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Design And Development Of A Novel Nanoparticle Aerosol Generation System For Research Applications, Justin R. Chambers
Design And Development Of A Novel Nanoparticle Aerosol Generation System For Research Applications, Justin R. Chambers
Graduate Theses, Dissertations, and Problem Reports (ETD)
Nanoparticles have become of great interest within the scientific community for their use in diverse applications. With this rapidly evolving field, new nano-sized compounds are being developed and used for a variety of reasons. Nanoparticle aerosol technology, aerosolization and dispersion of nano-compounds, has many novel applications and can be used to support current research efforts. This may include anything from drug delivery techniques to industrial processes. To aid these processes, new methods of aerosol generation and dispersion are needed to meet these future needs. This research and development is being conducted to expand upon a novel nanoparticle aerosol generator as …
A Multi-Agent Design For Smart Distribution Automation System With Distributed Energy Resources And Microgrids, Sridhar Chouhan
A Multi-Agent Design For Smart Distribution Automation System With Distributed Energy Resources And Microgrids, Sridhar Chouhan
Graduate Theses, Dissertations, and Problem Reports (ETD)
The proliferation of Smart Grid technologies such as distributed energy resources (DER) and microgrids has resulted in new opportunities and challenges to existing Distribution Automation (DA) solutions. A novel hybrid Multi-Agent System (MAS) Fault Location, Isolation, and Restoration (FLIR) solution is proposed for electric distribution systems with different types of distributed generation (DG) resources and microgrids. The main goal of the MAS is to locate and isolate the fault and then to automatically reenergize fault-free portions of the network to restore power to as many customers as possible while maintaining system constraints like voltage and thermal capacity limits.;Determination of the …
The Paganini Variations: A Study Of Selected Works By Liszt, Brahms, Rachmaninoff, Lutoslawski, And Muczynski, Youna Choi
Graduate Theses, Dissertations, and Problem Reports (ETD)
Caprice in A minor, Op. 1, No. 24 for solo violin by Niccolo Paganini has been a great inspiration for many composers. This study investigates five compositions that are based on the Paganini theme: Liszt, Brahms, Rachmaninoff, Lutos?awski, and Muczynski. Although these five composers utilized the same melodic material as their compositional source, their works are stylistically much different, from a typical nineteenth century idiom used by Liszt to the jazz-inspired harmony used by Muczynski.;Each chapter includes a general background and analytical aspects of the individual work, and is followed by performance guidelines. The performance guidelines not only deal with …
The Effects Of Conjugated Linoleic Acid And Berberine Supplementation On Markers Of Allopurinol Activated Oxidative Stress In Broiler Chickens, Vincent Dartigue
The Effects Of Conjugated Linoleic Acid And Berberine Supplementation On Markers Of Allopurinol Activated Oxidative Stress In Broiler Chickens, Vincent Dartigue
Graduate Theses, Dissertations, and Problem Reports (ETD)
Selection for rapid growth in poultry can be linked to an exaggerated state of oxidative stress (reactive oxidative species, ROS). Reactive oxidative species are kept in balance by endogenous and exogenous antioxidants. Two compounds, conjugated linoleic acid (CLA) and berberine (BRB) a purified compound from plant root extract have been suggested to ameliorate antioxidant activity. A ten week study examined the effect of CLA and berberine supplementation on markers of oxidative stress in poultry. Broiler chickens (n=60) were equally divided into six groups; a control, a CLA group where half of the regular oil used in a standard was substituted …
Novel Treatment Strategies For Brain Metastases Of Breast Cancer, Afroz Shareef Mohammad
Novel Treatment Strategies For Brain Metastases Of Breast Cancer, Afroz Shareef Mohammad
Graduate Theses, Dissertations, and Problem Reports (ETD)
About 20-40% of advanced breast cancer patients will develop symptomatic brain metastases. Once the patients diagnosed with metastatic brain tumors, there is 80% mortality rate within one year. The presence of blood-brain barrier makes it difficult for drugs to reach the site of action in brain-related ailments. To overcome we came up with two strategies: First, we encapsulated the chemotherapy in a liposome and thereby significantly improving the plasma pharmacokinetics of chemotherapy. We also observed that tumor drug exposure significantly improved by liposomal formulation. This improvement in plasma drug pharmacokinetics and tumor drug accumulation after administration of the liposomal formulation …
