Digital Commons Network^™

Prostate-Specific Antigen Testing Patterns And Prostate Cancer Stage At Diagnosis In Older Ohio Cancer Patients, Sajan N. Patel, Long Vu, Holly E. Hartman, Weichuan Dong, Siran M. Koroukian, Johnie Rose

Faculty Scholarship

Background: Prostate cancer (PCa) screening recommendations do not support prostate-specific antigen (PSA) screening for older men. Such screening often occurs, however. It is, therefore, important to understand how frequently and among which subgroups screening occurs, and the extent of distant stage PCa diagnoses among screened older men. Methods: Using the 2014–2016 linked Ohio Cancer Incidence Surveillance System (OCISS) and Medicare administrative database, we identified men 68 and older diagnosed with PCa and categorized their PSA testing in the three years preceding diagnosis as screening or diagnostic. We conducted multivariable logistic regression analysis to identify correlates of screening PSA and to …

Physiological Role For S-Nitrosylation Of Ryr1 In Skeletal Muscle Function And Development, Qi-An Sun, Zachary W. Grimmett, Douglas T. Hess, Zhaoxia Qian, Ruchi Chaube, Nicholas M. Venetos, Bradley N. Plummer, Kenneth R. Laurita, Richard T. Premont, Jonathan S. Stamler

Faculty Scholarship

Excitation-contraction coupling in skeletal muscle myofibers depends upon Ca2+ release from the sarcoplasmic reticulum through the ryanodine receptor/Ca2+-release channel RyR1. The RyR1 contains ∼100 Cys thiols of which ∼30 comprise an allosteric network subject to posttranslational modification by S-nitrosylation, S-palmitoylation and S-oxidation. However, the role and function of these modifications is not understood. Although aberrant S-nitrosylation of multiple unidentified sites has been associated with dystrophic diseases, malignant hyperthermia and other myopathic syndromes, S-nitrosylation in physiological situations is reportedly specific to a single (1 of ∼100) Cys in RyR1, Cys3636 in a manner gated by pO2. Using mice expressing a form …

Neurovascular Shifts, Sensory Sensitivity, And Pmdd In Autistic Women: Exploring Blood Flow Redirection, Mood Dysregulation, And Pain Tolerance During Menstruation, Piper Hutson, James Hutson

Faculty Scholarship

This article examines the relationship between Premenstrual Dysphoric Disorder (PMDD), neurovascular dynamics, and sensory sensitivities in autistic women during menstruation. The redirection of blood flow to the uterus during the menstrual cycle has been found to exacerbate cerebral perfusion deficits in neurodivergent individuals, particularly in the Prefrontal Cortex (PFC), which contributes to the mood dysregulation and emotional instability characteristic of PMDD. Autistic women, who often exhibit heightened sensory sensitivities, experience intensified discomfort during menstruation, as sensory overload and altered pain perception compound the emotional challenges of PMDD. These findings emphasize the need for neurodivergent-friendly menstrual products that mitigate both physical …

Navigating Life: Neuroscience And Inclusive Design In Wayfinding Systems, Stephanie Jost, Piper Hutson, James Hutson

Faculty Scholarship

Wayfinding, as conceptualized by Lynch, has transformed from traditional navigation methods reliant on visual cues and landmarks to modern systems that integrate digital technologies and neuroscience. This study addresses the need for accessible and consistent wayfinding systems that accommodate diverse user abilities, particularly in complex environments such as public transit, hospitals, and large institutions. Current systems often lack coordination, clear signage, and comprehensive coverage, leading to navigation challenges. Through a multi-method approach, including literature review and case study analysis, this research evaluates best practices for inclusive wayfinding. Key findings emphasize the importance of consistent visual design, strategic sign placement, and …

Impact Of Resin Molecular Weight On Drying Kinetics And Sag Of Coatings, Marola W. Issa, Christpher L. Wirth

Faculty Scholarship

Coating performance is influenced by factors inherent to formulation design and processing conditions. Understanding the complex interplay of these attributes enables for mitigating defects, such as sag, which is a gravity-driven phenomenon that impacts the aesthetic and functionality of a coating. The work herein investigates the impact of resin molecular weight and solvent choice on the drying kinetics and sag velocity in polymer films. These films, ranging in thickness from ~60 μm to ~120 μm were formulated with 45 % by weight polymer resin in one of two solvent packages with different relative evaporation rates (RER). Gravimetry was initially used …

