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Articles 7831 - 7860 of 45765
Full-Text Articles in Entire DC Network
Assessment Of Risks To Listed Species From The Use Of Atrazine In The Usa: A Perspective, Philip N. Smith, Kevin L. Armbrust, Richard A. Brain, Wenlin Chen, Nika Galic, Lula Ghebremichael, Jeffrey M. Giddings, Mark L. Hanson, Jonathan Maul, Glen Van Der Kraak, Keith R. Solomon
Assessment Of Risks To Listed Species From The Use Of Atrazine In The Usa: A Perspective, Philip N. Smith, Kevin L. Armbrust, Richard A. Brain, Wenlin Chen, Nika Galic, Lula Ghebremichael, Jeffrey M. Giddings, Mark L. Hanson, Jonathan Maul, Glen Van Der Kraak, Keith R. Solomon
Faculty Publications
No abstract provided.
Heteroacene-Based Amphiphile As A Molecular Scaffold For Bioimaging Probes, Tharindu A. Ranathunge, Mahesh Loku Yaddehige, Jordan H. Varma, Cameron Smith, Jay Nguyen, Iyanuoluwani Owolabi, Wojciech Kolodziejczyk, Nathan I. Hammer, Glake Hill, Alex Flynt, Davita L. Watkins
Heteroacene-Based Amphiphile As A Molecular Scaffold For Bioimaging Probes, Tharindu A. Ranathunge, Mahesh Loku Yaddehige, Jordan H. Varma, Cameron Smith, Jay Nguyen, Iyanuoluwani Owolabi, Wojciech Kolodziejczyk, Nathan I. Hammer, Glake Hill, Alex Flynt, Davita L. Watkins
Faculty Publications
The challenges faced with current fluorescence imaging agents have motivated us to study two nanostructures based on a hydrophobic dye, 6H-pyrrolo[3,2-b:4,5-b’]bis [1,4]benzothiazine (TRPZ). TRPZ is a heteroacene with a rigid, pi-conjugated structure, multiple reactive sites, and unique spectroscopic properties. Here we coupled TRPZ to a tert-butyl carbamate (BOC) protected 2,2-bis(hydroxymethyl)propanoic acid (bisMPA) dendron via azide-alkyne Huisgen cycloaddition. Deprotection of the protected amine groups on the dendron afforded a cationic terminated amphiphile, TRPZ-bisMPA. TRPZ-bisMPA was nanoprecipitated into water to obtain nanoparticles (NPs) with a hydrodynamic radius that was TRPZ-PG was encapsulated in pluronic-F127 (Mw …
Probabilistic Rainfall Generator For Tropical Cyclones Affecting Louisiana, Gabriele Villarini, Wei Zhang, Paul Miller, David R. Johnson, Lauren E. Grimley, Hugh J. Roberts
Probabilistic Rainfall Generator For Tropical Cyclones Affecting Louisiana, Gabriele Villarini, Wei Zhang, Paul Miller, David R. Johnson, Lauren E. Grimley, Hugh J. Roberts
Faculty Publications
No abstract provided.
