Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Graduate Theses, Dissertations, and Problem Reports (ETD)

Discipline
Keyword
Publication Year
File Type

Articles 751 - 780 of 3022

Full-Text Articles in Entire DC Network

Examining The Intersection Of Gender And Age In Victim Blaming, Jerin Lee Jan 2019

Examining The Intersection Of Gender And Age In Victim Blaming, Jerin Lee

Graduate Theses, Dissertations, and Problem Reports (ETD)

Victim blaming refers to an attributional tendency in which some level of responsibility for a negative outcome is placed on victims (Maes, 1994). Many victims of crimes face stigmatization in the form of blame from friends, acquaintances, the criminal justice system, media, strangers, and even perpetrators of the crimes themselves (e.g., Cross, Parker, & Sansom, 2019; Gordon & Riger, 1991). Victim characteristics, type of crime, and observer characteristics all influence victim blaming tendencies. However, no studies to date have tested whether these factors in combination elicit differential reactions to victims of crimes. The present research tested how the intersection of …


Pain Relief Knowledge, History, And Expectations Among Emergency Dental Patients, Daniel C. Brawley Jan 2019

Pain Relief Knowledge, History, And Expectations Among Emergency Dental Patients, Daniel C. Brawley

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction

Dentists frequently treat and manage patients with acute dental pain. Patients often seek care to treat their pain. As a part of that treatment, it is common for providers to use both prescription and non-prescription medications in the management of the patient’s dental pain. This study focused on understanding the patient’s knowledge, history and expectations regarding prescription and non-prescription medication in the management of their dental pain.

Methods

A self-report survey was developed, using Likert-type scales, consisting of 32 items, including standardized, psychometrically-tested instruments. The survey was administered to 108 adult outpatients who reported to the West Virginia University …


Promoting Cognitive And Fine Motor Development In The Art Room For Young Students With Exposure To Trauma: An Exploratory Case Study., Tiffany Marie Minuci Jan 2019

Promoting Cognitive And Fine Motor Development In The Art Room For Young Students With Exposure To Trauma: An Exploratory Case Study., Tiffany Marie Minuci

Graduate Theses, Dissertations, and Problem Reports (ETD)

Despite the overwhelming research that suggests visual artmaking experiences can produce positive outcomes for individuals, many state art education policies fail to implement and integrate the arts into core academic curriculums. Specifically in the state of West Virginia, kindergarten through twelfth grade students often lack the access to a quality and consistent art education. With high teacher-pupil ratios and inclusive learning environments, educators face the difficult task of meeting all the individual needs of their students’ in the classroom. This not only affects whole student populations, but also poses risks for children who have been exposed to trauma. Traumatic experiences …


Performance Study Of An Unconventional Breathresponse Papr Against A N95 Ffr And Conventional Paprs, Huihui Yang Jan 2019

Performance Study Of An Unconventional Breathresponse Papr Against A N95 Ffr And Conventional Paprs, Huihui Yang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Healthcare workers (HCWs) are the first responders when infectious pathogens occur. Powered air-purifying respirators (PAPRs) are one of the most widely used personal protective equipment for healthcare workers. Currently, few studies have been performed with HCWs in the actual healthcare work environments to assess discomforts, acceptance and protective efficiency towards wearing and use of PAPRs. The main purpose of this dissertation was to introduce and assess a brand new unconventional PAPR (Koken breath-response PAPR). The protection performance and user preferance of this unconventional PAPR were studided and compared to that of a N95 FFR and traditional PAPRs.

Firstly, a laboratory …


Dispositional Empathy And Autonomic Reactivity During A Comfort Interaction, Alaina G. Tiani Jan 2019

Dispositional Empathy And Autonomic Reactivity During A Comfort Interaction, Alaina G. Tiani

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of the current study was to examine the association between dispositional (trait) empathy and autonomic reactivity during dyadic interactions among women enrolled in undergraduate psychology courses. The primary research question was: do individuals who are deemed higher in dispositional empathy according to self-report exhibit differential autonomic reactivity patterns during a task in which they are asked to comfort another student experiencing emotional distress than those who are deemed lower in dispositional empathy? The literature on this relation has been mixed and has utilized photos or videos to evoke emotion; thus this study sought to examine the relation between …


