open communication in the patient-provider relationship is an integral part of comprehensive chronic disease management. This is especially true for patients living with T2DM, a disease that requires many complex, daily self-management activities and is associated with increased emotional distress. However, patients living with T2DM are often reluctant to openly share their concerns regarding self-care with their provider. This study aimed to test the effectiveness of the Diabetes and Hypertension Self-Management Program (DHSMP), a 12-week group lifestyle …

Becoming A Homemaker In Appalachia: Building Bridges In Women's Flat Track Roller Derby, Jessica Lynn Lough

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study sought to explore how six women in Central Appalachia negotiated embodied subjectivity and agency across discourses and gendered power relations. Women living in central Appalachia who play roller derby occupy a unique social position in which to position this study, as many are simultaneously challenging traditional gender norms and engaging in a highly physical and competitive sport that involves using their bodies relationally. Specifically, by conceiving women as vehicles of power and women’s flat track roller derby as a public pedagogy, I sought to trace what ‘doing’ a roller derby identity does to transform and advance their knowledge …

Developing And Adapting An Art Therapy Mask Creation (Atmc) Intervention For Individuals With Traumatic Brain Injury (Tbi) Across Select Clinical And Non-Clinical Settings, Stephen John Heck

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study aimed to explore the feasibility and adaptation of the Art Therapy Mask Creation (ATMC) technique in select clinical and non-clinical settings for individuals with traumatic brain injuries (TBIs). Utilizing the Consolidated Framework for Implementation Research (CFIR), qualitative interviews were conducted to assess barriers, facilitators, and feasibility of implementing the ATMC. Major findings included the ATMC’s adaptability across diverse settings, the flexibility and accessibility of art therapy as an intervention, and the significance of addressing emotional and psychological needs in individuals with TBIs. These insights contributed to understanding evolving healthcare practices, the role of technology, the importance of human …

Examining The Online Marketing Of Sport Psychology Services By Certified Mental Performance Consultants: A Rhetorical Analysis, Jaxson S. Judkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

In recent years, Certified Mental Performance Consultants (CMPCs) have increased their footprint in social media to connect with those that seek sport psychology services (Cotterill & Symes, 2014). The aim of this study was to identify what social media platforms are most used among CMPCs and what persuasive elements are used to draw in potential clients. All active CMPCs from 1992 to 2023 were examined to determine the most popular social media platforms used, followed by an analysis of 219 CMPCs based on their ownership of a LinkedIn account and professional website. Results indicated that LinkedIn and the consultants’ custom …

Cell-Type-Specific Effects Of Synaptic Zinc In Mouse Auditory Cortex, Mason Mccollum

Graduate Theses, Dissertations, and Problem Reports (ETD)

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical synaptic microcircuits and their auditory tuning properties. Stimulus-specific adaptation is a hallmark of sensory processing in which a repeated stimulus results in diminished successive neuronal responses, but a deviant stimulus will still elicit robust responses from the same neurons. Recent work has established that synaptically released zinc is an endogenous mechanism that shapes neuronal responses to sounds in the auditory cortex. Here, to understand the role of zinc signaling in the auditory cortex and the …

Planar Semiconductor-Superconductor Topological Quantum Devices: Realistic Modeling Tools, Purna Prasad Paudel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Planar semiconductor-superconductor (SM-SC) heterostructures hold significant promise for realizing topological superconductivity and hosting Majorana zero modes (MZMs) --- particle-hole symmetric quasiparticle excitations that emerge as localized zero-energy modes either at the edges of one-dimensional topological SCs or at the vortex cores of two-dimensional topological SCs. Due to their non-Abelian exchange statistics and topological protection, MZMs are prime candidates for constructing topological qubits and achieving fault-tolerant topological quantum computation. Despite notable progress, significant experimental and engineering challenges remain to realizing functional MZM-based qubits. One major challenge is the small topological gap achievable in these systems, rendering MZMs fragile against disorder. Additionally, …

Development Of Lab-On-A-Chip Platforms Incorporating A Novel Acoustic Atomization Induced Pump Based On A Vibrating Sharp Edge Capillary., Balapuwaduge Lihini Tharanga Catherine Mendis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Capillary Vibrating Sharp-edge Ionization device (cVSSI device) was developed by our laboratory with a low cost and an easy fabrication procedure. The generation of small liquid droplets by this technique has been used as an ionization source for mass spectrometry analysis platforms. On usual applications incorporating the cVSSI device a syringe pump was connected to the back end of the vibrating sharp tip capillary to ensure continuous loading of sample into the capillary to sustain the ionization process at the tip end of the vibrating sharp tip capillary. We were able to observe that upon the generation of droplets the …

Testing A Conceptual Model Of Age, Gender, Perceived Discrimination And Well-Being, Kelly Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Both age and gender are personal characteristics that are at least in part outwardly visible and act as a category for social judgments (Cuddy & Fiske, 2002). The current study examined associations among individuals’ views on their aging, their gender typicality, well-being, and perceived discrimination. Research Question 1 asked whether views on aging and gender typicality interact to influence perceptions of discrimination; Research Question 2 explored the same potential interactions’ influence on well-being. Research Question 3 explored whether any interaction between views on aging and gender typicality and well-being was mediated by perceptions of discrimination. Participants represented the adult life …

The Effects Of Diet-Induced Obesity On Cerebral Microvascular Bioenergetics, Alec Anthony Hanshew

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obesity is a worldwide epidemic but is especially a concern in the United States with over 40% of the population being obese. Obesity is known to cause increased metabolic demand, systemic inflammation, peripheral vascular dysfunction, and increased levels of oxidative stress and reactive oxygen species (ROS). However, the role of obesity on cerebrovascular bioenergetic function has not been fully elucidated. This study aimed to determine the impact of diet-induced obesity on cerebrovascular bioenergetics. 72, 6-month-old C57Bl/6 male and female mice were randomized into control and HFD groups. Control mice were subjected to the feeding of standard chow (18% fat, 24% …