Evaluation Of Small Tree And Shrub Plantings On Reclaimed Surface Mines In West Virginia, Alexis Monteleone
Evaluation Of Small Tree And Shrub Plantings On Reclaimed Surface Mines In West Virginia, Alexis Monteleone
Graduate Theses, Dissertations, and Problem Reports (ETD)
Hundreds of acres of mined land are reclaimed annually in West Virginia (WV) and are planted with hardwood tree species. Forestry and wildlife post-mining land uses require the planting of specific tree species designated by the individual mine permit and planting plan, which generally includes planting of commercially-valuable hardwood species. Establishment and growth of fruit- and nut-producing small tree and native shrub species has not been studied for reforestation plantings on surface mines. Though these species are not generally planted as part of forestry reclamation, they are commonly found in forest ecosystems of WV and are often an important component, …
Examining Diabetes, Depression And Suicide In Middle-Aged And Older Adults, Kimberly Morton
Examining Diabetes, Depression And Suicide In Middle-Aged And Older Adults, Kimberly Morton
Graduate Theses, Dissertations, and Problem Reports (ETD)
Rates of suicide in the United States are highest in middle-aged and older adults compared to younger age groups. These rates are alarming and point to the need for suicide prevention research in middle-aged and older adult populations. Depression is the most well-established independent risk factor for death by suicide. Some health conditions are also associated with risk of suicide above and beyond depression. Diabetes is often co-morbid with depression (clinical and subclinical depression). However, research examining diabetes and risk of suicide is less clear. In the current study, the first aim was to examine diabetes, vision impairment and depressive …
Using A Species Distribution Model And Site-Specific Microclimatic Variables To Model Presence Of Spodic Soil Properties And Relative Occurrence Rate Of Picea Rubens (Red Spruce) To Inform Red Spruce Management, Adrienne Nottingham
Graduate Theses, Dissertations, and Problem Reports (ETD)
Red spruce restoration efforts in the central Appalachians are of interest to land managers because of the reduced current extent and the numerous ecosystem services provided by red spruce forests. These land managers require information regarding the best places to focus restoration efforts. Studies attempting to locate optimal locations for red spruce restoration have been conducted to in the central Appalachians, most of which utilize modeling. In particular, podzolization, a soil formation pathway present under conifer vegetation in the central Appalachians has been used to help select areas for red spruce restoration. The effectiveness of using recent podzolization (as evidenced …
Beyond Oraldigital: Ghanaian Electronic Literature As A Paradigm For African Digital Textuality, Kwabena Opoku-Agyemang
Beyond Oraldigital: Ghanaian Electronic Literature As A Paradigm For African Digital Textuality, Kwabena Opoku-Agyemang
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation speaks to a massive dearth of research in African electronic literature (African e-lit), a discipline that boasts a growing number of works but little scholarship. With African literature incorporating digital technology into its creative process, and with electronic literary criticism focusing on areas outside its predominantly western cannon, African e-lit positions itself as an important area of scholarly endeavor. After considering the implications of placing African e-lit as the direction in which both African literature and electronic literature take, this dissertation looks at three different genres of African e-lit in the context of oral literature. There are analyses …
Space Use And Habitat Associations Of Long-Distance Migratory First-Year Golden Eagles (Aquila Chrysaetos) From Interior Alaska In A Changing Landscape, Mark D. Paulson
Space Use And Habitat Associations Of Long-Distance Migratory First-Year Golden Eagles (Aquila Chrysaetos) From Interior Alaska In A Changing Landscape, Mark D. Paulson
Graduate Theses, Dissertations, and Problem Reports (ETD)
Understanding a species space use and habitat associations is integral to comprehensive wildlife management. Habitat associations change spatially and temporally and those changes may be especially dramatic for animals that cover long distances throughout their annual cycle. While many studies of habitat associations and space use concentrate on breeding season behavior, studies of migratory connectivity demonstrate how condition of habitats on non-breeding ranges potentially affect key demographic parameters, such as survival, reproduction, and movement in other seasons. This is also important because wildlife habitats, especially land cover, are changing rapidly from both anthropogenic and natural forces in direct and indirect …
