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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Effect Of Increased Energy In A Restricted Diet On Bone Mineral Composition And Breaking Load Of Young Rat Tibias, Marcia Ann Romanchak May 2002

Effect Of Increased Energy In A Restricted Diet On Bone Mineral Composition And Breaking Load Of Young Rat Tibias, Marcia Ann Romanchak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Osteoporosis is a major health problem in the United States and those that are on energy restricted diets such as anorectic subjects. Thirty Wistar strain, young male rats were fed diets with varying quantities of fat for a period of four weeks (energy intake 67--75% of requirement). The rat tibias' physical properties were measured. Bone mineral composition testing was conducted for calcium, magnesium, and phosphorus, on the tibia shaft. There were no significant differences among the parameters of length, diameter, volume, density, bone bending (elasticity), fracture load, and minerals between experimental diets. There was a negative association between bending and …

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Comparison Of Herpetofaunal Species Composition And Response To Edge On The Camp Dawson Collective Training Area, Preston County, West Virginia, Amy B. Spurgeon May 2002

Comparison Of Herpetofaunal Species Composition And Response To Edge On The Camp Dawson Collective Training Area, Preston County, West Virginia, Amy B. Spurgeon

Graduate Theses, Dissertations, and Problem Reports (ETD)

Herpetofaunal species composition, abundance, and diversity were evaluated on the Camp Dawson Collective Training Area, Preston County, West Virginia, as a requirement of the Sikes Act (16 USC 670a et seq.), Army Regulation 200-3, and Department of Defense Instruction 4715.3. Herpetofauna were sampled using pitfall traps with drift fences and double-ended funnel traps, and also from area searches. Redback salamander (Plethodon cinereus), red-spotted newt (Notophthalmus v. viridescens ), eastern American toad (Bufo a. americanus), and wood frog (Rana sylvatica) were most common in pitfall arrays; mountain dusky salamander (Desmognathus ochrophaeus), Appalachian seal salamander (Desmognathus m. monticola), and redback salamander were …

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Retention Of Early Pregnancy And Its Relationship To Serum Progesterone In Dairy Cattle, Melanie J. Starbuck May 2002

Retention Of Early Pregnancy And Its Relationship To Serum Progesterone In Dairy Cattle, Melanie J. Starbuck

Graduate Theses, Dissertations, and Problem Reports (ETD)

Factors affecting pregnancy maintenance between 28 and 67 days of gestation were studied in dairy cows (N = 211). Beginning on day 28 to 37 post breeding, cows were examined by ultrasonography for a viable pregnancy. Pregnant cows were re-examined for pregnancy losses during the late embryonic (≤day 45) and early fetal stages up to day 67. Overall pregnancy loss was 11%, mostly occurring before day 45. Cows with two corpora lutea maintained fewer pregnancies than cows with one corpus luteum. Pregnancy retention was less when concentrations of progesterone were low during days 28 to 37. The embryo apparently died …

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Relationship Between Maternal Prenatal Vitamin Use And Infant Iron Status, Jennie Pringle Wilkins May 2002

Relationship Between Maternal Prenatal Vitamin Use And Infant Iron Status, Jennie Pringle Wilkins

Graduate Theses, Dissertations, and Problem Reports (ETD)

Subjects were fifty-six women and their infants who were between the ages of six months and twenty-four months. They were clients of Special Supplemental Nutrition Program for Women Infants and Children (WIC) clinics. The WIC clinics were in the West Virginia counties of Ritchie, Gilmer, Calhoun, Braxton, Mason, Jackson, Pleasants, and Greenbrier where the anemia rates were greater than 10%.;Information concerning WIC participation, prenatal vitamin use, history of breast feeding, infant birth weight, and pre-term delivery were obtained through questionnaires. Infants' serum ferritin level was obtained through venous blood and analyzed.;This ex post facto study found no significant result in …

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Microbial Ecology Of Freshly Sawn Yellow-Poplar Lumber ( Liriodendron Tulipifera L.) In Two Seasons, Mark Ryan Mikluscak May 2002

Microbial Ecology Of Freshly Sawn Yellow-Poplar Lumber ( Liriodendron Tulipifera L.) In Two Seasons, Mark Ryan Mikluscak

Graduate Theses, Dissertations, and Problem Reports (ETD)

