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Adiponectin Reduces Bone Stiffness: Verified In A Three-Dimensional Artificial Human Bone Model In Vitro, Sigrid Haugen, Jianying He, Alamelu Sundaresan, Astrid Kamilla Stunes, Kristin Matre Aasarød, Hanna Tiainen, Unni Syversen, Bjørn Skallerud, Janne Elin Reseland May 2018

Adiponectin Reduces Bone Stiffness: Verified In A Three-Dimensional Artificial Human Bone Model In Vitro, Sigrid Haugen, Jianying He, Alamelu Sundaresan, Astrid Kamilla Stunes, Kristin Matre Aasarød, Hanna Tiainen, Unni Syversen, Bjørn Skallerud, Janne Elin Reseland

Faculty Publications

Primary human osteoblasts and osteoclasts incubated in a rotating coculture system without any scaffolding material, form bone-like tissue that may be used to evaluate effects of various compounds on mechanical strength. Circulating adiponectin has been found to be negatively associated with BMD and strength and was therefore assessed in this system. Osteospheres of human osteoblasts and osteoclasts were generated with and without adiponectin. The osteospheres were scanned using micro-computed tomography, the mechanical properties were tested by flat punch compression using nanoindentation equipment, and the cellular morphology characterized by microscopy. The association between autologously produced adiponectin and biomechanical properties was further …

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Direct Determination Of Hydroxymethyl Conformations Of Plant Cell Wall Cellulose Using 1 H Polarization Transfer Solid-State Nmr, Pyae Phyo, Tuo Wang, Yu Yang, Hugh O'Neill, Mei Hong May 2018

Direct Determination Of Hydroxymethyl Conformations Of Plant Cell Wall Cellulose Using 1 H Polarization Transfer Solid-State Nmr, Pyae Phyo, Tuo Wang, Yu Yang, Hugh O'Neill, Mei Hong

Faculty Publications

Copyright © 2018 American Chemical Society. In contrast to the well-studied crystalline cellulose of microbial and animal origins, cellulose in plant cell walls is disordered due to its interactions with matrix polysaccharides. Plant cell wall (PCW) is an undisputed source of sustainable global energy; therefore, it is important to determine the molecular structure of PCW cellulose. The most reactive component of cellulose is the exocyclic hydroxymethyl group: when it adopts the tg conformation, it stabilizes intrachain and interchain hydrogen bonding, while gt and gg conformations destabilize the hydrogen-bonding network. So far, information about the hydroxymethyl conformation in cellulose has been …

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Baseline Effects Of Lysophosphatidylcholine And Nerve Growth Factor In A Rat Model Of Sciatic Nerve Regeneration After Crush Injury, Ryan L. Wood, Keaton S. Karlinsey, Austin D. Thompson, Mark N. Rigby, Greggory D. Boatright, William G. Pitt, Beverly L. Roeder, Scott C. Steffersen, Alonzo D. Cook May 2018

Baseline Effects Of Lysophosphatidylcholine And Nerve Growth Factor In A Rat Model Of Sciatic Nerve Regeneration After Crush Injury, Ryan L. Wood, Keaton S. Karlinsey, Austin D. Thompson, Mark N. Rigby, Greggory D. Boatright, William G. Pitt, Beverly L. Roeder, Scott C. Steffersen, Alonzo D. Cook

Faculty Publications

Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor (NGF) is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine (LPC) has been shown to stimulate NGF receptors (NGFR). This study tested the administration of a single intraneural injection of LPC (1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections) at day 0 and one (day 7), two …

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Toxicity Of Selected Acaricides To Honey Bees (Apis Mellifera) And Varroa (Varroa Destructor Anderson And Trueman) And Their Use In Controlling Varroa Within Honey Bee Colonies, Aleš Gregorc, Mohamed Alburaki, Blair Sampson, John Adamczyk May 2018

Toxicity Of Selected Acaricides To Honey Bees (Apis Mellifera) And Varroa (Varroa Destructor Anderson And Trueman) And Their Use In Controlling Varroa Within Honey Bee Colonies, Aleš Gregorc, Mohamed Alburaki, Blair Sampson, John Adamczyk

Faculty Publications

The efficacies of various acaricides in order to control a parasitic mite, the Varroa mite, Varroa destructor, of honey bees, were measured in two different settings, namely, in laboratory caged honey bees and in queen-right honey bee colonies. The Varroa infestation levels before, during, and after the acaricide treatments were determined in two ways, namely: (1) using the sugar shake protocol to count mites on bees and (2) directly counting the dead mites on the hive bottom inserts. The acaricides that were evaluated were coumaphos, tau-fluvalinate, amitraz, thymol, and natural plant compounds (hop acids), which were the active ingredients. The …