Ion-Dependent Dna Configuration In Bacteriophage Capsids, Pei Liu, Javier Arsuaga, M. Carme Calderer, Dmitry Golovaty, Mariel Vazquez, Shawn Walker
Ion-Dependent Dna Configuration In Bacteriophage Capsids, Pei Liu, Javier Arsuaga, M. Carme Calderer, Dmitry Golovaty, Mariel Vazquez, Shawn Walker
Faculty Publications
Bacteriophages densely pack their long double-stranded DNA genome inside a protein capsid. The conformation of the viral genome inside the capsid is consistent with a hexagonal liquid crystalline structure. Experiments have confirmed that the details of the hexagonal packing depend on the electrochemistry of the capsid and its environment. In this work, we propose a biophysical model that quantifies the relationship between DNA configurations inside bacteriophage capsids and the types and concentrations of ions present in a biological system. We introduce an expression for the free energy that combines the electrostatic energy with contributions from bending of individual segments of …
Lehi's Dream: Nephi's Blueprint, Noel B. Reynolds
Lehi's Dream: Nephi's Blueprint, Noel B. Reynolds
Faculty Publications
This essay harnesses the late twentieth-century discovery of Hebrew rhetoric by Bible scholars to identify Lehi’s dream as the foundation of the carefully constructed unity in Nephi’s writings and to identify previously unrecognized elements of that dream that are distributed throughout his final work. All the teachings and prophecies in First and Second Nephi are shown to derive from that dream/vision. Further, the entirety of Nephi’s writings in the small plates are shown to be a tightly designed rhetorical production that establishes the centrality of Christ’s identity, mission, and teachings for current and future generations of Lehi’s descendants and ultimately …
Modern Archaeology And The Brass Plates, Noel B. Reynolds
Modern Archaeology And The Brass Plates, Noel B. Reynolds
Faculty Publications
Contemporary Palestinian archaeology has produced two major threats to traditional interpretations of the history of ancient Israel. Scientific discomfort with the exodus story as an explanation for the sudden population expansion in southern Palestine at the beginning of the Iron Age (c.1200 BCE) has led to a wide variety of theories about how these Israelites could have been drawn from existing populations in the general area. And a glaring mismatch between the biblical glorification of David and Solomon’s “empire” and disparagement of the northern kingdom combined with the archaeological finding that the cities of the northern kingdom were far larger …
Electrochemical Micro-Aptasensors For Exosome Detection Based On Hybridization Chain Reaction Amplification, Wenfen Zhang, Zhenhua Tian, Shujie Yang, Joseph Rich, Shuaiguo Zhao, Mikael Klingeborn, Po-Hsun Huang, Zhishang Li, Alexander Stout, Quinn Murphy, Edward Patz, Shusheng Zhang, Guozhen Liu, Tony Jun Huang
Electrochemical Micro-Aptasensors For Exosome Detection Based On Hybridization Chain Reaction Amplification, Wenfen Zhang, Zhenhua Tian, Shujie Yang, Joseph Rich, Shuaiguo Zhao, Mikael Klingeborn, Po-Hsun Huang, Zhishang Li, Alexander Stout, Quinn Murphy, Edward Patz, Shusheng Zhang, Guozhen Liu, Tony Jun Huang
Faculty Publications
Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry, such as nucleic acids and proteins. However, most existing exosome-based analytical sensing methods struggle to achieve high sensitivity and high selectivity simultaneously. In this work, we present an electrochemical micro-aptasensor for the highly sensitive detection of exosomes by integrating a micropatterned electrochemical aptasensor and a hybridization chain reaction (HCR) signal amplification method. Specifically, exosomes are enriched on CD63 aptamer-functionalized electrodes and then recognized by HCR products with avidin-horseradish peroxidase (HRP) attached using EpCAM aptamers as …
An Everlasting Witness: Ancient Writings On Metal, Noel B. Reynolds
An Everlasting Witness: Ancient Writings On Metal, Noel B. Reynolds
Faculty Publications
After reviewing and updating the best studies of writing on metals in the ancient world, the paper examines scholarly and scriptural texts that explain what writing on metal meant to ancient scribes. Finally, the paper turns to what writing on metal meant to the Nephites.
