Digital Commons Network^™

Local Translation Across Neural Development: A Focus On Radial Glial Cells, Axons, And Synaptogenesis, Manasu Agrawal, Kristy Welshhans

Faculty Publications

In the past two decades, significant progress has been made in our understanding of mRNA localization and translation at distal sites in axons and dendrites. The existing literature shows that local translation is regulated in a temporally and spatially restricted manner and is critical throughout embryonic and post-embryonic life. Here, recent key findings about mRNA localization and local translation across the various stages of neural development, including neurogenesis, axon development, and synaptogenesis, are reviewed. In the early stages of development, mRNAs are localized and locally translated in the endfeet of radial glial cells, but much is still unexplored about their …

Swir Emissive Rosindolizine Dyes With Nanoencapsulation In Water Soluble Dendrimers, Satadru Chatterjee, William E. Meador, Cameron Smith, Indika Chandrasiri, Mohammad Farid Zia, Jay Nguyen, Austin Dorris, Alex Flynt, Davita L. Watkins, Nathan I. Hammer, Jared H. Delcamp

Faculty Publications

Shortwave infrared (SWIR) emission has great potential for deep-tissue in vivo biological imaging with high resolution. In this article, the synthesis and characterization of two new xanthene-based RosIndolizine dyes coded ^PhRosIndz and ^tolRosIndz is presented. The dyes are characterized via femtosecond transient absorption spectroscopy as well as steady-state absorption and emission spectroscopies. The emission of these dyes is shown in the SWIR region with peak emission at 1097 nm. ^TolRosIndz was encapsulated with an amphiphilic linear dendritic block co-polymer (LDBC) coded 10-PhPCL-G3 with high uptake yield. Further, cellular toxicity was examined in vitro using HEK (human embryonic …

Covid-19 Protocols In Academic Libraries In Canada And The United States: An Acrl Val Report, Holt Zaugg, Jeffrey Bullington, Stephanie Farne, Beate Gersch, Jo Ann Murphy, Lamonica Sanford

Faculty Publications

In the Fall of 2020, as the COVID-19 pandemic raged throughout the world, educational institutions pivoted to online learning and supporting services, especially those found in academic libraries, adjusted. To better understand measures taken by academic libraries in Canada and the United States, the Association of College & Research Libraries’ (ACRL) Value of Academic Libraries (VAL) committee formed a subcommittee to examine how academic libraries adjusted and provided services to their respective institutions during COVID-19 pandemic. This report is the culmination of this examination.

Measuring Routine Childhood Vaccination Coverage In 204 Countries And Territories, 1980–2019: A Systematic Analysis For The Global Burden Of Disease Study 2020, Release 1, Natalie C. Galles, Patrick Y. Liu, Rachel L. Updike, Nancy Fullman, Jason Nguyen, Sam Rolfe, Ismaeel Yunusa, Et Al.

Faculty Publications

Background

Methods

Covid-19 Disrupted Provision And Utilization Of Health And Nutrition Services In Uttar Pradesh, India: Insights From Service Providers, Household Phone Surveys, And Administrative Data, Phuong H. Nguyen, Shivani Kachwaha, Anjali Pant, Lan M. Tran, Monika Walia, Sebanti Ghosh, Praveen K. Sharma, Jessica Escobar-Alegria, Edward A. Frongillo Jr., Purnima Menon, Rasmi Avula

