Digital Commons Network^™

Quality Of Farmed Shrimp (Penaeus Monodon, Fabricius, 1798 And Macrobrachium Rosenbergii, Deman, 1879) As Affected By Melanosis Inhibiting Compounds, M. Khan, J. A. Lively

Faculty Publications

A problem associated with shrimp is blackspot or melanosis and to prevent blackspot, sulfites have been used for years but come with additional health risks. Newer 4-hexylresorcinol formulations exist that allow sulfite-free shrimp, but effects on the quality of Penaeus monodon Fabricius, 1798, and Macrobrachium rosenbergii, de Man, 1879, beyond melanosis prevention are unknown. Adverse effects on the quality of the shrimp from melanosis prevention treatments would negatively offset the benefits of a sulfite-free product. In order to determine if prevention compounds (sulfite powder or 4-hexylresorcinol based compounds, Everfresh® and Xyrex® Prawnfresh™) affect quality, proximate composition and total plate count …

When Can Local Bird Detection Radars Best Complement Broad-Scale Early-Warning Forecasts Of Risk Potential For Bird–Aircraft Strikes As Part Of An Integrated Approach To Strike Mitigation?, Melanie R. Colón, Ashley M. Long

Faculty Publications

Worldwide, wildlife–aircraft strikes cost more than US$1.2 billion in aircraft damage and downtime and jeopardize the safety of aircrews, passengers, and animals. Radar has long been used to monitor flying animal movements and can be a useful tool for strike mitigation. In the USA, the Avian Hazard Advisory System (AHAS) is an early-warning system that integrates data from next-generation weather radar (NEXRAD) weather surveillance radars (WSRs) with historic bird occurrence data to quantify avian activity and forecast the relative bird risk within a ~9.3-km radius of military and civilian airfields. Bird detection radars (BDRs) with both horizontal-surveillance and vertical-scanning components …

A High-Quality De Novo Genome Assembly For Clapper Rail (Rallus Crepitans), Elisa C. Elizondo, Brant C. Faircloth, Robb T. Brumfield, Subir B. Shakya, Vincenzo A. Ellis, Carl J. Schmidt, Adrienne I. Kovach, W. Gregory Shriver

Faculty Publications

The clapper rail (Rallus crepitans), of the family Rallidae, is a secretive marsh bird species that is adapted for high salinity habitats. They are very similar in appearance to the closely related king rail (R. elegans), but while king rails are limited primarily to freshwater marshes, clapper rails are highly adapted to tolerate salt marshes. Both species can be found in brackish marshes where they freely hybridize, but the distribution of their respective habitats precludes the formation of a continuous hybrid zone and secondary contact can occur repeatedly. This system, thus, provides unique opportunities to investigate the underlying mechanisms driving …

Science Diplomacy From The Global South: The Case Of Intergovernmental Science Organizations, Anna Lena Rüland, Nicolas Rüffin, Katharina Cramer, Prosper Ngabonziza, Manoj Saxena, Stefan Skupien

Faculty Publications

Intergovernmental science organizations (IGSOs) address many challenges of the 21st century. Several countries of the Global South have joined established IGSOs or have created new ones. Yet we know little about their interests in IGSOs. Our study addresses this blind spot by investigating which objectives Southern actors pursue in IGSOs and under which conditions they are likely to achieve their objectives. Using insights from three strands of literature, we compare four IGSOs with Southern participation: the European Organization for Nuclear Research, the International Thermonuclear Experimental Reactor, the Square Kilometer Array, and the African Lightsource. We show that countries of the …

The Master Growth Regulator Della Binding To Histone H2a Is Essential For Della-Mediated Global Transcription Regulation, Xu Huang, Hao Tian, Jeongmoo Park, Dong Ha Oh, Jianhong Hu, Rodolfo Zentella, Hong Qiao, Maheshi Dassanayake, Tai Ping Sun

Faculty Publications

The DELLA genes, also known as ‘Green Revolution’ genes, encode conserved master growth regulators that control plant development in response to internal and environmental cues. Functioning as nuclear-localized transcription regulators, DELLAs modulate expression of target genes via direct protein–protein interaction of their carboxy-terminal GRAS domain with hundreds of transcription factors (TFs) and epigenetic regulators. However, the molecular mechanism of DELLA-mediated transcription reprogramming remains unclear. Here by characterizing new missense alleles of an Arabidopsis DELLA, repressor of ga1-3 (RGA), and co-immunoprecipitation assays, we show that RGA binds histone H2A via the PFYRE subdomain within its GRAS domain to form a TF–RGA–H2A …

