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Articles 661 - 690 of 12210
Full-Text Articles in Entire DC Network
The Demise Of Deference — And The Rise Of Delegation To Interpret?, Thomas W. Merrill
The Demise Of Deference — And The Rise Of Delegation To Interpret?, Thomas W. Merrill
Faculty Scholarship
In the concluding days of its recently completed Term, in the midst of headline-grabbing decisions about presidential immunity, gun rights, and abortion, the Supreme Court rendered a momentous decision overruling the Chevron doctrine. The decision in Loper Bright Enterprises v. Raimondo was not a surprise. After treating the Chevron doctrine as a settled principle of administrative law for more than three decades, the Court stopped applying it in 2016. Several Justices authored individual opinions urging that it was unconstitutional, violated the Administrative Procedure Act (APA), was prone to manipulation by judges, created systematic bias in favor of the government, and …
The Role Of Accountability In Preserving Judicial Independence: Examining The Ethical Infrastructure Of The Federal Judicial Workplace, Susan Saab Fortney
The Role Of Accountability In Preserving Judicial Independence: Examining The Ethical Infrastructure Of The Federal Judicial Workplace, Susan Saab Fortney
Faculty Scholarship
After news reports of sexual harassment allegations involving federal judges, U.S. Supreme Court Chief Justice John Roberts asked the Director of the Administrative Office of the U.S. Courts to assemble a working group to address concerns related to misconduct in the federal judicial workplace. Following the working group’s report, the judiciary adopted recommendations relating to discrimination and harassment in the federal judiciary. Using the ethical infrastructure framework, this article reviews what changes have been made and what is missing. It explains how the steps taken largely focus on formal aspects of communicating and monitoring standards of conduct. Notably missing are …
The Second Amendment’S Second Sex, Michael Ulrich
The Second Amendment’S Second Sex, Michael Ulrich
Faculty Scholarship
This Essay explores how the Supreme Court’s Second Amendment doctrine perpetuates gender hierarchies and a male monopoly on lethal self-defense. It critiques the narrow “true man” framing that ignores women’s experiences and advocates for a justice-centered framework that incorporates power and privilege into the gun-rights discourse.
Seeing The Whole Together Through Relational Mapping: A Method For Engaging In Complex Systems Change, John Paul Stephens
Seeing The Whole Together Through Relational Mapping: A Method For Engaging In Complex Systems Change, John Paul Stephens
Faculty Scholarship
Complex global challenges cut across organizational and sectoral boundaries, increasing calls for holistic responses. Seeing the whole across diverse stakeholders is challenging for participants in complex systems, yet doing so is essential for engaging effectively in systems change. A promising new method known as relational mapping, based on relational coordination theory, has been used to facilitate complex systems change. Here, we propose that relational mapping can be applied to help participants (1) see the whole in relation to the parts, (2) share their explicit and tacit knowledge, (3) engage in dialogue across distinct perspectives supported by the map as a …
Self-Monitoring With Coping Skills And Lifestyle Education For Hypertension Control In Primary Care, Sonal J. Patil, Eno Obong Udoh
Self-Monitoring With Coping Skills And Lifestyle Education For Hypertension Control In Primary Care, Sonal J. Patil, Eno Obong Udoh
Faculty Scholarship
Self-monitoring with support, lifestyle modifications, and emotion management improves blood pressure (BP). Patients with hypertension need continual support to modify behaviors, but time pressures limit lifestyle education in primary care settings. Using mixed methods, we aimed to study the feasibility and acceptability of an innovative 6-week program that combined self-monitoring with coping skills and lifestyle education for patients with uncontrolled hypertension. Patients with uncontrolled hypertension interested in lifestyle modifications before intensifying medications were enrolled from primary care clinics. Patients self-monitored emotions, behaviors, and BPs and received education from medical providers and mind-body therapists through shared medical appointments (SMAs) with an …
