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Erepo-Orp: Exploring The Opportunity Space To Combat Orphan Diseases With Existing Drugs, Michal Brylinski, Misagh Naderi, Rajiv Gandhi Govindaraj, Jeffrey Lemoine Jul 2018

Erepo-Orp: Exploring The Opportunity Space To Combat Orphan Diseases With Existing Drugs, Michal Brylinski, Misagh Naderi, Rajiv Gandhi Govindaraj, Jeffrey Lemoine

Faculty Publications

© 2017 About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individual markets. Consequently, developing new treatments for often life-threatening orphan diseases is primarily contingent on financial incentives from governments, special research grants, and private philanthropy. Computer-aided drug repositioning is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research. Here, we present eRepo-ORP, a comprehensive resource constructed by a large-scale repositioning of existing drugs to orphan diseases …

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L-Citrulline Supplementation: Impact On Cardiometabolic Health, Timothy D. Allerton, David N. Proctor, Jacqueline M. Stephens, Tammy R. Dugas, Guillaume Spielmann, Brian A. Irving Jul 2018

L-Citrulline Supplementation: Impact On Cardiometabolic Health, Timothy D. Allerton, David N. Proctor, Jacqueline M. Stephens, Tammy R. Dugas, Guillaume Spielmann, Brian A. Irving

Faculty Publications

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in the regulation of numerous vital biological functions, contributes to the development and progression of multiple age-and lifestyle-related diseases. While L-arginine is the precursor for the synthesis of NO by endothelial-nitric oxide synthase (eNOS), oral L-arginine supplementation is largely ineffective at increasing NO synthesis and/or bioavailability for a variety of reasons. L-citrulline, found in high concentrations in watermelon, is a neutral alpha-amino acid formed by enzymes in the mitochondria that also serves as a substrate for recycling L-arginine. Unlike L-arginine, …

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Smokers' Neurological Responses To Novel And Repeated Health Warning Labels (Hwls) From Cigarette Packages, Johann F. Fridriksson, Chris Rorden, Roger D. Newman-Norlund, Brett Froeliger, Jim Thrasher Jul 2018

Smokers' Neurological Responses To Novel And Repeated Health Warning Labels (Hwls) From Cigarette Packages, Johann F. Fridriksson, Chris Rorden, Roger D. Newman-Norlund, Brett Froeliger, Jim Thrasher

Faculty Publications

Graphic health warning labels (HWLs) depicting bodily injury due to smoking are effective for producing changes in affect, cognition and smoking behavior in adult smokers. However, little is known about the effects of repeated presentation of graphic HWL’s on the aforementioned processes. The goal of this study was to examine neural and behavioral responses to graphic HWL’s and evaluate whether the repeated presentation of graphic HWL’s leads to repetition suppression (RS). Smokers (N = 16) performed an event-related HWL cue task while blood oxygen level dependent (BOLD) signal was collected during a functional magnetic resonance imaging (fMRI) experimental session. Consistent …

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Future Research Directions In Pneumonia, Charles S. Dela Cruz, Richard G. Wunderink, David C. Christiani, Stephania A. Cormier, Kristina Crothers, Claire M. Doerschuk, Scott E. Evans, Daniel R. Goldstein, Purvesh Khatri, Lester Kobzik, Jay K. Kolls, Bruce D. Levy, Mark L. Metersky, Michael S. Niederman, Roomi Nusrat, Carlos J. Orihuela, Paula Peyrani, Alice S. Prince, Julio A. Ramírez, Karen M. Ridge, Sanjay Sethi, Benjamin T. Suratt, Jacob I. Sznajder, Ephraim L. Tsalik, Allan J. Walkey, Sachin Yende, Neil R. Aggarwal, Elisabet V. Caler, Joseph P. Mizgerd Jul 2018

