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Characterizing 4,4’-Methylene Diphenyl Diisocyanate Exposure In Primary Human Epidermal Keratinocytes: A Multi-Omics Approach, Brandon F. Law

Graduate Theses, Dissertations, and Problem Reports (ETD)

Exploring the routes of exposure and biological fate of 4,4’-methylene diphenyl diisocyanate (MDI) has been a challenge for many years. Occupational exposure to MDI can result in the development of occupational asthma (MDI-OA) which results in loss of productivity, large economic costs, and costs to the individual worker. Initially, it was thought that respiratory exposure to MDI was the most likely route leading to MDI-OA. Industries utilizing MDI have been successful at controlling airborne concentrations according to industrial hygiene assessment and newly diagnosed cases of MDI-OA decreased and plateaued. New research suggests that dermal exposures to MDI may explain this …

Pilot Quality Improvement Project To Update Surgeon Preference Cards Of A Community Hospital's Orthopedic Service, Jessica R. Mitchell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Implementation of a Pilot Quality Improvement Project to Update Surgeon Preference Cards

of a Community Hospital’s Orthopedic Service

Jessica R. Mitchell

Problem Statement: Over time, surgeons change preferences for surgical equipment, and their preference cards need updating. Failure to update preference cards leads to impaired staff communication, opening of unnecessary equipment, excess waste, increased cost to patients and facilities, and potential threats to patient safety.

Background: Members of the orthopedic surgical team in a community hospital in suburban West Virginia wanted to establish a process to regularly update outdated surgeon preference cards (SPC) for several common orthopedic procedures. The …

Genetic Knowledge And Causal Beliefs: Implications For Health Behavior In Clinical And Non-Clinical Samples, Jamey T. Brumbaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objective: As the genomic era in healthcare continues to surge, it is vital to examine genetically-related psychological concepts, such as genetic knowledge and genetic causal beliefs, in genetically relevant clinical groups. Parents /caregivers of children born with cleft lip and/or palate represent a population whose knowledge and beliefs about genetics may be influenced by their frequent utilization of genetically-related healthcare services (e.g., genetic testing and genetic counseling). To date, little is known about how such beliefs vary across disease types. Even less is known regarding how disease-specific genetic causal beliefs relate to perceived behavioral control for disease development. Method: A …

The Role Of Synaptic Zinc Signaling In Excitatory Circuits Of The Mouse Auditory Cortex, Philip T R Bender

Graduate Theses, Dissertations, and Problem Reports (ETD)

Synaptic zinc signaling modulates synaptic activity and is present in specific populations of cortical neurons, suggesting that synaptic zinc contributes to the diversity of intracortical synaptic microcircuits and their functional specificity. The pool of chelatable synaptic zinc is controlled by the zinc transport protein ZnT3, a protein which functions by moving free zinc into glutamatergic presynaptic vesicles, from which it is co-released with glutamate during synaptic transmission. Once synaptic zinc is released within the synaptic cleft, it acts on glutamate receptors on the post-synaptic spine, including ionotropic NMDA and AMPA receptors. While the inhibitory function of zinc on NMDA receptors …

Taking The Red Pill: A Content Analysis Of Ambivalent Sexism And Precarious Manhood In Alpha Male Podcasts, Madalen Lea Fields

Graduate Theses, Dissertations, and Problem Reports (ETD)

Podcasts have become increasingly popular across various platforms (e.g., Spotify or Apple podcasts). A more recent trend is the emergence of “alpha male” podcasts. The goal of these podcasts is to instruct young men how to stop being “betas” and on achieving “alpha male” status. These podcasts are a subset of the manosphere, a term used to describe media focused especially on hegemonic masculinity, which is characterized by their promotion of misogynistic beliefs and sexist rhetoric. Drawing upon social science research, three forms of sexism (i.e., ambivalent sexism, precarious manhood and violence against women) serve as analytical frameworks for understanding …

Life Cycle Impacts Of Hardwood Forest Resources For Sustainable Bioenergy And Bioproducts In The Eastern United States, Jinghan Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

