Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Graduate Theses, Dissertations, and Problem Reports (ETD)

Discipline
Keyword
Publication Year
File Type

Articles 511 - 540 of 5148

Full-Text Articles in Entire DC Network

Investigating The Effect Of Using Humorous Threats In Recreation Area Rules Signage To Influence Behavioral Intentions, Jacob Timothy Vargas Jan 2024

Investigating The Effect Of Using Humorous Threats In Recreation Area Rules Signage To Influence Behavioral Intentions, Jacob Timothy Vargas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Communicating the importance of rules and warnings to visitors of recreational parks through signage can be difficult. However, it is one of the most important things to keep visitors safe. Oftentimes, these signs use fear of punishment or injury to discourage certain behaviors. According to studies following the Extended Parallel Processing Model (EPPM), using threats can backfire and cause visitors to use maladaptive fear responses to counteract a threat message if the content is too extreme or too psychologically close. Humor is a versatile tool that can be used to grab attention, temper perceptions, and influence decision-making. Comedians like Jon …


Development And Implementation Of Occupational Therapy Group Protocols For Individuals In Recovery For Substance Use Disorder: Considering Social Determinants Of Health And Occupational Areas Of Need, Samantha Jane Windisch Jan 2024

Development And Implementation Of Occupational Therapy Group Protocols For Individuals In Recovery For Substance Use Disorder: Considering Social Determinants Of Health And Occupational Areas Of Need, Samantha Jane Windisch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Substance use disorders (SUDs) are becoming a more widespread issue globally. According to the National Survey on Drug Use and Health, 19.7 million adults in the U.S. suffered from an SUD in 2017. (SAMSHA, 2018). Recurrent alcohol and/or drug use that results in significant disability, including health issues, and/or a failure to prioritize obligations like employment, school, or family life are characteristics of SUD (SAMHSA, 2022). Research suggests that healthcare providers must integrate cutting-edge and successful treatments for this population to lower the risk of overdose and relapse rates, given the swift global spread of addictive disorders. In the past, …


Women In Extension Persevering In Leadership Roles, Lexis Danielle Trickett Jan 2024

Women In Extension Persevering In Leadership Roles, Lexis Danielle Trickett

Graduate Theses, Dissertations, and Problem Reports (ETD)

Over the last several decades, the rates at which women have been pursuing higher levels of education have steadily increased. However, there is a discrepancy between the number of women graduating, and the amount entering the workforce, specifically in leadership roles. The purpose of this study was to share a current profile of women in the West Virginia Cooperative Extension Service by allowing them to describe their career journeys, supports and barriers they may or may not have faced, and mentoring experiences. By using a non-experimental quantitative methodology, a population of male and female Extension Agents and Specialists were surveyed …


An Integrated Framework For Establishing Long-Term Transportation Management Strategies Promoting Sustainable Urban Growth, M Imtiaz Rahman Jan 2024

An Integrated Framework For Establishing Long-Term Transportation Management Strategies Promoting Sustainable Urban Growth, M Imtiaz Rahman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Urban land areas are experiencing a more rapid expansion compared to their population growth on a global scale. This phenomenon, known as urban sprawl, is characterized by low-density development in the outskirts of cities. This unplanned urban growth leads to changing urban transportation patterns, posing a threat to sustainable development. In response, government agencies implement growth management practices, with transportation management strategies playing a crucial role in achieving sustainable urban growth. However, developing effective growth management strategies is difficult because of several challenges, including limited understanding of the key influencing factors, the complex interdependencies among these factors, and the uncertainties …


The Names Of All Wild Things: Field Guides And Environmental Thinking, Frank Izaguirre Phd Jan 2024

The Names Of All Wild Things: Field Guides And Environmental Thinking, Frank Izaguirre Phd

Graduate Theses, Dissertations, and Problem Reports (ETD)

The project first traces the earliest origins of natural history writing, surveying how natural history writing from antiquity presented and categorized the living world, and then how the rise of print culture and growing popularity of natural history writing would facilitate the rise of European empires. Values and conventions emerged that would later feed into the field guide, like the pairing of text and illustration to aid identification and the decontextualizing of plants and animals from their environments.

