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Graduate Theses, Dissertations, and Problem Reports (ETD)

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A Uses And Gratifications Analysis Of Consumer Satisfaction Correlated To Expectations In E-Commerce Retail Shopping., Stacey Ann Torjak Jan 2002

A Uses And Gratifications Analysis Of Consumer Satisfaction Correlated To Expectations In E-Commerce Retail Shopping., Stacey Ann Torjak

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research is an exploration of how retail is moving from the mall to the Internet. It applies uses and gratifications analysis of consumer satisfaction and ecommerce Web sites. The study compares obtained and sought after e-commerce consumer gratifications. The participants for the study attended West Virginia University in the spring 2002 semester. The study produced 50 valid responses that found consumers sought after gratifications for product display and navigation features were not met. This research also shows that experienced Internet consumers trust e-commerce Web sites privacy/security features. Implications for companies with e-commerce Web sites are explored.

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Personal Tobacco Use Behaviors And Tobacco Cessation Activities Of Dental And Dental Hygiene Students In United States Dental Schools., Amanda Suzanne Hatfield Jan 2002

Personal Tobacco Use Behaviors And Tobacco Cessation Activities Of Dental And Dental Hygiene Students In United States Dental Schools., Amanda Suzanne Hatfield

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to determine and compare the tobacco use behaviors of dental and dental hygiene students enrolled in U.S. dental schools with their perceptions and performance of tobacco use cessation counseling activities (TUCCA). A survey was mailed to a stratified sampling of accredited dental schools with which dental hygiene programs (n=8) were affiliated. Results were reported in frequencies, cumulative frequencies, and percentages. With use of the JMP program, Chi Square analyses were performed to test for statistical significance. Response rates of 57.1% from the dental programs (n=7) and 100% from the dental hygiene programs (n=8) were …

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The Induction Of Sensitization And Airway Hyperreactivity By 3-Amino-5-Mercapto-1,2,4-Triazole In A Murine Model., Kimberly Jean Klink Jan 2002

The Induction Of Sensitization And Airway Hyperreactivity By 3-Amino-5-Mercapto-1,2,4-Triazole In A Murine Model., Kimberly Jean Klink

Graduate Theses, Dissertations, and Problem Reports (ETD)

An increase in the incidence of respiratory disease reported in a herbicide producing factory correlates with potential exposure to 3-Amino-5-mercapto-1,2,4-triazole (AMT) and AMT based product 1 (AMT-bp1). In animal studies, no signs of systemic toxicity or irritancy were observed with concentrations up to 25% AMT or 40% AMT-bp1. AMT-bp1 was negative while a dose dependent increase was observed following exposure to AMT in the LLNA. An increase in B220+IgE+ cells was observed at 25% AMT exposure. AMT was negative in the MEST (up to 25%). Following dermal exposure 5 days a week, animals exposed to 25% AMT demonstrated elevated levels …

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A Model For Building A Better Academic Web Site: A Quantitative Analysis Of Foreign Language Departments On The World Wide Web., Margarita (Maria) M. Toro Jan 2002

A Model For Building A Better Academic Web Site: A Quantitative Analysis Of Foreign Language Departments On The World Wide Web., Margarita (Maria) M. Toro

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis defines what an effective academic web site is, and examines the utilization of web sites by the Land Grant colleges’ foreign language departments. A system with the parameters of evaluation was created from studies that observed web users’ perceptions of web sites. Four main factors were analyzed: informativeness, interactivity, entertainment, design and usability. The results showed that departments of foreign language are not projecting a positive image throughout their web sites. Moreover, the web masters of the foreign language departmental sites are not considering entertainment and interactivity features as fundamental elements in the development of academic web sites.

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An Investigation Into The Mechanism Of 2-Oxohistidine Formation From The Peroxidase Activity Of Superoxide Dismutase., Joseph Andrew Peters Jan 2002

An Investigation Into The Mechanism Of 2-Oxohistidine Formation From The Peroxidase Activity Of Superoxide Dismutase., Joseph Andrew Peters

Graduate Theses, Dissertations, and Problem Reports (ETD)