A life-cycle impact assessment of hardwood resources across the eastern United States was conducted based on the life-cycle inventory data for hardwood forest resource management and was integrated with the Forest Vegetation Simulator (FVS). This integration allowed for the analysis of forest carbon dynamics in the four subregions: northeast (NE), mid-Atlantic (MA), southeast (SE), and northcentral (NC). The system boundary was selected to be consistent with the A1 module (extraction and upstream production) required by an Environmental Product Declaration (EPD) for wood products. The results indicated that uneven-aged management (UA) yielded higher carbon stocks than even-aged management (EA) across all …

Low Power Remote Sensing System For Ceramic Thermocouples, Syed Khaleduzzaman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ceramic thermocouple sensor is a promising alternative to traditional thermocouple due to their corrosion resistance and cost-effective manufacturing. Currently, no electronic Interface or Integrated Circuit solution is commercially available which can be used to interface these thermocouples at low-cost and low power for accurate temperature measurement. An electronic system is needed to use these ceramic sensors which consumes less amount of power for an extensive period of time with remote monitoring option.

This thesis proposes a low-power electronic remote sensing system that works for ceramic thermocouples. The system consists of three parts. They are battery-operated sensor node electronic circuit, …

Examination Of The Time Course Effects Of Electronic Cigarettes On The Thoracic Aorta, Madison Robinson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Endothelial dysfunction is a critical early marker of the pathogenesis of cardiovascular disease and a pathological biomarker in cigarette smokers. Emerging evidence finds similar cardiovascular risks resulting from electronic cigarettes (E-cig) as that seen from smoking. Logically, the time or length of exposure to E-cigs will likely influence the development of vascular dysfunction, however, the length of exposure that causes permanent damage is unknown. The goal of this study was to determine the potential window of chronic E-cig exposure that results in vascular dysfunction, which is marked by endothelial dysfunction, microvascular dysfunction, and stiffening of arteries. Based on prior chronic …

Experimental And Chemical Modeling Of Applied Dc Electric Field Induced H2 – Air Axisymmetric Laminar Co-Flow Diffusion Flames With Low Carbon Impurities, Susith Dilshan Pathmasiri Gunamuni Halowitage

Graduate Theses, Dissertations, and Problem Reports (ETD)

The effect of externally applied DC electric fields on flame structure was investigated in a stationary atmospheric axisymmetric laminar H₂–Air flame with less than 100 ppm carbon equivalent impurities. Flame OH chemiluminescence signals were recorded using a UV-sensitive CCD array as a function of voltage (+10 to -10 kV) applied to a stainless-steel ring electrode placed around the burner nozzle. Changes in chemiluminescence signal are reported as a function of electrode height above the burner, airflow, and fuel composition. Significant changes in OH* distributions were observed for voltages below -5 kV. Under optimum conditions, the height of the …

Testing A Conceptual Model Of Age, Gender, Perceived Discrimination And Well-Being, Kelly Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Both age and gender are personal characteristics that are at least in part outwardly visible and act as a category for social judgments (Cuddy & Fiske, 2002). The current study examined associations among individuals’ views on their aging, their gender typicality, well-being, and perceived discrimination. Research Question 1 asked whether views on aging and gender typicality interact to influence perceptions of discrimination; Research Question 2 explored the same potential interactions’ influence on well-being. Research Question 3 explored whether any interaction between views on aging and gender typicality and well-being was mediated by perceptions of discrimination. Participants represented the adult life …

Development Of Dynamic Mass-Energy-Thermodynamics Constrained Hybrid Neural Network Models For Process Systems Applications, Angan Mukherjee

Graduate Theses, Dissertations, and Problem Reports (ETD)

First-principles models can provide very good predictions even for cases when there are no data at all, or data are limited in certain range of operating conditions, or for cases where data collection is infeasible. However, the development of accurate first-principles models for complex nonlinear dynamic systems can be time consuming, computationally expensive, and may be infeasible for certain systems due to lack of sufficient knowledge (information). It is also challenging to adapt first-principles models for time-varying systems. Furthermore, it can be difficult, if not impossible, to develop accurate models for some complex phenomena that are poorly understood. On the …

Spatial Degradation And Livelihood Diversification In The Ever-Changing Landscape Of Pastoralist Kajiado, Kenya, John A. Paine

Graduate Theses, Dissertations, and Problem Reports (ETD)