Satirical Deepfakes, Surreal Dreamscapes & Nostalgic Pixels: The Rapid Evolution And Cultural Commentary Of Ai-Aesthetics, Andrew Smith, James Hutson

Faculty Scholarship

The rapid evolution of visual aesthetics driven by AI, shared globally through the internet and social media, has dramatically accelerated what once took centuries to develop. This article explores the unique visual tropes emerging from AI-generated content, characterized by surreal, uncanny, and often unsettling imagery. Examples range from the Dor Brothers' stylized narrative videos to horrifying depictions of transformations, such as people morphing into motorcycles. The article contextualizes this aesthetic within historical developments in creative experimentation, drawing parallels with David Bowie's unconventional approach to sound creation in the 1970s. It also considers how AI-driven art, free from copyright constraints in …

Ai Satire And Digital Dystopia: The Dor Brothers Crafting Imperfection And Political Commentary In Contemporary Video Art, James Hutson, Andrew Smith

Faculty Scholarship

The Dor Brothers' AI-generated video content exemplifies an inflection point in digital creativity, where technological limitations are repurposed as aesthetic tools. Drawing on recent interviews with Yonatan Dor, this article explores the innovative techniques of the brothers, such as masking visual imperfections with retro filters and embracing the unpredictability of AI outputs. Through generating numerous clips and meticulously editing selections, they create a unique aesthetic that juxtaposes surrealism with a gritty realism, often reminiscent of early CCTV or VHS footage. Their work not only transcends the typical "morphing face" trope of AI videos but also engages in satire, using deepfake-like …

Contemplating Existence: Ai And The Meaning Of Life, Emily Barnes, James Hutson

Faculty Scholarship

This article explores the intersection of artificial intelligence (AI) with existential philosophy, examining how AI technologies influence human conceptualizations of purpose and meaning. Despite rapid advancements in AI, the domain's implications for existential thought remain underexplored. By integrating interdisciplinary perspectives from psychology, philosophy, and AI ethics, this study elucidates how AI can shape, challenge, or enhance our understanding of life's purpose. It investigates theoretical frameworks and practical implementations of AI engaging in existential questions, analyzing both the capabilities and limitations of AI systems such as ChatGPT in simulating human existential thought. The ethical implications of AI's role in existential inquiries …

New York Falling Behind In Implementing Bold Climate Law, Michael B. Gerrard

Faculty Scholarship

In July 2019, shortly after Gov. Andrew Cuomo signed the Climate Leadership and Community Protection Act (CLCPA), I wrote in an op-ed, “The champagne corks are still popping. But the realization is dawning that implementing the new law will be really, really hard. New York is boldly going where no state has gone before … It will take a great deal of sweat and treasure (no one knows just how much), as well as a continuation of the political will that brought us to this point.”

We still do not know how much sweat and treasure will be required, but …

Going "Beyond" Mere Transformation: Warhol And Reconciliation Of The Derivative Work Right And Fair Use, Shyamkrishna Balganesh, Peter S. Menell

Faculty Scholarship

The Supreme Court’s recent decision in Andy Warhol Foundation for Visual Arts, Inc. v. Goldsmith is a watershed moment in the story of copyright jurisprudence. At its broadest, the decision articulates a unified vision — one that had been dormant in the lower court fair use jurisprudence — about the role of copyright and the manner in which to make sense of its effort to balance exclusivity with its myriad limitations. This Essay focuses on how the Court reconciled the working of the statute’s derivative work right with the breadth and reach of the “transformative use” version of the fair …

Enhancing History Education With Google Notebooklm: Case Study Of Mary Easton Sibley’S Diary For Multimedia Content And Podcast Creation, Paul Huffman, James Hutson

Faculty Scholarship

This article explores new features of Google’s NotebookLM, an AI-powered tool designed for advanced document analysis and educational content generation. Tested on the 92-page transcribed diary of Mary Easton Sibley, the founder of Lindenwood University, NotebookLM effectively generated FAQs, a study guide, a table of contents, a briefing document, and an audio overview in podcast format. By transforming static historical documents into dynamic learning materials, the document-based AI model provides a user-friendly interface for educators and students, especially those without experience in audio editing or podcasting. While successful in creating study guides and audio formats, the tool faced challenges in …

Inmate Assistance Programs, Tim Friehe, Murat C. Mungan

Faculty Scholarship

This paper analyzes the deterrence implications of different inmate assistance programs (IAPs), carefully distinguishing between deterrence of first offenses and recidivism. All IAPs considered in our model reduce recidivism, and we identify IAPs that also reduce the first offense rate. However, IAPs which increase work opportunities, improve the reintegration of exiting inmates, and moderate individual’s self-control issues may lower the deterrence of first offenses, if this possibility is not adequately anticipated when designing these IAPs.