Near the end of the nineteenth century, the field guide genre emerged. Some wildly popular books, mostly written by women, emphasized the …


The Line Between Man And Monster: A Theatrical Costume Design Of Caryl Churchill's The Skriker, Katrina Anne Lundquist Jan 2024

The Line Between Man And Monster: A Theatrical Costume Design Of Caryl Churchill's The Skriker, Katrina Anne Lundquist

Graduate Theses, Dissertations, and Problem Reports (ETD)

Produced at West Virginia University, this is a record of the costume design process for The Skriker by Caryl Churchill. As a play about vicious folkloric faerie creatures in modern day England, there was a heavy emphasis on showcasing the difference between the human and fae characters. With such a fantastical script, there is a potential to take the design down any number of creative paths. Finding a way to cohesively costume the cast while not losing the intricacies of their individual stories became a personal priority. After coming to an agreement with the director and the rest of the …


Empowering Inclusive Mobility: Addressing Team Challenges And Advancing Solutions For Deaf Communities In Rural West Virginia Through Innovative Engineering And Collaborative Initiatives, Morgan Elaine Bartley Jan 2024

Empowering Inclusive Mobility: Addressing Team Challenges And Advancing Solutions For Deaf Communities In Rural West Virginia Through Innovative Engineering And Collaborative Initiatives, Morgan Elaine Bartley

Graduate Theses, Dissertations, and Problem Reports (ETD)

This report provides an overview of the strategic initiatives, challenges, and future considerations encountered by the West Virginia University (WVU) EcoCAR Team in their mission to enhance accessibility for deaf and hard-of-hearing individuals in rural West Virginia, with a specific focus on improving the Cadillac LYRIQ's features. The report delves into the stakeholder profile, encompassing demographic characteristics and mobility challenges unique to the target population, while also highlighting the team's SMART goals, key challenges faced, and forward-looking strategies to better the team.

The WVU EcoCAR Team's mission revolves around addressing mobility barriers for the deaf and hard-of-hearing community in rural …


Interactions Between Myeloid Cells And Neutrophil Extracellular Traps In Pancreatic Ductal Adenocarcinoma, Hillary Gabrielle Pratt Jan 2024

Interactions Between Myeloid Cells And Neutrophil Extracellular Traps In Pancreatic Ductal Adenocarcinoma, Hillary Gabrielle Pratt

Graduate Theses, Dissertations, and Problem Reports (ETD)

The 5-year-survival rate for pancreatic ductal adenocarcinoma (PDAC) is only 12% due in part to a lack of therapeutic strategies that target the pathophysiology of the disease. The only known curative therapy is surgical resection of the PDAC tumor, but only 20% of patients are eligible at the time of presentation. To improve outcomes for patients, new therapeutic options are needed. The PDAC tumor microenvironment (TME) is uniquely fibrotic and hypoxic, which is in part driven by the immune cell composition in the TME. Myeloid cells are a prominent immune infiltrate within the PDAC TME, so these cells have been …


Anamnesis, Kristian Thacker Jan 2024

Anamnesis, Kristian Thacker

Graduate Theses, Dissertations, and Problem Reports (ETD)

My work examines the duality of living in Appalachia and cherishing its picturesque environment; while being complicit in its ongoing destruction via industry and resource extraction. Composed of my own photographs and selections from the Farm Security Administration archives, this body of work presents a vision of the region that’s purpose extends beyond value judgments. Rather, it considers the manmade and natural environments of Appalachia holistically, each one integral to the experience and understanding of the other. Following the same aesthetic choices I make in my professional practice as a photojournalist, I blur the boundary between art and documentation. In …


Evaluating Outcomes Post-Adoption Of Reck Solution For Total Shoulder Arthroplasties: A Retrospective Quality Analysis, Benjamin Levi Tillis Jan 2024

Evaluating Outcomes Post-Adoption Of Reck Solution For Total Shoulder Arthroplasties: A Retrospective Quality Analysis, Benjamin Levi Tillis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Evaluating Outcomes Post-adoption of RECK Solution for Total Shoulder Arthroplasties: A Retrospective Quality Analysis

Benjamin Tillis

Introduction: Local infiltration analgesia (LIA) has become an integral part of postoperative pain relief for West Virginia University (WVU) Medicine’s total joint arthroplasty procedures. However, not all LIAs are the same. Liposomal bupivacaine has a unique mechanism of delivery which could potentially lead to longer lasting effects. Ropivacaine, epinephrine, clonidine, and ketorolac (RECK) solution offers a multimodal approach to enhancing the duration of effect for the LIA. In 2022, WVU Medicine switched from liposomal bupivacaine to the RECK solution for total joint …


