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Essays In The Consequences Of Occupational Regulation, Noah J. Trudeau

Graduate Theses, Dissertations, and Problem Reports (ETD)

Occupational regulation affects many people across many aspects of life. This dissertation research investigates the consequences of occupational regulation across three different areas of study: economic history, urban and regional economics, and health policy.

The first chapter investigates the historic licensing of emigrant agents. In the period following the US Civil War, firms wished to capitalize on the availability of African American labor. To do so they hired emigrant agents, also known as labor agents, to hire and help with the migration of individuals from the South. Faced with out-migration at the hands of the labor force, some southern states …

Comparison Of Antimicrobials And Delivery Methods On The Inactivation Of Listeria Monocytogenes On Apples, Rebecca B. Stearns

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Due to multi-state outbreaks of listeriosis on apples in 2015, 2017, and 2019, Listeria Monocytogenes (L. monocytogenes) has been deemed an emerging, under researched pathogen by the USDA-NIFA. Therefore, this study evaluated the efficacy of SaniDate 5.0®’s (SD) ability to inactivate L. Monocytogenes on apples when delivered through electrostatic sprayer (ES), garden sprayer (GS), and dip methods.

Methods: Organic apples were dip-inoculated with L. monocytogenes for 5 min and then dried for 10 min. Once dried, the inoculated apples were untreated (control), sprayed with water only, or treated with SD, 0.0064, 0.1, 0.25 and 0.50% for 20 …

Assessment Of Quechers Extraction Protocol For The Lc-Ms/Ms Detection Of Emerging Fentanyl Analogs In Biological Specimens For Clinical And Forensic Purposes, Kylea M. Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drug abuse within the United States is a dynamic and pervasive issue that affects the quality and life expectancy of our society. One of the major drug classes that are constantly utilized is opioids. Opioids are prescribed for pain management in patients suffering from cancer and other medical illnesses. Long-term use of opioids could lead to tolerance in humans, which poses a risk of reaching fatal overdose levels. Unfortunately, opioids are abused recreationally, and in some instances, individuals are unaware of the presence of dangerous synthetic drugs like fentanyl, hidden in materials such as heroin, cocaine, oxycodone, and methamphetamine. Recent …

Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.

Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.

Methods. A sequential explanatory mixed-methods design was used for aims 1 …

Gan-Based Super-Resolution And Segmentation Of Retinal Layers In Optical Coherence Tomography Scans, Paria Jeihouni

Graduate Theses, Dissertations, and Problem Reports (ETD)

Optical Coherence Tomography (OCT) has been identified as a noninvasive and cost-effective imaging modality for identifying potential biomarkers for Alzheimer's diagnosis and progress detection. Current hypotheses indicate that retinal layer thickness, which can be assessed via OCT scans, is an efficient biomarker for identifying Alzheimer's disease. Due to factors such as speckle noise, a small target region, and unfavorable imaging conditions manual segmentation of retina layers is a challenging task. Therefore, as a reasonable first step, this study focuses on automatically segmenting retinal layers to separate them for subsequent investigations. Another important challenge commonly faced is the lack of clarity …

Integrated Large Discontinuity Factor, Lamodel And Stability Mapping Approach For Stone Mine Pillar Stability, Mustafa Baris Ates

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this research is to develop a software tool that integrates the large discontinuity factor (LDF) and the Boundary Element Method software (BEM), LaModel, to allow stone mine operators to assess the impact of the large discontinuities on local pillar stability. National Institute for Occupational Safety and Health (NIOSH) published design guidelines for underground stone mines to guide the industry in designing pillar and roof support. These guidelines emphasize the impact of large, angular discontinuities on pillar strength. Esterhuizen et al. (2011) derived the large discontinuity factor (LDF) to account for the impact of discontinuities on pillar stability …

Calcite Depression In Bastnaesite-Calcite Flotation System Using Organic Acids, Emmy Muhoza

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bastnaesite is the primary source of light REEs, namely cerium (Ce), lanthanum (La), praseodymium (Pr), neodymium (Nd), to name a few. Bastnaesite is typically concentrated using the froth flotation beneficiation method. Flotation of bastnaesite suffers from high reagent consumption due to the similar surface characteristics of bastnaesite and associated gangue minerals, including calcite. Additionally, complex stages of high-temperature conditioning are often required to suppress the detrimental impact of dissolved calcium ions on the flotation of bastnaesite. This research seeks to investigate the capabilities of organic acids in the bastnaesite-calcite flotation systems to selectively depress calcite minerals and effectively chelate calcium …