Faculty Publications

BACKGROUND: The coronavirus (COVID-19) pandemic may substantially affect health systems, but little primary evidence is available on disruption of health and nutrition services. OBJECTIVES: This study aimed to 1) determine the extent of disruption in provision and utilization of health and nutrition services induced by the pandemic in Uttar Pradesh, India; and 2) identify how adaptations were made to restore service provision in response to the pandemic. METHODS: We conducted longitudinal surveys with frontline workers (FLWs, n = 313) and mothers of children < 2 y old (n = 659) in December 2019 (in-person) and July 2020 (by phone). We also interviewed block-level managers and obtained administrative data. We examined changes in service provision and utilization using Wilcoxon matched-pairs signed-rank tests. RESULTS: Compared with prepandemic, service provision reduced substantially during lockdown (83-98 percentage points, pp), except for home visits and take-home rations (∼ 30%). Most FLWs (68%-90%) restored service provision in July 2020, except for immunization and hot cooked meals (< 10%). Administrative data showed similar patterns of disruption and restoration. FLW fears, increased workload, inadequate personal protective equipment (PPE), and manpower shortages challenged service provision. Key adaptations made to provide services were delivering services to beneficiary homes (∼ 40%-90%), social distancing (80%), and using PPE (40%-50%) and telephones for communication (∼ 20%). On the demand side, service utilization reduced substantially (40-80 pp) during the lockdown, but about half of mothers received home visits and food supplementation. Utilization for most services did not improve after the lockdown, bearing the challenges of limited travel (30%), nonavailability of services (26%), and fear of catching the virus when leaving the house (22%) or meeting service providers (14%). CONCLUSIONS: COVID-19 disrupted the provision and use of health and nutrition services in Uttar Pradesh, India, despite adaptations to restore services. Strengthening logistical support, capacity enhancement, performance management, and demand creation are needed to improve service provision and utilization during and post-COVID-19.

An Assessment Of Government Capacity Building To Restrict The Marketing Of Unhealthy Food And Non-Alcoholic Beverage Products To Children In The Region Of The Americas, Sofía Rincón-Gallardo Patiño, Fabio Da Silva Gomes, Steven Constantinou, Robin Lemaire, Valisa E. Hedrick, Elena L. Serrano, Vivica I. Kraak

Faculty Publications

No abstract provided.

Ca Special Issue On Neural Network Approximation, Wolfgang Dahmen, Ronald A. Devore, Philipp Grohs

Faculty Publications

No abstract provided.

The Brass Plates In Context: A Book Of Mormon Backstory, Noel B. Reynolds

Faculty Publications

This paper brings contemporary ANE scholarship in several fields together with the ancient scriptures restored through Joseph Smith to construct an updated starting point for interpretation of the teachings of the Book of Mormon. It assembles findings from studies of ancient scribal culture, historical linguistics and epigraphy, and the history and archaeology of Mesopotamia, Egypt, and the Levant, together with the traditions of ancient Israel and the ancient scriptures restored to Joseph Smith, to construct a contextualized perspective for understanding Lehi, Nephi, and the Brass Plates as they would have been understood by their contemporaries—as prominent bearers of the Josephite …

Comparative Efficacy, Safety, Tolerability, And Effectiveness Of Antipsychotics In The Treatment Of Dementia-Related Psychosis (Drp): A Systematic Literature Review, Ismaeel Yunusa, N. Rashid, V. Abler, Krithika Rajagopalan

Faculty Publications

Objectives

To evaluate the comparative efficacy, safety, tolerability, and effectiveness of atypical antipsychotics (AAPs) for the treatment of dementia related psychosis (DRP) in older adults.

Methods

In this systematic literature review (SLR), we qualitatively synthesized evidence on the comparative efficacy (based on neuropsychiatric inventory), tolerability (weight gain), and safety (cerebrovascular adverse events [CVAE], cardiovascular events, mortality, somnolence, extrapyramidal symptoms [EPS]) of AAPs used to treat DRP. We also assessed effectiveness based on all-cause discontinuations and discontinuations due to lack of efficacy or adverse events (AE). Published articles from through March 2021 from PubMed, EMBASE, PsycINFO, and Cochrane databases evaluated. We …

Rapid Computation Of Effective Conductivity Of 2d Composites By Equivalent Circuit And Spectral Methods., Ben J. Ransom, Dean R. Wheeler

Faculty Publications

This work presents models for homogenizing or finding the effective transport or mechanical properties of microscale composites formed from highly contrasting phases described on a grid. The methods developed here are intended for engineering applications where speed and geometrical flexibility are a premium. A canonical case that is mathematically challenging and yet can be applied to many realistic materials is a 4-phase 2-dimensional periodic checkerboard or tiling. While analytic solutions for calculating effective properties exist for some cases, versatile methods are needed to handle anisotropic and non-square grids. A reinterpretation and extension of an existing analytic solution that utilizes equivalent …