Chemical Characterization And Impact Of Nipple Fruit (Solanum Mammosum) On The Characteristics Of Lactobacillus Acidophilus La K, Ricardo S. Aleman, Dany Avila, Allan Avila, Jack N. Losso, David Picha, Zhimin Xu, Kayanush Aryana

Faculty Publications

Nipple fruit (Solanum mammosum) has been considered to have great pharmaceutical potential because of its high amounts of solamargine and solasonine. This study aimed to examine the effect of nipple fruit at different concentrations (0.5%, 1%, and 2% (w/v)) on the viability, acid, bile, lysozyme, and gastric juice tolerance, and protease activity of Lactobacillus acidophilus LA K. The viability was studied in MRS broth. Acid tolerance was determined by adjusting the pH to 2, whereas bile tolerance was examined with oxgall 0.3% (w/v) in MRS broth. Lysozyme resistance was investigated in an electrolyte solution with lysozyme (100 mg/L), while gastric …

Unlocking The Potential Of Kinase Targets In Cancer: Insights From Canceromicsnet, An Ai-Driven Approach To Drug Response Prediction In Cancer, Manali Singha, Limeng Pu, Gopal Srivastava, Xialong Ni, Brent A. Stanfield, Ifeanyi K. Uche, Paul J.F. Rider, Konstantin G. Kousoulas, J. Ramanujam, Michal Brylinski

Faculty Publications

Deregulated protein kinases are crucial in promoting cancer cell proliferation and driving malignant cell signaling. Although these kinases are essential targets for cancer therapy due to their involvement in cell development and proliferation, only a small part of the human kinome has been targeted by drugs. A comprehensive scoring system is needed to evaluate and prioritize clinically relevant kinases. We recently developed CancerOmicsNet, an artificial intelligence model employing graph-based algorithms to predict the cancer cell response to treatment with kinase inhibitors. The performance of this approach has been evaluated in large-scale benchmarking calculations, followed by the experimental validation of selected …

The Water Mills Of The Historic Río Arriba In Northcentral New Mexico, 1598-1975, José A. Rivera Ph.D, Thomas F. Glick Ph.D

Faculty Publications

The water mills of New Mexico played a major role in the agricultural economy of the Río Arriba for centuries following the introduction of wheat from the Old World to the Americas. Wheat, in its ground form as flour, was a staple during the Spanish colonial period. To process raw wheat, local grist mills (molinos) were essential infrastructure as were the aceq uias (ditches) that powered them. Situated near the banks of rivers, the internal components of each mill were driven by the gravity force of water from an acequia, itself diverted from the river. Researchers have documented …

Complexity Heliophysics: A [New] System Science That Transcends The Previous Boundaries Of Our Field, Ryan M. Mcgranaghan, Seebany Datta-Barua, Jeffrey Thayer, Joe Borovsky, Jay R. Johnson, Simon Wing, Dan Baker, Massimo Materassi

Faculty Publications

Synopsis

1. The 21st century is the time of complexity. We delineate it and its importance as necessary to solve ‘wicked problems.’

2. Inherently transdisciplinary, trans-scale, and interconnected to living systems, the solution to Heliophysics’ identity crisis and to unlock the next generation of scientific discovery may be to embrace complexity.

3. With the right foresight, direction, and incentive over the next ten years, Heliophysics can become a beacon for how all of society thinks about and does complexity science.

The Emergence Of Convergence, Shana M. Sundstrom, David G. Angeler, Jessica G. Ernakovich, Jorge H. Garcia, Joseph A. Hamm, Orville Huntington, Craig R. Allen

Faculty Publications

Science is increasingly a collaborative pursuit. Although the modern scientific enterprise owes much to individuals working at the core of their field, humanity is increasingly confronted by highly complex problems that require the integration of a variety of disciplinary and methodological expertise. In 2016, the U.S. National Science Foundation launched an initiative prioritizing support for convergence research as a means of “solving vexing research problems, in particular, complex problems focusing on societal needs.” We discuss our understanding of the objectives of convergence research and describe in detail the conditions and processes likely to generate successful convergence research. We use our …