Cross-Kingdom Interactions Shape Soil Biogeochemistry In Natural And Agricultural Ecosystems, Jennifer Lynne Kane

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microorganisms influence life on earth in innumerable ways, including in medical, industrial, environmental, and agricultural contexts. Given the increasingly apparent consequences of climate warming, interest in how to better predict and manage Earth’s carbon sinks has never been greater. Soil, the largest terrestrial carbon sink, harbors an incredibly taxonomically and functionally diverse microbial community. These soil-dwelling microbes govern the fate of soil carbon and nutrients by cycling organic matter as they live, grow, and die. It has only been relatively recently that technological advancement has allowed for in-depth surveys of the vast diversity of soil microbes. High throughput analytical capabilities …

Validity Evidence For The Male Depression Risk Scale-22 (Mdrs-22) In Younger And Older Adult Males, Montgomery T. Owsiany

Graduate Theses, Dissertations, and Problem Reports (ETD)

Men are two times less likely to be diagnosed with major depressive disorder than women. However, suicide rates are nearly four times higher in men than women, increasing to six times when comparing older men to older women. Given that affective disorders are present in most individuals who die by suicide, investigators have begun researching the possibility that depression presents differently in individuals who adhere to traditional masculine norms, leading to the conceptualization of masculine depression. Presently, one assessment for masculine depression shows strong reliability and validity evidence: the Male Depression Risk Scale-22 (MDRS-22). Despite burgeoning validity evidence for the …

Implementation Of A Training Program To Improve The Crna Precepting Experience At An Academic Medical Center, Megan Jean Gillespie

Graduate Theses, Dissertations, and Problem Reports (ETD)

Formal preceptorship training has been shown to improve the comfort and confidence with precepting across many disciplines. Currently, there is no training program in place for the Certified Registered Nurse Anesthetist (CRNA) preceptors at a large academic medical center in West Virginia. The overarching goal of this quality improvement (QI) project was to implement a formal preceptorship training for the CRNAs at the facility of interest. The training, or intervention, was the Preceptor Essentials Parts I and II on NetLearning. This project followed the pre-intervention-post-survey design. The participants were self-selected CRNAs. The survey results were analyzed using the Mann-Whitney U …

Standardization Of Patient Handovers From The Operating Room To The Surgical Intensive Care Unit: A Quality Improvement Project, Jacob S. Key

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Patient handovers from operating rooms (ORs) to intensive care units (ICUs) frequently endure communication breakdowns and poor staff satisfaction when standardized handover procedures (SHPs) are not in place. Purpose: The project’s purpose was to assess the impact of a SHP checklist on OR to surgical ICU (SICU) handover staff satisfaction and perceptions regarding the patient handover process at a Level 1-designated trauma academic hospital. Interventions: Pre- and post-project staff satisfaction surveys were conducted after four months of SHP checklist introduction and utilization. Methods: SHP checklist and survey formation were based on similar quality improvement (QI) project designs revealed during …

Experimental And Theoretical Investigation On The Initiation Mechanism Of Low-Rank Coal's Self-Heating Process, Yinan Zhang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coal spontaneous combustion remains a safety concern during coal mining, transportation, and storage and requires further investigation to develop effective prevention and control strategies. While various intrinsic and extrinsic conditions may influence coal self-heating, low-rank coals are more prone to spontaneous combustion, especially in humid climates. Therefore, quantifying the effect of extrinsic moisture on the self-heating of low-rank coals is critical for understanding the high propensity of low-rank coals for spontaneous combustion. Many studies have qualitatively evaluated the role of extrinsic moisture on the coal self-heating. Despite this, few studies have quantified the contribution of extrinsic moisture on wetting and …

A Novel Computational Network Methodology For Discovery Of Biomarkers And Therapeutic Targets, Qing Ye