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Metastatic Colon Adenocarcinoma Has A Significantly Elevated Expression Of Il-10 Compared With Primary Colon Adenocarcinoma Tumors, Michelle H. Townsend, Abigail M. Felsted, Stephen R. Piccolo, Richard A. Robison, Kim Oneill May 2018

Metastatic Colon Adenocarcinoma Has A Significantly Elevated Expression Of Il-10 Compared With Primary Colon Adenocarcinoma Tumors, Michelle H. Townsend, Abigail M. Felsted, Stephen R. Piccolo, Richard A. Robison, Kim Oneill

Faculty Publications

Classical anti-inflammatory cytokines are known to play a role in both cancer progression as well as cancer elimination. We evaluated the anti-inflammatory cytokines IL-10 and TGF-β in patients with colon adenocarcinoma and metastatic colon adenocarcinoma using immunohistochemical assays to determine the expression of the cytokines between various malignant tissues. We found tissues stained with TGF-β showed no significant upregulation within malignant tumors when compared with normal tissue controls. We observed high levels of TGF-β presence in most tissues similar to GAPDH expression. Within both colon adenocarcinoma and metastatic carcinomas there was a significant variability among patients in the expression of …

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The Sensitivity Of Future Ocean Oxygen To Changes In Ocean Circulation, Jaime B. Palter, David S. Trossman May 2018

The Sensitivity Of Future Ocean Oxygen To Changes In Ocean Circulation, Jaime B. Palter, David S. Trossman

Faculty Publications

No abstract provided.

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Physical Processes Dictate Early Biogeochemical Dynamics Of Soil Pyrogenic Organic Matter In A Subtropical Forest Ecosystem, Jason Stuart, Russell Anderson, Patrick Lazzarino, Kevin A. Kuehn, Omar R. Harvey May 2018

Physical Processes Dictate Early Biogeochemical Dynamics Of Soil Pyrogenic Organic Matter In A Subtropical Forest Ecosystem, Jason Stuart, Russell Anderson, Patrick Lazzarino, Kevin A. Kuehn, Omar R. Harvey

Faculty Publications

Quantifying links between pyOM dynamics, environmental factors and processes is central to predicting ecosystem function and response to future perturbations. In this study, changes in carbon (TC), nitrogen (TN), pH, and relative recalcitrance (R50) for pineand cordgrass-derived pyOM were measured at 3–6 weeks intervals throughout the first year of burial in the soil. Objectives were to (1) identify key environmental factors and processes driving early-stage pyOM dynamics, and (2) develop quantitative relationships between environmental factors and observed changes in pyOM properties. The study was conducted in sandy soils of a forested ecosystem within the Longleaf pine range of the United …

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Uswhy Does Not The Leaf Weight-Area Allometry Of Bamboos Follow The 3/2-Power Law?, Shuyan Lin, Lijuan Shao, Cang Hui, Yu Song, Gadi V.P. Reddy, Johan Gielis, Fang Li, Yulong Ding, Qiang Wei, Peijian Shi May 2018

Uswhy Does Not The Leaf Weight-Area Allometry Of Bamboos Follow The 3/2-Power Law?, Shuyan Lin, Lijuan Shao, Cang Hui, Yu Song, Gadi V.P. Reddy, Johan Gielis, Fang Li, Yulong Ding, Qiang Wei, Peijian Shi

Faculty Publications

The principle of similarity (Thompson, 1917) states that the weight of an organismfollows the 3/2-power law of its surface area and is proportional to its volume on the condition that the density is constant. However, the allometric relationship between leaf weight and leaf area has been reported to greatly deviate from the 3/2-power law, with the irregularity of leaf density largely ignored for explaining this deviation. Here, we choose 11 bamboo species to explore the allometric relationships among leaf area (A), density (ρ), length (L), thickness (T), and weight (W). Because the edge of a bamboo leaf follows a simplified …

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Radical Containing Combustion Derived Particulate Matter Enhance Pulmonary Th17 Inflammation Via The Aryl Hydrocarbon Receptor, Sridhar Jaligama, Vivek S. Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R. Mancuso, Tammy R. Dugas, Stephania A. Cormier May 2018

Radical Containing Combustion Derived Particulate Matter Enhance Pulmonary Th17 Inflammation Via The Aryl Hydrocarbon Receptor, Sridhar Jaligama, Vivek S. Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R. Mancuso, Tammy R. Dugas, Stephania A. Cormier