Mirror, Mirror In The Chamber: Effects Of Social Stimuli On Operant Behavior, Michael Steele Yencha Jan 2019

Mirror, Mirror In The Chamber: Effects Of Social Stimuli On Operant Behavior, Michael Steele Yencha

Graduate Theses, Dissertations, and Problem Reports (ETD)

The variables affecting social behavior are myriad, making the prediction and control of behavior occurring in social contexts relatively difficult. One can attempt to create a controlled social context in the laboratory by introducing a second organism into an operant chamber. To investigate effects of social stimuli on operant responding, key pecking responses of three pigeons were maintained on a variable-interval (VI) schedule of reinforcement in Experiment 1, and the key pecking responses of three additional pigeons were maintained on a three-component multiple schedule in Experiment 2. The components included a variable-ratio (VR) schedule, a fixed-interval (FI) schedule, and a …


Effects Of Teacher Training In Trial-Based Functional Analysis Via Video Modeling, Mary Haspel Jan 2019

Effects Of Teacher Training In Trial-Based Functional Analysis Via Video Modeling, Mary Haspel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Trial-based functional analysis (TBFA) is an efficient strategy for assessing challenging behavior in the classroom and a necessary step in developing effective functional assessment- based interventions (FABI). However, researchers have identified several barriers limiting the applicability of this practice in schools, including difficulty in (a) training teachers to mastery; (b) assessing whether teachers can implement this practice independently, with fidelity, in natural settings; and (c) determining whether teachers can use functional analysis (FA) to identify functions of problem behavior and develop effective interventions. This study will address these gaps in the literature by using a novel approach for training teachers …


Predictors And Health Outcomes Of Treatment-Resistant Depression Among Adults With Chronic Non-Cancer Pain Conditions And Major Depressive Disorder, Drishti Shah Jan 2019

Predictors And Health Outcomes Of Treatment-Resistant Depression Among Adults With Chronic Non-Cancer Pain Conditions And Major Depressive Disorder, Drishti Shah

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding major depressive disorder (MDD) as a comorbidity in patients with chronic non-cancer pain conditions (CNPC) is of importance because of the high prevalence and well documented bi-directional relationship between MDD and pain. Furthermore, presence of CNPC among adults with MDD often reduces benefits of antidepressant therapy, thereby increasing the possibility of treatment resistance. Treatment-resistant depression (TRD) commonly defined as insufficient response to multiple antidepressant trials, often worsens depression and pain symptoms and can amplify the clinical and economic burden among adults with CNPC and MDD. Additionally, long-term opioid therapy (LTOT) may be prescribed at a higher rate to adults …


Service Dogs For Veterans With Ptsd: Taxonomy, Work Stress Reduction, And Matching, Lindsay Parenti Jan 2019

Service Dogs For Veterans With Ptsd: Taxonomy, Work Stress Reduction, And Matching, Lindsay Parenti

Graduate Theses, Dissertations, and Problem Reports (ETD)

Research suggests that many veterans with post-traumatic stress disorder (PTSD) struggle with reintegration (Sayer et al., 2010), but are unlikely to seek help or complete treatment (Schottenbauer et al., 2008). To make matters worse, available treatment options are often time consuming, challenging, and/or associated with negative side effects (Carafano & Hutchinson, 2017). Using animals as a treatment modality for veterans with PTSD is an emerging topic of interest and has shown promise (Owen, et al., 2016; Richie et al., 2016). However, several factors have hindered the advancement of this field. Obstacles include a lack of standard terminology and classification system, …


The Working Public’S Perceptions Of Service Dogs: A Phenomenological Investigation Of Gatekeepers’ Experiences, Angela M. Dial Jan 2019

The Working Public’S Perceptions Of Service Dogs: A Phenomenological Investigation Of Gatekeepers’ Experiences, Angela M. Dial

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to capture the essence of the working public’s experiences with, and perceptions of service dogs. The population for the study was the working public of Kentucky, who through their employment, have experienced first-hand the phenomenon. A phenomenological framework informed the research design. In-depth, unstructured interviews were conducted to obtain data. Interview transcriptions were analyzed according to suggestions from Moustakas (1994) and Hycner (1985) regarding phenomenological research. The results of this research study naturally formed into five themes. Findings showed prevalent misunderstandings, confusion and lack of knowledge regarding service dogs, including how to identify a …