Odt Flow: Extracting, Analyzing, And Sharing Multi-Source Multi-Scale Human Mobility, Zhenlong Li, Xiao Huang, Tao Hu, Huan Ning, Xinyue Ye, Binghu Huang, Xiaoming Li

Faculty Publications

In response to the soaring needs of human mobility data, especially during disaster events such as the COVID-19 pandemic, and the associated big data challenges, we develop a scalable online platform for extracting, analyzing, and sharing multi-source multi-scale human mobility flows. Within the platform, an origin-destination-time (ODT) data model is proposed to work with scalable query engines to handle heterogenous mobility data in large volumes with extensive spatial coverage, which allows for efficient extraction, query, and aggregation of billion-level origin-destination (OD) flows in parallel at the server-side. An interactive spatial web portal, ODT Flow Explorer, is developed to allow users …

High-Throughput Discovery Of Novel Cubic Crystal Materials Using Deep Generative Neural Networks, Yong Zhao, Mohammed Al-Fahdi, Ming Hu, Edirisuriya M.D. Siriwardane, Yuqi Song, Alireza Nasiri, Jianjun Hu

Faculty Publications

High-throughput screening has become one of the major strategies for the discovery of novel functional materials. However, its effectiveness is severely limited by the lack of sufficient and diverse materials in current materials repositories such as the open quantum materials database (OQMD). Recent progress in deep learning have enabled generative strategies that learn implicit chemical rules for creating hypothetical materials with new compositions and structures. However, current materials generative models have difficulty in generating structurally diverse, chemically valid, and stable materials. Here we propose CubicGAN, a generative adversarial network (GAN) based deep neural network model for large scale generative design …

Individualized Response To Semantic Versus Phonological Aphasia Therapies In Stroke, Sigfus Kristinsson, Alexandra Basilakos, Jordan Elm, Leigh Ann Spell, Leonardo Bonilha, Chris Rorden, Dirk Den Ouden Ph.D., Christy Cassarly, Souvik Sen, Argye Hillis, Gregory Hickok, Julius Fridriksson Ph.D.

Faculty Publications

Attempts to personalize aphasia treatment to the extent where it is possible to reliably predict individual response to a particular treatment have yielded inconclusive results. The current study aimed to (i) compare the effects of phonologically versus semantically focussed naming treatment and (ii) examine biographical and neuropsychological baseline factors predictive of response to each treatment. One hundred and four individuals with chronic post-stroke aphasia underwent 3 weeks of phonologically focussed treatment and 3 weeks of semantically focussed treatment in an unblinded cross-over design. A linear mixed-effects model was used to compare the effects of treatment type on proportional change in …

“Covid-19 Hospital Isolation Affects More Than Just The Sick”, Lisa M. Tillmann Ph.D.

Faculty Publications

The author faces total hip replacement amid COVID-19 restrictions, politics, and disinformation.

Spatial Disparities Of Covid-19 Cases And Fatalities In United States Counties, Sarah L. Jackson, Sahar Derakhshan, Leah Blackwood, Logan Lee, Qian Huang, Margot Habets, Susan L. Cutter

Faculty Publications

This paper examines the spatial and temporal trends in county-level COVID-19 cases and fatalities in the United States during the first year of the pandemic (January 2020–January 2021). Statistical and geospatial analyses highlight greater impacts in the Great Plains, Southwestern and Southern regions based on cases and fatalities per 100,000 population. Significant case and fatality spatial clusters were most prevalent between November 2020 and January 2021. Distinct urban–rural differences in COVID-19 experiences uncovered higher rural cases and fatalities per 100,000 population and fewer government mitigation actions enacted in rural counties. High levels of social vulnerability and the absence of mitigation …

Thermal Legacy Of A Large Paleolake In Taylor Valley, East Antarctica, As Evidenced By An Airborne Electromagnetic Survey, Krista F. Myers, Peter T. Doran, Slawek M. Tulaczyk, Neil T. Foley, Thue S. Bording, Esben Auken, Hilary A. Dugan, Jill A. Mikucki, Nikolaj Foged, Denys Grombacher, Ross A. Virginia

