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Amelioration Of Mitochondrial Bioenergetic Dysfunction In Diabetes Mellitus: Delving Into Specialized And Non-Specific Therapeutics For The Ailing Heart, Andrya Jean Durr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Morbidity and mortality of the diabetic population is influenced by many confounding factors, but cardiovascular disease (CVD), remains the leading cause of death. Mitochondrial dysfunction is central in the development of cardiac contractile dysfunction, with decreased mitochondrial bioenergetic function, increased dependence on free fatty acid utilization, and a decrease in glucose utilization having been shown to contribute to contractile dysfunction. Strategies targeting the amelioration of mitochondrial bioenergetic function are attractive for limiting diabetes-induced heart failure, and preserving health-span. The goals of this dissertation were to assess two mitochondrial-centric approaches for the amelioration of mitochondrial and cardiac contractile dysfunction in diabetes …

Zonulin As A Mediator Of Psychological Stress And Periodontal Disease, Casey D. Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

The prevalence of chronic inflammatory diseases is on the rise. Some have posited the permeability of tight junctions in gastrointestinal epithelium tissues as a potential mechanism for precipitating inflammatory processes throughout the body. Zonulin is the only known modulator of tight junction permeability and has been implicated in numerous chronic inflammatory processes (e.g., proinflammatory cytokine production) and diseases, more generally. The role of zonulin in oral inflammation, however, has yet to be explored. Periodontal disease is the most common oral inflammatory condition and primary perpetrator of tooth loss. Periodontal disease also is associated with a number of other health problems …

Electronic Cigarette Dependence: User And Device Characteristic Predictors, Ashley E. Douglas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding the dependence potential of electronic cigarettes (ECIGs) is critical to informing prevention and regulatory efforts. Extant work on ECIG dependence is limited, in part due to the vast number of products that differ on their ability to deliver nicotine. Further, existing research is based largely on former/current cigarette smokers, and thus confounds dependence on nicotine via ECIGs versus cigarettes. This study evaluated ECIG device/liquid characteristics and use behaviors as predictors of ECIG dependence in a sample of experienced ECIG users who never smoked cigarettes. Participants completed an online survey that assessed ECIG device/liquid features, use behavior, and ECIG dependence. …

Analysis Of Emissions Profiles Of Hydraulic Fracturing Engine Technologies, Nicholas Joseph Wells

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past twenty years natural gas production in the United States has significantly increased. This is largely due to technological advancements in unconventional methods of horizontal drilling and hydraulic fracturing. With these new and improved technologies, the United States has been able to increase its natural gas dry production per year by 14.5 trillion cubic feet per year from 2001-2021, a 74.1% increase. Horizontal drilling allows the wellbore to have more contact with the source rock, thus allowing more hydrocarbons to be extracted. Hydraulic fracturing allows oil and gas companies to have access to low permeable source rock, previously …

Three Essays In Healthcare Economics And Policy Analysis, Tuyen Pham

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation research consists of three essays on healthcare economics and policy analysis. Chapter 1 investigates and explains the failure of a proposition on limiting dialysis clinic profits in California in 2018. The proposition would have required dialysis clinics to issue refunds to patients or their payers for revenue that exceeds 115% of the direct cost of treatment. In this chapter, a conceptual framework of how voters weigh costs and benefits is developed and two different empirical approaches, simple OLS and Double Post LASSO, are employed to identify key determinants of the voting outcome. The empirical results suggest that counties …

Uav Path Planning And Multi-Modal Localization For Mapping In A Subterranean Environment, Kieren Yoshiki Samarakoon

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of Unmanned Aerial Vehicles (UAVs), especially quadcopters, have become popular in academia and industry due to their small size and maneuverability. These UAVs can be programmed to autonomously execute missions that are usually difficult and risky for humans, such as subterranean exploration, infrastructure surveying, and even disaster response. However, inaccessible and remote environments pose a challenge in terms of navigation as they often lack access to Global Navigation Satellite System (GNSS) connections and lack features. To address these challenges, UAVs are equipped with multiple sensors to acquire different types of data. These include range, acceleration, and even images, …

