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Diel Patterns Of Variable Fluorescence And Carbon Fixation Of Picocyanobacteria Prochlorococcus-Dominated Phytoplankton In The South China Sea Basin, Yuyuan Xie, Edward A. Laws, Lei Yang, Bangqin Huang Aug 2018

Diel Patterns Of Variable Fluorescence And Carbon Fixation Of Picocyanobacteria Prochlorococcus-Dominated Phytoplankton In The South China Sea Basin, Yuyuan Xie, Edward A. Laws, Lei Yang, Bangqin Huang

Faculty Publications

The various photosynthetic apparatus and light utilization strategies of phytoplankton are among the critical factors that regulate the distribution of phytoplankton and primary productivity in the ocean. Active chlorophyll fluorescence has been a powerful technique for assessing the nutritional status of phytoplankton by studying the dynamics of photosynthesis. Further studies of the energetic stoichiometry between light absorption and carbon fixation have enhanced understanding of the ways phytoplankton adapt to their niches. To explore the ecophysiology of a Prochlorococcus-dominated phytoplankton assemblage, we conducted studies of the diel patterns of variable fluorescence and carbon fixation by phytoplankton in the oligotrophic South China …

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Improved Growth Estimates For Lethrinus Harak: Measuring Increments, Adjusting Ages, And Fitting Flexible Growth Models, Stephen Midway Aug 2018

Improved Growth Estimates For Lethrinus Harak: Measuring Increments, Adjusting Ages, And Fitting Flexible Growth Models, Stephen Midway

Faculty Publications

No abstract provided.

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Fishing Pressure And Species Traits Affect Stream Fish Invasions Both Directly And Indirectly, Brandon K. Peoples, Stephen R. Midway, Brian Leung Aug 2018

Fishing Pressure And Species Traits Affect Stream Fish Invasions Both Directly And Indirectly, Brandon K. Peoples, Stephen R. Midway, Brian Leung

Faculty Publications

No abstract provided.

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The Potential For Cryptic Population Structure To Sustain A Heavily Exploited Marine Flatfish Stock, Stephen R. Midway, J. Wilson White, Frederick S. Scharf Aug 2018

The Potential For Cryptic Population Structure To Sustain A Heavily Exploited Marine Flatfish Stock, Stephen R. Midway, J. Wilson White, Frederick S. Scharf

Faculty Publications

Complex spatial structure is widely viewed as an attribute that can contribute to stability in fish populations. Depending on aspects of stock demography and productivity, the existence of complete or partial spatial refugia can enable population persistence when faced with high rates of exploitation. The Southern Flounder Paralichthys lethostigma has been harvested extensively by inshore fisheries in North Carolina for more than three decades, with estimates of fishing mortality (F) surpassing 2.0 year−1 in several years and systems. Potential hypotheses to explain population persistence under heavy exploitation include high levels of recruitment at low stock sizes (high steepness) and/or …

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Functional Analysis Of Short Linear Motifs In The Plant Cyclin-Dependent Kinase Inhibitor Siamese, Narender Kumar, Renee Dale, Daniel Kemboi, Elizabeth A. Zeringue, Naohiro Kato, John C. Larkin Aug 2018

Functional Analysis Of Short Linear Motifs In The Plant Cyclin-Dependent Kinase Inhibitor Siamese, Narender Kumar, Renee Dale, Daniel Kemboi, Elizabeth A. Zeringue, Naohiro Kato, John C. Larkin

Faculty Publications

© 2018 American Society of Plant Biologists. All rights reserved. Endoreplication, a modified cell cycle in which DNA is replicated without subsequent cell division, plays an important but poorly understood role in plant growth and in plant responses to biotic and abiotic stress. The Arabidopsis (Arabidopsis thaliana) SIAMESE (SIM) gene encodes the first identified member of the SIAMESE-RELATED (SMR) family of cyclin-dependent kinase inhibitors. SIM controls endoreplication during trichome development, and sim mutant trichomes divide several times instead of endoreplicating their DNA. The SMR family is defined by several short linear amino acid sequence motifs of largely unknown function, and …

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Designing Agricultural Economics And Agribusiness Undergraduate Programs, Jeffrey M. Gillespie, Maria Bampasidou Aug 2018