The study centers on both internal and external pressures on Maasai communities, such as environmental changes and socio-economic shifts, all of which are rapidly changing. It further examines the historical colonial context in Kajiado that has led to spatial degradations - a decline in an objective geographic area's function, usage, or ecological health. Such degradation has taken on different forms based on varying cultural, environmental, and livelihood-centered understandings and motivations. Understanding this is particularly important to investigation of how the cultural identity of the Maasai shapes realities and informs decisions about livelihoods. This idea is especially relevant when, out of …

State Estimation And Economic Analysis For Electrochemical Sensor-Based Corrosion Monitoring, Chandra Sekhar Somayajula

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coal is currently the third-largest source of electricity production in the U.S. However, renewables are projected to be the primary source of electricity production in the future. Though coal-fired power plants (CFPPs) are rapidly retiring in the U.S., many CFPPs worldwide are expected to stay operational for a while due to factors like easy and cheap access to comparatively inexpensive coal. Therefore, non-renewable sources like coal are still expected to be prevalent and be used to ensure the stability of the electric grid in the foreseeable future. The existing coal-fired power plants generally designed to operate at base-loaded conditions are …

Extracting Meaning: Museums, Power, And Shaping The Story Of Coal, Danielle Marie Petrak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Organized into four case studies, this dissertation investigates how longstanding power relationships in the Central Appalachian coalfields have shaped the preservation and presentation of mining history at museums and historic sites. It contributes to scholarship in the fields of public history and Appalachian history by exploring how apolitical, noncritical, and biased narratives at mining history sites have obstructed the public’s acknowledgement of larger forces and systems that govern Appalachian society and often bring harm and misinformation to coalfield residents. To present more exhaustive, nuanced, and innovative interpretations of bituminous coal mining’s past and present, museums and historic sites must redirect …

Subjective Cognitive Decline: Examining The Contributions Of Adverse Childhood Experiences And Social Determinants Of Health, Amber Victoria Rusch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Subjective cognitive decline is one’s awareness of their own consistent memory loss or confusion that interrupts their day-to-day activities (CDC, 2022; Roehr et al., 2017). Several risk factors for subjective cognitive decline, such as demographic social determinants of health (SDOH) and adverse childhood experiences (ACEs) have been identified through previous research (Alzheimer’s Association, 2016; Dening & Sandilyan, 2015); however, less is known about the interaction between demographic SDOH and ACEs on subjective cognitive decline. The current study sought to examine how demographic SDOH (i.e., age, sex, race, and education) (research question 1) and ACEs (i.e., physical abuse, sexual abuse, and …

The Relationship Between Moral Thought-Action Fusion And Scrupulosity Across Judaism, Christianity, And Islam, Kelsey Evey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Scrupulosity is a subtype of obsessive-compulsive disorder (OCD) where individuals are upset by intrusive thoughts related to religious or moral issues. Current research suggests that scrupulosity occurs across the major world religions—including the Abrahamic religions (i.e., Judaism, Christianity, and Islam). Some research suggests that moral thought-action fusion (moral TAF), a dysfunctional belief that thinking something is equal to doing it, may only be pathological under certain circumstances (e.g., if it is not culturally normative). If this is true, the current cognitive model of scrupulosity may need to be amended to reflect how cultural differences impact the role of moral TAF …

Implementation Of The Academic Autistic Spectrum Partnership In Research And Education (Aaspire)-Based Guidelines To Improve Perioperative Care Of Patients With Autism Spectrum Disorder, Kayleigh Brink

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Implementation of the Academic Autistic Spectrum Partnership in Research and Education (AASPIRE)-based Guidelines to Improve Perioperative Care of Patients with Autism Spectrum Disorder

Kayleigh Brink

Introduction: Autism Spectrum Disorder (ASD) is becoming more prevalent with an increasing need to identify and eliminate barriers to care. Healthcare Providers (HCP) have shown limited knowledge and confidence when managing patients with ASD. The inability to provide specialized care and recognize symptoms of pain or discomfort could result in behavioral difficulties.