Future Research Directions In Pneumonia, Charles S. Dela Cruz, Richard G. Wunderink, David C. Christiani, Stephania A. Cormier, Kristina Crothers, Claire M. Doerschuk, Scott E. Evans, Daniel R. Goldstein, Purvesh Khatri, Lester Kobzik, Jay K. Kolls, Bruce D. Levy, Mark L. Metersky, Michael S. Niederman, Roomi Nusrat, Carlos J. Orihuela, Paula Peyrani, Alice S. Prince, Julio A. Ramírez, Karen M. Ridge, Sanjay Sethi, Benjamin T. Suratt, Jacob I. Sznajder, Ephraim L. Tsalik, Allan J. Walkey, Sachin Yende, Neil R. Aggarwal, Elisabet V. Caler, Joseph P. Mizgerd

Faculty Publications

Copyright © 2018 by the American Thoracic Society. Pneumonia is a complex pulmonary disease in need of new clinical approaches. Although triggered by a pathogen, pneumonia often results from dysregulations of host defense that likely precede infection. The coordinated activities of immune resistance and tissue resilience then dictate whether and how pneumonia progresses or resolves. Inadequate or inappropriate host responses lead to more severe outcomes such as acute respiratory distress syndrome and to organ dysfunction beyond the lungs and over extended time frames after pathogen clearance, some of which increase the risk for subsequent pneumonia. Improved understanding of such host …

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Polycyclic Aromatic Hydrocarbon Exposure In Seaside Sparrows (Ammodramus Maritimus) Following The 2010 Deepwater Horizon Oil Spill, Anna A. Perez-Umphrey, Christine M. Bergeon Burns, Philip C. Stouffer, Stefan Woltmann, Sabrina S. Taylor Jul 2018

Polycyclic Aromatic Hydrocarbon Exposure In Seaside Sparrows (Ammodramus Maritimus) Following The 2010 Deepwater Horizon Oil Spill, Anna A. Perez-Umphrey, Christine M. Bergeon Burns, Philip C. Stouffer, Stefan Woltmann, Sabrina S. Taylor

Faculty Publications

The seaside sparrow (Ammodramus maritimus) is an abundant and permanent resident of coastal salt marshes impacted by the 2010 BP Deepwater Horizon oil spill. Such terrestrial species are often overlooked in the aftermath of marine spills, despite the potential for long-term oil exposure. We sampled the livers of seaside sparrows residing in oiled and unoiled sites from 2011 to 2014 and quantified expression of cytochrome p450 1A (CYP1A), a gene involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). In August 2011, CYP1A expression was markedly higher in birds from an oiled site compared to an unoiled site, but differences …

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Evolving Paradigms In Biological Carbon Cycling In The Ocean, Chuanlun Zhang, Hongyue Dang, Farooq Azam, Ronald Benner, Louis Legendre, Uta Passow, Luca Polimene, Carol Robinson, Curtis A. Suttle, Nianzhi Jiao Jul 2018

Evolving Paradigms In Biological Carbon Cycling In The Ocean, Chuanlun Zhang, Hongyue Dang, Farooq Azam, Ronald Benner, Louis Legendre, Uta Passow, Luca Polimene, Carol Robinson, Curtis A. Suttle, Nianzhi Jiao

Faculty Publications

Carbon is a keystone element in global biogeochemical cycles. It plays a fundamental role in biotic and abiotic processes in the ocean, which intertwine to mediate the chemistry and redox status of carbon in the ocean and the atmosphere. The interactions between abiotic and biogenic carbon (e.g. CO2, CaCO3, organic matter) in the ocean are complex, and there is a half-century-old enigma about the existence of a huge reservoir of recalcitrant dissolved organic carbon (RDOC) that equates to the magnitude of the pool of atmospheric CO2. The concepts of the biological carbon pump (BCP) …

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Sediment Characteristics And Methane Ebullition In Three Subarctic Lakes, Martin Wik, Joel E. Johnson, Patrick M. Crill, Joel P. Destasio, Lance Erickson, Madison J. Halloran, Maria Florencia Fahnestock, Maurice K. Crawford, Stephen C. Phillips, Ruth K. Varner Jul 2018

Sediment Characteristics And Methane Ebullition In Three Subarctic Lakes, Martin Wik, Joel E. Johnson, Patrick M. Crill, Joel P. Destasio, Lance Erickson, Madison J. Halloran, Maria Florencia Fahnestock, Maurice K. Crawford, Stephen C. Phillips, Ruth K. Varner