Each year, the forest products industry sustains considerable product loss due to a reduction in market value of lumber brought about by microbial discoloration. The current practice of treating green lumber with chemical biocides to protect it from discoloration, although successful, is a potential hazard to both the environment and human life. One potential alternative to chemical biocides is biological control. The most recent success in the field of biological control has been achieved in the agricultural industry by first studying the microbial ecology of the substrate in which the biologically based preservative is to be used. Literature on microbial …

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Effects Of D -Amphetamine And Morphine On Behavior Maintained By Fixed -Interval Schedules, Jennifer L. Johnson May 2002

Effects Of D -Amphetamine And Morphine On Behavior Maintained By Fixed -Interval Schedules, Jennifer L. Johnson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The present experiments tested the effects of d-amphetamine and morphine on pigeons' responding during conventional and clocked FI schedules of food reinforcement. The first experiment compared performance between FI 5-min and continuously clocked FI 5-min components of a multiple schedule in which the rate of the houselight flashing increased in a continuous manner. The second experiment examined the differences between keypecking maintained by FI 5-min, response-dependent clocked FI 5-min, and response-independent clocked FI 5-min components of a multiple schedule. In the response-dependent clocked FI component, each peck produced a stimulus change that was correlated with the passage of time, while …

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Explaining Viking Expansion, Darrin M. Cox May 2002

Explaining Viking Expansion, Darrin M. Cox

Graduate Theses, Dissertations, and Problem Reports (ETD)

Current scholarship regarding Scandinavia has neglected to give all but a cursory glance at the factors involved in Viking expansion. This thesis studies and explains employment opportunities, political motives, and societal norms as separate, individual motives that perpetuated Scandinavian migration, conquest, and adventure from the eighth through the eleventh centuries AD. Afterwards, these investigations are used to describe the various and sometimes conflicting forces of expansion that led to the formation of the Danelaw in England circa AD 870. Over time, the eventual adoption of Christianity and feudal relationships within Scandinavia would bring expansion as well as the Viking Age …

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In Vitro Genotoxicity Investigations Of Jet Fuel, Shawna M. Jackman May 2002

In Vitro Genotoxicity Investigations Of Jet Fuel, Shawna M. Jackman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The 60 billion gallons of jet propulsion fuels consumed worldwide create an exposure situation to over two million military and civilian personnel per year. The potential mutagenic, genotoxic and cytotoxic potency of military jet fuel was investigated in this study through in vitro systems such as human peripheral lymphocytes and metabolically competent hepatic cell lines. A battery of genotoxicological evaluations is employed, focusing on the comet assay to examine the induction of DNA damage. Cellular exposures to fuel were carried out directly and indirectly with an ethanol (EtOH) carrier. The fuel was found to be nonmutagenic with and without metabolic …

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Insights Into The Nature Of Retroviral Replication And Infection: Analyses Of Minus-Strand Dna Transfer, Double Infection, And Virion And Rna Dimer Maturation., Que Dang Jan 2002

Insights Into The Nature Of Retroviral Replication And Infection: Analyses Of Minus-Strand Dna Transfer, Double Infection, And Virion And Rna Dimer Maturation., Que Dang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Retroviruses are a family of RNA viruses that replicate through DNA intermediates by reverse transcribing their genome. One of the essential steps of reverse transcription is minus-strand DNA transfer, during which nascent DNA switches template usage from the 5′ end to near the 3′ of the viral RNA genome. We have determined that minus-strand DNA transfer is homology driven; a minimum homology length is required to align the newly synthesized DNA with the 3′ RNA template to facilitate an efficient and accurate transfer. In addition to the obligatory template strand transfer events necessary to complete reverse transcription, template switching also …

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The Life And Keyboard Works Of (Franz) Xaver Scharwenka (1850-1924), Michael Patrick Mihalyo Jan 2002

The Life And Keyboard Works Of (Franz) Xaver Scharwenka (1850-1924), Michael Patrick Mihalyo

Graduate Theses, Dissertations, and Problem Reports (ETD)

(Franz) Xaver Scharwenka (1850-1924) was a highly acclaimed performer, teacher, editor, and composer of international fame during the late Romantic period. Overshadowed by the innovative styles of a number of contemporaneous composers including Ravel, Debussy, and Scriabin, Scharwenka's works gradually disappeared from the teaching studio and the concert hall. Regrettably, his compositions, although critically acclaimed in his lifetime, are now for the most part out of print and rarely performed. This study explores Scharwenka's works as a significant addition to the repertory of the late Romantic literature for study and performance. This research project, the result of a lengthy investigation …