Modulating Water Distribution And The Intramicellar Assembly Of Sequence-Defined Ionic Peptoid Block Copolymers By The Ionic Monomer Position, Bailee N. Barrett, Chi Huan Tung, Guan Rong Huang, Istiak Hossain, Chang Woo Do, Vijay T. John, Wei Ren Chen, Donghui Zhang

Faculty Publications

The intramicellar mass heterogeneity of a series of sequence-defined ionic peptoid block copolymers carrying a single charged monomer has been determined through contrast variation small-angle neutron scattering analysis. We observe that the internal micellar structure, namely, the number density radial distributions of invasive water and peptoid polymer, is significantly impacted by the location of the ionic monomer. By positioning the ionic monomer progressively closer to the hydrophilic/hydrophobic block junction, the micelles become less compact with increasing levels of chain folding and invasive water to accommodate electrostatic repulsion among the ionic monomers via solvation. This results in increasingly smaller micellar aggregates …

Liposomes For The Treatment Of Brain Cancer—A Review, Richu Raju, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain barrier (BBB). Additionally, strategies have been explored to synthesize liposomes that respond to internal and/or external stimuli to release their payload controllably. Although research into liposomes for brain cancer treatment is still in its infancy, these systems have great potential to fundamentally change the drug delivery landscape. This review paper attempts to consolidate relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes. The paper first briefly explains conventional treatment modalities for cancer, followed …

A Review On Membrane Fouling Prediction Using Artificial Neural Networks (Anns), Waad H. Abuwatfa, Nour Al Sawaftah, Naif Darwish, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Membrane fouling is a major hurdle to effective pressure-driven membrane processes, such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO). Fouling refers to the accumulation of particles, organic and inorganic matter, and microbial cells on the membrane’s external and internal surface, which reduces the permeate flux and increases the needed transmembrane pressure. Various factors affect membrane fouling, including feed water quality, membrane characteristics, operating conditions, and cleaning protocols. Several models have been developed to predict membrane fouling in pressure-driven processes. These models can be divided into traditional empirical, mechanistic, and artificial intelligence (AI)-based models. Artificial neural networks …

Gender (In)Equity In Global Mental Health Research: A Call To Action, The Women In Global Mental Health Research Group, Kelly Rose-Clarke

Faculty Publications

In this commentary, we build on work by Gurung and colleagues which highlighted gender inequity in the global mental health research workforce in Nepal (Gurung et al., 2021). We seek to increase awareness of the under-representation of women in global mental health research and its consequences, and we call for change. By women, we refer to all people who identify as women, including trans people. The commentary is informed by conversations with women who are global mental health researchers in the Global North and South at various stages of their careers.

Short-Term Responses Of Soil Carbon, Nitrogen, And Microbial Biomass To Cover Crop Mixtures And Monocultures, Igor Alexandre De Souza, Amanda B. Daly, Jorg Schnecker, Nicholas D. Warren, Adalfredo Rocha Lobo Jr., Richard G. Smith, Andre Fonseca Brito, A. Stuart Grandy

Faculty Publications

Increasingly, cover crops are being adopted for the purpose of improving soil health, yet the timescale and magnitude by which living annual cover crops might modify soil chemical and biological aspects of soil health is not well understood. At the same time, there is growing interest among farmers in cover crop mixtures due to perceptions that species-rich cover crop communities will enhance soil health relative to monocultures. In a field experiment in southeast New Hampshire, we investigated how groups of cover crops grown as monocultures and mixtures for specific seasonal niches (winter/spring, summer, and fall) influenced levels of soil nitrogen …

Year-Round Weather Alters Nest-Provisioning Rates In A Migratory Owl, Eliza D. Stein, Stephen R. Midway, Brian D. Linkhart

Faculty Publications

As global temperatures and precipitation become more extreme, habitat specialists are at particular risk of being pushed past their environmental tolerance limits. Flammulated Owls (Psiloscops flammeolus) are small migratory owls that breed in temperate conifer forests of western North America. Their highly specialized nesting and foraging requirements make them indicators of ecosystem health. Using 17 years of nest observations, we investigated how annual weather patterns affected Flammulated Owl nesting and foraging behaviors during the breeding season. We used generalized linear models with a changepoint parameter to evaluate nest provisioning and nestling growth rates in years of extreme temperature and precipitation. …

