Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (347)
- Medicine and Health Sciences (147)
- Social and Behavioral Sciences (122)
- Engineering (88)
- Physical Sciences and Mathematics (82)
-
- Animal Sciences (75)
- Arts and Humanities (73)
- Neuroscience and Neurobiology (65)
- Psychology (61)
- Ecology and Evolutionary Biology (46)
- Genetics and Genomics (40)
- Medical Sciences (40)
- Biochemistry, Biophysics, and Structural Biology (38)
- Diseases (38)
- Education (38)
- Environmental Sciences (36)
- Biology (34)
- Experimental Analysis of Behavior (32)
- Microbiology (31)
- Food Science (30)
- Biochemistry (28)
- Forest Sciences (26)
- Nutrition (26)
- Cell and Developmental Biology (25)
- Molecular and Cellular Neuroscience (25)
- Immunology and Infectious Disease (23)
- Pharmacology, Toxicology and Environmental Health (23)
- Physiology (23)
- Plant Sciences (23)
- Natural Resources and Conservation (22)
- Keyword
-
- Animal sciences (97)
- Ecology (75)
- Forestry (69)
- Molecular biology (60)
- Behavioral psychology (57)
-
- Animal Physiology (56)
- Aquatic sciences (54)
- Physiology (52)
- Nutrition (50)
- Pharmacology (49)
- Microbiology (48)
- Mechanical engineering (47)
- Neurosciences (43)
- Agricultural education (42)
- Experimental psychology (37)
- Cellular biology (35)
- Environmental science (34)
- Genetics (34)
- Electrical engineering (32)
- Environmental engineering (31)
- Toxicology (31)
- Clinical psychology (29)
- Biochemistry (27)
- Wildlife management (24)
- Computer science (23)
- Soil sciences (23)
- Immunology (22)
- Biomedical engineering (21)
- Natural resource management (20)
- Veterinary science (20)
- Publication Year
- File Type
Articles 1621 - 1650 of 2809
Full-Text Articles in Entire DC Network
Mitochondrial Dysfunction In The Diabetic Heart: Cardioprotection From A Novel Mitochondrially-Targeted Therapeutic, Erinne Rose Dabkowski
Mitochondrial Dysfunction In The Diabetic Heart: Cardioprotection From A Novel Mitochondrially-Targeted Therapeutic, Erinne Rose Dabkowski
Graduate Theses, Dissertations, and Problem Reports (ETD)
Cardiovascular complications leading to heart failure are the leading cause of death amongst both type 1 and type 2 diabetic patients. Increased reactive oxygen species (ROS) generation due to hyperglycemia and an enhanced fatty acid environment has been suggested to lead to mitochondrial dysfunction. Mitochondria are particularly susceptible to oxidative damage because the inner mitochondrial membrane (IMM) is the main site of ROS generation. Mitochondrial dysfunction is complicated by the fact that two spatially-distinct subpopulations of mitochondria reside in the heart. The subsarcolemmal mitochondria (SSM) are located at the cell periphery, while the interfibrillar mitochondria (IFM) situate along the myofibrils. …
Escape From Stimuli Correlated With Transitions Across Lean And Rich Schedules Of Reinforcement, August F. Holtyn
Escape From Stimuli Correlated With Transitions Across Lean And Rich Schedules Of Reinforcement, August F. Holtyn
Graduate Theses, Dissertations, and Problem Reports (ETD)
On a multiple-schedule of reinforcement, when a rich component is followed by a relatively lean component, responding is interrupted by extended pausing. The present experiment examined whether the discriminative stimulus correlated with this rich to lean transition acquired aversive properties. Four pigeons were exposed to a compound schedule with two fixed-ratio components programmed on the center key. One component ended with the delivery of a rich reinforcer (7-s access to grain) and the second with a lean reinforcer (1-s access). Each component was correlated with a distinctive key color. At the beginning of some components, a side key was activated. …
The Effects Of Riparian Tree Harvest Intensity And Woody Debris Addition On Biotic And Abiotic Stream Characteristics, Jered Michael Studinski
The Effects Of Riparian Tree Harvest Intensity And Woody Debris Addition On Biotic And Abiotic Stream Characteristics, Jered Michael Studinski
Graduate Theses, Dissertations, and Problem Reports (ETD)