Lehi And Nephi As Trained Manassite Scribes, Noel B. Reynolds
Lehi And Nephi As Trained Manassite Scribes, Noel B. Reynolds
Faculty Publications
This paper brings contemporary ANE scholarship in several fields together to construct an updated starting point for interpretation of the teachings of the Book of Mormon. It assembles findings from studies of ancient scribal culture, historical linguistics and epigraphy, Hebrew rhetoric, and the history and archaeology of Mesopotamia, Egypt, and the Levant, together with the traditions of ancient Israel to construct a contextualized perspective for understanding Lehi, Nephi, and their scribal training as they would have been understood by their contemporaries. Lehi and Nephi are shown to be the beneficiaries of the most advanced scribal training available in 7th century …
Nephi's Small Plates: A Rhetorical Analysis, Noel B. Reynolds
Nephi's Small Plates: A Rhetorical Analysis, Noel B. Reynolds
Faculty Publications
Readers of the Book of Mormon commonly assume the adequacy of a simple and straight-forward explanation for the existence of Nephi’s Small Plates. As explained at various points in the text, Nephi had undertaken a shorter version of his Large Plates record by selecting out the spiritual teachings, prophecies and revelations for a more focused presentation. But the adequacy of that explanation has come under considerable strain from two very different directions. In 1986 Fred Axelgard advanced the idea that the description provided for the Large Plates of Nephi as being more historical also applied to all of First Nephi …
Dirac-Born-Infeld Warm Inflation Realization In The Strong Dissipation Regime, Meysam Motaharfar, Rudnei O. Ramos
Dirac-Born-Infeld Warm Inflation Realization In The Strong Dissipation Regime, Meysam Motaharfar, Rudnei O. Ramos
Faculty Publications
We consider warm inflation with a Dirac-Born-Infeld (DBI) kinetic term in which both the non-equilibrium dissipative particle production and the sound speed parameter slow the motion of the inflaton field. We find that a low sound speed parameter removes, or at least strongly suppresses, the growing function appearing in the scalar of curvature power spectrum of warm inflation, which appears due to the temperature dependence in the dissipation coefficient. As a consequence of that, a low sound speed helps to push warm inflation into the strong dissipation regime, which is an attractive regime from a model building and phenomenological perspective. …
Thunderstorms Producing Sferic-Geolocated Gamma-Ray Flashes Detected By Tetra-Ii, Deirdre Smith, Jill Trepanier, Samer T. Alnussirat, Michael L. Cherry, Marc D. Legault, Donald J. Pleshinger
Thunderstorms Producing Sferic-Geolocated Gamma-Ray Flashes Detected By Tetra-Ii, Deirdre Smith, Jill Trepanier, Samer T. Alnussirat, Michael L. Cherry, Marc D. Legault, Donald J. Pleshinger
Faculty Publications
The terrestrial gamma-ray flash (TGF) and Energetic Thunderstorm Rooftop Array (TETRA-II) detected 22 X-ray/gamma-ray flash events associated with lightning between October 2015 and March 2019 across three ground-based detector locations in subtropical and tropical climates in Louisiana, Puerto Rico, and Panama. Each detector array consists of a set of bismuth germanate scintillators that record X-ray and gamma-ray bursts over the energy range 50 keV–6 MeV (million electron volts). TETRA-II events have characteristics similar to both X-ray bursts associated with lightning leaders and TGFs: sub-millisecond duration, photons up to MeV energies, and association with nearby lightning (typically within 3 km). About …
Seed Treatment With Jasmonic Acid And Methyl Jasmonate Induces Resistance To Insects But Reduces Plant Growth And Yield In Rice, Oryza Sativa, Santhi Bhavanam, Michael Stout
Seed Treatment With Jasmonic Acid And Methyl Jasmonate Induces Resistance To Insects But Reduces Plant Growth And Yield In Rice, Oryza Sativa, Santhi Bhavanam, Michael Stout
Faculty Publications
When applied exogenously to plants, jasmonates [i.e., jasmonic acid (JA) and methyl jasmonate (MeJA)] increase plant resistance against herbivores, and their use in pest management has been suggested. For integration into pest management programs, the benefits of the resistance induced by jasmonates must outweigh the costs of jasmonates on plant growth and yield. A previous field study in rice found that seed treatment with MeJA reduced densities of the rice water weevil, Lissorhoptrus oryzophilus, but also reduced plant growth. Yields from MeJA plots were similar to yields from control plots. Because this study was conducted under field conditions with natural …
Extended Search For Supernovalike Neutrinos In Nova Coincident With Ligo/Virgo Detections, M. A. Acero, P. Adamson, L. Aliaga, N. Anfimov, A. Antoshkin, E. Arrieta-Diaz, L. Asquith, A. Aurisano, A. Back, C. Backhouse, M. Baird, N. Balashov, P. Baldi, B. A. Bambah, S. Bashar, K. Bays, R. Bernstein, V. Bhatnagar, B. Bhuyan, J. Bian, Roberto Petti, Et. Al.
Extended Search For Supernovalike Neutrinos In Nova Coincident With Ligo/Virgo Detections, M. A. Acero, P. Adamson, L. Aliaga, N. Anfimov, A. Antoshkin, E. Arrieta-Diaz, L. Asquith, A. Aurisano, A. Back, C. Backhouse, M. Baird, N. Balashov, P. Baldi, B. A. Bambah, S. Bashar, K. Bays, R. Bernstein, V. Bhatnagar, B. Bhuyan, J. Bian, Roberto Petti, Et. Al.