Early Use Of Long-Acting Injectable Antipsychotics In Bipolar Disorder Type I: An Expert Consensus, Martha Sajatovic
Early Use Of Long-Acting Injectable Antipsychotics In Bipolar Disorder Type I: An Expert Consensus, Martha Sajatovic
Faculty Scholarship
Introduction: Long-acting injectable antipsychotics (LAIs) are not routinely offered to patients living with bipolar disorder type I (BP-I), despite widespread evidence that supports their benefits over oral antipsychotics, particularly in early disease. Methods: A round-table meeting of psychiatrists convened to discuss barriers and opportunities and provide consensus recommendations around the early use of LAIs for BP-I. Results: LAIs are rarely prescribed to treat BP-I unless a patient has severe symptoms, sub-optimal adherence to oral antipsychotics, or has experienced multiple relapses. Beyond country-specific accessibility issues (e.g., healthcare infrastructure and availability/approval status), primary barriers to the effective use of LAIs were identified …
Psychological And Social Well-Being Of Bony Fishes In Zoos And Aquariums (Ii), Ronald G. Oldfield
Psychological And Social Well-Being Of Bony Fishes In Zoos And Aquariums (Ii), Ronald G. Oldfield
Faculty Scholarship
Research on the behaviour of animals in zoos has been conducted for decades, and observations have provided information that has improved the psychological and social well-being of animals. However, research on fishes in zoos and aquariums seems to be lacking. Here, we assess the current state of research on fishes in zoos and aquariums by surveying the peer-reviewed literature. Our assessment differs from previous surveys in that we examine the taxonomic classes Chondrichthyes (sharks and rays) and Osteichthyes (bony fishes) separately. Our survey finds that bony fishes have been drastically underrepresented in zoo journals, more drastically than chondrichthyans, revealing an …
Low-Frequency Stimulation Of Corpus Callosum Suppresses Epileptiform Activity In The Cortex Through Γ-Aminobutyric Acid Type B Receptor And Slow Afterhyperpolarization-Mediated Reduction In Tissue Excitability, Nrupen Pakalapati, Chia Chu Chiang, Dominique M. Durand
Low-Frequency Stimulation Of Corpus Callosum Suppresses Epileptiform Activity In The Cortex Through Γ-Aminobutyric Acid Type B Receptor And Slow Afterhyperpolarization-Mediated Reduction In Tissue Excitability, Nrupen Pakalapati, Chia Chu Chiang, Dominique M. Durand
Faculty Scholarship
Objective: Deep brain stimulation, particularly low-frequency stimulation (LFS) targeting fiber tracts, has emerged as a potential therapy for drug-resistant epilepsy (DRE) and for generalized epilepsy, both of which pose significant treatment challenges. LFS diffusely suppresses seizures in the cortex when applied to fiber tracts like the corpus callosum (CC). Nevertheless, the specific processes responsible for suppressing epileptic activity in the cortex induced by LFS remain unclear. This study investigates the mechanisms underlying the antiepileptic effect in the cortex of LFS of the CC in coronal rodent brain slices. Methods: An in vitro 4-aminopyridine (4-AP) seizure model of cortical seizures was …
A Preliminary Review Of The Utility Of Artificial Intelligence To Detect Eosinophilic Chronic Rhinosinusitis, Ross Rosen, Daniel Karasik, John Richter, Claudia Cabrera, Brian D'Anza, Kenneth Rodriguez, Sanjeet V. Rangarajan
A Preliminary Review Of The Utility Of Artificial Intelligence To Detect Eosinophilic Chronic Rhinosinusitis, Ross Rosen, Daniel Karasik, John Richter, Claudia Cabrera, Brian D'Anza, Kenneth Rodriguez, Sanjeet V. Rangarajan
Faculty Scholarship
Key points: While typically diagnosed with biopsy, ECRS may be predicted preoperatively with the use of AI. Various AI models have been used, with pooled sensitivity of 0.857 and specificity of 0.850. We found no statistically significant difference between the accuracy of various AI models.