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lung cancer has the second highest cancer incidence rate and the top cancer-related mortality worldwide. An estimate from the American Cancer Society shows that, in 2022, there will be about 236,740 lung cancer cases (117,910 men and 118,830 women) in the US. To date, there are no prognostic/predictive biomarkers to select chemotherapy, immunotherapy, and radiotherapy in individual non-small cell lung cancer (NSCLC) patients. There is an unmet clinical need to identify patients with early-stage NSCLC who are likely to develop recurrence and to predict their therapeutic responses. This dissertation developed a novel computational methodology for modeling molecular gene association networks …

Developing An Evaluation Process For Telehealth In A Copd Clinic, Jodi H. Biller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Telehealth was broadly implemented as a care modality in response to a worldwide pandemic in 2020. Before the COVID-19 pandemic, while telehealth was not new, it was not widely utilized at the project site location, and a uniform method of evaluating its effectiveness was needed. This quality assurance project developed and piloted a uniform process to evaluate telehealth in a Chronic Obstructive Pulmonary Disease (COPD) clinic, then evaluated stakeholder perceptions about the process used in developing the evaluation tool.

Methods: The telehealth evaluation tool was developed using the National Quality Forum (NQF) framework and Global Obstructive Lung Disease (GOLD) …

Development Of A Machine Learning Model To Characterize The Performance Of A Selective Catalytic Reduction On Filter After-Treatment System For A Heavy-Duty Diesel Engine, Samuel A. Okeleye

Graduate Theses, Dissertations, and Problem Reports (ETD)

Particulate matter (PM) and Oxides of Nitrogen (NOx) are the major pollutants in diesel engines, an attempt to control one leads to an increase in the other, a phenomenon known as PM-NOx trade-off in diesel engine emission control. Currently, these two pollutants are controlled by the Diesel Particulate Filter (DPF) and the Selective Catalytic Reduction (SCR) after-treatment system respectively, in addition to the Diesel Oxidation Catalyst (DOC) which helps to provide 1:1 split of NO/NO₂ and helps with raising exhaust gas temperatures. Today, heavy-duty diesel engines feature a DPF, a primary SCR and a secondary SCR. Despite this complex …

Assessment Of Electronic Cigarette User Terminology And Knowledge Using Mixed Methods, Margaret G. Childers-Kakos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electronic cigarettes (ECIGs) have evolved rapidly over the past several years, and it is unclear if terminology used when assessing ECIG knowledge and use behavior has objective and well-understood definitions between consumers, as well as between consumers and the research community. The purpose of this study was to use semi-structured interviews to obtain a better understanding of ECIGs from the perspective of regular ECIG users. One-hour interviews consisted of both open- and closed-ended questions. Questions probed the terminology used by participants to describe both individual and combination device features, as well as ECIG use behaviors. Qualitative data was used to …

Influences Of Disrupted Circadian Rhythms On Stroke Outcome, Jennifer A. Liu

Graduate Theses, Dissertations, and Problem Reports (ETD)

The circadian system is composed of a subset of temporal oscillators that function through a transcriptional and post-translational molecular and functional negative feedback loop cycling approximately every 24 hours. The central clock located in the suprachiasmatic nucleus is responsible for entrainment using light as the key timekeeper (zeitgeber); it is responsible for synchronizing and optimizing physiological behavior and function to the environment. Exogenous information, such as day length and light-dark cycles, provide critical temporal cues for adjusting to environmental conditions. Proper alignment to natural light dark cycles and circadian rhythms is optimal for vital health, fitness, and survival in organisms. …

Investigating The Interplay Of The Immune System, Skin Barrier, And Microbiome Following Dermal Exposure To Triclosan, Rachel Baur

Graduate Theses, Dissertations, and Problem Reports (ETD)

Triclosan is an antimicrobial chemical used in healthcare products that are applied to the skin. However, exposure to triclosan has been positively associated with food allergy, aeroallergy, and asthma severity in humans. In mice, dermal triclosan exposure, although not directly sensitizing, has been shown to augment the allergic response in a model of asthma. Furthermore, exposure to triclosan on mouse skin has been demonstrated to be immunomodulatory through the activity of thymic stromal lymphopoietin and S100 calcium-binding protein A8. The skin barrier and microbiome are known to interact with the immune system and disruptions in barrier integrity and the microbiome …