Faculty Publications
A search is performed for supernovalike neutrino interactions coincident with 76 gravitational wave events detected by the LIGO/Virgo Collaboration. For 40 of these events, full readout of the time around the gravitational wave is available from the NOvA Far Detector. For these events, we set limits on the fluence of the sum of all neutrino flavors of F < 7(4) × 1010 cm−2 at 90% C.L. assuming energy and time distributions corresponding to the Garching supernova models with masses 9.6ð27Þ M⊙. Under the hypothesis that any given gravitational wave event was caused by a supernova, this corresponds to a distance …
Auditing Non-Gaap Measures: Signaling More Than Intended, Spencer B. Anderson, Jessen L. Hobson, Ryan D. Sommerfeldt
Auditing Non-Gaap Measures: Signaling More Than Intended, Spencer B. Anderson, Jessen L. Hobson, Ryan D. Sommerfeldt
Faculty Publications
Many companies regularly disclose non-GAAP performance measures to communicate firm-specific information that does not fit within the mold of GAAP reporting. However, these non- GAAP measures may have low information content or even be misleading to investors. Thus, the question arises of whether auditors should play a larger role in the reporting of non-GAAP measures, which currently are not audited. We run an experiment to provide ex ante evidence on the effect of auditing non-GAAP measures. Specifically, we present investor-participants with a non- GAAP measure that should be used when making investment judgments (more informative) or should not be used …
Chagas Disease In Hiv-Infected Patients: It’S Time To Consider The Diagnosis, Melissa Nolan Ph.D., Mph, Natasha S. Hochberg
Chagas Disease In Hiv-Infected Patients: It’S Time To Consider The Diagnosis, Melissa Nolan Ph.D., Mph, Natasha S. Hochberg
Faculty Publications
No abstract provided.
Partial Charge Transfer And Absence Of Induced Magnetization In Eus(111)/Bi2se3 Heterostructures, Damien Tristant, Ilya Vekhter, Vincent Meunier, William A. Shelton
Partial Charge Transfer And Absence Of Induced Magnetization In Eus(111)/Bi2se3 Heterostructures, Damien Tristant, Ilya Vekhter, Vincent Meunier, William A. Shelton
Faculty Publications
Heterostructures made from topological and magnetic insulators promise to form excellent platforms for new electronic and spintronic functionalities mediated by interfacial effects. We report the results of a first-principles density functional theory study of the geometric, electronic structure, and magnetic properties of the EuS(111)/Bi2Se3 interface, including van der Waals and relativistic spin-orbit effects. In contrast to previous theoretical studies, we find no appreciable magnetic anisotropy in such a heterostructure. We also do not see additional induced magnetization at the interface or the magnetic proximity effect on the topological states. This is due to the localized nature of Eu moments and …
Effect Of An Antenatal Lifestyle Intervention On Dietary Inflammatory Index And Its Associations With Maternal And Fetal Outcomes: A Secondary Analysis Of The Pears Trial, Sarah Louise Killen, Catherine M. Phillips, Anna Delahunt, Cara A. Yelverton, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Maria A. Kennelly, Martina Cronin, John Mehegan, Fionnuala M. Mcauliffe
Effect Of An Antenatal Lifestyle Intervention On Dietary Inflammatory Index And Its Associations With Maternal And Fetal Outcomes: A Secondary Analysis Of The Pears Trial, Sarah Louise Killen, Catherine M. Phillips, Anna Delahunt, Cara A. Yelverton, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Maria A. Kennelly, Martina Cronin, John Mehegan, Fionnuala M. Mcauliffe
Faculty Publications
We investigated the effect of an antenatal lifestyle intervention of a low-glycaemic index (GI) diet and physical activity on energy-adjusted dietary inflammatory index (E-DIITM) and explored its relationship with maternal and child health in women with overweight and obesity. This was a secondary analysis of 434 mother−child pairs from the Pregnancy Exercise and Nutrition Study (PEARS) trial in Dublin, Ireland. E-DIITM scores were calculated for early (10–16 weeks) and late (28 weeks) pregnancy. Outcomes included lipids, inflammation markers, insulin resistance, mode of delivery, infant size, pre-eclampsia, and gestational diabetes. T-tests were used to assess changes in E-DIITM. …