A Simple And Fast Optical Clearing Method For Whole-Mount Fluorescence In Situ Hybridization (Fish) Imaging, Junwoo Suh, Yehe Liu, Jordan Smith, Michiko Watanabe, Andrew M. Rollins, Michael W. Jenkins
A Simple And Fast Optical Clearing Method For Whole-Mount Fluorescence In Situ Hybridization (Fish) Imaging, Junwoo Suh, Yehe Liu, Jordan Smith, Michiko Watanabe, Andrew M. Rollins, Michael W. Jenkins
Faculty Scholarship
We report a single-step optical clearing method that is compatible with RNA fluorescence in situ hybridization (FISH) imaging. We previously demonstrated microscopy imaging with immunohistochemistry and genetic reporters using a technique called lipid-preserving refractive index matching for prolonged imaging depth (LIMPID). Our protocol reliably produces high-resolution three-dimensional (3D) images with minimal aberrations using high magnification objectives, captures large field-of-view images of whole-mount tissues, and supports co-labeling with antibody and FISH probes. We also custom-designed FISH probes for quail embryos, demonstrating the ease of fabricating probes for use with less common animal models. Furthermore, we show high-quality 3D images using a …
Study Of Am Electrodeposition From Amcl₃-Licl-Kci Molten Salt, Rohan Akolkar, Christine E. Duval
Study Of Am Electrodeposition From Amcl₃-Licl-Kci Molten Salt, Rohan Akolkar, Christine E. Duval
Faculty Scholarship
In this work, the electrodeposition reaction of Am in AmCl₃LiCl-KCl molten salt was studied using voltammetry and chronoamperometry. Electrodeposition of Am was shown to proceed via a two − step reaction scheme, involving the one-electron transfer reduction of Am³⁺ to Am²⁺, followed by the two-electron transfer reduction of intermediate Am²⁺ to Am⁰. A low Coulombic efficiency of Am deposition was measured despite the Am deposition occurring within the thermodynamic stability window of the supporting LiCl-KCl electrolyte. We hypothesize that the low efficiency is due to out-diffusion of the intermediate Am²⁺ species away from the electrode surface. Experimental observations provide evidence …
Introduction: Giving Room To Embodied Relationships, Jeremy D. Bendik-Keymer
Introduction: Giving Room To Embodied Relationships, Jeremy D. Bendik-Keymer
Faculty Scholarship
The special issue Z(a)dziwienie ciałem—to Wonder (to Wander) in Corporeal Relationships aims to contribute modestly and imaginatively to the recent wave of work around wonder. In some respects, too, it continues the short seminar “Discussing Wonder” published in Studia Philosophica Wratislaviensia vol. XV, no. 2 (2020). In the ancient Greek philosophical tradition, wonder helped philosophers make sense of the nature of their own inquiries and their striving for knowledge. This is the context in which Plato and Aristotle first discussed wonder (thaumadzein). The concept was reprised in a similar framework when Descartes and Spinoza laid foundations for modern philosophy, and …
Exploration Of Epileptic Networks In Temporal Lobe Encephaloceles With Stereotactic Eeg: Electroclinical Characteristics And Surgical Outcomes, Michael D. Staudt
Exploration Of Epileptic Networks In Temporal Lobe Encephaloceles With Stereotactic Eeg: Electroclinical Characteristics And Surgical Outcomes, Michael D. Staudt
Faculty Scholarship
Objective: Temporal lobe encephaloceles (TLEN) have been implicated as a cause of temporal lobe epilepsy (TLE), the treatment which is primarily surgical; however, there is no clear consensus on the optimal surgical approach, because it is unclear whether TLE related to TLEN can be addressed by a restricted encephalocele resection or if a more extensive resection is required. The aim of the current article is to report the clinical and electrophysiological profile of patients with TLE secondary to TLEN who underwent stereotactic electroencephalography (SEEG) implantation to identify the epileptogenic network. Methods: A retrospective review was performed of patients with TLE …
Proceedings Of The 2022 “Lifestyle Intervention For Epilepsy (Life)” Symposium Hosted By Cleveland Clinic, Martha Sajatovic
Proceedings Of The 2022 “Lifestyle Intervention For Epilepsy (Life)” Symposium Hosted By Cleveland Clinic, Martha Sajatovic