Forested headwater streams rely on riparian zones for many critical products and services. Riparian areas shade streams, stabilize stream banks, filter sediment, and provide allochthonous materials like leaves, large woody debris (LWD), and terrestrial invertebrates (TI's). Logging can affect the products and services of riparian zones. Best management practices (BMP's) have been developed to minimize the impacts of riparian timber harvest on streams. The main component of these guidelines is the establishment of a road-free riparian buffer called a streamside management zone (SMZ). The West Virginia Division of Forestry's BMP's require a SMZ that is at least 30 m wide …
Determination Of Equilibrium Binding Constants For Lps Interaction With Tlr4, Santhoshi P. Dixit
Determination Of Equilibrium Binding Constants For Lps Interaction With Tlr4, Santhoshi P. Dixit
Graduate Theses, Dissertations, and Problem Reports (ETD)
Toll-like receptors (TLRs) are the best characterized Pathogen Recognition Receptors (PRRs) and are directly responsible for initiating an appropriate defense against bacterial and viral infection. Among all the TLRs known, only TLR4 is able to activate both MyD88-dependent induction of genes encoding inflammatory molecules and TRIF-dependent production of type I interferon. Therefore, in this study we report the binding of TLR4 by Lipopolysaccharide (LPS) which is the component on the cell-wall of gram-negative bacteria. Binding of LPS is a prerequisite for the activation of Toll-like receptor 4 (TLR4) by LPS which increases the expression of critical proinflammatory cytokines that organize …
Colonial Sugar Production In Nyanza: (Kibos-Muhoroni) The Asian Initiative, The Genesis, And Development Of Kenya's Sugar Industry, 1903--1963, Godriver A. N. Wanga Odhiambo
Colonial Sugar Production In Nyanza: (Kibos-Muhoroni) The Asian Initiative, The Genesis, And Development Of Kenya's Sugar Industry, 1903--1963, Godriver A. N. Wanga Odhiambo
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study analyses Asian sugar production in colonial Nyanza examines the Asian initiative and the development of commercial cane farming in Central Nyanza. Therefore, the work provides a different perspective on Asian initiative in agriculture and provides a framework on which to understand the persistent state of insufficiency in Kenya's sugar industry.;The study mainly relied on primary sources, secondary sources and oral interviews. These sources were derived from the Kenya National Archives, Nairobi, Syracuse University's Bird Library, Ohio University Library, Moi University Library Eldoret and West Virginia University Library. The primary materials included annual reports of the Department of Agriculture, …
One-Room Schools And Their Role In The Development Of The Appalachian Hills Of West Virginia: 1863--1940s, James Seth Caudill
One-Room Schools And Their Role In The Development Of The Appalachian Hills Of West Virginia: 1863--1940s, James Seth Caudill
Graduate Theses, Dissertations, and Problem Reports (ETD)
One-room schools provided the educational settings for the majority of West Virginians until well into the twentieth century. The distribution of the population throughout the rural, rolling, and mountainous terrain resulted in the location of schools within walking distance for most students. The school population consisted of students of various ages and different grades contained in one room. Teachers required diverse skills, in order to perform as academic instructor, nurse, custodian, and entertainment leader at recess. The rural schools gave students in these communities an opportunity to achieve an education, offering both academics and life lessons. The thesis will examine …
Relationships Of Developmental Traits In Young Alpaca Crias And Lambs, Sara Elizabeth Lewis
Relationships Of Developmental Traits In Young Alpaca Crias And Lambs, Sara Elizabeth Lewis
Graduate Theses, Dissertations, and Problem Reports (ETD)
Successful reproduction in alpacas is highly dependent upon postnatal survival, which in turn is dependent upon a pattern of continuous gain in weight as an indicator of health. Weighing alpacas is the primary method used to assess their general health. Unfortunately, the measurement of cria weight is not always a simple, routine, or easy determination. The purpose of this study was to determine if, as in other species such as cattle and horses, morphometric body measurements can be used to estimate weight. In this study, continuous weight and girth measurements were taken on 34 alpaca cria. Age and girth were …
Phosphorus Nutrition In Broilers, Staci Ann Loop