Faculty Publications

Ebullition (bubbling) from climate‐sensitive northern lakes remains an unconstrained source of atmospheric methane (CH4). Although the focus of many recent studies, ebullition is rarely linked to the physical characteristics of lakes. In this study we analyze the sediments of subarctic postglacial lakes and investigate how sediment properties relate to the large spatial variation in CH4 bubble flux, quantified over multiple years using bubble traps. The results show that the sediments from our lakes are rich in total organic carbon, containing 37 kg/m3 on average. This number is roughly 40% higher than the average for yedoma deposits, which have been identified …

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The New Family Freedom, Emily J. Stolzenberg Jul 2018

The New Family Freedom, Emily J. Stolzenberg

Faculty Publications

In family law, “autonomy” has traditionally meant freedom from state interference in one’s intimate life. This Article describes an emergent, libertarian vision of autonomy as property rights that also demands freedom from other family members. This conception, “choice about obligations,” holds redistribution of resources between intimates to be illegitimate unless the richer party “chose” to take on financial obligations ex ante by ceremonially marrying or formally contracting. But as more people conduct their intimate lives outside these legal institutions, choice about obligations increasingly collides with another, more fundamental, family law principle: the imperative to “privatize dependency,” i.e., to redistribute resources …

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Annotated Bibliography Of The Global Literature On The Secondary Transportation Of Raw And Comminuted Forest Products (2000-2015), Anil Koirala, Anil Raj Kizha, Cornelis F. De Hoop, Brian E. Roth, Han Sup Han, Patrick Hiesl, Dalia Abbas, Shuva Gautam, Srijana Baral, Steve Bick, Kamalakanta Sahoo Jul 2018

Annotated Bibliography Of The Global Literature On The Secondary Transportation Of Raw And Comminuted Forest Products (2000-2015), Anil Koirala, Anil Raj Kizha, Cornelis F. De Hoop, Brian E. Roth, Han Sup Han, Patrick Hiesl, Dalia Abbas, Shuva Gautam, Srijana Baral, Steve Bick, Kamalakanta Sahoo

Faculty Publications

Secondary transportation of raw and comminuted forest products is a major component in forest harvesting operations in terms of economics, public perception, and safety. Consequently, there is a substantial amount of literature on this topic. The existing literature has dealt with many of the technical aspects of transportation with a majority of them focusing on improving supply chain issues; however, there are only few specific to secondary transportation issues in general. This annotated bibliography will help practitioners, researchers, and stakeholders gain a better understanding of the existing literature from 2000 to 2015. To this end, we began by classifying the …

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Litter Identity Affects Assimilation Of Carbon And Nitrogen By A Shredding Caddisfly, Adam C. Siders, Zacchaeus G. Compson, Bruce A. Hungate, Paul Dijkstra, George W. Koch, Adam S. Wymore, A. Stuart Grandy, Jane C. Marks Jul 2018

Litter Identity Affects Assimilation Of Carbon And Nitrogen By A Shredding Caddisfly, Adam C. Siders, Zacchaeus G. Compson, Bruce A. Hungate, Paul Dijkstra, George W. Koch, Adam S. Wymore, A. Stuart Grandy, Jane C. Marks

Faculty Publications

Ecologists often equate litter quality with decomposition rate. In soil and sediments, litter that is rapidly decomposed by microbes often has low concentrations of tannin and lignin and low C:N ratios. Do these same traits also favor element transfer to higher trophic levels in streams, where many insects depend on litter as their primary food source? We test the hypothesis that slow decomposition rates promote element transfer from litter to insects, whereas rapid decomposition favors microbes. We measured carbon and nitrogen fluxes from four plant species to a leaf-shredding caddisfly using isotopically labeled litter. Caddisflies assimilated a higher percentage of …

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Aerosol Microdroplets Exhibit A Stable Ph Gradient, Haoran Wei, Eric P. Vejerano, Weinan Leng, Qishen Haung, Marjorie R. Willner, Linsey C. Marr, Peter J. Vikesland Jul 2018