Faculty Scholarship
Lifestyle interventions are strategies used to self-manage medical conditions, such as epilepsy, and often complement traditional pharmacologic and surgical therapies. The need for integrating evidence-based lifestyle interventions into mainstream medicine for the treatment of epilepsy is evident given that despite the availability of a multitude of treatments with medications and surgical techniques, a significant proportion of patients have refractory seizures, and even those who are seizure-free report significant adverse effects with current treatments. Although the evidence base for complementary medicine is less robust than it is for traditional forms of medicine, the evidence to date suggests that several forms of …
Reducing Consumer–Brand Incongruity Through Corporate Social Responsibility And Brand Trust: Exploring Negative Word-Of- Mouth (Nwom), Petek Tosun, Sandy Ipeker Cagliyor, Merve Yanar Gürce
Reducing Consumer–Brand Incongruity Through Corporate Social Responsibility And Brand Trust: Exploring Negative Word-Of- Mouth (Nwom), Petek Tosun, Sandy Ipeker Cagliyor, Merve Yanar Gürce
Faculty Scholarship
Drawing upon consumer–brand disidentification theory and balance theory, this study examines symbolic and ideological incongruity in consumer–brand relationships through an original conceptual model shaped by negative past experiences, brand trust, perceived corporate social responsibility (CSR), and negative word-of- mouth (NWOM). A preliminary study was conducted to explore the dimensions of consumers' negative past experiences by topic detection. Latent Dirichlet allocation (LDA) topic modeling was undertaken to analyze online consumer reviews (n = 6095) about a coffee chain brand. The dimensions detected in this preliminary study were included in the research model and further analyzed in the main study. The main …
A High-Tech Wreck: Hipaa Roadblocks To Texting Patients, Jonathan Fanaroff
A High-Tech Wreck: Hipaa Roadblocks To Texting Patients, Jonathan Fanaroff
Faculty Scholarship
Protecting the private and confidential information entrusted to health care professionals is a core principle dating back to the Hippocratic Oath. At the same time, effective health communication is essential to build trust and allow patients and families to understand and participate as true members of the team. Although it is not often discussed, there can be a tension between legal security regulations designed to protect confidentiality and the ability to effectively communicate with families. The main source of this tension in the United States is related to the Health Insurance Portability and Accountability Act (HIPAA). At the dawn of …
Prazosin As An Adjuvant To Increase Effectiveness Of Duloxetine In A Rat Model Of Oxaliplatin-Induced Peripheral Neuropathy, Monica A. Wagner, Naji Ayyash
Prazosin As An Adjuvant To Increase Effectiveness Of Duloxetine In A Rat Model Of Oxaliplatin-Induced Peripheral Neuropathy, Monica A. Wagner, Naji Ayyash
Faculty Scholarship
Objectives: Duloxetine, the only American Society of Clinical Oncology (ASCO) treatment recommended for chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors, is not effective for 40% of survivors. This study examined the ability of a duloxetine-prazosin combination to prevent the development of allodynia and hyperalgesia in a rat model of oxaliplatin-induced peripheral neuropathy (OPIN). Methods: Female (n = 24) and male (n = 41) rats were started on duloxetine (15 mg), prazosin (2 mg), or a duloxetine-prazosin combination one week prior to administration of the chemotherapy drug, oxaliplatin, and continued the duloxetine-prazosin combination for 32 days. Behavioral testing for mechanical allodynia …
The International Legal Framework Of Oceanic Shipping Of Carbon Dioxide For Permanent Storage, Carolina Arlota, Michael B. Gerrard
The International Legal Framework Of Oceanic Shipping Of Carbon Dioxide For Permanent Storage, Carolina Arlota, Michael B. Gerrard
Faculty Scholarship