Faculty Publications

Previous studies of the lakes of the McMurdo Dry Valleys have attempted to constrain lake level history, and results suggest the lakes have undergone hundreds of meters of lake level change within the last 20ĝ€¯000 years. Past studies have utilized the interpretation of geologic deposits, lake chemistry, and ice sheet history to deduce lake level history; however a substantial amount of disagreement remains between the findings, indicating a need for further investigation using new techniques. This study utilizes a regional airborne resistivity survey to provide novel insight into the paleohydrology of the region. Mean resistivity maps revealed an extensive brine …

Associations Between Fasting Duration, Timing Of First And Last Meal, And Cardiometabolic Endpoints In The National Health And Nutrition Examination Survey, Michael David Wirth, Longgang Zhao, Gabrielle Turner-Mcgrievy, Andrew Ortaglia

Faculty Publications

Background: Research indicates potential cardiometabolic benefits of energy consumption earlier in the day. This study examined the association between fasting duration, timing of first and last meals, and cardiometabolic endpoints using data from the National Health and Nutrition Examination Survey (NHANES). Methods: Cross-sectional data from NHANES (2005–2016) were utilized. Diet was obtained from one to two 24-h dietary recalls to characterize nighttime fasting duration and timing of first and last meal. Blood samples were obtained for characterization of C-reactive protein (CRP); glycosylated hemoglobin (HbA1c %); insulin; glucose; and high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol. Survey design procedures …

Automatic Calibration For Ce-Qual-W2 Model Using Improved Global-Best Harmony Search Algorithm, Afshin Shabani, Xiaodong Zhang, Xuefeng Chu, Haochi Zheng

Faculty Publications

CE-QUAL-W2 is widely used for simulating hydrodynamics and water quality of the aquatic environments. Currently, the model calibration is mainly based on trial and error, and therefore it is subject to the knowledge and experience of users. The Particle Swarm Optimization (PSO) algorithm has been tested for automatic calibration of CE-QUAL-W2, but it has an issue of prematurely converging to a local optimum. In this study, we proposed an Improved Global-Best Harmony Search (IGHS) algorithm to automatically calibrate the CE-QUAL-W2 model to overcome these shortcomings. We tested the performance of the IGHS calibration method by simulating water temperature of Devils …

12 C(E,E'Pn) Measurements Of Short Range Correlations In The Tensor-To-Scalar Interaction Transition Region, I. Korover, J. R. Pybus, A. Schmidt, F. Hauenstein, M. Duer, O. Hen, E. Piasetzky, L. B. Weinstein, D. W. Higinbotham, S. Adhikari, K. Adhikari, M. J. Amaryan, Giovanni Angelini, H. Atac, L. Barion, M. Battaglieri, A. Beck, I. Bedlinkskiy, Fatiha Benmokhtar, Steffen Strauch, Ralf W. Gothe, Krishna Chandra Neupane, Et. Al.

Faculty Publications

High-momentum configurations of nucleon pairs at short-distance are probed using measurements of the C-12(e, e' p) and C-12(e, e' pN) reactions (where N is either n or p), at high-Q(2) and x(B) > 1.1. The data span a missing-momentum range of 300-1000 MeV/c and are predominantly sensitive to the transition region of the strong nuclear interaction from a Tensor to Scalar interaction. The data are well reproduced by theoretical calculations using the Generalized Contact Formalism with both chiral and phenomenological nucleon-nucleon (NN) interaction models. This agreement suggests that the measured high missing-momentum protons up to 1000 MeV/c predominantly belong to short-ranged …

Multi-Gaussian Random Variables For Modeling Optical Phenomena, Olga Korotkova, Milo W. Hyde Iv

Faculty Publications

A generalization of the classic Gaussian random variable to the family of multi-Gaussian (MG) random variables characterized by shape parameter M > 0, in addition to the mean and the standard deviation, is introduced. The probability density function (PDF) of the MG family members is an alternating series of Gaussian functions with suitably chosen heights and widths. In particular, for integer values of M, the series has a finite number of terms and leads to flattened profiles, while reducing to the classic Gaussian PDF for M = 1. For non-integer, positive values of M, a convergent infinite series of …

Factors Influencing Physicians’ Continuous Blogging: A Survey, I. Chiu Chang, Kuei Chen Cheng, Hui Mei Hsu, David C. Yen