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Hate Crime In The Media: A Content Analysis Of "The Washington Post" And "The New York Times"., Jennifer Michelle Hatcher Jan 2002

Hate Crime In The Media: A Content Analysis Of "The Washington Post" And "The New York Times"., Jennifer Michelle Hatcher

Graduate Theses, Dissertations, and Problem Reports (ETD)

In 1990, the United States Congress passed the Hate Crime Statistics Act (HCSA) which set into motion the development of a law-enforcement based data collection system aimed at learning more about “hate crimes.” By 1999 the term “hate crime” had become so widely used and recognizable that when news broke of the murders of Matthew Shephard, a University of Wyoming student who was brutally murdered because he was gay, and James L. Byrd, a disabled black man who was savagely murdered because of his race, the media understandably labeled these acts as “hate crimes.” In this paper the authors will …

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Costume Design For "The Emperor's New Clothes" By Charlotte Chorpenning., Kathleen Hoover Jan 2002

Costume Design For "The Emperor's New Clothes" By Charlotte Chorpenning., Kathleen Hoover

Graduate Theses, Dissertations, and Problem Reports (ETD)

This document records the costume design process for West Virginia University’s December 2000 production of The Emperor’s New Clothes. The costume design was produced and completed as partial fulfillment of the requirements for the Master of Fine Arts degree in Theatre Design, Costume. Contained herein are: a history of the play and playwright, critical reactions to the production, a synopsis of the action, an introduction to the design process with a concept statement, and text demonstrating the final costume designs with examples of the research, graphics, and performance photographs. Also included are a bibliography, an explanation of some important craft …

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Wheat, Wealth, And Western Maryland: The Growth And Evolution Of Flour Milling In Frederick County, Maryland, 1748-1789., John F. Kvach Jan 2002

Wheat, Wealth, And Western Maryland: The Growth And Evolution Of Flour Milling In Frederick County, Maryland, 1748-1789., John F. Kvach

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis explores the evolution of flourmills in Frederick County, Maryland within the context of the economic and social development of western Maryland from 1748-1789. Western Maryland’s development differed greatly from that of most other areas in Maryland. A large German immigrant population, along with English and Scottish settlers, settled the valleys, of present day Frederick County, during the eighteenth century. These settlers grew wheat and created a need for mills and millers. Economically, mills created prosperity by attracting new businesses and settlers to the frontier. Politically and socially, millers influenced a region often in conflict with the tobacco interests …

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Atmosphere: Transformation And Process., Jason Thomas Bohnert Jan 2002

Atmosphere: Transformation And Process., Jason Thomas Bohnert

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis document relays my graduate experience of discovering my voice in clay. My research involved the discovery of clay, glazes, and forms suited to my personal aesthetic as related to atmospheric firings and kiln experimentation. Developing my own expressions as pots based on my travels, culinary habits, and interactions with others and my natural environment was my goal. My work is heavily influenced by Chinese traditional pottery making techniques and tea culture. Many contemporary American potters have influenced my style, technique, and methodology as well. Merging traditions is of great importance to my work, allowing old traditions to live …

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Narrating Machines: Figurations Of Technology In "1 Henry Vi", "Robinson Crusoe", And "The Matrix"., Robert Patton Fanning Jan 2002

Narrating Machines: Figurations Of Technology In "1 Henry Vi", "Robinson Crusoe", And "The Matrix"., Robert Patton Fanning

Graduate Theses, Dissertations, and Problem Reports (ETD)

This essay attempts to demonstrate a tradition of the narrative use of technological tropes in Anglo-American popular narratives since the Renaissance. A play by William Shakespeare, a narrative by Daniel Defoe, and a recent movie are analyzed and compared to show the varying ways that technology has consistently figured in narrative attempts to address the contemporary social concerns narratively.