Faculty Publications

© 2018 The Author(s). Background: Pollutant particles containing environmentally persistent free radicals (EPFRs) are formed during many combustion processes (e.g. thermal remediation of hazardous wastes, diesel/gasoline combustion, wood smoke, cigarette smoke, etc.). Our previous studies demonstrated that acute exposure to EPFRs results in dendritic cell maturation and Th17-biased pulmonary immune responses. Further, in a mouse model of asthma, these responses were enhanced suggesting exposure to EPFRs as a risk factor for the development and/or exacerbation of asthma. The aryl hydrocarbon receptor (AHR) has been shown to play a role in the differentiation of Th17 cells. In the current study, we …

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Small-Angle X-Ray Scattering In Amorphous Silicon: A Computational Study, Durga Paudel, Raymond Atta-Fynn, David A. Drabold, Stephen R. Elliott, Parthapratim Biswas May 2018

Small-Angle X-Ray Scattering In Amorphous Silicon: A Computational Study, Durga Paudel, Raymond Atta-Fynn, David A. Drabold, Stephen R. Elliott, Parthapratim Biswas

Faculty Publications

We present a computational study of small-angle x-ray scattering (SAXS) in amorphous silicon (α-Si) with particular emphasis on the morphology and microstructure of voids. The relationship between the scattering intensity in SAXS and the three-dimensional structure of nanoscale inhomogeneities or voids is addressed by generating large high-quality (α-Si networks with 0.1%–0.3% volume concentration of voids, as observed in experiments using SAXS and positron annihilation spectroscopy. A systematic study of the variation of the scattering intensity in the small-angle scattering region with the size, shape, number density, and the spatial distribution of the voids in the networks is presented. Our results …

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A Time Course Study Of Rotavirus-Infected Intestinal Cells Treated With Stilbenoids And The Regulation Of Apoptosis, Rebecca D. Parr, Caleb M. Witcher, Rebekah Napier-Jameson, Hannah L. Wilson, Stormey Wisdom, Macie N. Mattila, Essence B. Strange, Josephine Taylor, Beatrice Clack, Fabricio Medina-Bolivar, Judith M. Ball May 2018

A Time Course Study Of Rotavirus-Infected Intestinal Cells Treated With Stilbenoids And The Regulation Of Apoptosis, Rebecca D. Parr, Caleb M. Witcher, Rebekah Napier-Jameson, Hannah L. Wilson, Stormey Wisdom, Macie N. Mattila, Essence B. Strange, Josephine Taylor, Beatrice Clack, Fabricio Medina-Bolivar, Judith M. Ball

Faculty Publications

This is a time course study of virus –host interactions that are modified with the addition of two small natural products. They appear to effect virus replication and the host response to the infection.

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Specialized Fibroblast Differentiated States Underlie Scar Formation In The Infarcted Mouse Heart, Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G. Boyer, Ronald J. Vagnozzi, Bryan D. Maliken, Michelle A. Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C. Blaxall, Jeffery D. Molkentin May 2018

Specialized Fibroblast Differentiated States Underlie Scar Formation In The Infarcted Mouse Heart, Xing Fu, Hadi Khalil, Onur Kanisicak, Justin G. Boyer, Ronald J. Vagnozzi, Bryan D. Maliken, Michelle A. Sargent, Vikram Prasad, Iñigo Valiente-Alandi, Burns C. Blaxall, Jeffery D. Molkentin

Faculty Publications

© 2018 Academic Press. All rights reserved. Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation. Fibroblasts were activated and highly proliferative, reaching a maximum rate within 2 to 4 days after infarction injury, at which point they expanded 3.5-fold …

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The Physical Limnology Of A Permanently Ice-Covered And Chemically Stratified Antarctic Lake Using High Resolution Spatial Data From An Autonomous Underwater Vehicle, Robert H. Spigel, John C. Priscu, Maciej K. Obryk, William Stone, Peter T. Doran May 2018

The Physical Limnology Of A Permanently Ice-Covered And Chemically Stratified Antarctic Lake Using High Resolution Spatial Data From An Autonomous Underwater Vehicle, Robert H. Spigel, John C. Priscu, Maciej K. Obryk, William Stone, Peter T. Doran

Faculty Publications

© 2018 The Authors Limnology and Oceanography published by Wiley Periodicals, Inc. on behalf of Association for the Sciences of Limnology and Oceanography We used an Environmentally Non-Disturbing Under-ice Robotic ANtarctic Explorer to make measurements of conductivity and temperature in Lake Bonney, a chemically stratified, permanently ice-covered Antarctic lake that abuts Taylor Glacier, an outlet glacier from the Polar Plateau. The lake is divided into two lobes – East Lobe Bonney (ELB) and West Lobe Bonney (WLB), each with unique temperature and salinity profiles. Most of our data were collected in November 2009 from WLB to examine the influence of …