The pathogenesis of familial amyotrophic lateral sclerosis (fALS), a fatal neurodegenerative disease that sometimes results from SOD1 mutations, may involve the peroxidase reaction of the SOD1 protein. The aim of this thesis was to test the hypothesis that the peroxidase reaction of SOD results in SOD-centered peroxyl radical formation. The source of oxygen incorporated into 2-oxohistidine was to have been determined using HPLC/Mass spectrometry. This aim was not accomplished. UV-Visible difference spectrometry provided evidence for a peroxyl radical in this reaction. 2-oxohistidine formation was shown to be oxygen dependent and inhibited by the spin-trap MNP (Gunther, Peters, and Sivaneri 2002 …

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An Assessment Of Natural Cavity Abundance, Nest Box Use, And Management Recommendations For Birds On The Ohio River Islands National Wildlife Refuge, West Virginia., Karen A. Sacilotto Jan 2002

An Assessment Of Natural Cavity Abundance, Nest Box Use, And Management Recommendations For Birds On The Ohio River Islands National Wildlife Refuge, West Virginia., Karen A. Sacilotto

Graduate Theses, Dissertations, and Problem Reports (ETD)

Islands on the Ohio River contain valuable habitats that are unique and irreplaceable on a national or ecoregion basis. Aquatic habitats connected with the islands and their back channels (areas where commercial traffic is prohibited) provide quality habitats for bottomland hardwood wildlife; however, quantitative data on the importance of these areas are lacking. The objectives of this study were to: 1) compare breeding bird abundance and quality of habitat for cavity-nesting birds between back channel and navigational channel sides of islands, and 2) analyze the effects of nest box placement on cavity-nesting bird-use on the Ohio River Islands National Wildlife …

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Effects Of High -Dose Chemotherapy On The Bone Marrow Microenvironment, Brett Matthew Hall Jan 2002

Effects Of High -Dose Chemotherapy On The Bone Marrow Microenvironment, Brett Matthew Hall

Graduate Theses, Dissertations, and Problem Reports (ETD)

The bone marrow microenvironment composed in part of stromal cells provides the niche in which normal hematopoiesis occurs. Hematopoiesis generates cellular components of the immune system and blood through proliferation and differentiation of multipotent hematopoietic stem cells (HSC). In preparation for bone marrow transplantation, radiation or chemotherapy treatment temporarily disrupts the balance of hematopoiesis as many HSC and progenitor cells are destroyed. Following treatment cessation, transplanted HSC and progenitor cells migrate, or "home", back to the bone marrow microenvironment and initiate productive hematopoiesis. While the mechanism of bone marrow homing is not completely understood, several soluble factors and adhesion molecules …

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The Study Of Glucose-6-Phosphate Dehydrogenase (G6pd) Gene Regulation In Hepg2 Cells By Glucose Induction And The Study Of G6pd Mrna Localization By Fluorescent In Situ Hybridization (Fish)., Brian Nelson Griffith Jan 2002

The Study Of Glucose-6-Phosphate Dehydrogenase (G6pd) Gene Regulation In Hepg2 Cells By Glucose Induction And The Study Of G6pd Mrna Localization By Fluorescent In Situ Hybridization (Fish)., Brian Nelson Griffith

Graduate Theses, Dissertations, and Problem Reports (ETD)

HepG2 cells were used as a model system to study the regulation of glucose-6- phosphate dehydrogenase (G6PD). Regulation of hepatic G6PD expression involves changes in the amount of G6PD pre-mRNA in the nucleus in the absence of changes in the transcription rate of the gene. G6PD expression is increased in HepG2 cells incubated with increasing glucose concentrations. G6PD mRNA is increased 3- to 4- fold by incubation in 25 mM glucose, as compared to 0 mM glucose. To determine the cis-acting element involved in this regulation, HepG2 cells were stably transfected with G6PD genomic DNA composed of exons 7 through …

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Part 1: Structure, Stability And Reactivity Of Small Biologically-Active Organosulfur Compounds. Part 2: Generation Of Reactive Oxygen Species In The Enzymatic Reduction Of Chromium(Vi) And Arsenic(V) And Its Implications In Metal-Induced Carcinogenesis., Oluwarotimi Odunayo Olojo Jan 2002