The Effectiveness Of Video Education On Pre-Operative Parental Knowledge And Anxiety, Terri Marcischak
The Effectiveness Of Video Education On Pre-Operative Parental Knowledge And Anxiety, Terri Marcischak
Graduate Theses, Dissertations, and Problem Reports (ETD)
Pre-operative anxiety is a common and anticipated response to patients expecting to undergo anesthesia in preparation for surgery. Pre-operative parental anxiety can lead to increased anxiety in children, which is associated with physiologic alterations in the child. Pre-operative video education is an inexpensive method to increase knowledge and decrease pre-operative parental anxiety related to the perioperative process. The first goal of this project was to evaluate the effectiveness of a pre-operative video in increasing knowledge of the perioperative experience in parents of children anticipating surgery by viewing a pre-operative video. Parental knowledge was measured before and after viewing the pre-operative …
Proteomic And Metabolomic Analyses Of Biological Systems With Liquid Chromatography Tandem Mass Spectrometry And Ion Mobility Mass Spectrometry, Megan M. Maurer
Proteomic And Metabolomic Analyses Of Biological Systems With Liquid Chromatography Tandem Mass Spectrometry And Ion Mobility Mass Spectrometry, Megan M. Maurer
Graduate Theses, Dissertations, and Problem Reports (ETD)
Proteomic and metabolomic analyses provide information about altered metabolic processes in plants and animals. This information can be used to assess the impact of toxicant exposure or diseases on biological systems. In this dissertation, development of an ion mobility spectrometry - mass spectrometry (IMS-MS) strategy has been evaluated in addition to utilizing traditional liquid chromatography tandem mass spectrometry (LC-MS/MS) techniques for metabolite and protein analysis. Traditional LC-MS/MS techniques have been applied to the study of: 1) the molecular mechanisms responsible for altered microvasculature function as a result of pulmonary TiO2 exposure in rats; and 2) the effectiveness of intracerebroventricular (ICV) …
Role Of Perivascular Adipose Tissue In Vascular Pathology And The Therapeutic Effect Of Exercise, Evan Ray Devallance
Role Of Perivascular Adipose Tissue In Vascular Pathology And The Therapeutic Effect Of Exercise, Evan Ray Devallance
Graduate Theses, Dissertations, and Problem Reports (ETD)
Aortic compliance is important for dampening pulsatile flow and delivery of continuous flow to the periphery. Aortic compliance is regulated by extracellular matrix composition and endothelial derived nitric oxide. Disruption of aortic endothelium or extracellular matrix can lead to the development of aortic stiffness an independent risk factor of cardiac events and mortality. Over the past decade perivascular adipose tissue (PVAT) surrounding the vasculature has come to light as an important regulator of artery function. The main focus of this dissertation is to evaluate the role PVAT surrounding the aorta in mediating endothelial relaxation in health and disease. Specifically, metabolic …
Effects Of Differential Drl Exposure On Interval Timing: Information Vs. Inhibition, Matthew L. Eckard
Effects Of Differential Drl Exposure On Interval Timing: Information Vs. Inhibition, Matthew L. Eckard
Graduate Theses, Dissertations, and Problem Reports (ETD)
Recent investigations focusing on interventions to improve self-controlled choice have centered upon timing processes. However, speculation still remains regarding the mechanism of these interventions. To investigate how these interventions have their effects, timing in mice was assessed using an 18-s peak procedure (18-s FI trials; 54-s peak trials). During an intervention phase, mice in three treatment groups experienced differential reinforcement of low rate (DRL) schedules of reinforcement. A control group received continued exposure to the peak procedure. After 36 DRL sessions, timing was reassessed in the peak procedure. In contrast to previous reports, the DRL intervention resulted in less precise …
Child-Care Directors' Years Of Experience In Relation To The Activities Subscale Score On The Early Childhood Environment Rating Scale-R, Angelica Everetts
Child-Care Directors' Years Of Experience In Relation To The Activities Subscale Score On The Early Childhood Environment Rating Scale-R, Angelica Everetts
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study focused on examining the relationship between the child-care directors' years of experience in relation to the Activities subscale on the Early Childhood Environment Rating Scale-R. The data used in the study was from the Quality Rating and Improvement for West Virginia Child-Care grant, which was funded by the West Virginia Department of Health and Human Resources. The participants included 175 4-year-old classrooms across West Virginia. The Early Childhood Environment Rating Scale contains 43 items across seven subscales. This scale was used to measure the activities score of the 4-year-old classrooms. There was no significant relationship found between the …