The Intergovernmental Panel on Climate Change defines carbon dioxide capture and storage (CCS) as “a process in which a relatively pure stream of carbon dioxide (CO2) from industrial and energy-related sources is separated (captured), conditioned, compressed, and transported to a storage location for long-term isolation from the atmosphere.” Therefore, CCS encompasses a series of steps, at minimum: capturing carbon dioxide, its transportation to a storage site, and its injection into the subsurface for permanent storage. As such, CCS does not refer to any single activity or technology. This Article focuses on the transportation aspect of CCS and, more precisely, …
Fail Fast, Fail Small: Designing Resilient Systems For The Future Of Software Engineering, Jill Willard, James Hutson
Fail Fast, Fail Small: Designing Resilient Systems For The Future Of Software Engineering, Jill Willard, James Hutson
Faculty Scholarship
The principles of "fail fast, fail small" have emerged as critical in modern software and system design. By planning for minor, manageable failures instead of catastrophic breakdowns, developers can ensure that systems degrade gracefully, maintaining functionality even when encountering issues. This article delves into strategies for designing resilient systems, beginning with the concept of slow degradation and distributed systems that prioritize core functions while allowing non-critical components to fail without significant user impact. The Netflix recommendation engine serves as a prime example of a system that continues to operate under failure conditions. Chaos engineering, a proactive methodology for stress-testing system …
Neurological Foundations And Technological Interventions For Dyslexia: Advancements And Challenges, Piper Hutson, James Hutson
Neurological Foundations And Technological Interventions For Dyslexia: Advancements And Challenges, Piper Hutson, James Hutson
Faculty Scholarship
Dyslexia, a complex neurological condition affecting reading and language processing, is intricately tied to variations in brain structure and function. This article explores the neurological underpinnings of dyslexia, emphasizing phonological, visual, and attention-related impairments. Furthermore, the analysis highlights various types of dyslexia—phonological, surface, rapid automatized naming, and visual—while addressing their neurological correlations. It also investigates the relationship between dyslexia and other neurodivergent conditions, such as autism and ADHD, focusing on the neurological overlap and differences. To mitigate the challenges associated with dyslexia, advanced technologies such as virtual reality (VR) and eye-tracking are discussed for their diagnostic and intervention potential. These …
Evolving Corporate Philanthropy, David I. Walker
Evolving Corporate Philanthropy, David I. Walker
Faculty Scholarship
With the rise of corporate ESG initiatives and public benefit corporations, corporate philanthropy is evolving from an emphasis on cash contributions (contributional philanthropy) to an emphasis on adjusting operations to advance the public good (operational philanthropy). All forms of corporate philanthropy are controversial, but this article evaluates the impact of this evolution on the relative benefits and concerns of corporate philanthropy, arguing that the shift in emphasis towards operational philanthropy increases the comparative advantage of corporate philanthropy, increases agency costs, both simplifies and complicates shareholder primacy concerns, and increases the difficulty of prescriptively regulating corporate philanthropy through the tax code …
Constitutional Disorder, Robert L. Tsai
Constitutional Disorder, Robert L. Tsai
Faculty Scholarship
This is a review essay inspired by two books: Yuval Levin's American Covenant (2024) and Erwin Chemerinsky's No Democracy Lasts Forever (2024). I make the following points. First, all treatments of the U.S. Constitution can be mapped on a continuum from the worshipful to the diagnostic. Second, Levin's account, which inclines toward the devotional, extols certain features deemed both originalist and virtuous: social unity over untidiness, consensus over dissent, fear and loathing of mass politics. Third, such accounts may not be sufficiently nimble to grapple with contemporary problems such as new forms of oligarchy or movement capture of traditional parties. …
How Do You Like Your Books, Jessica Silbey