Designing Agricultural Economics And Agribusiness Undergraduate Programs, Jeffrey M. Gillespie, Maria Bampasidou

Faculty Publications

© 2018 The Author(s). This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence. Agricultural economics and agribusiness (AEAB) programs offer their graduates unique exposure to agricultural markets, policy, and production systems, which differentiates them from business programs. Despite the advantages associated with AEAB degrees, a significant challenge universities and AEAB graduates face is a general lack of recognition of what agricultural economics is and what an agricultural economist does. Using data collected from U.S. 1862 and 1890 land grant universities, we stress the importance of designing effective AEAB curricula based on enrollment trends, …

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Mitochondrial Unfolded Protein Response Gene Clpp Is Required To Maintain Ovarian Follicular Reserve During Aging, For Oocyte Competence, And Development Of Pre-Implantation Embryos, Tianren Wang, Elnur Babayev, Zongliang Jiang, Guangxin Li, Man Zhang, Ecem Esencan, Tamas Horvath, Emre Seli Aug 2018

Mitochondrial Unfolded Protein Response Gene Clpp Is Required To Maintain Ovarian Follicular Reserve During Aging, For Oocyte Competence, And Development Of Pre-Implantation Embryos, Tianren Wang, Elnur Babayev, Zongliang Jiang, Guangxin Li, Man Zhang, Ecem Esencan, Tamas Horvath, Emre Seli

Faculty Publications

© 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. Caseinolytic peptidase P mediates degradation of unfolded mitochondrial proteins and activates mitochondrial unfolded protein response (mtUPR) to maintain protein homeostasis. Clpp −/− female mice generate a lower number of mature oocytes and two-cell embryos, and no blastocysts. Clpp −/− oocytes have smaller mitochondria, with lower aspect ratio (length/width), and decreased expression of genes that promote fusion. A 4-fold increase in atretic follicles at 3 months, and reduced number of primordial follicles at 6–12 months are observed in Clpp −/− ovaries. This is associated …

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The 6xabre Synthetic Promoter Enables The Spatiotemporal Analysis Of Aba-Mediated Transcriptional Regulation, Rui Wu, Lina Duan, José L. Pruneda-Paz, Dong Ha Oh, Michael Pound, Steve Kay, José R. Dinneny Aug 2018

The 6xabre Synthetic Promoter Enables The Spatiotemporal Analysis Of Aba-Mediated Transcriptional Regulation, Rui Wu, Lina Duan, José L. Pruneda-Paz, Dong Ha Oh, Michael Pound, Steve Kay, José R. Dinneny

Faculty Publications

© 2018 American Society of Plant Biologists. All rights reserved. The water stress-associated hormone abscisic acid (ABA) acts through a well-defined signal transduction cascade to mediate downstream transcriptional events important for acclimation to stress. Although ABA signaling is known to function in specific tissues to regulate root growth, little is understood regarding the spatial pattern of ABA-mediated transcriptional regulation. Here, we describe the construction and evaluation of an ABSCISIC ACID RESPONSIVE ELEMENT (ABRE)-based synthetic promoter reporter that reveals the transcriptional response of tissues to different levels of exogenous ABA and stresses. Genome-scale yeast one-hybrid screens complemented these approaches and revealed …

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Effect Of Dietary Salt Intake On Epithelial Na+ Channels (Enacs) In The Hypothalamus Of Dahl Salt-Sensitive Rats, Natalie J. Mills, Kaustubh Sharma, Katie Huang, Ryoichi Teruyama Aug 2018

Effect Of Dietary Salt Intake On Epithelial Na+ Channels (Enacs) In The Hypothalamus Of Dahl Salt-Sensitive Rats, Natalie J. Mills, Kaustubh Sharma, Katie Huang, Ryoichi Teruyama

Faculty Publications

© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. All three epithelial Na+ channel (ENaC) subunits (α, β, and γ) and the mineralocorticoid receptor (MR), a known regulator of ENaC, are located in vasopressin (VP) synthesizing magnocellular neurons in the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei. Our previous study showed that ENaC mediates a Na+ leak current that affects the steady-state membrane potential of VP neurons. This study was conducted in Dahl salt-sensitive (Dahl-SS) rats to determine if any abnormal responses in the expression of ENaC …