Administrative Arrest Warrants: Armed Encounters Outside The Judicial Process, Meg Penrose

Faculty Scholarship

This Article considers three related questions. First, is a person “seized” under the Fourth Amendment when law enforcement restricts a person’s movements in their home and limits their ability to leave or go about their business? Second, does the answer to this seizure inquiry turn on the person’s citizenship status? And third, how do lawyers ensure that courts discard bad law? This last question is not a qualitative assessment— with good and bad law being tied to one’s legal ideology. Rather, certain legal holdings, dating back over half a century, have been whittled away if not entirely eroded. When this …

From The Bench, Pierre Leval, M. Margaret Mckeown, Jane C. Ginsburg

Faculty Scholarship

Lightly edited transcript of panel comments at the 2023 Symposium, “Rearrange, Transform, or Adapt: The Derivative Works Right After Andy Warhol Foundation v. Goldsmith.”

The Influence Of The Race Of Defendant And The Race Of Victim On Capital Charging And Sentencing In California, Catherine M. Grosso, Jeffrey A. Fagan, Michael Laurence

Faculty Scholarship

The California Racial Justice Act of 2020 recognized racial and ethnic discrimination as a basis for relief in capital cases, expressly permitting several types of statistical evidence to be introduced. This statewide study of the influence of race and ethnicity on the application of capital punishment contributes to this evidence. We draw on data from over 27,000 murder and manslaughter convictions in California state courts between 1978 and 2002. Using multiple methods, we found significant racial and ethnic disparities in charging and sentencing decisions. Controlling for defendant culpability and specific statutory aggravators, we show that Black and Latinx defendants and …

Critical Race Theory As Legal Epistemic Justice, Jasmine Gonzales Rose

Faculty Scholarship

“Critical Thinking: Not Critical Race Theory” and “Teach Truth: Not CRT,” proclaimed the front and back of a T-shirt on a fellow traveler passing in the airport. I was startled by the blatant misconceptions. The core pursuits of critical race theory (“CRT”) are to think critically, discover truth, and diversify knowledge about race and racism. Although I was aware of then-President Trump’s executive order barring federal diversity training and bills modeled after it, nothing had prepared me for the realization that my academic subfield had become so widely criticized that it was now the subject of T-shirt slogans. A few …

Is Distance From Innovation A Barrier To The Adoption Of Artificial Intelligence?, Jennifer Hunt, Iain Cockburn, James Bessen

Faculty Scholarship

Using our own data on Artificial Intelligence publications merged with Burning Glass vacancy data for 2007-2019, we investigate whether online vacancies for jobs requiring AI skills grow more slowly in U.S. locations farther from pre-2007 AI innovation hotspots. We find that a commuting zone which is an additional 200km (125 miles) from the closest AI hotspot has 17% lower growth in AI jobs’ share of vacancies. This is driven by distance from AI papers rather than AI patents. Distance reduces growth in AI research jobs as well as in jobs adapting AI to new industries, as evidenced by strong effects …

Bridging Disciplines With Ai-Powered Coding: Empowering Non-Stem Students To Build Advanced Apis In The Humanities, Daniel Plate, James Hutson

Faculty Scholarship

The integration of AI-powered coding assistants, such as Cursor AI, GitHub Copilot, and Replit’s Ghostwriter AI, represents a transformative shift in programming education, particularly for non-STEM students. These tools democratize coding by enabling natural language code generation, intelligent error correction, and context-aware assistance within familiar coding environments. This article explores how these technologies empower educators across disciplines to introduce basic and advanced coding concepts to humanities students, a demographic traditionally underserved in programming education. By leveraging AI, instructors can teach non-STEM students the foundational principles of coding and guide them through the development of sophisticated projects, such as building APIs …

Technoculture And Language Models In Archaeology: Reconstructing And Preserving Cultural Narratives Through Digital Humanities, James Hutson

Faculty Scholarship

Technoculture, which examines the intersection of culture and technology, has increasingly permeated archaeological practice, transforming both scholarly research and public engagement [1-3]. The introduction of digital tools such as virtual reality (VR), geographic information systems (GIS), and large language models (LLMs) has democratized access to archaeological knowledge, enabling communities to engage more actively with their cultural heritage [4-6]. This short article explores the mutual influence of technocultural studies and AI technologies on archaeology, with a focus on the preservation and reconstruction of cultural narratives through digital means.