Incidence Of Cancer, Depression, And Economic Burden Of Prescription Nsaids Among Older Adults With Osteoarthritis: Statistical And Machine Learning Approaches, Nazneen Fatima Mohammed Umer Shaikh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding the role of chronic inflammation among older adults is critical because of its implications on chronic inflammatory conditions as well as its interaction with anti-inflammatory medications. Osteoarthritis (OA) is a heterogeneous multi-faceted joint disease with multi-tissue involvement of varying severity, and increasing evidence demonstrates a key role of chronic inflammation in its pathogenesis. Approximately 30 million adults in the United States have OA, and it is reported that a large proportion (43%) of them are older than 65 years. OA is typically treated using non-steroidal anti-inflammatory drugs (NSAIDs) for minimizing pain and reducing inflammation. NSAIDs have consistently shown clinically …

Development Of An Entry-Scale Modeling Methodology To Provide Ground Reaction Curves For Longwall Gateroad Support Evaluation, Haochen Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

Longwall gateroad entries are generally subjected to severe mining-induced stress changes and deformations; they are prone to large roof falls, floor heaves, and rib sloughing. The standing support system in underground mines needs to be carefully designed to compensate for the mining-induced deformation of the surrounding rock mass and consecutively protect the integrity of gateroad entries. Local geology, together with mining-induced stress redistribution, influences the ground response and plays a major role in the performance of a standing support design. In the US, Support Technology Optimization Program (STOP) and its Ground Reaction Curve (GRC) design criteria have been applied to …

Development And Verification Of Flight Data Informed Performance Estimation And Prediction Simulation Tool For Small Electrical Multi-Rotor Uav, Nicholas Scott Borelle

Graduate Theses, Dissertations, and Problem Reports (ETD)

While small scale multi-rotor aircraft are becoming an increasingly large market with applications emerging every day, their ability to have both a high endurance/long range and a high speed/performance flight is severely limited. This leads to uncertainty in mission planning and aircraft design, specifically when deciding mission length and available on-board energy. Uncertainty like this leads to an increased chance of failure to complete the mission, and a failure to recover the aircraft. Considering that these aircraft are used by everyone from hobbyists to commercial companies to military personnel, the applications and missions being flown carry importance and a serious …

Utilizing The K18-Hace2 Mouse Model To Develop Protective Covid-19 Vaccines, Ting Y. Wong

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused by the respiratory virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Similar to other respiratory viruses, SARS-CoV-2 is transmitted through inhalation of respiratory droplets and aerosols from infected individuals. Once inhaled, SARS-CoV-2 utilizes the receptor binding domain (RBD) on the spike protein to bind to human Angiotensin Converting Enzyme 2 (hACE2) receptor to gain entrance into host cells to begin viral replication. SARS-CoV-2 infection can result in mild to severe cases of COVID-19 ranging from asymptomatic infections, cold or flu like symptoms to respiratory failure. The onset of the pandemic in …

The Effect Of A Standardized Handoff Tool On Communication, Interunit Transitions, And Wait Time: A Quality Improvement Project, Silvia N. Myndresku

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project sought not only to improve the communication and interunit transitions of care between emergency department providers (EDPs) and inpatient providers (IPs) using a standardized handoff tool, but also to reduce the Emergency Room (ED) wait time for patients admitted to the community hospital. The project employed a quantitative quasi-experimental pre-test/post-test design to explore provider satisfaction with an evidence-based standardized handoff tools and wait time. Forty-eight providers completed the survey before the I-PASS implementation, and 43 providers completed the survey post I-PASS implementation. Though not statistically significant, data indicates that wait time increased for the post-implementation months of December, …

Associations Between Self-Reported Awe And Heart Rate, Laura E. Bernstein

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fredrickson’s (1998, 2013) broaden and build theory states that positive emotions can expand our social and cognitive awareness and provide health benefits. Some positive emotions, such as awe, may operate differently. We sought to understand how subjective reports of awe, induced through videos, correlate with HR. We know that HR tends to decrease with age (Umetani et al., 1998), individuals have less physiological reactivity as they age (Blanchard-Fields, 2007), and older adults report more positive emotions than negative emotions (Mroczek & Kolarz, 1998). Given these findings, we were interested in understanding whether there were age differences in self-reported awe and …