Aerosol Microdroplets Exhibit A Stable Ph Gradient, Haoran Wei, Eric P. Vejerano, Weinan Leng, Qishen Haung, Marjorie R. Willner, Linsey C. Marr, Peter J. Vikesland

Faculty Publications

Suspended aqueous aerosol droplets (<50 μm) are microreactors for many important atmospheric reactions. In droplets and other aquatic environments, pH is arguably the key parameter dictating chemical and biological processes. The nature of the droplet air/ water interface has the potential to significantly alter droplet pH relative to bulk water. Historically, it has been challenging to measure the pH of individual droplets because of their inaccessibility to conventional pH probes. In this study, we scanned droplets containing 4-mercaptobenzoic acid–functionalized gold nanoparticle pH nanoprobes by 2D and 3D laser confocal Raman microscopy. Using surface-enhanced Raman scattering, we acquired the pH distribution inside approximately 20-μm-diameter phosphate-buffered aerosol droplets and found that the pH in the core of a droplet is higher than that of bulk solution by up to 3.6 pH units. This finding suggests the accumulation of protons at the air/water interface and is consistent with recent thermodynamic model results. The existence of this pH shift was corroborated by the observation that a catalytic reaction that occurs only under basic conditions (i.e., dimerization of 4-aminothiophenol to produce dimercaptoazobenzene) occurs within the high pH core of a droplet, but not in bulk solution. Our nanoparticle probe enables pH quantification through the cross-section of an aerosol droplet, revealing a spatial gradient that has implications for acid-base–catalyzed atmospheric chemistry.

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An Implementation Strategy To Quantify The Marine Microbial Carbon Pump And Its Sensitivity To Global Change, Carol Robinson, Douglas Wallace, Jung-Ho Hyun, Luca Polimene, Ronald Benner, Yao Zhang, Ruanhong Cai, Rui Zhang, Nianzhi Jiao Jul 2018

An Implementation Strategy To Quantify The Marine Microbial Carbon Pump And Its Sensitivity To Global Change, Carol Robinson, Douglas Wallace, Jung-Ho Hyun, Luca Polimene, Ronald Benner, Yao Zhang, Ruanhong Cai, Rui Zhang, Nianzhi Jiao

Faculty Publications

No abstract provided.

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A Bayesian Phase I/Ii Trial Design For Immunotherapy, Suyu Liu, Beibei Guo, Ying Yuan Jul 2018

A Bayesian Phase I/Ii Trial Design For Immunotherapy, Suyu Liu, Beibei Guo, Ying Yuan

Faculty Publications

Immunotherapy is an innovative treatment approach that stimulates a patient’s immune system to fight cancer. It demonstrates characteristics distinct from conventional chemotherapy and stands to revolutionize cancer treatment. We propose a Bayesian phase I/II dose-finding design that incorporates the unique features of immunotherapy by simultaneously considering three outcomes: immune response, toxicity, and efficacy. The objective is to identify the biologically optimal dose, defined as the dose with the highest desirability in the risk–benefit tradeoff. An Emax model is utilized to describe the marginal distribution of the immune response. Conditional on the immune response, we jointly model toxicity and efficacy using …

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Removal Of Total Dissolved Solids From Reverse Osmosis Concentrates From A Municipal Wastewater Reclamation Plant By Aerobic Granular Sludge, Do-Hyung Kim, Sangjin Park, Yeomin Yoon, Chang Min Park Jul 2018

Removal Of Total Dissolved Solids From Reverse Osmosis Concentrates From A Municipal Wastewater Reclamation Plant By Aerobic Granular Sludge, Do-Hyung Kim, Sangjin Park, Yeomin Yoon, Chang Min Park

Faculty Publications

Reverse osmosis (RO) has been widely utilized in water reclamation plants and produces a concentrated brine (or reject) stream as a by-product. RO concentrates (ROC) contain vast quantities of salts and dissolved organic matter, such as biomass and humic-like substances, which hinder biological wastewater treatment (such as biological nitrogen removal). In this study, we cultivated granular sludge in an aerobic sequencing batch reactor to treat municipal wastewater with an organic loading rate of 2.1–4.3 kgCOD/m3 day at room temperature (25 °C), and remove total dissolved solids (TDS) from ROC by biosorption, with aerobic granular sludge as a novel biosorbent. …

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Hydrogels For Cell Delivery, Esmaiel Jabbari Jul 2018

Hydrogels For Cell Delivery, Esmaiel Jabbari

Faculty Publications

No abstract provided.