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Ablation Of Ezh2 In Neural Crest Cells Leads To Aberrant Enteric Nervous System Development In Mice, Hana Kim, Ingeborg M. Langohr, Mohammad Faisal, Margaret Mcnulty, Caitlin Thorn, Joomyeong Kim Aug 2018

Ablation Of Ezh2 In Neural Crest Cells Leads To Aberrant Enteric Nervous System Development In Mice, Hana Kim, Ingeborg M. Langohr, Mohammad Faisal, Margaret Mcnulty, Caitlin Thorn, Joomyeong Kim

Faculty Publications

© 2018 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. In the current study, we examined the role of Ezh2 as an epigenetic modifier for the enteric neural crest cell development through H3K27me3. Ezh2 conditional null mice were viable up to birth, but died within the first hour of life. In addition to craniofacial defects, Ezh2 conditional null mice displayed reduced number of ganglion cells in the enteric nervous system. RT-PCR …

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Oxytocin Receptor Is Regulated By Peg3, Wesley D. Frey, Kaustubh Sharma, Terri L. Cain, Katsuhiko Nishimori, Ryoichi Teruyama, Joomyeong Kim Aug 2018

Oxytocin Receptor Is Regulated By Peg3, Wesley D. Frey, Kaustubh Sharma, Terri L. Cain, Katsuhiko Nishimori, Ryoichi Teruyama, Joomyeong Kim

Faculty Publications

© 2018 Frey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Mouse Peg3 encodes a DNA-binding protein involved in the milk letdown process. In the current study, we tested whether PEG3 controls the expression of the oxytocin receptor gene. According to the results, PEG3 directly binds to a genomic region within the 3rd exon of Oxtr, which contains a DNA-binding motif for PEG3. In nursing female mice, removal of PEG3 resulted in …

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Emodel-Bdb: A Database Of Comparative Structure Models Of Drug-Target Interactions From The Binding Database, Misagh Naderi, Rajiv Gandhi Govindaraj, Michal Brylinski Aug 2018

Emodel-Bdb: A Database Of Comparative Structure Models Of Drug-Target Interactions From The Binding Database, Misagh Naderi, Rajiv Gandhi Govindaraj, Michal Brylinski

Faculty Publications

Background: The structural information on proteins in their ligand-bound conformational state is invaluable for protein function studies and rational drug design. Compared to the number of available sequences, not only is the repertoire of the experimentally determined structures of holo-proteins limited, these structures do not always include pharmacologically relevant compounds at their binding sites. In addition, binding affinity databases provide vast quantities of information on interactions between drug-like molecules and their targets, however, often lacking structural data. On that account, there is a need for computational methods to complement existing repositories by constructing the atomic-level models of drug-protein assemblies that …

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The Dual Role Of Amazonian Rivers In The Generation And Maintenance Of Avian Diversity, Luciano N. Naka, Robb T. Brumfield Aug 2018

The Dual Role Of Amazonian Rivers In The Generation And Maintenance Of Avian Diversity, Luciano N. Naka, Robb T. Brumfield

Faculty Publications

Copyright © 2018 The Authors. The Amazon River and its major tributaries delimit the distributions of hundreds of terrestrial taxa. It remains unclear whether river-bounded distributions and taxon replacements reflect the historical role of rivers in generating species diversity as vicariant forces, or are the result of their role as secondary barriers, maintaining current levels of species diversity by inhibiting gene flow and population introgression. We use a community-wide comparative phylogeographic and phylogenetic approach to address the roles that the Rio Negro and the Rio Branco play in the avian speciation process in the Guiana Shield. Examining 74 pairs of …

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Dissolved Carbon In A Large Variety Of Lakes Across Five Limnetic Regions In China, Kaishan Song, Zhidan Wen, Yijun Xu, Hong Yang, Lili Lyu, Ying Zhao, Chong Fang, Yingxin Shang, Jia Du Aug 2018

Dissolved Carbon In A Large Variety Of Lakes Across Five Limnetic Regions In China, Kaishan Song, Zhidan Wen, Yijun Xu, Hong Yang, Lili Lyu, Ying Zhao, Chong Fang, Yingxin Shang, Jia Du