Evidence For Two Soybean Looper Strains In The United States With Limited Capacity For Cross-Hybridization, Rodney N. Nagoshi, Jeffrey A. Davis, Robert L. Meagher, Fred R. Musser, Graham P. Head, Hector Portillo, Henry Teran

Faculty Publications

The noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker) is an economically important pest of soybeans (Glycine max (L.) Merr.) in the southeastern United States. It has characteristics that are of particular concern for pest mitigation that include a broad host range, the capacity for annual long-distance flight, and resistance in some populations to important pesticides such as pyrethroids and chitin synthesis inhibitor. The biology of SBL in the United States resembles that of the fellow noctuid fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), a major pest of corn and several other crops. FAW exhibits a population structure in that …

Investigating The Migratory Behavior Of Soybean Looper, A Major Pest Of Soybean, Through Comparisons With The Corn Pest Fall Armyworm Using Mitochondrial Haplotypes And A Sex-Linked Marker, Rodney N. Nagoshi, Jeffrey A. Davis, Robert L. Meagher, Fred R. Musser, Graham P. Head, Hector Portillo, Henry Teran

Faculty Publications

The Noctuid moth soybean looper (SBL), Chrysodeixis includens (Walker), is an economically important pest of soybean (Glycine max (Linnaeus) Merrill). Because it is not known to survive freezing winters, permanent populations in the United States are believed to be limited to the southern regions of Texas and Florida, yet its geographical range of infestations annually extend to Canada. This indicates annual migrations of thousands of kilometers during the spring and summer growing season. This behavior is like that of the fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), also a Noctuid that is a major global pest of corn. SBL and …

Clathrin-Mediated Endocytosis Facilitates The Internalization Of Magnaporthe Oryzae Effectors Into Rice Cells, Ely Oliveira-Garcia, Tej Man Tamang, Jungeun Park, Melinda Dalby, Magdalena Martin-Urdiroz, Clara Rodriguez Herrero, An Hong Vu, Sunghun Park, Nicholas J. Talbot, Barbara Valent

Faculty Publications

Fungi and oomycetes deliver effectors into living plant cells to suppress defenses and control plant processes needed for infection. Little is known about the mechanism by which these pathogens translocate effector proteins across the plasma membrane into the plant cytoplasm. The blast fungus Magnaporthe oryzae secretes cytoplasmic effectors into a specialized biotrophic interfacial complex (BIC) before translocation. Here, we show that cytoplasmic effectors within BICs are packaged into punctate membranous effector compartments that are occasionally observed in the host cytoplasm. Live cell imaging with fluorescently labeled proteins in rice (Oryza sativa) showed that these effector puncta colocalize with the plant …

A Cyclical Phenomenon Among Stock & Commodity Markets, Hector O. Zapata, Junior E. Betanco, Maria Bampasidou, Michael Deliberto

Faculty Publications

Considerable studies have examined the relationship between commodity markets and stock markets. This paper studies the cyclical relationship between commodity markets and stock markets with implications for investing based on index relationships. Stock markets are represented by the U.S. S&P 500 index and aggregate commodity markets by the U.S. producer price index (PPI). Tradeable market indexes readily available to investors, namely the S&P GSCI Index and the Bloomberg Commodity Index (BCOM), are also studied. An optimal bandpass filter is used to estimate the cyclical component using a pricing-performance measure of the S&P 500 relative to the PPI, based on annual …

Extended Sentinel Monitoring Of Helicoverpa Zea Resistance To Cry And Vip3aa Toxins In Bt Sweet Corn: Assessing Changes In Phenotypic And Allele Frequencies Of Resistance, Galen P. Dively, Tom P. Kuhar, Sally V. Taylor, Helene Doughty, Kristian Holmstrom, Daniel O. Gilrein, Brian A. Nault, Joseph Ingerson-Mahar, Anders Huseth, Dominic Reisig, Shelby Fleischer, David Owens, Kelley Tilmon, Francis Reay-Jones, Pat Porter, Jocelyn Smith, Julien Saguez, Jason Wells, Caitlin Congdon, Holly Byker, Bryan Jensen, Chris Difonzo, William D. Hutchison, Eric Burkness, Robert Wright, Michael Crossley, Heather Darby, Tom Bilbo, Nicholas Seiter, Christian Krupke, Craig Abel, Brad S. Coates, Bradley Mcmanus