Construction Industry Training Assessment Framework, Hazem Jadallah, Carol J. Friedland, Isabelina Nahmens, Charles Pecquet, Charles Berryman, Yimin Zhu
Construction Industry Training Assessment Framework, Hazem Jadallah, Carol J. Friedland, Isabelina Nahmens, Charles Pecquet, Charles Berryman, Yimin Zhu
Faculty Publications
The construction industry suffers from a lack of structured assessment methods to consistently gauge the efficacy of workforce training programs. To address this issue, this study presents a framework for construction industry training assessment that identifies established practices rooted in evaluation science and developed from a review of archival construction industry training literature. Inclusion criteria for the evaluated studies are: archival training studies focused on the construction industry workforce and integration of educational theory in training creation or implementation. Literature meeting these criteria are summarized and a case review is presented detailing assessment practices and results. The assessment practices are …
Daily Energy Expenditure Through The Human Life Course, Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. Camps, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B. Hoos, Sumei Hu, Noorjehan Joonas
Daily Energy Expenditure Through The Human Life Course, Herman Pontzer, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G. Camps, Graeme L. Close, Jamie A. Cooper, Richard Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B. Hoos, Sumei Hu, Noorjehan Joonas
Faculty Publications
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to …
Cocrfeni High-Entropy Alloy As An Enhanced Hydrogen Evolution Catalyst In An Acidic Solution, Frank Mckay, Yuxin Fang, Orhan Kizilkaya, Prashant Singh, Duane D. Johnson, Amitava Roy, David P. Young, Phillip T. Sprunger, John C. Flake, William A. Shelton, Ye Xu
Cocrfeni High-Entropy Alloy As An Enhanced Hydrogen Evolution Catalyst In An Acidic Solution, Frank Mckay, Yuxin Fang, Orhan Kizilkaya, Prashant Singh, Duane D. Johnson, Amitava Roy, David P. Young, Phillip T. Sprunger, John C. Flake, William A. Shelton, Ye Xu
Faculty Publications
High-entropy alloys (HEAs) have intriguing material properties, but their potential as catalysts has not been widely explored. Based on a concise theoretical model, we predict that the surface of a quaternary HEA of base metals, CoCrFeNi, should go from being nearly fully oxidized except for pure Ni sites when exposed to O2 to being partially oxidized in an acidic solution under cathodic bias, and that such a partially oxidized surface should be more active for the electrochemical hydrogen evolution reaction (HER) in acidic solutions than all the component metals. These predictions are confirmed by electrochemical and surface science experiments: the …
Independent Contributions Of Structural And Functional Connectivity: Evidence From A Stroke Model, Lynsey M. Keator, Grigori Yourganov, Alexandra Basilakos, Argye E. Hillis, Gregory Hickok, Leonardo Bonilha, Chris Rorden, Julius Fridriksson
Independent Contributions Of Structural And Functional Connectivity: Evidence From A Stroke Model, Lynsey M. Keator, Grigori Yourganov, Alexandra Basilakos, Argye E. Hillis, Gregory Hickok, Leonardo Bonilha, Chris Rorden, Julius Fridriksson
Faculty Publications
Altered functional connectivity is related to severity of language impairment in poststroke aphasia. However, it is not clear whether this finding specifically reflects loss of functional coherence, or more generally, is related to decreased structural connectivity due to cortical necrosis. The aim of the current study was to investigate this issue by factoring out structural connectivity from functional connectivity measures and then relating the residual data to language performance poststroke. Ninety-seven participants with a history of stroke were assessed using language impairment measures (Auditory Verbal Comprehension and Spontaneous Speech scores from the Western Aphasia Battery-Revised) and MRI (structural, diffusion tensor …
Adaptation Of The Agency For Healthcare Research And Quality’S ‘Hospital Survey On Patient Safety Culture’ To The Bosnia And Herzegovina Context, Šehad Draganović, Guido Offermanns, Rachel E. Davis
Adaptation Of The Agency For Healthcare Research And Quality’S ‘Hospital Survey On Patient Safety Culture’ To The Bosnia And Herzegovina Context, Šehad Draganović, Guido Offermanns, Rachel E. Davis
Faculty Publications