Dual Targeting Of The Mesenchymal And Amoeboid Pathways: A Viable Therapy Against Metastatic Breast Cancer, Brandon C. Jones
Dual Targeting Of The Mesenchymal And Amoeboid Pathways: A Viable Therapy Against Metastatic Breast Cancer, Brandon C. Jones
Graduate Theses, Dissertations, and Problem Reports (ETD)
Metastasis from the primary tumor site is the major cause of death in breast cancer, and acquisition of migration capacity is a key element for successful metastasis. Recently, it was found that expression of NEDD9, a focal adhesion associated scaffolding protein, could be used to switch between two types of single cell movement known as mesenchymal and amoeboid. Control of this "switch" can potentially open up new avenues of treatment against cancer metastasis. Simultaneous inhibition of both types of single cell movement may prevent cancer migration, thus decreasing cancer spreading and increasing survival of cancer patients. For example, forcibly pushing …
High Touch, Andrew Kellner
High Touch, Andrew Kellner
Graduate Theses, Dissertations, and Problem Reports (ETD)
This written thesis is the supporting documentation for High Touch, my Master of Fine Arts thesis exhibition. The exhibition seeks to define my personal expression of beauty through domestic pottery that seeks to both elevate and celebrate mundane life experiences.;The research underpinning my thesis explores the connections between object and user. The use of pottery, particularly in the home, has the ability to breed familiarity, consolation, comfort and security. It is only when pots are put into service within the household that an affinity for the object is achieved and its unique character is revealed. These moments cannot be codified …
Ripple Effect Mapping Of Youth & Adult Dyad Pairs Demonstrating Community Impact From Icook 4-H Intervention, Sina J.E. King
Ripple Effect Mapping Of Youth & Adult Dyad Pairs Demonstrating Community Impact From Icook 4-H Intervention, Sina J.E. King
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: Creating effective dissemination and implementation tools within community based, obesity prevention research is needed to bridge the current science to practice gap. Ripple Effect Mapping (REM) using Community Capitals Framework (CCF) is a community impact evaluation tool that is hypothesized to positively capture activity during dissemination within community programs. Although REM is a proposed impact evaluation method, it has not been widely adopted within the research sector. In order to facilitate the translation of research into evidenced based practice, a stepwise process must be described and tested to determine efficacy and effectiveness, followed by a method to translate findings …
Evaluating Steam Conditioning Manipulations And Grain Expressed Enzymes Effects On Feed Manufacturing Metrics, Feed Hygiene, Broiler Performance, And Bone Mineralization, John William Boney
Evaluating Steam Conditioning Manipulations And Grain Expressed Enzymes Effects On Feed Manufacturing Metrics, Feed Hygiene, Broiler Performance, And Bone Mineralization, John William Boney
Graduate Theses, Dissertations, and Problem Reports (ETD)
Animal well-being, evolving feed manufacturing regulatory programs, and consumer perception drive the continued need to provide safe feed to animals. Considering the performance benefits associated with feeding pelleted feed, the concepts of hygienic feed production and production of highly durable pellets may interact to benefit the broiler chicken. In addition to hygienic and physical attributes, poultry nutrition may be enhanced by cereal grains expressing enzymatic activity. These additives may provide additional opportunities to support dietary phosphorus (P) requirements in growing broilers, further contributing to improved animal welfare conditions in an economically favorable manner. In order to study the effects of …
Novel Mechanisms Controlling The Expression Of The Antidiabetic Hepatokine Fibroblast Growth Factor 21, Kimberly M. Alonge
Novel Mechanisms Controlling The Expression Of The Antidiabetic Hepatokine Fibroblast Growth Factor 21, Kimberly M. Alonge
Graduate Theses, Dissertations, and Problem Reports (ETD)
The incidence of obesity has increased at an alarming rate during the past thirty years. Current therapies for the treatment and prevention of obesity and metabolic syndrome are ineffective and/or produce undesirable side effects. Fibroblast growth factor 21 (FGF21) is a liver derived hormone that mediates adaptive changes in hepatic glucose and lipid metabolism by elevating energy expenditure and reducing lipid storage. Pharmacological administration of FGF21 analogs in both animal and human models induces striking reversals of obesity and type 2 diabetes. However, the activity of FGF21 analogs exhibit short half-lives in blood circulation and are unsuitable for current treatment. …