Phosphorus Nutrition In Broilers, Staci Ann Loop
Graduate Theses, Dissertations, and Problem Reports (ETD)
Due to depleting resources, high feed ingredient costs, and eutrophication, phosphorus nutrition in broilers has been a topic of concern for many years. The amount of damage being done to the environment by phosphorus runoff in some states has led to regulations that require broiler litter to have decreased phosphorous with the use of a phytase enzyme. There are many phytase products on the market, however, these enzymes are not all equally effective. Companies may rely only on feed manufacture retention data instead of conducting live bird performance research to test the actual efficacy of the enzyme. The first study …
A Reconfigurable Distributed Multiagent System Optimized For Scalability, Summiya Moheuddin
A Reconfigurable Distributed Multiagent System Optimized For Scalability, Summiya Moheuddin
Graduate Theses, Dissertations, and Problem Reports (ETD)
This thesis proposes a novel solution for optimizing the size and communication overhead of a distributed multiagent system without compromising the performance. The proposed approach addresses the challenges of scalability especially when the multiagent system is large. A modified spectral clustering technique is used to partition a large network into logically related clusters. Agents are assigned to monitor dedicated clusters rather than monitor each device or node. The proposed scalable multiagent system is implemented using JADE (Java Agent Development Environment) for a large power system. The performance of the proposed topology-independent decentralized multiagent system and the scalable multiagent system is …
Elucidating The Role Of Ascorbic Acid In Flowering And Pathogen Defense In Arabidopsis Thaliana, Madhumati Mukherjee
Elucidating The Role Of Ascorbic Acid In Flowering And Pathogen Defense In Arabidopsis Thaliana, Madhumati Mukherjee
Graduate Theses, Dissertations, and Problem Reports (ETD)
L-ascorbic acid (AA) protects plants against abiotic stress. Previous studies suggested that this antioxidant is also involved in the control of flowering and enhanced disease resistance. This study aimed to elucidate the mechanisms through which AA deficiency promotes flowering and pathogen resistance.;To decipher how AA influences flowering time, four AA-deficient Arabidopsis thaliana mutants vtc1-1, vtc2-1, vtc3-1 and vtc4-1 were grown under short and long days, respectively. These mutants flowered and senesced before the wild type irrespective of the photoperiod, a response that cannot simply be attributed to slightly elevated oxidative stress in the mutants. Genetic analyses demonstrated that various photoperiodic …
Determining Efficacy Of A Thermally Processed Exogenous Enzyme Cocktail For Broilers, Kala Renea Beaman
Determining Efficacy Of A Thermally Processed Exogenous Enzyme Cocktail For Broilers, Kala Renea Beaman
Graduate Theses, Dissertations, and Problem Reports (ETD)
Feed ingredient price has influenced nutritionists to maximize diet nutrient availability through use of exogenous enzymes. Poultry are almost exclusively fed pelleted diets that entails feed being subjected to conditions of high moisture, temperature and pressure that could partially denature added enzymes. Exogenous enzyme efficacy may be decreased or completely lost if enzymes are not able to survive the pelleting process. The objective of the current studies was to properly assess the efficacy of a commercially available exogenous enzyme cocktail subjected to increasing steam conditioning temperatures during pelleting (82, 88, 93°C). Dietary treatments consisted of nutritionally adequate diets or Positive …
Dietary Cholesterol Effects On Learning, Memory And Amyloid Beta: Learning And Memory Effects On Brain Cholesterol And Sulfatide Levels, Deya S. Darwish
Dietary Cholesterol Effects On Learning, Memory And Amyloid Beta: Learning And Memory Effects On Brain Cholesterol And Sulfatide Levels, Deya S. Darwish
Graduate Theses, Dissertations, and Problem Reports (ETD)