“Population, Proximity, And Promise: A Study Of College Choice And The Competition For Students In Higher Education”, Donielle Maust Jan 2024

“Population, Proximity, And Promise: A Study Of College Choice And The Competition For Students In Higher Education”, Donielle Maust

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation is an empirical investigation of the relationship between institution and state characteristics and college choice for students enrolling out-of-state, as well as the relationship between Promise programs and college choice. The theoretical framework used in this study draws on both an economic model of human capital investment and sociological concepts of habitus, cultural, and social capital, and organizational context and assumes that an individual’s college choice is shaped by four contextual layers: the individual’s habitus, school and community context, the higher education context, and broader social, economic, and policy context. Public data from the Integrated Postsecondary Education Data …


Ecological Planning And Design For Creating A Thriving Suburban Community In Lumberton, Nc, Maram Moushmoush Jan 2024

Ecological Planning And Design For Creating A Thriving Suburban Community In Lumberton, Nc, Maram Moushmoush

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of the project is to propose ecological planning and design techniques to create a thriving and robust suburban community in Lumberton, North Carolina. The project becomes an educational hub on agroforestry, ecological design and stewardship, and flood mitigation through stormwater strategies for Linkhaw’s Mixed Use Community Development plan. Linkhaw Farms is a 540 acre site, in a predominantly Native American community, situated on the north-east boundary of Lumberton in the Coastal Plains region of NC. It was formerly owned by the Linkhaw family for over 70 years, producing tobacco, and later rotation of annual crop production between corn …


Childhood Adversity And Sexual Risk Taking In College: Pathways Through Alcohol Use, Sarah Josephine Miller Jan 2024

Childhood Adversity And Sexual Risk Taking In College: Pathways Through Alcohol Use, Sarah Josephine Miller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Exposure to adverse childhood experiences (ACEs) is associated with a host of negative outcomes throughout the lifespan including engagement in health-risk behaviors such as sexual risk taking and alcohol consumption (Dube et al., 2006; Negriff et al., 2015; Zaso et al., 2021). Additionally, sexual risk-taking and alcohol use commonly co-occur (Certain et al., 2009; Downing-Matibag & Geisinger, 2009). This may be especially true during the transition to college, in which many young adults have increased access to substances, increased autonomy, and an expanded network of peers. Thus, the present study examined the relationship between ACEs, alcohol use, and sexual risk …


Factors Related To Adolescent Anger In Appalachia: Implications For Violence Prevention, Rosalina Mills Jan 2024

Factors Related To Adolescent Anger In Appalachia: Implications For Violence Prevention, Rosalina Mills

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background. Adolescent health outcomes are vitally important for public health. One such outcome includes adolescent violence, a persistent and prevalent public health issue in the United States. Adolescent violence in rural areas is particularly understudied and some measures of rural violence are underreported compared to violence metrics in urban areas. A key risk factor for adolescent violence, is anger. By examining known key risk factors for adolescent anger through a primary prevention and socioecological perspective, it may be possible to reduce or prevent downstream violence in adolescence and later adulthood. Identifying specific systemic, environmental, and interpersonal factors related to anger …


Benefits And Barriers Of Using Prefilled Precedex Syringes In The Operating Room: A Cost Comparison, Ashley White Jan 2024

Benefits And Barriers Of Using Prefilled Precedex Syringes In The Operating Room: A Cost Comparison, Ashley White

Graduate Theses, Dissertations, and Problem Reports (ETD)

According to a report published by the Institute of Medicine, at least 44,000 and possibly up to 98,000 Americans die each year because of medical errors in hospitals. More than 7,000 of those deaths are from medication errors alone (Stucki et al., 2013). Anesthesia providers in the operating room (OR) are at even greater risk to commit medication errors due to their easy access to medications and their autonomy to make independent choices for medication administration. A small rural community hospital in Pennsylvania lacks a protocol for Precedex preparation. Evidence-based research show the benefit of prefilled ready-to-administer syringes, but the …


A Podcasting Series On The Historical Event Of Hawk’S Nest Tunnel Disaster, Hannah G. Morgan Jan 2024

A Podcasting Series On The Historical Event Of Hawk’S Nest Tunnel Disaster, Hannah G. Morgan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This professional project will look into the Hawk’s Nest Tunnel Disaster – a disaster that was birthed due to extreme capitalism and exploitation during the 1930s. This project will explore historical documents, books and interviews with those who are passionate about the event. With that research material, I will produce an educational narrative podcast with a cohesive storyline detailing the event, including a beginning, middle and end. The podcast series will be uploaded to Apple Podcasts and Spotify. This professional project can be replicated and used for other similar projects.