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Allele And Dosage Specificity Of The Peg3 Imprinted Domain, Corey L. Bretz, Wesley D. Frey, Ryoichi Teruyama, Joomyeong Kim May 2018

Allele And Dosage Specificity Of The Peg3 Imprinted Domain, Corey L. Bretz, Wesley D. Frey, Ryoichi Teruyama, Joomyeong Kim

Faculty Publications

© 2018 Bretz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The biological impetus for gene dosage and allele specificity of mammalian imprinted genes is not fully understood. To address this, we generated and analyzed four sets of mice from a single breeding scheme with varying allelic expression and gene dosage of the Peg3 domain. The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease …

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Peanuts That Keep Aflatoxin At Bay: A Threshold That Matters, Kiran K. Sharma, Arunima Pothana, Kalyani Prasad, Dilip Shah, Jagdeep Kaur, Deepak Bhatnagar, Zhi Yuan Chen, Yenjit Raruang, Jeffrey W. Cary, Kanniah Rajasekaran, Hari Kishan Sudini, Pooja Bhatnagar-Mathur May 2018

Peanuts That Keep Aflatoxin At Bay: A Threshold That Matters, Kiran K. Sharma, Arunima Pothana, Kalyani Prasad, Dilip Shah, Jagdeep Kaur, Deepak Bhatnagar, Zhi Yuan Chen, Yenjit Raruang, Jeffrey W. Cary, Kanniah Rajasekaran, Hari Kishan Sudini, Pooja Bhatnagar-Mathur

Faculty Publications

Aflatoxin contamination in peanuts poses major challenges for vulnerable populations of sub-Saharan Africa and South Asia. Developing peanut varieties to combat preharvest Aspergillus flavus infection and resulting aflatoxin contamination has thus far remained a major challenge, confounded by highly complex peanut–Aspergilli pathosystem. Our study reports achieving a high level of resistance in peanut by overexpressing (OE) antifungal plant defensins MsDef1 and MtDef4.2, and through host-induced gene silencing (HIGS) of aflM and aflP genes from the aflatoxin biosynthetic pathway. While the former improves genetic resistance to A. flavus infection, the latter inhibits aflatoxin production in the event of infection providing durable …

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Childhood Adversity, Daily Stress, And Marital Strain In Same-Sex And Different-Sex Marriages, Rachel Donnelly, Debra Umberson, Rhiannon A. Kroeger May 2018

Childhood Adversity, Daily Stress, And Marital Strain In Same-Sex And Different-Sex Marriages, Rachel Donnelly, Debra Umberson, Rhiannon A. Kroeger

Faculty Publications

Childhood adversity has enduring consequences for individuals throughout life, including increased reactivity to stress that may contribute to marital strain in adulthood. Past research on gendered experiences of heterosexual spouses raises questions about how the influence of childhood adversity might differ for men and women in same-sex marriages. We analyze dyadic diary data from 756 individuals in 106 male same-sex, 157 female same-sex, and 115 different-sex marriages to consider how childhood adversity moderates the association between daily stress and marital strain. Results suggest that the negative consequences of daily stress for marital strain are amplified by past childhood adversity with …

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Identification Of Candidate Resistance Genes Of Cotton Against Aspergillus Flavus Infection Using A Comparative Transcriptomics Approach, Muthamilarasan Mehanathan, Renesh Bedre, Venkata Mangu, Kanniah Rajasekaran, Deepak Bhatnagar, Niranjan Baisakh May 2018

Identification Of Candidate Resistance Genes Of Cotton Against Aspergillus Flavus Infection Using A Comparative Transcriptomics Approach, Muthamilarasan Mehanathan, Renesh Bedre, Venkata Mangu, Kanniah Rajasekaran, Deepak Bhatnagar, Niranjan Baisakh

Faculty Publications

A comparative transcriptome analysis was performed using the genes significantly differentially expressed in cotton, corn and peanut in response to aflatoxin producing fungus Aspergillus flavus with an objective of identifying candidate resistance genes in cotton. Two-way analyses identified 732 unique genes to be differentially regulated by the fungus with only 26 genes common across all three crops that were considered candidate A. flavus resistance genes with an assumption that these genes have specific roles in conferring the resistance trait. Genes of membrane cellular component involved in DNA binding with involvement in defense responses were highly represented among the differentially expressed …

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Plant Responses To Fertilization Experiments In Lowland, Species-Rich, Tropical Forests, S. Joseph Wright, Benjamin L. Turner, Joseph B. Yavitt, Kyle E. Harms, Michael Kaspari, Edmund V.J. Tanner, Jelena Bujan, Eric A. Griffin, Jordan R. Mayor, Sarah C. Pasquini, Merlin Sheldrake, Milton N. Garcia May 2018