Recent studies have revealed ambiguous findings on the effects of dietary cholesterol on learning. In one study by Schreurs and coworkers it was reported that a 2% cholesterol diet had a positive effect on learning. However, it was realized that metals, specifically copper, could potentially exacerbate the aggregation of amyloid beta (Abeta), a protein associated with Alzheimer's disease (AD) leading to the formation of Abeta plaques. In a subsequent publication by Sparks and Schreurs it was reported that a 2% cholesterol diet with the addition of 0.12 ppm copper had a detrimental effect on learning and resulted in the formation …
Text, Graphics, And Multimedia Materials Employed In Learning A Computer-Based Procedural Task, Kari Christine Carlson Coffindaffer
Text, Graphics, And Multimedia Materials Employed In Learning A Computer-Based Procedural Task, Kari Christine Carlson Coffindaffer
Graduate Theses, Dissertations, and Problem Reports (ETD)
The present research study investigated the interaction of graphic design students with different forms of software training materials. Four versions of the procedural task instructions were developed (A) Traditional Textbook with Still Images, (B) Modified Text with Integrated Still Images, (C) Onscreen Modified Text with Silent Onscreen Video and (D) Onscreen Narrated Video for four computer tasks. Two research questions guided the study: Research Question 1: Are there any significant differences in student learning of a computer-based procedural task due to the format of the training materials? Research Question 2: Do individual differences in prior knowledge and spatial abilities make …
Changes In Throwing Pattern And Perceptual Judgment As The Function Of Task Variations For Young Children, Yoojin Choi
Changes In Throwing Pattern And Perceptual Judgment As The Function Of Task Variations For Young Children, Yoojin Choi
Graduate Theses, Dissertations, and Problem Reports (ETD)
Ecological Task Analysis (ETA; Davis & Burton, 1991) hypothesizes that movement change may emerge from dynamic interaction in given environmental conditions. In other words, task variability provides opportunities for the performer to choose skills suitable to his or her capabilities in order to achieve a task goal.;The purpose of the present study is to examine 4 year-old children's changes in throwing patterns and perceptual judgment as a function of task variation in specific throwing tasks. Each experiment identifies various task parameters (e.g., force, trajectory of throws) and attempts to adjust them to meet a task goal.;The modifications of tasks include …
The Ku Klux Klan's Portrayal Of African Americans In Mass Media Technology, Heather R. Sager
The Ku Klux Klan's Portrayal Of African Americans In Mass Media Technology, Heather R. Sager
Graduate Theses, Dissertations, and Problem Reports (ETD)
The White supremacy group, the Ku Klux Klan was formed in 1866, after the end of the Civil War, in the small town of Pulaski, TN, by six ex-Confederate soldiers. Over the last 143 years the Klan has tried to take full advantage of the media in order to reach the largest audience possible to make its voice heard and spread its ideologies of hate towards African Americans and other minority groups. This study focuses on the similarities and differences in the Klan's portrayal of African Americans between two great technological advances used by the Klan---motion pictures from the twentieth …
Effect Of Conjugated Linoleic Acid On The Regulation Of Feed Intake And Body Fat In The Short Term, Valerie J. Shelton
Effect Of Conjugated Linoleic Acid On The Regulation Of Feed Intake And Body Fat In The Short Term, Valerie J. Shelton
Graduate Theses, Dissertations, and Problem Reports (ETD)
Conjugated linoleic acid (CLA) is known to decrease feed intake and body fat in mice. Our objectives were to determine the incorporation of CLA into tissues and the effect on serum hormones and arcuate neuropeptides during the first 7 d of CLA consumption. Mice (n=150; 9-wk-old) were fed 0 (ad libitum or pair-fed to CLA-fed mice) or 2% CLA (ad libitum) for 1, 2, 3, 5, or 7 d. A body fat index was calculated; liver, adipose tissue, and brain were analyzed for fatty acid profiles; and serum insulin, leptin, and PYY were measured. CLA and pair-fed mice ate less …
Effect Of Nutritional Deficiency On Ruffed Grouse Condition And Reproductive Success, Aaron B. Proctor
Effect Of Nutritional Deficiency On Ruffed Grouse Condition And Reproductive Success, Aaron B. Proctor
Graduate Theses, Dissertations, and Problem Reports (ETD)