Faculty Publications

Dissolved carbon in lakes play a vital role in the global carbon cycling. The concentration and dynamics of lake dissolved carbon can be influenced by both the surrounding landscape and a combination of physical, chemical and biological processes within the lakes themselves. From 2009 to 2016, we conducted a large-scale assessment of dissolved organic carbon (DOC) and dissolved inorganic carbon (DIC) in 249 lakes across a diverse range of climatic, geopedologic, topographical and hydrological conditions in five Chinese limnetic regions: the East Limnetic Region (ELR), the Northeast Limnetic Region (NLR), the Inner Mongolia-Xinjiang Limnetic Region (MXR), the Yungui Limnetic Region …

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Evaluation Of Commercial-Scale Approaches For Cryopreservation Of White Crappie, Pomoxis Annularis, Sperm, Charlie M. Culpepper, Amy M. Guitreau, Shay Allred, Terrence R. Tiersch, Peter J. Allen Aug 2018

Evaluation Of Commercial-Scale Approaches For Cryopreservation Of White Crappie, Pomoxis Annularis, Sperm, Charlie M. Culpepper, Amy M. Guitreau, Shay Allred, Terrence R. Tiersch, Peter J. Allen

Faculty Publications

Crappie, Pomoxis spp., are popular game fish throughout North America and are produced by public and private hatcheries. However, production is limited by a lack of information on tank culture and induced spawning methods. Development of techniques for storage of sperm and in vitro fertilization would increase flexibility in spawning. Therefore, techniques for sperm cryopreservation were examined in white crappie, Pomoxis annularis. Sperm from adult wild white crappie were used to evaluate sperm extender, cryoprotectant agent and concentration, and cooling technique based on post-thaw sperm motility. Percent egg fertilization was also compared between sperm stored in the two best cryopreservation …

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Addressing Reproducibility In Cryopreservation, And Considerations Necessary For Commercialization And Community Development In Support Of Genetic Resources Of Aquatic Species, Leticia Torres, Terrence R. Tiersch Aug 2018

Addressing Reproducibility In Cryopreservation, And Considerations Necessary For Commercialization And Community Development In Support Of Genetic Resources Of Aquatic Species, Leticia Torres, Terrence R. Tiersch

Faculty Publications

For the past six decades a repeated cycle of developing new cryopreservation protocols or simply reinventing them to counteract a lack of reproducibility has led to hundreds of published studies that have offered little to the establishment of a genetic resources community for aquatic species. This has hampered repository development and inhibited industrial application. Most protocols were developed without standardized approaches, leading to irreproducible studies and questionable or meaningless comparisons. Thus cryopreservation of germplasm in aquatic species would greatly benefit from strategies to facilitate reproducibility. Our objectives were to: (1) identify major sources of irreproducibility across research, small-scale, repository, and …

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Biochar Produced From Mineral Salt-Impregnated Chicken Manure: Fertility Properties And Potential For Carbon Sequestration, Ran Xiao, Jim J. Wang, Lewis A. Gaston, Baoyue Zhou, Jong Hwan Park, Ronghua Li, Syam K. Dodla, Zengqiang Zhang Aug 2018

Biochar Produced From Mineral Salt-Impregnated Chicken Manure: Fertility Properties And Potential For Carbon Sequestration, Ran Xiao, Jim J. Wang, Lewis A. Gaston, Baoyue Zhou, Jong Hwan Park, Ronghua Li, Syam K. Dodla, Zengqiang Zhang

Faculty Publications

In this study, nutrient properties and carbon sequestration potential of biochars derived from chicken manure (CM) impregnated with mineral salts (calcium chloride, magnesium chloride, ferric chloride) were evaluated. Pretreatment with mineral salts reduced phosphorus (P) availability via the formation of insoluble metal phosphate minerals. Less carbon was lost during the pyrolysis of pretreated CM, and the produced biochars (BCCa, BCMg, and BCFe) were more stable (i.e., reduced C loss during chemical oxidation and less CO2 release during incubation) than pristine biochars. Spectroscopic evidence indicated that enhanced biochar stability via metal salt pretreatment before pyrolysis was related to increased aromatization and …

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Influence Of Physicians’ Beliefs On Propensity To Include Religion/Spirituality In Patient Interactions, Aaron B. Franzen Aug 2018

Influence Of Physicians’ Beliefs On Propensity To Include Religion/Spirituality In Patient Interactions, Aaron B. Franzen