4d Epr Oximetry Imaging For 4d Bioprinting And Tissue Engineering, Sajad Sarvari Jan 2024

4d Epr Oximetry Imaging For 4d Bioprinting And Tissue Engineering, Sajad Sarvari

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioprinting, akin to 3D printing, employs cell-laden hydrogels such as GelMA (Gelatine Methacrylate) and Alginate instead of plastic or resin to create biological structures. The printing process followed by subsequent tissue maturation is known as 4D bioprinting, where the fourth dimension is time. Ensuring adequate and consistent oxygen, O2, supply within 3D bioprint volume over the entire maturation period process is crucial, as even transient hypoxia can impact cellular behavior and phenotypes. However, printing of fully developed vasculature remains an unresolved technical challenge. Several approaches to chemically (peroxides) or biologically (photosynthesis) generate oxygen during bioprint maturation have been proposed. However, …


Implementation Of A Pilot Quality Improvement Project To Guide The Administration Of Intraoperative Dexamethasone For Postoperative Nausea And Vomiting Prophylaxis In Patients With Diabetes Undergoing Orthopedic Procedures, Brittany W. Hall Jan 2024

Implementation Of A Pilot Quality Improvement Project To Guide The Administration Of Intraoperative Dexamethasone For Postoperative Nausea And Vomiting Prophylaxis In Patients With Diabetes Undergoing Orthopedic Procedures, Brittany W. Hall

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: At a local tertiary care hospital, there was no recommendation to guide anesthesia providers in the administration of intraoperative dexamethasone to patients with diabetes. While dexamethasone is a highly effective antiemetic, it may promote hyperglycemia in patients with diabetes.

Purpose: The purpose of this project was to guide and educate about current recommendations for the administration of dexamethasone for PONV prophylaxis in patients with diabetes.

Intervention: 1) Examined pre-intervention practices of dexamethasone administration. 2) Educated about current and best practices to anesthesia staff. 3) Developed badge buddy cards outlining the guideline. 4) Examined post-intervention practices. 5) Evaluated the effect …


Biology And Ecology Of Neonectria Magnoliae And Neonectria Punicea, Two Understudied Neonectria Species In West Virginia, Hannah Marie Petronek Jan 2024

Biology And Ecology Of Neonectria Magnoliae And Neonectria Punicea, Two Understudied Neonectria Species In West Virginia, Hannah Marie Petronek

Graduate Theses, Dissertations, and Problem Reports (ETD)

The family Nectriaceae includes numerous phytopathogenic fungi that cause canker diseases on both angiosperm and conifer hosts worldwide. Numerous Neonectria spp. cause cankers on hardwoods and conifers in North America, but their roles in contributing to tree decline and mortality outside of beech bark disease are largely understudied. One such pathogen, Neonectria magnoliae, causes perennial cankers on two native hosts in central Appalachia: Fraser magnolia (Magnolia fraseri) and tulip-poplar (Liriodendron tulipifera). We also recently confirmed N. magnoliae from non-native star magnolia (Magnolia stellata) in West Virginia. Both native hosts occur in the central …


Sexual Identity And Homophily: The Powerful Role Of Sexual Identity For Romantic Partner Selection, Lee Thorpe Jr Jan 2024

Sexual Identity And Homophily: The Powerful Role Of Sexual Identity For Romantic Partner Selection, Lee Thorpe Jr

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation investigates the role of sexual identity on homophily, and its effects on romantic partner selection. The principle of homophily states that individuals tend to befriend and seek romantic partners who are most similar to themselves based on certain social characteristics (i.e., birds of a feather flock together). The majority of the homophily literature focuses on heterosexual friendships and coupling. Recently, homophily research has included sexual identity in their analyses. However, recent studies have only investigated friendship formation/bonds for lesbians and describing certain racial coupling types for individuals based on their sexual identity. I fill the lacuna in research …