Investigation Of Geomechanical Behavior Of Laminated Rock Mass Through Experimental And Numerical Approach, Qingwen Shi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Roof failure in the Appalachian underground coal fields occurs often in laminated shale. Laminated shale roof in coal mines fails in unique ways, such as cutter failure or delamination failure. Extensive studies have investigated the influential factors that cause laminated roof failure, which include in-situ stress, entry layout, roof span, and roof support. However, cutter failure continues to occur frequently and erratically. This is due to the lack of in-depth understanding of the inherent properties of the laminations, such as bedding plane strength, matrix strength, and bedding plane spacing, which in turn influence the geomechanical behavior of the laminated rock. …

Development Of A Transition Program For Young Adults With Type 1 Diabetes Progressing From Pediatric To Adult Care – A Feasibility Study, Elizabeth Ann Minchau

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Development of a Transition Program for Young Adults with Type 1 Diabetes Progressing from Pediatric to Adult Care – A Feasibility Study

Elizabeth A. Minchau

Background: Emerging adulthood requires a delicate balance of the competing social, educational, occupational, and financial demands typical of this developmental stage. This time period presents special challenges for adolescents with type 1 diabetes (T1D), who must also prioritize consistent medical follow-up and ongoing intensive self-care. Emerging adults with T1D struggle with glycemic control that is further exacerbated by an often-times disorganized transfer of care between pediatric and adult endocrinology practices. Substantial gaps in care …

Repercussions: The Pressure To Be Thin, Shuhan Liu

Graduate Theses, Dissertations, and Problem Reports (ETD)

My MFA thesis and supporting exhibition will highlight ceramics work I have created with the intention of dissecting the relationship between a soul and reality to convey the story of tension and anxiety and show it in a way that would let viewers identify with my discomfort and anxiety. The inspiration for my work came from the severe body anxiety that I faced that broke out during the three years of psychological stress caused by the pandemic. Using personal narratives as a starting point, I created object-based artwork that addresses the external pressures I feel to be skinny. As an …

Mountain Biking Mountaineers: Insights Into The West Virginia Mountain Biking Community, Connor Mullin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mountain biking is one of the most popular recreational activities in the United States. Beyond the increasing popularity of the sport, the technology is also changing, especially in terms of electric mountain biking. This new type of bike blends traditional mountain bikes with electric bikes, creating a potential new group of recreationists. The research on mountain biking, and more specifically electric mountain biking, is limited. The purpose of this study is to examine West Virginian mountain bikers by studying behaviors and motivations. There are no published studies focused on mountain biking in West Virginia, and therefore a need to fill …

Direct Ink Writing Printability – Ashby-Like Plots For Guided Design, Domenic Cipollone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Direct Ink Writing (DIW), an extrusion-based 3D printing technique, offers a broad application space. As such, the technique continues to find use in biomedical, flexible electronic, ceramic, and energy device applications, among others. With this broad application space comes an expanding material library of inks with diverse rheological and microstructural properties. This begs the question: what constitutes a printable ink? How does one define printability? And how does one design for printability?

Researchers currently have a broad understanding of what constitutes a printable ink. However, time and time again, inks with unique rheological properties and formulations are printed. Currently, ink …

Developing Artificial Intelligence Tools To Investigate The Phenotypes And Correlates Of Chronic Kidney Disease Patients In West Virginia, Marzieh Amiri Shahbazi

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Developing Artificial Intelligence tools to investigate the phenotypes and correlates of Chronic Kidney Disease patients in West Virginia

Marzieh Amiri Shahbazi

Chronic kidney disease (CKD) is responsible for disrupting the lives of 37 million people just in the USA, which is about 1 in 7 adults. CKD results in a gradual loss of kidney function over time. Sometimes CKD doesn’t produce any significant symptoms until it reaches an advanced stage. On the other hand, acute kidney injury (AKI) accounts for a sudden decline in the kidney’s function. As a result, the kidneys fail to filter waste materials from the …