Faculty Publications

This study examines physicians’ beliefs, their perceptions of whether religion impacts health outcomes, and their propensity to discuss religion/spirituality with patients. It is not uncommon for patients to want religious/spiritual conversations, but the occurrence is infrequent. This study adds to knowledge regarding which physicians include these topics. Using a nationally representative sample of physicians and a mediated bi-factor structural equation model, the author finds that “religious and spiritual” physicians connect religion and patient health more than other religious/spiritual orientations. As a result, “religious and spiritual” physicians include religion/spirituality most often (indirect path). After this variation is accounted for, “spiritual but …

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Electrochemical Glucose Sensors Enhanced By Methyl Viologen And Vertically Aligned Carbon Nanotube Channels, Benjamin J. Brownlee, Meisam Bahari, John N. Harb, Jonathan C. Claussen, Brian D. Iverson Aug 2018

Electrochemical Glucose Sensors Enhanced By Methyl Viologen And Vertically Aligned Carbon Nanotube Channels, Benjamin J. Brownlee, Meisam Bahari, John N. Harb, Jonathan C. Claussen, Brian D. Iverson

Faculty Publications

Freestanding, vertically aligned carbon nanotubes (VACNTs) were patterned into 16 μm diameter microchannel arrays for flow-through electrochemical glucose sensing. Non-enzymatic sensing of glucose was achieved by the chemical reaction of glucose with methyl viologen (MV) at an elevated temperature and pH (0.1 M NaOH), followed by the electrochemical reaction of reduced-MV with the VACNT surface. The MV sensor required no functionalization (including no metal) and was able to produce on average 3.4 electrons per glucose molecule. The current density of the MV sensor was linear with both flow rate and glucose concentration. Challenges with interference chemicals were mitigated by operating …

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The Emperor’S New Clothes: The Variety Of Stakeholders In Climate Change Regulation Assuming The Mantle Of Federal And International Authority, Linda A. Malone Aug 2018

The Emperor’S New Clothes: The Variety Of Stakeholders In Climate Change Regulation Assuming The Mantle Of Federal And International Authority, Linda A. Malone

Faculty Publications

In June 2017, President Donald Trump announced the United States would be withdrawing from the Paris Climate Accord. President Trump believes the United States should be more focused on its economic wellbeing than on environmental concerns. Since being elected, President Trump has, with the help of the Environmental Protection Agency, been rolling back, or attempting to roll back, major climate change regulations. However, this Article points out that due to factors such as international law, the United States Constitution, and the Administrative Procedure Act, one cannotjust simply withdraw from an international agreement, such as the Paris Accord, or take back …

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'Neurophobia,' A Reply To Patterson, Peter A. Alces Aug 2018

'Neurophobia,' A Reply To Patterson, Peter A. Alces

Faculty Publications

No abstract provided.

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Electrochemical Glucose Sensors Enhanced By Methyl Viologen And Vertically Aligned Carbon Nanotube Channels, Benjamin J. Brownlee, Meisam Bahari, John H. Harb, Jonathan C. Claussen, Brian D. Iverson Aug 2018

Electrochemical Glucose Sensors Enhanced By Methyl Viologen And Vertically Aligned Carbon Nanotube Channels, Benjamin J. Brownlee, Meisam Bahari, John H. Harb, Jonathan C. Claussen, Brian D. Iverson

Faculty Publications

Free-standing, vertically aligned carbon nanotubes (VACNTs) were patterned into 16 μm diameter microchannel arrays for flow-through electrochemical glucose sensing. Non-enzymatic sensing of glucose was achieved by the chemical reaction of glucose with methyl viologen (MV) at an elevated temperature and pH (0.1 M NaOH), followed by the electrochemical reaction of reduced-MV with the VACNT surface. The MV sensor required no functionalization (including no metal) and was able to produce on average 3.4 electrons per glucose molecule. The current density of the MV sensor was linear with both flow rate and glucose concentration. Challenges with interference chemicals were mitigated by operating …

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Skin Glands Of An Aquatic Salamander Vary In Size And Distribution And Release Antimicrobial Secretions Effective Against Chytrid Fungal Pathogens, Kenzie E. Pereira, Brian I. Crother, David M. Sever, Clifford L. Fontenot, John A. Pojman, Damien B. Wilburn, Sarah K. Woodley Jul 2018