Faculty Publications

Background: Health information can be more easily transmitted and diffused through the Internet, but questionable online health information often misinforms patients. Physicians have a duty to inform patients how to achieve positive health outcomes. Many physicians often write blogs to provide patients with the right health information. However, most articles available on this sub-ject only describe the blog phenomena without providing a theoretical background and an empirical analysis of doctors using blogs. Methods: This study based on social cognitive theory (SCT) explores the factors influencing physicians’ intention of continuously blogging. A total of 887 physician blog-gers were invited to participate …

The Role Of Dnd1 In Cancers, Yun Zhang, Jyotsna D. Godavarthi, Abie Williams-Villalobo, Shahrazad Polk, Angabin Matin

Faculty Publications

The Ter mutation in Dead-End 1 (Dnd1), Dnd1Ter, which leads to a premature stop codon, has been determined to be the cause for primordial germ cell deficiency, accompanied with a high incidence of congenital testicular germ cell tumors (TGCTs) or teratomas in the 129/Sv-Ter mice. As an RNA-binding protein, DND1 can bind the 3′-untranslated region (3′-UTR) of mRNAs and function in translational regulation. DND1 can block microRNA (miRNA) access to the 3′-UTR of target mRNAs, thus inhibiting miRNA-mediated mRNA degradation and up-regulating translation or can also function to degrade or repress mRNAs. Other mechanisms of DND1 activity include promoting translation …

Probiotics In Prevention And Treatment Of Covid-19: Current Perspective And Future Prospects, Shilia Jacob Kurian, Mazhuvancherry Kesavan Unnikrishnan, Sonal Sekhar Miraj, Debasis Bagchi, Mithu Banerjee, B. Shrikar Reddy, Gabriel Sunil Rodrigues, Mohan K. Manu, Kavitha Saravu, Chiranjay Mukhopadhyay, Mahadev Rao

Faculty Publications

Saving lives and flattening the curve are the foremost priorities during the ongoing pandemic spread of SARS-CoV-2. Developing cutting-edge technology and collating available evidence would support frontline health teams. Nutritional adequacy improves general health and immunity to prevent and assuage infections. This review aims to outline the potential role of probiotics in fighting the COVID-19 by covering recent evidence on the association between microbiota, probiotics, and COVID-19, the role of probiotics as an immune-modulator and antiviral agent. The high basic reproduction number (R0) of SARS-CoV-2, absence of conclusive remedies, and the pleiotropic effect of probiotics in fighting influenza and other …

Spatiotemporal Trends And Variability In The Centroid Of The Northern Hemisphere's Circumpolar Vortex, Nazla Bushra, Robert V. Rohli

Faculty Publications

Recent previous research has established the "sharpest gradient" approach to defining the circumpolar vortex and has identified correlations of the area and circularity of the Northern Hemisphere's circumpolar vortex (NHCPV) to important atmospheric-oceanic teleconnections. However, because geographical shifts in the NHCPV, independent of area or circularity changes, could affect surface environmental conditions, this research addresses the question of the extent to which the NHCPV centroid undergoes such shifts, both intra- and inter-annually. Results show that during the 1979-2017 period, the centroid has moved less on a daily basis in more recent years, perhaps indicative of a stabilization in circulation, with …

Resource Theory Of Unextendibility And Nonasymptotic Quantum Capacity (), Eneet Kaur, Siddhartha Das, Mark M. Wilde, Andreas Winter

Faculty Publications

In this paper, we introduce the resource theory of unextendibility as a relaxation of the resource theory of entanglement. The free states in this resource theory are the -extendible states, associated with the inability to extend quantum entanglement in a given quantum state to multiple parties. The free channels are -extendible channels, which preserve the class of -extendible states. We define several quantifiers of unextendibility by means of generalized divergences and establish their properties. By utilizing this resource theory, we obtain nonasymptotic upper bounds on the rate at which quantum communication or entanglement preservation is possible over a finite number …

Symmetric Distinguishability As A Quantum Resource, Robert Salzmann, Nilanjana Datta, Gilad Gour, Xin Wang, Mark M. Wilde