Machine Learning Approaches To Improve Prediction In Health Care, Sadaf Kabir

Graduate Theses, Dissertations, and Problem Reports (ETD)

The availability of data and advanced data analysis tools in the health care domain provide great opportunities for the discovery of unknown or hidden patterns in clinical data. However, medical data is often incomplete and has poor quality, e.g., it contains missing values or too many unnecessary features. Majority of these issues are induced by uncertainty in clinical trials and examinations, such as human error, patients’ withdrawal during studies, malfunctioning of data collection equipment, and are generally inevitable. Properly addressing these issues can lead to the development of precise predictive models and consequently more reliable clinical decision making. Accurate predictive …

Bitter Sweet, Hanna M. Kesty

Graduate Theses, Dissertations, and Problem Reports (ETD)

This written document is the accompanying thesis for my Master of Fine Arts Exhibition, Bitter Sweet. The exhibition featured traditional framed prints with sculptural accents that reveal brutally honest negative personal experiences, interactions, and emotions, paired with delicately cute aesthetics. My work embodies the necessity of personal artistic expression to process years of emotional repression. The prints and sculptures in the exhibition focus around a collection of insults and harsh comments coupled with feelings of loneliness and isolation. I allow personal vulnerability to show, to reinforce that these moments have molded and shaped who I am and will continue to …

Detecting Adverse Drug Events Using A Deep Neural Network Model, Saminur Islam

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adverse drug events represent a key challenge in public health, especially with respect to drug safety profiling and drug surveillance. Drug-drug interactions represent one of the most popular types of adverse drug events. Most computational approaches to this problem have used different types of drug-related information utilizing different types of machine learning algorithms to predict potential interactions between drugs. In this work, our focus is on the use of genetic information about the drugs, in particular, the protein sequence and protein structure of drug protein targets to predict potential interactions between drugs. We collected information on drug-drug interactions (DDIs) from …

Identifying Factors That Increase Sustainability Of Swpbis In Us Middle Schools, Heather L. Hoffert

Graduate Theses, Dissertations, and Problem Reports (ETD)

School-wide positive behavior interventions and supports (SWPBIS) is a multi-tiered framework with decades of documented success in reducing problem behavior, increasing academic achievement, and promoting positive school climates. Approximately 20% of schools nationwide (n=26,000) implement SWPBIS (Kittleman et al., 2020). However, many schools that adopt SWPBIS abandon the program after only a few years of implementation. Therefore, it is necessary to investigate factors that promote sustainability of SWPBIS. By identifying factors that increase schools’ likelihood to sustain practices, we can target our implementation efforts both effectively and efficiently thereby improving student outcomes. The Benchmarks of Quality (BoQ) is used annually …

Passive Self-Ligating Brackets Vs. Conventional Brackets: Is There A Difference In The Transverse Dimension? A Systematic Review And Meta-Analysis, Justin Scott Tenbrook

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background and Objectives:

Self-ligating brackets have risen in popularity in clinical orthodontics, but many claims made by their manufacturers have been made without substantial evidence. Any differences among the bracket types are very small when consulting new peer reviewed literature testing their differences. Nevertheless, self-ligating brackets are still purported to be able to increase the dental transverse dimension more effectively than conventional brackets. In 2018, Yang et al. performed a systematic review on the transversal changes, space closure, and efficiency of conventional and self-ligating appliances. Since then, there were several clinical trials published in the literature comparing the mandibular arch …

The Effects Of Script Therapy In A Patient With Old Chronic Aphasia, Busra Ensar

Graduate Theses, Dissertations, and Problem Reports (ETD)

There are some gaps in the literature regarding the efficacy of script therapy in patients with chronic aphasia, particularly chronic aphasia that lasts for several years post-onset, in terms of treatments to improve functional communication during daily activities. This study investigates the relationship between script therapy and communication effectiveness and communicative efficiency. In this context, communication effectiveness was measured by the percent script correct, and communicative efficiency was measured by the total duration to produce the script and the mean duration of pauses at the beginning of sentences.