Part 1: Structure, Stability And Reactivity Of Small Biologically-Active Organosulfur Compounds. Part 2: Generation Of Reactive Oxygen Species In The Enzymatic Reduction Of Chromium(Vi) And Arsenic(V) And Its Implications In Metal-Induced Carcinogenesis., Oluwarotimi Odunayo Olojo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Structure, stability, kinetics and mechanisms of oxidation of some important organosulfur compounds (2-aminoethanethiolsulfuric acid, 4-methyl-3-thiosemicarbazide and thionicotinamide) have been investigated by using UV-VIS, NMR, stopped-flow, and qualitative analysis. Results obtained showed that oxidation occurs mainly at the reactive sulfur center of the molecules via successive addition of oxygen atoms. The oxidation of thionicotinamide, an important xenobiotic, gave different oxygenated products, depending on the oxidizing power of the oxidant used. The sulfinic acid of thionicotinamide is stable with mild oxidizing agents while stronger oxidants desulfurize the molecule to yield sulfate as observed with other organosulfur compounds studied. Mechanism of oxidation leading …

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Gene Expression During Skeletal Muscle Development: Effect Of In Ovo Igf-1 Administration On Broiler Embryogenesis And Postnatal Myogenesis In The Mouse., Jennifer Jo Richter Jan 2002

Gene Expression During Skeletal Muscle Development: Effect Of In Ovo Igf-1 Administration On Broiler Embryogenesis And Postnatal Myogenesis In The Mouse., Jennifer Jo Richter

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Myogenic Regulatory Factor family (MRFs) is a family of transcription factors that plays a key role in the development of skeletal muscle. MRFs include Myo D, myf-5, myogenin, and MRF-4. Myo D and myf-5 are genes expressed during myoblast proliferation, whereas myogenin and MRF-4 are expressed during myotube formation and differentiation. Insulin-Like Growth Factor 1 (IGF-1) controls muscle development both embryonically and during postnatal growth and repair by inducing myoblast proliferation and muscle hypertrophy. We determined the mRNA expression patterns of the MRFs during muscle development of the chicken and the effect of recombinant human IGF-1 (rhIGF-1) on these …

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Building The Beaver And Lake Erie Canal: The Politics Of Public Improvements In Pennsylvania, 1783-1845., William David Mccarthy Jan 2002

Building The Beaver And Lake Erie Canal: The Politics Of Public Improvements In Pennsylvania, 1783-1845., William David Mccarthy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Patterns of commerce and settlement in colonial America were shaped by watercourses and portages. Road building skills were primitive and boating represented the most effective means of moving bulk freight and passengers. Traders and frontiersmen leading the advance of European settlement into the Appalachian Mountains therefore adopted the shortest crossings between watersheds. Natural conditions in Pennsylvania did not promote an orderly advance westward and produced isolated clusters of settlement around Philadelphia and Pittsburgh, with small and widespread settlements in Northwest Pennsylvania. State leaders were hard pressed to define the limits of Pennsylvania until the end of the eighteenth century, and …

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Land Use, Environmental Quality And Public Policy: Interactions And Implications For Agricultural Sustainability., Ramkumar Bendapudi Jan 2002

Land Use, Environmental Quality And Public Policy: Interactions And Implications For Agricultural Sustainability., Ramkumar Bendapudi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Population growth, combined with economic growth have been primary causes of urban sprawl and increased pressure on natural resources. Urban development often adversely affects land, water and air quality. Although not considered a threat to the nation's food production, land development and urbanization are critical issues because they can lead to fragmentation of agricultural and forest lands, loss of prime farmland, wildlife habitat and other resources, additional infrastructure costs for communities and regional authorities, and competition for water. These losses raise concerns about sustainability of land and agriculture. Various state-sponsored programs such as Purchase of Developmental Rights and Transfer of …

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The Impact Of A Language Learning Context On Chinese Students Learning English., Saundra Enany Faris Jan 2002

The Impact Of A Language Learning Context On Chinese Students Learning English., Saundra Enany Faris

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to examine English language acquisition in four ESL children whose native country is China. Each of the four children was considered individually and holistically through case study methodology, and some comparisons across children were considered. A second purpose of this study was to look holistically at the instructional strategies used to support language acquisition for each of these students. In addition, this research investigated the perceptions of the four Chinese ESL students regarding strategies and instructional methods used to facilitate English language acquisition at one or two elementary schools in a rural state in …

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The Significance Of Metallothionein Isoform 3 Gene Expression In Human Prostate Cancer., Rana Dutta Jan 2002

The Significance Of Metallothionein Isoform 3 Gene Expression In Human Prostate Cancer., Rana Dutta