Faculty Publications

Transgenic corn and cotton that produce Cry and Vip3Aa toxins derived from Bacillus thuringiensis (Bt) are widely planted in the United States to control lepidopteran pests. The sustainability of these Bt crops is threatened because the corn earworm/bollworm, Helicoverpa zea (Boddie), is evolving a resistance to these toxins. Using Bt sweet corn as a sentinel plant to monitor the evolution of resistance, collaborators established 146 trials in twenty-five states and five Canadian provinces during 2020–2022. The study evaluated overall changes in the phenotypic frequency of resistance (the ratio of larval densities in Bt ears relative to densities in non-Bt ears) …

Large Uncertainties In Co2 Water–Air Outgassing Estimation With Gas Exchange Coefficient Kt For A Large Lowland River, Anamika Dristi, Y. Jun Xu

Faculty Publications

Aquatic CO2 emission is typically estimated (i.e., not measured) through a gas exchange balance. Several factors can affect the estimation, primarily flow velocity and wind speed, which can influence a key parameter, the gas exchange coefficient KT in the balancing approach. However, our knowledge of the uncertainty of predictions using these factors is rather limited. In this study, we conducted a numeric assessment on the impact of river flow velocity and wind speed on KT and the consequent CO2 emission rate. As a case study, we utilized 3-year (2019–2021) measurements on the partial pressure of dissolved carbon dioxide (pCO2) in …

Substantially Enhanced Landscape Carbon Sink Due To Reduced Terrestrial-Aquatic Carbon Transfer Through Soil Conservation In The Chinese Loess Plateau, Lishan Ran, Nufang Fang, Xuhui Wang, Shilong Piao, Chun Ngai Chan, Siliang Li, Yi Zeng, Zhihua Shi, Mingyang Tian, Yi Jun Xu, Junyu Qi, Boyi Liu

Faculty Publications

Soil conservation is of global importance, as accelerated soil erosion by human activity is a primary threat to ecosystem viability. However, the significance and role of soil conservation in reshaping landscape carbon (C) accounting has not been comprehensively integrated in the terrestrial C sink. Here, we present the first integrated assessment of the modified terrestrial C sink and aquatic C transport due to soil conservation for the semiarid Chinese Loess Plateau (CLP), the world's most vulnerable region to soil erosion. We show a surprisingly low terrestrial-aquatic C transfer that offset the terrestrial net ecosystem productivity by only 7.5%, which we …

A Modified-Herringbone Micromixer For Assessing Zebrafish Sperm (Mags), Jorge A. Belgodere, Mustafa Alam, Valentino E. Browning, Jason Eades, Jack North, Julie A. Armand, Yue Liu, Terrence R. Tiersch, W. Todd Monroe

Faculty Publications

Sperm motility analysis of aquatic model species is important yet challenging due to the small sample volume, the necessity to activate with water, and the short duration of motility. To achieve standardization of sperm activation, microfluidic mixers have shown improved reproducibility over activation by hand, but challenges remain in optimizing and simplifying the use of these microdevices for greater adoption. The device described herein incorporates a novel micromixer geometry that aligns two sperm inlet streams with modified herringbone structures that split and recombine the sample at a 1:6 dilution with water to achieve rapid and consistent initiation of motility. The …

Long-Term Capture Data Uncover Shifts In The Daily Activity Patterns Of Amazonian Birds, Cameron L. Rutt, Philip C. Stouffer, Bruna R. Amaral, David A. Luther

Faculty Publications

Although the duration of biological rhythms varies from milliseconds to decades, daily cycles are especially widespread for individual organisms. These circadian rhythms are synchronized by light–dark cycles, which govern predictable changes in other microclimate variables. Despite the fixed, regular nature of these abiotic cycles at low latitudes, little is known about how different animals structure activity along these gradients. We used 25 years of capture–recapture data and ~ 25 000 unique captures to characterize ‘activity' (time of capture) for 65 species of Amazonian birds in the lowest forest stratum (0–2.5 m). To quantify vertical niche breadths, we also measured foraging …

Extensive Independent Amplification Of Platy-1 Retroposons In Tamarins, Genus Saguinus, Jessica M. Storer, Jerilyn A. Walker, Thomas O. Beckstrom, Mark A. Batzer