Skin Glands Of An Aquatic Salamander Vary In Size And Distribution And Release Antimicrobial Secretions Effective Against Chytrid Fungal Pathogens, Kenzie E. Pereira, Brian I. Crother, David M. Sever, Clifford L. Fontenot, John A. Pojman, Damien B. Wilburn, Sarah K. Woodley

Faculty Publications

© 2018. Published by The Company of Biologists Ltd. Amphibian skin is unique among vertebrate classes, containing a large number of multicellular exocrine glands that vary among species and have diverse functions. The secretions of skin glands contain a rich array of bioactive compounds including antimicrobial peptides (AMPs). Such compounds are important for amphibian innate immune responses and may protect some species from chytridiomycosis, a lethal skin disease caused by the fungal pathogens Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal). While the bioactivity of skin secretions against Bd has been assessed for many amphibian taxa, similar studies are lacking for …

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Nickel Exposure Reduces Enterobactin Production In Escherichia Coli, Clorissa L. Washington-Hughes, Geoffrey T. Ford, Alsten D. Jones, Kimberly Mcrae, Franklin Wayne Outten Jul 2018

Nickel Exposure Reduces Enterobactin Production In Escherichia Coli, Clorissa L. Washington-Hughes, Geoffrey T. Ford, Alsten D. Jones, Kimberly Mcrae, Franklin Wayne Outten

Faculty Publications

Escherichia coli is a well- studied bacterium that can be found in many niches, such as industrial wastewater, where the concentration of nickel can rise to low- millimolar levels. Recent studies show that nickel exposure can repress pyochelin or induce pyo-verdine siderophore production in Pseudomonas aueroginosa. Understanding the mo-lecular cross- talk between siderophore production, metal homeostasis, and metal toxicity in microorganisms is critical for designing bioremediation strategies for metal- contaminated sites. Here, we show that high- nickel exposure prolongs lag phase duration as a result of low- intracellular iron levels in E. coli. Although E. coli cells respond to low- …

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Nickel Exposure Reduces Enterobactin Production In Escherichia Coli, Clorissa L. Washington – Hughes, Geoffrey T. Ford, Alsten D. Jones, Kimberly Mcrae, Franklin W. Outten Jul 2018

Nickel Exposure Reduces Enterobactin Production In Escherichia Coli, Clorissa L. Washington – Hughes, Geoffrey T. Ford, Alsten D. Jones, Kimberly Mcrae, Franklin W. Outten

Faculty Publications

Escherichia coli is a well- studied bacterium that can be found in many niches, such as industrial wastewater, where the concentration of nickel can rise to low- millimolar levels. Recent studies show that nickel exposure can repress pyochelin or induce pyo-verdine siderophore production in Pseudomonas aueroginosa. Understanding the mo-lecular cross- talk between siderophore production, metal homeostasis, and metal toxicity in microorganisms is critical for designing bioremediation strategies for metal- contaminated sites. Here, we show that high- nickel exposure prolongs lag phase duration as a result of low- intracellular iron levels in E. coli. Although E. coli cells respond to low- …

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Hiv-1 Integrase-Targeted Short Peptides Derived From A Viral Protein R Sequence, Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke Jr. Jul 2018

Hiv-1 Integrase-Targeted Short Peptides Derived From A Viral Protein R Sequence, Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke Jr.

Faculty Publications

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions. However, the emergence of IN mutants having reduced sensitivity to these inhibitors underlies efforts to derive agents that antagonize IN function by alternate mechanisms. Integrase along with the 96-residue multifunctional accessory protein, viral protein R (Vpr), are both components of the HIV-1 pre-integration complex (PIC). Coordinated interactions within the PIC are important for viral replication. Herein, we report a 7-mer peptide based on the shortened Vpr …

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Responses Of Non-Native Earthworms To Experimental Eradication Of Garlic Mustard And Implications For Native Vegetation, Kristina A. Stinson, Serita D. Frey, M. R. Jackson, E. Coates-Connor, Mark A. Anthony, K. Martinez Jul 2018

Responses Of Non-Native Earthworms To Experimental Eradication Of Garlic Mustard And Implications For Native Vegetation, Kristina A. Stinson, Serita D. Frey, M. R. Jackson, E. Coates-Connor, Mark A. Anthony, K. Martinez