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A Neuromorphic Quadratic, Integrate, And Fire Silicon Neuron With Adaptive Gain, David Parent, Eric Basham Jul 2018

A Neuromorphic Quadratic, Integrate, And Fire Silicon Neuron With Adaptive Gain, David Parent, Eric Basham

Faculty Publications

An integrated circuit implementation of a silicon neuron was designed, manufactured, and tested. The circuit was designed using the Quadratic, Integrate, and Fire (QIF) neuron model in 0.5 µm silicon technology. The neuron implementation was optimized for low current consumption, drawing only 1.56 mA per QIF circuit and utilized hysteretic reset, non-inverting integrator, and voltage-squarer circuits. The final area of each circuit in silicon was 268 µm height × 400 µm width. This design is the first IC of its kind for this neuron model and is successfully able to output true spiking that follows the behaviors of bistability, monotonic, …

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Island Edge Morphodynamics Along A Chronosequence In A Prograding Deltaic Floodplain Wetland, Azure E. Bevington, Robert R. Twilley Jul 2018

Island Edge Morphodynamics Along A Chronosequence In A Prograding Deltaic Floodplain Wetland, Azure E. Bevington, Robert R. Twilley

Faculty Publications

Much of the previous research on coastal deltaic land building has focused on the planform delta dimensions; whereas this research focuses on shifts in vertical elevation and deltaic island edge cross-sectional morphology in relation to a proposed conceptual model of deltaic island edge morphological development. This study was conducted using data collected from the Wax Lake Delta in the northern Gulf of Mexico. Island edge cross-sectional elevation profiles were extracted from a 2012 LIDAR elevation survey. Four morphometric variables (levee width, interior slope, mean elevation range, and total elevation range) were selected to describe the shape of each of these …

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Malleilactone Is A Burkholderia Pseudomallei Virulence Factor Regulated By Antibiotics And Quorum Sensing, Jennifer R. Klaus, Jacqueline Deay, Benjamin Neuenswander, Wyatt Hursh, Zhe Gao, Tiffany Bouddhara, Todd D. Williams, Justin Douglas, Kyle Monize, Patricia Martins, Charlotte Majerczyk, Mohammad R. Seyedsayamdost, Blake R. Peterson, Mario Rivera, Josephine R. Chandler Jul 2018

Malleilactone Is A Burkholderia Pseudomallei Virulence Factor Regulated By Antibiotics And Quorum Sensing, Jennifer R. Klaus, Jacqueline Deay, Benjamin Neuenswander, Wyatt Hursh, Zhe Gao, Tiffany Bouddhara, Todd D. Williams, Justin Douglas, Kyle Monize, Patricia Martins, Charlotte Majerczyk, Mohammad R. Seyedsayamdost, Blake R. Peterson, Mario Rivera, Josephine R. Chandler

Faculty Publications

© 2018 American Society for Microbiology. Burkholderia pseudomallei, the causative agent of melioidosis, encodes almost a dozen predicted polyketide (PK) biosynthetic gene clusters. Many of these are regulated by LuxR-I-type acyl-homoserine (AHL) quorum-sensing systems. One of the PK gene clusters, the mal gene cluster, is conserved in the close relative Burkholderia thailandensis. The B. thailandensis mal genes code for the cytotoxin malleilactone and are regulated by a genetically linked LuxR-type transcription factor, MalR. Although AHLs typically interact with LuxR-type proteins to modulate gene transcription, the B. thailandensis MalR does not appear to be an AHL receptor. Here, we characterize the …

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The Behavior Of Metropolis-Coupled Markov Chains When Sampling Rugged Phylogenetic Distributions, Jeremy M. Brown, Robert C. Thomson Jul 2018