Ero1Α Promotes Tumorigenesis In Egfr Driven Nsclc, Brennan D. Johnson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Non-Small Cell Lung Cancer (NSCLC) is a pulmonary malignancy most commonly associated with smoking, or exposure to asbestos or Radon. Approximately, 1.6 Million deaths occur each year due to lung cancer. Lung Cancer is categorized by two main types, Small Cell Lung Cancer (SCLC) and NSCLC. NSCLC accounts for approximately 85% of all lung cancer cases and is subdivided into three sub-categories: Adenocarcinoma, the most common and leading cause of death in the United States; Squamous Cell Carcinoma (SCC), and Large Cell Carcinoma. Though NSCLC treatment regimens have shown increasing clinical benefit over the last two decades with targeted therapies. …

A Quality Improvement Initiative Regarding Ondansetron In The Prevention Of Spinal Anesthesia-Induced Hypotension, Kassidy Dell Nutter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Spinal anesthesia is an excellent choice as the primary anesthetic for lower abdominal, perineal, and lower extremity procedures. Spinal anesthesia boasts several distinct advantages over general anesthesia. However, it is important to note that spinal anesthesia does not come without risk. The most common adverse reaction of spinal anesthesia is hypotension. Anesthesia providers use several methods to combat the hypotension that is so commonly associated with spinal anesthesia. One emerging trend to prevent spinal anesthesia-induced hypotension (SAIH) is the administration of ondansetron, a serotonin 5-hydroxytryptamine3 antagonist. Evidence has shown that the administration of ondansetron just prior to spinal anesthesia administration …

Implementation Of An Advanced Training Program To Increase Nurses’ Knowledge Of Continuous Renal Replacement Therapy Management, Shane M. Brost

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Continuous renal replacement therapy (CRRT) is a complex, life-preserving treatment for unstable patients who require hemodialysis in the intensive care unit (ICU). Nurses responsible for managing the CRRT machine in this large academic medical center’s cardiovascular ICU (CVICU) complete a one-hour basic training course focused on setting up the machine, responding to basic alarms, and changing out the CRRT circuit when necessary. Staff nurses, advanced practice providers (APPs), and nursing administrators agree that training is insufficient. Research evidence supports rigorous staff training as essential to improving the quality of CRRT delivery. Purpose: This Doctor of Nursing Practice (DNP) project …

An Anesthesia-Based Quality Improvement Initiative To Decrease Opioid Administration Via Esmolol Administration, Fredrick J. Hanna

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Laryngoscopy and endotracheal intubation are routine procedures that occur within the surgical setting. Fentanyl is currently administered for attenuating the hemodynamic response to intubation. Opioid-sparing alternatives have been identified with aims of improving patient outcomes, such as esmolol. Purpose: The project’s purpose was designed to improve anesthesia provider familiarity, perception, and consideration of esmolol as a non-narcotic alternative for attenuating the hemodynamic response to intubation and prompt an increase of esmolol administration within this setting. Interventions: Surveys were conducted before and after an educational in-service, offered to anesthesia providers, demonstrating esmolol as an efficacious alternative to fentanyl. Additionally, an …

Integration Of Fisheries Ecology With The Assessment Of Microplastic Consumption In Black Bass In The Upper Ohio River Drainage, Kaylyn Zipp

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis explores the dynamics of microplastic consumption of black bass (smallmouth, Micropterus salmoides, largemouth, M. dolomieu, and spotted bass, M. punctulatus) in the Monongahela and Kanawha River and explores dietary characteristics in the Ohio, Monongahela, and Kanawha River. The first chapter serves as an introduction and synthesis of microplastic consumption, fisheries ecology, and regional information. The second chapter quantifies microplastic consumption in the Monongahela River and explores spatial variation within and between species by pool and seasonal effects. The third chapter consists of exploratory Quasi Poisson modeling of total microplastics in the Point Marion pool, Monongahela River, WV using …

Evaluating Muskellunge (Esox Masquinongy) Catch-And-Release Mortality At Elevated Summer Water Temperature, Ian Taylor Booth

Graduate Theses, Dissertations, and Problem Reports (ETD)