Plant Responses To Fertilization Experiments In Lowland, Species-Rich, Tropical Forests, S. Joseph Wright, Benjamin L. Turner, Joseph B. Yavitt, Kyle E. Harms, Michael Kaspari, Edmund V.J. Tanner, Jelena Bujan, Eric A. Griffin, Jordan R. Mayor, Sarah C. Pasquini, Merlin Sheldrake, Milton N. Garcia

Faculty Publications

© 2018 by the Ecological Society of America We present a meta-analysis of plant responses to fertilization experiments conducted in lowland, species-rich, tropical forests. We also update a key result and present the first species-level analyses of tree growth rates for a 15-yr factorial nitrogen (N), phosphorus (P), and potassium (K) experiment conducted in central Panama. The update concerns community-level tree growth rates, which responded significantly to the addition of N and K together after 10 yr of fertilization but not after 15 yr. Our experimental soils are infertile for the region, and species whose regional distributions are strongly associated …

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Climate Change And An Invasive, Tropical Milkweed: An Ecological Trap For Monarch Butterflies, Matthew J. Faldyn, Mark D. Hunter, Bret D. Elderd May 2018

Climate Change And An Invasive, Tropical Milkweed: An Ecological Trap For Monarch Butterflies, Matthew J. Faldyn, Mark D. Hunter, Bret D. Elderd

Faculty Publications

© 2018 by the Ecological Society of America While it is well established that climate change affects species distributions and abundances, the impacts of climate change on species interactions has not been extensively studied. This is particularly important for specialists whose interactions are tightly linked, such as between the monarch butterfly (Danaus plexippus) and the plant genus Asclepias, on which it depends. We used open-top chambers (OTCs) to increase temperatures in experimental plots and placed either nonnative Asclepias curassavica or native A. incarnata in each plot along with monarch larvae. We found, under current climatic conditions, adult monarchs had higher …

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Evaluating The Role Of Large Jellyfish And Forage Fishes As Energy Pathways, And Their Interplay With Fisheries, In The Northern Humboldt Current Systems, Luciano M. Chiaverino, Kelly L. Robinson, Jorge Tam, James J. Ruzicka, Javier Quiñones, Katrina Aleksa, Frank J. Hernandez Jr., Richard D. Brodeur, Robert T. Leaf, Shin-Ichi Uye, Mary Beth Decker, Marcelo Acha, Hermes Mianzan, William M. Graham May 2018

Evaluating The Role Of Large Jellyfish And Forage Fishes As Energy Pathways, And Their Interplay With Fisheries, In The Northern Humboldt Current Systems, Luciano M. Chiaverino, Kelly L. Robinson, Jorge Tam, James J. Ruzicka, Javier Quiñones, Katrina Aleksa, Frank J. Hernandez Jr., Richard D. Brodeur, Robert T. Leaf, Shin-Ichi Uye, Mary Beth Decker, Marcelo Acha, Hermes Mianzan, William M. Graham

Faculty Publications

Large jellyfish are important consumers of plankton, fish eggs and fish larvae in heavily fished ecosystems worldwide; yet they are seldom included in fisheries production models. Here we developed a trophic network model with 41 functional groups using ECOPATH re-expressed in a donor-driven, end-to-end format to directly evaluate the efficiency of large jellyfish and forage fish at transferring energy to higher trophic levels, as well as the ecosystem-wide effects of varying jellyfish and forage fish consumption rates and fishing rates, in the Northern Humboldt Current system (NHCS) off of Peru. Large jellyfish were an energy-loss pathway for high …

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Spatial Dynamics And Mixing Of Bluefin Tuna In The Atlantic Ocean And Mediterranean Sea Revealed Using Next-Generation Sequencing, Gregory N. Puncher, Alessia Cariani, Gregory E. Maes, Jeroen Van Houdt, Koen Herten, Rita Cannas, Naiara Rodriguez-Ezpeleta, Aitor Albania, Andone Estonba, Molly Lutcavage, Alex Hanke, Jay Rooker, James S. Franks, Joseph M. Quattro, Gualtiero Basilone, Igaratza Fraile, Urtzi Laconcha, Nicolas Goñi, Ai Kimoto, David Macías, Francisco Alemany, Simeon Deguara, Salem W. Zgozi, Fulvio Garibaldi, Isik K. Oray, Firdes Saadet Karakulak, Noureddine Abid, Miguel N. Santos, Piero Addis, Haritz Arrizabalaga, Fausto Tinti May 2018