The first aspect of this intersection lies in how technocultural tools are creating …

Developing Empathetic Ai: Exploring The Potential Of Artificial Intelligence To Understand And Simulate Family Dynamics And Cultural Identity, Emily Barnes, James Hutson

Faculty Scholarship

The rapid advancement of Artificial Intelligence (AI) has significantly impacted various domains. Yet, the exploration of AI's potential to develop a deep understanding of family culture and identity remains underexplored. This study introduces the concept of "a love of grandma and apple pie" to symbolize the potential of various AI to internalize and appreciate familial relationships, cultural traditions, and personal identity. The proposed study would investigate how an advanced deep learning model, trained on diverse unstructured datasets—including multimedia data from 100 families-could learn and reflect human-like emotions, values, and cultural understanding. Utilizing Convolutional Neural Networks (CNNs) for visual data processing …

What The Warhol Court Got Wrong: Use As An Artist Reference And The Derivative Work Doctrine, Jessica Silbey, Eva Subotnik

Faculty Scholarship

In Andy Warhol Foundation for the Visual Arts, Inc. v. Goldsmith, the Supreme Court conflated “use as an artist reference” with preparing a “derivative work.” It did so on the erroneous assumption that permission to use a copyrighted work as an artist reference is a license to prepare a derivative work. But copyright law does not necessarily deem all uses of references for making new art to be the preparation of a derivative work. In other words, not all adaptations of an original work are infringing. Some may be neither derivative works nor substantially similar copies, and some may …

Perpetuating Inequality: What Salary History Bans Reveal About Wages, James Bessen, Chen Meng, Erich Denk

Faculty Scholarship

Pay gaps for women and minorities have persisted after accounting for observable differences. Why? If employers can access applicants’ salary histories while bargaining over wages, they can take advantage of past inequities, perpetuating inequality. Recently, a dozen US states have banned employer access to salary histories. We analyze the effects of these salary history bans (SHBs) on employer wage posting and pay in a difference-in-differences design. Following SHBs, employers posted wages more often and increased pay for job changers, particularly for women (6.4%) and non-whites (7.7%). Bargaining behavior appears to account for much of the persistence of residual wage gaps.

Diffuse Interface Modeling Of Non-Isothermal Stokes-Darcy Flow With Immersed Transmissibility Conditions, Hyoung Suk Suh

Faculty Scholarship

The coupling between free and porous medium flows has received significant attention since it plays an important role in a wide range of problems from fluid-soil interactions to biofluid dynamics. However, modeling this coupled process remains a difficult task as it often involves a domain decomposition algorithm in conjunction with a special treatment at the interface. The problem can become more challenging under non-isothermal conditions because it requires the iterative procedure at every time step to simultaneously meet the transient mass continuity, force equilibrium, and energy balance for the entire system. This article presents a diffuse interface framework for modeling …

Carbon-Sulfur Bond Elongation As The Promoting Reaction Coordinate In The Efficient Sub-Nanosecond Intersystem Crossing In Thianaphthene Derivatives, Cameron Griffith, Erqian Mao, Sean J. Hoehn, Sarah E. Krul, Carlos E. Crespo-Hernández

Faculty Scholarship

Thiophene derivatives have become integral to OLEDs, photovoltaics, and photodynamic therapy research. A deeper understanding of their excited state dynamics and electronic relaxation mechanisms is expected to provide important physical insights of direct relevance for these applications. In this study, thianaphthene (TN), 2-methylbenzothiophene (2MBT), and 3-methylbenzothiophene (3MBT) are investigated using femtosecond broadband transient absorption and steady-state spectroscopy techniques along with time-dependent density functional calculations in cyclohexane and acetonitrile. The photophysical properties and electronic relaxation mechanisms of these derivatives are elucidated. Small fluorescence quantum yields ranging from 0.4 to 1.1% are measured. It is demonstrated that excitation of TN at 290 …

A Magnetic-Directed Micro-Particle With Near-Ir Light Triggered Guest-Release Property, Jin Ge, Xiang Cheng, Lihan Rong