The Behavior Of Metropolis-Coupled Markov Chains When Sampling Rugged Phylogenetic Distributions, Jeremy M. Brown, Robert C. Thomson

Faculty Publications

© The Author(s) 2018. Bayesian phylogenetic inference relies on the use of Markov chain Monte Carlo (MCMC) to provide numerical approximations of high-dimensional integrals and estimate posterior probabilities. However, MCMC performs poorly when posteriors are very rugged (i.e., regions of high posterior density are separated by regions of low posterior density). One technique that has become popular for improving numerical estimates from MCMC when distributions are rugged is Metropolis coupling (MC3). InMC3, additional chains are employed to sample flattened transformations of the posterior and improve mixing. Here, we highlight several underappreciated behaviors of MC3. Notably, estimated posterior probabilities may be …

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Liquid Sucrose Consumption Promotes Obesity And Impairs Glucose Tolerance Without Altering Circulating Insulin Levels, Susan J. Burke, Heidi M. Batdorf, Thomas M. Martin, David H. Burk, Robert C. Noland, Christopher R. Cooley, Michael D. Karlstad, William D. Johnson, J. Jason Collier Jul 2018

Liquid Sucrose Consumption Promotes Obesity And Impairs Glucose Tolerance Without Altering Circulating Insulin Levels, Susan J. Burke, Heidi M. Batdorf, Thomas M. Martin, David H. Burk, Robert C. Noland, Christopher R. Cooley, Michael D. Karlstad, William D. Johnson, J. Jason Collier

Faculty Publications

© 2018 The Obesity Society Objective: Multiple factors contribute to the rising rates of obesity and to difficulties in weight reduction that exist in the worldwide population. Caloric intake via sugar-sweetened beverages may be influential. This study tested the hypothesis that liquid sucrose intake promotes obesity by increasing serum insulin levels and tissue lipid accumulation. Methods: C57BL/6J mice were given 30% sucrose in liquid form. Changes in weight gain, body composition, energy expenditure (EE), and tissue lipid content were measured. Results: Mice drinking sucrose gained more total body mass (TBM), had greater fat mass, and displayed impaired glucose tolerance relative …

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Synthesis And In Vitro Pdt Evaluation Of New Porphyrins Containing Meso-Epoxymethylaryl Cationic Groups, Jaqueline Carneiro, Alan Gonçalves, Zehua Zhou, Kaitlin E. Griffin, Nichole E.M. Kaufman, Maria Da Graça Henriques Vicente Jul 2018

Synthesis And In Vitro Pdt Evaluation Of New Porphyrins Containing Meso-Epoxymethylaryl Cationic Groups, Jaqueline Carneiro, Alan Gonçalves, Zehua Zhou, Kaitlin E. Griffin, Nichole E.M. Kaufman, Maria Da Graça Henriques Vicente

Faculty Publications

© 2018 Wiley Periodicals, Inc. Objectives: Photodynamic therapy (PDT) is an effective cancer treatment that uses photosensitizers, light, and oxygen to destroy malignant cells. Porphyrins, and in particular the cationic derivatives, are the most investigated photosensitizers for PDT. In this context, it is important to study new methodologies to develop efficient cationic photosensitizers for use in PDT. Materials and Methods: New porphyrins bearing cationic epoxymethylaryl groups were synthesized and characterized. Their cellular uptake, intracellular localization, and phototoxicity were evaluated in human HEp2 cells, and compared with their methylated analogs. Results: All cationic porphyrins were efficient generators of singlet oxygen, with …

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Inhibition Of Endocytosis Suppresses The Nitric Oxide-Dependent Release Of Cl- In Retinal Amacrine Cells, Vernon K. Dunn, Evanna Gleason Jul 2018

Inhibition Of Endocytosis Suppresses The Nitric Oxide-Dependent Release Of Cl- In Retinal Amacrine Cells, Vernon K. Dunn, Evanna Gleason

Faculty Publications

© 2018 Dunn, Gleason. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Our lab has previously shown that nitric oxide (NO) can alter the synaptic response properties of amacrine cells by releasing Cl- from internal acidic compartments. This alteration in the Cl- gradient brings about a positive shift in the reversal potential of the GABA-gated current, which can convert inhibitory synapses into excitatory synapses. Recently, we have shown that the cystic fibrosis transmembrane regulator …