How Do You Like Your Books, Jessica Silbey
Faculty Scholarship
Do you ever wonder how it is that libraries can lend books repeatedly, while copyright owners (e.g., book authors) are granted the exclusive right to distribute their copyrighted works? Or how publishers make money selling books at retail prices when a person can resell books (or buy used books) for much less (hello Amazon Used Books for under a dollar!)? The reason is because of copyright’s “first sale” doctrine, 17 U.S.C. § 109, codifying the common law’s exhaustion principle, which says owners of lawfully made copies are allowed to dispose of those copies without regard to copyright law. In other …
Melanism In Polymorphic Terrestrial Snakes: A Meta-Analysis And Systematic Review, Ryan A. Martin
Melanism In Polymorphic Terrestrial Snakes: A Meta-Analysis And Systematic Review, Ryan A. Martin
Faculty Scholarship
Background and Aim: Colour polymorphic populations constitute excellent model systems for testing ecological and evolutionary hypotheses, as alternate colourations are associated with differences in various biological, behavioural and life-history traits. Melanism is the most common and most obvious form of polymorphism. In reptiles in general (and snakes in particular), thermal melanism has been a popular hypothesis used to explain the appearance of black individuals. It suggests that a trade-off exists between superior thermoregulation and reduced protection through the loss of crypsis. Surprisingly, despite the growing body of literature available, to date, there are only two qualitative reviews on the evolutionary …
Synergistic Effects Of Biological Stimuli And Flexion Induce Microcavities Promote Hypertrophy And Inhibit Chondrogenesis During In Vitro Culture Of Human Mesenchymal Stem Cell Aggregates, Bo Zhang, Jim Berilla, Sungwoo Cho, Rodrigo A. Somoza, Jean F. Welter, Harihara Baskaran
Synergistic Effects Of Biological Stimuli And Flexion Induce Microcavities Promote Hypertrophy And Inhibit Chondrogenesis During In Vitro Culture Of Human Mesenchymal Stem Cell Aggregates, Bo Zhang, Jim Berilla, Sungwoo Cho, Rodrigo A. Somoza, Jean F. Welter, Harihara Baskaran
Faculty Scholarship
Interzone/cavitation are key steps in early stage joint formation that have not been successfully developed in vitro. Further, current models of endochondral ossification, an important step in early bone formation, lack key morphology morphological structures such as microcavities found during development in vivo. This is possibly due to the lack of appropriate strategies for incorporating chemical and mechanical stimuli that are thought to be involved in joint development. We designed a bioreactor system and investigated the synergic effect of chemical stimuli (chondrogenesis-inducing [CIM] and hypertrophy-inducing medium [HIM]) and mechanical stimuli (flexion) on the growth of human mesenchymal stem cells (hMSCs) …
Preferences For Attributes Of Oral Antipsychotic Treatments: Results From A Discrete-Choice Experiment In Respondents With Schizophrenia Or Bipolar I Disorder, Martha Sajatovic
Preferences For Attributes Of Oral Antipsychotic Treatments: Results From A Discrete-Choice Experiment In Respondents With Schizophrenia Or Bipolar I Disorder, Martha Sajatovic
Faculty Scholarship
Background: Antipsychotic medications are effective treatments for schizophrenia (SZ) and bipolar I disorder (BD-I), but when presented with different treatment options, there are tradeoffs that individuals make between clinical improvement and adverse effects. As new options become available, understanding the attributes of antipsychotic medications that are valued and the tradeoffs that individuals consider when choosing among them is important. Methods: A discrete-choice experiment (DCE) was administered online to elicit preferences across 5 attributes of oral antipsychotics: treatment efficacy (i.e., improvement in symptom severity), weight gain over 6 months, sexual dysfunction, sedation, and akathisia. Eligible respondents were aged 18–64 years with …
All You Need Is Unary: End-To-End Bit-Stream Processing In Hyperdimensional Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi
All You Need Is Unary: End-To-End Bit-Stream Processing In Hyperdimensional Computing, Mehran Shoushtari Moghadam, M. Hassan Najafi