Angling for Muskellunge (Esox masquinongy) has become widespread and increasingly popular throughout the fish’s range. Current management strategies for Muskellunge include high minimum harvest lengths (>1016mm), closed seasons, and catch-and-release regulations. Due to these strategies and angler sentiments, up to 97% of Muskellunge caught today are released by anglers assuming they will live and be caught again in the future. Previous research on catchand-release mortality in Muskellunge has suggested relatively low mortality rates (0%-5%). However, these studies were all conducted within the fish’s thermal optimum and generally at water temperatures25°C during the summer months, representing a need to evaluate …

Preconception Substance Use And Risk Of Unintended Pregnancy, Saima Shafique

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: In the United States, unintended pregnancy is a serious public health issue due to its persistent high prevalence. In the series of three studies, our first two investigations examined the risk and potential determinants of unintended pregnancy among substance and polysubstance using women of childbearing age. In the third study, we conducted a systematic review (SR) with meta-analysis (MA) to assess the association of illicit and recreational drugs to the risk of unintended pregnancy.

Methods: We performed a secondary data analysis on a subset of Pregnancy Risk Assessment Monitoring System (PRAMS) 2016-17 phase 8 data (n=75,543). The outcome variable …

Factors Associated With Service Utilization In Injured Workers In West Virginia, Brandy Brown

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Minimal research has been conducted on healthcare utilization among injured workers residing in rural areas. These workers are often at high risk for work-related injury due to the industries in which they work and commonly experience barriers to accessing healthcare. The first study in this dissertation series explored general characteristics of injured workers receiving care at occupational medicine clinics in West Virginia (WV). The second and third studies explored the moderating effects of rurality, pain medication, and psychiatric medication on sociodemographic and health status factors and number of medical encounters.

Methods: Each study used a cross-sectional design with data …

Clitic Doubling: The Case Of Nariño Andean Spanish, Jessica Paola Jurado Eraso

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis examines the behavior of clitic doubling in Nariñense, a little-studied Andean Spanish variety spoken in the southwest of Colombia, and compares it to well-studied varieties such as standard Peninsular, Rioplatense, and other Andean Spanish varieties. Its aim is to present novel data about clitic doubling in order to shed more light into the extensive literature about this phenomenon in Spanish. Through spontaneous speech recordings obtained from thirty native speakers of Nariñense, 133 sentences involving clitic doubling were analyzed. Features such as agreement matching between the clitic and the doubled NP, use of the preposition a to introduce the …

The Vanishing Frontier: Economic And Social Change In Western North Carolina, 1945-1970, Elisabeth Avery Moore

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation works to integrate the growth of regional tourism into the existing historiography of economic development in Appalachia and the postwar American South. Regional leaders introduced an economic transition throughout western North Carolina that emphasized the growth of regional tourism. By centering this study on the growth of regional tourism, this research also analyzes regional boosters’ efforts to manufacture and commodify a racialized and classed folk culture within the region for tourist consumption. In the late nineteenth century, journalists and folklorists had emphasized the deviance of mountain life and simultaneously romanticized the area as a land of rugged, white …

Gender Leadership Imbalance In Sport Organizations In Latin America, Monica Yamile Gonzalez-Cuevas

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of the study was to examine gender imbalance at the leadership level of sport administration at National Olympic Committees (NOC), National Paralympic Committees (NPC), and National Sport Organizations (NSF) of countries members of the Pan American Sports Organization (PASO). Specifically, this study examined how social and human capital, socio-cultural aspects of each country, and power-based discourses affect the advancement of women’s careers at the micro, meso, and macro levels of analysis.

A total of 12 participants were selected to participate in this study. Participants were all female sport administrators holding the position of president, vice-president, or secretary-general of …

A Multi-Method Evaluation Of Parent And Child Factors Associated With Child Abuse Potential, Lindsay R. Druskin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Child abuse is a pervasive, global problem impacting millions of children (Stoltenborgh et al., 2015). Researchers have largely relied on the use of parent-report questionnaires to examine a variety of risk factors for child abuse (see Azar, 2002; Stith et al., 2009), leaving a gap in the research regarding the link between observed parent and child behaviors and child abuse potential. Utilizing a sample of families clinically referred for child behavioral problems, the proposed study pursued a multi-method approach to explore relations between parent factors (parent attachment, emotion regulation, harsh behaviors, and stress), child factors (child disruptive behaviors), and the …