Spatial Dynamics And Mixing Of Bluefin Tuna In The Atlantic Ocean And Mediterranean Sea Revealed Using Next-Generation Sequencing, Gregory N. Puncher, Alessia Cariani, Gregory E. Maes, Jeroen Van Houdt, Koen Herten, Rita Cannas, Naiara Rodriguez-Ezpeleta, Aitor Albania, Andone Estonba, Molly Lutcavage, Alex Hanke, Jay Rooker, James S. Franks, Joseph M. Quattro, Gualtiero Basilone, Igaratza Fraile, Urtzi Laconcha, Nicolas Goñi, Ai Kimoto, David Macías, Francisco Alemany, Simeon Deguara, Salem W. Zgozi, Fulvio Garibaldi, Isik K. Oray, Firdes Saadet Karakulak, Noureddine Abid, Miguel N. Santos, Piero Addis, Haritz Arrizabalaga, Fausto Tinti

Faculty Publications

The Atlantic bluefin tuna is a highly migratory species emblematic of the challenges associated with shared fisheries management. In an effort to resolve the species’ stock dynamics, a genomewide search for spatially informative single nucleotide polymorphisms (SNPs) was undertaken, by way of sequencing reduced representation libraries. An allele frequency approach to SNP discovery was used, combining the data of 555 larvae and young‐of‐the‐year (LYOY) into pools representing major geographical areas and mapping against a newly assembled genomic reference. From a set of 184,895 candidate loci, 384 were selected for validation using 167 LYOY. A highly discriminatory genotyping panel of 95 …

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Transitioning By Degrees: Becoming A Subject Librarian Through Advanced Education, Wendy G. Pothier May 2018

Transitioning By Degrees: Becoming A Subject Librarian Through Advanced Education, Wendy G. Pothier

Faculty Publications

This paper examines on librarian’s path from generalist librarian to subject specialist, with a focus on the value of additional advanced subject degrees in relationship to this work. Following the author’s career path from MLS to Business Librarian at a public university, the conversation also examines attitudes, perceptions, and frequency of additional advanced degrees in the literature.

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Association Between Toxoplasma Gondii Seropositivity And Memory Function In Non-Demented Older Adults, Cynthia Elizabeth Wyman, Shawn D. Gale, Ariana Hedges-Muncy, Lance D. Erickson, Eric Wilson, Dawson W. Hedges May 2018

Association Between Toxoplasma Gondii Seropositivity And Memory Function In Non-Demented Older Adults, Cynthia Elizabeth Wyman, Shawn D. Gale, Ariana Hedges-Muncy, Lance D. Erickson, Eric Wilson, Dawson W. Hedges

Faculty Publications

Toxoplasma gondii (T. gondii) seropositivity may be associated with decreased memory in older adults. To further investigate the association between T. gondii seropositivity and memory in nondemented older adults, we obtained serum samples from 114 non-demented older adults evaluated by the Alzheimer’s Disease and Research Center at Washington University in St. Louis Missouri, USA. We determined T. gondii seropositivity and anti-T. gondii IgG antibody titer and examined associations with memory function while controlling for socioeconomic status, education level, age, and apolipoprotein E4 status. There were few associations between T. gondii seropositivity or anti-T. gondii IgG antibodies and memory, although there …

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Nanoreactors: Strategies To Encapsulate Enzyme Biocatalysts In Virus-Like Particles, Joshua W. Wilkerson, Seung-Ook Yang, Parker J. Funk, Steven K. Stanley, Bradley Charles Bundy Apr 2018

Nanoreactors: Strategies To Encapsulate Enzyme Biocatalysts In Virus-Like Particles, Joshua W. Wilkerson, Seung-Ook Yang, Parker J. Funk, Steven K. Stanley, Bradley Charles Bundy

Faculty Publications

Enzyme-mediated biocatalysis is generally more selective and environmentally friendly and requires less energy than chemocatalysis. However, factors such as temperature, acidity and the presence of proteases can negate enzyme activity. Encapsulation in virus-like particles is one promising method to mitigate these difficulties. Encapsulation also can be used to create multi-reaction nanoreactors that increase process efficiency by isolating reaction intermediates. To successfully encapsulate enzymes, a variety of methods involving both non-covalent and covalent interactions have been developed. Here we review promising virus-like particle encapsulation strategies, their advantages and remaining challenges.