Maternal body fat condition (i.e., percent carcass fat) is often a focal point in determining reproductive success in female galliforms. Previous research has centered around habitat-related nutritional parameters affecting body condition and the influence on reproductive capacity. Past studies have shown that ruffed grouse (Bonasa umbellus) maintain higher mean body fat levels throughout the Appalachians and variation in body condition exceeds that found in northern grouse. In the Appalachians, ruffed grouse with diets devoid of energy-rich hard mast have lower body fat condition. It has been hypothesized that females in poorer condition will have lower productivity in the Appalachians. We …
Justifying Phytogenic Feed Additive Matrix Values In Conjunction With Exogenous Feed Enzymes, Laurel K. Shires
Justifying Phytogenic Feed Additive Matrix Values In Conjunction With Exogenous Feed Enzymes, Laurel K. Shires
Graduate Theses, Dissertations, and Problem Reports (ETD)
Phytogenic feed additives are purported to possess antimicrobial properties as well as nutrient sparing characteristics that may aid in alleviating high diet costs; however, in order for PFAs to assist nutritionists in decreasing diet cost, matrix values must be determined and implemented in feed formulation. Study 1 evaluated proposed matrix values for a commercially available PFA and assessed nutrient sparing when the product was combined with commercial phytase, carbohydrase and protease. The most remarkable proposed matrix values were 32.2 kcal/kg for metabolizable energy and 0.07% for both Ca and AP. The objective of Study 2 was to determine true amino …
Systemic Lipopolysaccharide Stimulates Airway Transepithelial Na+ Transport By Increasing Enac And Na+,K+ -Pump Activity, Michael W. Dodrill
Systemic Lipopolysaccharide Stimulates Airway Transepithelial Na+ Transport By Increasing Enac And Na+,K+ -Pump Activity, Michael W. Dodrill
Graduate Theses, Dissertations, and Problem Reports (ETD)
Our laboratory found that systemic administration of lipopolysaccharide (LPS; 4 mg/kg) hyperpolarized the transepithelial potential difference (V t) of tracheal epithelium in the isolated, perfused trachea (IPT) of the guinea pig 18 h after injection. We hypothesized that LPS stimulates the transepithelial movement of Na+ via the epithelial sodium channel (ENaC)/Na+,K+-pump axis, leading to hyperpolarization of Vt. LPS increased the Vt response to amiloride, i.e., offset the effect of LPS, indicating that Na+ transport was increased. The functional activity of ENaC was measured in the IPT after short-circuiting the Na+,K+-pump with basolateral amphotericin B. LPS had no effect on the …
Hypercholesterolemia And Microvascular Dysfunction: Altered Mechanisms And Interventional Strategies, Phoebe Stapleton
Hypercholesterolemia And Microvascular Dysfunction: Altered Mechanisms And Interventional Strategies, Phoebe Stapleton
Graduate Theses, Dissertations, and Problem Reports (ETD)
Cardiovascular disease has a number of risk factors and confounding variables associated with the development and progression of the condition. Hypercholesterolemia is one of the few independent risk factors of peripheral vascular disease (PVD) and coronary artery disease (CAD) with causes stemming from a genetic predisposition and lifestyle management. The primary symptom of these diseases can be described as an endothelial cell dysfunction, which hypercholesterolemia can exacerbate, leading to a pro-inflammatory state of elevated oxidant stress and significant reduction in nitric oxide (NO) bioavailability, a key mediator of endothelium-dependent dilation. This environment can culminate into an impairment of the vascular …
A Component Based Model For The Prediction Of The Product Yields Of The Pyrolysis Of A Biomass Particle, Brian C. Eberly
A Component Based Model For The Prediction Of The Product Yields Of The Pyrolysis Of A Biomass Particle, Brian C. Eberly
Graduate Theses, Dissertations, and Problem Reports (ETD)
Pyrolysis of biomass can produce several useful, renewable products: biochar for soil amendment and long-term carbon sequestration; tars for chemicals and biofuels; and syngas as an energy and biofuel production feedstock. The ability to predict the relative yields of gas, tar and char from the pyrolysis process of various biomasses will enable optimization of pyrolysis process for specific yield ratios. Component based kinetic and 1-D pyrolysis models are developed wherein the woody biomass is characterized by the mass percentage of its three primary components: cellulose, hemicellulose and lignin. Using dual stage mechanisms for primary component pyrolysis and tar cracking reactions, …