Los Ritmos Latinoamericanos Como Estrategia De Resistencia En La Ópera La Ruta De Su Evasión (2017) De Abya Yala Y Carlos Castro, Pamela Zamora Quesada Jan 2019

Los Ritmos Latinoamericanos Como Estrategia De Resistencia En La Ópera La Ruta De Su Evasión (2017) De Abya Yala Y Carlos Castro, Pamela Zamora Quesada

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this Master’s thesis I examine the most recent Costa Rican opera The Path of Avoidance (2017), produced by the Cultural Association for Performing Arts Abya Yala, directed by Roxana Ávila and composed by Carlos Castro, based on the homonymous novel of Yolanda Oreamuno (1948).Through a semiotic analysis, I will discuss how the innovative manner of incorporating Latin American rhythms such as salsa, bolero, vals criollo, bossa nova and tango is a musical strategy which promotes a problematization of the gender dominant discourse and patriarchal context. Simultaneously, these rhythms offer a way of resistance on the direct or psychological violence …


An Assessment Of The Methods Used To Teach Content Skill Sets Required For The Introduction To Agriculture, Food, And Natural Resource Course, Lee I. Wright Jan 2019

An Assessment Of The Methods Used To Teach Content Skill Sets Required For The Introduction To Agriculture, Food, And Natural Resource Course, Lee I. Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

Numerous studies have shown that students learn best when theory is applied to hands-on experiences. Traditionally, vocational agriculture, which evolved into agricultural education, has incorporated hands-on learning. For example, students typically raise livestock and crops as part of supervised agricultural experiences; learn to use chain saws, tractors, hay rakes, balers and other equipment found on farms; and basic metal working skills. They also sample soil and water to test for mineral levels and types of pollution that might affect agricultural practices. The purpose of this study, which incorporates a survey of agricultural education teachers in West Virginia, is to determine …


Comparing Measures Of Physical Activity Intensity, Duration, And Frequency Using Receiver Operator Characteristic Curve Analyses, Abigail M. Nehrkorn-Bailey Jan 2019

Comparing Measures Of Physical Activity Intensity, Duration, And Frequency Using Receiver Operator Characteristic Curve Analyses, Abigail M. Nehrkorn-Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

The United States Department of Health and Human Services (HHS) recommends adults to engage in weekly moderate- or vigorous-intensity physical activity based on its association with various physical and psychological health benefits (HHS, 2008; Schoenborn, Adams, & Peregoy, 2013). These physical activity recommendations contain important information for three physical activity components: intensity, frequency, and duration. The current physical activity literature contains gaps, with a lack of specificity for which components are being studied. Although some of the literature does describe the physical activity components, there are many discrepancies in the level of agreement across subjective and objective measures, along with …


Predictors Of Perceived Multicultural Competence Among Neuropsychological Trainees, Hannah K. Greenbaum Jan 2019

Predictors Of Perceived Multicultural Competence Among Neuropsychological Trainees, Hannah K. Greenbaum

Graduate Theses, Dissertations, and Problem Reports (ETD)

Multicultural competence is necessary to provide psychological services to an increasingly diverse population (Sue, 2001). It is established that multicultural competence is important for training in psychology (Bodin et al., 2014; Diaz-Santos & Hill, 2016). Despite increased interest in recent years, multicultural competence in neuropsychology has not progressed in parallel with the focus of multiculturalism in psychology broadly (Rivera Mindt, Byrd, Saez, & Manly, 2010). Little is known about multicultural assessment, and it is not yet known what factors in training contribute to perceived multicultural competence in neuropsychological trainees (Elbulok-Charape, Rabin, Spadaccini, & Barr, 2014). The primary purpose of this …


Political Trust In Kosovo: Exploring Cultural And Institutional Dynamics, Ermira Babamusta Jan 2019

Political Trust In Kosovo: Exploring Cultural And Institutional Dynamics, Ermira Babamusta