Faculty Scholarship
Hyperdimensional Computing (HDC) is a brain-inspired computing paradigm introduced to achieve energy efficiency with a lightweight and single-pass training model. Hypervectors (HVs) at the heart of the HDC systems play a fundamental role in elevating the accuracy and obtaining the desired performance. Image-based HV encoding requires two types of HVs: Position and Level HVs. State-of-the-art approaches utilize pseudo-random methods for generating these HVs, which might degrade system performance and cause higher power consumption due to poor randomness in HV generation. These conventional methods require iteratively calculating orthogonal Positional HVs for acceptable accuracy. This work proposes a fast, ultra-lightweight, and high-quality …
Adaptive Worlds: Generative Ai In Game Design And Future Of Gaming, And Interactive Media, Jay Ratican, James Hutson
Adaptive Worlds: Generative Ai In Game Design And Future Of Gaming, And Interactive Media, Jay Ratican, James Hutson
Faculty Scholarship
Generative AI is revolutionizing the field of game design, introducing unprecedented adaptability and personalization in gameplay. The latest advancements in AI-driven engines enable real-time content creation, offering dynamic, player-driven experiences that diverge from traditional pre-programmed narratives. This shift marks a transition toward "choose your own adventure" formats, with an unlimited number of variations in levels, enemies, collectibles, and weaponry, tailored to each player's decisions. Google's GameNGen, for example, showcases AI's capacity to recreate classic games like DOOM, learning and generating gameplay in real time. These innovations are not restricted to gaming alone; they extend to edutainment, television, and film, where …
A Practical Guide To Light-Sheet Microscopy For Nanoscale Imaging: Looking Beyond The Cell, Stephanie N. Kramer, Jeanpun Antarasen, Cole R. Reinholt, Lydia Kisley
A Practical Guide To Light-Sheet Microscopy For Nanoscale Imaging: Looking Beyond The Cell, Stephanie N. Kramer, Jeanpun Antarasen, Cole R. Reinholt, Lydia Kisley
Faculty Scholarship
We present a comprehensive guide to light-sheet microscopy (LSM) to assist scientists in navigating the practical implementation of this microscopy technique. Emphasizing the applicability of LSM to image both static microscale and nanoscale features, as well as diffusion dynamics, we present the fundamental concepts of microscopy, progressing through beam profile considerations, to image reconstruction. We outline key practical decisions in constructing a home-built system and provide insight into the alignment and calibration processes. We briefly discuss the conditions necessary for constructing a continuous 3D image and introduce our home-built code for data analysis. By providing this guide, we aim to …
A 6-Month, Prospective, Randomized Controlled Trial Of Customized Adherence Enhancement Versus A Bipolar-Specific Educational Control In Poorly Adherent Adolescents And Young Adults Living With Bipolar Disorder, Jennifer B. Levin, Molly Mcvoy, Joy Yala, Jessica Black, Carla Conroy, Martha Sajatovic
A 6-Month, Prospective, Randomized Controlled Trial Of Customized Adherence Enhancement Versus A Bipolar-Specific Educational Control In Poorly Adherent Adolescents And Young Adults Living With Bipolar Disorder, Jennifer B. Levin, Molly Mcvoy, Joy Yala, Jessica Black, Carla Conroy, Martha Sajatovic
Faculty Scholarship
Objective: Few studies have addressed medication adherence in adolescents and young adults (AYAs) with bipolar disorder (BD). This 6-month prospective randomized-controlled trial (RCT) tested customized adherence enhancement for adolescents and young adults (CAE-AYA), a behavioral intervention for AYAs versus enhanced treatment as usual (ETAU). Methods: Inclusion criteria were AYAs age 13–21 with BD type I or II with suboptimal adherence defined as missing ≥20% of medications. Assessments were conducted at Screening, Baseline, and weeks 8, 12 and 24. Primary outcome was past 7 day self-reported Tablets Routine Questionnaire (TRQ) validated by electronic pillbox monitoring (SimpleMed). Symptom measures included the Hamilton …