OBJECTIVES: Measuring staff perspectives on patient safety culture (PSC) can identify areas of concern that, if addressed, could lead to improvements in healthcare. To date, there is no validated measure to assess PSC that has been tested and adapted for use in Bosnia and Herzegovina (BiH). This research addresses the gap in the evidence through the psychometric assessment of the Agency for Healthcare Research and Quality's: 'Hospital Survey on Patient Safety Culture' (HSOPSC), to determine its suitability for the health system in BiH. SETTING: Nine hospitals. PARTICIPANTS: Healthcare professionals (n=1429); nurse (n=823), doctors (n=328), other clinical personnel (n=111), non-clinical personnel …
Racism As Public Health Crisis: Assessment And Review Of Municipal Declarations And Resolutions Across The United States, Dara D. Mendez, Jewel Scott Phd, Rn, Fnp-C, Linda Adodoadji, Christina Toval, Monica Mcneil, Mahima Sindhu
Racism As Public Health Crisis: Assessment And Review Of Municipal Declarations And Resolutions Across The United States, Dara D. Mendez, Jewel Scott Phd, Rn, Fnp-C, Linda Adodoadji, Christina Toval, Monica Mcneil, Mahima Sindhu
Faculty Publications
Racism in the United States has been cited as a key driver of racial health inequities. Racism as a public health crisis has been in the forefront, particularly with respect to state and municipal governments that have developed legislation, resolutions, and declarations. This policy brief includes a review of resolutions and declarations across the US related to Racism as a Public Health Crisis through the end of September 2020. There were 125 resolutions reviewed for content related to the history of racism, reference to racial health equity data, content related to action steps or implementation, and any accompanying funding or …
Graphdti: A Robust Deep Learning Predictor Of Drug-Target Interactions From Multiple Heterogeneous Data, G N. Liu, M Singha, L M. Pu, P Neupane, G N. Liu, H C. Wu, J Ramanujam, M Brylinski
Graphdti: A Robust Deep Learning Predictor Of Drug-Target Interactions From Multiple Heterogeneous Data, G N. Liu, M Singha, L M. Pu, P Neupane, G N. Liu, H C. Wu, J Ramanujam, M Brylinski
Faculty Publications
Traditional techniqueset identification, we developed GraphDTI, a robust machine learning framework integrating the molecular-level information on drugs, proteins, and binding sites with the system-level information on gene expression and protein-protein interactions. In order to properly evaluate the performance of GraphDTI, we compiled a high-quality benchmarking dataset and devised a new cluster-based cross-validation p to identify macromolecular targets for drugs utilize solely the information on a query drug and a putative target. Nonetheless, the mechanisms of action of many drugs depend not only on their binding affinity toward a single protein, but also on the signal transduction through cascades of molecular …
Analysis Of The Effects Of Spatiotemporal Demand Data Aggregation Methods On Distance And Volume Errors, Zachary Hornberger, Bruce A. Cox, Raymond R. Hill
Analysis Of The Effects Of Spatiotemporal Demand Data Aggregation Methods On Distance And Volume Errors, Zachary Hornberger, Bruce A. Cox, Raymond R. Hill
Faculty Publications
Purpose — Large/stochastic spatiotemporal demand data sets can prove intractable for location optimization problems, motivating the need for aggregation. However, demand aggregation induces errors. Significant theoretical research has been performed related to the modifiable areal unit problem and the zone definition problem. Minimal research has been accomplished related to the specific issues inherent to spatiotemporal demand data, such as search and rescue (SAR) data. This study provides a quantitative comparison of various aggregation methodologies and their relation to distance and volume based aggregation errors. Design/methodology/approach — This paper introduces and applies a framework for comparing both deterministic and stochastic aggregation …
Augmenting The Space Domain Awareness Ground Architecture Via Decision Analysis And Multi-Objective Optimization, Albert R. Vasso, Richard G. Cobb, John M. Colombi, Bryan D. Little, David R. Meyer
Augmenting The Space Domain Awareness Ground Architecture Via Decision Analysis And Multi-Objective Optimization, Albert R. Vasso, Richard G. Cobb, John M. Colombi, Bryan D. Little, David R. Meyer
Faculty Publications