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the expression of the brain specific metallothionein isoform, MT-3, was shown to be expressed in many, but not all prostate cancers, this gene was transfected into the commonly utilized prostate tumor cell line, PC-3, to study the consequence of MT-3 expression on growth rate and resistance to chemotherapeutic agents. PC-3 cells were stably transfected with MT-3 or MT-1E under control of the constitutive CMV promoter. The levels of MT-3 protein for the 5 overexpressing clones had an average level of 8.3 ng MT-3 per μg protein as assessed by quantitative immunodot blot analysis, and three were picked for further …

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The Relationship Between West Virginia School Principals' Self-Perceived Brain Hemispheric Cognitive Styles/Leadership Styles And Identified Schools Of Excellence., James Perry Varner Jan 2002

The Relationship Between West Virginia School Principals' Self-Perceived Brain Hemispheric Cognitive Styles/Leadership Styles And Identified Schools Of Excellence., James Perry Varner

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to identify the predominant self-perceived brain hemispheric cognitive styles and leadership styles of principals of schools identified as a West Virginia School of Excellence and to compare these with principals of schools that have not been identified as a West Virginia School of Excellence. The following research questions provided the focus for this study: Is there a difference between West Virginia principals of schools identified as a West Virginia School of Excellence and principals of schools not identified as a School of Excellence who perceive themselves as: (1) Right brain hemispheric cognitive style and …

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Order Effects Of Fear And Pain Induction, Kevin Erik Vowles Dec 2001

Order Effects Of Fear And Pain Induction, Kevin Erik Vowles

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although pain responding and emotional states such as fear are highly correlated and appear to interact, the causal relations between these variables have yet to be fully defined. This study sought to further illuminate these relations by investigating how exposure to one of these states (i.e., pain or fear) affects responding to the other. The order in which participants experienced fearful or painful stimuli was manipulated, as well as fear level (i.e., "low" & "high"). Measures of behavioral escape, heart rate, and verbal reports were obtained throughout four experimental trials, as well as rankings of aversiveness for all stimuli encountered. …

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Potential Relations Between Extraversion And Cardiovascular Reactivity During Laboratory Stressors, Brandie K. Taylor Dec 2001

Potential Relations Between Extraversion And Cardiovascular Reactivity During Laboratory Stressors, Brandie K. Taylor

Graduate Theses, Dissertations, and Problem Reports (ETD)

This present study was designed to examine the relation between cardiovascular reactivity to stress and the behaviors of individuals classified as either "extraverts" or "introverts." Although experimental psychophysiological studies have been conducted to examine the relation between extraversion and physiological arousal, little is known about the ways in which extraversion and cardiovascular reactivity to stress are related. According to the optimal arousal theory, both extraverts and introverts would be expected to be more reactive to a social challenge than to a mundane non-social task, with introverts exhibiting greater reactivity to both tasks than extraverts. In contrast, a preferred task model …

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Habitat Utilization And Movement Patterns Of Subadult Largemouth Bass (Micropterus Salmoides) In The Ohio River, Elizabeth Marie Hoffman Dec 2001

Habitat Utilization And Movement Patterns Of Subadult Largemouth Bass (Micropterus Salmoides) In The Ohio River, Elizabeth Marie Hoffman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ohio River electrofishing surveys identified embayments as preferred macrohabitat of subadult largemouth bass. Catch rates within macrohabitats were low ranging from 0.00--2.73 subadult bass/hour. Embayment electrofishing CPUE was higher than tributary or main channel except in spring, when tributary CPUE was highest.;Core use areas were calculated from biotelemetry data and ranged from 88--59,400 m2, representing 0.02--89.00% of available study location macrohabitat. Subadult bass movement was limited to nursery embayments or tributaries with infrequent movement to nearby main channel areas. Bass preferred a mixed microhabitat consisting of a combination of vegetation and woody debris. This mixed microhabitat was less common in …

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Prevalence Of Campylobacter In A Turkey Production Facility, Aaron Shawn Kiess Dec 2001

Prevalence Of Campylobacter In A Turkey Production Facility, Aaron Shawn Kiess

Graduate Theses, Dissertations, and Problem Reports (ETD)

Frequency of detection was monitored in three flocks of turkeys from May, 2000 to March 2001. The effect of time was considered for hens in flocks 1 and 2, and the effect of time, gender, and litter (fresh or used) was determined for flock 3. Poults, poult-box liners, waterers, and fecal droppings were monitered throughout production for the presence of Campylobacter using Campy-Cefex agar incubated at 42°C under microaerophilic conditions (85% N2, 10% CO2, and 5% O2). Peak colonization occurred near 3 weeks of production. Frequency of Campylobacter isolation from bird sources paralleled isolation from waterers. Frequency of detection from …