Purpose: The purpose of this project was to improve confidence among HCPs to identify ASD characteristics and to improve the use of …

Self-Efficacy And Parental Miscarried Helping In Adherence And Transition Readiness Among Adolescents And Young Adults With Epilepsy, Kirby-Estar G. Laguerre

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Given the complex regimen associated with epilepsy, ensuring that adolescents and young adults (AYAs) adhere to their medications, and are ready to transition from pediatric to adult care, is crucial to optimizing their health outcomes. Several social and ecological factors such as self-efficacy and parental miscarried helping can strengthen or weaken an adolescent’s medication adherence and readiness to shift from pediatric to adult care. Intending to contribute to informing and improving clinical care, this study sought to understand the relationships between self-efficacy, parental miscarried helping, medication adherence, and transition readiness. Methods: Using a cross-sectional observational design, 46 AYAs with …

Parental Socialization Of General And Domain-Specific Self-Control In Adolescents, Matty Johnston

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adolescent self-control appears to be an important competency to develop. It has pervasive links with various outcomes (e.g., educational, financial, and interpersonal) both during adolescence and into adulthood (Allemand et al., 2019, Moffitt et al., 2011). Adolescents often report lower self-control compared to adults, although individual levels of self-control vary widely between adolescents (Allemand et al., 2019, Romer et al., 2010). Despite its importance, very little is known about how self-control develops. Thus, the current study aims to examine the relationship between parents’ self-control and that of their teen children. To further understand how adolescents' self-control may be socialized by …

Factors That Influence Plans To Have Children: An Application Of The Theory Of Planned Behavior To Fertility Decision-Making Across The Reproductive Years, Amanda Chappell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Fertility intentions include plans to have one or more children; intentions can be used to predict fertility behavior. The focus of the current study was to examine the influence of age and gender on factors involved in estimating fertility intentions (measured with 5 items), including attitudes (i.e., how one feels about becoming a parent; 13 items), norms (i.e., pressure from important others to have children; 5 items), and perceived control (beliefs about capability of becoming a parent; 4 items) in a U.S. sample. The study included a sample of N = 289 (51% men) participants (75.6% White) between the ages …

Intervention To Reduce Tobacco Use Among Prostate Cancer Patient And Informal Caregiver Dyads, Trupti Dhumal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Prostate cancer is the leading cancer in men. Continued tobacco use after prostate cancer diagnosis may affect a patient’s treatment outcomes, quality of life, and mortality. Despite the potential negative outcomes, 10-20% of prostate cancer patients continue to use tobacco after their cancer diagnosis. Considering risks associated with continued tobacco use, there is a lack of evidence-based tobacco cessation strategies to address tobacco cessation specifically in prostate cancer. Given the increasing prevalence of prostate cancer, the ongoing difficulty in tobacco cessation, and the limited evidence-based tobacco cessation interventions in the literature, it is important to prioritize reducing tobacco use in …

Seeing Red: Hostile Attribution Bias, Aggression, And Antisocial Personality Disorder Traits, Kaley Potter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Antisocial personality disorder (ASPD) is a destructive and severe mental illness that costs the U.S. trillions of dollars annually. Although ASPD is significantly correlated with acts of aggression, violence, and imprisonment, not all individuals with ASPD are aggressive. In samples without ASPD, increased aggression has been linked to an error in social information processing, which is referred to as hostile attribution bias (HAB).

The current study tested the extent to which HABs, or the tendency to attribute hostility to neutral or ambiguous stimuli, predicted aggression above and beyond ASPD traits in participants with a history of incarceration. Participants (N = …

Effects Of Dietary Supplementation Of A Blend Of Saccharomyces Cerevisiae, Multiple Live Probiotic Bacteria, And Their Fermentation Products On Performance, Health, And Rumen Bacterial Community Of Newly Weaned Beef Steers During A 56-D Receiving Period, Emily Treon

Graduate Theses, Dissertations, and Problem Reports (ETD)

We examined the effects of a blend of Saccharomyces cerevisiae, multiple live probiotic bacteria and their fermentation products on performance, health, and the ruminal bacterial community of newly weaned beef steers during a 56-day receiving period. Forty newly weaned Angus crossbred steers (221 ± 25.6 kg BW; 180 ± 17 d of age) were stratified by body weight into four pens (10 steers per pen) such that each pen had a similar average body weight at the beginning of the experiment. The pens were randomly assigned to receive a corn silage basal diet (CON; n = 20) or the …

The Relationship Between Social Justice Attitudes And Compassion In Preservice Teachers: A Critically Compassionate Intellectualism Framework, Megan Hut

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation aims to gain further knowledge about the implementation of the Critically Compassionate Intellectualism (CCI; Cammarota & Romero, 2003) framework in teacher education. This framework, originally developed to provide a better education for Latine students who were being silenced in their original schools, emphasizes authentic caring, critical pedagogy, and social justice content. CCI aims to provide students with an education that better equips them to be part of our democratic society and is supposed to lead to an increase in students’ critical consciousness through developing compassionate relationships and making content related to students’ experiences. Based on the success of …