Faculty Scholarship

In this study, guest carriers, composed of magnetic-directed hydrogel particles with near-infrared (NIR)-light-triggered guest-release properties, are prepared via the one-pot method. The gel particles contain photostable NIR-responsive polypyrrole nanoparticles with temperature-sensitive poly(N-isopropyl acrylamide), the combination of which can induce the accelerated release of encapsulated drugs by 337% upon 5 minutes of NIR light irradiation based on the release profile of NRMG-1 at 10–15 min. Additionally, with magnetic iron oxide particles crosslinking the polyvinyl alcohol frames, these gel particles can form a physical barrier that decreases the release rate by 20% under an external magnetic field over 24 h. The magnetic …

3d Mr Fingerprinting For Dynamic Contrast-Enhanced Imaging Of Whole Mouse Brain, Yuran Zhu, Yuning Gu, Walter Zhao, Jiahao Lu, Junqing Zhu, Christina J. Macaskill, Andrew Dupuis, Mark A. Griswold, Dan Ma, Chris A. Flask, Xin Yu

Faculty Scholarship

Purpose: Quantitative MRI enables direct quantification of contrast agent concentrations in contrast-enhanced scans. However, the lengthy scan times required by conventional methods are inadequate for tracking contrast agent transport dynamically in mouse brain. We developed a 3D MR fingerprinting (MRF) method for simultaneous T1 and T2 mapping across the whole mouse brain with 4.3-min temporal resolution. Method: We designed a 3D MRF sequence with variable acquisition segment lengths and magnetization preparations on a 9.4T preclinical MRI scanner. Model-based reconstruction approaches were employed to improve the accuracy and speed of MRF acquisition. The method's accuracy for T1 and T2 measurements was …

Living Collections: Biodiversity Cultivated At Public Gardens Has The Power To Connect Ecological Questions And Evolutionary Context, Jean H. Burns, Katharine L. Stuble, Juliana S. Medeiros

Faculty Scholarship

Combining ecological questions with evolutionary context generates novel insight into both ecology and evolution. However, our ability to draw broad inferences can be limited by the taxonomic diversity present within and across species at a site. Public gardens (including botanical gardens and arboreta) may focus solely on aesthetics in developing their gardens, but some public gardens include scientific inquiry and conservation at the core of their missions (Hohn, 2022). These scientifically oriented public gardens follow community standards of excellence (Hohn, 2022) to provide unique access to curated plant collections specifically designed to gather high levels of biodiversity, both among and …

Development Of A Selective Novel Fluorescent Substrate For Sodium-Dependent Transporters, Richard S. Agnes, Raymond F. Muzic Jr.

Faculty Scholarship

Aim: To synthesize, characterize, and validate 6FGA, a fluorescent glucose modified with a Cyanine5.5 at carbon-6 position, for probing the function of sodium-dependent glucose transporters, SGLT1 and SGLT2. Main methods: The synthesis of fluorescent glucose analogue was achieved through “click chemistry” of Cyanine5.5-alkyne and 6-azido-6-deoxy-D-glucose. Cell system studies were conducted to characterize the in vivo transport properties. Key findings: Optical analyses revealed that 6FGA displayed similar spectral profiles to Cyanine5.5 in DMSO, allowing for concentration determination, thus supporting its utility in quantitative kinetic studies within biological assays. Uptake studies in cell system SGLT models, LLC-PK1 and HEK293 cells, exhibited concentration …

Scheduling Meetings: Are The Odds In Your Favor?, Harsh Mathur

Faculty Scholarship

Abstract: Polling all the participants to find a time when everyone is available is the ubiquitous method of scheduling meetings nowadays. We examine the probability of a poll with m participants and ℓ possible meeting times succeeding, where each participant rejects r of the ℓ options. For large ℓ and fixed r/ℓ, we can carry out a saddle-point expansion and obtain analytical results for the probability of success. Despite the thermodynamic limit of large ℓ, the ‘microcanonical’ version of the problem where each participant rejects exactly r possible meeting times, and the ‘canonical’ version where each participant has a probability …

Association Between Residential Distance To Airport And Blood Lead Levels In Children Under 6 Living In North Carolina, 1992–2015, Abdul-Nasah Soale

Faculty Scholarship

Even with progress in lead poisoning prevention, research has consistently shown there is no safe blood lead level (BLL) for children.1 Behavioral and cognitive deficits are associated with lead exposure, even at low levels.2 Unfortunately, many piston-engine aircraft are still fueled by leaded aviation gas (avgas). The US Environmental Protection Agency (EPA) estimates that 5.2 million people live within 500m of an airport where avgas is used.3 Our past research in six North Carolina (NC) counties indicates that children living within 500m of airports where avgas is used have ∼4% higher BLLs than children who lived beyond 2,000m (reference group); …