The efficacy of intensive script training on discourse effectiveness and efficiency was …

Eco-Material Rifts In South Asian Anglophone Fiction, Muhammad Manzur Alam

Graduate Theses, Dissertations, and Problem Reports (ETD)

I examine how South Asian Anglophone fiction represents the evolution and derangement of postcolonial ecologies, especially how unrelenting colonial and capitalist interventions affect the symbiotic relationship between subaltern people and nonhuman entities. The conceptual methodology develops from Karl Marx’s theory of “metabolic rift,” which illustrates how capitalist exportation of crops causes loss of important soil nutrients because the nutrients are consumed in distant locations and not returned to the original soil. My concept of “eco-material rifts” extends Marx’s idea to contend that the “rifts” have grown into more complicated and difficult to remediate modes of material rifts today. I scrutinize …

Screen Media Use Among Children And Adolescents – Applications Of Supervised And Unsupervised Machine Learning And Sentiment Analysis, Yifan Zhang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Screen media has become increasingly pervasive in our everyday lives and has profoundly changed the way people communicate and interact with each other. However, we are still unclear about the long-term influence of screen media use on our physical health, mental health, and social wellbeing. Children and adolescents are in an important stage of brain development and are susceptible to the environmental influence that screen media possess. This dissertation pursued three aims to address research gaps related to screen media use among children and adolescents: 1) identify topics and knowledge gaps in screen media use research among children and adolescents …

Quantifying Water Security In West Virginia And The Potomac River Basin, Eric Carl Edvard Sinius Sjostedt

Graduate Theses, Dissertations, and Problem Reports (ETD)

All healthy ecosystems, communities, and economies are founded on access to clean, adequate water sources to support ecosystem services, provide clean drinking water, and allow the production of water-intensive goods and services. The state of available water resources must be analyzed through the lens of water security, defined as the capability to safeguard sustainable access to adequate quantities of acceptable quality water for people, the economy, and ecosystems. Mountain regions are sources of freshwater resources for downstream regions, which produce disproportionately higher runoff than downstream regions. As a result, mountain regions are often referred to as natural water towers …

The Web And The Blockbuster Poster: An Examination Of The Impact Of Streaming Services On Movie Advertising, Holden Edward Strausser

Graduate Theses, Dissertations, and Problem Reports (ETD)

The year 2020 brought a widespread closure of movie theaters, exacerbating a trend wherein streaming services gained an increasing importance in movie distribution. This study examines how the changing nature of the motion picture distribution market after the advent of the streaming service is reflected in movie advertising, specifically the movie poster. The research uses a content analysis methodology to compare film posters across time, from before the beginning of streaming services to the arrival of the 2020 COVID-19 pandemic in the United States. Analysis is derived from Uses and Gratifications theory and scholarship on star power. The research shows …

Autonomous And Non-Autonomous Requirements For The C-Jun N-Terminal Kinase Signaling Pathway In Early Forebrain Development, Jessica G. Cunningham

Graduate Theses, Dissertations, and Problem Reports (ETD)

The cerebral cortex is responsible for a wide variety of high-level functions including cognition, sensory perception, fine motor control, and the orchestration of body movements. The cortex is comprised of cortical excitatory neurons and inhibitory interneurons, which are arranged in a highly organized fashion into different layers and regions. These two types of cells operate in a delicate balance between excitation and inhibition, which is critical for proper cortical circuitry. In order for the cortex to execute its numerous functions, it must both send and receive input to other brain regions through axonal connections. The organization within the cortex and …

Monitoring The Systemic Immune System To Understand And Improve The Efficacy Of Immunotherapy For Metastatic Osteosarcoma, Justin Edward Markel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteosarcoma (OS) is a complex tumor with no effective targeted therapies due to its genomic heterogeneity and pleomorphism. The immune response it creates, particularly against metastatic lesions, is considerable; however, various suppressive mechanisms induced by the tumor prohibit its effectiveness. The presence of infiltrating lymphocytes suggests that therapeutic disinhibition through checkpoint blockade could increase antitumor immunity, though none have been successful in clinical trials. The complexities of the immune response to OS tumors have yet to be unraveled; however, there is evidence to suggest that cell-mediated immunity (CMI, specifically T cells, Natural Killer [NK] cells, and myeloid-lineage cells [MLCs]) plays …