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Threshold-Dependent Repression Of Spl Gene Expression By Mir156/Mir157 Controls Vegetative Phase Change In Arabidopsis Thaliana, Jia He, Mingli Xu, Matthew R. Willmann, Kevin Mccormick, Tieqiang Hu, Li Yang, Colby G. Starker, Daniel F. Voytas, Blake C. Meyers, R. Scott Poethig Apr 2018

Threshold-Dependent Repression Of Spl Gene Expression By Mir156/Mir157 Controls Vegetative Phase Change In Arabidopsis Thaliana, Jia He, Mingli Xu, Matthew R. Willmann, Kevin Mccormick, Tieqiang Hu, Li Yang, Colby G. Starker, Daniel F. Voytas, Blake C. Meyers, R. Scott Poethig

Faculty Publications

Vegetative phase change is regulated by a decrease in the abundance of the miRNAs, miR156 and miR157, and the resulting increase in the expression of their targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors. To determine how miR156/miR157 specify the quantitative and qualitative changes in leaf morphology that occur during vegetative phase change, we measured their abundance in successive leaves and characterized the phenotype of mutations in different MIR156 and MIR157 genes. miR156/miR157 decline rapidly between leaf 1&2 and leaf 3 and decrease more slowly after this point. The amount of miR156/miR157 in leaves 1&2 greatly exceeds the …

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Scales Of Seafloor Sediment Resuspension In The Northern Gulf Of Mexico, Arne-R. Diercks, Clayton Dike, Vernon Asper, Steven F. Dimarco, Jeff Chanton, Uta Passow Apr 2018

Scales Of Seafloor Sediment Resuspension In The Northern Gulf Of Mexico, Arne-R. Diercks, Clayton Dike, Vernon Asper, Steven F. Dimarco, Jeff Chanton, Uta Passow

Faculty Publications

Seafloor sediment resuspension events of different scales and magnitudes and the resulting deep (>1,000 m) benthic nepheloid layers were investigated in the northern Gulf of Mexico during Fall 2012 to Summer 2013. Time-series data of size-specific in-situ settling speeds of marine snow in the benthic nepheloid layer (moored flux cameras), particle size distributions (profiling camera), currents (various current meters) and stacked time-series flux data (sediment traps) were combined to recognize resuspension events ranging from small-scale local, to small-scale far-field to hurricane-scale. One smallscale local resuspension event caused by inertial currents was identified based on local high current speeds ( …

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Functioning Of Coastal River-Dominated Ecosystems And Implications For Oil Spill Response: From Observations To Mechanisms And Models, Adam T. Greer, Alan M. Shiller, Eileen E. Hoffman, Jerry D. Wiggert, Sally J. Warner, Sabrina M. Parra, Chudong Pan, Jeffrey W. Book, Dongjoo Joung, Steven K. Dykstra, Jeffrey W. Krause, Brian Dzwonkowski, Inia M. Soto, M. Kemal Cambazoglu, Alison L. Deary, Christian Briseño-Avena, Adam D. Boyette, Jessica A. Kastler, Virginie Sanial, Laura Hode, Uchenna Nwankwo, Luciano M. Chiaverano, Stephan J. O'Brien, Patrick J. Fitzpatrick, Yee H. Lau, Michael S. Dinniman, Kevin M. Martin, Peng Ho, Allison K. Mojzis, Stephan D. Howden, Frank J. Hernandez, Ian Church, Travis N. Miles, Su Sponaugle, James N. Moum, Robert A. Arnone, Robert K. Cowen, Gregg A. Jacobs, Oscar Schofield, William M. Graham Apr 2018

Functioning Of Coastal River-Dominated Ecosystems And Implications For Oil Spill Response: From Observations To Mechanisms And Models, Adam T. Greer, Alan M. Shiller, Eileen E. Hoffman, Jerry D. Wiggert, Sally J. Warner, Sabrina M. Parra, Chudong Pan, Jeffrey W. Book, Dongjoo Joung, Steven K. Dykstra, Jeffrey W. Krause, Brian Dzwonkowski, Inia M. Soto, M. Kemal Cambazoglu, Alison L. Deary, Christian Briseño-Avena, Adam D. Boyette, Jessica A. Kastler, Virginie Sanial, Laura Hode, Uchenna Nwankwo, Luciano M. Chiaverano, Stephan J. O'Brien, Patrick J. Fitzpatrick, Yee H. Lau, Michael S. Dinniman, Kevin M. Martin, Peng Ho, Allison K. Mojzis, Stephan D. Howden, Frank J. Hernandez, Ian Church, Travis N. Miles, Su Sponaugle, James N. Moum, Robert A. Arnone, Robert K. Cowen, Gregg A. Jacobs, Oscar Schofield, William M. Graham