Playback Surveys And Breeding Habitat Characteristics Of Golden-Winged Warblers (Vermivora Chrysoptera) On High-Elevation Pasturelands On The Monongahela National Forest, West Virginia, Kyle Ray Aldinger
Graduate Theses, Dissertations, and Problem Reports (ETD)
Across the breeding range of the Golden-winged Warbler (Vermivora chrysoptera), significant population declines have been documented even before the implementation of the North American Breeding Bird Survey (BBS) and continue as such today. The plight of this species has been blamed on the loss and degradation of early successional habitat, interactions with the closely related Blue-winged Warbler (Vermivora pinus), and Brown-headed Cowbird (Molothrus ater) brood parasitism. Most breeding Golden-winged Warblers are found in the upper Midwest and Great Lakes regions of the United States, but there are considerable populations persisting at higher elevations (>600 m) in the central Appalachian …
Effects Of Level Of Concentrate Supplementation On Milk Production And Ruminal Ph In Lactating Cows On Pasture, Gatha R. Clevenger
Effects Of Level Of Concentrate Supplementation On Milk Production And Ruminal Ph In Lactating Cows On Pasture, Gatha R. Clevenger
Graduate Theses, Dissertations, and Problem Reports (ETD)
The effects of concentrate supplementation on milk production and ruminal fermentation was evaluated in six ruminally cannulated lactating Holstein dairy cows in a Latin rectangle design. Cows were fed 4 (C4), 8 (C8), and 12 (C12) kg DM/d of a concentrate supplement. Increasing amounts of concentrate supplement decreased pasture intake, but increased overall dry matter intake (DMI) and increased milk production without changing milk composition. Daily mean and minimum ruminal pH was similar for all treatments. Increasing supplementation increased time spent below pH 5.8, and resulted in a reduction in the in situ degradability of DM and NDF at 24 …
Veterinary Anatomy Laboratory Impact Study, Bess Catherine Hammill
Veterinary Anatomy Laboratory Impact Study, Bess Catherine Hammill
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study examines the scholastic impact and opinion of learning in the anatomy laboratory as it relates to the lecture. The teaching of Animal Anatomy in the Animal Science department has traditionally been taught via classroom lecture and supported with a textbook. This study compares one scholastic semester without a laboratory and another scholastic semester offering a laboratory in partnership with the traditional lecture. The students without a laboratory were examined by means of their final grades in comparison with the laboratory and lecture combination. In order to acquire perspectives on the impact the laboratory had on student learning a …
Sex Differences In The Myocardial Response To Prenatal And Behavioral Stress, Heather Rose Mullenax
Sex Differences In The Myocardial Response To Prenatal And Behavioral Stress, Heather Rose Mullenax
Graduate Theses, Dissertations, and Problem Reports (ETD)
Prenatal stress (PS) has been shown to exert profound effects on many organs in a variety of species. There is considerable evidence for sex-specific effects of prenatal stress. Our laboratory is the first to report effects of prenatal stress on myocardial function in male rats. The purpose of this study was to confirm our previous evidence of differences in myocardial function among prenatally stressed male and female rats and to explore possible mechanisms responsible for this difference. In this study, male and female Sprague-Dawley rats were subjected to prenatal stress (mother was stressed on day 14--21 of gestation) followed by …
The Stability Of The Wala Ridge As A Landmark For Determining Dental Arch Form, Kolin E. Weaver
The Stability Of The Wala Ridge As A Landmark For Determining Dental Arch Form, Kolin E. Weaver
Graduate Theses, Dissertations, and Problem Reports (ETD)