Short Episodes But Fast Friends: Examining The Effects Of Parasocial Relationship Quality On Mediated Intergenerational Contact In Grace And Frankie, Alysse C. Baker Jan 2024

Short Episodes But Fast Friends: Examining The Effects Of Parasocial Relationship Quality On Mediated Intergenerational Contact In Grace And Frankie, Alysse C. Baker

Graduate Theses, Dissertations, and Problem Reports (ETD)

Building on the foundations of intergroup contact theory (Allport, 1954), the parasocial contact hypothesis (Schiappa et al., 2005), and Harwood’s Contact Space (2010), this dissertation advances the existing literature on how intergenerational contact with media characters can improve young adults’ willingness to engage with older adults. Specifically, this study examines the effects of intergroup contact quality on the parasocial contact process. Episodes of the TV sitcom about older adult women, Grace and Frankie, were edited to create both a high contact quality condition and a low contact quality condition. The high contact quality condition was a montage that showed viewers …


Cleaning And Characterization Of Chemical Vapor Deposited Graphene For Nanoelectronic Device Development, Sakib Ishraq Jan 2024

Cleaning And Characterization Of Chemical Vapor Deposited Graphene For Nanoelectronic Device Development, Sakib Ishraq

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nanoelectronic devices based on graphene are a promising technology that combines the sensitivity and specificity of ion and element recognition with the accuracy and precision of electronics. The detection principle is based on the interaction of the target molecules with the nanodevice surface, which generates a measurable electrical signal. In the current study, graphene and its derivatives, synthesis and fabrication of high quality, good uniformity, and low defects graphene have been investigated as they are critical for high-performance and highly sensitive devices. Among many synthesis methods, chemical vapor deposition (CVD), have been used that needs to be transferred from the …


Influence Of Scaling And Root Planing With Minocycline Microspheres On Clinical Outcomes Of Patients With Periodontitis, Nupoor Sandeep Kulkarni Jan 2024

Influence Of Scaling And Root Planing With Minocycline Microspheres On Clinical Outcomes Of Patients With Periodontitis, Nupoor Sandeep Kulkarni

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Scaling and root planning (SRP) has been established as a “gold-standard” non-surgical initial treatment for periodontitis. Along with SRP, some systemic adjuncts like systemic antibiotics were used in the past to gain maximum benefits of SRP by reducing the need for further periodontal surgeries. Due to some drawbacks of systemic antibiotic use, like “transient antibiotic resistance”, “non-adherence” and “insufficient concentrations in the periodontal pockets to be clinically effective”, there was a shift towards the use of local antibiotic adjuncts to SRP like minocycline, tetracycline, chlorhexidine etc. Minocycline is a semi-synthetic tetracycline derivative which is available in a powder form, …


Clinical Significance Of Gutta Percha Variability, Alex R. Pancake Jan 2024

Clinical Significance Of Gutta Percha Variability, Alex R. Pancake

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The production of gutta percha points as root canal therapy filling materials vary from hand processing to machine processing with a range of acceptable levels of error (tolerance). Similarly, endodontic files manufactured to complement corresponding gutta percha points exhibit specified levels of tolerance. Investigations into the consistency among manufacturers of files and gutta percha points is limited. The aim of this study is to see how variability in apical gauge and taper of gutta percha points affected the clinical performance during cone try in. The null hypothesis of this study is that there is no difference in two gutta …


Slope Stability Below Historic Pre-Law Mine Benches In The Northern Coalfields Of West Virginia, Muhammad Ali Jan 2024

Slope Stability Below Historic Pre-Law Mine Benches In The Northern Coalfields Of West Virginia, Muhammad Ali

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Slope stability below historic pre-law mine benches in the northern coalfields of West Virginia

Muhammad Ali

Slope failures and landslides are commonly occurring geohazards in the state of West Virginia and in the Appalachian region due to weak geologic strata, steep slopes, a humid climate, geologically recent river incision, and human landscape modifications. Historic surface mining has resulted in large-scale landscape alterations. Surface mining conducted before the Surface Mine Control and Reclamation Act (SMCRA) of 1977 did not require reclamation to approximate original contour; as a result, remnant highwalls and mine benches are common throughout the state and region. …


Exploring Physical Activity Promotion And Implementation Within Inclusive Post-Secondary Education Programs: A Mixed-Methods Design, Shannon P. Zimmerman Jan 2024