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this dissertation I examine political trust perceptions across different political-legal institutions and actors in Kosovo. I evaluate the levels of political trust using cultural and institutional performance explanations to investigate the key factors that have an impact on political trust. The study explores national political trust and international political trust, considering many domains of political trust: government, political leaders, political parties, Kosovo Courts, Kosovo Police, NATO, United Nations, European Union, and the Kosovo Specialist Court. There is growing concern about lower levels of political trust across Europe, especially in post-communist countries. In this study, I make the case that …


Automatic Kinship Verification In Unconstrained Faces Using Deep Learning, Naman Kohli Jan 2019

Automatic Kinship Verification In Unconstrained Faces Using Deep Learning, Naman Kohli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Kinship verification has a number of applications such as organizing large collections of images and recognizing resemblances among humans. Identifying kinship relations has also garnered interest due to several potential applications in security and surveillance and organizing and tagging the enormous number of videos being uploaded on the Internet. This dissertation has a five-fold contribution where first, a study is conducted to gain insight into the kinship verification process used by humans. Besides this, two separate deep learning based methods are proposed to solve kinship verification in images and videos. Other contributions of this research include interlinking face verification with …


Acute And Repeated Effects Of Synthetic Cannabinoid Agonism And Cannabinoid Receptor 1 Positive Allosteric Modulation, Kristen R. Trexler Jan 2019

Acute And Repeated Effects Of Synthetic Cannabinoid Agonism And Cannabinoid Receptor 1 Positive Allosteric Modulation, Kristen R. Trexler

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent years have seen a rise in the diversity and use of synthetic cannabinoids. Currently, there is little known about the effects of specific synthetic cannabinoid compounds. As such, little research has been done evaluating the acute and chronic effects of synthetic cannabinoid administration or the development of tolerance and withdrawal. The present study aimed, in part, to evaluate the acute and repeated effect of a third-generation synthetic cannabinoid, AB-FUBINACA. Mice were treated with AB-FUBINACA (0.1-3 mg/kg, i.p.) or vehicle and were tested repeatedly in the tetrad battery of assays, which included tests of catalepsy, antinociception, hypothermia, and locomotor activity. …


The Relationship Between Social Skills And Problem Behaviors In Adolescent Males With Autism Spectrum Disorders, Amanda Armstrong Randall Jan 2019

The Relationship Between Social Skills And Problem Behaviors In Adolescent Males With Autism Spectrum Disorders, Amanda Armstrong Randall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adolescent males with autism spectrum disorder commonly display an increased prevalence of problem behaviors and persistent deficits in social skills when compared to their typically developing peers. The present study deployed a single subject, multiple-baseline design to investigate the use of the social skills training program Super Skills: A Social Skills Group Program for Children with Asperger Syndrome, High-Functioning Autism and Related Challengesto promote enhanced social skills and minimize problem behaviors. Two groups of adolescent males with autism (N = 6) participated in weekly social skills training groups also containing typically developing peers (N = 3) once …


The Association Of Attitude, Perceived Behavioral Control, And Intention With Fruit And Vegetable Intake Among Rural West Virginian Residents With Pre-Diabetes In Mineral And Hampshire Counties, Diana Leigh Niland Jan 2019

The Association Of Attitude, Perceived Behavioral Control, And Intention With Fruit And Vegetable Intake Among Rural West Virginian Residents With Pre-Diabetes In Mineral And Hampshire Counties, Diana Leigh Niland

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Association of Attitude, Perceived Behavioral Control, and Intention with Fruit and Vegetable Intake among Rural West Virginian Residents in Mineral and Hampshire Counties with Pre-diabetes

Introduction: Pre-diabetes affects approximately 84.1 million adults in the United States. Pre-diabetes is one of the leading predictors of type 2 diabetes. West Virginia ranks number one in the prevalence of diabetes. Fruit and vegetable intake may assist in reducing risk for pre-diabetes. However, most adults do not consume the recommended daily amount. There are no studies investigating the fruit and vegetable intake (FVI) of rural West Virginian residents with pre-diabetes.