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Development Of Antibiotic Resistance Due To Chromosomal Mutation Caused By Ah26 Endodontic Sealer., Jason J. Hales Jan 2002

Development Of Antibiotic Resistance Due To Chromosomal Mutation Caused By Ah26 Endodontic Sealer., Jason J. Hales

Graduate Theses, Dissertations, and Problem Reports (ETD)

The endodontic resin sealer AH26® has been shown in multiple studies to have mutagenic potential. A unique test designed to identify phenotypic change in antibiotic resistance due to chromosomal mutation was described and performed. This test, modeled after the Ames test, used the Salmonella typhimurium (TA100) as the test organism. The test was divided into four phases. 1. Mutation Phase 2. Protein Expression Phase 3. Plate Incorporation 4. Evaluation of Antibiotic Resistance - changes in MIC values to ciprofloxacin, tetracycline & erythromycin identified with Etest®. The AH26® demonstrated a log-fold increase in mutant rate compared to the spontaneous mutant rate. …

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Women's Roles In Fairy Tales: A Comparison Of The Portrayal Of Women In "Marienkind" Of The Brothers Grimm And Benedikte Naubert's "Ottilie"., Astrid Munder Jan 2002

Women's Roles In Fairy Tales: A Comparison Of The Portrayal Of Women In "Marienkind" Of The Brothers Grimm And Benedikte Naubert's "Ottilie"., Astrid Munder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gender roles have always been and will always be, explicitly or implicitly, a topic of literature. The different ways in which gender roles are depicted in the literature of a given period reflect the political and societal state of affairs of that period. Literary works must therefore be critically analyzed to understand them in the context of their times. German fairy tales provide important examples of this. In this thesis I will examine the literary genre of the fairy tales in order to illustrate how differently female and male authors approached the topic of the woman’s role. To do so, …

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Progression Of Chronic Renal Disease In Several Animal Models: Possible Role Of Decreased Renal Nitric Oxide Production As A Primary Causative Factor., Aaron D. Erdely Jan 2002

Progression Of Chronic Renal Disease In Several Animal Models: Possible Role Of Decreased Renal Nitric Oxide Production As A Primary Causative Factor., Aaron D. Erdely

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic renal disease is the progressive loss of renal function that can lead to end-stage renal disease. Recent studies from our laboratory have shown decreased total NO production in patients with renal disease. Animal models have shown decreased total and renal NO production and chronic NOS inhibition in otherwise healthy rats causes renal injury. The overall objective in this set of studies was to investigate intrarenal NO production in various models of CRD and determine if NO deficiency parallels, and perhaps causes renal injury. In the first study, we report that normal male SD rats exhibit age-dependent declines in total …

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The Urotsa Cell Line As A Model Of Human Urothelium., Michael Ronald Rossi Jan 2002

The Urotsa Cell Line As A Model Of Human Urothelium., Michael Ronald Rossi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The UROtsa cell line is a unique model of human urothelium with considerable utility in toxicology-based research. UROtsa cells maintained in serum-free medium have several morphological features of transitional epithelium of the urinary bladder including a multilayered appearance and apically located umbrella-like cells that exhibit tight junctions. These cells also have a basal expression pattern of heat shock protein (hsp) and metallothionein (MT) genes similar to that observed in in situ urothelium. To characterize the functional heat shock and metallothionein stress response in UROtsa cells, confluent cultures grown in serum-free medium were treated with a variety of acute and chronic …

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The Effects Of Age On The Chromosomal And Physiological Integrity Of Human Sperm., Eddie D. Sloter Jan 2002

The Effects Of Age On The Chromosomal And Physiological Integrity Of Human Sperm., Eddie D. Sloter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Integrated biomarkers of physiologic and genetic damage in sperm are needed to identify factors that affect male fertility and influence a father's risk of producing abnormal progeny. Offspring studies show a preferential paternal origin for heritable structural chromosomal abnormalities, presenting the need for methods to efficiently detect structural chromosomal abnormalities in human sperm. This dissertation breaks new conceptual ground toward the understanding of paternally transmitted genetic disease by adapting FISH technology to detect human sperm that carry chromosomal breaks and partial chromosomal duplications and deletions and by integrating state-of-the-art biomarkers of semen quality including computer-assisted sperm analysis (CASA). These sperm …

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Differential Reinforcement Of Fixed-Interval Interresponse Times: Effects On Choice., Tammy Renee Wade Jan 2002

Differential Reinforcement Of Fixed-Interval Interresponse Times: Effects On Choice., Tammy Renee Wade

Graduate Theses, Dissertations, and Problem Reports (ETD)

Eight rats were exposed to a concurrent-chains procedure. Half of the rats chose between a fixed-interval schedule that required low rates of responding in the paced terminal link and a simple fixed-interval schedule in the unpaced terminal link. The other half chose between a fixed-interval schedule that required high rates of responding and a simple fixed-interval schedule. Interresponse-time criteria were based on the percentiles of a baseline distribution of interresponse times obtained for each rat. The criteria increased in stringency across conditions. Consistent changes in response rates as the result of the interresponse-time criteria were not obtained. Therefore, preference between …