A Legacy Of Labor: Maternity Narratives In 1960s And 1970s North American Life Writing, Katelynn Ann Vogelpohl

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

A Legacy of Labor: Maternity Narratives in 1960s and 1970s North American Life Writing

Katelynn Ann Vogelpohl

The phenomenon of maternity has been repeatedly described as an event that shakes the very foundations of social and physical identity. As the flesh of the pregnant person literally divides to produce new life, one subject becomes enclosed within another, dramatically affecting the pregnant person’s sense of self and causing a confluence of intense, and often conflicting, feelings. In North America, there are two dominant, and seemingly opposing, discourses on pregnancy and childbirth: the institutional medical discourse and the natural childbirth discourse. …

Comparative Cephalometric Study Between Class Ii Patients Treated With Herbst Appliance And Patients Treated With Mara, Mona Meky

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Comparative cephalometric study between Class II patients treated with Herbst appliance and patients treated with MARA

Mona Meky, D.D.S.

Background and Objectives: Functional appliances have been used for over 100 years in orthodontics to correct Class II malocclusions. The Herbst and the MARA appliances have different designs that may enhance mandibular growth. Recent clinical evidence has questioned whether they really have a lasting influence on facial growth and that the effects of these appliances were mostly dentoalveolar rather than skeletal. The objective of this retrospective comparative study was to compare the dental and skeletal changes between Class II division …

Rural Student Postsecondary Decision-Making: Navigating Narratives Of The Purpose And Value Of Higher Education, Ashley Renee Leggett-Bradley

Graduate Theses, Dissertations, and Problem Reports (ETD)

The narrative surrounding the purpose and place of higher education has shifted dramatically over the past few decades, despite the persistent perceptions of the necessity of an educated society. With these shifts and conflicting narratives comes the question of how students are influenced by these narratives as they make their postsecondary decisions. This study seeks to illuminate the unique way that rural students receive, understand, and are influenced by these potentially conflicting narratives through a qualitative multi-site case study. All three sites are located within the North Central Appalachian portion of the state of West Virginia, and encompass a range …

Development And Application Of Functional Immune Assays To Understand Disease In Wild Smallmouth Bass Populations, Cheyenne R. Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over recent decades, the scientific community has observed a disconcerting trend – a decline in the health and stability of smallmouth bass (Micropterus dolomieu) populations across the Chesapeake Bay watershed with growing economic and ecological implications. Disease, declines, and death have been observed in multiple locations, particularly in the Susquehanna and Potomac drainages with the adults disproportionately affected in the Potomac River basin and young-of-year in the Susquehanna River basin. There has not been a single or consistent cause to the declines or mortality events. More likely, it is believed immunosuppression relating to a complex mixture of stressors has been …

Encouraging Equity Through Rural Elementary Professional Learning, Jana K. Stone

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study employed design-based research to explore the efficacy of professional learning materials and approaches in developing social justice advocacy with rural elementary teachers in Appalachia. Bronfenbrenner’s (2005) bioecological theory and Boler’s (1999) pedagogy of discomfort formed the theoretical framework for the design, implementation, and analysis. Mid-way through the study, Allport’s (1954) contact hypothesis was included to inform the revision of intervention approaches. Four elementary teachers attended seven in-person informational discussion meetings over five months. During this time, these teachers also read two books and completed journal responses and surveys. The qualitative data was analyzed using Braun and Clark’s (2006) …

A Test Of The Extended Theoretical Model Of Communal Coping Among Graduate Students: Investigating The Influence Of Communal Coping On Graduate Students’ Psychological Well-Being, Rebekah M. Chiasson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this dissertation was to test the extended theoretical model of communal coping (T. Afifi et al., 2020) in a graduate student sample by exploring predictors and outcomes of communal coping processes among 554 graduate students. The extended theoretical model of communal coping specifies that communal coping occurs when individuals within a community—such as graduate students within an academic program—perceive stressors as shared and are willing to take joint action to overcome those stressors. Results of this dissertation provided evidence that graduate students’ academic stress and the severity of individual academic stressors negatively impacted their psychological well-being. The …