Method: After IRB …


Cognitive And Affective Influences On Decision-Making Strategies And Outcomes, Michaela S. Reardon Jan 2019

Cognitive And Affective Influences On Decision-Making Strategies And Outcomes, Michaela S. Reardon

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examines how factors such as emotion and planning abilities, determine decision-making strategies and outcomes. Consumer-based decision tasks are one way for researchers to measure the decision-making process and outcomes of individuals, while bringing an element of reality to the task through the utilization of decisions about everyday items that someone might purchase (e.g., a car, apartment, etc.). Using these types of tasks, researchers can measure the quality of a decision (e.g., did the participant come up with the best solution?), as well as the decision or search strategy. Previous research shows that cognitive factors are important when individuals …


Differences In Sexual Delay Discounting Among In-Treatment Adults With Opioid Use Disorder, Jonathan J.K. Stoltman Jan 2019

Differences In Sexual Delay Discounting Among In-Treatment Adults With Opioid Use Disorder, Jonathan J.K. Stoltman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Previous research has found impulsive decision-making to be a core component of addiction (Moody, Franck, Hatz, & Bickel, 2016). One way to measure impulsive choice is through the use of a delay discounting task. The delay discounting task provides a way to measure choice of immediate, smaller rewards compared to delayed, larger rewards (Odum, 2011b). An emerging area of research in addiction science is the intersection of addiction and sexual health. Previous sexual delay discounting research has focused on whether attractiveness or STD risk can shift the likelihood of waiting until a condom was available (Johnson & Bruner, 2012). This …


Leveraging Writing And Photography Styles For Drug Trafficker Identification In Darknet Markets, Wei Song Jan 2019

Leveraging Writing And Photography Styles For Drug Trafficker Identification In Darknet Markets, Wei Song

Graduate Theses, Dissertations, and Problem Reports (ETD)

Due to its anonymity, there has been a dramatic growth of underground drug markets hosted in the darknet (e.g., Dream Market and Valhalla). To combat drug trafficking (a.k.a. illicit drug trading) in the cyberspace, there is an urgent need for automatic analysis of participants in darknet markets. However, one of the key challenges is that drug traffickers (i.e., vendors) may maintain multiple accounts across different markets or within the same market.

To address this issue, in this thesis, we propose and develop an intelligent system named uStyle-uID leveraging both writing and photography styles for drug trafficker identification at the first …


Henosis Experience In Gaming: A Metric For Adjustments To Global Schema And Appraised Meaning, Evan Robert Watts Jan 2019

Henosis Experience In Gaming: A Metric For Adjustments To Global Schema And Appraised Meaning, Evan Robert Watts

Graduate Theses, Dissertations, and Problem Reports (ETD)

Meaningfulness is a media gratification distinct from enjoyment characterized by feelings of insight, contemplation, and poignancy. Video games, too, can elicit experiences of meaningfulness, but the mechanisms underlying meaningfulness are unclear and in need of further exploration. Adapting work from existential psychology, this research proposes the construct of henosis as one mechanism that might contribute to meaningful video game experiences. Henosis is a response to experiences in which a person’s fundamental schema about the world (global schema) is challenged by an event which contradicts this schema. Henosis describes the process by which this discrepancy is resolved via either reappraising the …


Efficacy Of Cognitive Training Intervention With A Coaching Component On Attention And Response Control In Emerging Adults, Thomas Craig Foster Jr Jan 2019

Efficacy Of Cognitive Training Intervention With A Coaching Component On Attention And Response Control In Emerging Adults, Thomas Craig Foster Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cognitive training, a nonpharmacological intervention for attention and learning-related difficulties, is a promising treatment option for emerging adults. The aim of this study was to explore the efficacy of a cognitive training program with a coaching component on measures of attention and response control in university students. Between 2014 and 2017, 39 students with reported attention concerns engaged in a cognitive training program over ten weeks (20 sessions) at a university counseling center. Differences in participants’ attention and response control as measured by the IVA-2 Continuous Performance Test (CPT) were evaluated before and after the intervention. Demographic data, including clinician …


Untangling The Reciprocal Relation Of The Behavioral And Physiological Immune Systems, Baris Sevi Jan 2019

Untangling The Reciprocal Relation Of The Behavioral And Physiological Immune Systems, Baris Sevi

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past decade, there has been an exponential increase in the study of the Behavioral Immune System (BIS), a suite of psychological processes that serves an infectious disease avoidance function. The BIS is proposed to be inherently intertwined with the physiological immune system. However, very few studies have actually demonstrated this fundamental, theoretical assumption. The purpose of this thesis was to test the possible relation between the physiological and behavioral immune systems in two studies. In Study 1 (N = 388), the relation between implied activation of the physiological immune system and BIS sensitivity was examined. Participants who reported …