Purpose — The US Government is challenged to maintain pace as the world’s de facto provider of space object cataloging data. Augmenting capabilities with nontraditional sensors present an expeditious and low-cost improvement. However, the large tradespace and unexplored system of systems performance requirements pose a challenge to successful capitalization. This paper aims to better define and assess the utility of augmentation via a multi-disiplinary study. Design/methodology/approach — Hypothetical telescope architectures are modeled and simulated on two separate days, then evaluated against performance measures and constraints using multi-objective optimization in a heuristic algorithm. Decision analysis and Pareto optimality identifies a set …
Racism As Public Health Crisis: Assessment And Review Of Municipal Declarations And Resolutions Across The United States, Dara D. Mendez, Jewel Scott Phd, Rn, Fnp-C, Linda Adodoadji, Christina Toval, Monica Mcneil, Mahima Sindhu
Racism As Public Health Crisis: Assessment And Review Of Municipal Declarations And Resolutions Across The United States, Dara D. Mendez, Jewel Scott Phd, Rn, Fnp-C, Linda Adodoadji, Christina Toval, Monica Mcneil, Mahima Sindhu
Faculty Publications
Racism in the United States has been cited as a key driver of racial health inequities. Racism as a public health crisis has been in the forefront, particularly with respect to state and municipal governments that have developed legislation, resolutions, and declarations. This policy brief includes a review of resolutions and declarations across the US related to Racism as a Public Health Crisis through the end of September 2020. There were 125 resolutions reviewed for content related to the history of racism, reference to racial health equity data, content related to action steps or implementation, and any accompanying funding or …
Normalization Of Muscle Strength Measurements In The Assessment Of Cardiometabolic Risk Factors In Adolescents, Tiago Rodrigues De Lima, Xuemei Sui M.D., M.P.H., Ph.D., Diego Augusto Santos Silva
Normalization Of Muscle Strength Measurements In The Assessment Of Cardiometabolic Risk Factors In Adolescents, Tiago Rodrigues De Lima, Xuemei Sui M.D., M.P.H., Ph.D., Diego Augusto Santos Silva
Faculty Publications
Muscle strength (MS) has been associated with cardiometabolic risk factors (CMR) in adolescents, however, the impact attributed to body size in determining muscle strength or whether body size acts as a confounder in this relationship remains controversial. We investigated the association between absolute MS and MS normalized for body size with CMR in adolescents. This was a cross-sectional study comprising 351 adolescents (44.4% male; 16.6 ± 1.0 years) from Brazil. MS was assessed by handgrip and normalized for body weight, body mass index (BMI), height, and fat mass. CMR included obesity, high blood pressure, dyslipidemia, glucose imbalance, and high inflammation …
Water Insecurity Is Associated With Lack Of Viral Suppression And Greater Odds Of Aids-Defining Illnesses Among Adults With Hiv In Western Kenya, Jason M. Nagata, Joshua D. Miller, Craig R. Cohen, Edward A. Frongillo Jr., Elly Weke, Rachel Burger, Pauline Wekesa, Lila A. Sheira, A Rain Mocello, Phelgona Otieno, Lisa M. Butler, Elizabeth A. Bukusi, Sheri D. Weiser, Sera L. Young
Water Insecurity Is Associated With Lack Of Viral Suppression And Greater Odds Of Aids-Defining Illnesses Among Adults With Hiv In Western Kenya, Jason M. Nagata, Joshua D. Miller, Craig R. Cohen, Edward A. Frongillo Jr., Elly Weke, Rachel Burger, Pauline Wekesa, Lila A. Sheira, A Rain Mocello, Phelgona Otieno, Lisa M. Butler, Elizabeth A. Bukusi, Sheri D. Weiser, Sera L. Young
Faculty Publications
Reliable access to safe and acceptable water in sufficient quantities (i.e., water security) is important for medication adherence and limiting pathogen exposure, yet prior studies have only considered the role of food security as a social determinant of HIV-related health. Therefore, the objective of this analysis was to assess the relationships between household water insecurity and HIV-related outcomes among adults living with HIV in western Kenya (N = 716). We conducted a cross-sectional analysis of baseline data from Shamba Maisha (NCT02815579), a cluster randomized controlled trial of a multisectoral agricultural and asset loan intervention. Baseline data were collected from June …