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Characterization And Quality Of Soils Developing On A Mountaintop Removal Coal Mine, Kevin Alfred Thomas Dec 2001

Characterization And Quality Of Soils Developing On A Mountaintop Removal Coal Mine, Kevin Alfred Thomas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mountaintop surface mining for coal has been practiced in West Virginia for over three decades, but its environmental impacts have become increasingly scrutinized in recent years. Therefore, this study evaluated soil development on different aged mined lands. Four different ages (2, 7, 11, and 23 years) of minesoils and two different slope classes, nearly level to gently sloping and steep to very steep, along with three contiguous native soils on a reclaimed mountaintop removal mine in Logan County, West Virginia were described and sampled. Standard analyses of physical and chemical properties were conducted in order to classify these soils. Some …

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Changes In Water Quality In Deckers Creek From 1974 To 2000, Jason Allen Stewart Dec 2001

Changes In Water Quality In Deckers Creek From 1974 To 2000, Jason Allen Stewart

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Deckers Creek drainage basin covers approximately 16,600 hectares (62.9 square miles) in Monongalia and Preston Counties of West Virginia. Throughout the twentieth century, this watershed has received high levels of pollution in several forms. A 1974 study examined the water chemistry in Deckers Creek over a six-month period at 29 sample points. Water samples from the same sites were collected and analyzed monthly from March 1999 through October 2000 for acidity, alkalinity, total iron, aluminum, manganese, and other metals, as well as for fecal coliform and fecal streptococcus concentrations. Most of the tributaries sampled in 1999--2000 showed reduced metal …

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Studies Of The Mammalian Ovarian Endothelin System, Marietta Felicidad Wright Dec 2001

Studies Of The Mammalian Ovarian Endothelin System, Marietta Felicidad Wright

Graduate Theses, Dissertations, and Problem Reports (ETD)

In porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in granulosa cells of large (10 mm) and medium (3 mm) antral follicles. This study, in conjunction with previous studies suggests a novel autocrine role of ET-1 as a possible local ovarian factor of follicular development. ET-1 may play a role during prostaglandin (PG) F2 alpha-induced luteal regression in the cow. Effects of PGF2 alpha treatment were examined during early and mid-luteal …

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Pest Management Practices Used By West Virginia Corn Growers, Leasa Dianne Wilkerson Dec 2001

Pest Management Practices Used By West Virginia Corn Growers, Leasa Dianne Wilkerson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to provide information that might be useful to researchers and extension personnel at West Virginia University in developing and designing educational programs concerning pest management for corn farmers. This research identified current trends in management practices, insect, fungal, and weed problems, and educational needs so that instructional materials can be designed to meet clientele needs. Data were collected via 100 questionnaires mailed to farmers in the top ten corn producing counties in West Virginia. Of these, thirty-three useable surveys were returned.;It was found that Gray leaf spot and Maize virus were the most prevalent …

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Parent-Infant Interactions During Acute Painful Procedures, Catherine Bradford Mcclellan Dec 2001

Parent-Infant Interactions During Acute Painful Procedures, Catherine Bradford Mcclellan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Despite the current recognition of infant procedural pain and distress, there is a dearth of research, both in the assessment and treatment literature, of infant procedural distress. This study examined how specific parent behaviors relate to infant procedural distress and whether this relation is mediated by birth order. Results indicated that females were rated as more distressed than were males, and that birth order did not prove to be a distinguishing factor in infant distress. Finally, while some behaviors appear to have a similar influence on both preschoolers' and infants' behaviors, parents' behavior during infants' distressing procedures were found to …

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Kinematic Synthesis Of A Well Service Machine, Prashanth Kaparthi Dec 2001

Kinematic Synthesis Of A Well Service Machine, Prashanth Kaparthi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Blowout preventers are used in the oil well industry to prevent accidental oil fires, and guide valves are assembled atop the preventers. The current solution is to use cranes, as this is time-consuming and expensive, a solution using an appropriate four-bar mechanism for this purpose was contemplated, using Burmester theory and the four-position synthesis method.;The angles and distance of the four positions were calculated and the data obtained was specified as input for the synthesis of the four-bar mechanism using four-position synthesis programmed in MATLAB(TM). The moving pivots (k) and the ground pivots (m) were obtained from the program and …

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Factors Affecting The Accumulation Of Pentosidine In The Skin Of Wild Birds, Richard Clair Chaney Jr. Dec 2001

Factors Affecting The Accumulation Of Pentosidine In The Skin Of Wild Birds, Richard Clair Chaney Jr.