Resurgence Of Academic Responses, Catherine Louise Stephens Jan 2019

Resurgence Of Academic Responses, Catherine Louise Stephens

Graduate Theses, Dissertations, and Problem Reports (ETD)

Resurgence is the recurrence of a previously reinforced response after a more recently reinforced response is placed on extinction. Resurgence may explain the recurrence of socially appropriate behavior, including academic responding, but this had not yet been empirically demonstrated. The aim of this study was to determine if resurgence would occur when a participant solved quadratic equations using multiple methods. Each participant was taught two methods of solving quadratic equations across experimental phases, followed by a phase in which neither method resulted in the correct solution. In the first phase, only simple factoring was reinforced. In the second phase, only …


The Dirt Of Development: Nature's Role In Social-Emotional Development And Parent-Child Connectedness, Hayley Johanna Lindsey Jan 2019

The Dirt Of Development: Nature's Role In Social-Emotional Development And Parent-Child Connectedness, Hayley Johanna Lindsey

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to examine associations between nature connectedness, parent-child connectedness, and the development of prosocial behavior. Nature connectedness pertains to the strong emotional affinity towards the natural environment and is linked with happiness, stress reduction, and good health. Prosocial behavior refers to actions or behaviors done with the intent to help others. This study consisted of 467 parent-informants that gathered information on the parent’s nature connectedness, the child’s nature connectedness, the parent-child connectedness, and the child prosocial behavior. Gaps in the literature were addressed by analyzing the role that parent nature connectedness has in predicting child …


Shame And Guilt: The Good, The Bad, And The Ugly, Raika Sadeghein Jan 2019

Shame And Guilt: The Good, The Bad, And The Ugly, Raika Sadeghein

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past few decades, we have witnessed a growing body of literature on emotions in the consumer behavior domain. Emotions are defined as “mental states of readiness that arise from appraisals of events or one’s own thoughts” (Bagozzi, Gopinath, & Nyer, 1999, p. 184). Marketers have examined the role of emotions as stimuli, mediators, moderators, and responses to the environment. The broad topic of emotions includes subtopics such as impact of emotions on consumption, attitudes, and behavioral intentions, emotional responses to market stimuli, and the impact of emotions on cognition. However, although the study of emotions is pivotal to …


The Impact Of Student Facilitation On Student Engagement In Asynchronous Online Discussion, Robin Bowen Jan 2019

The Impact Of Student Facilitation On Student Engagement In Asynchronous Online Discussion, Robin Bowen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lack of engagement in asynchronous online discussion is a common issue due to insufficient participation, disinterest in discussion, superficial discussion, and the influence of peer behaviors. The purpose of this study was to enhance student engagement in asynchronous online discussion by using student-led discussion and peer assessment. A mixed methods design was utilized in this study to offset quantitative and qualitative research weaknesses and to draw on the strengths of both (Plano Clark & Creswell, 2008). The control group participated in the discussion managed by the instructor, who posted weekly discussion questions to a class discussion board and facilitated the …


Elucidating A Common Mechanism Of Proteasome Impairment In Neurodegenerative Disease And Its Pharmacological Intervention, Tiffany Ann Thibaudeau Jan 2019

Elucidating A Common Mechanism Of Proteasome Impairment In Neurodegenerative Disease And Its Pharmacological Intervention, Tiffany Ann Thibaudeau

Graduate Theses, Dissertations, and Problem Reports (ETD)

Proteostasis is maintained by several systems in the cell including the ubiquitin-proteasome system (UPS), chaperones, chaperone-mediated autophagy, and macroautophagy. The UPS is the principle route for the degradation of intracellular misfolded, damaged, or unneeded cellular proteins and has a critical role essential every cell process, including: cell cycle progression, transcriptional regulation, genome integrity, apoptosis, immune responses, and neuronal plasticity. When the efficiency of protein degradation is perturbed, misfolded and damaged protein aggregates can accumulate to toxic levels and cause neuronal dysfunction, which may underlie many neurodegenerative diseases. It is widely appreciated that soluble oligomers of misfolded proteins (e.g. Aβ, Alzheimer’s; …