Exploring Physical Activity Promotion And Implementation Within Inclusive Post-Secondary Education Programs: A Mixed-Methods Design, Shannon P. Zimmerman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adults with intellectual and developmental disabilities (IDD) exhibit lower physical activity levels compared to their non-disabled counterparts, with only 23% of U.S. adults with IDD engaging in the recommended 60 minutes per day of moderate-to-vigorous physical activity. Inclusive Post-Secondary Education (IPSE) programs in the U.S. offer an opportunity to promote physical activity and address the critically low physical activity levels. Few IPSE programs have formalized physical activity courses, warranting an evaluation and development of the national curriculum in this area. This study expands on previous work by examining current physical activity promotion strategies at both the program and course levels. …


Implementation Of Bayesian Statistics To Answer Diverse Engineering Questions: Applications In Cancer Immunology And Engineering Education, Anika C. Pirkey Jan 2024

Implementation Of Bayesian Statistics To Answer Diverse Engineering Questions: Applications In Cancer Immunology And Engineering Education, Anika C. Pirkey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Quantitative Systems Pharmacology (QSP) refers to a mechanistic modeling approach used for assessing potential therapeutics by linking the molecular and cellular level mechanisms of the disease and therapeutic to the system-wide dynamics and clinical endpoints relevant to the disease. Although the field of QSP is still in its relative infancy, the mathematical methodology employed to predict the kinetics of these systems are not new and can be applied to a wide variety of systems. For instance, similar to QSP’s goal of guiding the development of novel therapeutics for various disease states, there exists a need to develop novel interventions in …


A Quality Improvement Initiative To Reduce Preanalytical Blood Gas Errors, Layla Haver Newbrough Jan 2024

A Quality Improvement Initiative To Reduce Preanalytical Blood Gas Errors, Layla Haver Newbrough

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Introduction: Laboratory testing is one of the most commonly performed procedures in healthcare and resulting data are paramount to clinical decision making. Background: Preanalytical blood gas laboratory errors often stem from the incorrect recording of a patient’s fraction of inspired oxygen (FiO2) within the laboratory collection application. Incorrect FiO2 may cause erroneous results or delays in reporting results that have the potential to negatively impact patient safety and medical management.

Purpose: The purpose of this quality improvement initiative was to reduce the occurrence of preanalytical blood gas laboratory errors. Methods/Interventions: This initiative combined modification of the laboratory collection application …


Hepatic Mrna Expression Of Innate And Adaptive Immune Genes In Beef Steers With Divergent Residual Body Weight Gain, Deborah Ologunagba Jan 2024

Hepatic Mrna Expression Of Innate And Adaptive Immune Genes In Beef Steers With Divergent Residual Body Weight Gain, Deborah Ologunagba

Graduate Theses, Dissertations, and Problem Reports (ETD)

Immune system function is critical to maintaining the health and increasing productivity of cattle, affecting both their growth and their disease resistance. In an efficient immune system, the liver assumes an integral function in detoxification and metabolic processes and contributes substantially to overall production and immunity. In this study, we evaluated the hepatic mRNA expression of genes involved in innate and adaptive immunity in crossbred beef steers with either a positive or negative residual body weight gain (RADG). Positive-RADG beef steers (n = 8; RADG = 0.76 kg/d) and negative-RADG beef steers (n = 8; RADG = -0.64 kg/d) were …


Sex, Drugs, And Tbi: The Effects Of Sex Hormones And Trkb Activation On Alcohol-Related Behavior Following A Traumatic Brain Injury, Robin B. Oliverio Jan 2024

Sex, Drugs, And Tbi: The Effects Of Sex Hormones And Trkb Activation On Alcohol-Related Behavior Following A Traumatic Brain Injury, Robin B. Oliverio

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traumatic brain injury (TBI) and alcohol use disorder (AUD) exhibit a bidirectional relationship: AUD increases the risk of incurring a TBI and, inversely, a history of TBI increases the risk of future AUD. The second portion of this relationship has not been as thoroughly investigated. Our lab previously demonstrated that a juvenile TBI significantly increases alcohol self-administration in females compared to uninjured females and the injured females developed a conditioned place preference (CPP) for ethanol. Given this stark sex difference, this dissertation will examine the mechanism through which this occurred by investigating how manipulations of sex steroids might affect this …