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Landscaping The Lehigh: The Creation Of A Middle Industrial Landscape In Nineteenth-Century Pennsylvania., Augustine Nigro Jan 2002

Landscaping The Lehigh: The Creation Of A Middle Industrial Landscape In Nineteenth-Century Pennsylvania., Augustine Nigro

Graduate Theses, Dissertations, and Problem Reports (ETD)

Located sixty miles above Philadelphia, the Lehigh Valley follows the seventy-mile path of the Lehigh River as it descends from the Pocono Mountains south through the Blue Mountains into the rich agricultural lands of the Appalachian Great Valley. With anthracite deposits in its northern reaches, rich agricultural lands in its middle section, and commercial connections to Philadelphia at its mouth, nineteenth-century industrialists saw the river as a potential transportation route. From 1817 to 1829, the Lehigh Coal and Navigation Company developed a system of slack water navigation along the river. With the opening of the channel in 1829, extractive industries …

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Metal-Induced Generation Of Reactive Oxygen Species And Related Cellular Injury., Stephen Sunday Leonard Jan 2002

Metal-Induced Generation Of Reactive Oxygen Species And Related Cellular Injury., Stephen Sunday Leonard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Metals have been indicated in causing generation of reactive oxygen species (ROS) and cellular injury. The overall objective of the present study was to investigate ROS generation from metals and the related effects on biological systems. The results obtained from the present studies have demonstrated that: (a) Cobalt is capable of generating ·OH via a Co(I)-mediated Fenton-like reaction. (b) The ·OH radical is generated by reaction of H2O2 with Cr(V), which is produced by enzymatic one-electron reduction of Cr(VI). H2O2 is produced by reduction of molecular oxygen via O2·− as an intermediate. The ·OH radicals generated by these reactions are …

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The Effects Of Diet And Weight On Induction Of Puberty And Fertility Response In Yearling Beef Heifers., Quinn Stephan Baptiste Jan 2002

The Effects Of Diet And Weight On Induction Of Puberty And Fertility Response In Yearling Beef Heifers., Quinn Stephan Baptiste

Graduate Theses, Dissertations, and Problem Reports (ETD)

The effects of weight; high (HW) or low (LW), and diet; high-energy (HE) or low-energy (LE), on the fertility of 118 yearling Angus, Hereford, and Angus x Hereford beef heifers were investigated. Heifers were blocked by body weight, and randomly assigned to diets for 47 and 42 days in years, 1 and 2, respectively. Estrus was synchronized with MGA (8 d, 0.5mg/hd/d), PGF2α (25 mg i.m.), and estradiol benzoate (400 µg i.m, 48 h after PGF2α) regimen. Heifers were artificially inseminated between 78-84 h after the PGF2α injection and then exposed to a bull for the second service. Overall pregnancy …

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The Relationships Between Teacher Self-Disclosure, Student Motives, Student Affect, Relational Certainty, And Student Participation., Jacob L. Cayanus Jan 2002

The Relationships Between Teacher Self-Disclosure, Student Motives, Student Affect, Relational Certainty, And Student Participation., Jacob L. Cayanus

Graduate Theses, Dissertations, and Problem Reports (ETD)

The concept of teacher self-disclosure has been studied using a variety of methods. A review of teacher self-disclosure literature found that operationalization of teacher self disclosure had yet to be agreed upon by researchers. This thesis applied a new teacher self-disclosure scale developed primarily for this research. It was hypothesized teacher self-disclosure would be related to (1) the student motives of functional, relational, and participatory, (2) class participation, (3) affect for class, (4) affect for teacher, and (5) relational certainty. Analysis of data collected show teacher self-disclosure mildly correlated with the student motive of relational and student participation, but was …

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Factors Influencing Habitat Selection And Activity Of Ground Beetles (Coleoptera: Carabidae) In Central Appalachia. Part I. The Influence Of Soil And Soil Surface Characteristics On Habitat Selection By Carabidae. Part Ii. Precipitation And Temperature Fluctuations: Effects On Carabidae Activity. Part Iii. The Effects Of Two Microbial Insecticides For Gypsy Moth Control On Carabidae Populations., Terry R. Carrington Jan 2002