Graduate Theses, Dissertations, and Problem Reports (ETD)

Birds have few reliable indicators of aging. Pentosidine (Ps), a biomarker of aging, is a product of non-enzymatic glycation, which accumulates in the tissues of an animal over its lifespan. The intent of this study was to determine if comparable change in Ps concentrations could be established in the skin of wild birds of known ages. Skin samples were obtained from the breast of 44 birds of various species. Foot webbing samples were obtained from 24 California Gulls. Collagen was measured by a hydroxyproline spectrophotometric method and Ps was quantified using reverse phase HPLC. Ps concentration in the skin and …

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Prenatal Stress Alters Fear-Conditioned Behaviors And The Response To Serotonergic Drugs, William C. Griffin Iii Dec 2001

Prenatal Stress Alters Fear-Conditioned Behaviors And The Response To Serotonergic Drugs, William C. Griffin Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic, inescapable stress during pregnancy (i.e. prenatal stress) modifies the behavior of the adult offspring. Several behaviors were evaluated in adult prenatally stressed (PS) rats, most notably the acoustic startle response and behavioral inhibition (i.e. freezing). PS rats do not differ in baseline peak startle responding, or in the habituation of the peak startle response when compared to the non-prenatally stressed (CON) rats. However, PS rats have greater peak responses and longer latencies to reach the peak response following systemic doses of the 5-HT 1A agonist, 8-OH-DPAT, compared to CON rats. The PS rats had shorter latencies than the CON …

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Transfer Of Heart Rate Feedback Training To Reduce Heart Rate Response To Laboratory Tasks, Jeffrey Louis Goodie Dec 2001

Transfer Of Heart Rate Feedback Training To Reduce Heart Rate Response To Laboratory Tasks, Jeffrey Louis Goodie

Graduate Theses, Dissertations, and Problem Reports (ETD)

Researchers have demonstrated that individuals can successfully reduce their heart rate (HR) response to a stressor when provided with heart rate feedback. However, it is unclear whether individuals can transfer HR reduction skills to stressors not used during HR feedback training. The present study used a multiple baseline, single subject design to examine the transfer of HR feedback training among six individuals. Participants were provided with HR feedback training during the presentation of a videogame, a mental arithmetic challenge, and a hand grip task until the participants reduced their HR to within 4 bpm of their resting HR or until …

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Mechanisms Of Retroviral Replication, Timur O. Kabdulov Dec 2001

Mechanisms Of Retroviral Replication, Timur O. Kabdulov

Graduate Theses, Dissertations, and Problem Reports (ETD)

Specific encapsidation of viral RNA is an essential step of retroviral replication cycle. Extensive biochemical and genetic analyses suggest that majority of retroviruses employ similar mechanisms for specific RNA packaging. Better understanding of mechanisms of this process may help to develop new anti-retroviral drugs against such serious pathogens as human immunodeficiency virus types 1 and 2.;This study concerns with specific packaging of RNA by two simple retroviruses, murine leukemia virus (MLV) and spleen necrosis virus (SNV). SNV proteins can package RNA of both SNV and MLV with similar efficiency. In contrast, MLV proteins cannot package SNV RNA. NC domain was …

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Pharmacological Regulation Of C-Myc Gene Expression In Human Breast Cancer Cells, Zaroui Karlen Melkoumian Dec 2001

Pharmacological Regulation Of C-Myc Gene Expression In Human Breast Cancer Cells, Zaroui Karlen Melkoumian

Graduate Theses, Dissertations, and Problem Reports (ETD)

Previous studies demonstrated that quinidine causes G1/G0 cell cycle arrest and inhibition of proliferation in MCF-7 human breast cancer cell line (Woodfork, K. et al., 1995). The goal of studies reported here was to understand the molecular mechanisms of c-myc gene regulation by quinidine. C-myc is one of the most common oncogene aberrations in breast cancers (Deming, S. L. et al., 2000). C-myc functions include regulation of cell cycle, proliferation, differentiation, and apoptosis. The results of these studies demonstrated that quinidine causes rapid (within 1 hour) suppression of Myc protein and mRNA levels that precedes the quinidine-induced G1 cell cycle …

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