Bioacoustics And Behavior Of American Crocodiles In Belize, Miriam Boucher
Bioacoustics And Behavior Of American Crocodiles In Belize, Miriam Boucher
Graduate Theses, Dissertations, and Problem Reports (ETD)
American Crocodiles (Crocodylus acutus) are large-bodied crocodylians broadly distributed throughout coastal and lowland wetlands in the Americas. Despite their being large, charismatic megafauna, the study of American Crocodile ecology is still lacking in many areas. As such we assessed the behavior and bioacoustics of American Crocodiles in Belize to address the paucity of data regarding these two facets of American Crocodile ecology. We conducted behavioral observations from three sites in the coastal zone of Belize. We categorized American Crocodile behavior and recorded activity duration for observed behaviors. In conjunction with behavioral data, we also assessed study sites to quantify the …
Carbon Dioxide Capture Using Amine Functionalized Carbonaceous Materials From Bio-Refinery Waste Streams, Emmanuel Atta-Obeng
Carbon Dioxide Capture Using Amine Functionalized Carbonaceous Materials From Bio-Refinery Waste Streams, Emmanuel Atta-Obeng
Graduate Theses, Dissertations, and Problem Reports (ETD)
One of the greatest challenges in the world today is to replace exhaustible fossil fuel resources with renewable alternatives that will satisfy the increasing worldwide energy and chemical demands in a sustainable way. Using renewable precursors has a low impact on environmental health since it reduces pollution, greenhouse gas emissions and limits global warming and problems associated with waste management. Lignocellulosic biomass is the most available feedstock for developing sustainable chemicals and energy. A major challenge to the efficiency of the forest biorefinery industry is lack of suitable technologies for the conversion of its waste or by-products (lignin and hemicelluloses) …
Interactions Between Euwallacea Ambrosia Beetles, Their Fungal Symbionts And The Native Trees They Attack In The Eastern United States, Matthew C. Berger
Interactions Between Euwallacea Ambrosia Beetles, Their Fungal Symbionts And The Native Trees They Attack In The Eastern United States, Matthew C. Berger
Graduate Theses, Dissertations, and Problem Reports (ETD)
In a globalized world, wood products are constantly being shipped from one location to another, along with tiny hitchhikers in the form of insects and microorganisms. Euwallacea validus is a fungus-farming ambrosia beetle native to East Asia that likely made its way to the United States in wood packaging materials in the latter half of the twentieth century. E. validus cultivates two fungal symbionts in the U.S., an unnamed Fusarium sp. (AF-4) and Raffaelea subfusca. Fusarium symbionts of Euwallacea ambrosia beetles as well as Raffaelea symbionts of closely related ambrosia beetles have incited widespread disease on more than one-hundred hosts …
Thermal Processes Associated With Pelleting And Feed Phosphate Variation In Diets On Feed Manufacture And Broiler Performance, Ariel N. Bergeron
Thermal Processes Associated With Pelleting And Feed Phosphate Variation In Diets On Feed Manufacture And Broiler Performance, Ariel N. Bergeron
Graduate Theses, Dissertations, and Problem Reports (ETD)
The objectives of the first study were to assess performance and digestible amino acid concentration of diets fed to broilers that differed in diet formulation and degree of thermal processing. Basal diets were corn, soybean meal, and DDGS based and formulations were balanced to be similar in calculated energy and digestible amino acids. Treatments were arranged in a 3 x 3 factorial that varied in diet formulation (Basal, Basal + Meat and Bone Meal (MBM), and Basal + Bakery Byproduct (BBP)) and degree of thermal processing (Unprocessed Mash, Pellet, Double Pellet). Pelleted treatments were steam conditioned and extruded through a …
Cholesterol Diet-Associated Changes In The Hippocampus - A Prelude To Alzheimer's Disease?, Sylwia W. Brooks
Cholesterol Diet-Associated Changes In The Hippocampus - A Prelude To Alzheimer's Disease?, Sylwia W. Brooks
Graduate Theses, Dissertations, and Problem Reports (ETD)
High serum cholesterol levels in midlife have been associated with an increased risk of developing Alzheimer's disease (AD) later in life. This thesis investigates a possible mechanism linking dietary cholesterol, which cannot pass the blood brain barrier, and AD-like hippocampal neuropathology. The first study tested the hypothesis that a high cholesterol diet increases the flux of the cholesterol metabolite 27-hydroxycholesterol (27-OHC) into the hippocampus. We found that a high-cholesterol diet increased levels of 27-OHC, a biologically active circulatory breakdown product of cholesterol, in hippocampal tissue. 27-OHC has been identified as an endogenous selective estrogen receptor modulator (SERM) that affects estrogen …