Faculty Publications

We develop a resource theory of symmetric distinguishability, the fundamental objects of which are elementary quantum information sources, i.e. sources that emit one of two possible quantum states with given prior probabilities. Such a source can be represented by a classical-quantum state of a composite system XA, corresponding to an ensemble of two quantum states, with X being classical and A being quantum.We study the resource theory for two different classes of free operations: (i)CPTPA, which consists of quantum channels acting only on A, and (ii) conditional doubly stochastic maps acting on XA.We introduce the notion of symmetric distinguishability of …

Epicuticular Wax Rice Mutants Show Reduced Resistance To Rice Water Weevil (Coleoptera: Curculionidae) And Fall Armyworm (Lepidoptera: Noctuidae), Lina Bernaola, Timothy S. Butterfield, Thomas H. Tai, Michael J. Stout

Faculty Publications

Plant structural traits can act as barriers for herbivore attachment, feeding, and oviposition. In particular, epicuticular waxes (EWs) on the aerial surfaces of many land plants offer protection from biotic and abiotic stresses. In rice (Oryza sativa L.), mutations that reduce EWs have been previously reported. However, whether such mutations affect rice water weevil (Lissorhoptrus oryzophilus Kuschel) and fall armyworm (Spodoptera frugiperda Smith) performance has not been investigated yet. These pests cause significant economic problems in important rice-producing areas of the United States. The aim of our study was to characterize the EWs of EW mutants and wild-type rice plants …

Chemical Or Genetic Alteration Of Proton Motive Force Results In Loss Of Virulence Of Burkholderia Glumae, The Cause Of Rice Bacterial Panicle Blight, Asif Iqbal, Pradip R. Panta, John Ontoy, Jobelle Bruno, Jong Hyun Ham, William T. Doerrler

Faculty Publications

Rice is an important source of food for more than half of the world’s population. Bacterial panicle blight (BPB) is a disease of rice characterized by grain discoloration or sheath rot caused mainly by Burkholderia glumae. B. glumae synthesizes toxoflavin, an essential virulence factor that is required for symptoms of the disease. The products of the tox operons, ToxABCDE and ToxFGHI, are responsible for the synthesis and the proton motive force (PMF)-dependent secretion of toxoflavin, respectively. The DedA family is a highly conserved membrane protein family found in most bacterial genomes that likely function as membrane transporters. Our previous work …

Performance Of Bt-Susceptible And -Heterozygous Dual-Gene Resistant Genotypes Of Spodoptera Frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) In Seed Blends Of Non-Bt And Pyramided Bt Maize, Marcelo Dimase, Sebe Brown, Graham P. Head, Paula A. Price, Wade Walker, Wenbo Yu, Fangneng Huang

Faculty Publications

A seed blend refuge has been implemented in the U.S. Corn Belt for Bt maize resistance management. The fall armyworm, Spodoptera frugiperda (J.E. Smith), is a target pest of Bt maize in the Americas. The larvae of this pest are mobile, which may affect the efficacy of seed blend refuges. In this study, field and greenhouse trials were conducted to determine the performance of Bt-susceptible (aabb) and -heterozygous dual-gene-resistant (AaBb) genotypes of S. frugiperda in seed blends of non-Bt and pyramided Bt maize. Three field trials evaluated larval survival, larval growth, and plant injury with aabb in seed blends of …

Biocontrol Of Wireworms (Coleoptera: Elateridae) Using Entomopathogenic Nematodes: The Impact Of Infected Host Cadaver Application And Soil Characteristics, Ramandeep Kaur Sandhi, David Shapiro-Ilan, Michael Ivie, Gadi V.P. Reddy

Faculty Publications

Wireworms have become a significant menace to cereals in the Northern Great Plains. Therefore, research toward developing effective control methods such as biological control with entomopathogenic nematodes (EPNs) is warranted. Two strains, each of two EPN species, Steinernema carpocapsae (Weiser) and Steinernema riobrave Cabanillas, Poinar, and Raulston in the form of infected Galleria mellonella (L.) cadavers were evaluated against wireworms in field and greenhouse. In field experiments, none of the four EPN strains were found effective against wireworms. However, in the greenhouse test, three of the strains, S. carpocapsae (All and Cxrd) or S. riobrave (355) applied in cadavers killed …