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Pheromone-Trap Monitoring System For Pea Leaf Weevil, Sitona Lineatus: Effects Of Trap Type, Lure Type And Trap Placement Within Fields, Gadi V.P. Reddy, Govinda Shrestha, Debra A. Miller, A. Cameron Oehlschlager Jul 2018

Pheromone-Trap Monitoring System For Pea Leaf Weevil, Sitona Lineatus: Effects Of Trap Type, Lure Type And Trap Placement Within Fields, Gadi V.P. Reddy, Govinda Shrestha, Debra A. Miller, A. Cameron Oehlschlager

Faculty Publications

The pea leaf weevil, Sitona lineatus, is an important pest of field peas and faba beans worldwide. Present sampling techniques that rely on detection of adult feeding damage are labor intensive, time consuming and require repeated sampling. Semiochemical-based pest monitoring systems could improve pea leaf weevil management. This study, which was conducted in the Golden Triangle region of Montana, tested several factors that potentially might affect capture rates of pheromone-baited traps, including trap and lure type and trap placement. Pheromone-baited pitfall and ramp traps caught significantly more adults than ground or delta traps, in all study areas. Pitfall traps baited …

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Management Of Insect Pests In The Production And Storage Of Minor Pulses, Ruparao T. Gahukar, Gadi V.P. Reddy Jul 2018

Management Of Insect Pests In The Production And Storage Of Minor Pulses, Ruparao T. Gahukar, Gadi V.P. Reddy

Faculty Publications

Minor pulses are cultivated on a small scale by economically poor farming communities for subsistence food. Currently, these crops are under-utilized or neglected, although they are reasonable sources of protein and can increase food security in rural areas. Research and development is underway to improve the grain quality and increase the productivity of these crops, both of which are negatively impacted by insect pest damage. Synthetic pesticides have proven to be the most effective control agents against all pests of minor pulses which include sap sucking insects. However, considering the drawbacks of pesticide residues in the grain, environmental pollution, and …

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Estimating Epidemiological Parameters Of A Stochastic Differential Model Of Hiv Dynamics Using Hierarchical Bayesian Statistics, Renee Dale, Bei Bei Guo Jul 2018

Estimating Epidemiological Parameters Of A Stochastic Differential Model Of Hiv Dynamics Using Hierarchical Bayesian Statistics, Renee Dale, Bei Bei Guo

Faculty Publications

Current estimates of the HIV epidemic indicate a decrease in the incidence of the disease in the undiagnosed subpopulation over the past 10 years. However, a lack of access to care has not been considered when modeling the population. Populations at high risk for contracting HIV are twice as likely to lack access to reliable medical care. In this paper, we consider three contributors to the HIV population dynamics: at-risk population exhaustion, lack of access to care, and usage of anti-retroviral therapy (ART) by diagnosed individuals. An extant problem in the mathematical study of this system is deriving parameter estimates …

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Natively Oxidized Amino Acid Residues In The Spinach Cytochrome B6 F Complex, Ryan M. Taylor, Larry Sallans, Laurie K. Frankel, Terry M. Bricker Jul 2018

Natively Oxidized Amino Acid Residues In The Spinach Cytochrome B6 F Complex, Ryan M. Taylor, Larry Sallans, Laurie K. Frankel, Terry M. Bricker

Faculty Publications

© 2018, Springer Science+Business Media B.V., part of Springer Nature. The cytochrome b6f complex of oxygenic photosynthesis produces substantial levels of reactive oxygen species (ROS). It has been observed that the ROS production rate by b6f is 10–20 fold higher than that observed for the analogous respiratory cytochrome bc1 complex. The types of ROS produced (O2•−, 1O2, and, possibly, H2O2) and the site(s) of ROS production within the b6f complex have been the subject of some debate. Proposed sources of ROS have included the heme bp, PQp•− (possible sources for O2•−), the Rieske iron–sulfur cluster (possible source of O2•− and/or …