Objectives. To evaluate changes to the WALA Ridge when subjected to orthodontic treatment using customized WALA Ridge archwires and preformed archwires, and ascertain trends within the United States amongst practicing orthodontists regarding arch form selection. Methods. 10 control subjects, 20 customized archwire subjects, and 20 preformed archwire subjects were compared using pre and post treatment mandibular casts for the experimental groups and two timepoint mandibular casts with two years between collection for the control group. Dental and Dentoalveolar changes were then measured from T1 to T2 for each of the groups. Furthermore, an electronic survey was distributed to all active …
The Effect Of Aging And Resveratrol Supplementation On Bone Mass And Strength In Hindlimb Suspended Male Rats, Stephanie Wright
The Effect Of Aging And Resveratrol Supplementation On Bone Mass And Strength In Hindlimb Suspended Male Rats, Stephanie Wright
Graduate Theses, Dissertations, and Problem Reports (ETD)
Resveratrol has recently become a popular dietary supplement because of its potential for reducing the effects of aging and various age-related diseases. However, few studies have investigated the role of resveratrol in improving bone loss associated with aging. It has been widely reported that mechanical unloading increases bone loss. The elderly experience a prevalence of reduced mechanical loading due to declining activity levels and increased incidence of bed rest. In rats, hind-limb suspension (HLS) simulates mechanical unloading of bone. Therefore, the objective of this study was to examine the effects of aging and resveratrol supplementation on bone health in HLS …
Alterations In T Cell Function And Activation During Exposure To The Herbicide 3,4 Dichloropropionanilide (Dcpa) And Its Metabolites, Tricia L. Lewis
Alterations In T Cell Function And Activation During Exposure To The Herbicide 3,4 Dichloropropionanilide (Dcpa) And Its Metabolites, Tricia L. Lewis
Graduate Theses, Dissertations, and Problem Reports (ETD)
Approximately 5.3 billion pounds of pesticides are applied annually across the United States and 15 of the top 25 most used pesticides are herbicides. Total herbicide use the in the United States represents 28% of all worldwide herbicide use. DCPA (3,4 dichloropropionanilide, common name propanil) is a post emergent herbicide that is used extensively for control against several broadleaf plants and grasses. It is the 17th most common herbicide in the United States and 6--9 million pounds are applied annually to 2 million acres of rice fields. In mammals, DCPA is metabolized in the liver and produces 3,4-dichloroaniline (DCA) and …
Cytochrome P450 1a-Ligand Interactions: Implications For Substrate Specificity And Inhibitor Susceptibility, Qingbiao Huang
Cytochrome P450 1a-Ligand Interactions: Implications For Substrate Specificity And Inhibitor Susceptibility, Qingbiao Huang
Graduate Theses, Dissertations, and Problem Reports (ETD)
Cytochromes P450 are heme-containing enzymes that are involved in the metabolism of a variety of clinically important drugs, endogenous and exogenous compounds, including a number of procarcinogens. P450 1A subfamily has two members: 1A1 and 1A2. P450 1A1 and 1A2 show high sequence identity (>70%), but display different substrate specificity and inhibitor susceptibility. P450 1A2 is one of the major hepatic P450s, which metabolizes more than 11% of drugs currently on the market. Thus, we focused our attention on studies of this particular P450.;The five key active site residues that are different between P450 1A1 and 1A2 have been …
Ve-Cadherin Expression And Regulation Of Sensitivity To Apoptosis In Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia, Heather A. O'Leary
Ve-Cadherin Expression And Regulation Of Sensitivity To Apoptosis In Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia, Heather A. O'Leary
Graduate Theses, Dissertations, and Problem Reports (ETD)
The bone marrow microenvironment serves as the primary site for post-natal hematopoiesis allowing for HSC development and maturation. More specifically, B lineage cells rely on key signals from both the physical and soluble components of the marrow for their survival and maturation. In addition to normal hematopoiesis the bone marrow has been shown to be a sanctuary for leukemic cells, as well as other tumors, that can interact with cues from the microenvironment allowing for their protection during chemotherapy. The studies described in this dissertation focus on two supportive components of the bone marrow microenvironment, osteoblasts and bone marrow stromal …