Supplementing Art Therapy With Cognitive Behavioral Therapy (Cbt) And Dialectical Behavior Therapy (Dbt) During Treatment Of Childhood Anxiety Disorders: A Pilot Study, Rachel Cecil
Graduate Theses, Dissertations, and Problem Reports (ETD)
A qualitative research study presents a thorough examination of one therapist's methods of supplementing art therapy with cognitive behavioral therapy (CBT) and dialectical behavior therapy (DBT) during the treatment of children impaired by a variety of anxiety disorders---i.e. generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PSTD). A review of the existing literature was used to inform the current study. The researcher created an exploratory case study, through the utilization of a pilot study, to gain a better understanding of the topic from an expert in these therapeutic fields. Through the gathering of data and analysis, the …
A Case Of The Mundanes, Nathan Ditzler
A Case Of The Mundanes, Nathan Ditzler
Graduate Theses, Dissertations, and Problem Reports (ETD)
This written thesis is the supporting documentation for A Case of the Mundanes, my Master of Fine Arts thesis exhibition. The exhibition seeks to give a visual presence to the seemingly trivial and overlooked moments of everyday life. It contains six individual sculptures made of handmade ceramic forms, fabricated mixed media elements, and modified found objects. The intention of A Case of the Mundanes is to combine nuances of humor to bring lightheartedness to the foibles and anxieties found in everyday life. The exhibition combines familiar and surreal representations to explore the way in which an artwork's meaning can shift, …
An Exploration Of The Relationships Between Chronic Pain, Inflammation, And Herbal Medicine, Termeh Feinberg
An Exploration Of The Relationships Between Chronic Pain, Inflammation, And Herbal Medicine, Termeh Feinberg
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: Inflammation is often a component of chronic pain, yet its potential role in fibromyalgia syndrome (FMS) remains inconclusive. FMS is a complex chronic pain condition affecting ~2% of the population; management is challenging and treatment options remain limited. Many herbs contain anti-inflammatory properties, and herbs indicated for analgesia and rheumatic conditions have traditionally been used in Appalachia. Despite the popularity of herbs in the US, determinants and patterns of herbal use with regard to pain management have not been well studied, particularly in Appalachia, where prevalence of chronic pain and related comorbid conditions is high and access to medical …
Diamond Bur Cutting Efficiency Of Dental Zirconia, Shelby Allison Alexander
Diamond Bur Cutting Efficiency Of Dental Zirconia, Shelby Allison Alexander
Graduate Theses, Dissertations, and Problem Reports (ETD)
Objectives: To monitor the rate of diamond bur cutting through sintered yttria stabilized zirconia. Through this observation, we intend to determine which bur(s) exhibit the greatest cutting efficiency and if a decline exists over time.;Methods: Seven dental diamond burs were used in an air-turbine hand piece to cut sintered Yttria Stabilized Zirconia blocks (3Y-TZP) at a constant 0.9N force for five minutes. The distance traveled was measured by a Linear Variable Differential Transformer (LVDT) and recorded per time by a data acquisition device. Time was divided into 100-second intervals for comparison. Individual effects of bur, time periods, and depth on …
Endocannabinoid Modulation Of Secretory And Inflammatory Causes Of Gastric Pathology, Molly S. Crowe
Endocannabinoid Modulation Of Secretory And Inflammatory Causes Of Gastric Pathology, Molly S. Crowe
Graduate Theses, Dissertations, and Problem Reports (ETD)
Non-steroidal anti-inflammatory drugs (NSAIDs) are common analgesic drugs that also cause well-known, negative gastrointestinal (GI) side effects. The specific physiological mechanism(s) of NSAID-induced GI damage are unknown, and are likely due to multiple causes. The most studied components include: increased gastric acid secretions, inflammation of the gastric epithelium, and increased gastric motility. Currently, proton pump inhibitor (PPI) antacids are used by chronic NSAID users, with the expectation that decreasing gastric acid output will reduce gastric epithelial irritation. However, PPIs are associated with side effects like infection, gastric polyps, and dementia. Therefore, new gastroprotective treatments that prevent NSAID-induced gastropathy are needed. …