Factors Influencing Habitat Selection And Activity Of Ground Beetles (Coleoptera: Carabidae) In Central Appalachia. Part I. The Influence Of Soil And Soil Surface Characteristics On Habitat Selection By Carabidae. Part Ii. Precipitation And Temperature Fluctuations: Effects On Carabidae Activity. Part Iii. The Effects Of Two Microbial Insecticides For Gypsy Moth Control On Carabidae Populations., Terry R. Carrington

Graduate Theses, Dissertations, and Problem Reports (ETD)

A study was conducted in the George Washington National Forest in Virginia and the Monongahela National Forest in West Virginia. Carabid samples were collected over four years and compared to soil characteristics, surface characteristics and meteorological conditions to determine what role these factors play in carabid habitat selection. Opportunity also existed to compare carabid populations before and after the application of microbial insecticides on the sampling sites. This study was conducted as as part of a larger project investigating non-target impacts from gypsy moth, Lymantria dispar (L.)(Lepidoptera: Lymantriidae), insecticide applications and the interaction of Entomophaga maimaiga Humber, Shimazu, and Soper …

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The Longest Distance Between Two Points., David Lee Chance Jan 2002

The Longest Distance Between Two Points., David Lee Chance

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Longest Distance Between Two Points is a collection of short fiction and nonficiton stories written between spring semester of 2000 and spring semester of 2002 and compiled for my master's thesis. Three of the pieces were written for this collection and the other two are revisions of works composed for graduate writing workshops. The stories all deal with people who have some type of personal limitation that causes them to have trouble functioning in the world. Some of the themes that are explored in these stories are poverty, addiction, mental illness, language barriers and physical handicaps. Each story deals …

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An Evaluation Of Double-Observer Point Count Techniques And Avian Habitat Use On The Camp Dawson Collective Training Area, Preston County, West Virginia., Greg Michael Forcey Jan 2002

An Evaluation Of Double-Observer Point Count Techniques And Avian Habitat Use On The Camp Dawson Collective Training Area, Preston County, West Virginia., Greg Michael Forcey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Double-observer point counts are a new method of inventorying avian fauna that allow detection probabilities to be calculated for each point or species of bird. These detection rates allow estimation of abundances that are more robust than estimates derived from single-observer counts because detection probabilities factor in birds present but not detected. The combined double-observer (DO) technique involves two observers recording data together on a single data sheet. The primary observer dictates the number of each species that is detected while the secondary observer records this information; the secondary observer also notes birds that the primary observer did not detect. …

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The Identification Of Downstream Effectors Of The Rx Gene And Its Proposed Role In Anophthalmia/Microphthalmia., Christina Marie O'Kernick Jan 2002

The Identification Of Downstream Effectors Of The Rx Gene And Its Proposed Role In Anophthalmia/Microphthalmia., Christina Marie O'Kernick

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Retinal homeobox (Rx) gene codes for a transcriptional regulator involved in retinal tissue development, and the protein sequence of this transcription factor has been highly conserved throughout evolution. Previous Rx-knock-out and over-expression experiments have identified Rx as an essential component for proper eye formation. Here we used gene sequencing to identify 2 different mutations in the hRx gene of three anophthalmic and microphthalmic patients. The Q147X mutation, located in helix 1 of the homeodomain most likely prevents Rx from binding to DNA, therefore preventing transcriptional regulation by Rx. The R192Q mutation located in helix 3 of the homeodomain is …

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Environmental Justice Through Pollution Prevention: Development Of A Quantitative Method To Assess Community Vulnerability And Air Emission Hazard For Optimal Impact., John Lewis Boettner Iii Jan 2002

Environmental Justice Through Pollution Prevention: Development Of A Quantitative Method To Assess Community Vulnerability And Air Emission Hazard For Optimal Impact., John Lewis Boettner Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study develops a quantitative and objective method of analyzing community vulnerability combined with potential exposure to emission hazards. This extends earlier work concerning Environmental Justice Through Pollution Prevention (EJP2) initiatives for optimal selection of facilities for resource allocation for pollution prevention initiatives. A 1992 EPA report indicated that minority and low-income communities are exposed to higher levels of pollution in their neighborhoods than that of the general population. Environmental Justice is a grassroots derived term for addressing these disproportionate shares of negative environmental impacts, which are placed upon people of minority or low socio-economic status. The method developed identifies …

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