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An Evaluation Of College Student Attitudes Toward Gay Adoption, Cassandra Chaney Phd, Le'brian Patrick Jul 2018

An Evaluation Of College Student Attitudes Toward Gay Adoption, Cassandra Chaney Phd, Le'brian Patrick

Faculty Publications

Given the increasing debate regarding same-sex marriage and same-sex adoption, few studies to date have examined college student attitudes regarding this topic. This qualitative study explores the sentiments of 31 college students from a large university in the southern region of the country towards gay adoption before and after viewing the documentary We Are Dad (2005). The study allowed students to provide their level of agreement or disagreement with the statements provided by respondents on a public blog site who debated both sides of this issue. In addition, students responded to the following two questions during two points in time: …

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Woody Plants Optimise Stomatal Behaviour Relative To Hydraulic Risk, William R.L. Anderegg, Adam Wolf, Adriana Arango-Velez, Brendan Choat, Daniel J. Chmura, Steven Jansen, Thomas Kolb, Shan Li, Frederick C. Meinzer, Pilar Pita, Víctor Resco De Dios, John S. Sperry, Brett T. Wolfe, Stephen Pacala Jul 2018

Woody Plants Optimise Stomatal Behaviour Relative To Hydraulic Risk, William R.L. Anderegg, Adam Wolf, Adriana Arango-Velez, Brendan Choat, Daniel J. Chmura, Steven Jansen, Thomas Kolb, Shan Li, Frederick C. Meinzer, Pilar Pita, Víctor Resco De Dios, John S. Sperry, Brett T. Wolfe, Stephen Pacala

Faculty Publications

Stomatal response to environmental conditions forms the backbone of all ecosystem and carbon cycle models, but is largely based on empirical relationships. Evolutionary theories of stomatal behaviour are critical for guarding against prediction errors of empirical models under future climates. Longstanding theory holds that stomata maximise fitness by acting to maintain constant marginal water use efficiency over a given time horizon, but a recent evolutionary theory proposes that stomata instead maximise carbon gain minus carbon costs/risk of hydraulic damage. Using data from 34 species that span global forest biomes, we find that the recent carbon-maximisation optimisation theory is widely supported, …

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Matrix And Area Effects On The Nutritional Condition Of Understory Birds In Amazonian Rainforest Fragments, Angélica Hernández-Palma, Philip C. Stouffer Jul 2018

Matrix And Area Effects On The Nutritional Condition Of Understory Birds In Amazonian Rainforest Fragments, Angélica Hernández-Palma, Philip C. Stouffer

Faculty Publications

Forest fragmentation, a result of deforestation, not only decreases the amount of habitat available for wildlife, but also increases the isolation of the remaining fragments and the area of edges surrounding them. Also, deforestation often leads to the creation of a dynamic regenerating matrix where cleared land is subsequently abandoned. Here we examine the effects of fragmentation and landscape change on the nutritional condition of Amazonian rainforest birds at the Biological Dynamics of Forest Fragments Project, near Manaus, Brazil. We analyzed ptilochronology-based measurements of feather growth rate in 12 species living in fragments within a dynamic landscape over 21 years. …

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What Can Mixed-Species Flock Movement Tell Us About The Value Of Amazonian Secondary Forests? Insights From Spatial Behavior, Karl Mokross, Jonathan R. Potts, Cameron L. Rutt, Philip C. Stouffer Jul 2018

What Can Mixed-Species Flock Movement Tell Us About The Value Of Amazonian Secondary Forests? Insights From Spatial Behavior, Karl Mokross, Jonathan R. Potts, Cameron L. Rutt, Philip C. Stouffer

Faculty Publications

The value of secondary forest for rain forest species remains an important question for conservation in the 21st century. Here, we describe the spatial behavior of understory mixed-species flocks in a heterogeneous landscape in central Amazonia. Understory mixed-species flocks represent a diverse, highly organized component of the rich Amazonian avifauna. We recorded movements within 26 flock home ranges in primary forest, secondary forest, interfaces between forest types, and forest fragments. We describe frequency and movement orientation in relation to forest edges, movement patterns and proportion of use between secondary and primary forest, the relation between home range sizes and vegetation …

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