Faculty Publications

Platy-1 retroposons are short interspersed elements (SINEs) unique to platyrrhine primates. Discovered in the common marmoset (Callithrix jacchus) genome in 2016, these 100 bp mobile element insertions (MEIs) appeared to be novel drivers of platyrrhine evolution, with over 2200 full-length members across 62 different subfamilies, and strong evidence of ongoing proliferation in C. jacchus. Subsequent characterization of Platy-1 elements in Aotus, Saimiri and Cebus genera, suggested that the widespread mobilization detected in marmoset (family Callithrichidae) was perhaps an anomaly. Two additional Callithrichidae genomes are now available, a scaffold level genome assembly for Saguinus imperator (tamarin; SagImp_v1) and a chromosome-level assembly …

Vcp Promotes Ttaf-Target Gene Expression And Spermatocyte Differentiation By Downregulating Mono-Ubiquitylated H2a, Tyler J. Butsch, Olga Dubuisson, Alyssa E. Johnson, K. Adam Bohnert

Faculty Publications

Valosin-containing protein (VCP) binds and extracts ubiquitylated cargo to regulate protein homeostasis. VCP has been studied primarily in aging and disease contexts, but it also affects germline development. However, the precise molecular functions of VCP in the germline, particularly in males, are poorly understood. Using the Drosophila male germline as a model system, we find that VCP translocates from the cytosol to the nucleus as germ cells transition into the meiotic spermatocyte stage. Importantly, nuclear translocation of VCP appears to be one crucial event stimulated by testis-specific TBP-associated factors (tTAFs) to drive spermatocyte differentiation. VCP promotes the expression of several …

Gene Editing Provides A Tool To Investigate Genes Involved In Reproduction Of Pigs, Rodney D. Geisert, Destiny N. Johns, Caroline A. Pfeiffer, Riley M. Sullivan, Caroline G. Lucas, Constantine A. Simintiras, Bethany K. Redel, Kevin D. Wells, Thomas E. Spencer, Randall S. Prather

Faculty Publications

CRISPR-Cas9 gene editing technology provides a method to generate loss-of-function studies to investigate, in vivo, the specific role of specific genes in regulation of reproduction. With proper design and selection of guide RNAs (gRNA) designed to specifically target genes, CRISPR-Cas9 gene editing allows investigation of factors proposed to regulate biological pathways involved with establishment and maintenance of pregnancy. The advantages and disadvantages of using the current gene editing technology in a large farm species is discussed. CRISPR-Cas9 gene editing of porcine conceptuses has generated new perspectives for the regulation of endometrial function during the establishment of pregnancy. The delicate orchestration …

Medical Libraries And Their Complicated Past: An Exploration Of The Historical Connections Between Medical Collections And Racial Science, Raymond Pun, Patrice R. Green, Nicollette Davis

Faculty Publications

For over a millennium, libraries and library workers have advanced the knowledge of human science by building, preserving, and sharing collections and research. Historically, libraries have also aligned their institutional responsibilities to adhere to and support the values and virtues of oppressive and colonial practices. Library history has shown the mistreatments and denials of information access of marginalized groups. The history of libraries in the health and medical sciences reveals how these institutions and their workers have preserved and circulated research studies perpetuating racial science. This commentary highlights how such institutions shape and contribute to racial science in the field …

Effects Of Alkylation On Potency Of Benz[A]Anthracene For Ahr2 Transactivation In Nine Species Of Freshwater Fish, Justin Dubiel, Hunter Johnson, Andreas N.M. Eriksson, A. Hontela, Jon A. Doering, Steve Wiseman

Faculty Publications

Polycyclic aromatic hydrocarbons (PAHs) are naturally occurring or anthropogenic organic chemicals that can activate the aryl hydrocarbon receptor 2 (AhR2) and induce toxicity in fishes. Alkyl PAHs are more abundant than nonalkylated PAHs in certain environmental matrices and there is growing evidence that alkylation can increase potency, dependent on the position of alkylation. However, it is unknown if the effect of alkylation on potency is conserved across species. In addition, relatively little is known regarding the extent of interspecies variation in sensitivity to PAHs and alkyl PAHs. Therefore, objectives of the present study were to characterize potency of benz[a]anthracene (BAA) …