Faculty Publications

Coastal river-dominated oceans are physically complex, biologically productive, and intimately connected to human socioeconomic activity. The Deepwater Horizon blowout and subsequent advection of oil into coastal waters of the northern Gulf of Mexico (nGOM) highlighted the complex linkages among oceanographic processes within this river-dominated system and knowledge gaps about it that resulted in imprecise information on both oil transport and ecosystem consequences. The interdisciplinary research program implemented through the CONsortium for oil exposure pathways in COastal River-Dominated Ecosystems (CONCORDE) is designed to identify and quantitatively assess key physical, biological, and geochemical processes acting in the nGOM, in order to provide …

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Modeling Canopy-Induced Turbulence In The Earth System: A Unified Parameterization Of Turbulent Exchange Within Plant Canopies And The Roughness Sublayer (Clm-Ml V0), Gordon B. Bonan, Edward G. Patton, Ian N. Harman, Keith W. Oleson, John J. Finnigan, Yaqiong Lu, Elizabeth A. Burakowski Apr 2018

Modeling Canopy-Induced Turbulence In The Earth System: A Unified Parameterization Of Turbulent Exchange Within Plant Canopies And The Roughness Sublayer (Clm-Ml V0), Gordon B. Bonan, Edward G. Patton, Ian N. Harman, Keith W. Oleson, John J. Finnigan, Yaqiong Lu, Elizabeth A. Burakowski

Faculty Publications

Land surface models used in climate models neglect the roughness sublayer and parameterize within-canopy turbulence in an ad hoc manner. We implemented a roughness sublayer turbulence parameterization in a multilayer canopy model (CLM-ml v0) to test if this theory provides a tractable parameterization extending from the ground through the canopy and the roughness sublayer. We compared the canopy model with the Community Land Model (CLM4.5) at seven forest, two grassland, and three cropland AmeriFlux sites over a range of canopy heights, leaf area indexes, and climates. CLM4.5 has pronounced biases during summer months at forest sites in midday latent heat …

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Development Of An Autodissemination Strategy For The Deployment Of Novel Control Agents Targeting The Common Malaria Mosquito, Anopheles Quadrimaculatus Say (Diptera: Culicidae), Daniel R. Swale, Zhilin Li, Jake Z. Kraft, Kristen Healy, Mei Liu, Connie M. David, Zhijun Liu, Lane D. Foil Apr 2018

Development Of An Autodissemination Strategy For The Deployment Of Novel Control Agents Targeting The Common Malaria Mosquito, Anopheles Quadrimaculatus Say (Diptera: Culicidae), Daniel R. Swale, Zhilin Li, Jake Z. Kraft, Kristen Healy, Mei Liu, Connie M. David, Zhijun Liu, Lane D. Foil

Faculty Publications

© 2018 Swale et al. Background: The reduced efficacy of current Anopheline mosquito control methods underscores the need to develop new methods of control that exploit unique target sites and/or utilizes novel deployment methods. Autodissemination methodologies using insect growth regulators (IGRs) is growing in interest and has been shown to be effective at controlling Aedes mosquitoes in semi-field and field environments, yet little information exists for Anopheline mosquitoes. Therefore, we tested the hypothesis that female-driven autodissemination of an IGR combined with a new mechanism of action insecticide (Kir channel inhibitor) could be employed to reduce Anopheline populations. Methodology: We studied …

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Multiple Episodes Of Extensive Marine Anoxia Linked To Global Warming And Continental Weathering Following The Latest Permian Mass Extinction, Feifei Zhang, Stephen J. Romaniello, Thomas J. Algeo, Kimberly V. Lau, Matthew E. Clapham, Sylvain Richoz, Achim D. Herrmann, Harrison Smith, Micha Horacek, Ariel D. Anbar Apr 2018

Multiple Episodes Of Extensive Marine Anoxia Linked To Global Warming And Continental Weathering Following The Latest Permian Mass Extinction, Feifei Zhang, Stephen J. Romaniello, Thomas J. Algeo, Kimberly V. Lau, Matthew E. Clapham, Sylvain Richoz, Achim D. Herrmann, Harrison Smith, Micha Horacek, Ariel D. Anbar

Faculty Publications

Copyright © 2018 The Authors. Explaining the ∼5-million-year delay in marine biotic recovery following the latest Permian mass extinction, the largest biotic crisis of the Phanerozoic, is a fundamental challenge for both geological and biological sciences. Ocean redox perturbations may have played a critical role in this delayed recovery. However, the lack of quantitative constraints on the details of Early Triassic oceanic anoxia (for example, time, duration, and extent) leaves the links between oceanic conditions and the delayed biotic recovery ambiguous. We report high-resolution U-isotope (δ238U) data from carbonates of the uppermost Permian to lowermost Middle Triassic Zal section (Iran) …

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