Faculty Publications

Recent studies in invasion biology suggest that positive feedback among two or more introduced organisms facilitate establishment within a new range and drive changes in native plant communities. Here, we experimentally tested for relationships between native plants and two non-native organisms invading forest habitats in North America: garlic mustard (Alliaria petiolata, Brassicaceae) and earthworms. In two forested sites, we compared understory vegetation and earthworm biomass in plots where garlic mustard was removed for three years, plots without garlic mustard invasion, and plots invaded by garlic mustard that was not removed. Earthworm biomass was highest in the plots with garlic mustard, …

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Unraveling Substituent Effects On The Glass Transition Temperatures Of Biorenewable Polyesters, Xiaopeng Yu, Junteng Jia, Shu Xu, Ka Un Lao, Maria J. Sanford, Ramesh K. Ramakrishnan, Sergei I. Nazarenko, Thomas R. Hoye, Geoffrey W. Coates, Robert A. Distasio Jr. Jul 2018

Unraveling Substituent Effects On The Glass Transition Temperatures Of Biorenewable Polyesters, Xiaopeng Yu, Junteng Jia, Shu Xu, Ka Un Lao, Maria J. Sanford, Ramesh K. Ramakrishnan, Sergei I. Nazarenko, Thomas R. Hoye, Geoffrey W. Coates, Robert A. Distasio Jr.

Faculty Publications

Converting biomass-based feedstocks into polymers not only reduces our reliance on fossil fuels, but also furnishes multiple opportunities to design biorenewable polymers with targeted properties and functionalities. Here we report a series of high glass transition temperature (Tg up to 184 °C) polyesters derived from sugar-based furan derivatives as well as a joint experimental and theoretical study of substituent effects on their thermal properties. Surprisingly, we find that polymers with moderate steric hindrance exhibit the highest Tg values. Through a detailed Ramachandran-type analysis of the rotational flexibility of the polymer backbone, we find that additional steric hindrance does …

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Human Activities Accelerated The Degradation Of Saline Seepweed Red Beaches By Amplifying Top‐Down And Bottom‐Up Forces, Weizhi Lu, Jingfeng Xiao, Wei Lei, Jinqiu Du, Zhengjie Li, Pifu Cong, Wenhao Hou, Jialin Zhang, Luzhen Chen, Yihui Zhang, Guoxiang Liao Jul 2018

Human Activities Accelerated The Degradation Of Saline Seepweed Red Beaches By Amplifying Top‐Down And Bottom‐Up Forces, Weizhi Lu, Jingfeng Xiao, Wei Lei, Jinqiu Du, Zhengjie Li, Pifu Cong, Wenhao Hou, Jialin Zhang, Luzhen Chen, Yihui Zhang, Guoxiang Liao

Faculty Publications

Salt marshes dominated by saline seepweed (Suaeda heteroptera) provide important ecosystem services such as sequestering carbon (blue carbon), maintaining healthy fisheries, and protecting shorelines. These salt marshes also constitute stunning red beach landscapes, and the resulting tourism significantly contributes to the local economy. However, land use change and degradation have led to a substantial loss of the red beach area. It remains unclear how human activities influence the top‐down and bottom‐up forces that regulate the distribution and succession of these salt marshes and lead to the degradation of the red beaches. We examined how bottom‐up forces influenced the germination, emergence, …

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The Csbg - Lsu Gateway: Web Based Hosted Gateway For Computational System Biology Application Tools From Louisiana State University, Eroma Abeysinghe, Michal Brylinski, Marcus Christie, Suresh Marru, Marlon Pierce Jul 2018

The Csbg - Lsu Gateway: Web Based Hosted Gateway For Computational System Biology Application Tools From Louisiana State University, Eroma Abeysinghe, Michal Brylinski, Marcus Christie, Suresh Marru, Marlon Pierce

Faculty Publications

© 2018 Copyright held by the owner/author(s). Science gateways are identified as an effective way to publish and distribute software for research communities without the burden of learning HPC (High Performance Computer) systems. In the past, researchers were expected to have in-depth knowledge about using HPC systems for computations along with their respective science field in order to do effective research. Science gateways eliminate the need to learn HPC systems and allows the research communities to focus more on their science and let the gateway handle communicating with HPCs. In this poster we are presenting the science gateway project of …

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